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Mark Cookson

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Azad Kumar; Ravindran Kumaran; Mina Ryten; Andrew B Singleton; Colin Smith; Daniah Trabzuni; Bryan Joseph Traynor; Robert Walker; Alexandra Beilina; Allissa Dillman; J Raphael Gibbs; John Hardy; Mark Cookson
Age-associated changes in gene expression in human brain and isolated neurons.
Mark Cookson
Parkinsonism due to mutations in PINK1, parkin, and DJ-1 and oxidative stress and mitochondrial pathways.
Alexandre Kuhn; Azad Kumar; Alexandra Beilina; Mark Cookson; Allissa Dillman; Andrew B Singleton
Cell population-specific expression analysis of human cerebellum.

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All Publications

2013: Azad Kumar; Ravindran Kumaran; Mina Ryten; Andrew B Singleton; Colin Smith; Daniah Trabzuni; Bryan Joseph Traynor; Robert Walker; Alexandra Beilina; Allissa Dillman; J Raphael Gibbs; John Hardy; Mark Cookson
Age-associated changes in gene expression in human brain and isolated neurons.
Neurobiology of aging 2013;34(4):1199-209.
2012: Mark Cookson
Parkinsonism due to mutations in PINK1, parkin, and DJ-1 and oxidative stress and mitochondrial pathways.
Cold Spring Harbor perspectives in medicine 2012;2(9):a009415.
2012: Alexandre Kuhn; Azad Kumar; Alexandra Beilina; Mark Cookson; Allissa Dillman; Andrew B Singleton
Cell population-specific expression analysis of human cerebellum.
BMC genomics 2012;13():610.
2012: Laura Civiero; Mark Cookson; Marc De Maeyer; Fangye Gao; Elisa Greggio; Evy Lobbestael; Ivan Micetic; Lauran Reyniers; Veerle Baekelandt; Alexandra Beilina; Elisa Belluzzi; Luigi Bubacco; Renée Vancraenenbroeck; Jean-Marc Taymans
Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers.
PloS one 2012;7(8):e43472.
2011: Wei Wang; Brian N Webb; Jeffrey N Agar; Francisco J Asturias; Jared R Auclair; Johnathan Chittuluru; Mark Cookson; Derrick Johnson; Shulin Ju; Alice Kaganovich; Chulhee Kang; Anuradha Landeru; Jingling Liao; Linh T T Nguyen; Iva Perovic; Gregory A Petsko; Thomas C Pochapsky; Dagmar Ringe; Alana K Simorellis; Quyen Q Hoang
A soluble α-synuclein construct forms a dynamic tetramer.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(43):17797-802.
2011: David N Hauser; Mark Cookson
Astrocytes in Parkinson's disease and DJ-1.
Journal of neurochemistry 2011;117(3):357-8.
2011: Dena G Hernandez; Michael A Nalls; J Raphael Gibbs; Sampath Arepalli; Marcel van der Brug; Sean Chong; Matthew Moore; Dan L Longo; Mark Cookson; Bryan Joseph Traynor; Andrew Singleton
Distinct DNA methylation changes highly correlated with chronological age in the human brain.
Human molecular genetics 2011;20(6):1164-72.
2011: Shiao-Lin Lai; Yevgeniya Abramzon; Jennifer C Schymick; Dietrich A Stephan; Travis Dunckley; Allissa Dillman; Mark Cookson; Andrea Calvo; Stefania Battistini; Fabio Giannini; Claudia Caponnetto; Giovanni Luigi Mancardi; Rossella Spataro; Maria Rosaria Monsurro; Gioacchino Tedeschi; Kalliopi Marinou; Mario Sabatelli; Amelia Conte; Jessica Mandrioli; Patrizia Sola; Fabrizio Salvi; Ilaria Bartolomei; Federica Lombardo; Gabriele Mora; Gabriella Restagno; Adriano Chio; Bryan Joseph Traynor
FUS mutations in sporadic amyotrophic lateral sclerosis.
Neurobiology of aging 2011;32(3):550.e1-4.
2011: Jean-Marc Taymans; Renée Vancraenenbroeck; Veerle Baekelandt; Alexandra Beilina; Marc De Maeyer; Evy Lobbestael; Petri Ollikainen; Mark Cookson
LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding.
PloS one 2011;6(8):e23207.
2011: Michael J Devine; Allissa Dillman; John Hardy; Daniel Healey; Susannah Horan; Alice Kaganovich; Rina Bandopadhyay; Diane Chan; Mark Cookson; Adamantios Mamais; Claudia Manzoni; Jose-Felix Marti-Masso; Philip McGoldrick; Mina Ryten; Anthony H Schapira; Jan-Willem Taanman; Daniah Trabzuni; Marcel van der Brug; Benjamin Wolozin; Julia Zerle; Daniel Healy; Patrick A Lewis
Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue.
PloS one 2011;6(7):e22489.
2011: Veronique Daniëls; Renée Vancraenenbroeck; Bernard M H Law; Elisa Greggio; Evy Lobbestael; Fangye Gao; Marc De Maeyer; Mark Cookson; Kirsten Harvey; Veerle Baekelandt; Jean-Marc Taymans
Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant.
Journal of neurochemistry 2011;116(2):304-15.
2011: Kelly Jean Thomas; Melissa K McCoy; Jeff Blackinton; Alexandra Beilina; Marcel van der Brug; Anna Sandebring; David Miller; Dragan Maric; Angel Cedazo-Minguez; Mark Cookson
DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.
