FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Seng Cheng

Research Profile

Living Beings

Procedures

Genetic Therapy

Chemicals & Drugs

Devices

Gene Transfer Techniques

Disorders

Anatomy

Physiology

Genes & Molecular Sequences

Transgenes

Co-author Network

Publications

TOP 3
Gerry McLachlan; Hazel Painter; David J Porteous; Ian Pringle; Ronald K Scheule; D J Shaw; B Stevenson; Stephanie G Sumner-Jones; P Tennant; Christina Vrettou; A Wilson; Heather Davidson; J C Davies; Lee A Davies; Ann Doherty; Deborah R Gill; C Gordon; Uta Griesenbach; E Holder; Stephen C Hyde; L Hyndman; J A Innes; Eric W F W Alton; Alison Baker; Renald Blundell; A Christopher Boyd; Seng Cheng; R L Coles; D D S Collie
Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung.
James C Dodge; Christopher M Treleaven; Jonathan A Fidler; Mark Hester; Amanda Haidet; Chalonda Handy; Meghan Rao; Amy Eagle; Jennifer C Matthews; Tatyana V Taksir; Seng Cheng; Lamya S Shihabuddin; Brian K Kaspar
AAV4-mediated expression of IGF-1 and VEGF within cellular components of the ventricular system improves survival outcome in familial ALS mice.
Qiuming Chu; Rodney Moreland; Lan Gao; Kristin M Taylor; Elizabeth Meyers; Seng Cheng; Ronald K Scheule
Induction of immune tolerance to a therapeutic protein by intrathymic gene delivery.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Seng Cheng (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2011: Gerry McLachlan; Hazel Painter; David J Porteous; Ian Pringle; Ronald K Scheule; D J Shaw; B Stevenson; Stephanie G Sumner-Jones; P Tennant; Christina Vrettou; A Wilson; Heather Davidson; J C Davies; Lee A Davies; Ann Doherty; Deborah R Gill; C Gordon; Uta Griesenbach; E Holder; Stephen C Hyde; L Hyndman; J A Innes; Eric W F W Alton; Alison Baker; Renald Blundell; A Christopher Boyd; Seng Cheng; R L Coles; D D S Collie
Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung.
Gene therapy 2011;18(10):996-1005.
2010: James C Dodge; Christopher M Treleaven; Jonathan A Fidler; Mark Hester; Amanda Haidet; Chalonda Handy; Meghan Rao; Amy Eagle; Jennifer C Matthews; Tatyana V Taksir; Seng Cheng; Lamya S Shihabuddin; Brian K Kaspar
AAV4-mediated expression of IGF-1 and VEGF within cellular components of the ventricular system improves survival outcome in familial ALS mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(12):2075-84.
2010: Qiuming Chu; Rodney Moreland; Lan Gao; Kristin M Taylor; Elizabeth Meyers; Seng Cheng; Ronald K Scheule
Induction of immune tolerance to a therapeutic protein by intrathymic gene delivery.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(12):2146-54.
2010: Gregory D Hurlbut; Robin J Ziegler; Jennifer B Nietupski; Joseph W Foley; LA Woodworth; Elizabeth Meyers; Scott D Bercury; Nilesh N Pande; David W Souza; Mark P Bree; Michael J Lukason; John Marshall; Seng Cheng; Ronald K Scheule
Preexisting immunity and low expression in primates highlight translational challenges for liver-directed AAV8-mediated gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(11):1983-94.
2010: M A Cabrera-Salazar; S D Bercury; R J Ziegler; J Marshall; B L Hodges; W-L Chuang; J Pacheco; L Li; Seng Cheng; R K Scheule
Intracerebroventricular delivery of glucocerebrosidase reduces substrates and increases lifespan in a mouse model of neuronopathic Gaucher disease.
Experimental neurology 2010;225(2):436-44.
2010: Joseph W Foley; Scott D Bercury; Patrick Finn; Seng Cheng; Ronald K Scheule; Robin J Ziegler
Evaluation of systemic follistatin as an adjuvant to stimulate muscle repair and improve motor function in Pompe mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(9):1584-91.
2010: E Aguilar Salegio; A P Kells; Mark Richardson; Piotr Hadaczek; John R Forsayeth; John Bringas; S P Sardi; M A Passini; L S Shihabuddin; Seng Cheng; Massimo Fiandaca; Krystof Bankiewicz
Magnetic resonance imaging-guided delivery of adeno-associated virus type 2 to the primate brain for the treatment of lysosomal storage disorders.
Human gene therapy 2010;21(9):1093-103.
2010: Andrew J Leger; Allison Altobelli; Leocadia M Mosquea; Adam J Belanger; Antonius Song; Seng Cheng; Canwen Jiang; Nelson S Yew
Inhibition of osteoclastogenesis by prolyl hydroxylase inhibitor dimethyloxallyl glycine.
Journal of bone and mineral metabolism 2010;28(5):510-9.
2010: Karen M Ashe; Kristin M Taylor; Qiuming Chu; Elizabeth Meyers; Allen Ellis; Varvara Jingozyan; Katherine Klinger; Patrick F Finn; Christopher G F Cooper; Wei-Lien Chuang; John Marshall; John M McPherson; Robert J Mattaliano; Seng Cheng; Ronald K Scheule; Rodney J Moreland
Inhibition of glycogen biosynthesis via mTORC1 suppression as an adjunct therapy for Pompe disease.
Molecular genetics and metabolism 2010;100(4):309-15.
2010: Jozsef Karman; Jennifer L Tedstone; Nathan K Gumlaw; Yunxiang Zhu; Nelson Yew; Craig Siegel; Shuling Guo; Andrew Siwkowski; Melanie C Ruzek; Canwen Jiang; Seng Cheng
Reducing glycosphingolipid biosynthesis in airway cells partially ameliorates disease manifestations in a mouse model of asthma.
International immunology 2010;22(7):593-603.
2010: Uta Griesenbach; Stephanie G Sumner-Jones; Emma Holder; Felix M Munkonge; Theresa Wodehouse; Stephen N Smith; Marguerite Y Wasowicz; Ian Pringle; Isabel Casamayor; Mario Chan; Rebecca Coles; Nikki Cornish; Ann Dewar; Ann Doherty; Raymond Farley; Anne-Marie Green; Bryony L Jones; Mia D B Larsen; Anna E Lawton; Michelle Manvell; Hazel Painter; Charanjit Singh; Lucinda Somerton; Barbara Stevenson; Anusha Varathalingam; Craig Siegel; Ronald K Scheule; Seng Cheng; Jane C Davies; David J Porteous; Deborah R Gill; A Christopher Boyd; Steve C Hyde; Eric W F W Alton
Limitations of the murine nose in the development of nonviral airway gene transfer.
American journal of respiratory cell and molecular biology 2010;43(1):46-54.
2010: John Marshall; Kerry Anne McEachern; Wei-Lien Chuang; Elizabeth Hutto; Craig S Siegel; James A Shayman; Greg A Grabowski; Ronald K Scheule; Diane P Copeland; Seng Cheng
Improved management of lysosomal glucosylceramide levels in a mouse model of type 1 Gaucher disease using enzyme and substrate reduction therapy.
Journal of inherited metabolic disease 2010;33(3):281-9.
2010: Marco A Passini; Jie Bu; Eric M Roskelley; Amy M Richards; S Pablo Sardi; Catherine R O'Riordan; Katherine W Klinger; Lamya S Shihabuddin; Seng Cheng
CNS-targeted gene therapy improves survival and motor function in a mouse model of spinal muscular atrophy.
