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Marilyn Aardema

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Stefan Pfuhler; Tim Singer; Marilyn Aardema; Shareen H Doak; Rosalie Elespuru; Masamitsu Honma; Micheline Kirsch-Volders; Robert LANDSIEDEL; Mugimane Manjanatha; E Maria Donner; James H Kim
Genotoxicity of nanomaterials: refining strategies and tests for hazard identification.
Marilyn Aardema; Brenda B Barnett; Rodger D Curren; Erica L Dahl; Nicola J Hewitt; Greg C Mun; Stefan Pfuhler
Evaluation of chemicals requiring metabolic activation in the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay.
Philippe Vanparys; Marilyn Aardema; Raffaella Corvi; Laura Gribaldo; Makoto Hayashi; Sebastian Hoffmann; Leonard M Schechtman
Application of in vitro cell transformation assays in regulatory toxicology for pharmaceuticals, chemicals, food products and cosmetics.

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All Publications

2013: Stefan Pfuhler; Tim Singer; Marilyn Aardema; Shareen H Doak; Rosalie Elespuru; Masamitsu Honma; Micheline Kirsch-Volders; Robert LANDSIEDEL; Mugimane Manjanatha; E Maria Donner; James H Kim
Genotoxicity of nanomaterials: refining strategies and tests for hazard identification.
Environmental and molecular mutagenesis 2013;54(4):229-39.
2013: Marilyn Aardema; Brenda B Barnett; Rodger D Curren; Erica L Dahl; Nicola J Hewitt; Greg C Mun; Stefan Pfuhler
Evaluation of chemicals requiring metabolic activation in the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay.
Mutation research 2013;750(1-2):40-9.
2012: Philippe Vanparys; Marilyn Aardema; Raffaella Corvi; Laura Gribaldo; Makoto Hayashi; Sebastian Hoffmann; Leonard M Schechtman
Application of in vitro cell transformation assays in regulatory toxicology for pharmaceuticals, chemicals, food products and cosmetics.
Mutation research 2012;744(1):111-6.
2012: Raffaella Corvi; Laura Gribaldo; Makoto Hayashi; Sebastian Hoffmann; Leonard M Schechtman; Marilyn Aardema; Philippe Vanparys
ECVAM prevalidation study on in vitro cell transformation assays: general outline and conclusions of the study.
Mutation research 2012;744(1):12-9.
2011: Sheila Galloway; Robert Heflich; David Kirkland; Dan D Levy; Elisabeth Lorge; Anthony M Lynch; Daniel Marzin; Takeshi Morita; Maik Schuler; Marilyn Aardema; David A Eastmond; Michael Fellows; Günter Speit
Workshop summary: Top concentration for in vitro mammalian cell genotoxicity assays; and report from working group on toxicity measures and top concentration for in vitro cytogenetics assays (chromosome aberrations and micronucleus).
Mutation research 2011;723(2):77-83.
2011: Micheline Kirsch-Volders; Ilse Decordier; Azeddine Elhajouji; Gina Plas; Marilyn Aardema; Michael Fenech
In vitro genotoxicity testing using the micronucleus assay in cell lines, human lymphocytes and 3D human skin models.
Mutagenesis 2011;26(1):177-84.
2007: Veronique Thybaud; Marilyn Aardema; Daniel Casciano; Vicki Dellarco; Michelle R Embry; B Bhaskar Gollapudi; Makoto Hayashi; Michael P Holsapple; David Jacobson-Kram; Peter Kasper; James T MacGregor; Robert Rees
Relevance and follow-up of positive results in in vitro genetic toxicity assays: an ILSI-HESI initiative.
Mutation research 2007;633(2):67-79.
2007: David Kirkland; Marilyn Aardema; N Banduhn; Carmichael Paul; R Fautz; Jean-Roch Meunier; Stefan Pfuhler
In vitro approaches to develop weight of evidence (WoE) and mode of action (MoA) discussions with positive in vitro genotoxicity results.