Human molecular genetics 2011;20(1):40-50.
2010: Minerva M Carrasquillo; Alexandra M Nicholson; NiCole Finch; J Raphael Gibbs; Matt Baker; Nicola J Rutherford; Talisha A Hunter; Mariely DeJesus-Hernandez; Gina D Bisceglio; Ian R Mackenzie; Andrew Singleton; Mark Cookson; Julia E Crook; Allissa Dillman; Dena Hernandez; Ronald C. Petersen; Neill R Graff-Radford; Steven G Younkin; Rosa Rademakers
Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma.
American journal of human genetics 2010;87(6):890-7.
2010: Mark Cookson
The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease.
Nature reviews. Neuroscience 2010;11(12):791-7.
2010: Tohru Matsuki; Russell T Matthews; Jonathan A Cooper; Marcel P van der Brug; Mark Cookson; John Hardy; Eric C Olson; Brian W Howell
Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment.
Cell 2010;143(5):826-36.
2010: Iakov N Rudenko; Mark Cookson
14-3-3 proteins are promising LRRK2 interactors.
The Biochemical journal 2010;430(3):e5-6.
2010: Bryan Joseph Traynor; Michael Nalls; Shiao-Lin Lai; Raphael J Gibbs; Jennifer C Schymick; Sampath Arepalli; Dena Hernandez; Marcel P van der Brug; Janel Johnson; Allissa Dillman; Mark Cookson; Cristina Moglia; Andrea Calvo; Gabriella Restagno; Gabriele Mora; Adriano Chio
Kinesin-associated protein 3 (KIFAP3) has no effect on survival in a population-based cohort of ALS patients.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(27):12335-8.
2010: Marcel van der Brug; Michael A Nalls; Mark Cookson
Deep sequencing of coding and non-coding RNA in the CNS.
Brain research 2010;1338():146-54.
2010: J Raphael Gibbs; Marcel P van der Brug; Dena G Hernandez; Bryan Joseph Traynor; Michael A Nalls; Shiao-Lin Lai; Sampath Arepalli; Allissa Dillman; Ian P Rafferty; Juan C Troncoso; Robert Johnson; H Ronald Zielke; Luigi Ferrucci; Dan L Longo; Mark Cookson; Andrew Singleton
Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain.
PLoS genetics 2010;6(5):e1000952.
2010: Mark Cookson; Oliver Bandmann
Parkinson's disease: insights from pathways.
Human molecular genetics 2010;19(R1):R21-7.
2010: Jean-Marc Taymans; Mark Cookson
Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau.
BioEssays : news and reviews in molecular, cellular and developmental biology 2010;32(3):227-35.
2010: Cindy H Hsu; Diane Chan; Elisa Greggio; Shamol Saha; Maria D Guillily; Andrew Ferree; Kesav Raghavan; Grace C Shen; Lilach Segal; Hoon Ryu; Mark Cookson; Benjamin Wolozin
MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2.
Journal of neurochemistry 2010;112(6):1593-604.
2010: Mark Cookson
Unravelling the role of defective genes.
Progress in brain research 2010;183():43-57.
2010: Mohammad Faghihi; Ming Zhang; Jia Huang; Farzaneh Modarresi; Marcel P Van der Brug; Michael A Nalls; Mark Cookson; Georges St-Laurent; Claes Wahlestedt
Evidence for natural antisense transcript-mediated inhibition of microRNA function.
Genome biology 2010;11(5):R56.
2010: Marco Bisaglia; Elisa Greggio; Dragan Maric; David W Miller; Mark Cookson; Luigi Bubacco
Alpha-synuclein overexpression increases dopamine toxicity in BE2-M17 cells.
BMC neuroscience 2010;11():41.
2010: Mark Cookson
DJ-1, PINK1, and their effects on mitochondrial pathways.
Movement disorders : official journal of the Movement Disorder Society 2010;25 Suppl 1():S44-8.
2010: Derek P Narendra; Seok Min Jin; Atsushi Tanaka; Der Fen Suen; Clement A Gautier; Jie Shen; Mark Cookson; Richard J Youle
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin.
PLoS biology 2010;8(1):e1000298.
2010: Azad Kumar; Elisa Greggio; Alexandra Beilina; Alice Kaganovich; Diane Chan; Jean-Marc Taymans; Benjamin Wolozin; Mark Cookson
The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation.
PloS one 2010;5(1):e8730.
2009: Casey O'Farrell; K L Martin; Michael Hutton; Martin Delatycki; Mark Cookson; P J Lockhart
Mutant torsinA interacts with tyrosine hydroxylase in cultured cells.
Neuroscience 2009;164(3):1127-37.
2009: Javier Simón-Sánchez; Claudia Schulte; Jose M Bras; Manu Sharma; J Raphael Gibbs; Daniela Berg; Coro Paisan-Ruiz; Peter Lichtner; Sonja W Scholz; Dena G Hernandez; Rejko Krüger; Monica Federoff; Christine Klein; Alison Goate; Joel Perlmutter; Michael Bonin; Michael A Nalls; Thomas Illig; Christian Gieger; Henry Houlden; Michael Steffens; Michael S Okun; Brad A Racette; Mark Cookson; Kelly D Foote; Hubert H Fernandez; Bryan Joseph Traynor; Stefan Schreiber; Sampath Arepalli; Ryan Zonozi; Katrina Gwinn-Hardy; Marcel van der Brug; Grisel Lopez; STEPHEN CHANOCK; Arthur Schatzkin; Yikyung Park; Albert Russell Hollenbeck; Jianjun Gao; Xuemei Huang; Nick W Wood; Delia Lorenz; Günther Deuschl; Honglei Chen; Olaf Riess; John Hardy; Andrew Singleton; Thomas Gasser
Genome-wide association study reveals genetic risk underlying Parkinson's disease.
