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Serge Przedborski

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Rosa L A de Vries; Serge Przedborski
Mitophagy and Parkinson's disease: be eaten to stay healthy.
Gilbert Di Paolo; Serge Przedborski
When Schwann cells conspire with mitochondria, neighboring axons are under attack by glia-derived neurotoxic lipids.
Etienne C Hirsch; Peter Jenner; Serge Przedborski
Pathogenesis of Parkinson's disease.

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All Publications

2013: Rosa L A de Vries; Serge Przedborski
Mitophagy and Parkinson's disease: be eaten to stay healthy.
Molecular and cellular neurosciences 2013;55():37-43.
2013: Gilbert Di Paolo; Serge Przedborski
When Schwann cells conspire with mitochondria, neighboring axons are under attack by glia-derived neurotoxic lipids.
Neuron 2013;77(5):801-3.
2013: Etienne C Hirsch; Peter Jenner; Serge Przedborski
Pathogenesis of Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2013;28(1):24-30.
2012: Yang D Teng; Dou Yu; Susanna C Benn; Robert H Brown; Bin Cheng; Kadir Erkmen; Inbo Han; Steven N Kalkanis; Mahesh B Lachyankar; Jianxue Li; Jeronia Lládo; Nicholas J Maragakis; Michael Marconi; Renna C Onario; Serge Przedborski; D Eugene Redmond; Jeffrey rothstein; Jeremy M Shefner; Richard L Sidman; Evan Y Snyder
Multimodal actions of neural stem cells in a mouse model of ALS: a meta-analysis.
Science translational medicine 2012;4(165):165ra164.
2012: Shingo Kariya; Katelyn Nelson; Serge Przedborski; Diane B Re; Arnaud Jacquier; Umrao R Monani
Mutant superoxide dismutase 1 (SOD1), a cause of amyotrophic lateral sclerosis, disrupts the recruitment of SMN, the spinal muscular atrophy protein to nuclear Cajal bodies.
Human molecular genetics 2012;21(15):3421-34.
2012: Luis E Gonzalez-Reyes; Vernice Jackson-Lewis; Javier Blesa; Edgar R Kramer; Daniel Paredes; Sudarshan Phani; Serge Przedborski; Karsten Tillack; Miguel Verbitsky; Andreas Kottmann
Sonic hedgehog maintains cellular and neurochemical homeostasis in the adult nigrostriatal circuit.
Neuron 2012;75(2):306-19.
2012: Dorothea Becker; Serge Przedborski; Judith Richter; Maja A Tocilescu; Wolfgang Voos
Pink1 kinase and its membrane potential (Deltaψ)-dependent cleavage product both localize to outer mitochondrial membrane by unique targeting mode.
The Journal of biological chemistry 2012;287(27):22969-87.
2012: Rosa L A de Vries; Robert W Gilkerson; Serge Przedborski; Eric A Schon
Mitophagy in cells with mtDNA mutations: being sick is not enough.
Autophagy 2012;8(4):699-700.
2012: Robert W Gilkerson; Paul Lebot; Serge Przedborski; Orian S Shirihai; Edina Torgyekes; Jakob D Wikstrom; Rosa L A De Vries; Eric A Schon
Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition.
Human molecular genetics 2012;21(5):978-90.
2012: Sudarshan Phani; Diane Berengere Re; Serge Przedborski
The Role of the Innate Immune System in ALS.
Frontiers in pharmacology 2012;3():150.
2012: Javier Blesa; Vernice Jackson-Lewis; Sudarshan Phani; Serge Przedborski
Classic and new animal models of Parkinson's disease.
Journal of biomedicine & biotechnology 2012;2012():845618.
2011: Serge Przedborski
Can we reverse alpha-synuclein lesions?
Movement disorders : official journal of the Movement Disorder Society 2011;26(9):1618.
2011: Eric A Schon; Serge Przedborski
Mitochondria: the next (neurode)generation.
Neuron 2011;70(6):1033-53.
2011: Erwan Bezard; Serge Przedborski
A tale on animal models of Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2011;26(6):993-1002.
2011: Cristofol Vives-Bauza; Serge Przedborski
Mitophagy: the latest problem for Parkinson's disease.
Trends in molecular medicine 2011;17(3):158-65.
2011: Soyeon Lim; Serge Przedborski; Phillip M Rappold; David Blum; Adrianne S Chesser; Jonathan C Grima; Kim Tieu
D-β-hydroxybutyrate is protective in mouse models of Huntington's disease.
PloS one 2011;6(9):e24620.
2011: Wei Zhang; Kester Phillips; Albert R Wielgus; Jie Liu; Alberto Albertini; Fabio A Zucca; Rudolph Faust; Steven Y Qian; David S Miller; Colin F Chignell; Belinda Wilson; Vernice Jackson-Lewis; Serge Przedborski; Danielle Joset; John Loike; Jau-Shyong Hong; David Sulzer; Luigi Zecca
Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease.
Neurotoxicity research 2011;19(1):63-72.
2010: Virginia Le Verche; Serge Przedborski
Is amyotrophic lateral sclerosis a mitochondrial channelopathy?
Neuron 2010;67(4):523-4.
2010: Celine Perier; Jordi Bové; Benjamin DEHAY; Vernice Jackson-Lewis; Peter S Rabinovitch; Serge Przedborski; Miquel Vila
Apoptosis-inducing factor deficiency sensitizes dopaminergic neurons to parkinsonian neurotoxins.
Annals of neurology 2010;68(2):184-92.
2010: Hynek Wichterle; Serge Przedborski
What can pluripotent stem cells teach us about neurodegenerative diseases?
Nature neuroscience 2010;13(7):800-4.
2010: Cristofol Vives-Bauza; Serge Przedborski
PINK1 points Parkin to mitochondria.
Autophagy 2010;6(5):674-5.
2010: Dimitra Papadimitriou; Virginia Le Verche; Arnaud Jacquier; Burcin Ikiz; Serge Przedborski; Diane B Re
Inflammation in ALS and SMA: sorting out the good from the evil.
Neurobiology of disease 2010;37(3):493-502.
2010: Cristofol Vives-Bauza; Rosa L A de Vries; Maja Tocilescu; Serge Przedborski
PINK1/Parkin direct mitochondria to autophagy.
Autophagy 2010;6(2):315-6.
2010: Cristina Malagelada; Zong Hao Jin; Vernice Jackson-Lewis; Serge Przedborski; Lloyd A Greene
Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(3):1166-75.
2010: Cristofol Vives-Bauza; Chun Zhou; Yong Huang; Mei Cui; Rosa L A de Vries; Jiho Kim; Jessica May; Maja Aleksandra Tocilescu; Wencheng Liu; Han Seok Ko; Jordi Magrané; Darren J Moore; Valina Dawson; Regis Grailhe; Ted M Dawson; Chenjian Li; Kim Tieu; Serge Przedborski
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(1):378-83.
2010: Cristofol Vives-Bauza; Maja Tocilescu; Rosa L A Devries; Dana M Alessi; Vernice Jackson-Lewis; Serge Przedborski
Control of mitochondrial integrity in Parkinson's disease.
Progress in brain research 2010;183():99-113.
2010: Serge Przedborski
Inflammation and Parkinson's disease pathogenesis.
Movement disorders : official journal of the Movement Disorder Society 2010;25 Suppl 1():S55-7.