Mutagenesis 2007;22(3):161-75.
2007: David Kirkland; Stefan Pfuhler; David Tweats; Marilyn Aardema; Raffaella Corvi; Firouz Darroudi; Azeddine Elhajouji; Hansruedi Glatt; Paul Hastwell; Makoto Hayashi; Peter Kasper; Stephan Kirchner; Anthony Lynch; Daniel Marzin; Daniela Maurici; Jean-Roch Meunier; Lutz Müller; Gerhard J Nohynek; James Parry; Elizabeth Parry; Veronique Thybaud; Raymond R Tice; Jan van Benthem; Philippe Vanparys; Paul White
How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop.
Mutation research 2007;628(1):31-55.
2007: Veronique Thybaud; Marilyn Aardema; J Clements; Kerry L Dearfield; S Galloway; Makoto Hayashi; David Jacobson-Kram; David Kirkland; James T MacGregor; Daniel Marzin; W Ohyama; M Schuler; H Suzuki; Errol Zeiger
Strategy for genotoxicity testing: hazard identification and risk assessment in relation to in vitro testing.
Mutation research 2007;627(1):41-58.
2006: David Kirkland; Marilyn Aardema; Lutz Müller; Hayashi Makoto
Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens II. Further analysis of mammalian cell results, relative predictivity and tumour profiles.
Mutation research 2006;608(1):29-42.
2006: rodger curren; Greg C Mun; David P Gibson; Marilyn Aardema
Development of a method for assessing micronucleus induction in a 3D human skin model (EpiDerm).
Mutation research 2006;607(2):192-204.
2006: Elisabeth Lorge; Veronique Thybaud; Marilyn Aardema; Jo Oliver; Akihiro Wakata; Giocondo Lorenzon; Daniel Marzin
SFTG international collaborative study on in vitro micronucleus test I. General conditions and overall conclusions of the study.
Mutation research 2006;607(1):13-36.
2006: Marilyn Aardema; Ronald D Snyder; Carol Spicer; Katyayini Divi; Takeshi Morita; Robert J Mauthe; David P Gibson; Sandra Soelter; Patrick T Curry; Veronique Thybaud; Giocondo Lorenzon; Daniel Marzin; Elisabeth Lorge
SFTG international collaborative study on in vitro micronucleus test III. Using CHO cells.
Mutation research 2006;607(1):61-87.
2005: Arne Müller; Eric Boitier; Ting Hu; Gregory J Carr; Anne-Céline Le Fèvre; Jean-Pierre Marchandeau; Manoli Flor; Felicia Jefferson; Marilyn Aardema; Veronique Thybaud
Laboratory variability does not preclude identification of biological functions impacted by hydroxyurea.
Environmental and molecular mutagenesis 2005;46(4):221-35.
2005: David Kirkland; Marilyn Aardema; leigh m henderson; Lutz Müller
Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity.
Mutation research 2005;584(1-2):1-256.
2005: Daniela Maurici; Marilyn Aardema; Raffaella Corvi; Marcus Kleber; Cyrille Krul; Christian Laurent; Nicola Loprieno; Markku Pasanen; Stefan Pfuhler; Barry Phillips; David Prentice; Enrico Sabbioni; Tore Sanner; Philippe Vanparys
Carcinogenicity.
Alternatives to laboratory animals : ATLA 2005;33 Suppl 1():177-82.
2005: Daniela Maurici; Marilyn Aardema; Raffaella Corvi; Marcus Kleber; Cyrille Krul; Christian Laurent; Nicola Loprieno; Markku Pasanen; Stefan Pfuhler; Barry Phillips; Enrico Sabbioni; Tore Sanner; Philippe Vanparys
Genotoxicty and mutagenicity.
Alternatives to laboratory animals : ATLA 2005;33 Suppl 1():117-30.
2004: Ting Hu; David P Gibson; Gregory J Carr; Suzanne M Torontali; Jay P Tiesman; Joel G Chaney; Marilyn Aardema
Identification of a gene expression profile that discriminates indirect-acting genotoxins from direct-acting genotoxins.
