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David Spence

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J David Spence
Clinical clues to paradoxical embolism.
J David Spence; David J A Jenkins; Jean Davignon
Dietary cholesterol and egg yolks: not for patients at risk of vascular disease.
Robert Clarke; Jim Halsey; Sarah Lewington; Eva Lonn; Jane Armitage; JoAnn E Manson; Kaare H Bønaa; J David Spence; Ottar Nygård; Rex Jamison; J Michael Gaziano; Peter Guarino; Derrick Bennett; Fraz Mir; Richard Peto; Rory Collins
Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals.

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All Publications

2010: J David Spence
Clinical clues to paradoxical embolism.
International journal of stroke : official journal of the International Stroke Society 2010;5(6):514; author reply 514.
2010: J David Spence; David J A Jenkins; Jean Davignon
Dietary cholesterol and egg yolks: not for patients at risk of vascular disease.
The Canadian journal of cardiology 2010;26(9):e336-9.
2010: Robert Clarke; Jim Halsey; Sarah Lewington; Eva Lonn; Jane Armitage; JoAnn E Manson; Kaare H Bønaa; J David Spence; Ottar Nygård; Rex Jamison; J Michael Gaziano; Peter Guarino; Derrick Bennett; Fraz Mir; Richard Peto; Rory Collins
Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals.
Archives of internal medicine 2010;170(18):1622-31.
2010: J David Spence
Secondary stroke prevention.
Nature reviews. Neurology 2010;6(9):477-86.
2010: J David Spence
Cerebrovascular disease: Identifying high-risk patients from carotid plaque composition.
Nature reviews. Cardiology 2010;7(8):426-8.
2010: J David Spence; Daniel G Hackam
Treating arteries instead of risk factors: a paradigm change in management of atherosclerosis.
Stroke; a journal of cerebral circulation 2010;41(6):1193-9.
2010: J David Spence
Asymptomatic carotid stenosis: mainly a medical condition.
Vascular 2010;18(3):123-6; discussion 127-9.
2010: Andrew A House; Michael Eliasziw; Daniel C Cattran; David N Churchill; Matthew J Oliver; Adrian Fine; George K Dresser; J David Spence
Effect of B-vitamin therapy on progression of diabetic nephropathy: a randomized controlled trial.
JAMA : the journal of the American Medical Association 2010;303(16):1603-9.
2010: Iris Shai; J David Spence; Dan Schwarzfuchs; Yaakov Henkin; Grace Parraga; Assaf Rudich; Aaron Fenster; Christiane Mallett; Noah Liel-Cohen; Amir Tirosh; Arkady Bolotin; Joachim Thiery; Georg Martin Fiedler; Matthias Blüher; Michael Stumvoll; Meir J Stampfer
Dietary intervention to reverse carotid atherosclerosis.
Circulation 2010;121(10):1200-8.
2010: J David Spence; Victoria Coates; Hector Li; Arturo Tamayo; Claudio Muñoz; Daniel G Hackam; Maria DiCicco; Janine DesRoches; Chrysi Bogiatzi; Jonathan Klein; Joaquim Madrenas; Robert A Hegele
Effects of intensive medical therapy on microemboli and cardiovascular risk in asymptomatic carotid stenosis.
Archives of neurology 2010;67(2):180-6.
2010: Michel Romanens; Franz Ackermann; J David Spence; Roger Darioli; Nicolas Rodondi; Roberto Corti; Georg Noll; Matthias Schwenkglenks; Michael Pencina
Improvement of cardiovascular risk prediction: time to review current knowledge, debates, and fundamentals on how to assess test characteristics.
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 2010;17(1):18-23.
2010: J David Spence
Is there a role for revascularisation in asymptomatic carotid stenosis? No.
BMJ (Clinical research ed.) 2010;341():c4900.
2010: Bernard Chiu; Adam Krasinski; J David Spence; Grace Parraga; Aaron Fenster
Three-dimensional carotid ultrasound segmentation variability dependence on signal difference and boundary orientation.
Ultrasound in medicine & biology 2010;36(1):95-110.
2009: Adam Krasinski; Bernard Chiu; J David Spence; Aaron Fenster; Grace Parraga
Three-dimensional ultrasound quantification of intensive statin treatment of carotid atherosclerosis.
Ultrasound in medicine & biology 2009;35(11):1763-72.
2009: J David Spence
Treating hypertension in acute ischemic stroke.
Hypertension 2009;54(4):702-3.