2009: Cristofol Vives-Bauza; Rosa L A de Vries; Maja Aleksandra Tocilescu; Serge Przedborski
Is there a pathogenic role for mitochondria in Parkinson's disease?
Parkinsonism & related disorders 2009;15 Suppl 3():S241-4.
2009: Tuan Hoang; Dong-Kug Choi; Makiko Nagai; Du-Chu Wu; Tetsuya Nagata; Delphine Prou; Glenn L Wilson; Miquel Vila; Vernice Jackson-Lewis; Valina Dawson; Ted M Dawson; Marie-Francoise Chesselet; Serge Przedborski
Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson disease.
Free radical biology & medicine 2009;47(7):1049-56.
2009: Yanping Li; Wencheng Liu; Tinmarla F Oo; Lei Wang; Yi Tang; Vernice Jackson-Lewis; Chun Zhou; Kindiya Geghman; Mikhail Bogdanov; Serge Przedborski; M Flint Beal; Robert E Burke; Chenjian Li
Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease.
Nature neuroscience 2009;12(7):826-8.
2009: Chun Zhou; Serge Przedborski
Intrabody and Parkinson's disease.
Biochimica et biophysica acta 2009;1792(7):634-42.
2009: Mei Cui; Radha Aras; Whitney V Christian; Phillip M Rappold; Mamata Hatwar; Joseph Panza; Vernice Jackson-Lewis; Jonathan A Javitch; Nazzareno Ballatori; Serge Przedborski; Kim Tieu
The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(19):8043-8.
2008: Burcin Ikiz; Serge Przedborski
A sequel to the tale of p25/Cdk5 in neurodegeneration.
Neuron 2008;60(5):731-2.
2008: Chun Zhou; Yong Huang; Serge Przedborski
Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance.
Annals of the New York Academy of Sciences 2008;1147():93-104.
2008: Chun Zhou; Yong Huang; Yufang Shao; Jessica May; Delphine Prou; Celine Perier; William T Dauer; Eric A Schon; Serge Przedborski
The kinase domain of mitochondrial PINK1 faces the cytoplasm.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):12022-7.
2008: Marta Martinez-Vicente; Zsolt Talloczy; Susmita Kaushik; Ashish C Massey; Joseph Mazzulli; Eugene V Mosharov; Roberto Hodara; Ross Fredenburg; Du-Chu Wu; Antonia Follenzi; William T Dauer; Serge Przedborski; Harry Ischiropoulos; Peter T Lansbury; David Sulzer; Ana Maria Cuervo
Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy.
The Journal of clinical investigation 2008;118(2):777-88.
2008: Rebecca Banerjee; R Lee Mosley; Ashley D Reynolds; Alok Dhar; Vernice Jackson-Lewis; Paul H Gordon; Serge Przedborski; Howard E Gendelman
Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice.
PloS one 2008;3(7):e2740.
2008: Eric J Benner; Rebecca Banerjee; Ashley D Reynolds; Simon Sherman; Vladimir Pisarev; Vladislav Tsiperson; Craig Nemachek; Pawel Ciborowski; Serge Przedborski; R Lee Mosley; Howard E Gendelman
Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons.
PloS one 2008;3(1):e1376.
2007: Eva Andres-Mateos; Celine Perier; Li Zhang; Beatrice Blanchard-Fillion; Todd M Greco; Bobby Thomas; Han Seok Ko; Masayuki Sasaki; Harry Ischiropoulos; Serge Przedborski; Ted M Dawson; Valina Dawson
DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(37):14807-12.
2007: Serge Przedborski
Peroxiredoxin-2 links Cdk5 to neurodegeneration.
Nature medicine 2007;13(8):907-9.
2007: Celine Perier; Jordi Bové; Du-Chu Wu; Benjamin DEHAY; Dong-Kug Choi; Vernice Jackson-Lewis; Silvia Rathke-Hartlieb; Philippe Bouillet; Andreas Strasser; Jörg B Schulz; Serge Przedborski; Miquel Vila
Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(19):8161-6.
2007: Makiko Nagai; Diane B Re; Tetsuya Nagata; Alcmène Chalazonitis; Thomas M Jessell; Hynek Wichterle; Serge Przedborski
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons.
Nature neuroscience 2007;10(5):615-22.
2007: Andrew J Whittle; Owen A Ross; A Naini; P Gordon; H Mistumoto; Justus C Dächsel; Jeremy T Stone; Zbigniew K Wszolek; Matthew J Farrer; Serge Przedborski
Pathogenic Lrrk2 substitutions and Amyotrophic lateral sclerosis.
Journal of neural transmission (Vienna, Austria : 1996) 2007;114(3):327-9.
2007: Serge Przedborski
Neuroinflammation and Parkinson's disease.
Handbook of clinical neurology 2007;83():535-51.
2007: Vernice Jackson-Lewis; Serge Przedborski
Protocol for the MPTP mouse model of Parkinson's disease.
Nature protocols 2007;2(1):141-51.
2006: Eugene V Mosharov; Roland G W Staal; Jordi Bové; Delphine Prou; Anthonia Hananiya; Dmitriy Markov; Nathan Poulsen; Kristin Larsen; Candace M H Moore; Matthew D Troyer; Robert H Edwards; Serge Przedborski; David Sulzer
Alpha-synuclein overexpression increases cytosolic catecholamine concentration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(36):9304-11.
2006: Du-Chu Wu; Diane Bérangère Ré; Makiko Nagai; Harry Ischiropoulos; Serge Przedborski
The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(32):12132-7.
2006: Jordi Bové; Chun Zhou; Vernice Jackson-Lewis; Julie Taylor; Yaping Chu; Hardy J Rideout; Du-Chu Wu; Jeffrey Kordower; Leonard Petrucelli; Serge Przedborski
Proteasome inhibition and Parkinson's disease modeling.
Annals of neurology 2006;60(2):260-4.
2006: Suhayl Dhib-Jalbut; Douglas L Arnold; Don W Cleveland; Mark Fisher; Robert M Friedlander; M Maral Mouradian; Serge Przedborski; Bruce D Trapp; Tony Wyss-Coray; V Wee Yong
Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases.
Journal of neuroimmunology 2006;176(1-2):198-215.
2006: Diane Bérangère Ré; Serge Przedborski
Fractalkine: moving from chemotaxis to neuroprotection.
Nature neuroscience 2006;9(7):859-61.
2006: Béatrice Blanchard-Fillion; Delphine Prou; Manuela Polydoro; David Spielberg; Elpida Tsika; Zeneng Wang; Stanley L Hazen; Michael Koval; Serge Przedborski; Harry Ischiropoulos
Metabolism of 3-nitrotyrosine induces apoptotic death in dopaminergic cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(23):6124-30.
2006: Gabriele Almer; Hitoshi Kikuchi; Peter Teismann; Serge Przedborski
Is prostaglandin E(2) a pathogenic factor in amyotrophic lateral sclerosis?
Annals of neurology 2006;59(6):980-3.
2006: Paul H Gordon; Carolyn Doorish; Jacqueline Montes; R L Mosley; R L Mosely; B Diamond; Robert B MacArthur; Louis H Weimer; Petra Kaufmann; Arthur P Hays; Lewis P Rowland; Howard Gendelman; Serge Przedborski; Hiroshi Mitsumoto
Randomized controlled phase II trial of glatiramer acetate in ALS.