The Journal of clinical investigation 2010;120(4):1253-64.
2010: Uta Griesenbach; Cuixiang Meng; Raymond Farley; Marguerite Y Wasowicz; Felix M Munkonge; Mario Chan; Charlotte Stoneham; Stephanie G Sumner-Jones; Ian A Pringle; Deborah R Gill; Stephen C Hyde; Barbara Stevenson; Emma Holder; Hiroshi Ban; Mamoru Hasegawa; Seng Cheng; Ronald K Scheule; Patrick L Sinn; Paul B McCray; Eric W F W Alton
The use of carboxymethylcellulose gel to increase non-viral gene transfer in mouse airways.
Biomaterials 2010;31(9):2665-72.
2010: John Marshall; Karen M Ashe; Dinesh Bangari; KerryAnne McEachern; Wei-Lien Chuang; Joshua Pacheco; Diane P Copeland; Robert J Desnick; James A Shayman; Ronald K Scheule; Seng Cheng
Substrate reduction augments the efficacy of enzyme therapy in a mouse model of Fabry disease.
PloS one 2010;5(11):e15033.
2010: Nelson S Yew; Hongmei Zhao; Eun-Gyoung Hong; I-Huan Wu; Malgorzata Przybylska; Craig Siegel; James A Shayman; Cynthia M Arbeeny; Jason K Kim; Canwen Jiang; Seng Cheng
Increased hepatic insulin action in diet-induced obese mice following inhibition of glucosylceramide synthase.
PloS one 2010;5(6):e11239.
2010: Stefania Xenariou; Hai-Dong Liang; Uta Griesenbach; Jie Zhu; Raymond Farley; Luci Somerton; Charanjit Singh; Peter K Jeffery; Ronald K Scheule; Seng Cheng; Duncan M Geddes; Martin J K Blomley; Eric W F W Alton
Low-frequency ultrasound increases non-viral gene transfer to the mouse lung.
Acta biochimica et biophysica Sinica 2010;42(1):45-51.
2010: Emma Holder; Barbara Stevenson; Raymond Farley; Tom Hilliard; Theresa Wodehouse; Lucinda Somerton; Mia Larsen; Jean O'Donoghue; Rebecca L Coles; Ronald K Scheule; Seng Cheng; Deborah R Gill; Stephen C Hyde; Uta Griesenbach; Eric W F W Alton; David J Porteous; A Christopher Boyd
Detection of CFTR transgene mRNA expression in respiratory epithelium isolated from the murine nasal cavity.
The journal of gene medicine 2010;12(1):55-63.
2010: Makiko Yasuda; David F Bishop; Mary Fowkes; Seng Cheng; Lin Gan; Robert J Desnick
AAV8-mediated gene therapy prevents induced biochemical attacks of acute intermittent porphyria and improves neuromotor function.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(1):17-22.
2009: Hongmei Zhao; Malgorzata Przybylska; I-Huan Wu; Jinhua Zhang; Panagiotis Maniatis; Joshua Pacheco; Peter Piepenhagen; Diane Copeland; Cynthia Arbeeny; James A Shayman; Johannes M Aerts; Canwen Jiang; Seng Cheng; Nelson S Yew
Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice.
Hepatology (Baltimore, Md.) 2009;50(1):85-93.
2009: Yunxiang Zhu; Ji-Lei Jiang; Nathan K Gumlaw; Jinhua Zhang; Scott D Bercury; Robin J Ziegler; Karen Lee; Mariko Kudo; William M Canfield; Timothy Edmunds; Canwen Jiang; Robert J Mattaliano; Seng Cheng
Glycoengineered acid alpha-glucosidase with improved efficacy at correcting the metabolic aberrations and motor function deficits in a mouse model of Pompe disease.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(6):954-63.
2009: Hidetoshi Kajiwara; Zhengyu Luo; Adam J Belanger; Akihiro Urabe; Karen A Vincent; Geoffrey Y Akita; Seng Cheng; Seibu Mochizuki; Richard J Gregory; Canwen Jiang
A hypoxic inducible factor-1 alpha hybrid enhances collateral development and reduces vascular leakage in diabetic rats.
The journal of gene medicine 2009;11(5):390-400.
2009: Robin J Ziegler; Claire Brown; Christine Barbon; Anne Marie D'Angona; Edward H Schuchman; Laura Andrews; Beth L Thurberg; John M McPherson; Kenneth P Karey; Seng Cheng
Pulmonary delivery of recombinant acid sphingomyelinase improves clearance of lysosomal sphingomyelin from the lungs of a murine model of Niemann-Pick disease.
Molecular genetics and metabolism 2009;97(1):35-42.
2009: Uta Griesenbach; Cuixiang Meng; Raymond Farley; Aaron Gardner; Maresa A Brake; Gad M Frankel; Dieter C Gruenert; Seng Cheng; Ronald K Scheule; Eric W F W Alton
The role of doxorubicin in non-viral gene transfer in the lung.
Biomaterials 2009;30(10):1971-7.
2009: James C Dodge; Jennifer Clarke; Christopher M Treleaven; Tatyana V Taksir; Denise A Griffiths; Wendy Yang; Jonathan A Fidler; Marco A Passini; Kenneth P Karey; Edward H Schuchman; Seng Cheng; Lamya S Shihabuddin
Intracerebroventricular infusion of acid sphingomyelinase corrects CNS manifestations in a mouse model of Niemann-Pick A disease.
Experimental neurology 2009;215(2):349-57.
2008: Richard L Sidman; Tatyana Taksir; Jonathan Fidler; Michael Zhao; James C Dodge; Marco A Passini; Nina Raben; Beth L Thurberg; Seng Cheng; Lamya S Shihabuddin
Temporal neuropathologic and behavioral phenotype of 6neo/6neo Pompe disease mice.
Journal of neuropathology and experimental neurology 2008;67(8):803-18.
2008: Robin J Ziegler; Scott D Bercury; Jonathan Fidler; Michael A Zhao; Joseph Foley; Tatyana V Taksir; Susan Ryan; Bradley L Hodges; Ronald K Scheule; Lamya S Shihabuddin; Seng Cheng
Ability of adeno-associated virus serotype 8-mediated hepatic expression of acid alpha-glucosidase to correct the biochemical and motor function deficits of presymptomatic and symptomatic Pompe mice.
Human gene therapy 2008;19(6):609-21.
2008: James C Dodge; Amanda M Haidet; Wendy Yang; Marco A Passini; Mark Hester; Jennifer Clarke; Eric M Roskelley; Christopher M Treleaven; Liza Rizo; Heather Martin; Soo H Kim; Rita Kaspar; Tatyana V Taksir; Denise A Griffiths; Seng Cheng; Lamya S Shihabuddin; Brian K Kaspar
Delivery of AAV-IGF-1 to the CNS extends survival in ALS mice through modification of aberrant glial cell activity.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(6):1056-64.
2008: Stephen C Hyde; Ian Pringle; Syahril Abdullah; Anna E Lawton; Lee A Davies; Anusha Varathalingam; Graciela Nunez-Alonso; Anne-Marie Green; Reto P Bazzani; Stephanie G Sumner-Jones; Mario Chan; Hongyu Li; Nelson S Yew; Seng Cheng; A Christopher Boyd; Jane C Davies; Uta Griesenbach; David J Porteous; David N Sheppard; Felix M Munkonge; Eric W F W Alton; Deborah R Gill
CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression.
Nature biotechnology 2008;26(5):549-51.
2008: Michael Chang; Jonathan D Cooper; David E Sleat; Seng Cheng; James C Dodge; Marco A Passini; Peter Lobel; Beverly L Davidson
Intraventricular enzyme replacement improves disease phenotypes in a mouse model of late infantile neuronal ceroid lipofuscinosis.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(4):649-56.
2008: Frank Jacobs; Jan Snoeys; Y Feng; E Van Craeyveld; joke lievens; D Armentano; Seng Cheng; Bart De Geest