2009: J David Spence
Stroke: Atrial fibrillation, stroke prevention therapy and aging.
Nature reviews. Cardiology 2009;6(7):448-50.
2009: J David Spence
Asymptomatic carotid stenosis: criterion standard should be medical therapy.
Archives of surgery (Chicago, Ill. : 1960) 2009;144(4):382-3.
2009: Bernard Chiu; Vadim Beletsky; J David Spence; Grace Parraga; Aaron Fenster
Analysis of carotid lumen surface morphology using three-dimensional ultrasound imaging.
Physics in medicine and biology 2009;54(5):1149-67.
2009: Christiane Mallett; Andrew A House; J David Spence; Aaron Fenster; Grace Parraga
Longitudinal ultrasound evaluation of carotid atherosclerosis in one, two and three dimensions.
Ultrasound in medicine & biology 2009;35(3):367-75.
2009: Nuwan D Nanayakkara; Bernard Chiu; Abbas Samani; J David Spence; Jagath Samarabandu; Grace Parraga; Aaron Fenster
Nonrigid registration of three-dimensional ultrasound and magnetic resonance images of the carotid arteries.
Medical physics 2009;36(2):373-85.
2009: Sankalp Bhavsar; Andre Nimigan; Daniel G Hackam; David B O'Gorman; Bing Siang Gan; J David Spence
Keloid scarring, but not Dupuytren's contracture, is associated with unexplained carotid atherosclerosis.
Clinical and investigative medicine. Médecine clinique et experimentale 2009;32(2):E95-102.
2009: Murray Cutler; Bradley L Urquhart; David J Freeman; J David Spence; Andrew A House
Mesna for the treatment of hyperhomocysteinemia in hemodialysis patients.
Blood purification 2009;27(3):306-10.
2008: A Ozcan Ozdemir; Arturo Tamayo; Claudio Munoz; Bryan Dias; J David Spence
Cryptogenic stroke and patent foramen ovale: clinical clues to paradoxical embolism.
Journal of the neurological sciences 2008;275(1-2):121-7.
2008: Arvin Vidal; Yves Bureau; Trevor Wade; J David Spence; Brian K Rutt; Aaron Fenster; Grace Parraga
Scan-rescan and intra-observer variability of magnetic resonance imaging of carotid atherosclerosis at 1.5 T and 3.0 T.
Physics in medicine and biology 2008;53(23):6821-35.
2008: J David Spence
Is carotid intima-media thickness a reliable clinical predictor?
Mayo Clinic proceedings. Mayo Clinic 2008;83(11):1299-300; author reply 1300-1.
2008: Nuwan D Nanayakkara; Bernard Chiu; Abbas Samani; J David Spence; Jagath Samarabandu; Aaron Fenster
A "twisting and bending" model-based nonrigid image registration technique for 3-D ultrasound carotid images.
IEEE transactions on medical imaging 2008;27(10):1378-88.
2008: Jonathan H Klein; Robert A Hegele; Daniel G Hackam; Marlys L Koschinsky; Murray W Huff; J David Spence
Lipoprotein(a) is associated differentially with carotid stenosis, occlusion, and total plaque area.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(10):1851-6.
2008: Daniel G Hackam; Minh L Duong-Hua; Muhammad Mamdani; Ping Li; Sheldon W Tobe; J David Spence; Amit X Garg
Angiotensin inhibition in renovascular disease: a population-based cohort study.
American heart journal 2008;156(3):549-55.
2008: O Ozdemir; Miguel Bussière; A Leung; Irene Gulka; D Lee; R Chan; J David Spence; David M Pelz
Intra-arterial thrombolysis of occluded middle cerebral artery by use of collateral pathways in patients with tandem cervical carotid artery/middle cerebral artery occlusion.
AJNR. American journal of neuroradiology 2008;29(8):1596-600.
2008: Bernard Chiu; Micaela Egger; J David Spence; Grace Parraga; Aaron Fenster
Quantification of carotid vessel wall and plaque thickness change using 3D ultrasound images.
Medical physics 2008;35(8):3691-710.
2008: Sang-Wook Lee; Luca Antiga; J David Spence; David A Steinman
Geometry of the carotid bifurcation predicts its exposure to disturbed flow.
Stroke; a journal of cerebral circulation 2008;39(8):2341-7.
2008: Bradley L Urquhart; David J Freeman; Murray Cutler; Rahul Mainra; J David Spence; Andrew A House
Mesna for treatment of hyperhomocysteinemia in hemodialysis patients: a placebo-controlled, double-blind, randomized trial.