Neurology 2006;66(7):1117-9.
2006: Hitoshi Kikuchi; Gabriele Almer; Satoshi Yamashita; Christelle Guégan; Makiko Nagai; Zuoshang Xu; Alexander A Sosunov; Guy M McKhann; Serge Przedborski
Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):6025-30.
2005: Rina Ved; Shamol Saha; Beth Westlund; Celine Perier; Lucinda Burnam; Anne Sluder; Marius Hoener; Cecília M P Rodrigues; Aixa Alfonso; Clifford Steer; Leo Liu; Serge Przedborski; Benjamin Wolozin
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.
The Journal of biological chemistry 2005;280(52):42655-68.
2005: Celine Perier; Kim Tieu; Christelle Guégan; Casper Caspersen; Vernice Jackson-Lewis; Valerio Carelli; Andrea Martinuzzi; Michio Hirano; Serge Przedborski; Miquel Vila
Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(52):19126-31.
2005: Xiaohong Li; Lewis P Rowland; Hiroshi Mitsumoto; Serge Przedborski; Thomas D Bird; Gerard D Schellenberg; Elaine Peskind; Nancy Johnson; Teepu Siddique; Marek-Marsel Mesulam; Sandra Weintraub; James A Mastrianni
Prion protein codon 129 genotype prevalence is altered in primary progressive aphasia.
Annals of neurology 2005;58(6):858-64.
2005: Robert M Silva; Vincent Ries; Tinmarla Frances Oo; Olga Yarygina; Vernice Jackson-Lewis; Elizabeth J Ryu; Phoebe D Lu; Stefan Marciniak; David Ron; Serge Przedborski; Nikolai Kholodilov; Lloyd A Greene; Robert E Burke
CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism.
Journal of neurochemistry 2005;95(4):974-86.
2005: Dong-Kug Choi; Subramaniam Pennathur; Celine Perier; Kim Tieu; Peter Teismann; Du-Chu Wu; Vernice Jackson-Lewis; Miquel Vila; Jean-Paul Vonsattel; Jay W Heinecke; Serge Przedborski
Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(28):6594-600.
2005: Jordi Bové; Delphine Prou; Celine Perier; Serge Przedborski
Toxin-induced models of Parkinson's disease.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2005;2(3):484-94.
2005: Serge Przedborski
Pathogenesis of nigral cell death in Parkinson's disease.
Parkinsonism & related disorders 2005;11 Suppl 1():S3-7.
2005: Serge Przedborski; Harry Ischiropoulos
Reactive oxygen and nitrogen species: weapons of neuronal destruction in models of Parkinson's disease.
Antioxidants & redox signaling 2005;7(5-6):685-93.
2005: Jason Eriksen; Serge Przedborski; Leonard Petrucelli
Gene dosage and pathogenesis of Parkinson's disease.
Trends in molecular medicine 2005;11(3):91-6.
2004: Serge Przedborski
Molecular targets for neuroprotection.
Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 2004;5 Suppl 1():14-8.
2004: Hiroshi Mitsumoto; Paul Gordon; Petra Kaufmann; Clifton L Gooch; Serge Przedborski; Lewis P Rowland
Randomized control trials in ALS: lessons learned.
Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 2004;5 Suppl 1():8-13.
2004: Serge Przedborski; Kim Tieu; Celine Perier; Miquel Vila
MPTP as a mitochondrial neurotoxic model of Parkinson's disease.
Journal of bioenergetics and biomembranes 2004;36(4):375-9.
2004: Miquel Vila; Serge Przedborski
Genetic clues to the pathogenesis of Parkinson's disease.
Nature medicine 2004;10 Suppl():S58-62.
2004: Kim Tieu; Celine Perier; Miquel Vila; Casper Caspersen; Hui-Ping Zhang; Peter Teismann; Vernice Jackson-Lewis; David M Stern; Shi Du Yan; Serge Przedborski
L-3-hydroxyacyl-CoA dehydrogenase II protects in a model of Parkinson's disease.
Annals of neurology 2004;56(1):51-60.
2004: Eric J Benner; R Lee Mosley; Christopher J Destache; Travis B Lewis; Vernice Jackson-Lewis; Santhi Gorantla; Craig Nemachek; Steven R Green; Serge Przedborski; Howard E Gendelman
Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(25):9435-40.
2004: Shawn Hayley; Stephen J Crocker; Patrice D Smith; Tanaya Shree; Vernice Jackson-Lewis; Serge Przedborski; Matthew P Mount; Ruth Slack; Hymie Anisman; David Park
Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(8):2045-53.
2004: Stéphane Hunot; Miquel Vila; Peter Teismann; Roger J Davis; Etienne C Hirsch; Serge Przedborski; Pasko Rakic; Richard A Flavell
JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(2):665-70.
2004: Serge Przedborski
Clarification: Pathogenic role of glial cells in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2004;19(1):118.
2004: Serge Przedborski
Programmed cell death in amyotrophic lateral sclerosis: a mechanism of pathogenic and therapeutic importance.
The neurologist 2004;10(1):1-7.
2003: Erwan Bezard; Sandra Dovero; David Belin; Sophie Duconger; Vernice Jackson-Lewis; Serge Przedborski; Pier Vincenzo Piazza; Christian E Gross; Ghassan Jaber
Enriched environment confers resistance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and cocaine: involvement of dopamine transporter and trophic factors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(35):10999-1007.
2003: Yu Zhang; Victor O Ona; Mingwei Li; Martin Drozda; Michel Dubois-Dauphin; Serge Przedborski; Robert J Ferrante; Robert M Friedlander
Sequential activation of individual caspases, and of alterations in Bcl-2 proapoptotic signals in a mouse model of Huntington's disease.
Journal of neurochemistry 2003;87(5):1184-92.
2003: Patrice D Smith; Stephen J Crocker; Vernice Jackson-Lewis; Kelly L Jordan-Sciutto; Shawn Hayley; Matthew P Mount; Michael J O'Hare; Steven M Callaghan; ruth slack; Serge Przedborski; Hymie Anisman; David Park
Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(23):13650-5.
2003: William T Dauer; Serge Przedborski
Parkinson's disease: mechanisms and models.
Neuron 2003;39(6):889-909.
2003: Kim Tieu; Celine Perier; Casper Caspersen; Peter Teismann; Du-Chu Wu; Shi Du Yan; Ali Naini; Miquel Vila; Vernice Jackson-Lewis; Ravichandran Ramasamy; Serge Przedborski
D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease.
The Journal of clinical investigation 2003;112(6):892-901.
2003: Celine Perier; Jordi Bové; Miquel Vila; Serge Przedborski
The rotenone model of Parkinson's disease.
Trends in neurosciences 2003;26(7):345-6.
2003: Kim Tieu; Harry Ischiropoulos; Serge Przedborski
Nitric oxide and reactive oxygen species in Parkinson's disease.
IUBMB life 2003;55(6):329-35.
2003: Peter Teismann; Miquel Vila; Dong-Kug Choi; Kim Tieu; Du-Chu Wu; Vernice Jackson-Lewis; Serge Przedborski
COX-2 and neurodegeneration in Parkinson's disease.
Annals of the New York Academy of Sciences 2003;991():272-7.
