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Rahul Kohli

Research Profile

Chemicals & Drugs

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Amino Acid Sequences

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Publications

TOP 3
Rahul Kohli
Grand challenge commentary: The chemistry of a dynamic genome.
Moira A McMahon; Janet D Siliciano; Rahul Kohli; Robert Siliciano
Sensitivity of V75I HIV-1 reverse transcriptase mutant selected in vitro by acyclovir to anti-HIV drugs.
Rahul Kohli; Shaun R Abrams; Kiran S Gajula; Robert W Maul; Patricia J Gearhart; James T Stivers
A portable hot spot recognition loop transfers sequence preferences from APOBEC family members to activation-induced cytidine deaminase.

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All Publications

2010: Rahul Kohli
Grand challenge commentary: The chemistry of a dynamic genome.
Nature chemical biology 2010;6(12):866-8.
2010: Moira A McMahon; Janet D Siliciano; Rahul Kohli; Robert Siliciano
Sensitivity of V75I HIV-1 reverse transcriptase mutant selected in vitro by acyclovir to anti-HIV drugs.
AIDS (London, England) 2010;24(2):319-23.
2009: Rahul Kohli; Shaun R Abrams; Kiran S Gajula; Robert W Maul; Patricia J Gearhart; James T Stivers
A portable hot spot recognition loop transfers sequence preferences from APOBEC family members to activation-induced cytidine deaminase.
The Journal of biological chemistry 2009;284(34):22898-904.
2009: Roger S Ho; Rahul Kohli; Lisa L Maragakis
When to think of zebras.
The American journal of medicine 2009;122(5):424-6.
2008: Moira A McMahon; Janet D Siliciano; Jun Lai; Jun O Liu; James T Stivers; Robert Siliciano; Rahul Kohli
The antiherpetic drug acyclovir inhibits HIV replication and selects the V75I reverse transcriptase multidrug resistance mutation.
The Journal of biological chemistry 2008;283(46):31289-93.
2004: Ellen Yeh; Hening Lin; Susan L Clugston; Rahul Kohli; Christopher T Walsh
Enhanced macrocyclizing activity of the thioesterase from tyrocidine synthetase in presence of nonionic detergent.
Chemistry & biology 2004;11(11):1573-82.
2004: Ellen Yeh; Rahul Kohli; Steven D Bruner; Christopher T Walsh
Type II thioesterase restores activity of a NRPS module stalled with an aminoacyl-S-enzyme that cannot be elongated.
Chembiochem : a European journal of chemical biology 2004;5(9):1290-3.
2003: Rahul Kohli; Martin Burke; Junhua Tao; Christopher T Walsh
Chemoenzymatic route to macrocyclic hybrid peptide/polyketide-like molecules.
Journal of the American Chemical Society 2003;125(24):7160-1.
2003: Rahul Kohli; Christopher T Walsh
Enzymology of acyl chain macrocyclization in natural product biosynthesis.
Chemical communications (Cambridge, England) 2003;(3):297-307.
2002: Claire C Tseng; Steven D Bruner; Rahul Kohli; Mohamed A Marahiel; Christopher T Walsh; Stephan A Sieber
Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase.
Biochemistry 2002;41(45):13350-9.
2002: Rahul Kohli; Christopher T Walsh; Michael D Burkart
Biomimetic synthesis and optimization of cyclic peptide antibiotics.
Nature 2002;418(6898):658-61.
2002: Lusong Luo; Rahul Kohli; Megumi Onishi; Uwe Linne; Mohamed A Marahiel; Christopher T Walsh
Timing of epimerization and condensation reactions in nonribosomal peptide assembly lines: kinetic analysis of phenylalanine activating elongation modules of tyrocidine synthetase B.
Biochemistry 2002;41(29):9184-96.
2002: Steven D Bruner; Thomas Weber; Rahul Kohli; Dirk Schwarzer; Mohamed A Marahiel; Christopher T Walsh; Milton T Stubbs
Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE.
Structure (London, England : 1993) 2002;10(3):301-10.
2002: Rahul Kohli; Junichi Takagi; Christopher T Walsh
The thioesterase domain from a nonribosomal peptide synthetase as a cyclization catalyst for integrin binding peptides.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1247-52.
2001: Rahul Kohli; JW Trauger; D Schwarzer; Mohamed A Marahiel; Christopher T Walsh
Generality of peptide cyclization catalyzed by isolated thioesterase domains of nonribosomal peptide synthetases.
Biochemistry 2001;40(24):7099-108.
2001: JW Trauger; Rahul Kohli; Christopher T Walsh
Cyclization of backbone-substituted peptides catalyzed by the thioesterase domain from the tyrocidine nonribosomal peptide synthetase.
Biochemistry 2001;40(24):7092-8.
2001: Thomas A Keating; DE Ehmann; Rahul Kohli; C Gary Marshall; JW Trauger; Christopher T Walsh
Chain termination steps in nonribosomal peptide synthetase assembly lines: directed acyl-S-enzyme breakdown in antibiotic and siderophore biosynthesis.
Chembiochem : a European journal of chemical biology 2001;2(2):99-107.
2000: JW Trauger; Rahul Kohli; H D Mootz; Mohamed A Marahiel; Christopher T Walsh
Peptide cyclization catalysed by the thioesterase domain of tyrocidine synthetase.
Nature 2000;407(6801):215-8.
1999: D Xu; Rahul Kohli; Vincent Massey
The role of threonine 37 in flavin reactivity of the old yellow enzyme.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3556-61.
1998: Rahul Kohli; Vincent Massey
The oxidative half-reaction of Old Yellow Enzyme. The role of tyrosine 196.
The Journal of biological chemistry 1998;273(49):32763-70.
1998: Rahul Kohli
Site-directed mutagenesis using PCR-mediated introduction of silent mutations.
BioTechniques 1998;25(2):184-8.