Clinical journal of the American Society of Nephrology : CJASN 2008;3(4):1041-7.
2008: Ozcan Ozdemir; Vadim Beletsky; vladimir hachinski; J David Spence
Cerebrovascular events on awakening, patent foramen ovale and obstructive sleep apnea syndrome.
Journal of the neurological sciences 2008;268(1-2):193-4.
2008: J David Spence
Polypill: for Pollyanna.
International journal of stroke : official journal of the International Stroke Society 2008;3(2):92-7.
2008: J David Spence
White-coat hypertension is hypertension.
Hypertension 2008;51(5):1272.
2008: Micaela Egger; Bernard Chiu; J David Spence; Aaron Fenster; Grace Parraga
Mapping spatial and temporal changes in carotid atherosclerosis from three-dimensional ultrasound images.
Ultrasound in medicine & biology 2008;34(1):64-72.
2007: Daniel G Hackam; J David Spence; Amit X Garg; Stephen C Textor
Role of renin-angiotensin system blockade in atherosclerotic renal artery stenosis and renovascular hypertension.
Hypertension 2007;50(6):998-1003.
2007: J David Spence
Homocysteine-lowering therapy: a role in stroke prevention?
Lancet neurology 2007;6(9):830-8.
2007: Bradley L Urquhart; David J Freeman; J David Spence; Andrew A House
Mesna as a nonvitamin intervention to lower plasma total homocysteine concentration: implications for assessment of the homocysteine theory of atherosclerosis.
Journal of clinical pharmacology 2007;47(8):991-7.
2007: J David Spence
New treatment options for hypertension during acute ischemic or hemorrhagic stroke.
Current treatment options in cardiovascular medicine 2007;9(3):242-6.
2007: Micaela Egger; J David Spence; Aaron Fenster; Grace Parraga
Validation of 3D ultrasound vessel wall volume: an imaging phenotype of carotid atherosclerosis.
Ultrasound in medicine & biology 2007;33(6):905-14.
2007: Daniel G Hackam; J David Spence
Combining multiple approaches for the secondary prevention of vascular events after stroke: a quantitative modeling study.
Stroke; a journal of cerebral circulation 2007;38(6):1881-5.
2007: Anthony Landry; Craig Ainsworth; Christopher Blake; J David Spence; Aaron Fenster
Manual planimetric measurement of carotid plaque volume using three-dimensional ultrasound imaging.
Medical physics 2007;34(4):1496-505.
2007: J David Spence
Perspective on the efficacy analysis of the Vitamin Intervention for Stroke Prevention trial.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2007;45(12):1582-5.
2007: J David Spence
Intensive management of risk factors for accelerated atherosclerosis: the role of multiple interventions.
Current neurology and neuroscience reports 2007;7(1):42-8.
2007: Bradley L Urquhart; David J Freeman; J David Spence; Andrew A House
The effect of mesna on plasma total homocysteine concentration in hemodialysis patients.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2007;49(1):109-17.
2006: Aaron Fenster; Christopher Blake; Igor Gyacskov; Anthony Landry; J David Spence
3D ultrasound analysis of carotid plaque volume and surface morphology.
Ultrasonics 2006;44 Suppl 1():e153-7.
2006: J David Spence
Homocysteine and stroke prevention: have the trials settled the issue?
International journal of stroke : official journal of the International Stroke Society 2006;1(4):242-4.
2006: J David Spence
Measurement of intima-media thickness vs. carotid plaque: uses in patient care, genetic research and evaluation of new therapies.
International journal of stroke : official journal of the International Stroke Society 2006;1(4):216-21.
2006: J David Spence
Technology Insight: ultrasound measurement of carotid plaque--patient management, genetic research, and therapy evaluation.
Nature clinical practice. Neurology 2006;2(11):611-9.
2006: J David Spence
Nutrition and stroke prevention.
Stroke; a journal of cerebral circulation 2006;37(9):2430-5.
2006: Bradley L Urquhart; Andrew A House; Murray Cutler; J David Spence; David J Freeman
Thiol exchange: an in vitro assay that predicts the efficacy of novel homocysteine lowering therapies.
Journal of pharmaceutical sciences 2006;95(8):1742-50.
2006: J David Spence
Treating hypertension in acute stroke: a better arrow for the quiver.
Hypertension 2006;47(6):1051.
2006: J David Spence
Lipoprotein(a): involved in events, but not burden of atherosclerotic disease?
