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Ronald van Eijk

Research Profile

Disorders

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Oligonucleotide Array Sequence Analysis

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TOP 3
Ronald van Eijk; Hans Morreau; Lisa Stevens; Tom van Wezel
Assessment of a fully automated high-throughput DNA extraction method from formalin-fixed, paraffin-embedded tissue for KRAS, and BRAF somatic mutation analysis.
Remi A Nout; Natalja T Ter Haar; Elzbieta M Van der Steen-Banasik; Ronald van Eijk; Tjalling Bosse; Carien L Creutzberg; Jan J Jobsen; Ina M Jürgenliemk-Schulz; Ludy C H W Lutgens; Vincent T H B M Smit
Improved risk assessment of endometrial cancer by combined analysis of MSI, PI3K-AKT, Wnt/β-catenin and P53 pathway activation.
A Middeldorp; G I Forte; W E Corver; J Wijnen; H Morreau; Ronald van Eijk; M van Puijenbroek; D Ruano; T Caldes; M van Nieuwenhuizen; J Oosting; T van Wezel
Increased frequency of 20q gain and copy-neutral loss of heterozygosity in mismatch repair proficient familial colorectal carcinomas.

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All Publications

2013: Ronald van Eijk; Hans Morreau; Lisa Stevens; Tom van Wezel
Assessment of a fully automated high-throughput DNA extraction method from formalin-fixed, paraffin-embedded tissue for KRAS, and BRAF somatic mutation analysis.
Experimental and molecular pathology 2013;94(1):121-5.
2012: Remi A Nout; Natalja T Ter Haar; Elzbieta M Van der Steen-Banasik; Ronald van Eijk; Tjalling Bosse; Carien L Creutzberg; Jan J Jobsen; Ina M Jürgenliemk-Schulz; Ludy C H W Lutgens; Vincent T H B M Smit
Improved risk assessment of endometrial cancer by combined analysis of MSI, PI3K-AKT, Wnt/β-catenin and P53 pathway activation.
Gynecologic oncology 2012;126(3):466-73.
2012: A Middeldorp; G I Forte; W E Corver; J Wijnen; H Morreau; Ronald van Eijk; M van Puijenbroek; D Ruano; T Caldes; M van Nieuwenhuizen; J Oosting; T van Wezel
Increased frequency of 20q gain and copy-neutral loss of heterozygosity in mismatch repair proficient familial colorectal carcinomas.
International journal of cancer. Journal international du cancer 2012;130(4):837-46.
2012: Willem E Corver; Noel de Miranda; Wietske C E den Hartog; Guido Hovens; Ekaterina S. Jordanova; Ellen Kapiteijn; Anneke Middeldorp; Jan Oosting; Dina Ruano; Jan Smit; Ronald van Eijk; Merlijn P van Nieuwenhuizen; Tom van Wezel; Karin Weijers; Hans Morreau
Genome haploidisation with chromosome 7 retention in oncocytic follicular thyroid carcinoma.
PloS one 2012;7(6):e38287.
2011: Twinkal C Pansuriya; Luca Sangiorgi; Mikel San-Julian; Raf Sciot; Karoly Szuhai; Berkin Toker; Ronald van Eijk; Jolieke G van Oosterwijk; Maayke A J H van Ruler; Tom van Wezel; Sofie L J Verbeke; Miikka Vikkula; Anne-Marie Cleton-Jansen; Pio d'Adamo; Soeren Daugaard; Pim J French; Catherine Godfraind; Lars-Gunnar Kindblom; Marieke L Kuijjer; Kyle C Kurek; Bernadette Liegl-Atzwanger; Nisha Limaye; Daniëlle Meijer; Karolin H Nord; Jan Oosting; Laurence M Boon; Judith Bovee
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome.
Nature genetics 2011;43(12):1256-61.
2011: Arantza Fariña Sarasqueta; Ines J Goossens-Beumer; Peter J K Kuppen; V E P P Lemmens; Hans Morreau; harm rutten; Cornelis J H van de Velde; Ronald van Eijk; Gesina van Lijnschoten; Tom van Wezel; Eliane C M Zeestraten; Jan Willem T Dekker; A J C van den Brule
PIK3CA kinase domain mutation identifies a subgroup of stage III colon cancer patients with poor prognosis.
Cellular oncology (Dordrecht) 2011;34(6):523-31.
