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george Georgiou

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Escherichia coli

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TOP 3
Everett Stone; Lynne Chantranupong; george Georgiou
The second-shell metal ligands of human arginase affect coordination of the nucleophile and substrate.
Sai T Reddy; Xin Ge; Aleksandr E Miklos; Randall A Hughes; Seung Hyun Kang; Kam Hon Hoi; Constantine Chrysostomou; Scott P Hunicke-Smith; Brent L Iverson; Philip W Tucker; Andrew D Ellington; george Georgiou
Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells.
Georgios Skretas; george Georgiou
Simple genetic selection protocol for isolation of overexpressed genes that enhance accumulation of membrane-integrated human G protein-coupled receptors in Escherichia coli.

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All Publications

2010: Everett Stone; Lynne Chantranupong; george Georgiou
The second-shell metal ligands of human arginase affect coordination of the nucleophile and substrate.
Biochemistry 2010;49(49):10582-8.
2010: Sai T Reddy; Xin Ge; Aleksandr E Miklos; Randall A Hughes; Seung Hyun Kang; Kam Hon Hoi; Constantine Chrysostomou; Scott P Hunicke-Smith; Brent L Iverson; Philip W Tucker; Andrew D Ellington; george Georgiou
Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells.
Nature biotechnology 2010;28(9):965-9.
2010: Georgios Skretas; george Georgiou
Simple genetic selection protocol for isolation of overexpressed genes that enhance accumulation of membrane-integrated human G protein-coupled receptors in Escherichia coli.
Applied and environmental microbiology 2010;76(17):5852-9.
2010: Sang Taek Jung; Tae Hyun Kang; george Georgiou
Efficient expression and purification of human aglycosylated Fcgamma receptors in Escherichia coli.
Biotechnology and bioengineering 2010;107(1):21-30.
2010: T J Van Blarcom; C Sofer-Podesta; J Ang; J L Boyer; R G Crystal; george Georgiou
Affinity maturation of an anti-V antigen IgG expressed in situ through adenovirus gene delivery confers enhanced protection against Yersinia pestis challenge.
Gene therapy 2010;17(7):913-21.
2010: Xin Ge; Yariv Mazor; Scott P Hunicke-Smith; Andrew D Ellington; george Georgiou
Rapid construction and characterization of synthetic antibody libraries without DNA amplification.
Biotechnology and bioengineering 2010;106(3):347-57.
2010: Yariv Mazor; Thomas Van Blarcom; Sean Carroll; george Georgiou
Selection of full-length IgGs by tandem display on filamentous phage particles and Escherichia coli fluorescence-activated cell sorting screening.
The FEBS journal 2010;277(10):2291-303.
2010: Everett Stone; Evan S Glazer; Lynne Chantranupong; Paul Cherukuri; Robert M Breece; David L Tierney; Steven A Curley; Brent L Iverson; george Georgiou
Replacing Mn(2+) with Co(2+) in human arginase i enhances cytotoxicity toward l-arginine auxotrophic cancer cell lines.
ACS chemical biology 2010;5(3):333-42.
2010: Sang Taek Jung; Sai T Reddy; Tae Hyun Kang; M Jack Borrok; Inger Sandlie; Philip W Tucker; george Georgiou
Aglycosylated IgG variants expressed in bacteria that selectively bind FcgammaRI potentiate tumor cell killing by monocyte-dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(2):604-9.
2009: Navin Varadarajan; Mark Pogson; george Georgiou; Brent L Iverson
Proteases that can distinguish among different post-translational forms of tyrosine engineered using multicolor flow cytometry.
Journal of the American Chemical Society 2009;131(50):18186-90.
2009: Jason R Cantor; Everett Stone; Lynne Chantranupong; george Georgiou
The human asparaginase-like protein 1 hASRGL1 is an Ntn hydrolase with beta-aspartyl peptidase activity.
Biochemistry 2009;48(46):11026-31.
2009: Li Zhou; Meng Zhao; Rachel Z Wolf; David E Graham; george Georgiou
Transcriptional regulation of the Escherichia coli gene rraB, encoding a protein inhibitor of RNase E.
Journal of bacteriology 2009;191(21):6665-74.
2009: Mark Pogson; george Georgiou; Brent L Iverson
Engineering next generation proteases.
Current opinion in biotechnology 2009;20(4):390-7.
