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Richard Williams

Research Profile

Anatomy

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Publications

TOP 3
Richard Williams
IL3 receptor-dependent therapeutic targeting of BCR-ABL-driven lymphoid leukemias.
Mark A Gregory; Tzu L Phang; Paolo Neviani; Francesca Alvarez-Calderon; Christopher A Eide; Thomas O'Hare; Vadym Zaberezhnyy; Richard Williams; Brian J Druker; Danilo Perrotti; James DeGregori
Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl.
Emmanuel J Volanakis; Richard Williams; Charles J Sherr
Stage-specific Arf tumor suppression in Notch1-induced T-cell acute lymphoblastic leukemia.

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All Publications

2010: Richard Williams
IL3 receptor-dependent therapeutic targeting of BCR-ABL-driven lymphoid leukemias.
Leukemia research 2010;34(8):963-4.
2010: Mark A Gregory; Tzu L Phang; Paolo Neviani; Francesca Alvarez-Calderon; Christopher A Eide; Thomas O'Hare; Vadym Zaberezhnyy; Richard Williams; Brian J Druker; Danilo Perrotti; James DeGregori
Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl.
Cancer cell 2010;18(1):74-87.
2009: Emmanuel J Volanakis; Richard Williams; Charles J Sherr
Stage-specific Arf tumor suppression in Notch1-induced T-cell acute lymphoblastic leukemia.
Blood 2009;114(20):4451-9.
2009: Charles G Mullighan; J Racquel Collins-Underwood; Letha A A Phillips; Michael G Loudin; Wei Liu; Jinghui Zhang; Jing Ma; Elaine Coustan-Smith; Richard C Harvey; Cheryl L Willman; Fady M Mikhail; Julia Meyer; Andrew J Carroll; Richard Williams; Jinjun Cheng; Nyla A Heerema; Giuseppe Basso; Andrea Pession; Ching-Hon Pui; Susana C Raimondi; Stephen P Hunger; James R Downing; William L Carroll; Karen Rabin
Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia.
Nature genetics 2009;41(11):1243-6.
2008: Richard Williams; Charles J Sherr
BCR-ABL and CDKN2A: a dropped connection.
Nature reviews. Cancer 2008;8(7):563; author reply 563.
2008: Charles G Mullighan; Richard Williams; James R Downing; Charles J Sherr
Failure of CDKN2A/B (INK4A/B-ARF)-mediated tumor suppression and resistance to targeted therapy in acute lymphoblastic leukemia induced by BCR-ABL.
Genes & development 2008;22(11):1411-5.
2008: Richard Williams; C J Sherr
The INK4-ARF (CDKN2A/B) locus in hematopoiesis and BCR-ABL-induced leukemias.
Cold Spring Harbor symposia on quantitative biology 2008;73():461-7.
2007: Richard Williams; Willem den Besten; Charles J Sherr
Cytokine-dependent imatinib resistance in mouse BCR-ABL+, Arf-null lymphoblastic leukemia.
Genes & development 2007;21(18):2283-7.
2007: Richard Williams; Charles J Sherr
The ARF tumor suppressor in acute leukemias: insights from mouse models of Bcr-Abl-induced acute lymphoblastic leukemia.
Advances in experimental medicine and biology 2007;604():107-14.
2006: Richard Williams; Martine F Roussel; Charles J Sherr
Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(17):6688-93.
2006: Willem den Besten; Mei-Ling Kuo; Kenji Tago; Richard Williams; Charles J Sherr
Ubiquitination of, and sumoylation by, the Arf tumor suppressor.
The Israel Medical Association journal : IMAJ 2006;8(4):249-51.
2005: Willem den Besten; Mei-Ling Kuo; Richard Williams; Charles J Sherr
Myeloid leukemia-associated nucleophosmin mutants perturb p53-dependent and independent activities of the Arf tumor suppressor protein.
Cell cycle (Georgetown, Tex.) 2005;4(11):1593-8.
2005: Charles J Sherr; David Bertwistle; Willem den Besten; Mei-Ling Kuo; Masataka Sugimoto; Kenji Tago; Richard Williams; Frederique Zindy; Martine F Roussel
p53-Dependent and -independent functions of the Arf tumor suppressor.
Cold Spring Harbor symposia on quantitative biology 2005;70():129-37.
2003: Frederique Zindy; Richard Williams; Troy A Baudino; Jerold E Rehg; Stephen Xavier Skapek; John L Cleveland; Martine F Roussel; Charles J Sherr
Arf tumor suppressor promoter monitors latent oncogenic signals in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15930-5.
2002: Richard Williams; Paul V Senior; Leonie Van Stekelenburg; Judith E Layton; Peter J Smith; Marie A Dziadek
Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation.
Biochimica et biophysica acta 2002;1596(1):131-7.
2001: Richard Williams; SS Manji; NJ Parker; M S Hancock; Leonie Van Stekelenburg; J P Eid; Paul V Senior; J S Kazenwadel; Tetyana Shandala; Robert Saint; Peter J Smith; Marie A Dziadek
Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins.
The Biochemical journal 2001;357(Pt 3):673-85.
2000: SS Manji; NJ Parker; Richard Williams; Leonie Van Stekelenburg; Richard B Pearson; Marie A Dziadek; Peter J Smith
STIM1: a novel phosphoprotein located at the cell surface.
Biochimica et biophysica acta 2000;1481(1):147-55.
1997: Katarzyna Magdalena Dziegielewska; Richard Williams; Graham W Knott; Peter D Kitchener; S E Monk; A Potter; Norman Ruthven Saunders
TGF-beta receptor type II and fetuin in the developing sheep neocortex.
Cell and tissue research 1997;290(3):515-24.
1997: T Wei; Richard Williams; Martin F Lavin