Stroke; a journal of cerebral circulation 2006;37(6):1350-1.
2006: Bernard Chiu; Micaela Egger; J David Spence; Grace Parraga; Aaron Fenster
Quantification of progression and regression of carotid vessel atherosclerosis using 3D ultrasound images.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2006;1():3819-22.
2006: Silvia A Riccio; Andrew A House; J David Spence; Aaron Fenster; Grace Parraga
Carotid ultrasound phenotypes in vulnerable populations.
Cardiovascular ultrasound 2006;4():44.
2006: Rebecca L Pollex; Khalid Z Al-Shali; Andrew A House; J David Spence; Aaron Fenster; Mary Mamakeesick; Bernard Zinman; Stewart B Harris; Anthony J G Hanley; Robert A Hegele
Relationship of the metabolic syndrome to carotid ultrasound traits.
Cardiovascular ultrasound 2006;4():28.
2005: Robert A Hegele; Khalid Z Al-Shali; Andrew A House; Anthony J G Hanley; Stewart B Harris; Mary Mamakeesick; Aaron Fenster; Bernard Zinman; Henian Cao; J David Spence
Disparate associations of a functional promoter polymorphism in PCK1 with carotid wall ultrasound traits.
Stroke; a journal of cerebral circulation 2005;36(12):2566-70.
2005: J David Spence; Heejung Bang; Lloyd E Chambless; Meir J Stampfer
Vitamin Intervention For Stroke Prevention trial: an efficacy analysis.
Stroke; a journal of cerebral circulation 2005;36(11):2404-9.
2005: Jonathan B Thomas; Luca Antiga; Susan L Che; Jaques S Milner; David A Steinman; J David Spence; Brian K Rutt; David A Steinman
Variation in the carotid bifurcation geometry of young versus older adults: implications for geometric risk of atherosclerosis.
Stroke; a journal of cerebral circulation 2005;36(11):2450-6.
2005: J David Spence; Arturo Tamayo; Stephen P Lownie; Wai P Ng; Gary G Ferguson
Absence of microemboli on transcranial Doppler identifies low-risk patients with asymptomatic carotid stenosis.
Stroke; a journal of cerebral circulation 2005;36(11):2373-8.
2005: Craig D Ainsworth; Christopher C Blake; Arturo Tamayo; Vadim Beletsky; Aaron Fenster; J David Spence
3D ultrasound measurement of change in carotid plaque volume: a tool for rapid evaluation of new therapies.
Stroke; a journal of cerebral circulation 2005;36(9):1904-9.
2005: Anthony J G Hanley; Stewart B Harris; Mary Mamakeesick; Ken Goodwin; Edith Fiddler; Robert A Hegele; J David Spence; Andrew A House; Ed Brown; Blair Schoales; John R McLaughlin; Ronald Klein; Bernard Zinman
Complications of Type 2 Diabetes Among Aboriginal Canadians: prevalence and associated risk factors.
Diabetes care 2005;28(8):2054-7.
2005: Julie Robertson; Francesco Iemolo; Sally P Stabler; Robert H Allen; J David Spence
Vitamin B12, homocysteine and carotid plaque in the era of folic acid fortification of enriched cereal grain products.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2005;172(12):1569-73.
2005: Anthony Landry; J David Spence; Aaron Fenster
Quantification of carotid plaque volume measurements using 3D ultrasound imaging.
Ultrasound in medicine & biology 2005;31(6):751-62.
2005: Jonathan B Thomas; Lisa Jong; J David Spence; Bruce A Wasserman; Brian K Rutt; David A Steinman
Anthropometric data for magnetic resonance imaging of the carotid bifurcation.
Journal of magnetic resonance imaging : JMRI 2005;21(6):845-9.
2005: Max K Kole; David M Pelz; Donald H Lee; Vivek Jain; J David Spence; Stephen P Lownie
Intra-arterial thrombolysis of embolic middle cerebral artery using collateral pathways.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2005;32(2):257-60.
2005: Khalid Z Al-Shali; Andrew A House; Anthony J G Hanley; Hafiz M R Khan; Stewart B Harris; Mary Mamakeesick; Bernard Zinman; Aaron Fenster; J David Spence; Robert A Hegele
Differences between carotid wall morphological phenotypes measured by ultrasound in one, two and three dimensions.
Atherosclerosis 2005;178(2):319-25.
