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Michael Cashel

Research Profile

Chemicals & Drugs

Living Beings

Escherichia coli

Genes & Molecular Sequences

Concepts & Ideas

Molecular Sequence Data

Physiology

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Publications

TOP 3
Adrianne N Edwards; Joshua A Fields; Dimitris Georgellis; Jeffrey Mercante; Laura M Patterson-Fortin; Katarzyna Potrykus; Paul Babitzke; Martha I Camacho; Michael Cashel; Stuart A Thompson; Christopher A Vakulskas; Daniel Vinella; Tony Romeo
Circuitry linking the Csr and stringent response global regulatory systems.
Katarzyna Potrykus; Helen Murphy; Nadège Philippe; Michael Cashel
ppGpp is the major source of growth rate control in E. coli.
Tamara D James; Michael Cashel; Deborah M Hinton
A mutation within the β subunit of Escherichia coli RNA polymerase impairs transcription from bacteriophage T4 middle promoters.

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All Publications

2011: Adrianne N Edwards; Joshua A Fields; Dimitris Georgellis; Jeffrey Mercante; Laura M Patterson-Fortin; Katarzyna Potrykus; Paul Babitzke; Martha I Camacho; Michael Cashel; Stuart A Thompson; Christopher A Vakulskas; Daniel Vinella; Tony Romeo
Circuitry linking the Csr and stringent response global regulatory systems.
Molecular microbiology 2011;80(6):1561-80.
2011: Katarzyna Potrykus; Helen Murphy; Nadège Philippe; Michael Cashel
ppGpp is the major source of growth rate control in E. coli.
Environmental microbiology 2011;13(3):563-75.
2010: Tamara D James; Michael Cashel; Deborah M Hinton
A mutation within the β subunit of Escherichia coli RNA polymerase impairs transcription from bacteriophage T4 middle promoters.
Journal of bacteriology 2010;192(21):5580-7.
2010: Katarzyna Potrykus; Helen Murphy; Xiongfong Chen; Jonathan A Epstein; Michael Cashel
Imprecise transcription termination within Escherichia coli greA leader gives rise to an array of short transcripts, GraL.
Nucleic acids research 2010;38(5):1636-51.
2008: Rajendran Harinarayanan; Helen Murphy; Michael Cashel
Synthetic growth phenotypes of Escherichia coli lacking ppGpp and transketolase A (tktA) are due to ppGpp-mediated transcriptional regulation of tktB.
Molecular microbiology 2008;69(4):882-94.
2008: Hyun-Woo Rhee; Chang-Ro Lee; Seung-Hyon Cho; Mi-Ryung Song; Michael Cashel; Hyon E Choy; Yeong-Jae Seok; Jong-In Hong
Selective fluorescent chemosensor for the bacterial alarmone (p)ppGpp.
Journal of the American Chemical Society 2008;130(3):784-5.
2008: Katarzyna Potrykus; Michael Cashel
(p)ppGpp: still magical?
Annual review of microbiology 2008;62():35-51.
2006: Katarzyna Potrykus; Daniel Vinella; Helen Murphy; Agnieszka Szalewska-Palasz; Richard D'Ari; Michael Cashel
Antagonistic regulation of Escherichia coli ribosomal RNA rrnB P1 promoter activity by GreA and DksA.
The Journal of biological chemistry 2006;281(22):15238-48.
2005: Daniel Vinella; Christian Albrecht; Michael Cashel; Richard D'Ari
Iron limitation induces SpoT-dependent accumulation of ppGpp in Escherichia coli.
Molecular microbiology 2005;56(4):958-70.
2004: Tanis Hogg; Undine Mechold; Horst Malke; Michael Cashel; Rolf Hilgenfeld
Conformational antagonism between opposing active sites in a bifunctional RelA/SpoT homolog modulates (p)ppGpp metabolism during the stringent response [corrected].
