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José Castell

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Agustín Lahoz; Jessica Maines; Josep M Miquel; Manuel Rivas; Maya R Vilà; José V Castell; Myriam Fabre; M José Gómez-Lechón
An in vitro tool to assess cytochrome P450 drug biotransformation-dependent cytotoxicity in engineered HepG2 cells generated by using adenoviral vectors.
A Aranda; E Burello; José V Castell; G Quintas; L Sequedo; L Tolosa; L Gombau
Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay: a quantitative method for oxidative stress assessment of nanoparticle-treated cells.
Juan C García-Cañaveras; José V Castell; M Teresa Donato; Agustin Lahoz
Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method.

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2013: Agustín Lahoz; Jessica Maines; Josep M Miquel; Manuel Rivas; Maya R Vilà; José V Castell; Myriam Fabre; M José Gómez-Lechón
An in vitro tool to assess cytochrome P450 drug biotransformation-dependent cytotoxicity in engineered HepG2 cells generated by using adenoviral vectors.
Toxicology in vitro : an international journal published in association with BIBRA 2013;27(4):1410-5.
2013: A Aranda; E Burello; José V Castell; G Quintas; L Sequedo; L Tolosa; L Gombau
Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay: a quantitative method for oxidative stress assessment of nanoparticle-treated cells.
Toxicology in vitro : an international journal published in association with BIBRA 2013;27(2):954-63.
2012: Juan C García-Cañaveras; José V Castell; M Teresa Donato; Agustin Lahoz
Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method.
Journal of lipid research 2012;53(10):2231-41.
2012: Laia Tolosa; José V Castell; M Teresa Donato; Agustin Lahoz; J Enrique O'Connor; Sandra Pinto; M José Gómez-Lechón
Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs.
Toxicological sciences : an official journal of the Society of Toxicology 2012;127(1):187-98.
2012: M Teresa Donato; Nuria Jiménez; Laia Tolosa; José V Castell; M José Gómez-Lechón
High-content imaging technology for the evaluation of drug-induced steatosis using a multiparametric cell-based assay.
Journal of biomolecular screening 2012;17(3):394-400.
2012: María José Gómez-Lechón; Agustin Lahoz; José V Castell; M Teresa Donato
Evaluation of cytochrome P450 activities in human hepatocytes in vitro.
Methods in molecular biology (Clifton, N.J.) 2012;806():87-97.
2011: Juan C García-Cañaveras; José V Castell; M Teresa Donato; Agustin Lahoz
A comprehensive untargeted metabonomic analysis of human steatotic liver tissue by RP and HILIC chromatography coupled to mass spectrometry reveals important metabolic alterations.
Journal of proteome research 2011;10(10):4825-34.
2011: Laia Tolosa; Ana Bonora-Centelles; José V Castell; Silvia López; Alejandro Negro; Eugenia Pareja; M Teresa Donato; M José Gómez-Lechón
Steatotic liver: a suitable source for the isolation of hepatic progenitor cells.
Liver international : official journal of the International Association for the Study of the Liver 2011;31(8):1231-8.
2011: Laia Tolosa; Ana Bonora-Centelles; José V Castell; M Teresa Donato; Silvia López; Vicente Mirabet; Alejandro Negro; Eugenia Pareja; M José Gómez-Lechón
Influence of platelet lysate on the recovery and metabolic performance of cryopreserved human hepatocytes upon thawing.
Transplantation 2011;91(12):1340-6.
2010: M Cortés; Eugenia Pareja; José V Castell; Angel Moya; José Mir; Agustin Lahoz
Exploring mass spectrometry suitability to examine human liver graft metabonomic profiles.
Transplantation proceedings 2010;42(8):2953-8.
2010: M José Gómez-Lechón; Laia Tolosa; José V Castell; M Teresa Donato
Mechanism-based selection of compounds for the development of innovative in vitro approaches to hepatotoxicity studies in the LIINTOP project.
Toxicology in vitro : an international journal published in association with BIBRA 2010;24(7):1879-89.
2010: Marta Benet; Agustin Lahoz; Carla Guzmán; José V Castell; Ramiro Jover
CCAAT/enhancer-binding protein alpha (C/EBPalpha) and hepatocyte nuclear factor 4alpha (HNF4alpha) synergistically cooperate with constitutive androstane receptor to transactivate the human cytochrome P450 2B6 (CYP2B6) gene: application to the development of a metabolically competent human hepatic cell model.
The Journal of biological chemistry 2010;285(37):28457-71.
2010: M Teresa Donato; David Hallifax; Laura Picazo; José V Castell; J Brian Houston; M José Gomez-Lechón; Agustin Lahoz
Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam, and midazolam in adenoviral cytochrome P450-transfected HepG2 cells and comparison with hepatocytes and in vivo.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(9):1449-55.
2010: M José Gómez-Lechón; Agustin Lahoz; L Gombau; José V Castell; M Teresa Donato
In vitro evaluation of potential hepatotoxicity induced by drugs.
Current pharmaceutical design 2010;16(17):1963-77.
2010: Marta Moya; M José Gómez-Lechón; José V Castell; Ramiro Jover
Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile.
Chemico-biological interactions 2010;184(3):376-87.
2010: M Teresa Donato; Sandra Montero; José V Castell; M José Gómez-Lechón; Agustin Lahoz
Validated assay for studying activity profiles of human liver UGTs after drug exposure: inhibition and induction studies.
Analytical and bioanalytical chemistry 2010;396(6):2251-63.
2010: María José Gómez-Lechón; José V Castell; M Teresa Donato
The use of hepatocytes to investigate drug toxicity.
Methods in molecular biology (Clifton, N.J.) 2010;640():389-415.
2010: A Bonora-Centelles; M Teresa Donato; Agustin Lahoz; Eugenia Pareja; José Mir; José V Castell; M José Gómez-Lechón
Functional characterization of hepatocytes for cell transplantation: customized cell preparation for each receptor.
Cell transplantation 2010;19(1):21-8.