2011: Ronald van Eijk; Jappe Licht; Melanie Schrumpf; Mehrdad Talebian Yazdi; Dina Ruano; Giusi I Forte; petra nederlof; Maud Veselic; Klaus F Rabe; Jouke T Annema; Vincent Smit; Hans Morreau; Tom van Wezel
Rapid KRAS, EGFR, BRAF and PIK3CA mutation analysis of fine needle aspirates from non-small-cell lung cancer using allele-specific qPCR.
PloS one 2011;6(3):e17791.
2010: Victor Enciso-Mora; Peter Broderick; Yussanne Ma; Ruth F Jarrett; Henrik Hjalgrim; Kari Hemminki; Anke Van den Berg; Bianca Olver; Amy Lloyd; Sara E Dobbins; Tracy Lightfoot; Flora E van Leeuwen; Asta Försti; Arjan Diepstra; Annegien Broeks; Jayaram Vijayakrishnan; Lesley Shield; Annette Lake; Dorothy Montgomery; Eve Roman; Andreas Engert; Elke Pogge von Strandmann; Katrin S Reiners; Ilja M Nolte; Karin E Smedby; Hans-Olov Adami; Nicola S Russell; Bengt Glimelius; Stephen Hamilton-Dutoit; Marieke de Bruin; lars peter ryder; Daniel Molin; Karina Meden Sorensen; Ellen T Chang; Malcolm Taylor; Rosie Cooke; Robert Hofstra; Helga Westers; Tom van Wezel; Ronald van Eijk; Alan Ashworth; Klaus Rostgaard; Mads Melbye; Anthony J Swerdlow; Richard S Houlston
A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3).
Nature genetics 2010;42(12):1126-30.
2010: Eddy H J van Roon; Marjo Van Puijenbroek; Anneke Middeldorp; Ronald van Eijk; Emile J de Meijer; Dianhdra Erasmus; Kim A D Wouters; Manon van Engeland; Jan Oosting; Frederik J Hes; Carli Tops; Tom van Wezel; Judith M Boer; Hans Morreau
Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition?
BMC cancer 2010;10():180.
2010: Ronald van Eijk; Paul H C Eilers; Remco Natté; Anne-Marie Cleton-Jansen; Hans Morreau; Tom van Wezel; Jan Oosting
MLPAinter for MLPA interpretation: an integrated approach for the analysis, visualisation and data management of Multiplex Ligation-dependent Probe Amplification.
BMC bioinformatics 2010;11():67.
2010: Ronald van Eijk; Marjo Van Puijenbroek; Amiet R Chhatta; Nisha Gupta; Rolf H A M Vossen; Esther H Lips; Anne-Marie Cleton-Jansen; Hans Morreau; Tom van Wezel
Sensitive and specific KRAS somatic mutation analysis on whole-genome amplified DNA from archival tissues.
The Journal of molecular diagnostics : JMD 2010;12(1):27-34.
2009: Anneke Middeldorp; Shantie Jagmohan-Changur; Ronald van Eijk; Carli Tops; Peter Devilee; Hans F A Vasen; Frederik J Hes; Richard Houlston; Ian Tomlinson; Jeanine J Houwing-Duistermaat; Juul Wijnen; Hans Morreau; Tom van Wezel
Enrichment of low penetrance susceptibility loci in a Dutch familial colorectal cancer cohort.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009;18(11):3062-7.
2009: Salvatore Romeo; Maria Debiec-Rychter; Martine Van Glabbeke; Heidi Van Paassen; Paola Comite; Ronald van Eijk; Jan Oosting; Jaap Verweij; Philippe Terrier; Ulrike Schneider; Raf Sciot; Jean Yves Blay; Pancras Hogendoorn
Cell cycle/apoptosis molecule expression correlates with imatinib response in patients with advanced gastrointestinal stromal tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(12):4191-8.
2009: Cristiana E T Da Costa; Karoly Szuhai; Ronald van Eijk; Manja Hoogeboom; Raphael Sciot; Fredrik Mertens; Helga Björgvinsdóttir; Maria Debiec-Rychter; Ronald R de Krijger; Pancras Hogendoorn; R Maarten Egeler; Nicola E Annels
No genomic aberrations in Langerhans cell histiocytosis as assessed by diverse molecular technologies.
Genes, chromosomes & cancer 2009;48(3):239-49.
2009: Maartje Nielsen; Noel F C C de Miranda; Marjo Van Puijenbroek; Ekaterina S. Jordanova; Anneke Middeldorp; Tom van Wezel; Ronald van Eijk; Carli Tops; Hans F A Vasen; Frederik J Hes; Hans Morreau
Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas.
BMC cancer 2009;9():184.