2005: Rebecca L Pollex; J David Spence; Andrew A House; Aaron Fenster; Anthony J G Hanley; Bernard Zinman; Stewart B Harris; Robert A Hegele
A comparison of ultrasound measurements to assess carotid atherosclerosis development in subjects with and without type 2 diabetes.
Cardiovascular ultrasound 2005;3():15.
2005: J David Spence
Point: uses of carotid plaque measurement as a predictor of cardiovascular events.
Preventive cardiology 2005;8(2):118-21; discussion 126.
2004: David G Bailey; J Malcolm; O Arnold; J David Spence
Grapefruit juice-drug interactions. 1998.
British journal of clinical pharmacology 2004;58(7):S831-40; discussion S841-3.
2004: J David Spence; Robert A Hegele
Noninvasive phenotypes of atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(11):e188; author reply e188-9.
2004: Andrew A House; Michael Eliasziw; Bradley L Urquhart; David J Freeman; J David Spence
Dimercaptosuccinic acid for the treatment of hyperhomocysteinemia in hemodialysis patients: a placebo-controlled, double-blind, randomized trial.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2004;44(4):689-94.
2004: Khalid Z Al-Shali; Andrew A House; Anthony J G Hanley; Hafiz M R Khan; Stewart B Harris; Bernard Zinman; Mary Mamakeesick; Aaron Fenster; J David Spence; Robert A Hegele
Genetic variation in PPARG encoding peroxisome proliferator-activated receptor gamma associated with carotid atherosclerosis.
Stroke; a journal of cerebral circulation 2004;35(9):2036-40.
2004: Aaron Fenster; Anthony Landry; Donal B Downey; Robert A Hegele; J David Spence
3D ultrasound imaging of the carotid arteries.
Current drug targets. Cardiovascular & haematological disorders 2004;4(2):161-75.
2004: J David Spence; Robert A Hegele
Non-invasive assessment of atherosclerosis risk.
Current drug targets. Cardiovascular & haematological disorders 2004;4(2):125-8.
2004: Anthony Landry; J David Spence; Aaron Fenster
Measurement of carotid plaque volume by 3-dimensional ultrasound.
Stroke; a journal of cerebral circulation 2004;35(4):864-9.
2004: J David Spence; Robert A Hegele
Noninvasive phenotypes of atherosclerosis: similar windows but different views.
Stroke; a journal of cerebral circulation 2004;35(3):649-53.
2004: James F Toole; M Rene Malinow; Lloyd E Chambless; J David Spence; L Creed Pettigrew; Virginia J Howard; Elizabeth G Sides; Chin-Hua Wang; Meir Stampfer
Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial.
JAMA : the journal of the American Medical Association 2004;291(5):565-75.
2004: Francesco Iemolo; Alexandra Martiniuk; David A Steinman; J David Spence
Sex differences in carotid plaque and stenosis.
Stroke; a journal of cerebral circulation 2004;35(2):477-81.
2003: J David Spence; Tanya Thornton; Alister D Muir; Neil D Westcott
The effect of flax seed cultivars with differing content of alpha-linolenic acid and lignans on responses to mental stress.
Journal of the American College of Nutrition 2003;22(6):494-501.
2003: Michel Beaudry; J David Spence
Motor vehicle accidents: the most common cause of traumatic vertebrobasilar ischemia.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2003;30(4):320-5.
2003: J David Spence; Christopher Blake; Anthony Landry; Aaron Fenster
Measurement of carotid plaque and effect of vitamin therapy for total homocysteine.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2003;41(11):1498-504.
2003: J David Spence
Fasting lipids: the carrot in the snowman.
The Canadian journal of cardiology 2003;19(8):890-2.
2003: J David Spence; Matthew R Ban; Robert A Hegele
Lipoprotein lipase (LPL) gene variation and progression of carotid artery plaque.
Stroke; a journal of cerebral circulation 2003;34(5):1176-80.
2003: J David Spence; John Norris
Infection, inflammation, and atherosclerosis.
Stroke; a journal of cerebral circulation 2003;34(2):333-4.
2003: J David Spence
Nutritional and metabolic aspects of stroke prevention.
Advances in neurology 2003;92():173-8.
2002: J David Spence; Michael Eliasziw; Maria DiCicco; Daniel G Hackam; Ramzy Galil; Tara Lohmann
Carotid plaque area: a tool for targeting and evaluating vascular preventive therapy.
Stroke; a journal of cerebral circulation 2002;33(12):2916-22.
2002: J David Spence; Arturo Tamayo; Maria DiCicco
Unstable carotid plaque.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2002;166(9):1189.
