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david cole

Research Profile

Chemicals & Drugs

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Julia Ekeruche-Makinde; Sian Llewellyn-Lacey; John J Miles; Kim M Miles; Mark Peakman; Johanne M Pentier; David A Price; Pierre J Rizkallah; Jamie Rossjohn; Andrea J A Schauenburg; Andrew K Sewell; Ania Skowera; Mai Ping Tan; Andrew Trimby; Hugo A van den Berg; Tamsin Williams; Mick Bailey; Anna M Bulek; Scott R Burrows; Mathew Clement; david cole; Garry Dolton; Linda Wooldridge
Peptide length determines the outcome of TCR/peptide-MHCI engagement.
Robin R Knight; Deborah Kronenberg; Mark Peakman; Andrew K Sewell; Anna Bulek; david cole; Martin Eichmann; Guo Cai Huang; Linda Wooldridge; Min Zhao; Ania Skowera
Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity.
Julia Ekeruche-Makinde; Anna Fuller; Emma Gostick; Kristin Ladell; Anna Lissina; Katy A Lloyd; Florian Madura; Katherine K Matthews; John J Miles; Johanne Pentier; David A Price; Pierre J Rizkallah; Brian M Baker; Tiffany K Baxter; Mathew Clement; david cole; Garry M Dolton; Emily S J Edwards; Linda Wooldridge; Andrew K Sewell
T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting.