2009: Clinton E Leysath; Arthur F Monzingo; Jennifer A Maynard; Jason Barnett; george Georgiou; Brent L Iverson; Jon D Robertus
Crystal structure of the engineered neutralizing antibody M18 complexed to domain 4 of the anthrax protective antigen.
Journal of molecular biology 2009;387(3):680-93.
2009: Markus Eser; Lluis Masip; Hiroshi Kadokura; george Georgiou; Jonathan R. Beckwith
Disulfide bond formation by exported glutaredoxin indicates glutathione's presence in the E. coli periplasm.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(5):1572-7.
2009: Min Jeong Seo; Ki Jun Jeong; Clinton E Leysath; Andrew D Ellington; Brent L Iverson; george Georgiou
Engineering antibody fragments to fold in the absence of disulfide bonds.
Protein science : a publication of the Protein Society 2009;18(2):259-67.
2009: Georgios Skretas; george Georgiou
Genetic analysis of G protein-coupled receptor expression in Escherichia coli: inhibitory role of DnaJ on the membrane integration of the human central cannabinoid receptor.
Biotechnology and bioengineering 2009;102(2):357-67.
2009: Georgios Skretas; Sean Carroll; Shawn DeFrees; Marc F Schwartz; Karl F Johnson; george Georgiou
Expression of active human sialyltransferase ST6GalNAcI in Escherichia coli.
Microbial cell factories 2009;8():50.
2009: Navin Varadarajan; Jason R Cantor; george Georgiou; Brent L Iverson
Construction and flow cytometric screening of targeted enzyme libraries.
Nature protocols 2009;4(6):893-901.
2009: Yariv Mazor; Thomas Van Blarcom; Brent L Iverson; george Georgiou
Isolation of full-length IgG antibodies from combinatorial libraries expressed in Escherichia coli.
Methods in molecular biology (Clifton, N.J.) 2009;525():217-39, xiv.
2008: Silvia Arredondo; Laura Segatori; Hiram F Gilbert; george Georgiou
De novo design and evolution of artificial disulfide isomerase enzymes analogous to the bacterial DsbC.
The Journal of biological chemistry 2008;283(46):31469-76.
2008: A James Link; Georgios Skretas; Eva-Maria Strauch; Nandini S Chari; george Georgiou
Efficient production of membrane-integrated and detergent-soluble G protein-coupled receptors in Escherichia coli.
Protein science : a publication of the Protein Society 2008;17(10):1857-63.
2008: Georgios Skretas; george Georgiou
Engineering G protein-coupled receptor expression in bacteria.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(39):14747-8.
2008: Melinda J Faulkner; Karthik Veeravalli; stéphanie gon; george Georgiou; Jonathan R. Beckwith
Functional plasticity of a peroxidase allows evolution of diverse disulfide-reducing pathways.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(18):6735-40.
2008: Christian W Cobaugh; Juan Almagro; Mark Pogson; Brent L Iverson; george Georgiou
Synthetic antibody libraries focused towards peptide ligands.
Journal of molecular biology 2008;378(3):622-33.
2008: Navin Varadarajan; Sarah Rodriguez; Bum-Yeol Hwang; george Georgiou; Brent L Iverson
Highly active and selective endopeptidases with programmed substrate specificities.
Nature chemical biology 2008;4(5):290-4.
2008: Hai-Xin Li; Bum-Yeol Hwang; Gurunathan Laxmikanthan; Sachiko I Blaber; Michael Blaber; Pavel A Golubkov; Pengyu Ren; Brent L Iverson; george Georgiou
Substrate specificity of human kallikreins 1 and 6 determined by phage display.
Protein science : a publication of the Protein Society 2008;17(4):664-72.
2008: Lluis Masip; Daniel Klein-Marcuschamer; Shu Quan; James C A Bardwell; george Georgiou
Laboratory evolution of Escherichia coli thioredoxin for enhanced catalysis of protein oxidation in the periplasm reveals a phylogenetically conserved substrate specificity determinant.
The Journal of biological chemistry 2008;283(2):840-8.
2008: Yariv Mazor; Thomas Van Blarcom; Brent L Iverson; george Georgiou
E-clonal antibodies: selection of full-length IgG antibodies using bacterial periplasmic display.
Nature protocols 2008;3(11):1766-77.
2008: Navin Varadarajan; george Georgiou; Brent L Iverson
An engineered protease that cleaves specifically after sulfated tyrosine.