Cell 2004;117(1):57-68.
2003: Michael Cashel; Lilian M Hsu; V James Hernandez
Changes in conserved region 3 of Escherichia coli sigma 70 reduce abortive transcription and enhance promoter escape.
The Journal of biological chemistry 2003;278(8):5539-47.
2003: Helen Murphy; Michael Cashel
Isolation of RNA polymerase suppressors of a (p)ppGpp deficiency.
Methods in enzymology 2003;371():596-601.
2002: Larissa Brown; Daniel Gentry; Thomas Elliott; Michael Cashel
DksA affects ppGpp induction of RpoS at a translational level.
Journal of bacteriology 2002;184(16):4455-65.
2002: Undine Mechold; Helen Murphy; Larissa Brown; Michael Cashel
Intramolecular regulation of the opposing (p)ppGpp catalytic activities of Rel(Seq), the Rel/Spo enzyme from Streptococcus equisimilis.
Journal of bacteriology 2002;184(11):2878-88.
2000: Daniel Vinella; Michael Cashel; Richard D'Ari
Selected amplification of the cell division genes ftsQ-ftsA-ftsZ in Escherichia coli.
Genetics 2000;156(4):1483-92.
1998: Borys Wróbel; Helen Murphy; Michael Cashel; Grzegorz Wegrzyn
Guanosine tetraphosphate (ppGpp)-mediated inhibition of the activity of the bacteriophage lambda pR promoter in Escherichia coli.
Molecular & general genetics : MGG 1998;257(4):490-5.
1997: A Kuroda; Helen Murphy; Michael Cashel; Arthur Kornberg
Guanosine tetra- and pentaphosphate promote accumulation of inorganic polyphosphate in Escherichia coli.
The Journal of biological chemistry 1997;272(34):21240-3.
1996: V J Hernandez; L M Hsu; Michael Cashel
Conserved region 3 of Escherichia coli final sigma70 is implicated in the process of abortive transcription.
The Journal of biological chemistry 1996;271(31):18775-9.
1996: Daniel Vinella; B Gagny; Danièle Joseleau-Petit; Richard D'Ari; Michael Cashel
Mecillinam resistance in Escherichia coli is conferred by loss of a second activity of the AroK protein.
Journal of bacteriology 1996;178(13):3818-28.
1996: D R Gentry; Michael Cashel
Mutational analysis of the Escherichia coli spoT gene identifies distinct but overlapping regions involved in ppGpp synthesis and degradation.
Molecular microbiology 1996;19(6):1373-84.
1996: Undine Mechold; Michael Cashel; Kerstin Steiner; D Gentry; Horst Malke
Functional analysis of a relA/spoT gene homolog from Streptococcus equisimilis.
Journal of bacteriology 1996;178(5):1401-11.
1995: V J Hernandez; Michael Cashel
Changes in conserved region 3 of Escherichia coli sigma 70 mediate ppGpp-dependent functions in vivo.
Journal of molecular biology 1995;252(5):536-49.
1995: D R Gentry; Michael Cashel
Cellular localization of the Escherichia coli SpoT protein.
Journal of bacteriology 1995;177(13):3890-3.
1993: D R Gentry; V J Hernandez; L H Nguyen; D B Jensen; Michael Cashel
Synthesis of the stationary-phase sigma factor sigma s is positively regulated by ppGpp.
Journal of bacteriology 1993;175(24):7982-9.
1993: D Gentry; C Bengra; K Ikehara; Michael Cashel
Guanylate kinase of Escherichia coli K-12.
The Journal of biological chemistry 1993;268(19):14316-21.
1992: P G Jones; Michael Cashel; Gad Glaser; F C Neidhardt
Function of a relaxed-like state following temperature downshifts in Escherichia coli.
Journal of bacteriology 1992;174(12):3903-14.
1992: M Kalman; Helen Murphy; Michael Cashel
The nucleotide sequence of recG, the distal spo operon gene in Escherichia coli K-12.
Gene 1992;110(1):95-9.