2009: M Teresa Donato; Alicia Martínez-Romero; Nuria Jiménez; Alejandro Negro; Guadalupe Herrera; José V Castell; Jose-Enrique O'Connor; M José Gómez-Lechón
Cytometric analysis for drug-induced steatosis in HepG2 cells.
Chemico-biological interactions 2009;181(3):417-23.
2009: F Javier Silvestre; Angel Puente; José V Bagán; José V Castell
Presence of fibronectin peptides in saliva of patients with Sjögren's syndrome: a potential indicator of salivary gland destruction.
Medicina oral, patología oral y cirugía bucal 2009;14(8):e365-70.
2009: Idania Rodeiro; María T Donato; Nuria Jimenez; Gabino Garrido; Jorge Molina-Torres; Roberto Menendez; José V Castell; M José Gómez-Lechón
Inhibition of human P450 enzymes by natural extracts used in traditional medicine.
Phytotherapy research : PTR 2009;23(2):279-82.
2009: A Bonora-Centelles; R Jover; Vicente Mirabet; Agustin Lahoz; F Carbonell; José V Castell; M José Gómez-Lechón
Sequential hepatogenic transdifferentiation of adipose tissue-derived stem cells: relevance of different extracellular signaling molecules, transcription factors involved, and expression of new key marker genes.
Cell transplantation 2009;18(12):1319-40.
2008: Agustin Lahoz; M Teresa Donato; Laura Picazo; José V Castell; M José Gómez-Lechón
Assessment of cytochrome P450 induction in human hepatocytes using the cocktail strategy plus liquid chromatography tandem mass spectrometry.
Drug metabolism letters 2008;2(3):205-9.
2008: Idania Rodeiro; M Teresa Donato; I Martínez; I Hernández; Gabino Garrido; J A González-Lavaut; R Menéndez; A Laguna; José V Castell; M José Gómez-Lechón
Potential hepatoprotective effects of new Cuban natural products in rat hepatocytes culture.
Toxicology in vitro : an international journal published in association with BIBRA 2008;22(5):1242-9.
2008: M José Gómez-Lechón; José V Castell; M Teresa Donato
An update on metabolism studies using human hepatocytes in primary culture.
Expert opinion on drug metabolism & toxicology 2008;4(7):837-54.
2008: Maya Pascual; M José Gómez-Lechón; José V Castell; Ramiro Jover
ATF5 is a highly abundant liver-enriched transcription factor that cooperates with constitutive androstane receptor in the transactivation of CYP2B6: implications in hepatic stress responses.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(6):1063-72.
2008: Idania Rodeiro; M Teresa Donato; Agustin Lahoz; J A González-Lavaut; A Laguna; José V Castell; R Delgado; M José Gómez-Lechón
Modulation of P450 enzymes by Cuban natural products rich in polyphenolic compounds in rat hepatocytes.
Chemico-biological interactions 2008;172(1):1-10.
2008: M Teresa Donato; Agustin Lahoz; Sandra Montero; Ana Bonora; Eugenia Pareja; José Mir; José V Castell; M José Gómez-Lechón
Functional assessment of the quality of human hepatocyte preparations for cell transplantation.
Cell transplantation 2008;17(10-11):1211-9.
2008: María José Gómez-Lechón; Jose-Enrique O'Connor; Agustin Lahoz; José V Castell; María Teresa Donato
Identification of apoptotic drugs: multiparametric evaluation in cultured hepatocytes.
Current medicinal chemistry 2008;15(20):2071-85.
2008: Agustin Lahoz; M Teresa Donato; José V Castell; M José Gómez-Lechón
Strategies to in vitro assessment of major human CYP enzyme activities by using liquid chromatography tandem mass spectrometry.
Current drug metabolism 2008;9(1):12-9.
2008: M Teresa Donato; Agustin Lahoz; José V Castell; M José Gómez-Lechón
Cell lines: a tool for in vitro drug metabolism studies.
Current drug metabolism 2008;9(1):1-11.
2008: Agustin Lahoz; M Teresa Donato; Sandra Montero; José V Castell; M José Gómez-Lechón
A new in vitro approach for the simultaneous determination of phase I and phase II enzymatic activities of human hepatocyte preparations.
Rapid communications in mass spectrometry : RCM 2008;22(2):240-4.
2007: Agustin Lahoz; M Teresa Donato; L Picazo; M José Gómez-Lechón; José V Castell
Determination of major human cytochrome P450s activities in 96-well plates using liquid chromatography tandem mass spectrometry.
Toxicology in vitro : an international journal published in association with BIBRA 2007;21(7):1247-52.
2007: Virginie Lhiaubet-Vallet; M Consuelo Cuquerella; José V Castell; Francisco Bosca; Miguel A Miranda
Triplet excited fluoroquinolones as mediators for thymine cyclobutane dimer formation in DNA.
The journal of physical chemistry. B 2007;111(25):7409-14.
2007: M José Gómez-Lechón; José V Castell; M Teresa Donato
Hepatocytes--the choice to investigate drug metabolism and toxicity in man: in vitro variability as a reflection of in vivo.
Chemico-biological interactions 2007;168(1):30-50.
2007: Raquel Taléns-Visconti; A Bonora; Ramiro Jover; Vicente Mirabet; Francisco Carbonell; José V Castell; M José Gómez-Lechón
Human mesenchymal stem cells from adipose tissue: Differentiation into hepatic lineage.
Toxicology in vitro : an international journal published in association with BIBRA 2007;21(2):324-9.
2007: M Teresa Donato; Nuria Jiménez; Alfonso Serralta; José Mir; José V Castell; M José Gómez-Lechón
Effects of steatosis on drug-metabolizing capability of primary human hepatocytes.
Toxicology in vitro : an international journal published in association with BIBRA 2007;21(2):271-6.
2007: Celia P Martínez-Jiménez; Ramiro Jover; M Teresa Donato; José V Castell; M José Gómez-Lechón
Transcriptional regulation and expression of CYP3A4 in hepatocytes.
Current drug metabolism 2007;8(2):185-94.
