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Javier Casqueiro

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Esther Nistal; Leandro B Rodríguez-Aparicio; José M Ruiz de Morales; LE Sáenz de Miera; Santiago Vivas; Alberto Caminero; Javier Casqueiro
Differences in faecal bacteria populations and faecal bacteria metabolism in healthy adults and celiac disease patients.
Esther Nistal; Santiago Vivas; Luis E Sáenz de Miera; José M Ruiz de Morales; Alexandra R Herrán; Laura Arias; Paula Arroyo; Sara Calleja; Alberto Caminero; Javier Casqueiro
Differences of small intestinal bacteria populations in adults and children with/without celiac disease: effect of age, gluten diet, and disease.
Alberto Caminero; Laura Arias; Isabel Comino; José M Ruiz de Morales; Miguel A Ferrero; Esther Nistal; Ana Real; Leandro B Rodríguez-Aparicio; Carolina Sousa; Santiago Vivas; Javier Casqueiro
A gluten metabolism study in healthy individuals shows the presence of faecal glutenasic activity.

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All Publications

2012: Esther Nistal; Leandro B Rodríguez-Aparicio; José M Ruiz de Morales; LE Sáenz de Miera; Santiago Vivas; Alberto Caminero; Javier Casqueiro
Differences in faecal bacteria populations and faecal bacteria metabolism in healthy adults and celiac disease patients.
Biochimie 2012;94(8):1724-9.
2012: Esther Nistal; Santiago Vivas; Luis E Sáenz de Miera; José M Ruiz de Morales; Alexandra R Herrán; Laura Arias; Paula Arroyo; Sara Calleja; Alberto Caminero; Javier Casqueiro
Differences of small intestinal bacteria populations in adults and children with/without celiac disease: effect of age, gluten diet, and disease.
Inflammatory bowel diseases 2012;18(4):649-56.
2012: Alberto Caminero; Laura Arias; Isabel Comino; José M Ruiz de Morales; Miguel A Ferrero; Esther Nistal; Ana Real; Leandro B Rodríguez-Aparicio; Carolina Sousa; Santiago Vivas; Javier Casqueiro
A gluten metabolism study in healthy individuals shows the presence of faecal glutenasic activity.
European journal of nutrition 2012;51(3):293-9.
2012: Isabel Comino; Esther Nistal; Ana Real; Alfonso Rodríguez-Herrera; Miguel Ángel Síglez; Alberto Caminero; Javier Casqueiro; Angel Cebolla; Santiago Vivas; Carolina Sousa
Monitoring of gluten-free diet compliance in celiac patients by assessment of gliadin 33-mer equivalent epitopes in feces.
The American journal of clinical nutrition 2012;95(3):670-7.
2011: Sara Calleja; Javier Casqueiro; Mercedes Hernando; Esther Nistal; María Santiuste; Santiago Vivas; Laura Arias; Jose G Ruiz de Morales
Dynamics of non-conventional intraepithelial lymphocytes-NK, NKT, and γδ T-in celiac disease: relationship with age, diet, and histopathology.
Digestive diseases and sciences 2011;56(7):2042-9.
2011: Inmaculada Vaca; Javier Casqueiro; Renato Chávez; Angel Rumbero; Ricardo V Ullán; Juan F Martín
A preparative method for the purification of isopenicillin N from genetically blocked Acremonium chrysogenum strain TD189: studies on the degradation kinetics and storage conditions.
The Journal of antibiotics 2011;64(6):447-51.
2009: Franco Teves; Mónica Lamas-Maceiras; Carlos García-Estrada; Javier Casqueiro; Leopoldo Naranjo; Ricardo V Ullán; José-Martín Scervino; Xiaobin Wu; Tania Velasco-Conde; Juan F Martín
Transcriptional upregulation of four genes of the lysine biosynthetic pathway by homocitrate accumulation in Penicillium chrysogenum: homocitrate as a sensor of lysine-pathway distress.
Microbiology (Reading, England) 2009;155(Pt 12):3881-92.
2009: Santiago Vivas; Jose G Ruiz de Morales; sabino riestra; Laura Arias; Dolores Fuentes; Noemi Alvarez; Sara Calleja; Mercedes Hernando; Blanca Herrero; Javier Casqueiro; Luis Rodrigo
Duodenal biopsy may be avoided when high transglutaminase antibody titers are present.
World journal of gastroenterology : WJG 2009;15(38):4775-80.
2008: Santiago Vivas; Jose M Ruiz de Morales; Marisa Fernandez; Mercedes Hernando; Blanca Herrero; Javier Casqueiro; Santiago Gutierrez
Age-related clinical, serological, and histopathological features of celiac disease.
The American journal of gastroenterology 2008;103(9):2360-5; quiz 2366.
2007: Ricardo V Ullán; Sonia Campoy; Javier Casqueiro; Francisco J Fernández; Juan F Martín
Deacetylcephalosporin C production in Penicillium chrysogenum by expression of the isopenicillin N epimerization, ring expansion, and acetylation genes.