Mutation research 2004;549(1-2):5-27.
2004: Ronald K Newton; Marilyn Aardema; Jiri Aubrecht
The utility of DNA microarrays for characterizing genotoxicity.
Environmental health perspectives 2004;112(4):420-2.
2003: Micheline Kirsch-Volders; Toshio Sofuni; Marilyn Aardema; Silvio Albertini; David A Eastmond; Michael Fenech; Motoi Ishidate; Stephan Kirchner; Elisabeth Lorge; Takeshi Morita; Hannu Norppa; Jordi Surrallés; Annelies Vanhauwaert; Akihiro Wakata
Report from the in vitro micronucleus assay working group.
Mutation research 2003;540(2):153-63.
2002: Marilyn Aardema; James T MacGregor
Toxicology and genetic toxicology in the new era of "toxicogenomics": impact of "-omics" technologies.
Mutation research 2002;499(1):13-25.
2002: H Murli; Marilyn Aardema; TE Lawlor; C Spicer
Photoclastogenicity-an improved protocol, its validation, and investigation of the photogenotoxicity of DMBA.
Environmental and molecular mutagenesis 2002;40(1):41-9.
2000: L Custer; David P Gibson; Marilyn Aardema; RA LeBoeuf
A refined protocol for conducting the low pH 6.7 Syrian hamster embryo (SHE) cell transformation assay.
Mutation research 2000;455(1-2):129-39.
2000: leigh m henderson; Silvio Albertini; Marilyn Aardema
Thresholds in genotoxicity responses.
Mutation research 2000;464(1):123-8.
2000: Micheline Kirsch-Volders; Marilyn Aardema; Azeddine Elhajouji
Concepts of threshold in mutagenesis and carcinogenesis.
Mutation research 2000;464(1):3-11.
2000: Micheline Kirsch-Volders; Toshio Sofuni; Marilyn Aardema; Silvio Albertini; David A Eastmond; M Fenech; Motoi Ishidate; Elisabeth Lorge; Hannu Norppa; Jordi Surrallés; W von der Hude; Akihiro Wakata
Report from the In Vitro Micronucleus Assay Working Group.
Environmental and molecular mutagenesis 2000;35(3):167-72.
1999: RA LeBoeuf; K A Kerckaert; Marilyn Aardema; Robert J Isfort
Use of Syrian hamster embryo and BALB/c 3T3 cell transformation for assessing the carcinogenic potential of chemicals.
IARC scientific publications 1999;(146):409-25.
1998: Marilyn Aardema; Silvio Albertini; P Arni; leigh m henderson; Micheline Kirsch-Volders; J M Mackay; Awni Sarrif; D A Stringer; R D Taalman
Aneuploidy: a report of an ECETOC task force.
Mutation research 1998;410(1):3-79.
1998: David P Gibson; X Ma; A G Switzer; V A Murphy; Marilyn Aardema
Comparative genotoxicity of quinolone and quinolonyl-lactam antibacterials in the in vitro micronucleus assay in Chinese hamster ovary cells.
Environmental and molecular mutagenesis 1998;31(4):345-51.
1997: David P Gibson; R Brauninger; H S Shaffi; GA Kerckaert; RA LeBoeuf; Robert J Isfort; Marilyn Aardema
Induction of micronuclei in Syrian hamster embryo cells: comparison to results in the SHE cell transformation assay for National Toxicology Program test chemicals.
Mutation research 1997;392(1-2):61-70.
1997: Marilyn Aardema; L L Crosby; David P Gibson; GA Kerckaert; RA LeBoeuf
Aneuploidy and consistent structural chromosome changes associated with transformation of Syrian hamster embryo cells.
Cancer genetics and cytogenetics 1997;96(2):140-50.
1997: Nancy J Gorelick; JL Andrews; David P Gibson; Gregory J Carr; Marilyn Aardema
Evaluation of lacI mutation in germ cells and micronuclei in peripheral blood after treatment of male lacI transgenic mice with ethylnitrosourea, isopropylmethane sulfonate or methylmethane sulfonate.