2007: M José Gómez-Lechón; M Teresa Donato; Alicia Martínez-Romero; Nuria Jiménez; José V Castell; Jose-Enrique O'Connor
A human hepatocellular in vitro model to investigate steatosis.
Chemico-biological interactions 2007;165(2):106-16.
2006: Celia P Martínez-Jiménez; José V Castell; M José Gómez-Lechón; Ramiro Jover
Transcriptional activation of CYP2C9, CYP1A1, and CYP1A2 by hepatocyte nuclear factor 4alpha requires coactivators peroxisomal proliferator activated receptor-gamma coactivator 1alpha and steroid receptor coactivator 1.
Molecular pharmacology 2006;70(5):1681-92.
2006: Celia P Martínez-Jiménez; M José Gómez-Lechón; José V Castell; Ramiro Jover
Underexpressed coactivators PGC1alpha and SRC1 impair hepatocyte nuclear factor 4 alpha function and promote dedifferentiation in human hepatoma cells.
The Journal of biological chemistry 2006;281(40):29840-9.
2006: Raquel Taléns-Visconti; Ana Bonora; Ramiro Jover; Vicente Mirabet; Francisco Carbonell; José V Castell; M José Gómez-Lechón
Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells.
World journal of gastroenterology : WJG 2006;12(36):5834-45.
2006: Agustin Lahoz; L Gombau; M Teresa Donato; José V Castell; M José Gómez-Lechón
In vitro ADME medium/high-throughput screening in drug preclinical development.
Mini reviews in medicinal chemistry 2006;6(9):1053-62.
2006: M Teresa Donato; Agustin Lahoz; Nuria Jiménez; Gabriela Pérez; Alfonso Serralta; José Mir; José V Castell; M José Gómez-Lechón
Potential impact of steatosis on cytochrome P450 enzymes of human hepatocytes isolated from fatty liver grafts.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(9):1556-62.
2006: Raquel Taléns-Visconti; Ana Bonora-Centelles; José V Castell; M José Gómez-Lechón
[Alternative sources of hepatocytes for cell therapy].
Gastroenterología y hepatología 2006;29(6):366-76.
2006: L Gombau; F García; Agustin Lahoz; Myriam Fabre; Pedro Roda-Navarro; Pedro Majano; José Luis Alonso-Lebrero; Juan Pablo Pivel; José V Castell; M J Gómez-Lechon; Salvador González
Polypodium leucotomos extract: antioxidant activity and disposition.
Toxicology in vitro : an international journal published in association with BIBRA 2006;20(4):464-71.
2006: Francisco Bosca; Virginie Lhiaubet-Vallet; M Consuelo Cuquerella; José V Castell; Miguel A Miranda
The triplet energy of thymine in DNA.
Journal of the American Chemical Society 2006;128(19):6318-9.
2006: José V Castell; Ramiro Jover; Celia P Martínez-Jiménez; M José Gómez-Lechón
Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies.
Expert opinion on drug metabolism & toxicology 2006;2(2):183-212.
2006: Francisco Bosca; Patrice Morlière; Miguel A Miranda; José V Castell; René Santus
Primary steps of the photochemical reactions of 2-cyano-10-(3-[dimethylamino, N-oxide]-2-methylpropyl)-5-oxide-phenothiazine, the photoproduct of cyamemazine, a phototoxic neuroleptic: comparison with the sulfoxide.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2006;5(3):336-42.
2005: Celia P Martínez-Jiménez; M José Gómez-Lechón; José V Castell; Ramiro Jover
Transcriptional regulation of the human hepatic CYP3A4: identification of a new distal enhancer region responsive to CCAAT/enhancer-binding protein beta isoforms (liver activating protein and liver inhibitory protein).
Molecular pharmacology 2005;67(6):2088-101.
2005: Alfonso Serralta; M Teresa Donato; Amparo Martinez; Eugenia Pareja; Francisco Orbis; José V Castell; José Mir; M José Gómez-Lechón
Influence of preservation solution on the isolation and culture of human hepatocytes from liver grafts.
Cell transplantation 2005;14(10):837-43.
2005: Jose-Enrique O'Connor; Alicia Martínez; José V Castell; M José Gómez-Lechón
Multiparametric characterization by flow cytometry of flow-sorted subpopulations of a human hepatoma cell line useful for drug research.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2005;63(1):48-58.
2005: M Teresa Donato; Alfonso Serralta; Nuria Jiménez; Gabriela Pérez; José V Castell; José Mir; M José Gómez-Lechón
Liver grafts preserved in Celsior solution as source of hepatocytes for drug metabolism studies: comparison with surgical liver biopsies.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(1):108-14.
2004: M José Gómez-Lechón; Alfonso Serralta; M Teresa Donato; Nuria Jiménez; Enrique O'Connor; José V Castell; José Mir
The immunosuppressant drug FK506 prevents Fas-induced apoptosis in human hepatocytes.
Biochemical pharmacology 2004;68(12):2427-33.
2004: Patrice Morlière; Francisco Bosca; Miguel A Miranda; José V Castell; René Santus
Primary photochemical processes of the phototoxic neuroleptic cyamemazine: a study by laser flash photolysis and steady-state irradiation.
Photochemistry and photobiology 2004;80(3):535-41.
2004: M José Gómez-Lechón; M Teresa Donato; José V Castell; Ramiro Jover
Human hepatocytes in primary culture: the choice to investigate drug metabolism in man.
Current drug metabolism 2004;5(5):443-62.
2004: M Teresa Donato; Nuria Jiménez; José V Castell; M José Gómez-Lechón
Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymes.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(7):699-706.
2004: Xavier Ponsoda; M Teresa Donato; Gabriela Perez-Cataldo; M José Gómez-Lechón; José V Castell
Drug metabolism by cultured human hepatocytes: how far are we from the in vivo reality?
Alternatives to laboratory animals : ATLA 2004;32(2):101-10.
2004: Roque Bort; M José Gómez-Lechón; José V Castell; Ramiro Jover
Role of hepatocyte nuclear factor 3 gamma in the expression of human CYP2C genes.