Direct comparison of hepatocyte-specific expression cassettes following adenoviral and nonviral hydrodynamic gene transfer.
Gene therapy 2008;15(8):594-603.
2008: Uta Griesenbach; Cuixiang Meng; Raymond Farley; Seng Cheng; Ronald K Scheule; Mark H Davies; Paul C Wolstenholme-Hogg; Willem ten Hove; Paul van der Hoeven; Patrick L Sinn; Paul B McCray; Makoto Inoue; Duncan M Geddes; Mamoru Hasegawa; Gad Frankel; Siouxsie Wiles; Eric W F W Alton
In vivo imaging of gene transfer to the respiratory tract.
Biomaterials 2008;29(10):1533-40.
2008: M D B Larsen; Uta Griesenbach; S Goussard; Dieter C Gruenert; Duncan M Geddes; Ronald K Scheule; Seng Cheng; P Courvalin; Catherine Grillot-Courvalin; E W F W Alton
Bactofection of lung epithelial cells in vitro and in vivo using a genetically modified Escherichia coli.
Gene therapy 2008;15(6):434-42.
2007: Adam J Belanger; Zhengyu Luo; Karen A Vincent; Geoffrey Y Akita; Seng Cheng; Richard J Gregory; Canwen Jiang
Hypoxia-inducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of peroxisome proliferator-activated receptor alpha/retinoid X receptor.
Biochemical and biophysical research communications 2007;364(3):567-72.
2007: B L Alexander; R R Ali; E W F Alton; J W Bainbridge; S Braun; Seng Cheng; T R Flotte; H B Gaspar; M Grez; U Griesenbach; Michael Gordon Kaplitt; M G Ott; R Seger; M Simons; A J Thrasher; A Z Thrasher; S Ylä-Herttuala
Progress and prospects: gene therapy clinical trials (part 1).
Gene therapy 2007;14(20):1439-47.
2007: Wendy W Yang; James C Dodge; Marco A Passini; Tatyana V Taksir; Denise Griffiths; Edward H Schuchman; Seng Cheng; Lamya S Shihabuddin
Intraparenchymal injections of acid sphingomyelinase results in regional correction of lysosomal storage pathology in the Niemann-Pick A mouse.
Experimental neurology 2007;207(2):258-66.
2007: Mario A Cabrera-Salazar; Eric M Roskelley; Jie Bu; Bradley L Hodges; Nelson S Yew; James C Dodge; Lamya S Shihabuddin; Istvan Sohar; David E Sleat; Ronald K Scheule; Beverly L Davidson; Seng Cheng; Peter Lobel; Marco A Passini
Timing of therapeutic intervention determines functional and survival outcomes in a mouse model of late infantile batten disease.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(10):1782-8.
2007: Makiko Yasuda; Maciej E Domaradzki; Donna Armentano; Seng Cheng; David F Bishop; Robert J Desnick
Acute intermittent porphyria: vector optimization for gene therapy.
The journal of gene medicine 2007;9(9):806-11.
2007: Kerry Anne McEachern; John Fung; Svetlana Komarnitsky; Craig S Siegel; Wei-Lien Chuang; Elizabeth Hutto; James A Shayman; Gregory A Grabowski; johannes aerts; Seng Cheng; Diane P Copeland; John Marshall
A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy of Gaucher disease.
Molecular genetics and metabolism 2007;91(3):259-67.
2007: Marco A Passini; Jie Bu; Jonathan A Fidler; Robin J Ziegler; Joseph W Foley; James C Dodge; Wendy W Yang; Jennifer Clarke; Tatyana V Taksir; Denise A Griffiths; Michael A Zhao; Catherine R O'Riordan; Edward H Schuchman; Lamya S Shihabuddin; Seng Cheng
Combination brain and systemic injections of AAV provide maximal functional and survival benefits in the Niemann-Pick mouse.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(22):9505-10.
2007: Hongmei Zhao; Malgorzata Przybylska; I-Huan Wu; Jinhua Zhang; Craig Siegel; Svetlana Komarnitsky; Nelson S Yew; Seng Cheng
Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes.
Diabetes 2007;56(5):1210-8.
2007: Ian Pringle; Gerry McLachlan; D D S Collie; Stephanie G Sumner-Jones; Anna E Lawton; Peter Tennant; Alison Baker; Catherine Gordon; Richard Blundell; Anusha Varathalingam; Lee A Davies; Ralph A Schmid; Seng Cheng; David J Porteous; Deborah R Gill; Stephen C Hyde
Electroporation enhances reporter gene expression following delivery of naked plasmid DNA to the lung.
The journal of gene medicine 2007;9(5):369-80.
2007: Stefania Xenariou; Uta Griesenbach; Hai-Dong Liang; Jie Zhu; Raymond Farley; Luci Somerton; Charanjit Singh; Peter K Jeffery; Stefano Ferrari; Ronald K Scheule; Seng Cheng; Duncan M Geddes; Martin J K Blomley; Eric W F W Alton
Use of ultrasound to enhance nonviral lung gene transfer in vivo.
Gene therapy 2007;14(9):768-74.
2007: Lee A Davies; Claire Seguela; Anusha Varathalingam; Seng Cheng; Stephen C Hyde; Deborah R Gill
Identification of transfected cell types following non-viral gene transfer to the murine lung.
The journal of gene medicine 2007;9(3):184-96.
2007: Robin J Ziegler; Maribeth Cherry; Christine Barbon; Chester Li; Scott D Bercury; Donna Armentano; Robert J Desnick; Seng Cheng
Correction of the biochemical and functional deficits in fabry mice following AAV8-mediated hepatic expression of alpha-galactosidase A.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(3):492-500.
2007: Gerry McLachlan; Alison Baker; Peter Tennant; Catherine Gordon; Christina Vrettou; Louise Renwick; Richard Blundell; Seng Cheng; Ronald K Scheule; Lee Davies; Hazel Painter; Rebecca L Coles; Anna E Lawton; Chris Marriott; Deborah R Gill; Stephen C Hyde; Uta Griesenbach; Eric W F W Alton; A Christopher Boyd; David J Porteous; D D S Collie
Optimizing aerosol gene delivery and expression in the ovine lung.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(2):348-54.
2006: Reuben Matalon; Sankar Surendran; Gerald Campbell; Kimberlee Michals-Matalon; Stephen K Tyring; James Grady; Seng Cheng; Edward Kaye
Hyaluronidase increases the biodistribution of acid alpha-1,4 glucosidase in the muscle of Pompe disease mice: an approach to enhance the efficacy of enzyme replacement therapy.
Biochemical and biophysical research communications 2006;350(3):783-7.
2006: Stefania Xenariou; Uta Griesenbach; Stefano Ferrari; P Dean; Ronald K Scheule; Seng Cheng; Duncan M Geddes; C Plank; Eric W F W Alton
Using magnetic forces to enhance non-viral gene transfer to airway epithelium in vivo.
Gene therapy 2006;13(21):1545-52.
2006: M Begoña Cachón-González; Susan Z Wang; Andrew Lynch; Robin Ziegler; Seng Cheng; Timothy M Cox
Effective gene therapy in an authentic model of Tay-Sachs-related diseases.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(27):10373-8.
2006: Kerry Anne McEachern; Jennifer B Nietupski; Wei-Lien Chuang; Donna Armentano; Jennifer Johnson; Elizabeth Hutto; Gregory A Grabowski; Seng Cheng; John Marshall
AAV8-mediated expression of glucocerebrosidase ameliorates the storage pathology in the visceral organs of a mouse model of Gaucher disease.