Angewandte Chemie (International ed. in English) 2008;47(41):7861-3.
2007: Eva-Maria Strauch; george Georgiou
Escherichia coli tatC mutations that suppress defective twin-arginine transporter signal peptides.
Journal of molecular biology 2007;374(2):283-91.
2007: A James Link; Ki Jun Jeong; george Georgiou
Beyond toothpicks: new methods for isolating mutant bacteria.
Nature reviews. Microbiology 2007;5(9):680-8.
2007: Sang Taek Jung; Ki Jun Jeong; Brent L Iverson; george Georgiou
Binding and enrichment of Escherichia coli spheroplasts expressing inner membrane tethered scFv antibodies on surface immobilized antigens.
Biotechnology and bioengineering 2007;98(1):39-47.
2007: Brian Ribnicky; Thomas Van Blarcom; george Georgiou
A scFv antibody mutant isolated in a genetic screen for improved export via the twin arginine transporter pathway exhibits faster folding.
Journal of molecular biology 2007;369(3):631-9.
2007: Ki Jun Jeong; Min Jeong Seo; Brent L Iverson; george Georgiou
APEx 2-hybrid, a quantitative protein-protein interaction assay for antibody discovery and engineering.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(20):8247-52.
2007: Eva-Maria Strauch; george Georgiou
A bacterial two-hybrid system based on the twin-arginine transporter pathway of E. coli.
Protein science : a publication of the Protein Society 2007;16(5):1001-8.
2007: Yariv Mazor; Thomas Van Blarcom; Robert Mabry; Brent L Iverson; george Georgiou
Isolation of engineered, full-length antibodies from libraries expressed in Escherichia coli.
Nature biotechnology 2007;25(5):563-5.
2007: Raphael Levy; Ian J Molineux; Brent L Iverson; george Georgiou
Isolation of trans-acting genes that enhance soluble expression of scFv antibodies in the E. coli cytoplasm by lambda phage display.
Journal of immunological methods 2007;321(1-2):164-73.
2007: Danielle Tullman-Ercek; Matthew P DeLisa; Yasuaki Kawarasaki; Pooya Iranpour; Brian Ribnicky; Tracy Palmer; george Georgiou
Export pathway selectivity of Escherichia coli twin arginine translocation signal peptides.
The Journal of biological chemistry 2007;282(11):8309-16.
2007: Bum-Yeol Hwang; Navin Varadarajan; Haixin Li; Sarah Rodriguez; Brent L Iverson; george Georgiou
Substrate specificity of the Escherichia coli outer membrane protease OmpP.
Journal of bacteriology 2007;189(2):522-30.
2006: Arti Pothukuchy; Nicolas Mano; george Georgiou; Adam Heller
A potentially insect-implantable trehalose electrooxidizing anode.
Biosensors & bioelectronics 2006;22(5):678-84.
2006: Karl E Griswold; Nandini S Aiyappan; Brent L Iverson; george Georgiou
The evolution of catalytic efficiency and substrate promiscuity in human theta class 1-1 glutathione transferase.
Journal of molecular biology 2006;364(3):400-10.
2006: Rozamond Y Sweeney; Eun Young Park; Brent L Iverson; george Georgiou
Assembly of multimeric phage nanostructures through leucine zipper interactions.
Biotechnology and bioengineering 2006;95(3):539-45.
2006: Junjun Gao; Kangseok Lee; Meng Zhao; Ji Qiu; Xiaoming Zhan; Ankur Saxena; Christopher J Moore; Stanley N Cohen; george Georgiou
Differential modulation of E. coli mRNA abundance by inhibitory proteins that alter the composition of the degradosome.
Molecular microbiology 2006;61(2):394-406.
2006: Robert Mabry; Kathleen M Brasky; Robert Geiger; Ricardo Carrion; Gene B Hubbard; Stephen H Leppla; Jean L Patterson; george Georgiou; Brent L Iverson
Detection of anthrax toxin in the serum of animals infected with Bacillus anthracis by using engineered immunoassays.
Clinical and vaccine immunology : CVI 2006;13(6):671-7.
2006: Lluis Masip; Karthik Veeravalli; george Georgiou
The many faces of glutathione in bacteria.
Antioxidants & redox signaling 2006;8(5-6):753-62.
2006: Meng Zhao; Li Zhou; Yasuaki Kawarasaki; george Georgiou
Regulation of RraA, a protein inhibitor of RNase E-mediated RNA decay.