Archives of biochemistry and biophysics 2004;426(1):63-72.
2003: M José Gómez-Lechón; Xavier Ponsoda; Enrique O'Connor; Teresa Donato; José V Castell; Ramiro Jover
Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS.
Biochemical pharmacology 2003;66(11):2155-67.
2003: Alfonso Serralta; M Teresa Donato; Francisco Orbis; José V Castell; José Mir; M José Gómez-Lechón
Functionality of cultured human hepatocytes from elective samples, cadaveric grafts and hepatectomies.
Toxicology in vitro : an international journal published in association with BIBRA 2003;17(5-6):769-74.
2003: M José Gómez-Lechón; Xavier Ponsoda; Enrique O'Connor; Teresa Donato; Ramiro Jover; José V Castell
Diclofenac induces apoptosis in hepatocytes.
Toxicology in vitro : an international journal published in association with BIBRA 2003;17(5-6):675-80.
2003: Virginie Lhiaubet-Vallet; Zaideth Sarabia; D Hernández; José V Castell; Miguel A Miranda
In vitro studies on DNA-photosensitization by different drug stereoisomers.
Toxicology in vitro : an international journal published in association with BIBRA 2003;17(5-6):651-6.
2003: Gabriela Pérez; Beatriz Tabares; Ramiro Jover; M José Gómez-Lechón; José V Castell
Semi-automatic quantitative RT-PCR to measure CYP induction by drugs in human hepatocytes.
Toxicology in vitro : an international journal published in association with BIBRA 2003;17(5-6):643-9.
2003: M José Gómez-Lechón; M Teresa Donato; José V Castell; Ramiro Jover
Human hepatocytes as a tool for studying toxicity and drug metabolism.
Current drug metabolism 2003;4(4):292-312.
2003: Lavinia Cantoni; Rea Valaperta; Xavier Ponsoda; José V Castell; Davide Barelli; Milena Rizzardini; Alessandra Mangolini; Lisa Hauri; Pia Villa
Induction of hepatic heme oxygenase-1 by diclofenac in rodents: role of oxidative stress and cytochrome P-450 activity.
Journal of hepatology 2003;38(6):776-83.
2003: M José Gómez-Lechón; Teresa Donato; Xavier Ponsoda; José V Castell
Human hepatic cell cultures: in vitro and in vivo drug metabolism.
Alternatives to laboratory animals : ATLA 2003;31(3):257-65.
2003: M Teresa Donato; Rainer Klocke; José V Castell; K Stenzel; D Paul; M José Gómez-Lechón
Constitutive and inducible expression of CYP enzymes in immortal hepatocytes derived from SV40 transgenic mice.
Xenobiotica; the fate of foreign compounds in biological systems 2003;33(5):459-73.
2003: C Rodríguez-Antona; Roque Bort; Ramiro Jover; N Tindberg; M Ingelman-Sundberg; M José Gómez-Lechón; José V Castell
Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma.
Molecular pharmacology 2003;63(5):1180-9.
2003: M Teresa Donato; José V Castell
Strategies and molecular probes to investigate the role of cytochrome P450 in drug metabolism: focus on in vitro studies.
Clinical pharmacokinetics 2003;42(2):153-78.
2002: Ramiro Jover; Roque Bort; M José Gómez-Lechón; José V Castell
Down-regulation of human CYP3A4 by the inflammatory signal interleukin-6: molecular mechanism and transcription factors involved.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(13):1799-801.
2002: Rainer Klocke; M José Gómez-Lechón; Anja Ehrhardt; Tomas Mendoza-Figueroa; M Teresa Donato; Rubén López-Revilla; José V Castell; Dieter Paul
Establishment and characterization of immortal hepatocytes derived from various transgenic mouse lines.
Biochemical and biophysical research communications 2002;294(4):864-71.
2002: C Rodríguez-Antona; M Teresa Donato; A Boobis; R J Edwards; P S Watts; José V Castell; M José Gómez-Lechón
Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells.
Xenobiotica; the fate of foreign compounds in biological systems 2002;32(6):505-20.
2002: M José Gómez-Lechón; Enrique O'Connor; José V Castell; Ramiro Jover
Sensitive markers used to identify compounds that trigger apoptosis in cultured hepatocytes.
Toxicological sciences : an official journal of the Society of Toxicology 2002;65(2):299-308.
2001: Agustin Lahoz; D Hernández; Miguel A Miranda; Julia Pérez-Prieto; Isabel M Morera; José V Castell
Antibodies directed to drug epitopes to investigate the structure of drug-protein photoadducts. Recognition of a common photobound substructure in tiaprofenic acid/ketoprofen cross-photoreactivity.
Chemical research in toxicology 2001;14(11):1486-91.
2001: C Rodríguez-Antona; M Teresa Donato; Eugenia Pareja; M José Gómez-Lechón; José V Castell
Cytochrome P-450 mRNA expression in human liver and its relationship with enzyme activity.
Archives of biochemistry and biophysics 2001;393(2):308-15.
2001: M Teresa Donato; Xavier Ponsoda; Enrique O'Connor; José V Castell; M José Gómez-Lechón
Role of endogenous nitric oxide in liver-specific functions and survival of cultured rat hepatocytes.
Xenobiotica; the fate of foreign compounds in biological systems 2001;31(5):249-64.
2001: M José Gómez-Lechón; Xavier Ponsoda; Roque Bort; José V Castell
The use of cultured hepatocytes to investigate the metabolism of drugs and mechanisms of drug hepatotoxicity.
Alternatives to laboratory animals : ATLA 2001;29(3):225-31.
2001: M José Gómez-Lechón; Teresa Donato; Ramiro Jover; C Rodriguez; Xavier Ponsoda; Denise Glaise; José V Castell; Christiane Guguen-Guillouzo
Expression and induction of a large set of drug-metabolizing enzymes by the highly differentiated human hepatoma cell line BC2.
European journal of biochemistry / FEBS 2001;268(5):1448-59.
2001: Ramiro Jover; Roque Bort; M José Gómez-Lechón; José V Castell
Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: a study using adenovirus-mediated antisense targeting.