2002: J David Spence
Treatment options for renovascular hypertension.
Expert opinion on pharmacotherapy 2002;3(4):411-6.
2002: J David Spence
Ultrasound measurement of carotid plaque as a surrogate outcome for coronary artery disease.
The American journal of cardiology 2002;89(4A):10B-15B; discussion 15B-16B.
2002: David A Steinman; Jonathan B Thomas; Hanif M Ladak; Jaques S Milner; Brian K Rutt; J David Spence
Reconstruction of carotid bifurcation hemodynamics and wall thickness using computational fluid dynamics and MRI.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2002;47(1):149-59.
2001: Neal H Badner; D Freeman; J David Spence
Preoperative oral B vitamins prevent nitrous oxide-induced postoperative plasma homocysteine increases.
Anesthesia and analgesia 2001;93(6):1507-10, table of contents.
2001: Brian Silver; Bart M Demaerschalk; José G Merino; Edward Wong; Arturo Tamayo; A Devasenapathy; C O'Callaghan; Andrew Kertesz; G Bryan Young; A J Fox; J David Spence; vladimir hachinski
Improved outcomes in stroke thrombolysis with pre-specified imaging criteria.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2001;28(2):113-9.
2001: Daniel G Hackam; Lisa M F Thain; A Abassakoor; F N McKenzie; J David Spence
Trapped renal arteries: functional renal artery stenosis due to occlusion of the aorta in the arch and below the kidneys.
The Canadian journal of cardiology 2001;17(5):587-92.
2001: J David Spence
Patients with atherosclerotic vascular disease: how low should plasma homocyst(e)ine levels go?
American journal of cardiovascular drugs : drugs, devices, and other interventions 2001;1(2):85-9.
2000: B J Pearson; Philip Bath; J David Spence
Hypertension in patients presenting with stroke.
Current hypertension reports 2000;2(6):551-7.
2000: Elzbieta M Kurowska; J David Spence; J Jordan; Stephen Wetmore; David J Freeman; LA Piché; P Serratore
HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia.
The American journal of clinical nutrition 2000;72(5):1095-100.
2000: Neal H Badner; W Scott Beattie; D Freeman; J David Spence
Nitrous oxide-induced increased homocysteine concentrations are associated with increased postoperative myocardial ischemia in patients undergoing carotid endarterectomy.
Anesthesia and analgesia 2000;91(5):1073-9.
2000: J David Spence
Management of resistant hypertension in patients with carotid stenosis: high prevalence of renovascular hypertension.
Cerebrovascular diseases (Basel, Switzerland) 2000;10(4):249-54.
2000: D G Hackam; J C Peterson; J David Spence
What level of plasma homocyst(e)ine should be treated? Effects of vitamin therapy on progression of carotid atherosclerosis in patients with homocyst(e)ine levels above and below 14 micromol/L.
American journal of hypertension 2000;13(1 Pt 1):105-10.
2000: George K Dresser; J David Spence; David G Bailey
Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition.
Clinical pharmacokinetics 2000;38(1):41-57.
1999: J David Spence
Physiologic tailoring of therapy for resistant hypertension: 20 years' experience with stimulated renin profiling.
American journal of hypertension 1999;12(11 Pt 1):1077-83.
1999: D Wayne Taylor; Henry J M Barnett; R Brian Haynes; Gary G Ferguson; D L Sackett; Kevin E Thorpe; Denis Simard; Frank L Silver; vladimir hachinski; G P Clagett; R Barnes; J David Spence
Low-dose and high-dose acetylsalicylic acid for patients undergoing carotid endarterectomy: a randomised controlled trial. ASA and Carotid Endarterectomy (ACE) Trial Collaborators.
Lancet 1999;353(9171):2179-84.
1999: J David Spence; P A Barnett; D E Bulman; Robert A Hegele
An approach to ascertain probands with a non-traditional risk factor for carotid atherosclerosis.
Atherosclerosis 1999;144(2):429-34.
1999: J David Spence; PA Barnett; W Linden; V Ramsden; P Taenzer
Lifestyle modifications to prevent and control hypertension. 7. Recommendations on stress management. Canadian Hypertension Society, Canadian Coalition for High Blood Pressure Prevention and Control, Laboratory Centre for Disease Control at Health Canada, Heart and Stroke Foundation of Canada.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 1999;160(9 Suppl):S46-50.