The journal of gene medicine 2006;8(6):719-29.
2006: Bradley L Hodges; Seng Cheng
Cell and gene-based therapies for the lysosomal storage diseases.
Current gene therapy 2006;6(2):227-41.
2006: Marco A Passini; James C Dodge; Jie Bu; Wendy Yang; Qi Zhao; Dolan Sondhi; Neil R Hackett; Stephen M Kaminsky; Qinwen Mao; Lamya S Shihabuddin; Seng Cheng; David E Sleat; Gregory R Stewart; Beverly L Davidson; Peter Lobel; Helen-Ann Brown Epstein
Intracranial delivery of CLN2 reduces brain pathology in a mouse model of classical late infantile neuronal ceroid lipofuscinosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(5):1334-42.
2006: Uta Griesenbach; Chris Kitson; Sara Escudero Garcia; Raymond Farley; Charanjit Singh; Luci Somerton; Hazel Painter; Rbecca L Smith; Deborah R Gill; Stephen C Hyde; Yu-Hua Chow; Jim Hu; Mike Gray; Mark Edbrooke; Varrie Ogilvie; Gordon MacGregor; Ronald K Scheule; Seng Cheng; Natasha J Caplen; Eric W F W Alton
Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo.
Respiratory research 2006;7():26.
2005: James C Dodge; Jennifer Clarke; Antonius Song; Jie Bu; Wendy Yang; Tatyana V Taksir; Denise Griffiths; Michael A Zhao; Edward H Schuchman; Seng Cheng; Catherine R O'Riordan; Lamya S Shihabuddin; Marco A Passini; Gregory R Stewart
Gene transfer of human acid sphingomyelinase corrects neuropathology and motor deficits in a mouse model of Niemann-Pick type A disease.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(49):17822-7.
2005: Christine Barbon; Robin J Ziegler; Chester Li; Donna Armentano; Maribeth Cherry; Robert J Desnick; Edward H Schuchman; Seng Cheng
AAV8-mediated hepatic expression of acid sphingomyelinase corrects the metabolic defect in the visceral organs of a mouse model of Niemann-Pick disease.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(3):431-40.
2005: Yunxiang Zhu; Xuemei Li; Alison McVie-Wylie; Canwen Jiang; Beth L Thurberg; Nina Raben; Robert J Mattaliano; Seng Cheng
Carbohydrate-remodelled acid alpha-glucosidase with higher affinity for the cation-independent mannose 6-phosphate receptor demonstrates improved delivery to muscles of Pompe mice.
The Biochemical journal 2005;389(Pt 3):619-28.
2005: Ian Pringle; S Raman; W W Sharp; Seng Cheng; Stephen C Hyde; Deborah R Gill
Detection of plasmid DNA vectors following gene transfer to the murine airways.
Gene therapy 2005;12(15):1206-14.
2005: Zhengyu Luo; Geoffrey Y Akita; Taro Date; Christopher Treleaven; Karen A Vincent; Denise Woodcock; Seng Cheng; Richard J Gregory; Canwen Jiang
Adenovirus-mediated expression of beta-adrenergic receptor kinase C-terminus reduces intimal hyperplasia and luminal stenosis of arteriovenous polytetrafluoroethylene grafts in pigs.
Circulation 2005;111(13):1679-84.
2005: Taro Date; Seibu Mochizuki; Adam J Belanger; Midori Yamakawa; Zhengyu Luo; Karen A Vincent; Seng Cheng; Richard J Gregory; Canwen Jiang
Expression of constitutively stable hybrid hypoxia-inducible factor-1alpha protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury.
American journal of physiology. Cell physiology 2005;288(2):C314-20.
2004: Yunxiang Zhu; Xuemei Li; Josephine Kyazike; Qun Zhou; Beth L Thurberg; Nina Raben; Robert J Mattaliano; Seng Cheng
Conjugation of mannose 6-phosphate-containing oligosaccharides to acid alpha-glucosidase improves the clearance of glycogen in pompe mice.
The Journal of biological chemistry 2004;279(48):50336-41.
2004: Nelson S Yew; Seng Cheng
Reducing the immunostimulatory activity of CpG-containing plasmid DNA vectors for non-viral gene therapy.
Expert opinion on drug delivery 2004;1(1):115-25.
2004: Zhengyu Luo; Maria Palasis; Midori Yamakawa; Louis X Liu; Karen A Vincent; Leonard Trudell; Geoffrey A Akita; Walter J Koch; Seng Cheng; Richard J Gregory; Canwen Jiang
Catheter-mediated delivery of adenoviral vectors expressing beta-adrenergic receptor kinase C-terminus inhibits intimal hyperplasia and luminal stenosis in rabbit iliac arteries.
The journal of gene medicine 2004;6(10):1061-8.
2004: Midori Yamakawa; Louis X Liu; Adam J Belanger; Taro Date; Takayuki Kuriyama; Mark A Goldberg; Seng Cheng; Richard J Gregory; Canwen Jiang
Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis.
American journal of physiology. Renal physiology 2004;287(4):F649-57.
2004: Canwen Jiang; Yi-Feng Yang; Seng Cheng
Fas ligand gene therapy for vascular intimal hyperplasia.
Current gene therapy 2004;4(1):33-9.
2004: Hongmei Zhao; Hiraoki Hemmi; Shizuo Akira; Seng Cheng; Ronald K Scheule; Nelson S Yew
Contribution of Toll-like receptor 9 signaling to the acute inflammatory response to nonviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(2):241-8.
2004: Robin J Ziegler; Scott M Lonning; Donna Armentano; Chester Li; David W Souza; Maribeth Cherry; Christine Ford; Christine Barbon; Robert J Desnick; Guangping Gao; James M Wilson; Richard Peluso; Simon Godwin; Barrie J Carter; Richard J Gregory; Samuel C Wadsworth; Seng Cheng
AAV2 vector harboring a liver-restricted promoter facilitates sustained expression of therapeutic levels of alpha-galactosidase A and the induction of immune tolerance in Fabry mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(2):231-40.
2004: Yunxiang Zhu; Xuemei Li; Edward H Schuchman; Robert J Desnick; Seng Cheng
Dexamethasone-mediated up-regulation of the mannose receptor improves the delivery of recombinant glucocerebrosidase to Gaucher macrophages.
The Journal of pharmacology and experimental therapeutics 2004;308(2):705-11.
2004: Malgorzata Przybylska; I-Huan Wu; Hongmei Zhao; Robin J Ziegler; Jennifer D Tousignant; Robert J Desnick; Ronald K Scheule; Seng Cheng; Nelson S Yew
Partial correction of the alpha-galactosidase A deficiency and reduction of glycolipid storage in Fabry mice using synthetic vectors.
The journal of gene medicine 2004;6(1):85-92.
2004: John Marshall; Nelson S Yew; Seng Cheng
Formulation of synthetic gene delivery vectors for transduction of the airway epithelium.
Methods in molecular biology (Clifton, N.J.) 2004;245():95-114.
2003: Midori Yamakawa; Louis X Liu; Taro Date; Adam J Belanger; Karen A Vincent; Geoffrey Y Akita; Takayuki Kuriyama; Seng Cheng; Richard J Gregory; Canwen Jiang
Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors.
Circulation research 2003;93(7):664-73.
2003: Michael Emerson; Louise Renwick; Stephen Tate; Susan Rhind; Elspeth Milne; Hazel Painter; A Christopher Boyd; Gerry McLachlan; Uta Griesenbach; Seng Cheng; Deborah R Gill; Stephen C Hyde; Alison Baker; Eric W F W Alton; David J Porteous; D D S Collie