2003: Serge Przedborski; Miquel Vila
The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's disease.
Annals of the New York Academy of Sciences 2003;991():189-98.
2003: Stephen J Crocker; Patrice D Smith; Vernice Jackson-Lewis; Wiplove R Lamba; Shawn Hayley; Erich Grimm; Steven M Callaghan; ruth slack; Edon Melloni; Serge Przedborski; George S Robertson; Hymie Anisman; Zul Merali; David Park
Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(10):4081-91.
2003: Du-Chu Wu; Peter Teismann; Kim Tieu; Miquel Vila; Vernice Jackson-Lewis; Harry Ischiropoulos; Serge Przedborski
NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):6145-50.
2003: Miquel Vila; Serge Przedborski
Targeting programmed cell death in neurodegenerative diseases.
Nature reviews. Neuroscience 2003;4(5):365-75.
2003: Peter Teismann; Kim Tieu; Dong-Kug Choi; Du-Chu Wu; Ali Naini; Stéphane Hunot; Miquel Vila; Vernice Jackson-Lewis; Serge Przedborski
Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5473-8.
2003: Peter Teismann; Kim Tieu; Oren Cohen; Dong-Kug Choi; Du-Chu Wu; Daniel Marks; Miquel Vila; Vernice Jackson-Lewis; Serge Przedborski
Pathogenic role of glial cells in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2003;18(2):121-9.
2003: Christelle Guégan; Serge Przedborski
Programmed cell death in amyotrophic lateral sclerosis.
The Journal of clinical investigation 2003;111(2):153-61.
2003: Serge Przedborski; Miquel Vila; Vernice Jackson-Lewis
Neurodegeneration: what is it and where are we?
The Journal of clinical investigation 2003;111(1):3-10.
2003: Serge Przedborski; Hiroshi Mitsumoto; Lewis P Rowland
Recent advances in amyotrophic lateral sclerosis research.
Current neurology and neuroscience reports 2003;3(1):70-7.
2003: Serge Przedborski; Vernice Jackson-Lewis; Miquel Vila; Du-Chu Wu; Peter Teismann; Kim Tieu; Dong-Kug Choi; Oren Cohen
Free radical and nitric oxide toxicity in Parkinson's disease.
Advances in neurology 2003;91():83-94.
2002: Du-Chu Wu; Kim Tieu; Oren Cohen; Dong-Kug Choi; Miquel Vila; Vernice Jackson-Lewis; Peter Teismann; Serge Przedborski
Glial cell response: A pathogenic factor in Parkinson's disease.
Journal of neurovirology 2002;8(6):551-8.
2002: Daniel B Drachman; Krystl Frank; Margaret Dykes-Hoberg; Peter Teismann; Gabriele Almer; Serge Przedborski; Jeffrey rothstein
Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS.
Annals of neurology 2002;52(6):771-8.
2002: William T Dauer; Nikolai Kholodilov; Miquel Vila; Anne-Cecile Trillat; Rose E Goodchild; Kristin Larsen; Roland G W Staal; Kim Tieu; Yvonne Schmitz; Chao Annie Yuan; Marcelo Rocha; Vernice Jackson-Lewis; Steven M Hersch; David Sulzer; Serge Przedborski; Robert Burke; René Hen
Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14524-9.
2002: Christelle Guégan; Miquel Vila; Peter Teismann; Caiping Chen; Brigitte Onténiente; Mingwei Li; Robert M Friedlander; Serge Przedborski; Peter Teissman
Instrumental activation of bid by caspase-1 in a transgenic mouse model of ALS.
Molecular and cellular neurosciences 2002;20(4):553-62.
2002: Shan Zhu; Irina G Stavrovskaya; Martin Drozda; Betty Y S Kim; Victor O Ona; Mingwei Li; Satinder Sarang; Allen S Liu; Dean Hartley; Du-Chu Wu; Steven Gullans; Robert J Ferrante; Serge Przedborski; Bruce Kristal; Robert M Friedlander
Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice.
Nature 2002;417(6884):74-8.
2002: Gabriele Almer; Peter Teismann; Z Stevic; J Halaschek-Wiener; L Deecke; V Kostic; Serge Przedborski
Increased levels of the pro-inflammatory prostaglandin PGE2 in CSF from ALS patients.
Neurology 2002;58(8):1277-9.
2002: Du-Chu Wu; Vernice Jackson-Lewis; Miquel Vila; Kim Tieu; Peter Teismann; Caryn Vadseth; Dong-Kug Choi; Harry Ischiropoulos; Serge Przedborski
Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(5):1763-71.
2002: Serge Przedborski; Vernice Jackson-Lewis; David Sulzer; Ali Naini; Norma Romero; Caiping Chen; Julia Arias
Transgenic superoxide dismutase overproducer: murine.
Methods in enzymology 2002;349():180-90.
2002: V S Kostić; J Marinković; Marina Svetel; Elka Stefanova; Serge Przedborski
The effect of stage of Parkinson's disease at the onset of levodopa therapy on development of motor complications.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2002;9(1):9-14.
2001: Andrew Feigin; M Fukuda; Vijay Dhawan; Serge Przedborski; Vernice Jackson-Lewis; Marc J Mentis; James R Moeller; David Eidelberg
Metabolic correlates of levodopa response in Parkinson's disease.
Neurology 2001;57(11):2083-8.
2001: Béatrice Blanchard-Fillion; José M Souza; T Friel; G C Jiang; Kent Vrana; V Sharov; L Barrón; C Schöneich; Celia Quijano; Beatriz Alvarez; Rafael Radi; Serge Przedborski; G S Fernando; J Horwitz; Harry Ischiropoulos
Nitration and inactivation of tyrosine hydroxylase by peroxynitrite.
The Journal of biological chemistry 2001;276(49):46017-23.
2001: Miquel Vila; D C Wu; Serge Przedborski
Engineered modeling and the secrets of Parkinson's disease.
Trends in neurosciences 2001;24(11 Suppl):S49-55.
2001: Asa Petersén; Oskar Hansson; Zoe Puschban; Ellen Sapp; N Romero; Roger F Castilho; David Sulzer; M Rice; Marian DiFiglia; Serge Przedborski; Patrik Brundin
Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine.
The European journal of neuroscience 2001;14(9):1425-35.
2001: A Petersén A; Kristin Larsen; GG Behr; N Romero; Serge Przedborski; Patrik Brundin; David Sulzer
Brain-derived neurotrophic factor inhibits apoptosis and dopamine-induced free radical production in striatal neurons but does not prevent cell death.
Brain research bulletin 2001;56(3-4):331-5.
2001: Christelle Guégan; Miquel Vila; Gorazd Rosoklija; Arthur P Hays; Serge Przedborski
Recruitment of the mitochondrial-dependent apoptotic pathway in amyotrophic lateral sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(17):6569-76.
2001: Miquel Vila; Vernice Jackson-Lewis; Christelle Guégan; Du-Chu Wu; Peter Teismann; Dong-Kug Choi; Kim Tieu; Serge Przedborski
The role of glial cells in Parkinson's disease.
Current opinion in neurology 2001;14(4):483-9.
2001: Nir Giladi; M P McDermott; Stanley Fahn; Serge Przedborski; Joseph Jankovic; Matthew B Stern; Caroline M Tanner
Freezing of gait in PD: prospective assessment in the DATATOP cohort.