Nature genetics 2009;41(12):1308-12.
2009: Yongchao Li; Laura Dunn; Elisa Greggio; Brian Krumm; Graham S Jackson; Mark Cookson; Patrick A Lewis; Junpeng Deng
The R1441C mutation alters the folding properties of the ROC domain of LRRK2.
Biochimica et biophysica acta 2009;1792(12):1194-7.
2009: Elisa Greggio; Jean-Marc Taymans; Eugene Yuejun Zhen; John Ryder; Renée Vancraenenbroeck; Alexandra Beilina; Peng Sun; Junpeng Deng; Howard Jaffe; Veerle Baekelandt; Kalpana Merchant; Mark Cookson
The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites.
Biochemical and biophysical research communications 2009;389(3):449-54.
2009: Kelly Jean Thomas; Mark Cookson
The role of PTEN-induced kinase 1 in mitochondrial dysfunction and dynamics.
The international journal of biochemistry & cell biology 2009;41(10):2025-35.
2009: Anna Sandebring; Nodi Dehvari; Monica Perez-Manso; Kelly Jean Thomas; Elena Karpilovski; Mark Cookson; Richard Frank Cowburn; Angel Cedazo-Mínguez
Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling.
The FEBS journal 2009;276(18):5041-52.
2009: Nodi Dehvari; Anna Sandebring; Amilcar Flores-Morales; Laura Mateos; Yin-Choy Chuan; Matthew S Goldberg; Mark Cookson; Richard Frank Cowburn; Angel Cedazo-Mínguez
Parkin-mediated ubiquitination regulates phospholipase C-gamma1.
Journal of cellular and molecular medicine 2009;13(9B):3061-8.
2009: W Haung Yu; Beatriz Dorado; Helen Yvette Figueroa; Lili Wang; Emmanuel Planel; Mark Cookson; Lorraine N Clark; karen duff
Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein.
The American journal of pathology 2009;175(2):736-47.
2009: Shamol Saha; Maria D Guillily; Andrew Ferree; Joel Lanceta; Diane Chan; Joy Ghosh; Cindy H Hsu; Lilach Segal; Kesav Raghavan; Kunihiro Matsumoto; Naoki Hisamoto; Tomoki Kuwahara; Takeshi Iwatsubo; Landon Moore; Lee Goldstein; Mark Cookson; Benjamin Wolozin
LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(29):9210-8.
2009: P M A Sleiman; Daniel G Healy; M M K Muqit; Y X Yang; M Van Der Brug; Janice L Holton; Tamas Revesz; Niall Quinn; K Bhatia; J K J Diss; Andrew J Lees; Mark Cookson; David S Latchman; Nicholas W Wood
Characterisation of a novel NR4A2 mutation in Parkinson's disease brain.
Neuroscience letters 2009;457(2):75-9.
2009: Zhihua Liu; Robin K Meray; Tom N Grammatopoulos; Ross A Fredenburg; Mark Cookson; Yichin Liu; Todd Logan; Peter T Lansbury
Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(12):4635-40.
2009: Andreas Weihofen; Kelly Jean Thomas; Beth L Ostaszewski; Mark Cookson; Dennis J Selkoe
Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking.
Biochemistry 2009;48(9):2045-52.
2009: Jeff Blackinton; Ravindran Kumaran; Marcel van der Brug; Rili Ahmad; Lars Olson; Dagmar Galter; Andrew J Lees; Rina Bandopadhyay; Mark Cookson
Post-transcriptional regulation of mRNA associated with DJ-1 in sporadic Parkinson disease.
Neuroscience letters 2009;452(1):8-11.
2009: Jeff Blackinton; Mahadevan Lakshminarasimhan; Kelly J Thomas; Rili Ahmad; Elisa Greggio; Ashraf S Raza; Mark Cookson; Mark A Wilson
Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1.
The Journal of biological chemistry 2009;284(10):6476-85.
2009: Elisa Greggio; Mark Cookson
Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions.
ASN neuro 2009;1(1):.
2009: Anna Sandebring; Kelly Jean Thomas; Alexandra Beilina; Marcel van der Brug; Megan Cleland; Rili Ahmad; David W Miller; Ibardo Zambrano; Richard Frank Cowburn; Homira Behbahani; Angel Cedazo-Mínguez; Mark Cookson
Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.
PloS one 2009;4(5):e5701.
2009: Mark Cookson
alpha-Synuclein and neuronal cell death.
Molecular neurodegeneration 2009;4():9.
2008: Jose Bras; Andrew Singleton; Mark Cookson; John Hardy
Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease.
The FEBS journal 2008;275(23):5767-73.
2008: Heather Mortiboys; Kelly Jean Thomas; Werner J H Koopman; Stefanie Klaffke; Patrick M Abou-Sleiman; Simon Olpin; Nicholas W Wood; Peter H G M Willems; Jan A M Smeitink; Mark Cookson; Oliver Bandmann
Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts.