Hepatology (Baltimore, Md.) 2001;33(3):668-75.
2001: Julio Cortijo; E Urbieta; Roque Bort; José V Castell; C Ruiz-Bravo; J Martinez; R Palacios-Pelaez; Salvador Lledó; Esteban J Morcillo
Biotransformation in vitro of the 22R and 22S epimers of budesonide by human liver, bronchus, colonic mucosa and skin.
Fundamental & clinical pharmacology 2001;15(1):47-54.
2001: Xavier Ponsoda; Eugenia Pareja; M José Gómez-Lechón; Ricardo Fabra; E Carrasco; Ramón Trullenque; José V Castell
Drug biotransformation by human hepatocytes. In vitro/in vivo metabolism by cells from the same donor.
Journal of hepatology 2001;34(1):19-25.
2000: M Teresa Donato; Pirkko Viitala; C Rodriguez-Antona; Aija Lindfors; José V Castell; Hannu Raunio; M José Gómez-Lechón; Olavi Pelkonen
CYP2A5/CYP2A6 expression in mouse and human hepatocytes treated with various in vivo inducers.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(11):1321-6.
2000: Zaideth Sarabia; D Hernández; José V Castell; Gerard M J Beijersbergen van Henegouwen
Photoreactivity of tiaprofenic acid and suprofen using pig skin as an ex vivo model.
Journal of photochemistry and photobiology. B, Biology 2000;58(1):32-6.
2000: C Rodríguez-Antona; Ramiro Jover; M José Gómez-Lechón; José V Castell
Quantitative RT-PCR measurement of human cytochrome P-450s: application to drug induction studies.
Archives of biochemistry and biophysics 2000;376(1):109-16.
2000: M José Gómez-Lechón; José V Castell; Teresa Donato; Sascha Pahernik; Wolfgang E Thasler; HG Koebe; Michael Doser; Martin Dauner; Heinrich Planck
New non-woven polyurethane-based biomaterials for the cultivation of hepatocytes: expression of differentiated functions.
Journal of materials science. Materials in medicine 2000;11(1):37-41.
2000: M José Gómez-Lechón; Ramiro Jover; Teresa Donato; Xavier Ponsoda; José V Castell
Expression of liver specific-genes in hepatocytes cultured in collagen gel matrix.
Progress in molecular and subcellular biology 2000;25():89-104.
1999: Xavier Ponsoda; Roque Bort; Ramiro Jover; M José Gómez-Lechón; José V Castell
Increased toxicity of cocaine on human hepatocytes induced by ethanol: role of GSH.
Biochemical pharmacology 1999;58(10):1579-85.
1999: M Teresa Donato; José V Castell; M José Gómez-Lechón
Characterization of drug metabolizing activities in pig hepatocytes for use in bioartificial liver devices: comparison with other hepatic cellular models.
Journal of hepatology 1999;31(3):542-9.
1999: Miguel A Miranda; Zaideth Sarabia; D Hernández; Isabel M Morera; M José Gómez-Lechón; José V Castell
An In Vitro Approach to Drug Photoallergy: Use of Drug-directed Antibodies to Assess Photobinding of Non-steroidal Anti-inflammatories to Skin Cells.
Toxicology in vitro : an international journal published in association with BIBRA 1999;13(4-5):701-5.
1999: Roque Bort; José V Castell; A Pfeifer; M José Gómez-Lechón; Katherine Macé
High Expression of Human CYP2C in Immortalized Human Liver Epithelial Cells.
Toxicology in vitro : an international journal published in association with BIBRA 1999;13(4-5):633-8.
1999: Roque Bort; Xavier Ponsoda; Ramiro Jover; M José Gómez-Lechón; José V Castell
Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity.
The Journal of pharmacology and experimental therapeutics 1999;288(1):65-72.
1998: M José Gómez-Lechón; Ramiro Jover; Teresa Donato; Xavier Ponsoda; C Rodriguez; K G Stenzel; Rainer Klocke; D Paul; Isabel Guillén; Roque Bort; José V Castell
Long-term expression of differentiated functions in hepatocytes cultured in three-dimensional collagen matrix.
Journal of cellular physiology 1998;177(4):553-62.
1998: José V Castell; D Hernández; M José Gómez-Lechón; Agustin Lahoz; Miguel A Miranda; Isabel M Morera; Julia Pérez-Prieto; Zaideth Sarabia
Photobinding of tiaprofenic acid and suprofen to proteins and cells: a combined study using radiolabeling, antibodies and laser flash photolysis of model bichromophores.
Photochemistry and photobiology 1998;68(5):660-5.
1998: José V Castell
Allergic hepatitis: a drug-mediated organ-specific immune reaction.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1998;28 Suppl 4():13-9.
1998: María Carmen Terencio; Isabel Guillén; M José Gómez-Lechón; M A Miranda; José V Castell
Release of inflammatory mediators (PGE2, IL-6) by fenofibric acid-photosensitized human keratinocytes and fibroblasts.
Photochemistry and photobiology 1998;68(3):331-6.
1998: Ramiro Jover; Roque Bort; M José Gómez-Lechón; José V Castell
Re-expression of C/EBP alpha induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells.
FEBS letters 1998;431(2):227-30.
1998: M I Guillén; M Teresa Donato; Ramiro Jover; José V Castell; Ricardo Fabra; Ramón Trullenque; M José Gómez-Lechón
Oncostatin M down-regulates basal and induced cytochromes P450 in human hepatocytes.
The Journal of pharmacology and experimental therapeutics 1998;285(1):127-34.
1998: Miguel A Miranda; José V Castell; D Hernández; M José Gómez-Lechón; Francisco Bosca; Isabel M Morera; Zaideth Sarabia
Drug-photosensitized protein modification: identification of the reactive sites and elucidation of the reaction mechanisms with tiaprofenic acid/albumin as model system.
Chemical research in toxicology 1998;11(3):172-7.
1998: M Teresa Donato; M José Gómez-Lechón; Ramiro Jover; T Nakamura; José V Castell
Human hepatocyte growth factor down-regulates the expression of cytochrome P450 isozymes in human hepatocytes in primary culture.