1999: J David Spence; M R Malinow; PA Barnett; A J Marian; D Freeman; Robert A Hegele
Plasma homocyst(e)ine concentration, but not MTHFR genotype, is associated with variation in carotid plaque area.
Stroke; a journal of cerebral circulation 1999;30(5):969-73.
1999: Ross D Feldman; Norman Campbell; Pierre Larochelle; Peter Bolli; Ellen Burgess; SG Carruthers; J S Floras; R Brian Haynes; George Honos; Frans Leenen; L A Leiter; A G Logan; Martin G Myers; J David Spence; Kelly B Zarnke
1999 Canadian recommendations for the management of hypertension. Task Force for the Development of the 1999 Canadian Recommendations for the Management of Hypertension.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 1999;161 Suppl 12():S1-17.
1998: Henry J M Barnett; D W Taylor; Michael Eliasziw; AJ Fox; Gary G Ferguson; R Brian Haynes; R N Rankin; G P Clagett; vladimir hachinski; D L Sackett; K E Thorpe; Heather Meldrum; J David Spence
Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators.
The New England journal of medicine 1998;339(20):1415-25.
1998: Neal H Badner; K Drader; D Freeman; J David Spence
The use of intraoperative nitrous oxide leads to postoperative increases in plasma homocysteine.
Anesthesia and analgesia 1998;87(3):711-3.
1998: David G Bailey; J Malcolm; O Arnold; J David Spence
Grapefruit juice-drug interactions.
British journal of clinical pharmacology 1998;46(2):101-10.
1998: J C Peterson; J David Spence
Vitamins and progression of atherosclerosis in hyper-homocyst(e)inaemia.
Lancet 1998;351(9098):263.
1998: M Eliasziw; J David Spence; Henry J M Barnett
Carotid endarterectomy does not affect long-term blood pressure: observations from the NASCET. North American Symptomatic Carotid Endarterectomy Trial.
Cerebrovascular diseases (Basel, Switzerland) 1998;8(1):20-4.
1997: Elzbieta M Kurowska; J Jordan; J David Spence; Stephen Wetmore; LA Piché; M Radzikowski; P Dandona; KK Carroll
Effects of substituting dietary soybean protein and oil for milk protein and fat in subjects with hypercholesterolemia.
Clinical and investigative medicine. Médecine clinique et experimentale 1997;20(3):162-70.
1997: S E Rau; John R Bend; M O Arnold; L T Tran; J David Spence; David G Bailey
Grapefruit juice-terfenadine single-dose interaction: magnitude, mechanism, and relevance.
Clinical pharmacology and therapeutics 1997;61(4):401-9.
1997: J David Spence
Drug interactions with grapefruit: whose responsibility is it to warn the public?
Clinical pharmacology and therapeutics 1997;61(4):395-400.
1997: PA Barnett; J David Spence; S B Manuck; J R Jennings
Psychological stress and the progression of carotid artery disease.
Journal of hypertension 1997;15(1):49-55.
1996: J David Spence
Cerebral consequences of hypertension: where do they lead?
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1996;14(5):S139-45.
1996: David G Bailey; John R Bend; J M Arnold; L T Tran; J David Spence
Erythromycin-felodipine interaction: magnitude, mechanism, and comparison with grapefruit juice.
Clinical pharmacology and therapeutics 1996;60(1):25-33.
1996: vladimir hachinski; Carmelo Graffagnino; M Beaudry; G Bernier; C Buck; A Donner; J David Spence; G Doig; B M Wolfe
Lipids and stroke: a paradox resolved.
Archives of neurology 1996;53(4):303-8.
1995: J David Spence; M W Huff; P Heidenheim; A Viswanatha; C Munoz; R Lindsay; B Wolfe; D Mills
Combination therapy with colestipol and psyllium mucilloid in patients with hyperlipidemia.
Annals of internal medicine 1995;123(7):493-9.
1995: David G Bailey; J M Arnold; John R Bend; L T Tran; J David Spence
Grapefruit juice-felodipine interaction: reproducibility and characterization with the extended release drug formulation.
British journal of clinical pharmacology 1995;40(2):135-40.
1995: Michael Eliasziw; J Y Streifler; J David Spence; Allan J Fox; vladimir hachinski; Henry J M Barnett
Prognosis for patients following a transient ischemic attack with and without a cerebral infarction on brain CT. North American Symptomatic Carotid Endarterectomy Trial (NASCET) Group.
Neurology 1995;45(3 Pt 1):428-31.