Annals of neurology 2008;64(5):555-65.
2008: Marcel van der Brug; Jeff Blackinton; Jayanth Chandran; Ling-Yang Hao; Ashish Lal; Krystyna Mazan-Mamczarz; Jennifer L Martindale; Chengsong Xie; Rili Ahmad; Kelly J Thomas; Alexandra Beilina; J Raphael Gibbs; Jinhui Ding; Amanda Myers; Ming Zhan; Huaibin Cai; Nancy M Bonini; Myriam Gorospe; Mark Cookson
RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(29):10244-9.
2008: Elisa Greggio; Ibardo Zambrano; Alice Kaganovich; Alexandra Beilina; Jean-Marc Taymans; Veronique Daniëls; Patrick Lewis; Shushant Jain; Jinhui Ding; Ali Syed; Kelly J Thomas; Veerle Baekelandt; Mark Cookson
The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation.
The Journal of biological chemistry 2008;283(24):16906-14.
2008: Lizhen Wang; Chengsong Xie; Elisa Greggio; Loukia Parisiadou; Hoon Shim; Lixin Sun; Jayanth Chandran; Xian Lin; Chen Lai; Wan-Jou Yang; Darren J Moore; Ted M Dawson; Valina Dawson; Gabriela Chiosis; Mark Cookson; Huaibin Cai
The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(13):3384-91.
2008: Sarah Camargos; Sonja Scholz; Javier Simón-Sánchez; Coro Paisan-Ruiz; Patrick Lewis; Dena Hernandez; Jinhui Ding; J Raphael Gibbs; Mark Cookson; Jose Bras; Rita Guerreiro; Catarina R Oliveira; Andrew J Lees; John Hardy; Francisco Cardoso; Andrew Singleton
DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA.
Lancet neurology 2008;7(3):207-15.
2008: Junpeng Deng; Patrick A Lewis; Elisa Greggio; Eli Sluch; Alexandra Beilina; Mark Cookson
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(5):1499-504.
2008: M Emdadul Haque; Kelly J Thomas; Cheryl D'Souza; Steven M Callaghan; Tohru Kitada; ruth slack; Paul E Fraser; Mark Cookson; Anurag Tandon; David Park
Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(5):1716-21.
2008: Mark Cookson; John Hardy; Patrick A Lewis
Genetic neuropathology of Parkinson's disease.
International journal of clinical and experimental pathology 2008;1(3):217-31.
2008: Mark Cookson; Marcel van der Brug
Cell systems and the toxic mechanism(s) of alpha-synuclein.
Experimental neurology 2008;209(1):5-11.
2007: Jeff G Blackinton; Anna Anvret; Alexandra Beilina; Lars Olson; Mark Cookson; Dagmar Galter
Expression of PINK1 mRNA in human and rodent brain and in Parkinson's disease.
Brain research 2007;1184():10-6.
2007: Mark Cookson; William T Dauer; Ted M Dawson; Edward A Fon; Ming Guo; Jie Shen
The roles of kinases in familial Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(44):11865-8.
2007: Hyang-Sook Hoe; Matthew J Cooper; Mark Burns; Patrick A Lewis; Marcel van der Brug; Geetanjali Chakraborty; Casandra M Cartagena; Daniel T S Pak; Mark Cookson; G. William Rebeck
The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(40):10895-905.
2007: Elisa Greggio; Patrick A Lewis; Marcel van der Brug; Rili Ahmad; Alice Kaganovich; Jinhui Ding; Alexandra Beilina; Acacia K Baker; Mark Cookson
Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.
Journal of neurochemistry 2007;102(1):93-102.
2007: Patrick A Lewis; Elisa Greggio; Alexandra Beilina; Shushant Jain; Acacia Baker; Mark Cookson
The R1441C mutation of LRRK2 disrupts GTP hydrolysis.
Biochemical and biophysical research communications 2007;357(3):668-71.
2007: Joyce van de Leemput; Jayanth Chandran; Melanie A Knight; Lynne A Holtzclaw; Sonja Scholz; Mark Cookson; Henry Houlden; Katrina Gwinn-Hardy; Hon-Chung Fung; Xian Lin; Dena Hernandez; Javier Simon-Sanchez; Nicholas W Wood; Paola Giunti; Ian Rafferty; John Hardy; Elsdon Storey; R J McKinlay Gardner; Susan M Forrest; Elizabeth M C Fisher; James T Russell; Huaibin Cai; Andrew Singleton
Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans.
PLoS genetics 2007;3(6):e108.
2007: Stephanie C Pero; Girja S Shukla; Mark Cookson; S Flemer; David N Krag
Combination treatment with Grb7 peptide and Doxorubicin or Trastuzumab (Herceptin) results in cooperative cell growth inhibition in breast cancer cells.
British journal of cancer 2007;96(10):1520-5.
2006: Mark Cookson; John Hardy
The persistence of memory.
The New England journal of medicine 2006;355(25):2697-8.
2006: Chen Lai; Chengsong Xie; Stefanie G McCormack; Hsueh-Cheng Chiang; Marta K Michalak; Xian Lin; Jayanth Chandran; Hoon Shim; Mika Shimoji; Mark Cookson; Richard Huganir; Jeffrey rothstein; Donald L Price; Philip C Wong; Lee J Martin; J Julius Zhu; Huaibin Cai
Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(45):11798-806.