Journal of bacteriology 2006;188(9):3257-63.
2006: Laura Segatori; Lori Murphy; Silvia Arredondo; Hiroshi Kadokura; Hiram Gilbert; Jonathan R. Beckwith; george Georgiou
Conserved role of the linker alpha-helix of the bacterial disulfide isomerase DsbC in the avoidance of misoxidation by DsbB.
The Journal of biological chemistry 2006;281(8):4911-9.
2006: Barrett R Harvey; Armen B Shanafelt; Irina Baburina; Raymond Hui; Steve Vitone; Brent L Iverson; george Georgiou
Engineering of recombinant antibody fragments to methamphetamine by anchored periplasmic expression.
Journal of immunological methods 2006;308(1-2):43-52.
2006: Philip A Lee; Danielle Tullman-Ercek; george Georgiou
The bacterial twin-arginine translocation pathway.
Annual review of microbiology 2006;60():373-95.
2005: Robert Mabry; Mridula Rani; Robert Geiger; Gene B Hubbard; Ricardo Carrion; Kathleen M Brasky; Jean L Patterson; george Georgiou; Brent L Iverson
Passive protection against anthrax by using a high-affinity antitoxin antibody fragment lacking an Fc region.
Infection and immunity 2005;73(12):8362-8.
2005: george Georgiou; Laura Segatori
Preparative expression of secreted proteins in bacteria: status report and future prospects.
Current opinion in biotechnology 2005;16(5):538-45.
2005: Jonathan G Pressman; george Georgiou; Gerald E Speitel
Scale-up considerations for a hollow-fiber-membrane bioreactor treating trichloroethylene-contaminated water.
Water environment research : a research publication of the Water Environment Federation 2005;77(5):533-42.
2005: Abhineet S Sheoran; Susan Chapman-Bonofiglio; Barrett R Harvey; Jean Mukherjee; george Georgiou; Arthur Donohue-Rolfe; Saul Tzipori
Human antibody against shiga toxin 2 administered to piglets after the onset of diarrhea due to Escherichia coli O157:H7 prevents fatal systemic complications.
Infection and immunity 2005;73(8):4607-13.
2005: Karl E Griswold; Yasuaki Kawarasaki; Nada Ghoneim; Stephen J Benkovic; Brent L Iverson; george Georgiou
Evolution of highly active enzymes by homology-independent recombination.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10082-7.
2005: george Georgiou; Ki Jun Jeong
Proteins from PHB granules.
Protein science : a publication of the Protein Society 2005;14(6):1385-6.
2005: Navin Varadarajan; Jongsik Gam; Mark J Olsen; george Georgiou; Brent L Iverson
Engineering of protease variants exhibiting high catalytic activity and exquisite substrate selectivity.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(19):6855-60.
2004: Rozamond Y Sweeney; Chuanbin Mao; Xiaoxia Gao; Justin L Burt; Angela M Belcher; george Georgiou; Brent L Iverson
Bacterial biosynthesis of cadmium sulfide nanocrystals.
Chemistry & biology 2004;11(11):1553-9.
2004: Man Zhang; Arthur F Monzingo; Laura Segatori; george Georgiou; Jon D Robertus
Structure of DsbC from Haemophilus influenzae.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 9):1512-8.
2004: Jun Jeong Ki; Yasuaki Kawarasaki; Jongsik Gam; Barrett R Harvey; Brent L Iverson; george Georgiou
A periplasmic fluorescent reporter protein and its application in high-throughput membrane protein topology analysis.
Journal of molecular biology 2004;341(4):901-9.
2004: Laura Segatori; Paul J Paukstelis; Hiram F Gilbert; george Georgiou
Engineered DsbC chimeras catalyze both protein oxidation and disulfide-bond isomerization in Escherichia coli: Reconciling two competing pathways.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(27):10018-23.
2004: Barrett R Harvey; george Georgiou; Andrew Hayhurst; Ki Jun Jeong; Brent L Iverson; Geoffrey K Rogers
Anchored periplasmic expression, a versatile technology for the isolation of high-affinity antibodies from Escherichia coli-expressed libraries.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(25):9193-8.
2004: Lluis Masip; Jonathan L Pan; Suranjana Haldar; James Penner-Hahn; Matthew P DeLisa; george Georgiou; James C A Bardwell; Jean Francois Collet
An engineered pathway for the formation of protein disulfide bonds.