2009: Juul Wijnen; Richard M Brohet; Ronald van Eijk; Shantie Jagmohan-Changur; Anneke Middeldorp; Carli Tops; Mario van Puijenbroek; Margreet G E M Ausems; Encarna Gómez García; Frederik J Hes; Nicoline Hoogerbrugge; Fred H Menko; Theo A M van Os; Rolf Sijmons; Senno Verhoef; Anja Wagner; Fokko M Nagengast; Jan H Kleibeuker; Peter Devilee; Hans Morreau; David Goldgar; Ian P M Tomlinson; richard Houlston; Tom van Wezel; H F A Vasen
Chromosome 8q23.3 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome.
Gastroenterology 2009;136(1):131-7.
2008: Willem E Corver; Anneke Middeldorp; Natalja T ter Haar; Ekaterina S. Jordanova; Marjo van Puijenbroek; Ronald van Eijk; Cees J Cornelisse; Gert Jan Fleuren; Hans Morreau; Jan Oosting; Tom van Wezel
Genome-wide allelic state analysis on flow-sorted tumor fractions provides an accurate measure of chromosomal aberrations.
Cancer research 2008;68(24):10333-40.
2008: A Middeldorp; Marjo Van Puijenbroek; M Nielsen; W E Corver; Ekaterina S. Jordanova; Natalja T Ter Haar; C M J Tops; H F A Vasen; E H Lips; Ronald van Eijk; F J Hes; Jan Oosting; Juul Wijnen; Tom van Wezel; Hans Morreau
High frequency of copy-neutral LOH in MUTYH-associated polyposis carcinomas.
The Journal of pathology 2008;216(1):25-31.
2008: Esther H Lips; Ronald van Eijk; E J R de Graaf; PG Doornebosch; Noel F C C de Miranda; Jan Oosting; Tom Karsten; Paul H C Eilers; R A E M Tollenaar; Tom van Wezel; Hans Morreau
Progression and tumor heterogeneity analysis in early rectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(3):772-81.
2008: Esther H Lips; Ronald van Eijk; E J R de Graaf; Jan Oosting; Noel F C C de Miranda; Tom Karsten; Cornelis J van de Velde; Paul H C Eilers; R A E M Tollenaar; Tom van Wezel; Hans Morreau
Integrating chromosomal aberrations and gene expression profiles to dissect rectal tumorigenesis.
BMC cancer 2008;8():314.
2008: Anne-Marie Cleton-Jansen; Ronald van Eijk; Marcel Lombaerts; Marjanka K Schmidt; Laura J van't Veer; Katja Philippo; Rhyenne M E Zimmerman; Johannes L Peterse; Vincent T B H M Smit; Tom van Wezel; Cees J Cornelisse
ATBF1 and NQO1 as candidate targets for allelic loss at chromosome arm 16q in breast cancer: absence of somatic ATBF1 mutations and no role for the C609T NQO1 polymorphism.
BMC cancer 2008;8():105.
2008: Marjo Van Puijenbroek; Anneke Middeldorp; Carli Tops; Ronald van Eijk; Heleen van der Klift; H F A Vasen; Juul Wijnen; Frederik J Hes; Jan Oosting; Tom van Wezel; Hans Morreau
Genome-wide copy neutral LOH is infrequent in familial and sporadic microsatellite unstable carcinomas.
Familial cancer 2008;7(4):319-30.
2007: Esther H Lips; E J R de Graaf; R A E M Tollenaar; Ronald van Eijk; Jan Oosting; Karoly Szuhai; T Karsten; Y Nanya; S Ogawa; Cornelis J H van de Velde; Paul H C Eilers; Tom van Wezel; Hans Morreau
Single nucleotide polymorphism array analysis of chromosomal instability patterns discriminates rectal adenomas from carcinomas.
The Journal of pathology 2007;212(3):269-77.
2007: Jan Oosting; Esther H Lips; Ronald van Eijk; Paul H C Eilers; Karoly Szuhai; Cisca Wijmenga; Hans Morreau; Tom van Wezel
High-resolution copy number analysis of paraffin-embedded archival tissue using SNP BeadArrays.
Genome research 2007;17(3):368-76.
2006: Marcel Lombaerts; Tom van Wezel; Katja Philippo; Jan Willem F Dierssen; R M E Zimmerman; Jan Oosting; Ronald van Eijk; Paul H C Eilers; Bob van de Water; Cees J Cornelisse; Anne-Marie Cleton-Jansen
E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines.
British journal of cancer 2006;94(5):661-71.