Chemistry & biology 2007;14(3):329-39.
2006: Mónica Lamas-Maceiras; Inmaculada Vaca; Esther Rodríguez; Javier Casqueiro; Juan F Martín
Amplification and disruption of the phenylacetyl-CoA ligase gene of Penicillium chrysogenum encoding an aryl-capping enzyme that supplies phenylacetic acid to the isopenicillin N-acyltransferase.
The Biochemical journal 2006;395(1):147-55.
2005: Leopoldo Naranjo; Mónica Lamas-Maceiras; Ricardo V Ullán; Sonia Campoy; Fernando Teijeira; Javier Casqueiro; Juan F Martín
Characterization of the oat1 gene of Penicillium chrysogenum encoding an omega-aminotransferase: induction by L-lysine, L-ornithine and L-arginine and repression by ammonium.
Molecular genetics and genomics : MGG 2005;274(3):283-94.
2005: E M Martín de Valmaseda; Sonia Campoy; Leopoldo Naranjo; Javier Casqueiro; Juan F Martín
Lysine is catabolized to 2-aminoadipic acid in Penicillium chrysogenum by an omega-aminotransferase and to saccharopine by a lysine 2-ketoglutarate reductase. Characterization of the omega-aminotransferase.
Molecular genetics and genomics : MGG 2005;274(3):272-82.
2005: Juan F Martín; Javier Casqueiro; Paloma Liras
Secretion systems for secondary metabolites: how producer cells send out messages of intercellular communication.
Current opinion in microbiology 2005;8(3):282-93.
2004: Ricardo V Ullán; Javier Casqueiro; Leopoldo Naranjo; Inmaculada Vaca; Juan F Martín
Expression of cefD2 and the conversion of isopenicillin N into penicillin N by the two-component epimerase system are rate-limiting steps in cephalosporin biosynthesis.
Molecular genetics and genomics : MGG 2004;272(5):562-70.
2004: Leopoldo Naranjo; Eva Martín de Valmaseda; Javier Casqueiro; Ricardo V Ullán; Mónica Lamas-Maceiras; Oscar Bañuelos; Juan F Martín
Inactivation of the lys7 gene, encoding saccharopine reductase in Penicillium chrysogenum, leads to accumulation of the secondary metabolite precursors piperideine-6-carboxylic acid and pipecolic acid from alpha-aminoadipic acid.
Applied and environmental microbiology 2004;70(2):1031-9.
2004: Juan F Martín; Ricardo V Ullán; Javier Casqueiro
Novel genes involved in cephalosporin biosynthesis: the three-component isopenicillin N epimerase system.
Advances in biochemical engineering/biotechnology 2004;88():91-109.
2003: Oscar Bañuelos; Leopoldo Naranjo; Javier Casqueiro; Santiago Gutiérrez; Juan F Martín
Co-transformation with autonomous replicating and integrative plasmids in Penicillium chrysogenum is highly efficient and leads in some cases to rescue of the intact integrative plasmid.
Fungal genetics and biology : FG & B 2003;40(2):83-92.
2003: Rosa Elena Cardoza; Santiago Gutiérrez; N Ortega; A Colina; Javier Casqueiro; Juan F Martín
Expression of a synthetic copy of the bovine chymosin gene in Aspergillus awamori from constitutive and pH-regulated promoters and secretion using two different pre-pro sequences.
Biotechnology and bioengineering 2003;83(3):249-59.
2002: Ricardo V Ullan; Javier Casqueiro; Oscar Banuelos; Francisco J Fernandez; Santiago Gutierrez; Juan F Martin
A novel epimerization system in fungal secondary metabolism involved in the conversion of isopenicillin N into penicillin N in Acremonium chrysogenum.
The Journal of biological chemistry 2002;277(48):46216-25.
2002: Ricardo V Ullán; G Liu; Javier Casqueiro; Santiago Gutiérrez; Oscar Bañuelos; Juan F Martín
The cefT gene of Acremonium chrysogenum C10 encodes a putative multidrug efflux pump protein that significantly increases cephalosporin C production.
Molecular genetics and genomics : MGG 2002;267(5):673-83.
2002: Oscar Bañuelos; Javier Casqueiro; S Steidl; Santiago Gutiérrez; Axel A Brakhage; Juan F Martín
Subcellular localization of the homocitrate synthase in Penicillium chrysogenum.
Molecular genetics and genomics : MGG 2002;266(5):711-9.
2001: Leopoldo Naranjo; E Martin de Valmaseda; Oscar Bañuelos; P Lopez; Jorge Riaño; Javier Casqueiro; JF Martin
Conversion of pipecolic acid into lysine in Penicillium chrysogenum requires pipecolate oxidase and saccharopine reductase: characterization of the lys7 gene encoding saccharopine reductase.
Journal of bacteriology 2001;183(24):7165-72.
2001: Javier Velasco; Santiago Gutiérrez; Javier Casqueiro; Francisco Fierro; Sonia Campoy; Juan F Martín
Cloning and characterization of the gene cahB encoding a cephalosporin C acetylhydrolase from Acremonium chrysogenum.