2006: John Hardy; Huaiban Cai; Mark Cookson; Katrina Gwinn-Hardy; Andrew Singleton
Genetics of Parkinson's disease and parkinsonism.
Annals of neurology 2006;60(4):389-98.
2006: Elisa Greggio; Shushant Jain; Ann E Kingsbury; Rina Bandopadhyay; Patrick Lewis; Alice Kaganovich; Marcel van der Brug; Alexandra Beilina; Jeff Blackinton; Kelly Jean Thomas; Rili Ahmad; David W Miller; Sashi Kesavapany; Andrew Singleton; Andrew J Lees; Robert Justin Harvey; Kirsten Harvey; Mark Cookson
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin.
Neurobiology of disease 2006;23(2):329-41.
2006: Mark Cookson
Hero versus antihero: the multiple roles of alpha-synuclein in neurodegeneration.
Experimental neurology 2006;199(2):238-42.
2006: Ranjita Betarbet; Canet Rosa; Todd B Sherer; Pier G Mastroberardino; Chris McLendon; Jin-Ho Kim; Serena Lund; Hye-Mee Na; Georgia Taylor; Neil F Bence; Ron Kopito; Byoung Boo Seo; Takao Yagi; Akemi Yagi; Gary Klinefelter; Mark Cookson; J Timothy Greenamyre
Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system.
Neurobiology of disease 2006;22(2):404-20.
2006: Parastoo Momeni; Jennifer C Schymick; Shushant Jain; Mark Cookson; Nigel J Cairns; Elisa Greggio; Matthew J Greenway; Stephen Berger; Stuart Pickering-Brown; Adriano Chio; Hon-Chung Fung; David M Holtzman; Edward D Huey; Eric M Wassermann; Jennifer Adamson; Michael Hutton; Ekaterina Rogaeva; Peter St George-Hyslop; Jeffrey rothstein; Orla Hardiman; Jordan Grafman; Andrew Singleton; John Hardy; Bryan Joseph Traynor
Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD.
BMC neurology 2006;6():44.
2005: Mark Cookson; Jordi Clarimon
Dystonia and the nuclear envelope.
Neuron 2005;48(6):875-7.
2005: Mark Cookson; Georgia Xiromerisiou; Andrew Singleton
How genetics research in Parkinson's disease is enhancing understanding of the common idiopathic forms of the disease.
Current opinion in neurology 2005;18(6):706-11.
2005: Mark Cookson
Neurons inflict self-harm.
Nature medicine 2005;11(11):1159-61.
2005: Rina Bandopadhyay; David W Miller; Ann E Kingsbury; Terry P Jowett; Mona Kaleem; Alan Pittman; Rohan de Silva; Mark Cookson; Andrew J Lees
Development, characterisation and epitope mapping of novel monoclonal antibodies for DJ-1 (PARK7) protein.
Neuroscience letters 2005;383(3):225-30.
2005: Alexandra Beilina; Marcel van der Brug; Rili Ahmad; Sashi Kesavapany; David W Miller; Gregory A Petsko; Mark Cookson
Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(16):5703-8.
2005: Elisa Greggio; Elisabetta Bergantino; Donald Carter; Rili Ahmad; Gertrude-E Costin; Vincent J Hearing; Jordi Clarimon; Andrew Singleton; Johanna Eerola; Olli Hellström; Pentti J Tienari; David W Miller; Alexandra Beilina; Luigi Bubacco; Mark Cookson
Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease.
Journal of neurochemistry 2005;93(1):246-56.
2005: Jeff Blackinton; Rili Ahmad; David W Miller; Marcel van der Brug; Canet Rosa; Stephen Hague; Mona Kaleem; Mark Cookson
Effects of DJ-1 mutations and polymorphisms on protein stability and subcellular localization.
Brain research. Molecular brain research 2005;134(1):76-83.
2005: David W Miller; Carmen R Wilson; Mona Kaleem; Jeff Blackinton; Mark Cookson
Identification of the epitope of a monoclonal antibody to DJ-1.
Neuroscience letters 2005;374(3):203-6.
2005: David W Miller; Anthony Crawley; Katrina Gwinn-Hardy; Grisel Lopez; Robert L Nussbaum; Mark Cookson; Andrew Singleton; John Hardy; Okan Dogu
Unaltered alpha-synuclein blood levels in juvenile Parkinsonism with a parkin exon 4 deletion.
Neuroscience letters 2005;374(3):189-91.
2005: Mark Cookson
The biochemistry of Parkinson's disease.
Annual review of biochemistry 2005;74():29-52.
2004: Mark Cookson
Molecules that cause or prevent Parkinson's disease.
PLoS biology 2004;2(11):e401.
2004: Mark Cookson
Roles of the proteasome in neurodegenerative disease: refining the hypothesis.
Annals of neurology 2004;56(3):315-6.
2004: Casey O'Farrell; Paul J Lockhart; Sarah J Lincoln; Michael De Lucia; Andrew Singleton; dennis dickson; Mark Cookson
Biochemical characterization of torsinB.
Brain research. Molecular brain research 2004;127(1-2):1-9.
2004: Jie Shen; Mark Cookson
Mitochondria and dopamine: new insights into recessive parkinsonism.
Neuron 2004;43(3):301-4.