1991: M Kalman; Helen Murphy; Michael Cashel
rhlB, a new Escherichia coli K-12 gene with an RNA helicase-like protein sequence motif, one of at least five such possible genes in a prokaryote.
The New biologist 1991;3(9):886-95.
1991: D Gentry; Hua Xiao; R Burgess; Michael Cashel
The omega subunit of Escherichia coli K-12 RNA polymerase is not required for stringent RNA control in vivo.
Journal of bacteriology 1991;173(12):3901-3.
1991: Hua Xiao; M Kalman; K Ikehara; S Zemel; Gad Glaser; Michael Cashel
Residual guanosine 3',5'-bispyrophosphate synthetic activity of relA null mutants can be eliminated by spoT null mutations.
The Journal of biological chemistry 1991;266(9):5980-90.
1991: M Kalman; D R Gentry; Michael Cashel
Characterization of the Escherichia coli K12 gltS glutamate permease gene.
Molecular & general genetics : MGG 1991;225(3):379-86.
1991: G Schreiber; S Metzger; E Aizenman; S Roza; Michael Cashel; Gad Glaser
Overexpression of the relA gene in Escherichia coli.
The Journal of biological chemistry 1991;266(6):3760-7.
1990: M Kalman; E T Kalman; Michael Cashel
Polymerase chain reaction (PCR) amplification with a single specific primer.
Biochemical and biophysical research communications 1990;167(2):504-6.
1989: S Metzger; G Schreiber; E Aizenman; Michael Cashel; Gad Glaser
Characterization of the relA1 mutation and a comparison of relA1 with new relA null alleles in Escherichia coli.
The Journal of biological chemistry 1989;264(35):21146-52.
1989: E Sarubbi; Kenneth E Rudd; Hua Xiao; K Ikehara; M Kalman; Michael Cashel
Characterization of the spoT gene of Escherichia coli.
The Journal of biological chemistry 1989;264(25):15074-82.
1989: S Metzger; E Sarubbi; Gad Glaser; Michael Cashel
Protein sequences encoded by the relA and the spoT genes of Escherichia coli are interrelated.
The Journal of biological chemistry 1989;264(16):9122-5.
1988: S Metzger; I B Dror; E Aizenman; G Schreiber; M Toone; J D Friesen; Michael Cashel; Gad Glaser
The nucleotide sequence and characterization of the relA gene of Escherichia coli.
The Journal of biological chemistry 1988;263(30):15699-704.
1988: E Sarubbi; Kenneth E Rudd; Michael Cashel
Basal ppGpp level adjustment shown by new spoT mutants affect steady state growth rates and rrnA ribosomal promoter regulation in Escherichia coli.
Molecular & general genetics : MGG 1988;213(2-3):214-22.
1985: Kenneth E Rudd; Barry R Bochner; Michael Cashel; J R Roth
Mutations in the spoT gene of Salmonella typhimurium: effects on his operon expression.
Journal of bacteriology 1985;163(2):534-42.
1983: P Sarmientos; Michael Cashel
Carbon starvation and growth rate-dependent regulation of the Escherichia coli ribosomal RNA promoters: differential control of dual promoters.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(22):7010-3.
1983: P Sarmientos; J E Sylvester; S Contente; Michael Cashel
Differential stringent control of the tandem E. coli ribosomal RNA promoters from the rrnA operon expressed in vivo in multicopy plasmids.
Cell 1983;32(4):1337-46.
1983: Gad Glaser; P Sarmientos; Michael Cashel
Functional interrelationship between two tandem E. coli ribosomal RNA promoters.
Nature 1983;302(5903):74-6.
1980: J E Sylvester; Michael Cashel
Stable RNA-DNA-RNA polymerase complexes can accompany formation of a single phosphodiester bond.
Biochemistry 1980;19(6):1069-74.