The Journal of pharmacology and experimental therapeutics 1998;284(2):760-7.
1997: Miguel A Miranda; José V Castell; Zaideth Sarabia; D Hernández; I Puertes; Isabel M Morera; M José Gómez-Lechón
Mechanisms of photosensitization by drugs: Involvement of tyrosines in the photomodification of proteins mediated by tiaprofenic acid in vitro.
Toxicology in vitro : an international journal published in association with BIBRA 1997;11(5):653-9.
1997: H de Vries; S Encinas; M A Miranda; José V Castell; G M Beijersbergen an Henegouwen
Photodegradation and photobinding of tiaprofenic acid: in vitro versus in vivo.
Photochemistry and photobiology 1997;66(4):432-5.
1997: José V Castell; M José Gómez-Lechón; Xavier Ponsoda; Roque Bort
The use of cultured hepatocytes to investigate the mechanisms of drug hepatotoxicity.
Cell biology and toxicology 1997;13(4-5):331-8.
1997: José V Castell; G Friedrich; C S Kuhn; G E Poppe
Intestinal absorption of undegraded proteins in men: presence of bromelain in plasma after oral intake.
The American journal of physiology 1997;273(1 Pt 1):G139-46.
1997: José V Castell; D Hernández; A M Gómez-Foix; Isabel Guillén; Teresa Donato; M José Gómez-Lechón
Adenovirus-mediated gene transfer into human hepatocytes: analysis of the biochemical functionality of transduced cells.
Gene therapy 1997;4(5):455-64.
1997: M Teresa Donato; M I Guillén; Ramiro Jover; José V Castell; M José Gómez-Lechón
Nitric oxide-mediated inhibition of cytochrome P450 by interferon-gamma in human hepatocytes.
The Journal of pharmacology and experimental therapeutics 1997;281(1):484-90.
1997: José V Castell; M José Gómez-Lechón; Xavier Ponsoda; Roque Bort
In vitro investigation of the molecular mechanisms of hepatotoxicity.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1997;19():313-21.
1996: Roque Bort; Xavier Ponsoda; E Carrasco; M José Gómez-Lechón; José V Castell
Comparative metabolism of the nonsteroidal antiinflammatory drug, aceclofenac, in the rat, monkey, and human.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(9):969-75.
1996: Roque Bort; Xavier Ponsoda; E Carrasco; M José Gómez-Lechón; José V Castell
Metabolism of aceclofenac in humans.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(8):834-41.
1996: M I Guillén; M José Gómez-Lechón; T Nakamura; José V Castell
The hepatocyte growth factor regulates the synthesis of acute-phase proteins in human hepatocytes: divergent effect on interleukin-6-stimulated genes.
Hepatology (Baltimore, Md.) 1996;23(6):1345-52.
1996: M José Gómez-Lechón; J Carrasquer; J Berenguer; José V Castell
Evidence of antibodies to erythromycin in serum of a patient following an episode of acute drug-induced hepatitis.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1996;26(5):590-6.
1996: M José Gómez-Lechón; Xavier Ponsoda; José V Castell
A microassay for measuring glycogen in 96-well-cultured cells.
Analytical biochemistry 1996;236(2):296-301.
1996: M José Gómez-Lechón; Isabel Guillén; Xavier Ponsoda; R Fabra; R Trullenque; T Nakamura; José V Castell
Cell cycle progression proteins (cyclins), oncogene expression, and signal transduction during the proliferative response of human hepatocytes to hepatocyte growth factor.
Hepatology (Baltimore, Md.) 1996;23(5):1012-9.
1995: M L Gil; M C Ramirez; María Carmen Terencio; José V Castell
Immunochemical detection of protein adducts in cultured human hepatocytes exposed to diclofenac.
Biochimica et biophysica acta 1995;1272(3):140-6.
1995: Xavier Ponsoda; Ramiro Jover; C Núñez; M Royo; José V Castell; M José Gómez-Lechón
Evaluation of the cytotoxicity of 10 chemicals in human and rat hepatocytes and in cell lines: Correlation between in vitro data and human lethal concentration.
Toxicology in vitro : an international journal published in association with BIBRA 1995;9(6):959-66.
1995: F Boscá; G Carganico; José V Castell; M José Gómez-Lechón; D Hernandez; David Mauleón; L A Martínez; Miguel A Miranda
Evaluation of ketoprofen (R,S and R/S) phototoxicity by a battery of in vitro assays.
Journal of photochemistry and photobiology. B, Biology 1995;31(3):133-8.
1995: M E Herrero; José V Castell
Fluorometric microassay to quantify microsomal epoxide hydrolase in 96-well plates.
Analytical biochemistry 1995;230(1):154-8.
1995: Xavier Ponsoda; Roque Bort; Ramiro Jover; M José Gómez-Lechón; José V Castell
Molecular mechanism of diclofenac hepatotoxicity: Association of cell injury with oxidative metabolism and decrease in ATP levels.
Toxicology in vitro : an international journal published in association with BIBRA 1995;9(4):439-44.
1995: Isabel Guillén; M Blanes; M José Gómez-Lechón; José V Castell
Cytokine signaling during myocardial infarction: sequential appearance of IL-1 beta and IL-6.
The American journal of physiology 1995;269(2 Pt 2):R229-35.
1995: M Teresa Donato; José V Castell; M José Gómez-Lechón
Effect of model inducers on cytochrome P450 activities of human hepatocytes in primary culture.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(5):553-8.
1994: M E Herrero; José V Castell
Quantification of CYP1A1 and 2B1/2 in rat hepatocytes cultured in microwells by immunological methods.
Toxicology in vitro : an international journal published in association with BIBRA 1994;8(6):1167-75.
1994: M Teresa Donato; José V Castell; M José Gómez-Lechón
Cytochrome P450 activities in pure and co-cultured rat hepatocytes. Effects of model inducers.
In vitro cellular & developmental biology. Animal 1994;30A(12):825-32.