Neurology 2001;56(12):1712-21.
2001: Yasuji Matsuoka; Miquel Vila; Sarah J Lincoln; Alison L McCormack; M Picciano; John LaFrancois; X Yu; dennis dickson; William J Langston; E McGowan; Matthew J Farrer; John Hardy; karen duff; Serge Przedborski; Donato A Di Monte
Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter.
Neurobiology of disease 2001;8(3):535-9.
2001: Kristin Larsen; GG Behr; N Romero; Serge Przedborski; Patrik Brundin; David Sulzer
Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration.
Human molecular genetics 2001;10(12):1243-54.
2001: Serge Przedborski; Vernice Jackson-Lewis; Ali Naini; Michael W Jakowec; Giselle M Petzinger; R Miller; M Akram
The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety.
Journal of neurochemistry 2001;76(5):1265-74.
2001: Miquel Vila; Vernice Jackson-Lewis; S Vukosavic; Ruth Djaldetti; GT Liberatore; Daniel Offen; S J Korsmeyer; Serge Przedborski
Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2837-42.
2001: Gabriele Almer; Christelle Guégan; Peter Teismann; Ali Naini; Gorazd Rosoklija; Arthur P Hays; C Chen; Serge Przedborski
Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis.
Annals of neurology 2001;49(2):176-85.
2001: Serge Przedborski; Ted M Dawson
The role of nitric oxide in Parkinson's disease.
Methods in molecular medicine 2001;62():113-36.
2001: Serge Przedborski; Miquel Vila
The last decade in Parkinson's disease research. Basic sciences.
Advances in neurology 2001;86():177-86.
2001: Serge Przedborski; Q Chen; Miquel Vila; Benoit I Giasson; R Djaldatti; S Vukosavic; José M Souza; Vernice Jackson-Lewis; Virginia M-Y Lee; Harry Ischiropoulos
Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease.
Journal of neurochemistry 2001;76(2):637-40.
2000: S Vukosavic; Leonidas Stefanis; Vernice Jackson-Lewis; Christelle Guégan; N Romero; Caiping Chen; Michel Dubois-Dauphin; Serge Przedborski
Delaying caspase activation by Bcl-2: A clue to disease retardation in a transgenic mouse model of amyotrophic lateral sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(24):9119-25.
2000: Dominic Thyagarajan; Susan Bressman; C Bruno; Serge Przedborski; S Shanske; T Lynch; Stanley Fahn; S DiMauro
A novel mitochondrial 12SrRNA point mutation in parkinsonism, deafness, and neuropathy.
Annals of neurology 2000;48(5):730-6.
2000: Vernice Jackson-Lewis; Miquel Vila; Ruth Djaldetti; C Guegan; GT Liberatore; J Liu; Karen L O'Malley; Robert E Burke; Serge Przedborski
Developmental cell death in dopaminergic neurons of the substantia nigra of mice.
The Journal of comparative neurology 2000;424(3):476-88.
2000: Mingwei Li; Victor O Ona; Christelle Guégan; M Chen; Vernice Jackson-Lewis; LJ Andrews; A J Olszewski; Philip E Stieg; J P Lee; Serge Przedborski; Robert M Friedlander
Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model.
Science (New York, N.Y.) 2000;288(5464):335-9.
2000: Miquel Vila; S Vukosavic; Vernice Jackson-Lewis; Michael Neystat; Michael W Jakowec; Serge Przedborski
Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP.
Journal of neurochemistry 2000;74(2):721-9.
1999: Subramaniam Pennathur; Vernice Jackson-Lewis; Serge Przedborski; Jay W Heinecke
Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease.
The Journal of biological chemistry 1999;274(49):34621-8.
1999: S Vukosavic; Michel Dubois-Dauphin; N Romero; Serge Przedborski
Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis.
Journal of neurochemistry 1999;73(6):2460-8.
1999: GT Liberatore; Vernice Jackson-Lewis; S Vukosavic; Allen S Mandir; Miquel Vila; W G McAuliffe; Valina Dawson; Ted M Dawson; Serge Przedborski
Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease.
Nature medicine 1999;5(12):1403-9.
1999: David M Donovan; LL Miner; M P Perry; RS Revay; Lawrence G Sharpe; Serge Przedborski; V Kostic; Rex Philpot; Cheryl L Kirstein; Richard B Rothman; Charles W Schindler; George R. Uhl
Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression.
Brain research. Molecular brain research 1999;73(1-2):37-49.
1999: Gabriele Almer; Gorazd Rosoklija; M Hirano; Arthur P Hays; Serge Przedborski
Does increased superoxide dismutase activity really cause muscular dystrophy?
Annals of neurology 1999;46(1):135.
1999: Vladimir S Kostic; Marina Svetel; Nadezda Sternic; Natasa Dragasevic; Serge Przedborski
Theophylline increases "on" time in advanced parkinsonian patients.
Neurology 1999;52(9):1916.
1999: Gabriele Almer; S Vukosavic; N Romero; Serge Przedborski
Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis.
Journal of neurochemistry 1999;72(6):2415-25.
1999: Allen S Mandir; Serge Przedborski; Vernice Jackson-Lewis; ZQ Wang; Cynthia M Simbulan-Rosenthal; Mark E Smulson; B E Hoffman; DB Guastella; Valina Dawson; Ted M Dawson
Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5774-9.
1999: Michael Neystat; T Lynch; Serge Przedborski; Nikolai Kholodilov; Margarita Rzhetskaya; Robert E Burke
Alpha-synuclein expression in substantia nigra and cortex in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 1999;14(3):417-22.
1998: Esta Sterneck; Richard Paylor; Vernice Jackson-Lewis; M Libbey; Serge Przedborski; L Tessarollo; Jacqueline N Crawley; Peter F Johnson
Selectively enhanced contextual fear conditioning in mice lacking the transcriptional regulator CCAAT/enhancer binding protein delta.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10908-13.
1998: Serge Przedborski; Vernice Jackson-Lewis
Experimental developments in movement disorders: update on proposed free radical mechanisms.
Current opinion in neurology 1998;11(4):335-9.
1998: Emmanuel N Pothos; Serge Przedborski; Viviana Davila; Yvonne Schmitz; David Sulzer
D2-Like dopamine autoreceptor activation reduces quantal size in PC12 cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(15):5575-85.
1998: K Kompoliti; Christopher G Goetz; Bradley Boeve; Demetrius M Maraganore; J Eric Ahlskog; CD Marsden; K P Bhatia; P E Greene; Serge Przedborski; E C Seal; R S Burns; Robert A Hauser; LL Gauger; Stewart A Factor; Eric S Molho; D E Riley
Clinical presentation and pharmacological therapy in corticobasal degeneration.
Archives of neurology 1998;55(7):957-61.
1998: J Ara; Serge Przedborski; Ali Naini; Vernice Jackson-Lewis; R R Trifiletti; J Horwitz; H Ischiropoulos
Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7659-63.
1998: Serge Przedborski; E A Schon
Loss of ROS--a radical response.
Nature genetics 1998;18(2):99-100.
1998: Serge Przedborski; Vernice Jackson-Lewis
Mechanisms of MPTP toxicity.
Movement disorders : official journal of the Movement Disorder Society 1998;13 Suppl 1():35-8.