1994: J David Spence
Effects of antihypertensive drugs on flow disturbances: nifedipine, captopril, and metoprolol evaluated by quantitative spectral analysis of Doppler flow patterns in patients with carotid stenosis.
Clinical and investigative medicine. Médecine clinique et experimentale 1994;17(4):319-25.
1994: David G Bailey; J M Arnold; J David Spence
Grapefruit juice and drugs. How significant is the interaction?
Clinical pharmacokinetics 1994;26(2):91-8.
1993: David G Bailey; J M Arnold; H A Strong; C Munoz; J David Spence
Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics.
Clinical pharmacology and therapeutics 1993;54(6):589-94.
1993: David G Bailey; J M Arnold; C Munoz; J David Spence
Grapefruit juice--felodipine interaction: mechanism, predictability, and effect of naringin.
Clinical pharmacology and therapeutics 1993;53(6):637-42.
1992: Ralph H Stern; D Freeman; J David Spence
Differences in metabolism of time-release and unmodified nicotinic acid: explanation of the differences in hypolipidemic action?
Metabolism: clinical and experimental 1992;41(8):879-81.
1991: Ralph H Stern; J David Spence; David J Freeman; A Parbtani
Tolerance to nicotinic acid flushing.
Clinical pharmacology and therapeutics 1991;50(1):66-70.
1991: J David Spence; M Bass; H C Robinson; H Cheung; L J Melendez; J M Arnold; S B Manuck
Prospective study of ambulatory monitoring and echocardiography in borderline hypertension.
Clinical and investigative medicine. Médecine clinique et experimentale 1991;14(3):241-50.
1991: David G Bailey; J David Spence; C Munoz; J M Arnold
Interaction of citrus juices with felodipine and nifedipine.
Lancet 1991;337(8736):268-9.
1989: David G Bailey; J David Spence; B Edgar; C D Bayliff; J M Arnold
Ethanol enhances the hemodynamic effects of felodipine.
Clinical and investigative medicine. Médecine clinique et experimentale 1989;12(6):357-62.
1989: J David Spence
Stepped care for hypertension is dead, but what will replace it?
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 1989;140(10):1133-6.
1989: J David Spence
Quantitative spectral analysis of carotid Doppler signal: evaluation as a method for measurement of drug effects.
Clinical and investigative medicine. Médecine clinique et experimentale 1989;12(2):82-9.
1986: J David Spence
Antihypertensive drugs and prevention of atherosclerotic stroke.
Stroke; a journal of cerebral circulation 1986;17(5):808-10.
1986: D G Wong; J David Spence; L Lamki; D Freeman; J W McDonald
Effect of non-steroidal anti-inflammatory drugs on control of hypertension by beta-blockers and diuretics.
Lancet 1986;1(8488):997-1001.
1985: J David Spence; R F Del Maestro
Hypertension in acute ischemic strokes. Treat.
Archives of neurology 1985;42(10):1000-2.
1985: J David Spence; D G Wong; R M Lindsay
Effects of triamterene and amiloride on urinary sediment in hypertensive patients taking hydrochlorothiazide.
Lancet 1985;2(8446):73-5.
1984: J David Spence; D G Wong; L J Melendez; P M Nichol; J D Brown
Increased prevalence of mitral valve prolapse in patients with migraine.
Canadian Medical Association journal 1984;131(12):1457-60.
1983: J David Spence
Effects of hydralazine versus propranolol on blood velocity patterns in patients with carotid stenosis.
Clinical science (London, England : 1979) 1983;65(1):91-3.
1982: J David Spence; A Donner
Problems in design of stroke treatment trials.
Stroke; a journal of cerebral circulation 1982;13(1):94-9.
1980: J David Spence; A L Amacher; N R Willis
Benign intracranial hypertension without papilledema: role of 24-hour cerebrospinal fluid pressure monitoring in diagnosis and management.
Neurosurgery 1980;7(4):326-36.
1979: J David Spence; W J Sibbald; R D Cape
Direct, indirect and mean blood pressures in hypertensive patients: the problem of cuff artefact due to arterial wall stiffness, and a partial solution.
Clinical and investigative medicine. Médecine clinique et experimentale 1979;2(4):165-73.
1978: J David Spence; W J Sibbald; R D Cape
Pseudohypertension in the elderly.
Clinical science and molecular medicine. Supplement 1978;4():399s-402s.
1977: J David Spence
Effects of antihypertensive drugs on blood velocity: implications for prevention of cerebral vascular disease.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1977;4(2):93-7.