Science (New York, N.Y.) 2004;303(5661):1185-9.
2004: Xiaoming Zhan; Junjun Gao; Chaitanya Jain; Michael J Cieslewicz; James R Swartz; george Georgiou
Genetic analysis of disulfide isomerization in Escherichia coli: expression of DsbC is modulated by RNase E-dependent mRNA processing.
Journal of bacteriology 2004;186(3):654-60.
2004: Chuanbin Mao; Daniel J Solis; Brian D Reiss; Stephen T Kottmann; Rozamond Y Sweeney; Andrew Hayhurst; george Georgiou; Brent L Iverson; Angela M Belcher
Virus-based toolkit for the directed synthesis of magnetic and semiconducting nanowires.
Science (New York, N.Y.) 2004;303(5655):213-7.
2004: Matthew P DeLisa; Philip Lee; Tracy Palmer; george Georgiou
Phage shock protein PspA of Escherichia coli relieves saturation of protein export via the Tat pathway.
Journal of bacteriology 2004;186(2):366-73.
2003: Yasuaki Kawarasaki; Karl E Griswold; James D Stevenson; Tzvia Selzer; Stephen J Benkovic; Brent L Iverson; george Georgiou
Enhanced crossover SCRATCHY: construction and high-throughput screening of a combinatorial library containing multiple non-homologous crossovers.
Nucleic acids research 2003;31(21):e126.
2003: Arthur F Monzingo; Junjun Gao; Ji Qiu; george Georgiou; Jon D Robertus
The X-ray structure of Escherichia coli RraA (MenG), A protein inhibitor of RNA processing.
Journal of molecular biology 2003;332(5):1015-24.
2003: Chuanbin Mao; Christine E Flynn; Andrew Hayhurst; Rozamond Y Sweeney; Jifa Qi; george Georgiou; Brent L Iverson; Angela M Belcher
Viral assembly of oriented quantum dot nanowires.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(12):6946-51.
2003: Ellen R Goldman; Andrew Hayhurst; Brian M Lingerfelt; Brent L Iverson; george Georgiou; George Anderson
2,4,6-Trinitrotoluene detection using recombinant antibodies.
Journal of environmental monitoring : JEM 2003;5(3):380-3.
2003: Matthew P DeLisa; Danielle Tullman; george Georgiou
Folding quality control in the export of proteins by the bacterial twin-arginine translocation pathway.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):6115-20.
2003: Andrew Hayhurst; Scott Happe; Robert Mabry; Zephyr Koch; Brent L Iverson; george Georgiou
Isolation and expression of recombinant antibody fragments to the biological warfare pathogen Brucella melitensis.
Journal of immunological methods 2003;276(1-2):185-96.
2003: george Georgiou; Lluis Masip
Biochemistry. An overoxidation journey with a return ticket.
Science (New York, N.Y.) 2003;300(5619):592-4.
2003: Mark J Olsen; Jongsik Gam; Brent L Iverson; george Georgiou
High-throughput FACS method for directed evolution of substrate specificity.
Methods in molecular biology (Clifton, N.J.) 2003;230():329-42.
2003: Ronald Lafond; Xiaoming Zhan; george Georgiou
Screening and selection strategies for disulfide isomerase activity.
Methods in molecular biology (Clifton, N.J.) 2003;230():239-57.
2003: Karl E Griswold; Nadir A Mahmood; Brent L Iverson; george Georgiou
Effects of codon usage versus putative 5'-mRNA structure on the expression of Fusarium solani cutinase in the Escherichia coli cytoplasm.
Protein expression and purification 2003;27(1):134-42.
2002: george Georgiou
How to flip the (redox) switch.
Cell 2002;111(5):607-10.
2002: J Colin Cox; Andrew Hayhurst; Jay R Hesselberth; Travis S Bayer; george Georgiou; Andrew D Ellington
Automated selection of aptamers against protein targets translated in vitro: from gene to aptamer.
Nucleic acids research 2002;30(20):e108.
2002: Matthew P DeLisa; Patrik Samuelson; Tracy Palmer; george Georgiou
Genetic analysis of the twin arginine translocator secretion pathway in bacteria.
The Journal of biological chemistry 2002;277(33):29825-31.
2002: Jennifer A Maynard; Catharina B M Maassen; Stephen H Leppla; Kathleen M Brasky; Jean L Patterson; Brent L Iverson; george Georgiou
Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity.