1998: Michael W Jakowec; Vernice Jackson-Lewis; X Chen; J William Langston; Serge Przedborski
The postnatal development of AMPA receptor subunits in the basal ganglia of the rat.
Developmental neuroscience 1998;20(1):19-33.
1998: M Levivier; Serge Przedborski
Quinolinic acid-induced lesions of the rat striatum: quantitative autoradiographic binding assessment.
Neurological research 1998;20(1):46-56.
1997: N Takahashi; LL Miner; Ichiro Sora; H Ujike; RS Revay; V Kostic; Vernice Jackson-Lewis; Serge Przedborski; George R. Uhl
VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(18):9938-43.
1997: V Kostic; Vernice Jackson-Lewis; Fabienne de Bilbao; Michel Dubois-Dauphin; Serge Przedborski
Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis.
Science (New York, N.Y.) 1997;277(5325):559-62.
1997: MA Mena; U Khan; D M Togasaki; David Sulzer; C J Epstein; Serge Przedborski
Effects of wild-type and mutated copper/zinc superoxide dismutase on neuronal survival and L-DOPA-induced toxicity in postnatal midbrain culture.
Journal of neurochemistry 1997;69(1):21-33.
1997: V Kostic; ME Gurney; H X Deng; Teepu Siddique; C J Epstein; Serge Przedborski
Midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis.
Annals of neurology 1997;41(4):497-504.
1996: Serge Przedborski; Vijay Dhawan; D M Donaldson; Peregrine L Murphy; D McKenna-Yasek; F S Mandel; R H Brown; David Eidelberg
Nigrostriatal dopaminergic function in familial amyotrophic lateral sclerosis patients with and without copper/zinc superoxide dismutase mutations.
Neurology 1996;47(6):1546-51.
1996: Serge Przedborski; V N Kostic; R E Burke
Delayed-onset dyskinesias.
Neurology 1996;47(5):1358-9.
1996: Serge Przedborski; U Khan; V Kostic; E Carlson; C J Epstein; David Sulzer
Increased superoxide dismutase activity improves survival of cultured postnatal midbrain neurons.
Journal of neurochemistry 1996;67(4):1383-92.
1996: Serge Przedborski; Vernice Jackson-Lewis; R Yokoyama; T Shibata; Valina Dawson; Ted M Dawson
Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):4565-71.
1996: S Dethy; Marie-Aline Laute; D M Togasaki; Serge Przedborski; Philippe Damhaut; Philippe Thiry; J Hildebrand; Serge Goldman
Systemic and intrastriatal theophylline have opposite effects on dopamine and dopamine metabolites measured by intrastriatal microdialysis in the rat.
Neuroscience letters 1996;208(3):159-62.
1996: Serge Przedborski; D M Donaldson; Peregrine L Murphy; O Hirsch; D Lange; Ali Naini; D McKenna-Yasek; R H Brown
Blood superoxide dismutase, catalase and glutathione peroxidase activities in familial and sporadic amyotrophic lateral sclerosis.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(1):57-64.
1996: Serge Przedborski; D Donaldson; M Jakowec; Stephen J Kish; M Guttman; Gorazd Rosoklija; Arthur P Hays
Brain superoxide dismutase, catalase, and glutathione peroxidase activities in amyotrophic lateral sclerosis.
Annals of neurology 1996;39(2):158-65.
1996: C Raftopoulos; S Dethy; Marie-Aline Laute; Serge Goldman; Ali Naini; Serge Przedborski; J Hildebrand
Slow increase of homovanillic acid in cerebrospinal fluid after levodopa administration.
Movement disorders : official journal of the Movement Disorder Society 1996;11(1):59-62.
1995: Marc Levivier; Serge Przedborski; C Bencsics; Un Jung Kang
Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(12):7810-20.
1995: David Eidelberg; James R Moeller; T Ishikawa; Vijay Dhawan; Phoebe Spetsieris; Serge Przedborski; Stanley Fahn
The metabolic topography of idiopathic torsion dystonia.
Brain : a journal of neurology 1995;118 ( Pt 6)():1473-84.
1995: Marc Levivier; D M Gash; Serge Przedborski
Time course of the neuroprotective effect of transplantation on quinolinic acid-induced lesions of the striatum.
Neuroscience 1995;69(1):43-50.
1995: B Parsons; D M Togasaki; S Kassir; Serge Przedborski
Neuroleptics up-regulate adenosine A2a receptors in rat striatum: implications for the mechanism and the treatment of tardive dyskinesia.
Journal of neurochemistry 1995;65(5):2057-64.
1995: David Eidelberg; James R Moeller; T Ishikawa; Vijay Dhawan; Phoebe Spetsieris; Thomas Chaly; A Belakhlef; F Mandel; Serge Przedborski; Stanley Fahn
Early differential diagnosis of Parkinson's disease with 18F-fluorodeoxyglucose and positron emission tomography.
Neurology 1995;45(11):1995-2004.
1995: Vernice Jackson-Lewis; M Jakowec; Robert E Burke; Serge Przedborski
Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1995;4(3):257-69.
1995: G Petzinger; STEPHAN MAYER; Serge Przedborski
Fentanyl-induced dyskinesias.
Movement disorders : official journal of the Movement Disorder Society 1995;10(5):679-80.
1995: Serge Przedborski; Marc Levivier; H Jiang; M Ferreira; Vernice Jackson-Lewis; D Donaldson; D M Togasaki
Dose-dependent lesions of the dopaminergic nigrostriatal pathway induced by intrastriatal injection of 6-hydroxydopamine.
Neuroscience 1995;67(3):631-47.
1995: Serge Przedborski; Vernice Jackson-Lewis; Stanley Fahn
Antiparkinsonian therapies and brain mitochondrial complex I activity.
Movement disorders : official journal of the Movement Disorder Society 1995;10(3):312-7.
1995: Serge Przedborski; Marc Levivier; C Raftopoulos; Ali Naini; J Hildebrand
Peripheral and central pharmacokinetics of apomorphine and its effect on dopamine metabolism in humans.
Movement disorders : official journal of the Movement Disorder Society 1995;10(1):28-36.
1994: David Eidelberg; James R Moeller; Vijay Dhawan; Phoebe Spetsieris; S Takikawa; T Ishikawa; Thomas Chaly; W Robeson; D Margouleff; Serge Przedborski
The metabolic topography of parkinsonism.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1994;14(5):783-801.
1994: Serge Przedborski; Nir Giladi; S Takikawa; T Ishikawa; Vijay Dhawan; Phoebe Spetsieris; Thomas Chaly; Stanley Fahn; David Eidelberg
Metabolic topography of the hemiparkinsonism-hemiatrophy syndrome.
Neurology 1994;44(9):1622-8.
1994: Marc Levivier; S Holemans; D M Togasaki; Jean-Marie Maloteaux; Jacques Brotchi; Serge Przedborski
Quantitative assessment of quinolinic acid-induced striatal toxicity in rats using radioligand binding assays.
Neurological research 1994;16(3):194-200.
1994: U Muthane; K A Ramsay; H Jiang; Vernice Jackson-Lewis; D Donaldson; S Fernando; M Ferreira; Serge Przedborski
Differences in nigral neuron number and sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57/bl and CD-1 mice.
Experimental neurology 1994;126(2):195-204.