Transfection efficiency and toxicity following delivery of naked plasmid DNA and cationic lipid-DNA complexes to ovine lung segments.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(4):646-53.
2003: Seng Cheng; A E Smith
Gene therapy progress and prospects: gene therapy of lysosomal storage disorders.
Gene therapy 2003;10(16):1275-81.
2003: Taro Date; Zhengyu Luo; Midori Yamakawa; Adam J Belanger; Abraham Scaria; Seng Cheng; Richard J Gregory; Seibu Mochizuki; Canwen Jiang
Myocardial expression of baculoviral p35 alleviates doxorubicin-induced cardiomyopathy in rats.
Human gene therapy 2003;14(10):947-57.
2003: Taro Date; Seibu Mochizuki; Adam J Belanger; Midori Yamakawa; Zhengyu Luo; Karen A Vincent; Seng Cheng; Richard J Gregory; Canwen Jiang
Differential effects of membrane and soluble Fas ligand on cardiomyocytes: role in ischemia/reperfusion injury.
Journal of molecular and cellular cardiology 2003;35(7):811-21.
2003: Jennifer D Tousignant; Hongmei Zhao; Nelson S Yew; Seng Cheng; Simon J Eastman; Ronald K Scheule
DNA sequences in cationic lipid:pDNA-mediated systemic toxicities.
Human gene therapy 2003;14(3):203-14.
2002: A C Rose; Catharine Goddard; William H Colledge; Seng Cheng; Deborah R Gill; Stephen C Hyde
Optimisation of real-time quantitative RT-PCR for the evaluation of non-viral mediated gene transfer to the airways.
Gene therapy 2002;9(19):1312-20.
2002: John Marshall; Kerry Anne McEachern; Julie A Cavanagh Kyros; Jennifer B Nietupski; Tracey Budzinski; Robin J Ziegler; Nelson S Yew; Jennifer Sullivan; Abraham Scaria; Nico van Rooijen; John A Barranger; Seng Cheng
Demonstration of feasibility of in vivo gene therapy for Gaucher disease using a chemically induced mouse model.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(2):179-89.
2002: Taro Date; Adam J Belanger; Seibu Mochizuki; Jennifer A Sullivan; Louis X Liu; Abraham Scaria; Seng Cheng; Richard J Gregory; Canwen Jiang
Adenovirus-mediated expression of p35 prevents hypoxia/reoxygenation injury by reducing reactive oxygen species and caspase activity.
Cardiovascular research 2002;55(2):309-19.
2002: Adam J Belanger; Hsienwie Lu; Taro Date; Louis X Liu; Karen A Vincent; Geoffrey Y Akita; Seng Cheng; Richard J Gregory; Canwen Jiang
Hypoxia up-regulates expression of peroxisome proliferator-activated receptor gamma angiopoietin-related gene (PGAR) in cardiomyocytes: role of hypoxia inducible factor 1alpha.
Journal of molecular and cellular cardiology 2002;34(7):765-74.
2002: Chester Li; Robin J Ziegler; Maribeth Cherry; Michael Lukason; Robert J Desnick; Nelson S Yew; Seng Cheng
Adenovirus-transduced lung as a portal for delivering alpha-galactosidase A into systemic circulation for Fabry disease.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(6):745-54.
2002: Nelson S Yew; Hongmei Zhao; Malgorzata Przybylska; I-Huan Wu; Jennifer D Tousignant; Ronald K Scheule; Seng Cheng
CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(6):731-8.
2002: Robin J Ziegler; Chester Li; Maribeth Cherry; Yunxiang Zhu; Donna Hempel; Nico van Rooijen; Yiannis A Ioannou; Robert J Desnick; Mark A Goldberg; Nelson S Yew; Seng Cheng
Correction of the nonlinear dose response improves the viability of adenoviral vectors for gene therapy of Fabry disease.
Human gene therapy 2002;13(8):935-45.
2002: Louis X Liu; Hsienwie Lu; Yuxia Luo; Taro Date; Adam J Belanger; Karen A Vincent; Geoffrey Y Akita; Mark Goldberg; Seng Cheng; Richard J Gregory; Canwen Jiang
Stabilization of vascular endothelial growth factor mRNA by hypoxia-inducible factor 1.
Biochemical and biophysical research communications 2002;291(4):908-14.
2002: Niek N Sanders; Stefaan C De Smedt; Seng Cheng; Jo Demeester
Pegylated GL67 lipoplexes retain their gene transfection activity after exposure to components of CF mucus.
Gene therapy 2002;9(6):363-71.
2002: Canwen Jiang; Hsienwie Lu; Karen A Vincent; Srinivas Shankara; Adam J Belanger; Seng Cheng; Geoffrey Y Akita; Ralph A Kelly; Mark A Goldberg; Richard J Gregory
Gene expression profiles in human cardiac cells subjected to hypoxia or expressing a hybrid form of HIF-1 alpha.
Physiological genomics 2002;8(1):23-32.
2002: John Marshall; Seng Cheng
Formulation of synthetic vectors for cystic fibrosis gene therapy.
Methods in molecular medicine 2002;70():585-98.
2001: Zhengyu Luo; T Garron; Maria Palasis; Hsienwie Lu; Adam J Belanger; Abraham Scaria; Karen A Vincent; Taro Date; Geoffrey Y Akita; Seng Cheng; J Barry; Richard J Gregory; Canwen Jiang
Enhancement of Fas ligand-induced inhibition of neointimal formation in rabbit femoral and iliac arteries by coexpression of p35.
Human gene therapy 2001;12(18):2191-202.
2001: Canwen Jiang; ER Lee; M B Lane; Y F Xiao; DJ Harris; Seng Cheng
Partial correction of defective Cl(-) secretion in cystic fibrosis epithelial cells by an analog of squalamine.
American journal of physiology. Lung cellular and molecular physiology 2001;281(5):L1164-72.
2001: Adam J Belanger; Abraham Scaria; Hsienwie Lu; Jennifer A Sullivan; Seng Cheng; Richard J Gregory; Canwen Jiang
Fas ligand/Fas-mediated apoptosis in human coronary artery smooth muscle cells: therapeutic implications of fratricidal mode of action.
Cardiovascular research 2001;51(4):749-61.
2001: Nelson S Yew; Seng Cheng
Gene therapy for lysosomal storage disorders.
Current opinion in molecular therapeutics 2001;3(4):399-406.
2001: Nelson S Yew; Malgorzata Przybylska; Robin J Ziegler; D Liu; Seng Cheng
High and sustained transgene expression in vivo from plasmid vectors containing a hybrid ubiquitin promoter.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;4(1):75-82.
2001: F E Ruiz; John P Clancy; Michael A Perricone; Zsuzsa Bebok; Jeong S Hong; Seng Cheng; DP Meeker; K Randall Young; R A Schoumacher; Mark R Weatherly; L Wing; James E Morris; L Sindel; M Rosenberg; Frederik W van Ginkel; Jerry R McGhee; D Kelly; Raymond Lyrene; Eric J Sorscher
A clinical inflammatory syndrome attributable to aerosolized lipid-DNA administration in cystic fibrosis.
Human gene therapy 2001;12(7):751-61.
2001: Qiuming Chu; J A St George; Michael Lukason; Seng Cheng; Ronald K Scheule; Simon J Eastman
EGTA enhancement of adenovirus-mediated gene transfer to mouse tracheal epithelium in vivo.
Human gene therapy 2001;12(5):455-67.