2005: Esther H Lips; Jan Willem F Dierssen; Ronald van Eijk; Jan Oosting; Paul H C Eilers; R A E M Tollenaar; E J R de Graaf; Ruben van't Slot; Cisca Wijmenga; Hans Morreau; Tom van Wezel
Reliable high-throughput genotyping and loss-of-heterozygosity detection in formalin-fixed, paraffin-embedded tumors using single nucleotide polymorphism arrays.
Cancer research 2005;65(22):10188-91.
2005: Marjo Van Puijenbroek; Jan Willem F Dierssen; Patrick Stanssens; Ronald van Eijk; Anne-Marie Cleton-Jansen; Tom van Wezel; Hans Morreau
Mass spectrometry-based loss of heterozygosity analysis of single-nucleotide polymorphism loci in paraffin embedded tumors using the MassEXTEND assay: single-nucleotide polymorphism loss of heterozygosity analysis of the protein tyrosine phosphatase receptor type J in familial colorectal cancer.
The Journal of molecular diagnostics : JMD 2005;7(5):623-30.
2005: Nathalie L G Sieben; Jan Oosting; Adrienne M Flanagan; Jaime Prat; Guido M J M Roemen; Sandra M Kolkman-Uljee; Ronald van Eijk; Cees J Cornelisse; Gert Jan Fleuren; Manon van Engeland
Differential gene expression in ovarian tumors reveals Dusp 4 and Serpina 5 as key regulators for benign behavior of serous borderline tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(29):7257-64.
2005: Remco Natté; Ronald van Eijk; Paul H C Eilers; Anne-Marie Cleton-Jansen; Jan Oosting; Mathilde Kouwenhove; Johan M Kros; Sjoerd G van Duinen
Multiplex ligation-dependent probe amplification for the detection of 1p and 19q chromosomal loss in oligodendroglial tumors.
Brain pathology (Zurich, Switzerland) 2005;15(3):192-7.
2005: Elza C de Bruin; Simone van de Pas; Esther H Lips; Ronald van Eijk; Minke M C van der Zee; Marcel Lombaerts; Tom van Wezel; Corrie A M Marijnen; J H J M van Krieken; Jan Paul Medema; Cornelis J H van de Velde; Paul H C Eilers; Lucy T C Peltenburg
Macrodissection versus microdissection of rectal carcinoma: minor influence of stroma cells to tumor cell gene expression profiles.
BMC genomics 2005;6():142.
2004: Ronald van Eijk; Jan Oosting; Nathalie L G Sieben; Tom van Wezel; Anne-Marie Cleton-Jansen
Visualization of regional gene expression biases by microarray data sorting.
BioTechniques 2004;36(4):592-4, 596.
2001: Gisela M Terwindt; Roel A Ophoff; Ronald van Eijk; Monique N Vergouwe; Joost Haan; Rune R Frants; Lodewijk A Sandkuijl; Michel D Ferrari
Involvement of the CACNA1A gene containing region on 19p13 in migraine with and without aura.
Neurology 2001;56(8):1028-32.
2001: I Stec; Marcel van Vliet; Ronald van Eijk; H Meijers; K H Kroeze; Johannes G Dauwerse; Gert-Jan B van Ommen; Cees J Cornelisse; Johan T den Dunnen; Peter Devilee
A partial BRCA1 sequence homology mapping to 4q28.
Cytogenetics and cell genetics 2001;94(1-2):26-9.
2000: T Peelen; Wiljo J F De Leeuw; K van Lent; Hans Morreau; Ronald van Eijk; Marcel van Vliet; Juul Wijnen; M J L Ligtenberg; HB Ginjaar; R Zweemer; Fred H Menko; Riccardo Fodde; Gert-Jan B van Ommen; H F A Vasen; Cees J Cornelisse; Peter Devilee
Genetic analysis of a breast-ovarian cancer family, with 7 cases of colorectal cancer linked to BRCA1, fails to support a role for BRCA1 in colorectal tumorigenesis.
International journal of cancer. Journal international du cancer 2000;88(5):778-82.
2000: Hadewych Papelard; Geertruida H de Bock; Ronald van Eijk; Theodora P M Vliet Vlieland; Cees J Cornelisse; Peter Devilee; R A E M Tollenaar
Prevalence of BRCA1 in a hospital-based population of Dutch breast cancer patients.
British journal of cancer 2000;83(6):719-24.
2000: M van der Looij; Anne-Marie Cleton-Jansen; Ronald van Eijk; Hans Morreau; Marcel van Vliet; Nel J Kuipers-Dijkshoorn; Edith Oláh; Cees J Cornelisse; Peter Devilee
A sporadic breast tumor with a somatically acquired complex genomic rearrangement in BRCA1.
Genes, chromosomes & cancer 2000;27(3):295-302.