Nature biotechnology 2002;20(6):597-601.
2002: Jennifer A Maynard; Gang Chen; george Georgiou; Brent L Iverson
In vitro scanning-saturation mutagenesis.
Methods in molecular biology (Clifton, N.J.) 2002;182():149-63.
2001: Andrew Hayhurst; george Georgiou
High-throughput antibody isolation.
Current opinion in chemical biology 2001;5(6):683-9.
2001: R Levy; R Weiss; G Chen; Brent L Iverson; george Georgiou
Production of correctly folded Fab antibody fragment in the cytoplasm of Escherichia coli trxB gor mutants via the coexpression of molecular chaperones.
Protein expression and purification 2001;23(2):338-47.
2001: G Chen; Andrew Hayhurst; J G Thomas; Barrett R Harvey; Brent L Iverson; george Georgiou
Isolation of high-affinity ligand-binding proteins by periplasmic expression with cytometric screening (PECS).
Nature biotechnology 2001;19(6):537-42.
2001: C Y Liu; Gerald E Speitel; george Georgiou
Kinetics of methyl t-butyl ether cometabolism at low concentrations by pure cultures of butane-degrading bacteria.
Applied and environmental microbiology 2001;67(5):2197-201.
2001: Paul H Bessette; J Qiu; James C A Bardwell; James R Swartz; george Georgiou
Effect of sequences of the active-site dipeptides of DsbA and DsbC on in vivo folding of multidisulfide proteins in Escherichia coli.
Journal of bacteriology 2001;183(3):980-8.
2000: Mark J Olsen; D Stephens; D Griffiths; Patrick S Daugherty; george Georgiou; Brent L Iverson
Function-based isolation of novel enzymes from a large library.
Nature biotechnology 2000;18(10):1071-4.
2000: Patrick S Daugherty; Brent L Iverson; george Georgiou
Flow cytometric screening of cell-based libraries.
Journal of immunological methods 2000;243(1-2):211-27.
2000: M Olsen; Brent L Iverson; george Georgiou
High-throughput screening of enzyme libraries.
Current opinion in biotechnology 2000;11(4):331-7.
2000: Jonathan G Pressman; george Georgiou; Gerald E Speitel
A hollow-fiber membrane bioreactor for the removal of trichloroethylene from the vapor phase.
Biotechnology and bioengineering 2000;68(5):548-56.
2000: Patrick S Daugherty; G Chen; Brent L Iverson; george Georgiou
Quantitative analysis of the effect of the mutation frequency on the affinity maturation of single chain Fv antibodies.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2029-34.
2000: Jennifer A Maynard; george Georgiou
Antibody engineering.
Annual review of biomedical engineering 2000;2():339-76.
1999: Paul H Bessette; F Aslund; Jonathan R. Beckwith; george Georgiou
Efficient folding of proteins with multiple disulfide bonds in the Escherichia coli cytoplasm.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(24):13703-8.
1999: Xiaoming Zhan; M Schwaller; Hiram F Gilbert; george Georgiou
Facilitating the formation of disulfide bonds in the Escherichia coli periplasm via coexpression of yeast protein disulfide isomerase.
Biotechnology progress 1999;15(6):1033-8.
1999: C E Aziz; george Georgiou; Gerald E Speitel
Cometabolism of chlorinated solvents and binary chlorinated solvent mixtures using M. trichosporium OB3b PP358.
Biotechnology and bioengineering 1999;65(1):100-7.
1999: Patrick S Daugherty; Mark J Olsen; Brent L Iverson; george Georgiou
Development of an optimized expression system for the screening of antibody libraries displayed on the Escherichia coli surface.
Protein engineering 1999;12(7):613-21.
1999: B C Hoskins; L Fevang; P D Majors; MM Sharma; george Georgiou
Selective imaging of biofilms in porous media by NMR relaxation.
Journal of magnetic resonance (San Diego, Calif. : 1997) 1999;139(1):67-73.
1999: G Chen; I Dubrawsky; P Mendez; george Georgiou; Brent L Iverson
In vitro scanning saturation mutagenesis of all the specificity determining residues in an antibody binding site.
Protein engineering 1999;12(4):349-56.
1999: Jonathan G Pressman; george Georgiou; Gerald E Speitel
Demonstration of efficient trichloroethylene biodegradation in a hollow-fiber membrane bioreactor.