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All Publications

2013: Julia Ekeruche-Makinde; Sian Llewellyn-Lacey; John J Miles; Kim M Miles; Mark Peakman; Johanne M Pentier; David A Price; Pierre J Rizkallah; Jamie Rossjohn; Andrea J A Schauenburg; Andrew K Sewell; Ania Skowera; Mai Ping Tan; Andrew Trimby; Hugo A van den Berg; Tamsin Williams; Mick Bailey; Anna M Bulek; Scott R Burrows; Mathew Clement; david cole; Garry Dolton; Linda Wooldridge
Peptide length determines the outcome of TCR/peptide-MHCI engagement.
Blood 2013;121(7):1112-23.
2013: Robin R Knight; Deborah Kronenberg; Mark Peakman; Andrew K Sewell; Anna Bulek; david cole; Martin Eichmann; Guo Cai Huang; Linda Wooldridge; Min Zhao; Ania Skowera
Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity.
Diabetes 2013;62(1):205-13.
2012: Julia Ekeruche-Makinde; Anna Fuller; Emma Gostick; Kristin Ladell; Anna Lissina; Katy A Lloyd; Florian Madura; Katherine K Matthews; John J Miles; Johanne Pentier; David A Price; Pierre J Rizkallah; Brian M Baker; Tiffany K Baxter; Mathew Clement; david cole; Garry M Dolton; Emily S J Edwards; Linda Wooldridge; Andrew K Sewell
T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting.
The Journal of biological chemistry 2012;287(44):37269-81.
2012: david cole; Bruno Laugel; David A Price; Mathew Clement; Linda Wooldridge; Andrew K Sewell
The molecular determinants of CD8 co-receptor function.
Immunology 2012;137(2):139-48.
2012: Anna M Bulek; Anna Fuller; Christopher J Holland; Florian Madura; Pierre J Rizkallah; Andrea J A Schauenburg; Andrew K Sewell; david cole
TCR/pMHC Optimized Protein crystallization Screen.
Journal of immunological methods 2012;382(1-2):203-10.
2012: Anna M Bulek; david cole; Garry Dolton; Jan W Drijfhout; Anna Fuller; Emma Gostick; Stephanie Gras; Guo C Huang; Bent K Jakobsen; Robin R Knight; Nikolai M Lissin; Florian Madura; John J Miles; Peter E Molloy; Mark Peakman; David A Price; Pierre J Rizkallah; Jamie Rossjohn; Ania Skowera; Linda Wooldridge; Andrew K Sewell
Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
Nature immunology 2012;13(3):283-9.
2011: Bruno Laugel; David A Price; Mathew Clement; david cole; Linda Wooldridge; Andrew K Sewell
The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells.
Journal of leukocyte biology 2011;90(6):1089-99.
2011: Mathew Clement; david cole; Garry Dolton; Emily S J Edwards; Julia Ekeruche-Makinde; Awen Gallimore; Andrew Godkin; Kristin Ladell; Sarah Lauder; John J Miles; David A Price; Andrea J A Schauenburg; Andrew K Sewell; Tamsin Williams; Scott R Burrows; Linda Wooldridge
Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(2):654-63.
2011: Kim M Miles; John J Miles; Florian Madura; Andrew K Sewell; david cole
Real time detection of peptide-MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability.
Molecular immunology 2011;48(4):728-32.
2010: david cole; Emily S J Edwards; Katherine K Wynn; Mathew Clement; John J Miles; Kristin Ladell; Julia Ekeruche; Emma Gostick; Katherine J Adams; Ania Skowera; Mark Peakman; Linda Wooldridge; David A Price; Andrew K Sewell
Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(4):2600-10.
2010: Linda Wooldridge; Mathew Clement; Anna Lissina; Emily S J Edwards; Kristin Ladell; Julia Ekeruche; Rachel E Hewitt; Bruno Laugel; Emma Gostick; david cole; Reno Debets; Cor Berrevoets; John J Miles; Scott R Burrows; David A Price; Andrew K Sewell
MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(7):3357-66.
2009: Oleg Y Borbulevych; Kurt H Piepenbrink; Brian E Gloor; Daniel R Scott; Ruth F Sommese; david cole; Andrew K Sewell; Brian M Baker
T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility.
Immunity 2009;31(6):885-96.
2009: Claire Horlock; Bryony Stott; Julian Dyson; Graham Ogg; Tess McPherson; Louise Jones; Andrew K Sewell; Linda Wooldridge; david cole; Justin Stebbing; Philip Savage
ELISPOT and functional T cell analyses using HLA mono-specific target cells.
Journal of immunological methods 2009;350(1-2):150-60.
2009: david cole; Fang Yuan; Pierre J Rizkallah; John J Miles; Emma Gostick; David A Price; George F Gao; Bent K Jakobsen; Andrew K Sewell
Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor.
The Journal of biological chemistry 2009;284(40):27281-9.
2009: Kaushik Choudhuri; Mathew Parker; Anita Milicic; david cole; Michael K Shaw; Andrew K Sewell; Guillaume Stewart-Jones; Tao Dong; Keith G Gould; Philip van der Merwe
Peptide-major histocompatibility complex dimensions control proximal kinase-phosphatase balance during T cell activation.
The Journal of biological chemistry 2009;284(38):26096-105.
2009: Linda Wooldridge; Anna Lissina; david cole; Hugo A van den Berg; David A Price; Andrew K Sewell
Tricks with tetramers: how to get the most from multimeric peptide-MHC.
Immunology 2009;126(2):147-64.
2008: Angel Varela-Rohena; Peter E Molloy; Steven M Dunn; Yi Li; Megan M Suhoski; Richard G Carroll; Anita Milicic; Tara Mahon; Deborah H Sutton; Bruno Laugel; Ruth Moysey; Brian J Cameron; Annelise Vuidepot; Marco A Purbhoo; david cole; Rodney E Phillips; Carl H June; Bent K Jakobsen; Andrew K Sewell; James L Riley
Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor.
Nature medicine 2008;14(12):1390-5.
2008: J Joseph Melenhorst; Phillip Scheinberg; Pratip K Chattopadhyay; Anna Lissina; Emma Gostick; david cole; Linda Wooldridge; Hugo A van den Berg; Ethan Bornstein; Nancy Hensel; Daniel C Douek; Mario Roederer; Andrew K Sewell; A John Barrett; David A Price
Detection of low avidity CD8(+) T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers.
Journal of immunological methods 2008;338(1-2):31-9.
2008: david cole; Steven M Dunn; malkit sami; Jonathan M Boulter; Bent K Jakobsen; Andrew K Sewell
T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding.
Molecular immunology 2008;45(9):2700-9.
2007: Bruno Laugel; Hugo A van den Berg; Emma Gostick; david cole; Linda Wooldridge; Jonathan M Boulter; Anita Milicic; David A Price; Andrew K Sewell
Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotoxic T lymphocyte activation and tetramer binding properties.
The Journal of biological chemistry 2007;282(33):23799-810.
2007: david cole; Nicholas Pumphrey; Jonathan M Boulter; malkit sami; John I Bell; Emma Gostick; David A Price; George F Gao; Andrew K Sewell; Bent K Jakobsen
Human TCR-binding affinity is governed by MHC class restriction.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5727-34.
2007: david cole; Pierre J Rizkallah; Jonathan M Boulter; malkit sami; Annelise Vuidepot; Meir Glick; Feng Gao; John I Bell; Bent K Jakobsen; George F Gao
Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor.
Proteins 2007;67(1):65-74.
2007: Emma Gostick; david cole; Sarah L Hutchinson; Linda Wooldridge; Sabrina Tafuro; Bruno Laugel; Anna Lissina; Annette Oxenius; Jonathan M Boulter; David A Price; Andrew K Sewell
Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor.
European journal of immunology 2007;37(2):479-86.
2006: david cole; Pierre J Rizkallah; Feng Gao; Neil I Watson; Jonathan M Boulter; John I Bell; malkit sami; George F Gao; Bent K Jakobsen
Crystal structure of HLA-A*2402 complexed with a telomerase peptide.
European journal of immunology 2006;36(1):170-9.
2005: david cole; Pierre J Rizkallah; malkit sami; Nikolai M Lissin; Feng Gao; John I Bell; Jonathan M Boulter; Meir Glick; Annelise Vuidepot; Bent K Jakobsen; George F Gao
Crystallization and preliminary X-ray structural studies of a high-affinity CD8alphaalpha co-receptor to pMHC.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 3):285-7.
2004: Yanhui Xu; Jieqing Zhu; Yueyong Liu; Zhiyong Lou; Fang Yuan; Yiwei Liu; david cole; Ling Ni; Nan Su; Lan Qin; Xu Li; Zhihong Bai; John I Bell; Hai Pang; Po Tien; George F Gao; Zihe Rao
Characterization of the heptad repeat regions, HR1 and HR2, and design of a fusion core structure model of the spike protein from severe acute respiratory syndrome (SARS) coronavirus.
Biochemistry 2004;43(44):14064-71.
2004: Yanhui Xu; david cole; Zhiyong Lou; Yiwei Liu; Lan Qin; Xu Li; Zhihong Bai; Fang Yuan; Zihe Rao; George F Gao
Construct design, biophysical, and biochemical characterization of the fusion core from mouse hepatitis virus (a coronavirus) spike protein.
Protein expression and purification 2004;38(1):116-22.
2004: Xiaojia Wang; Yanhui Xu; david cole; Zhiyong Lou; Yiwei Liu; Zihe Rao; Ming Wang; George F Gao
Biochemical, biophysical and preliminary X-ray crystallographic analyses of the fusion core of Sendai virus F protein.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 9):1632-5.
2004: Minghai Zhou; Yanhui Xu; Zhiyong Lou; david cole; Xiaojuan Li; Yiwei Liu; Po Tien; Zihe Rao; George F Gao
Complex assembly, crystallization and preliminary X-ray crystallographic studies of MHC H-2Kd complexed with an HBV-core nonapeptide.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 8):1473-5.
2004: Huimin Yan; Gengfu Xiao; Jiamin Zhang; Yuanyang Hu; Fang Yuan; david cole; Congyi Zheng; George F Gao
SARS coronavirus induces apoptosis in Vero E6 cells.
Journal of medical virology 2004;73(3):323-31.
2004: Jieqing Zhu; Gengfu Xiao; Yanhui Xu; Fang Yuan; Congyi Zheng; Yueyong Liu; Huimin Yan; david cole; John I Bell; Zihe Rao; Po Tien; George F Gao
Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors.
Biochemical and biophysical research communications 2004;319(1):283-8.
2004: Yanhui Xu; Zhiyong Lou; Yiwei Liu; david cole; Nan Su; Lan Qin; Xu Li; Zhihong Bai; Zihe Rao; George F Gao
Crystallization and preliminary crystallographic analysis of the fusion core from two new zoonotic paramyxoviruses, Nipah virus and Hendra virus.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 6):1161-4.
2004: david cole; George F Gao
CD8: adhesion molecule, co-receptor and immuno-modulator.
Cellular & molecular immunology 2004;1(2):81-8.
2004: Yanhui Xu; Shan Gao; david cole; Junjie Zhu; Nan Su; Hui Wang; George F Gao; Zihe Rao
Basis for fusion inhibition by peptides: analysis of the heptad repeat regions of the fusion proteins from Nipah and Hendra viruses, newly emergent zoonotic paramyxoviruses.
Biochemical and biophysical research communications 2004;315(3):664-70.