1998: Gisela M Terwindt; Roel A Ophoff; Joost Haan; Monique N Vergouwe; Ronald van Eijk; Rune R Frants; Michel D Ferrari
Variable clinical expression of mutations in the P/Q-type calcium channel gene in familial hemiplegic migraine. Dutch Migraine Genetics Research Group.
Neurology 1998;50(4):1105-10.
1997: A Petrij-Bosch; T Peelen; Marcel van Vliet; Ronald van Eijk; R Olmer; M Drüsedau; Frans B L Hogervorst; S Hageman; PJ Arts; M J L Ligtenberg; Hanne Meijers-Heijboer; Jan G M Klijn; H F A Vasen; Cees J Cornelisse; Laura J van 't Veer; Egbert Bakker; Gert-Jan B van Ommen; Peter Devilee
BRCA1 genomic deletions are major founder mutations in Dutch breast cancer patients.
Nature genetics 1997;17(3):341-5.
1996: Roel A Ophoff; Gisela M Terwindt; Monique N Vergouwe; Ronald van Eijk; P J Oefner; S M Hoffman; Jane Lamerdin; Harvey W Mohrenweiser; D E Bulman; M Ferrari; Joost Haan; Dick Lindhout; Gert-Jan B van Ommen; M H Hofker; Michel D Ferrari; Rune R Frants
Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4.
Cell 1996;87(3):543-52.
1996: Roel A Ophoff; Gisela M Terwindt; Monique N Vergouwe; Ronald van Eijk; Harvey W Mohrenweiser; M Litt; M H Hofker; Joost Haan; Michel D Ferrari; Rune R Frants
A 3-Mb region for the familial hemiplegic migraine locus on 19p13.1-p13.2: exclusion of PRKCSH as a candidate gene. Dutch Migraine Genetic Research Group.
European journal of human genetics : EJHG 1996;4(6):321-8.
1995: Joost Haan; Gisela M Terwindt; Roel A Ophoff; P L Bos; Rune R Frants; Michel D Ferrari; T Krommenhoek; Dick Lindhout; L A Sandkuyl; Ronald van Eijk
Is familial hemiplegic migraine a hereditary form of basilar migraine?
Cephalalgia : an international journal of headache 1995;15(6):477-81.
1995: A May; Roel A Ophoff; Gisela M Terwindt; C Urban; Ronald van Eijk; Joost Haan; H C Diener; Dick Lindhout; Rune R Frants; Lodewijk A Sandkuijl
Familial hemiplegic migraine locus on 19p13 is involved in the common forms of migraine with and without aura.
Human genetics 1995;96(5):604-8.
1995: R H Boerman; Roel A Ophoff; Thera P Links; Ronald van Eijk; Lodewijk A Sandkuijl; Alexis Elbaz; J E Vale-Santos; Axel R Wintzen; Judith C T van Deutekom; D E Isles
Mutation in DHP receptor alpha 1 subunit (CACLN1A3) gene in a Dutch family with hypokalaemic periodic paralysis.
Journal of medical genetics 1995;32(1):44-7.
1994: Roel A Ophoff; Ronald van Eijk; Lodewijk A Sandkuijl; Gisela M Terwindt; C P Grubben; Joost Haan; Dick Lindhout; Michel D Ferrari; Rune R Frants
Genetic heterogeneity of familial hemiplegic migraine.
Genomics 1994;22(1):21-6.
1993: Dorien J M Peters; Lia Spruit; Jasper J Saris; David Ravine; Lodewijk A Sandkuijl; R Fossdal; J Boersma; Ronald van Eijk; S Nørby; C D Constantinou-Deltas
Chromosome 4 localization of a second gene for autosomal dominant polycystic kidney disease.
Nature genetics 1993;5(4):359-62.
1990: Ronald van Eijk; L Chan; B Top; A F Stalenhoef; Louis M Havekes; Rune R Frants
An additional MspI RFLP at the human hepatic lipase (HL) gene locus.
Nucleic acids research 1990;18(10):3110.
1988: Michiel van Lookeren Campagne; C Erneux; Ronald van Eijk; peter van haastert
Two dephosphorylation pathways of inositol 1,4,5-trisphosphate in homogenates of the cellular slime mould Dictyostelium discoideum.
The Biochemical journal 1988;254(2):343-50.
1988: W Spek; K van Drunen; Ronald van Eijk; Pauline Schaap
Opposite effects of adenosine on two types of cAMP-induced gene expression in Dictyostelium indicate the involvement of at least two different intracellular pathways for the transduction of cAMP signals.
FEBS letters 1988;228(2):231-4.