Biotechnology and bioengineering 1999;62(6):681-92.
1999: Paul H Bessette; J J Cotto; Hiram F Gilbert; george Georgiou
In vivo and in vitro function of the Escherichia coli periplasmic cysteine oxidoreductase DsbG.
The Journal of biological chemistry 1999;274(12):7784-92.
1999: george Georgiou; P Valax
Isolating inclusion bodies from bacteria.
Methods in enzymology 1999;309():48-58.
1998: J Qiu; James R Swartz; george Georgiou
Expression of active human tissue-type plasminogen activator in Escherichia coli.
Applied and environmental microbiology 1998;64(12):4891-6.
1998: A Razatos; Y L Ong; MM Sharma; george Georgiou
Molecular determinants of bacterial adhesion monitored by atomic force microscopy.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(19):11059-64.
1998: Patrick S Daugherty; G Chen; Mark J Olsen; Brent L Iverson; george Georgiou
Antibody affinity maturation using bacterial surface display.
Protein engineering 1998;11(9):825-32.
1998: A Razatos; Y L Ong; MM Sharma; george Georgiou
Evaluating the interaction of bacteria with biomaterials using atomic force microscopy.
Journal of biomaterials science. Polymer edition 1998;9(12):1361-73.
1997: Arne Rietsch; Paul H Bessette; george Georgiou; Jonathan R. Beckwith
Reduction of the periplasmic disulfide bond isomerase, DsbC, occurs by passage of electrons from cytoplasmic thioredoxin.
Journal of bacteriology 1997;179(21):6602-8.
1997: E A Burks; G Chen; george Georgiou; Brent L Iverson
In vitro scanning saturation mutagenesis of an antibody binding pocket.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):412-7.
1997: george Georgiou; C Stathopoulos; Patrick S Daugherty; A R Nayak; Brent L Iverson; Roy Curtis
Display of heterologous proteins on the surface of microorganisms: from the screening of combinatorial libraries to live recombinant vaccines.
Nature biotechnology 1997;15(1):29-34.
1996: G Chen; J Cloud; george Georgiou; Brent L Iverson
A quantitative immunoassay utilizing Escherichia coli cells possessing surface-expressed single chain Fv molecules.
Biotechnology progress 1996;12(4):572-4.
1996: M Ostermeier; K De Sutter; george Georgiou
Eukaryotic protein disulfide isomerase complements Escherichia coli dsbA mutants and increases the yield of a heterologous secreted protein with disulfide bonds.
The Journal of biological chemistry 1996;271(18):10616-22.
1996: george Georgiou; P Valax
Expression of correctly folded proteins in Escherichia coli.
Current opinion in biotechnology 1996;7(2):190-7.
1996: C Stathopoulos; george Georgiou; C F Earhart
Characterization of Escherichia coli expressing an Lpp'OmpA(46-159)-PhoA fusion protein localized in the outer membrane.
Applied microbiology and biotechnology 1996;45(1-2):112-9.
1996: george Georgiou; D L Stephens; C Stathopoulos; Heather Lee Klug-De Santiago; J Mendenhall; C F Earhart
Display of beta-lactamase on the Escherichia coli surface: outer membrane phenotypes conferred by Lpp'-OmpA'-beta-lactamase fusions.
Protein engineering 1996;9(2):239-47.
1995: george Georgiou
Recombinant DNA technology.
Trends in biotechnology 1995;13(3):79-80.
1994: J A Francisco; george Georgiou
The expression of recombinant proteins on the external surface of Escherichia coli. Biotechnological applications.
Annals of the New York Academy of Sciences 1994;745():372-82.
1994: H J Meerman; george Georgiou
Construction and characterization of a set of E. coli strains deficient in all known loci affecting the proteolytic stability of secreted recombinant proteins.
Bio/technology (Nature Publishing Company) 1994;12(11):1107-10.
1994: george Georgiou; P Valax; M Ostermeier; Paul M Horowitz
Folding and aggregation of TEM beta-lactamase: analogies with the formation of inclusion bodies in Escherichia coli.
Protein science : a publication of the Protein Society 1994;3(11):1953-60.
1994: M Ostermeier; george Georgiou
The folding of bovine pancreatic trypsin inhibitor in the Escherichia coli periplasm.
The Journal of biological chemistry 1994;269(33):21072-7.