2004: Omar M A El-Agnaf; Katerina E Paleologou; Brett Greer; Abdulmawala M Abogrein; Jenny E King; Sultan A Salem; Nigel J Fullwood; Fiona E Benson; Rebecca Hewitt; Kirstie J Ford; Francis L Martin; Patrick Harriott; Mark Cookson; David Allsop
A strategy for designing inhibitors of alpha-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(11):1315-7.
2004: Canet Rosa; Mark A Wilson; David W Miller; Rili Ahmad; Chris McLendon; Sourav Bandyopadhyay; Melisa J Baptista; Dagmar Ringe; Gregory A Petsko; Mark Cookson
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(24):9103-8.
2004: David W Miller; Stephen Hague; Jordi Clarimon; Melisa J Baptista; Katrina Gwinn-Hardy; Mark Cookson; Andrew Singleton
Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication.
Neurology 2004;62(10):1835-8.
2004: Sourav Bandyopadhyay; Mark Cookson
Evolutionary and functional relationships within the DJ1 superfamily.
BMC evolutionary biology 2004;4():6.
2004: Melisa J Baptista; Mark Cookson; David W Miller
Parkin and alpha-synuclein: opponent actions in the pathogenesis of Parkinson's disease.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2004;10(1):63-72.
2004: Rina Bandopadhyay; Ann E Kingsbury; Mark Cookson; Andrew R Reid; Ian Evans; Andrew D Hope; Alan Pittman; Tammaryn Lashley; Canet Rosa; David W Miller; Chris McLendon; Catherine Strand; Andrew J Leonard; Patrick M Abou-Sleiman; Daniel G Healy; Hiroyashi Ariga; Nicholas W Wood; Rohan de Silva; Tamas Revesz; John Hardy; Andrew J Lees
The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease.
Brain : a journal of neurology 2004;127(Pt 2):420-30.
2004: Melisa J Baptista; Casey O'Farrell; Mark Cookson
Dominant torsinA mutations in cellular systems.
Advances in neurology 2004;94():73-8.
2003: Mark Cookson; Paul J Lockhart; Chris McLendon; Casey O'Farrell; Michael G Schlossmacher; Matthew J Farrer
RING finger 1 mutations in Parkin produce altered localization of the protein.
Human molecular genetics 2003;12(22):2957-65.
2003: Andrew B Singleton; Matthew J Farrer; Janel Johnson; Andrew Singleton; Stephen Hague; Jennifer Kachergus; Mary Hulihan; Terhi Peuralinna; A Dutra; Robert L Nussbaum; Sarah J Lincoln; Anthony Crawley; Melissa Hanson; Demetrius M Maraganore; Charles H Adler; Mark Cookson; MD Muenter; Melisa J Baptista; D Miller; J Blancato; John Hardy; Katrina Gwinn-Hardy
alpha-Synuclein locus triplication causes Parkinson's disease.
Science (New York, N.Y.) 2003;302(5646):841.
2003: Omar M A El-Agnaf; Sultan A Salem; Katerina E Paleologou; Leanne J Cooper; Nigel J Fullwood; Mark J Gibson; Martin D Curran; Jennifer A Court; D M A Mann; Shu-ichi Ikeda; Mark Cookson; John Hardy; David Allsop
Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(13):1945-7.
2003: David W Miller; Rili Ahmad; Stephen Hague; Melisa J Baptista; Canet Rosa; Chris McLendon; Donald M Carter; Peng-Peng Zhu; Julia Stadler; Jayanth Chandran; Gary R Klinefelter; Craig Blackstone; Mark Cookson
L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system.
The Journal of biological chemistry 2003;278(38):36588-95.
2003: Mark Cookson
Crystallizing ideas about Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9111-3.
2003: Mark Cookson
Neurodegeneration: how does parkin prevent Parkinson's disease?
Current biology : CB 2003;13(13):R522-4.
2003: Frank P Marx; Carsten Holzmann; Karsten M Strauss; Lei Li; Olaf Eberhardt; Ellen Gerhardt; Mark Cookson; Dena Hernandez; Matthew J Farrer; Jennifer Kachergus; Simone Engelender; Christopher A Ross; Klaus Berger; Ludger Schöls; Jörg B Schulz; Olaf Riess; Rejko Krüger
Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease.
Human molecular genetics 2003;12(11):1223-31.
2003: Melisa J Baptista; Casey O'Farrell; John Hardy; Mark Cookson
Microarray analysis reveals induction of heat shock proteins mRNAs by the torsion dystonia protein, TorsinA.
Neuroscience letters 2003;343(1):5-8.
2003: Melisa J Baptista; Casey O'Farrell; Sneha Daya; Rili Ahmad; David W Miller; John Hardy; Matthew J Farrer; Mark Cookson
Co-ordinate transcriptional regulation of dopamine synthesis genes by alpha-synuclein in human neuroblastoma cell lines.
Journal of neurochemistry 2003;85(4):957-68.
2003: John Hardy; Mark Cookson; Andrew Singleton
Genes and parkinsonism.
Lancet neurology 2003;2(4):221-8.
2003: Simon Allen; Paul R Heath; Janine Kirby; Stephen Barrie Wharton; Mark Cookson; Fiona M Menzies; Rosamonde Elizabeth Banks; Pamela Jean Shaw
Analysis of the cytosolic proteome in a cell culture model of familial amyotrophic lateral sclerosis reveals alterations to the proteasome, antioxidant defenses, and nitric oxide synthetic pathways.