1994: José V Castell; M J Gomez-Lechon; D Hernandez; L A Martinez; Miguel A Miranda
Molecular basis of drug phototoxicity: photosensitized cell damage by the major photoproduct of tiaprofenic acid.
Photochemistry and photobiology 1994;60(6):586-90.
1994: M Teresa Donato; Anna Maria Bassi; M José Gómez-Lechón; Silvana Penco; E Herrero; D Adamo; José V Castell; Marinella Ferro
Evaluation of the xenobiotic biotransformation capability of six rodent hepatoma cell lines in comparison with rat hepatocytes.
In vitro cellular & developmental biology. Animal 1994;30A(9):574-80.
1994: Ramiro Jover; Xavier Ponsoda; José V Castell; M José Gómez-Lechón
Acute cytotoxicity of ten chemicals in human and rat cultured hepatocytes and in cell lines: Correlation between in vitro data and human lethal concentrations.
Toxicology in vitro : an international journal published in association with BIBRA 1994;8(1):47-54.
1994: José V Castell; M J Gomez-Lechon; C Grassa; L A Martinez; Miguel A Miranda; P Tarrega
Photodynamic lipid peroxidation by the photosensitizing nonsteroidal antiinflammatory drugs suprofen and tiaprofenic acid.
Photochemistry and photobiology 1994;59(1):35-9.
1993: Ramiro Jover; Xavier Ponsoda; J Gómez-Lechón; José V Castell
Cocaine hepatotoxicity: two different toxicity mechanisms for phenobarbital-induced and non-induced rat hepatocytes.
Biochemical pharmacology 1993;46(11):1967-74.
1993: M Teresa Donato; M José Gómez-Lechón; José V Castell
A microassay for measuring cytochrome P450IA1 and P450IIB1 activities in intact human and rat hepatocytes cultured on 96-well plates.
Analytical biochemistry 1993;213(1):29-33.
1993: Miguel A Miranda; José V Castell; M José Gómez-Lechón; L A Martinez
In vitro photoperoxidation as an indicator of the potential phototoxicity of non-steroidal anti-inflammatory 2-arylpropionic acids.
Toxicology in vitro : an international journal published in association with BIBRA 1993;7(4):523-6.
1993: M Teresa Donato; E Herrero; M José Gómez-Lechón; José V Castell
Inhibition of monooxygenase activities in human hepatocytes by interferons.
Toxicology in vitro : an international journal published in association with BIBRA 1993;7(4):481-5.
1993: José V Castell; M J Gomez-Lechon; C Grassa; L A Martinez; Miguel A Miranda; P Tarrega
Involvement of drug-derived peroxides in the phototoxicity of naproxen and tiaprofenic acid.
Photochemistry and photobiology 1993;57(3):486-90.
1992: M T Donato; F Goethals; M José Gómez-Lechón; D Deboyser; I De Coster; M Roberfroid; José V Castell
Toxicity of the antitumoral drug datelliptium in hepatic cells: Use of models in vitro for the prediction of toxicity in vivo.
Toxicology in vitro : an international journal published in association with BIBRA 1992;6(4):295-302.
1992: José V Castell; M José Gómez-Lechón; Miguel A Miranda; Isabel M Morera
Phototoxicity of non-steroidal anti-inflammatory drugs: in vitro testing of the photoproducts of Butibufen and Flurbiprofen.
Journal of photochemistry and photobiology. B, Biology 1992;13(1):71-81.
1992: Ramiro Jover; Xavier Ponsoda; M José Gómez-Lechón; José V Castell
Potentiation of heroin and methadone hepatotoxicity by ethanol: an in vitro study using cultured human hepatocytes.
Xenobiotica; the fate of foreign compounds in biological systems 1992;22(4):471-8.
1992: Xavier Ponsoda; Ramiro Jover; José V Castell; M José Gómez-Lechón
Potentiation of cocaine hepatotoxicity in human hepatocytes by ethanol.
Toxicology in vitro : an international journal published in association with BIBRA 1992;6(2):155-8.
1992: Ramiro Jover; Xavier Ponsoda; José V Castell; M José Gómez-Lechón
Evaluation of the cytotoxicity of ten chemicals on human cultured hepatocytes: Predictability of human toxicity and comparison with rodent cell culture systems.
Toxicology in vitro : an international journal published in association with BIBRA 1992;6(1):47-52.
1992: A Larrauri; José V Castell; G Garrido; J Berenguer; M José Gómez-Lechón
S-adenosyl-L-methionine reverses the cholestatic effect of ethinylestradiol in rat hepatocytes by increasing its catabolism.
Cell biology and toxicology 1992;8(1):13-26.
1991: Ramiro Jover; Xavier Ponsoda; M José Gómez-Lechón; C Herrero; J del Pino; José V Castell
Potentiation of cocaine hepatotoxicity by ethanol in human hepatocytes.
Toxicology and applied pharmacology 1991;107(3):526-34.
1991: M Pilar López; M José Gómez-Lechón; José V Castell
Role of glucose, insulin, and glucagon in glycogen mobilization in human hepatocytes.
Diabetes 1991;40(2):263-8.
1991: Miguel A Miranda; I Morera; F Vargas; M José Gómez-Lechón; José V Castell
In vitro assessment of the phototoxicity of anti-inflammatory 2-arylpropionic acids.
Toxicology in vitro : an international journal published in association with BIBRA 1991;5(5-6):451-5.
1991: M T Donato; M José Gómez-Lechón; José V Castell
Rat hepatocytes cultured on a monkey kidney cell line: Expression of biotransformation and hepatic metabolic activities.
Toxicology in vitro : an international journal published in association with BIBRA 1991;5(5-6):435-8.
1991: Xavier Ponsoda; Ramiro Jover; M José Gómez-Lechón; Ricardo Fabra; Ramón Trullenque; José V Castell
The effects of buprenorphine on the metabolism of human hepatocytes.
Toxicology in vitro : an international journal published in association with BIBRA 1991;5(3):219-24.