1994: Vernice Jackson-Lewis; Serge Przedborski
Neuroleptic medications inhibit complex I of the electron transport chain.
Annals of neurology 1994;35(2):244-5.
1993: Leonidas Stefanis; Serge Przedborski
Isolated palsy of the superior branch of the oculomotor nerve due to chronic erosive sphenoid sinusitis.
Journal of clinical neuro-ophthalmology 1993;13(4):229-31.
1993: Serge Przedborski; Vernice Jackson-Lewis; U Muthane; H Jiang; M Ferreira; Ali Naini; Stanley Fahn
Chronic levodopa administration alters cerebral mitochondrial respiratory chain activity.
Annals of neurology 1993;34(5):715-23.
1993: M Levivier; Serge Przedborski; D M Gash
Neuronal protection against excitotoxicity.
Journal of neurosurgery 1993;79(4):638-41.
1993: Nir Giladi; M Sutton; B Lo; Serge Przedborski; Stanley Fahn; J L Cadet
Toxicity of the specific antimuscarinic agent methoctramine and other non-specific anticholinergic drugs in human neuroblastoma cell lines in vitro.
Toxicology in vitro : an international journal published in association with BIBRA 1993;7(5):595-603.
1993: Serge Goldman; A Laird; J Flament-Durand; André Luxen; L M Bidaut; E Stanus; J Hildebrand; Serge Przedborski
Positron emission tomography and histopathology in Creutzfeldt-Jakob disease.
Neurology 1993;43(9):1828-30.
1993: Serge Przedborski; Serge Goldman; Marc Levivier; Nir Giladi; L M Bidaut; J Hildebrand; E Stanus; Daniel Labar; André Luxen
Brain glucose metabolism and dopamine D2 receptor analysis in a patient with hemiparkinsonism-hemiatrophy syndrome.
Movement disorders : official journal of the Movement Disorder Society 1993;8(3):391-5.
1993: H Jiang; Vernice Jackson-Lewis; U Muthane; A Dollison; M Ferreira; A Espinosa; B Parsons; Serge Przedborski
Adenosine receptor antagonists potentiate dopamine receptor agonist-induced rotational behavior in 6-hydroxydopamine-lesioned rats.
Brain research 1993;613(2):347-51.
1993: Serge Przedborski; Vernice Jackson-Lewis; U Muthane
Alpha-tocopherol levels in parkinsonian brains.
Annals of neurology 1993;33(5):560-1.
1993: Serge Przedborski; S Goldman; Nir Giladi; Vijay Dhawan; S Takikawa; J Hildebrand; Stanley Fahn; David Eidelberg
Positron emission tomography in hemiparkinsonism-hemiatrophy syndrome.
Advances in neurology 1993;60():501-5.
1992: Serge Przedborski; Marc Levivier
[Current therapeutic approach in Parkinson disease].
Revue médicale de Bruxelles 1992;13(10):360-6.
1992: Marc Levivier; Serge Goldman; L M Bidaut; André Luxen; E Stanus; Serge Przedborski; Danielle Balériaux; J Hildebrand; Jacques Brotchi
Positron emission tomography-guided stereotactic brain biopsy.
Neurosurgery 1992;31(4):792-7; discussion 797.
1992: J Hildebrand; Z Moussa; C Raftopoulos; J Vanhouche; Marie-Aline Laute; Serge Przedborski
Variations of homovanillic acid levels in ventricular cerebrospinal fluid.
Acta neurologica Scandinavica 1992;85(5):340-2.
1992: M Levivier; Serge Przedborski
Development of human neural transplantation.
Neurosurgery 1992;30(5):811-2.
1992: Serge Przedborski; V Kostic; Vernice Jackson-Lewis; Ali Naini; S Simonetti; Stanley Fahn; E Carlson; C J Epstein; J L Cadet
Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1992;12(5):1658-67.
1992: Serge Przedborski; Vernice Jackson-Lewis; V Kostic; E Carlson; C J Epstein; J L Cadet
Superoxide dismutase, catalase, and glutathione peroxidase activities in copper/zinc-superoxide dismutase transgenic mice.
Journal of neurochemistry 1992;58(5):1760-7.
1992: Nir Giladi; Don McMahon; Serge Przedborski; E Flaster; S Guillory; V Kostic; Stanley Fahn
Motor blocks in Parkinson's disease.
Neurology 1992;42(2):333-9.
1992: Serge Przedborski; A Liard; J Hildebrand
Induction of mania by apomorphine in a depressed parkinsonian patient.
Movement disorders : official journal of the Movement Disorder Society 1992;7(3):285-7.
1992: Z Moussa; C Raftopoulos; Serge Przedborski; J Hildebrand
Lack of changes in ventricular cerebrospinal fluid concentrations of homovanillic acid following acute challenge with levodopa.
Annals of neurology 1992;31(1):113-5.
1991: V Kostic; Serge Przedborski; Vernice Jackson-Lewis; J L Cadet; Robert E Burke
Effect of unilateral perinatal hypoxic-ischemic brain injury in the rat on striatal muscarinic cholinergic receptors and high-affinity choline uptake sites: a quantitative autoradiographic study.
Journal of neurochemistry 1991;57(6):1962-70.
1991: Serge Przedborski; V Kostic; Vernice Jackson-Lewis; J L Cadet; Robert E Burke
Effect of unilateral perinatal hypoxic-ischemic brain injury in the rat on dopamine D1 and D2 receptors and uptake sites: a quantitative autoradiographic study.
Journal of neurochemistry 1991;57(6):1951-61.
1991: J L Cadet; K Kujirai; Serge Przedborski
Bilateral modulation of [3H]neurotensin binding by unilateral intrastriatal 6-hydroxydopamine injections: evidence from a receptor autoradiographic study.
Brain research 1991;564(1):37-44.
1991: Serge Przedborski; M Levivier; J L Cadet
Neurotensin receptors in human meningiomas.
Annals of neurology 1991;30(5):650-4.
1991: V S Kostic; Serge Przedborski; Vernice Jackson-Lewis; J L Cadet; Robert E Burke
Effect of unilateral perinatal hypoxic-ischemic brain injury on striatal dopamine uptake sites and D1 and D2 receptors in adult rats.
Neuroscience letters 1991;129(2):197-200.
1991: Serge Przedborski; Marc Levivier; V Kostic; Vernice Jackson-Lewis; A Dollison; D M Gash; Stanley Fahn; J L Cadet
Sham transplantation protects against 6-hydroxydopamine-induced dopaminergic toxicity in rats: behavioral and morphological evidence.
Brain research 1991;550(2):231-8.
1991: Serge Przedborski; V Kostic; Vernice Jackson-Lewis; E Carlson; C J Epstein; J L Cadet
Quantitative autoradiographic distribution of [3H]-MPTP binding in the brains of superoxide dismutase transgenic mice.
Brain research bulletin 1991;26(6):987-91.
1991: J L Cadet; R Last; V Kostic; Serge Przedborski; Vernice Jackson-Lewis
Long-term behavioral and biochemical effects of 6-hydroxydopamine injections in rat caudate-putamen.
Brain research bulletin 1991;26(5):707-13.
1991: V Kostic; Serge Przedborski; E Flaster; Nadezda Sternic
Early development of levodopa-induced dyskinesias and response fluctuations in young-onset Parkinson's disease.
Neurology 1991;41(2 ( Pt 1)):202-5.