1994: H J Meerman; george Georgiou
High-level production of proteolytically sensitive secreted proteins in Escherichia coli strains impaired in the heat-shock response.
Annals of the New York Academy of Sciences 1994;721():292-302.
1994: T M Przybycien; J P Dunn; P Valax; george Georgiou
Secondary structure characterization of beta-lactamase inclusion bodies.
Protein engineering 1994;7(1):131-6.
1994: S C Lin; M A Minton; MM Sharma; george Georgiou
Structural and immunological characterization of a biosurfactant produced by Bacillus licheniformis JF-2.
Applied and environmental microbiology 1994;60(1):31-8.
1993: J A Francisco; R Campbell; Brent L Iverson; george Georgiou
Production and fluorescence-activated cell sorting of Escherichia coli expressing a functional antibody fragment on the external surface.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(22):10444-8.
1993: M W Fitch; D W Graham; R G Arnold; S K Agarwal; P Phelps; Gerald E Speitel; george Georgiou
Phenotypic characterization of copper-resistant mutants of Methylosinus trichosporium OB3b.
Applied and environmental microbiology 1993;59(9):2771-6.
1993: P Valax; george Georgiou
Molecular characterization of beta-lactamase inclusion bodies produced in Escherichia coli. 1. Composition.
Biotechnology progress 1993;9(5):539-47.
1993: J A Francisco; C Stathopoulos; R A Warren; Douglas G Kilburn; george Georgiou
Specific adhesion and hydrolysis of cellulose by intact Escherichia coli expressing surface anchored cellulase or cellulose binding domains.
Bio/technology (Nature Publishing Company) 1993;11(4):491-5.
1993: george Georgiou; Heather Lee Klug-De Santiago; C Stathopoulos; J A Francisco
Practical applications of engineering gram-negative bacterial cell surfaces.
Trends in biotechnology 1993;11(1):6-10.
1992: P A Phelps; S K Agarwal; Gerald E Speitel; george Georgiou
Methylosinus trichosporium OB3b Mutants Having Constitutive Expression of Soluble Methane Monooxygenase in the Presence of High Levels of Copper.
Applied and environmental microbiology 1992;58(11):3701-8.
1992: François Baneyx; george Georgiou
Degradation of secreted proteins in Escherichia coli.
Annals of the New York Academy of Sciences 1992;665():301-8.
1992: G A Bowden; François Baneyx; george Georgiou
Abnormal fractionation of beta-lactamase in Escherichia coli: evidence for an interaction with the inner membrane in the absence of a leader peptide.
Journal of bacteriology 1992;174(10):3407-10.
1992: J A Francisco; C F Earhart; george Georgiou
Transport and anchoring of beta-lactamase to the external surface of Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):2713-7.
1992: george Georgiou; S C Lin; MM Sharma
Surface-active compounds from microorganisms.
Bio/technology (Nature Publishing Company) 1992;10(1):60-5.
1991: François Baneyx; A Ayling; T Palumbo; D Thomas; george Georgiou
Optimization of growth conditions for the production of proteolytically-sensitive proteins in the periplasmic space of Escherichia coli.
Applied microbiology and biotechnology 1991;36(1):14-20.
1991: G A Bowden; A M Paredes; george Georgiou
Structure and morphology of protein inclusion bodies in Escherichia coli.
Bio/technology (Nature Publishing Company) 1991;9(8):725-30.
1991: François Baneyx; george Georgiou
Construction and characterization of Escherichia coli strains deficient in multiple secreted proteases: protease III degrades high-molecular-weight substrates in vivo.
Journal of bacteriology 1991;173(8):2696-703.
1990: G A Bowden; george Georgiou
Folding and aggregation of beta-lactamase in the periplasmic space of Escherichia coli.
The Journal of biological chemistry 1990;265(28):16760-6.
1990: François Baneyx; C Schmidt; george Georgiou
Affinity immobilization of a genetically engineered bifunctional hybrid protein.
Enzyme and microbial technology 1990;12(5):337-42.
1990: François Baneyx; george Georgiou
In vivo degradation of secreted fusion proteins by the Escherichia coli outer membrane protease OmpT.
Journal of bacteriology 1990;172(1):491-4.
1990: george Georgiou; François Baneyx
Expression, purification, and immobilization of a protein A-beta-lactamase hybrid protein.
Annals of the New York Academy of Sciences 1990;589():139-47.