Activation of cyclin A-dependent kinases associated with WAF1 degradation during radiation-induced apoptosis.
Cell death and differentiation 1997;4(4):276-82.
1996: H Beamish; Richard Williams; Philip Chen; Kum Kum Khanna; Karen Hobson; Dianne Watters; Yosef Shiloh; Martin Lavin
Rapamycin resistance in ataxia-telangiectasia.
Oncogene 1996;13(5):963-70.
1996: H Beamish; Richard Williams; Philip Chen; Martin F Lavin
Defect in multiple cell cycle checkpoints in ataxia-telangiectasia postirradiation.
The Journal of biological chemistry 1996;271(34):20486-93.
1996: Frederick L Hall; P D Benya; S R Padilla; D Carbonaro-Hall; Richard Williams; Sue Buckley; David Warburton
Transforming growth factor-beta type-II receptor signalling: intrinsic/associated casein kinase activity, receptor interactions and functional effects of blocking antibodies.
The Biochemical journal 1996;316 ( Pt 1)():303-10.
1995: Kum Kum Khanna; H Beamish; J Yan; Karen Hobson; Richard Williams; I Dunn; Martin F Lavin
Nature of G1/S cell cycle checkpoint defect in ataxia-telangiectasia.
Oncogene 1995;11(4):609-18.
1995: W K Liu; Richard Williams; Frederick L Hall; dennis dickson; Shu-Hui C. Yen
Detection of a Cdc2-related kinase associated with Alzheimer paired helical filaments.
The American journal of pathology 1995;146(1):228-38.
1995: Margarita Zeichner-David; F Hall; Richard Williams; F Thiemann; S Yen; Mary MacDougall; Harold Charles Slavkin
Characterization of protein kinases involved in dentinogenesis.
Connective tissue research 1995;33(1-3):87-95.
1994: Richard Williams; Lingtao Wu; D A Carbonaro-Hall; Frederick L Hall
Identification, assay, and purification of a Cdc2-activating threonine-161 protein kinase from human cells.
Archives of biochemistry and biophysics 1994;314(1):99-106.
1994: Bela Bodey; Richard Williams; D A Carbonaro-Hall; A Horvath; Vernon T Tolo; J V Luck; C R Taylor; Frederick L Hall
Immunocytochemical detection of cyclin A and cyclin D in formalin-fixed, paraffin-embedded tissues: novel, pertinent markers of cell proliferation.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1994;7(8):846-52.
1994: M Dohadwala; E F da Cruz e Silva; Frederick L Hall; Richard Williams; D A Carbonaro-Hall; Angus Nairn; Paul Greengard; Norbert Berndt
Phosphorylation and inactivation of protein phosphatase 1 by cyclin-dependent kinases.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(14):6408-12.
1993: M W Albers; E J Brown; A Tanaka; Richard Williams; Frederick L Hall; Stuart L Schreiber
An FKBP-rapamycin-sensitive, cyclin-dependent kinase activity that correlates with the FKBP-rapamycin-induced G1 arrest point in MG-63 cells.
Annals of the New York Academy of Sciences 1993;696():54-62.
1993: M W Albers; Richard Williams; E J Brown; A Tanaka; Frederick L Hall; Stuart L Schreiber
FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line.
The Journal of biological chemistry 1993;268(30):22825-9.
1993: Richard Williams; J Sanghera; F Wu; D Carbonaro-Hall; D L Campbell; David Warburton; S Pelech; F Hall
Identification of a human epidermal growth factor receptor-associated protein kinase as a new member of the mitogen-activated protein kinase/extracellular signal-regulated protein kinase family.
The Journal of biological chemistry 1993;268(24):18213-7.
1993: K C Bui; F Wu; Sue Buckley; Lingtao Wu; Richard Williams; D Carbonaro-Hall; Frederick L Hall; David Warburton
Cyclin A expression in normal and transformed alveolar epithelial cells.
American journal of respiratory cell and molecular biology 1993;9(2):115-25.
1993: D Carbonaro-Hall; Richard Williams; Lingtao Wu; David Warburton; Margarita Zeichner-David; M MacDougall; Vernon T Tolo; F Hall
G1 expression and multistage dynamics of cyclin A in human osteosarcoma cells.
Oncogene 1993;8(6):1649-59.
1993: Frederick L Hall; Richard Williams; Lingtao Wu; F Wu; D A Carbonaro-Hall; J W Harper; David Warburton
Two potentially oncogenic cyclins, cyclin A and cyclin D1, share common properties of subunit configuration, tyrosine phosphorylation and physical association with the Rb protein.
Oncogene 1993;8(5):1377-84.
1993: Richard Williams; Lingtao Wu; D A Carbonaro-Hall; Vernon T Tolo; Frederick L Hall
Identification of a novel cyclin-like protein in human tumor cells.
The Journal of biological chemistry 1993;268(12):8871-80.
1993: W K Liu; W T Moore; Richard Williams; Frederick L Hall; Shu-Hui C. Yen
Application of synthetic phospho- and unphospho- peptides to identify phosphorylation sites in a subregion of the tau molecule, which is modified in Alzheimer's disease.
Journal of neuroscience research 1993;34(3):371-6.
1992: Stephen J Elledge; Ronald Richman; Frederick L Hall; Richard Williams; N Lodgson; J Wade Harper
CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):2907-11.
1992: Richard Williams; D A Carbonaro-Hall; Frederick L Hall
Co-purification of p34cdc2/p58cyclin A proline-directed protein kinase and the retinoblastoma tumor susceptibility gene product: interaction of an oncogenic serine/threonine protein kinase with a tumor-suppressor protein.
Oncogene 1992;7(3):423-32.