2000: Jennifer D Tousignant; A L Gates; L A Ingram; C L Johnson; JB Nietupski; Seng Cheng; Simon J Eastman; Ronald K Scheule
Comprehensive analysis of the acute toxicities induced by systemic administration of cationic lipid:plasmid DNA complexes in mice.
Human gene therapy 2000;11(18):2493-513.
2000: Catherine R O'Riordan; AL Lachapelle; J Marshall; Elizabeth Ann Higgins; Seng Cheng
Characterization of the oligosaccharide structures associated with the cystic fibrosis transmembrane conductance regulator.
Glycobiology 2000;10(11):1225-33.
2000: H Zhao; Seng Cheng; Nelson S Yew
Requirements for effective inhibition of immunostimulatory CpG motifs by neutralizing motifs.
Antisense & nucleic acid drug development 2000;10(5):381-9.
2000: Myra Stern; K Ulrich; C Robinson; J Copeland; Uta Griesenbach; C Masse; Seng Cheng; Felix M Munkonge; Duncan M Geddes; Y Berthiaume; Eric W F W Alton
Pretreatment with cationic lipid-mediated transfer of the Na+K+-ATPase pump in a mouse model in vivo augments resolution of high permeability pulmonary oedema.
Gene therapy 2000;7(11):960-6.
2000: Nelson S Yew; Hongmei Zhao; I-Huan Wu; A Song; Jennifer D Tousignant; Malgorzata Przybylska; Seng Cheng
Reduced inflammatory response to plasmid DNA vectors by elimination and inhibition of immunostimulatory CpG motifs.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(3):255-62.
2000: Adam Jaffé; Diane Judd; C Ratcliffe; Seng Cheng; Andrew Bush; Duncan M Geddes; Eric W F W Alton
Cationic lipid-mediated gene transfer to the growing murine and human airway.
Gene therapy 2000;7(4):273-8.
2000: John Marshall; JB Nietupski; ER Lee; C S Siegel; P W Rafter; S A Rudginsky; C D Chang; Simon J Eastman; DJ Harris; Ronald K Scheule; Seng Cheng
Cationic lipid structure and formulation considerations for optimal gene transfection of the lung.
Journal of drug targeting 2000;7(6):453-69.
1999: Alessandra Bragonzi; Alessandra Boletta; A Biffi; A Muggia; Giovanna Sersale; Seng Cheng; Claudio Bordignon; Baroukh M Assael; Massimo Conese
Comparison between cationic polymers and lipids in mediating systemic gene delivery to the lungs.
Gene therapy 1999;6(12):1995-2004.
1999: Nelson S Yew; John Marshall; Malgorzata Przybylska; D M Wysokenski; Robin J Ziegler; P W Rafter; Chester Li; Donna Armentano; Seng Cheng
Increased duration of transgene expression in the lung with plasmid DNA vectors harboring adenovirus E4 open reading frame 3.
Human gene therapy 1999;10(11):1833-43.
1999: Elizabeth Hillery; Seng Cheng; Duncan M Geddes; Eric W F W Alton
Effects of altering dosing on cationic liposome-mediated gene transfer to the respiratory epithelium.
Gene therapy 1999;6(7):1313-6.
1999: Robin J Ziegler; Nelson S Yew; Chester Li; Maribeth Cherry; P Berthelette; H Romanczuk; Yiannis A Ioannou; KM Zeidner; Robert J Desnick; Seng Cheng
Correction of enzymatic and lysosomal storage defects in Fabry mice by adenovirus-mediated gene transfer.
Human gene therapy 1999;10(10):1667-82.
1999: Tamas Jilling; I Y Haddad; Seng Cheng; Sadis Matalon
Nitric oxide inhibits heterologous CFTR expression in polarized epithelial cells.
The American journal of physiology 1999;277(1 Pt 1):L89-96.
1999: Canwen Jiang; Walter E Finkbeiner; Jonathan H Widdicombe; SL Fang; KX Wang; Jennifer B Nietupski; K M Hehir; Seng Cheng
Restoration of cyclic adenosine monophosphate-stimulated chloride channel activity in human cystic fibrosis tracheobronchial submucosal gland cells by adenovirus-mediated and cationic lipid-mediated gene transfer.
American journal of respiratory cell and molecular biology 1999;20(6):1107-15.
1999: Vijayakrishna K Gadi; Nianxiang Zou; JS Liu; Seng Cheng; Thomas R Broker; Eric J Sorscher; Louise T Chow
Components of human papillomavirus that activate transcription and support plasmid replication in human airway cells.
American journal of respiratory cell and molecular biology 1999;20(5):1001-6.
1999: Chris Kitson; B Angel; Diane Judd; Stephen Rothery; N J Severs; A Dewar; L Huang; S C Wadsworth; Seng Cheng; Duncan M Geddes; Eric W F W Alton
The extra- and intracellular barriers to lipid and adenovirus-mediated pulmonary gene transfer in native sheep airway epithelium.
Gene therapy 1999;6(4):534-46.
1999: Eric W F W Alton; Myra Stern; Raymond Farley; Adam Jaffe; Sharon Chadwick; J Phillips; J Davies; Stephen N Smith; J Browning; M G Davies; M E Hodson; Stephen R Durham; D Li; Peter K Jeffery; Michael J H Scallan; Robert H Balfour; Simon J Eastman; Seng Cheng; AE Smith; DP Meeker; Duncan M Geddes
Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: a double-blind placebo-controlled trial.
Lancet 1999;353(9157):947-54.
1999: Nelson S Yew; KX Wang; Malgorzata Przybylska; Rebecca G Bagley; M Stedman; John Marshall; Ronald K Scheule; Seng Cheng
Contribution of plasmid DNA to inflammation in the lung after administration of cationic lipid:pDNA complexes.
Human gene therapy 1999;10(2):223-34.
1999: Qiuming Chu; Jennifer D Tousignant; S Fang; Canwen Jiang; L H Chen; Seng Cheng; Ronald K Scheule; Simon J Eastman
Binding and uptake of cationic lipid:pDNA complexes by polarized airway epithelial cells.
Human gene therapy 1999;10(1):25-36.
1998: Canwen Jiang; S P O'Connor; SL Fang; KX Wang; John Marshall; J L Williams; B Wilburn; Yann Echelard; Seng Cheng
Efficiency of cationic lipid-mediated transfection of polarized and differentiated airway epithelial cells in vitro and in vivo.
Human gene therapy 1998;9(11):1531-42.
1998: Canwen Jiang; SL Fang; Y F Xiao; S P O'Connor; S G Nadler; D W Lee; D M Jefferson; J M Kaplan; A E Smith; Seng Cheng
Partial restoration of cAMP-stimulated CFTR chloride channel activity in DeltaF508 cells by deoxyspergualin.
The American journal of physiology 1998;275(1 Pt 1):C171-8.
1998: Johanne M Kaplan; SE Pennington; Judith A St George; LA Woodworth; A Fasbender; John Marshall; Seng Cheng; Samuel C Wadsworth; Richard J Gregory; AE Smith
Potentiation of gene transfer to the mouse lung by complexes of adenovirus vector and polycations improves therapeutic potential.
Human gene therapy 1998;9(10):1469-79.
1998: Seng Cheng; John Marshall; Ronald K Scheule; AE Smith
Cationic lipid formulations for intracellular gene delivery of cystic fibrosis transmembrane conductance regulator to airway epithelia.
Methods in enzymology 1998;292():697-717.
1998: Simon J Eastman; Jennifer D Tousignant; Michael Lukason; Qiuming Chu; Seng Cheng; Ronald K Scheule
Aerosolization of cationic lipid:pDNA complexes--in vitro optimization of nebulizer parameters for human clinical studies.