Mutation research 1997;388(2-3):187-95.
1996: Gary M Williams; Marilyn Aardema; P H Long; E D Thompson; G S Allgood
Genotoxicity and subchronic toxicity studies with heated olestra.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1996;34(10):941-50.
1996: RA LeBoeuf; GA Kerckaert; Marilyn Aardema; David P Gibson; R Brauninger; Robert J Isfort
The pH 6.7 Syrian hamster embryo cell transformation assay for assessing the carcinogenic potential of chemicals.
Mutation research 1996;356(1):85-127.
1996: GA Kerckaert; Robert J Isfort; Gregory J Carr; Marilyn Aardema; RA LeBoeuf
A comprehensive protocol for conducting the Syrian hamster embryo cell transformation assay at pH 6.70.
Mutation research 1996;356(1):65-84.
1996: Marilyn Aardema; Robert J Isfort; E D Thompson; RA LeBoeuf
The low pH Syrian hamster embryo (SHE) cell transformation assay: a revitalized role in carcinogen prediction.
Mutation research 1996;356(1):5-9.
1995: Kevin E Driscoll; Janet M Carter; P T Iype; H L Kumari; L L Crosby; Marilyn Aardema; Robert J Isfort; DB Cody; M H Chestnut; J L Burns
Establishment of immortalized alveolar type II epithelial cell lines from adult rats.
In vitro cellular & developmental biology. Animal 1995;31(7):516-27.
1995: David P Gibson; Marilyn Aardema; GA Kerckaert; Gregory J Carr; R M Brauninger; RA LeBoeuf
Detection of aneuploidy-inducing carcinogens in the Syrian hamster embryo (SHE) cell transformation assay.
Mutation research 1995;343(1):7-24.
1995: R L Binder; Marilyn Aardema; E D Thompson
Benzoyl peroxide: review of experimental carcinogenesis and human safety data.
Progress in clinical and biological research 1995;391():245-94.
1994: S H Robison; M R Odio; E D Thompson; Marilyn Aardema; A L Kraus
Assessment of the in vivo genotoxicity of 2-hydroxy 4-methoxybenzophenone.
Environmental and molecular mutagenesis 1994;23(4):312-7.
1992: K L McCarthy; W C Thomas; Marilyn Aardema; J L Seymour; D L Putman; L L Yang; rodger curren; R Valencia
Genetic toxicology of acrylic acid.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1992;30(6):505-15.
1991: E D Thompson; J L Seymour; Marilyn Aardema; RA LeBoeuf; B L Evans; DB Cody
Lack of genotoxicity of cross-linked acrylate polymers in four short-term genotoxicity assays.
Environmental and molecular mutagenesis 1991;18(3):184-99.
1990: RA LeBoeuf; GA Kerckaert; Marilyn Aardema; David P Gibson
Multistage neoplastic transformation of Syrian hamster embryo cells cultured at pH 6.70.
Cancer research 1990;50(12):3722-9.
1990: RA LeBoeuf; GA Kerckaert; Marilyn Aardema; J A Poiley; R Raineri
Enhanced morphological and neoplastic transformation of Syrian hamster embryo cells cultured at pH 6.70.
Progress in clinical and biological research 1990;340D():219-28.
1989: D W Petersen; J F Powers; Marilyn Aardema; RA LeBoeuf; L A Smith
Acute, distribution, and subchronic toxicological studies of succinate tartrates.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1989;13(1):137-45.
1989: Marilyn Aardema; David P Gibson; RA LeBoeuf
Sodium fluoride-induced chromosome aberrations in different stages of the cell cycle: a proposed mechanism.
Mutation research 1989;223(2):191-203.
1989: E D Thompson; Marilyn Aardema; RA LeBoeuf
Lack of genotoxicity with acrylate polymers in five short-term mutagenicity assays.
Environmental and molecular mutagenesis 1989;14(2):98-106.