1991: M Teresa Donato; José V Castell; M José Gómez-Lechón
Co-cultures of hepatocytes with epithelial-like cell lines: expression of drug-biotransformation activities by hepatocytes.
Cell biology and toxicology 1991;7(1):1-14.
1991: Xavier Ponsoda; Ramiro Jover; M José Gómez-Lechón; R Fabra; R Trullenque; José V Castell
Intracellular glutathione in human hepatocytes incubated with S-adenosyl-L-methionine and GSH-depleting drugs.
Toxicology 1991;70(3):293-302.
1990: M Teresa Donato; M José Gómez-Lechón; José V Castell
Drug metabolizing enzymes in rat hepatocytes co-cultured with cell lines.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1990;26(11):1057-62.
1990: José V Castell; M José Gómez-Lechón; M David; R Fabra; R Trullenque; Peter C Heinrich
Acute-phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6.
Hepatology (Baltimore, Md.) 1990;12(5):1179-86.
1990: M Teresa Donato; M José Gómez-Lechón; José V Castell
Effect of xenobiotics on monooxygenase activities in cultured human hepatocytes.
Biochemical pharmacology 1990;39(8):1321-6.
1990: Peter C Heinrich; José V Castell; Tilo Andus
Interleukin-6 and the acute phase response.
The Biochemical journal 1990;265(3):621-36.
1990: M Teresa Donato; José V Castell; M José Gómez-Lechón
Prolonged expression of biotransformation activities of rat hepatocytes co-cultured with established cell lines.
Toxicology in vitro : an international journal published in association with BIBRA 1990;4(4-5):461-6.
1990: M José Gómez-Lechón; P López; Teresa Donato; A Montoya; A Larrauri; P Giménez; R Trullenque; R Fabra; José V Castell
Culture of human hepatocytes from small surgical liver biopsies. Biochemical characterization and comparison with in vivo.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1990;26(1):67-74.
1989: José V Castell; M José Gómez-Lechón; M David; Tilo Andus; T Geiger; R Trullenque; R Fabra; Peter C Heinrich
Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes.
FEBS letters 1989;242(2):237-9.
1989: José V Castell; Tilo Andus; D Kunz; Peter C Heinrich
Interleukin-6. The major regulator of acute-phase protein synthesis in man and rat.
Annals of the New York Academy of Sciences 1989;557():87-99; discussion 100-1.
1988: M Cerda; A Jorda; Teresa Barber; José V Castell; J Cabo; J Timoneda
An enzyme immunoassay for the quantitation of rat liver carbamoyl-phosphate synthetase I.
Analytical biochemistry 1988;174(2):687-92.
1988: José V Castell; A Larrauri; M José Gómez-Lechón
A study of the relative hepatotoxicity in vitro of the non-steroidal anti-inflammatory drugs ibuprofen, flurbiprofen and butibufen.
Xenobiotica; the fate of foreign compounds in biological systems 1988;18(6):737-45.
1988: M José Gómez-Lechón; A Montoya; P López; Teresa Donato; A Larrauri; José V Castell
The potential use of cultured hepatocytes in predicting the hepatotoxicity of xenobiotics.
Xenobiotica; the fate of foreign compounds in biological systems 1988;18(6):725-35.
1988: M Pilar López; M José Gómez-Lechón; José V Castell
Active glycolysis and glycogenolysis in early stages of primary cultured hepatocytes. Role of AMP and fructose 2,6-bisphosphate.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1988;24(6):511-7.
1988: José V Castell; M José Gómez-Lechón; M David; T Hirano; T Kishimoto; Peter C Heinrich
Recombinant human interleukin-6 (IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes.
FEBS letters 1988;232(2):347-50.
1988: J Masanet; M José Gómez-Lechón; José V Castell
Hepatic toxicity of paraquat in primary cultures of rat hepatocytes.
Toxicology in vitro : an international journal published in association with BIBRA 1988;2(4):275-82.
1987: José V Castell; M J Gomez; Miguel A Miranda; Isabel M Morera
Photolytic degradation of ibuprofen. Toxicity of the isolated photoproducts on fibroblasts and erythrocytes.
Photochemistry and photobiology 1987;46(6):991-6.
1987: J Gómez-Lechón; José V Castell
Evidence for arrested G2 cell subpopulation in rat liver inducible to mitosis.
Cell and tissue kinetics 1987;20(6):583-90.
1987: M José Gómez-Lechón; Xavier Ponsoda; Ramiro Jover; R Fabra; R Trullenque; José V Castell
Hepatotoxicity of the opioids morphine, heroin, meperidine, and methadone to cultured human hepatocytes.
Molecular toxicology 1987;1(4):453-63.
1987: A Larrauri; R Fabra; M José Gómez-Lechón; R Trullenque; José V Castell
Toxicity of paracetamol in human hepatocytes. Comparison of the protective effects of sulfhydryl compounds acting as glutathione precursors.
Molecular toxicology 1987;1(4):301-11.
1987: José V Castell; M J Gomez; V Mirabet; Miguel A Miranda; Isabel M Morera
Photolytic degradation of benorylate: effects of the photoproducts on cultured hepatocytes.
Journal of pharmaceutical sciences 1987;76(5):374-8.
1987: José V Castell; M José Gómez-Lechón; Miguel A Miranda; Isabel M Morera
Toxic effects of the photoproducts of chlorpromazine on cultured hepatocytes.
Hepatology (Baltimore, Md.) 1987;7(2):349-54.
1985: José V Castell; A Montoya; A Larrauri; P López; J Gómez
Effects of benorylate and impacina on the metabolism of cultured hepatocytes.
Xenobiotica; the fate of foreign compounds in biological systems 1985;15(8-9):743-9.
1985: M J Gomez-Lechon; José V Castell
Enzyme-linked immunosorbent assay to quantify fibronectin.
Analytical biochemistry 1985;145(1):1-8.
1984: M Pilar Lopez-Garcia; M J Gomez-Lechon; José V Castell
Glycogen synthesis in serum-free cultured hepatocytes in response to insulin and dexamethasone.
In vitro 1984;20(12):923-31.