Human gene therapy 1998;9(1):43-52.
1997: Joseph Zabner; Seng Cheng; DP Meeker; Janice Launspach; Robert H Balfour; Michael A Perricone; James E Morris; John Marshall; A Fasbender; A E Smith; Michael J Welsh
Comparison of DNA-lipid complexes and DNA alone for gene transfer to cystic fibrosis airway epithelia in vivo.
The Journal of clinical investigation 1997;100(6):1529-37.
1997: Sharon Chadwick; H D Kingston; Myra Stern; R M Cook; B J O'Connor; M Lukasson; R P Balfour; M Rosenberg; Seng Cheng; AE Smith; DP Meeker; Duncan M Geddes; Eric W F W Alton
Safety of a single aerosol administration of escalating doses of the cationic lipid GL-67/DOPE/DMPE-PEG5000 formulation to the lungs of normal volunteers.
Gene therapy 1997;4(9):937-42.
1997: A Fasbender; John Marshall; Thomas O Moninger; T Grunst; Seng Cheng; Michael J Welsh
Effect of co-lipids in enhancing cationic lipid-mediated gene transfer in vitro and in vivo.
Gene therapy 1997;4(7):716-25.
1997: Simon J Eastman; Michael Lukason; Jennifer D Tousignant; H Murray; M D Lane; Judith A St George; Geoffrey Y Akita; Maribeth Cherry; Seng Cheng; Ronald K Scheule
A concentrated and stable aerosol formulation of cationic lipid:DNA complexes giving high-level gene expression in mouse lung.
Human gene therapy 1997;8(6):765-73.
1997: Ronald K Scheule; Judith A St George; Rebecca G Bagley; John Marshall; Johanne M Kaplan; Geoffrey Y Akita; KX Wang; ER Lee; DJ Harris; Canwen Jiang; Nelson S Yew; AE Smith; Seng Cheng
Basis of pulmonary toxicity associated with cationic lipid-mediated gene transfer to the mammalian lung.
Human gene therapy 1997;8(6):689-707.
1997: Canwen Jiang; Geoffrey Y Akita; W H Colledge; R A Ratcliff; Martin J Evans; K M Hehir; Judith A St George; Samuel C Wadsworth; Seng Cheng
Increased contact time improves adenovirus-mediated CFTR gene transfer to nasal epithelium of CF mice.
Human gene therapy 1997;8(6):671-80.
1997: Simon J Eastman; C Siegel; Jennifer D Tousignant; AE Smith; Seng Cheng; Ronald K Scheule
Biophysical characterization of cationic lipid: DNA complexes.
Biochimica et biophysica acta 1997;1325(1):41-62.
1997: Nelson S Yew; D M Wysokenski; KX Wang; Robin J Ziegler; John Marshall; D McNeilly; Maribeth Cherry; W Osburn; Seng Cheng
Optimization of plasmid vectors for high-level expression in lung epithelial cells.
Human gene therapy 1997;8(5):575-84.
1997: P L Felgner; Y Barenholz; J P Behr; Seng Cheng; P Cullis; L Huang; J A Jessee; L Seymour; F Szoka; Alain THIERRY; Ernst Wagner; G Wu
Nomenclature for synthetic gene delivery systems.
Human gene therapy 1997;8(5):511-2.
1997: Simon J Eastman; Jennifer D Tousignant; Michael Lukason; H Murray; C S Siegel; P Constantino; DJ Harris; Seng Cheng; Ronald K Scheule
Optimization of formulations and conditions for the aerosol delivery of functional cationic lipid:DNA complexes.
Human gene therapy 1997;8(3):313-22.
1996: C J Wheeler; Philip L Felgner; Y J Tsai; John Marshall; L Sukhu; S G Doh; Jukka Hartikka; J Nietupski; Marston Manthorpe; M Nichols; M Plewe; X Liang; Jon Norman; A Smith; Seng Cheng
A novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11454-9.
1996: Canwen Jiang; S P O'Connor; Donna Armentano; P B Berthelette; S C Schiavi; Douglas M Jefferson; AE Smith; Samuel C Wadsworth; Seng Cheng
Ability of adenovirus vectors containing different CFTR transcriptional cassettes to correct ion transport defects in CF cells.
The American journal of physiology 1996;271(4 Pt 1):L527-37.
1996: E R Lee; John Marshall; C S Siegel; Canwen Jiang; Nelson S Yew; M R Nichols; J B Nietupski; Robin J Ziegler; M B Lane; KX Wang; N C Wan; Ronald K Scheule; DJ Harris; AE Smith; Seng Cheng
Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung.
Human gene therapy 1996;7(14):1701-17.
1996: L A Schwarz; J L Johnson; M Black; Seng Cheng; M E Hogan; J Clifford Waldrep
Delivery of DNA-cationic liposome complexes by small-particle aerosol.
Human gene therapy 1996;7(6):731-41.
1996: S C Schiavi; N Abdelkader; S Reber; S Pennington; R Narayana; John M McPherson; AE Smith; H Hoppe; Seng Cheng
Biosynthetic and growth abnormalities are associated with high-level expression of CFTR in heterologous cells.
The American journal of physiology 1996;270(1 Pt 1):C341-51.
1995: Philip L Felgner; Y J Tsai; L Sukhu; C J Wheeler; Marston Manthorpe; John Marshall; Seng Cheng
Improved cationic lipid formulations for in vivo gene therapy.
Annals of the New York Academy of Sciences 1995;772():126-39.
1995: Ronald K Scheule; Rebecca G Bagley; A L Erickson; KX Wang; S L Fang; C Vaccaro; C R O'Riordan; Seng Cheng; AE Smith
Delivery of purified, functional CFTR to epithelial cells in vitro using influenza hemagglutinin.
American journal of respiratory cell and molecular biology 1995;13(3):330-43.
1995: William H Colledge; B S Abella; K W Southern; R Ratcliff; C Jiang; Seng Cheng; Lesley MacVinish; J R Anderson; Alan W Cuthbert; Martin J Evans
Generation and characterization of a delta F508 cystic fibrosis mouse model.
Nature genetics 1995;10(4):445-52.
1995: C R O'Riordan; A Erickson; C Bear; C Li; P Manavalan; KX Wang; John Marshall; Ronald K Scheule; John M McPherson; Seng Cheng
Purification and characterization of recombinant cystic fibrosis transmembrane conductance regulator from Chinese hamster ovary and insect cells.
The Journal of biological chemistry 1995;270(28):17033-43.
1995: L I Wolkoff; R D Perrone; Shelley A Grubman; D W Lee; Stephen Soltoff; L C Rogers; M Beinborn; S L Fang; Seng Cheng; Douglas M Jefferson
Purinoceptor P2U identification and function in human intrahepatic biliary epithelial cell lines.
Cell calcium 1995;17(5):375-83.
1995: Seng Cheng; S L Fang; Joseph Zabner; John Marshall; S Piraino; S C Schiavi; Douglas M Jefferson; Michael J Welsh; AE Smith
Functional activation of the cystic fibrosis trafficking mutant delta F508-CFTR by overexpression.
The American journal of physiology 1995;268(4 Pt 1):L615-24.
1995: Shelley A Grubman; S L Fang; Andrew E Mulberg; R D Perrone; L C Rogers; D W Lee; D Armentano; S L Murray; H L Dorkin; Seng Cheng
Correction of the cystic fibrosis defect by gene complementation in human intrahepatic biliary epithelial cell lines.
Gastroenterology 1995;108(2):584-92.
1994: Herbert A Berger; D P Rich; Seng Cheng; Sue M Travis; M Saxena; AE Smith; Michael J Welsh
Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by negative charge in the R domain.
The Japanese journal of physiology 1994;44 Suppl 2():S167-72.