The Journal of biological chemistry 2003;278(8):6371-83.
2003: Mark Cookson
Pathways to Parkinsonism.
Neuron 2003;37(1):7-10.
2003: Mark Cookson
Parkin's substrates and the pathways leading to neuronal damage.
Neuromolecular medicine 2003;3(1):1-13.
2002: Carmen Martin-Ruiz; S Lawrence; Margaret A Piggott; Alexander Kuryatov; Jon Lindstrom; Cecilia Gotti; Mark Cookson; Robert H Perry; Evelyn Jaros; Elaine K Perry; Jennifer A Court
Nicotinic receptors in the putamen of patients with dementia with Lewy bodies and Parkinson's disease: relation to changes in alpha-synuclein expression.
Neuroscience letters 2002;335(2):134-8.
2002: Leonard Petrucelli; Casey O'Farrell; Paul J Lockhart; Melisa J Baptista; Kathryn Kehoe; Liselot Vink; Peter Choi; Benjamin Wolozin; Matthew J Farrer; John Hardy; Mark Cookson
Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons.
Neuron 2002;36(6):1007-19.
2002: Fiona M Menzies; andy grierson; Mark Cookson; Paul R Heath; Janine Tomkins; Denise A Figlewicz; Paul Geoffrey Ince; Pamela J Shaw
Selective loss of neurofilament expression in Cu/Zn superoxide dismutase (SOD1) linked amyotrophic lateral sclerosis.
Journal of neurochemistry 2002;82(5):1118-28.
2002: Todd B Sherer; Ranjita Betarbet; Amy K Stout; Serena Lund; Melisa J Baptista; Alexander V Panov; Mark Cookson; J Timothy Greenamyre
An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(16):7006-15.
2002: Janine Kirby; Fiona M Menzies; Mark Cookson; Kate Bushby; Pamela J Shaw
Differential gene expression in a cell culture model of SOD1-related familial motor neurone disease.
Human molecular genetics 2002;11(17):2061-75.
2002: Casey O'Farrell; Dena G Hernandez; Crystal Evey; Andrew Singleton; Mark Cookson
Normal localization of deltaF323-Y328 mutant torsinA in transfected human cells.
Neuroscience letters 2002;327(2):75-8.
2002: Fiona M Menzies; Mark Cookson; Robert W Taylor; Douglass M Turnbull; Zofia M A Chrzanowska-Lightowlers; Lichun Dong; Denise A Figlewicz; Pamela J Shaw
Mitochondrial dysfunction in a cell culture model of familial amyotrophic lateral sclerosis.
Brain : a journal of neurology 2002;125(Pt 7):1522-33.
2002: Mark Cookson; Fiona M Menzies; Philip Manning; Christopher J Eggett; Denise A Figlewicz; Calum J McNeil; Pamela J Shaw
Cu/Zn superoxide dismutase (SOD1) mutations associated with familial amyotrophic lateral sclerosis (ALS) affect cellular free radical release in the presence of oxidative stress.
Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 2002;3(2):75-85.
2002: Casey O'Farrell; Fiona Pickford; Liselot Vink; Eileen McGowan; Mark Cookson
Sequence conservation between mouse and human synphilin-1.
Neuroscience letters 2002;322(1):9-12.
2002: Steve Banner; AE Fray; Paul Geoffrey Ince; M Steward; Mark Cookson; Pamela J Shaw
The expression of the glutamate re-uptake transporter excitatory amino acid transporter 1 (EAAT1) in the normal human CNS and in motor neurone disease: an immunohistochemical study.
Neuroscience 2002;109(1):27-44.
2001: Casey O'Farrell; D D Murphy; Leonard Petrucelli; Andrew Singleton; Jennifer Hussey; Matthew J Farrer; John Hardy; dennis dickson; Mark Cookson
Transfected synphilin-1 forms cytoplasmic inclusions in HEK293 cells.
Brain research. Molecular brain research 2001;97(1):94-102.
2001: AE Fray; S Dempster; R E Williams; Mark Cookson; Pamela J Shaw
Glutamine synthetase activity and expression are not affected by the development of motor neuronopathy in the G93A SOD-1/ALS mouse.
Brain research. Molecular brain research 2001;94(1-2):131-6.
2001: Johanna M H Anneser; Mark Cookson; Paul Geoffrey Ince; Pamela J Shaw; Gian Domenico Borasio
Glial cells of the spinal cord and subcortical white matter up-regulate neuronal nitric oxide synthase in sporadic amyotrophic lateral sclerosis.
Experimental neurology 2001;171(2):418-21.
2001: Andrew West; Matthew J Farrer; Leonard Petrucelli; Mark Cookson; Paul Lockhart; John Hardy
Identification and characterization of the human parkin gene promoter.
Journal of neurochemistry 2001;78(5):1146-52.
2001: Philip Manning; Mark Cookson; Calum J McNeil; D Figlewicz; Pamela J Shaw
Superoxide-induced nitric oxide release from cultured glial cells.
Brain research 2001;911(2):203-10.
2001: R E Williams; Mark Cookson; AE Fray; P M Manning; Fiona M Menzies; Denise A Figlewicz; Pamela J Shaw
Cultured glial cells are resistant to the effects of motor neurone disease-associated SOD1 mutations.
Neuroscience letters 2001;302(2-3):146-50.