Applied microbiology and biotechnology 2001;57(3):350-6.
2001: Oscar Bañuelos; Javier Casqueiro; Santiago Gutiérrez; Juan F Martín
Intrachromosomal recombination after targeted monocopy integration in Penicillium chrysogenum: stabilization of the direct repeats to prevent loss of the inserted gene.
Current genetics 2001;39(4):231-6.
2001: G Liu; Javier Casqueiro; Oscar Bañuelos; Rosa Elena Cardoza; Santiago Gutiérrez; Juan F Martín
Targeted inactivation of the mecB gene, encoding cystathionine-gamma-lyase, shows that the reverse transsulfuration pathway is required for high-level cephalosporin biosynthesis in Acremonium chrysogenum C10 but not for methionine induction of the cephalosporin genes.
Journal of bacteriology 2001;183(5):1765-72.
2001: Maria José Hijarrubia; Jesus Aparicio; Javier Casqueiro; Juan F Martín
Characterization of the lys2 gene of Acremonium chrysogenum encoding a functional alpha-aminoadipate activating and reducing enzyme.
Molecular & general genetics : MGG 2001;264(6):755-62.
2000: Oscar Bañuelos; Javier Casqueiro; Santiago Gutiérrez; Juan F Martín
Overexpression of the lys1 gene in Penicillium chrysogenum: homocitrate synthase levels, alpha-aminoadipic acid pool and penicillin production.
Applied microbiology and biotechnology 2000;54(1):69-77.
2000: S Gutiérrez; Javier Casqueiro; J F Martín
[Filamentous fungi as cellular factories: Biodiversity of secondary metabolites].
Revista iberoamericana de micología 2000;17(1):S54-60.
2000: Oscar Bañuelos; Javier Casqueiro; Santiago Gutiérrez; Jorge Riaño; Juan F Martín
The specific transport system for lysine is fully inhibited by ammonium in Penicillium chrysogenum: an ammonium-insensitive system allows uptake in carbon-starved cells.
Antonie van Leeuwenhoek 2000;77(1):91-100.
1999: Javier Casqueiro; Oscar Bañuelos; Santiago Gutiérrez; Maria José Hijarrubia; Juan F Martín
Intrachromosomal recombination between direct repeats in Penicillium chrysogenum: gene conversion and deletion events.
Molecular & general genetics : MGG 1999;261(6):994-1000.
1999: Santiago Gutiérrez; Ana Teresa Marcos; Javier Casqueiro; K Kosalková; Francisco J Fernández; Javier Velasco; Juan F Martín
Transcription of the pcbAB, pcbC and penDE genes of Penicillium chrysogenum AS-P-78 is repressed by glucose and the repression is not reversed by alkaline pHs.
Microbiology (Reading, England) 1999;145 ( Pt 2)():317-24.
1999: Javier Casqueiro; Santiago Gutiérrez; Oscar Bañuelos; Maria José Hijarrubia; Juan F Martín
Gene targeting in Penicillium chrysogenum: disruption of the lys2 gene leads to penicillin overproduction.
Journal of bacteriology 1999;181(4):1181-8.
1999: Oscar Bañuelos; Javier Casqueiro; Francisco Fierro; Maria José Hijarrubia; Santiago Gutiérrez; Juan F Martín
Characterization and lysine control of expression of the lys1 gene of Penicillium chrysogenum encoding homocitrate synthase.
Gene 1999;226(1):51-9.
1999: Santiago Gutiérrez; Francisco Fierro; Javier Casqueiro; Juan F Martín
Gene organization and plasticity of the beta-lactam genes in different filamentous fungi.
Antonie van Leeuwenhoek 1999;75(1-2):81-94.
1999: Juan F Martín; Javier Casqueiro; K Kosalková; Ana Teresa Marcos; Santiago Gutiérrez
Penicillin and cephalosporin biosynthesis: mechanism of carbon catabolite regulation of penicillin production.
Antonie van Leeuwenhoek 1999;75(1-2):21-31.
1998: Javier Casqueiro; Santiago Gutiérrez; Oscar Bañuelos; Francisco Fierro; Javier Velasco; Juan F Martín
Characterization of the lys2 gene of Penicillium chrysogenum encoding alpha-aminoadipic acid reductase.
Molecular & general genetics : MGG 1998;259(5):549-56.
1998: Rosa Elena Cardoza; Francisco J Moralejo; Santiago Gutiérrez; Javier Casqueiro; Francisco Fierro; Juan F Martín
Characterization and nitrogen-source regulation at the transcriptional level of the gdhA gene of Aspergillus awamori encoding an NADP-dependent glutamate dehydrogenase.
Current genetics 1998;34(1):50-9.
1997: Maria José Hijarrubia; Javier Casqueiro; Santiago Gutiérrez; Francisco J Fernández; Juan F Martín
Characterization of the bip gene of Aspergillus awamori encoding a protein with an HDEL retention signal homologous to the mammalian BiP involved in polypeptide secretion.
Current genetics 1997;32(2):139-46.