1991: K Berger; Serge Przedborski; J L Cadet
Retrograde degeneration of nigrostriatal neurons induced by intrastriatal 6-hydroxydopamine injection in rats.
Brain research bulletin 1991;26(2):301-7.
1991: Vernice Jackson-Lewis; Serge Przedborski; V Kostic; F Suber; Stanley Fahn; J L Cadet
Partial attenuation of chronic fluphenazine-induced changes in regional monoamine metabolism by D-alpha-tocopherol in rat brain.
Brain research bulletin 1991;26(2):251-8.
1991: V S Kostic; V Susic; Serge Przedborski; Nadezda Sternic
Sleep EEG in depressed and nondepressed patients with Parkinson's disease.
The Journal of neuropsychiatry and clinical neurosciences 1991;3(2):176-9.
1991: Serge Przedborski; Vernice Jackson-Lewis; Sulli Popilskis; V Kostic; Marc Levivier; Stanley Fahn; J L Cadet
Unilateral MPTP-induced parkinsonism in monkeys. A quantitative autoradiographic study of dopamine D1 and D2 receptors and re-uptake sites.
Neuro-Chirurgie 1991;37(6):377-82.
1990: Nir Giladi; Robert E Burke; V Kostic; Serge Przedborski; M Gordon; A Hunt; Stanley Fahn
Hemiparkinsonism-hemiatrophy syndrome: clinical and neuroradiologic features.
Neurology 1990;40(11):1731-4.
1990: K Kujirai; Serge Przedborski; V Kostic; Vernice Jackson-Lewis; Stanley Fahn; J L Cadet
Autoradiography of dopamine receptors and dopamine uptake sites in the spontaneously hypertensive rat.
Brain research bulletin 1990;25(5):703-9.
1990: P Mailleux; Serge Przedborski; A Beaumont; M Verslijpe; M Depierreux; M Levivier; P Kitabgi; B P Roques; JJ Vanderhaeghen
Neurotensin high affinity binding sites and endopeptidase 24.11 are present respectively in the meningothelial and in the fibroblastic components of human meningiomas.
Peptides 1990;11(6):1245-53.
1990: Serge Przedborski; M Wright; Stanley Fahn; J L Cadet
Quantitative autoradiographic changes in 5-[3H]HT-labeled 5-HT1 serotonin receptors in discrete regions of brain in the rat model of persistent dyskinesias induced by iminodipropionitrile (IDPN).
Neuroscience letters 1990;116(1-2):51-7.
1990: J L Cadet; Serge Przedborski; V Kostic; Vernice Jackson-Lewis; E Carlson; C J Epstein
Quantitative autoradiographic distribution of [3H]mazindol-labeled dopamine uptake sites in the brains of superoxide dismutase transgenic mice.
Brain research bulletin 1990;25(1):187-92.
1990: J Hildebrand; F Bourgeois; Marc Buyse; Serge Przedborski; S Goldman
Reproducibility of monoamine metabolite measurements in human cerebrospinal fluid.
Acta neurologica Scandinavica 1990;81(5):427-30.
1990: Serge Przedborski; A Ferster; S Goldman; R Wolter; M Song; T Tonnesen; Rodney J Pollitt; E Vamos
Trichothiodystrophy, mental retardation, short stature, ataxia, and gonadal dysfunction in three Moroccan siblings.
American journal of medical genetics 1990;35(4):566-73.
1989: Serge Przedborski; M Wright; Stanley Fahn; J L Cadet
Regional changes in brain 5-HT1A serotonin receptors in the rat model of persistent spasmodic dyskinesias induced by iminodipropionitrile.
Brain research 1989;504(2):311-4.
1989: Serge Przedborski; M Wright; Stanley Fahn; J L Cadet
Autoradiographic evidence of [3H]neurotensin binding changes in discrete regions of brain in the rat model of persistent spasmodic dyskinesia induced by iminodipropionitrile.
Neuroscience letters 1989;107(1-3):335-40.
1989: Robert Amson; F Sigaux; Serge Przedborski; G Flandrin; David Givol; Adam Telerman
The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(22):8857-61.
1989: guy decaux; Serge Przedborski; A Soupart
Lack of efficacy of phenytoin in the syndrome of inappropriate anti-diuretic hormone secretion of neurological origin.
Postgraduate medical journal 1989;65(765):456-8.
1989: Serge N Schiffmann; P Mailleux; Serge Przedborski; P Halleux; F Lotstra; JJ Vanderhaeghen
Cholecystokinin distribution in the human striatum and related subcortical structures.
Neurochemistry international 1989;14(2):167-73.
1989: M H De Laet; M Dassonville; H Steyaert; E Vanderveken; F Lotstra; G Vierendeels; Serge Przedborski; H Vaudry; JJ Vanderhaeghen
Decrease of vasoactive intestinal peptide, methionine-enkephalin, substance P and increase of neuropeptide Y immunoreactive nerve fibres in aganglionic colon of Hirschsprung's disease.
Neurochemistry international 1989;14(2):135-41.
1989: G Rodesch; Paul M Parizel; Claire M Farber; B Lalmand; Serge Przedborski; J D'Haens; M van Calck; A Vanderhofstadt; H Taelman; D Baleriaux
Nervous system manifestations and neuroradiologic findings in acquired immunodeficiency syndrome (AIDS).
Neuroradiology 1989;31(1):33-9.
1989: Serge Przedborski; S N Schiffmann; G Monseu; J M Maloteaux; J Flament-Durand
A case of late onset striatonigral degeneration.
Acta neurologica Belgica 1989;89(1):29-37.
1988: Serge Przedborski; E Brunko; M Hubert; Nicolas Mavroudakis; D Z de Beyl
The effect of acute hemiplegia on intercostal muscle activity.
Neurology 1988;38(12):1882-4.
1988: P Georges; Serge Przedborski; J Brotchi; M Chatel; D Gédouin; J Hildebrand
Effect of HECNU in malignant supratentorial gliomas--a phase II study.
Journal of neuro-oncology 1988;6(3):211-9.
1988: J M Gérard; J Hildebrand; Nicolas Mavroudakis; G Monseu; Serge Przedborski; P Seeldrayers; J Wautier; Diederik Zegers de Beyl
[Pathogenesis and treatment of multiple sclerosis. Review and personal results].
Revue médicale de Bruxelles 1988;9(6):334-9.
1988: Serge Przedborski; C Liesnard; P Voordecker; J M Gerard; H Taelman; S Sprecher; M Goldman; J Hildebrand
Inflammatory demyelinating polyradiculoneuropathy associated with human immunodeficiency virus infection.
Journal of neurology 1988;235(6):359-61.
1988: Serge Przedborski; S Goldman; Serge N Schiffmann; G Vierendeels; M Depierreux; M Levivier; J Hildebrand; J J Vanderhaeghen
Neuropeptide Y, somatostatin, and cholecystokinin neurone preservation in anaplastic astrocytomas.
Acta neuropathologica 1988;76(5):507-10.
1984: M Deschodt-Lanckman; D Koulischer; Serge Przedborski; M Lauwereys
Cholecystokinin octa- and tetrapeptide degradation by synaptic membranes. III. Inactivation of CCK-8 by a phosphoramidon-sensitive endopeptidase.
Peptides 1984;5(3):649-51.