2000: K D White; Paul Geoffrey Ince; Meryl E Lusher; J Lindsey; Mark Cookson; Rumaisa Bashir; Pamela J Shaw; K M D Bushby
Clinical and pathologic findings in hereditary spastic paraparesis with spastin mutation.
Neurology 2000;55(1):89-94.
2000: Janine Tomkins; S Dempster; Steve Banner; Mark Cookson; Pamela J Shaw
Screening of AP endonuclease as a candidate gene for amyotrophic lateral sclerosis (ALS).
Neuroreport 2000;11(8):1695-7.
2000: C J Eggett; Stephen Crosier; Philip Manning; Mark Cookson; Fiona M Menzies; Calum J McNeil; Pamela J Shaw
Development and characterisation of a glutamate-sensitive motor neurone cell line.
Journal of neurochemistry 2000;74(5):1895-902.
2000: Mark Cookson
Update on transrectal ultrasound-guided needle biopsy of the prostate.
Molecular urology 2000;4(3):93-7; discussion 99.
1999: Mark Cookson; Paul Geoffrey Ince; PA Usher; Pamela J Shaw
Poly(ADP-ribose) polymerase is found in both the nucleus and cytoplasm of human CNS neurons.
Brain research 1999;834(1-2):182-5.
1999: AM Amos; W M Figlesthaler; Mark Cookson
Bilateral ureteritis cystica with unilateral ureteropelvic junction obstruction.
Techniques in urology 1999;5(2):108-12.
1999: Mark Cookson; Pamela J Shaw
Oxidative stress and motor neurone disease.
Brain pathology (Zurich, Switzerland) 1999;9(1):165-86.
1998: Farhang Rabbani; N Stroumbakis; Bruce R Kava; Mark Cookson; W R Fair
[Incidence and clinical significance of false-negative sextant biopsies of the prostate].
Der Urologe. Ausg. A 1998;37(6):660.
1998: AE Fray; Paul Geoffrey Ince; Steve Banner; Ian D Milton; PA Usher; Mark Cookson; Pamela J Shaw
The expression of the glial glutamate transporter protein EAAT2 in motor neuron disease: an immunohistochemical study.
The European journal of neuroscience 1998;10(8):2481-9.
1998: Mark Cookson; ND Slamon; VW Pentreath
Glutathione modifies the toxicity of triethyltin and trimethyltin in C6 glioma cells.
Archives of toxicology 1998;72(4):197-202.
1998: Mark Cookson; Paul Geoffrey Ince; P J Shaw
Peroxynitrite and hydrogen peroxide induced cell death in the NSC34 neuroblastoma x spinal cord cell line: role of poly (ADP-ribose) polymerase.
Journal of neurochemistry 1998;70(2):501-8.
1996: Mark Cookson; N M Thatcher; Paul Geoffrey Ince; Pamela J Shaw
Selective loss of neurofilament proteins after exposure of differentiated human IMR-32 neuroblastoma cells to oxidative stress.
Brain research 1996;738(1):162-6.
1996: Mark Cookson; V W Pentreath
Protective roles of glutathione in the toxicity of mercury and cadmium compounds to C6 glioma cells.
Toxicology in vitro : an international journal published in association with BIBRA 1996;10(3):257-64.
1995: Mark Cookson; C Mead; S M Austwick; V W Pentreath
Use of the MTT assay for estimating toxicity in primary astrocyte and C6 glioma cell cultures.
Toxicology in vitro : an international journal published in association with BIBRA 1995;9(1):39-48.
1995: Mark Cookson; R McClean; VW Pentreath
Preparation and use of cultured astrocytes for assay of gliotoxicity.
Methods in molecular biology (Clifton, N.J.) 1995;43():17-23.
1994: Mark Cookson; R McClean; S P Williams; J Davenport-Jones; C Egan; S O'Hare; C K Atterwill; VW Pentreath
Use of astrocytes for in vitro neurotoxicity testing.
Toxicology in vitro : an international journal published in association with BIBRA 1994;8(4):817-9.
1994: S P Williams; JE Davenport Jones; C Egan; S O'Hare; Mark Cookson; R McClean; M J Garle; V Pentreath; C K Atterwill
Phase 1 of an in vitro neurotoxicological pre-validation trial.
Toxicology in vitro : an international journal published in association with BIBRA 1994;8(4):799-802.
1994: Mark Cookson; VW Pentreath
Alterations in the glial fibrillary acidic protein content of primary astrocyte cultures for evaluation of glial cell toxicity.
Toxicology in vitro : an international journal published in association with BIBRA 1994;8(3):351-9.
1994: E E Houser; T H Bartholomew; Mark Cookson; A E Marlin; N A Little
A prospective evaluation of leak point pressure, bladder compliance and clinical status in myelodysplasia patients with tethered spinal cords.
The Journal of urology 1994;151(1):177-80; discussion 180-1.
1994: R A Alafiatayo; Mark Cookson; VW Pentreath
Production of prostaglandins D2 and E2 by mouse fibroblasts and astrocytes in culture caused by Trypanosoma brucei brucei products and endotoxin.
Parasitology research 1994;80(3):223-9.
1994: VW Pentreath; Mark Cookson; G A Ingram; C Mead; R A Alafiatayo
Trypanosoma brucei products activate components of the reactive response in astrocytes in vitro.
Bulletin de la Société de pathologie exotique (1990) 1994;87(5):323-9.