1993: T Shinohara; M Matsuda; Seng Cheng; J Marshall; M Fujita; K Nagashima
BK virus infection of the human urinary tract.
Journal of medical virology 1993;41(4):301-5.
1993: D P Rich; Herbert A Berger; Seng Cheng; Sue M Travis; M Saxena; AE Smith; Michael J Welsh
Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by negative charge in the R domain.
The Journal of biological chemistry 1993;268(27):20259-67.
1993: D P Rich; Richard J Gregory; Seng Cheng; AE Smith; Michael J Welsh
Effect of deletion mutations on the function of CFTR chloride channels.
Receptors & channels 1993;1(3):221-32.
1992: J F Amara; Seng Cheng; A E Smith
Intracellular protein trafficking defects in human disease.
Trends in cell biology 1992;2(5):145-9.
1992: Michael J Welsh; Matthew Peter Anderson; D P Rich; Herbert A Berger; Gerene M Denning; Lynda S Ostedgaard; D N Sheppard; Seng Cheng; Richard J Gregory; AE Smith
Cystic fibrosis transmembrane conductance regulator: a chloride channel with novel regulation.
Neuron 1992;8(5):821-9.
1992: P C Espino; W Y Chou; A E Smith; Seng Cheng
The amino-terminal half of pp59c-fyn contains sequences necessary for formation of a 75 kDa form and also repressive elements absent in pp60c-src.
Oncogene 1992;7(2):317-22.
1992: P DiTullio; Seng Cheng; J Marshall; R J Gregory; K M Ebert; Harry M Meade; A E Smith
Production of cystic fibrosis transmembrane conductance regulator in the milk of transgenic mice.
Bio/technology (Nature Publishing Company) 1992;10(1):74-7.
1992: Gerene M Denning; Lynda S Ostedgaard; Seng Cheng; AE Smith; Michael J Welsh
Localization of cystic fibrosis transmembrane conductance regulator in chloride secretory epithelia.
The Journal of clinical investigation 1992;89(1):339-49.
1991: E Marsilio; Seng Cheng; B Schaffhausen; E Paucha; David M Livingston
The T/t common region of simian virus 40 large T antigen contains a distinct transformation-governing sequence.
Journal of virology 1991;65(10):5647-52.
1991: Seng Cheng; D P Rich; John Marshall; Richard J Gregory; Michael J Welsh; AE Smith
Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel.
Cell 1991;66(5):1027-36.
1991: J Marshall; A E Smith; Seng Cheng
Monoclonal antibody specific for BK virus large-T antigen allows discrimination among the different papovaviral large-T antigens.
Oncogene 1991;6(9):1673-6.
1991: Richard J Gregory; D P Rich; Seng Cheng; D W Souza; S Paul; P Manavalan; Matthew Peter Anderson; Michael J Welsh; AE Smith
Maturation and function of cystic fibrosis transmembrane conductance regulator variants bearing mutations in putative nucleotide-binding domains 1 and 2.
Molecular and cellular biology 1991;11(8):3886-93.
1991: Seng Cheng; P C Espino; J Marshall; R Harvey; J Merrill; A E Smith
Structural elements that regulate pp59c-fyn catalytic activity, transforming potential, and ability to associate with polyomavirus middle-T antigen.
Journal of virology 1991;65(1):170-9.
1990: Seng Cheng; Richard J Gregory; John Marshall; S Paul; D W Souza; G A White; C R O'Riordan; AE Smith
Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis.
Cell 1990;63(4):827-34.
1990: Seng Cheng; P C Espino; J Marshall; R Harvey; A E Smith
Stoichiometry of cellular and viral components in the polyomavirus middle-T antigen-tyrosine kinase complex.
Molecular and cellular biology 1990;10(10):5569-74.
1990: Richard J Gregory; Seng Cheng; D P Rich; John Marshall; S Paul; K Hehir; Lynda S Ostedgaard; K W Klinger; Michael J Welsh; AE Smith
Expression and characterization of the cystic fibrosis transmembrane conductance regulator.
Nature 1990;347(6291):382-6.
1990: D P Rich; Matthew Peter Anderson; Richard J Gregory; Seng Cheng; S Paul; Douglas M Jefferson; J D McCann; K W Klinger; AE Smith; Michael J Welsh
Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells.
Nature 1990;347(6291):358-63.
1990: Sally Kornbluth; Seng Cheng; W Markland; Y Fukui; Hidesaburo Hanafusa
Association of p62c-yes with polyomavirus middle T-antigen mutants correlates with transforming ability.
Journal of virology 1990;64(4):1584-9.
1990: P C Espino; R Harvey; R L Schweickhardt; G A White; A E Smith; Seng Cheng
The amino-terminal region of pp60c-src has a modulatory role and contains multiple sites of tyrosine phosphorylation.
Oncogene 1990;5(3):283-93.
1990: H Piwnica-Worms; N G Williams; Seng Cheng; Thomas M Roberts
Regulation of pp60c-src and its interaction with polyomavirus middle T antigen in insect cells.
Journal of virology 1990;64(1):61-8.
1989: R Harvey; K M Hehir; A E Smith; Seng Cheng
pp60c-src variants containing lesions that affect phosphorylation at tyrosines 416 and 527.
Molecular and cellular biology 1989;9(9):3647-56.
1989: Mark E Ewen; J W Ludlow; E Marsilio; James A DeCaprio; Robert C Millikan; Seng Cheng; E Paucha; David M Livingston
An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110Rb and a second cellular protein, p120.
Cell 1989;58(2):257-67.
1988: Seng Cheng; R Harvey; P C Espino; K Semba; T Yamamoto; K Toyoshima; A E Smith
Peptide antibodies to the human c-fyn gene product demonstrate pp59c-fyn is capable of complex formation with the middle-T antigen of polyomavirus.
The EMBO journal 1988;7(12):3845-55.
1988: Seng Cheng; H Piwnica-Worms; R W Harvey; Thomas M Roberts; A E Smith
The carboxy terminus of pp60c-src is a regulatory domain and is involved in complex formation with the middle-T antigen of polyomavirus.
Molecular and cellular biology 1988;8(4):1736-47.
1987: H Piwnica-Worms; K B Saunders; Thomas M Roberts; A E Smith; Seng Cheng
Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src.
Cell 1987;49(1):75-82.
1986: W Markland; Seng Cheng; B A Oostra; A E Smith
In vitro mutagenesis of the putative membrane-binding domain of polyomavirus middle-T antigen.
Journal of virology 1986;59(1):82-9.
1986: Seng Cheng; W Markland; A F Markham; A E Smith
Mutations around the NG59 lesion indicate an active association of polyoma virus middle-T antigen with pp60c-src is required for cell transformation.
The EMBO journal 1986;5(2):325-34.
1986: Seng Cheng; S Malcolm; S Pemble; B Winchester
Purification and comparison of the structures of human liver acidic alpha-D-mannosidases A and B.
The Biochemical journal 1986;233(1):65-72.
1983: R Pohlmann; A Hasilik; Seng Cheng; S Pemble; B Winchester; K von Figura
Synthesis of lysosomal alpha-mannosidase in normal and mannosidosis fibroblasts.
Biochemical and biophysical research communications 1983;115(3):1083-9.