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Lawrence Castellani

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Brian W Parks; Christoph D Rau; Luke K Ursell; Bradley Zinker; Margarete Mehrabian; Elizabeth Nam; Frode Norheim; Elin Org; Calvin Pan; Brian J Bennett; Lawrence W Castellani; Mete Civelek; Thomas A Drake; Christian Andre Drevon; Eleazar Eskin; Peter Gargalovic; Aiqing He; Simon T Hui; Mark Kirby; Todd Kirchgessner; Rob Knight; Emrah Kostem; Aldons J Lusis
Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice.
Juyong Brian Kim; Lawrence W Castellani; Sarada Charugundla; Mete Civelek; Andres Deluna; Hieronim Jakobowski; Imran N Mungrue; Luz Orozco; Delila Pouldar; Marta Rusek; Christine Vu; Xuping Wang; Judy Wu; Aldons J Lusis
Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice.
Cynthia Hong; Aldons J Lusis; Susan Realegeno; Srinivasa T Reddy; Xin Rong; Jon Salazar; Rajendra K Tangirala; Rima Boyadjian; Michelle N Bradley; Lawrence W Castellani; Alan M Fogelman; Victor Grijalva; Brian J Van Lenten; Alan Wagner; Xuping Wang; Peter Tontonoz
LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice.

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All Publications

2013: Brian W Parks; Christoph D Rau; Luke K Ursell; Bradley Zinker; Margarete Mehrabian; Elizabeth Nam; Frode Norheim; Elin Org; Calvin Pan; Brian J Bennett; Lawrence W Castellani; Mete Civelek; Thomas A Drake; Christian Andre Drevon; Eleazar Eskin; Peter Gargalovic; Aiqing He; Simon T Hui; Mark Kirby; Todd Kirchgessner; Rob Knight; Emrah Kostem; Aldons J Lusis
Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice.
Cell metabolism 2013;17(1):141-52.
2012: Juyong Brian Kim; Lawrence W Castellani; Sarada Charugundla; Mete Civelek; Andres Deluna; Hieronim Jakobowski; Imran N Mungrue; Luz Orozco; Delila Pouldar; Marta Rusek; Christine Vu; Xuping Wang; Judy Wu; Aldons J Lusis
Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice.
Circulation 2012;126(15):1896-906.
2012: Cynthia Hong; Aldons J Lusis; Susan Realegeno; Srinivasa T Reddy; Xin Rong; Jon Salazar; Rajendra K Tangirala; Rima Boyadjian; Michelle N Bradley; Lawrence W Castellani; Alan M Fogelman; Victor Grijalva; Brian J Van Lenten; Alan Wagner; Xuping Wang; Peter Tontonoz
LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice.
Journal of lipid research 2012;53(6):1126-33.
2012: Peter Langfelder; Aldons J Lusis; Lawrence W Castellani; Richard Davis; Steve Horvath; Eric Paul; Eric E Schadt; Zhiqiang Zhou; Margarete Mehrabian
A systems genetic analysis of high density lipoprotein metabolism and network preservation across mouse models.
Biochimica et biophysica acta 2012;1821(3):435-47.
2011: Berenice Barajas; Nam Che; Fen Yin; Amir Rowshanrad; Luz D Orozco; Ke Wei Gong; Xuping Wang; Lawrence W Castellani; Karen Reue; Aldons J Lusis; Jesus A Araujo
NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protection.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(1):58-66.
2010: Sulin Wu; Rebecca Mar-Heyming; Eric Z Dugum; Nicholas A Kolaitis; Hongxiu Qi; Päivi Pajukanta; Lawrence W Castellani; Aldons J Lusis; Thomas A Drake
Upstream transcription factor 1 influences plasma lipid and metabolic traits in mice.
Human molecular genetics 2010;19(4):597-608.
2010: Brian J Bennett; Charles Farber; Luz Orozco; Hyun Min Kang; Anatole Ghazalpour; Nathan Siemers; Michael Neubauer; Isaac Neuhaus; Roumyana Yordanova; Bo Guan; Amy Truong; Wen-Pin Yang; Aiqing He; Paul Kayne; Peter Gargalovic; Todd Kirchgessner; Calvin Pan; Lawrence W Castellani; Emrah Kostem; Nicholas Furlotte; Thomas A Drake; Eleazar Eskin; Aldons J Lusis
A high-resolution association mapping panel for the dissection of complex traits in mice.
Genome research 2010;20(2):281-90.
2010: Jennifer M P Woo; Zhuofeng Lin; Mohamad Navab; Casey Van Dyck; Yvette Trejo-Lopez; Krystal M T Woo; Hongyun Li; Lawrence W Castellani; Xuping Wang; Noriko Iikuni; Ornella J Rullo; Hui Wu; Antonio La Cava; Alan M Fogelman; Aldons J Lusis; Betty P Tsao
Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis.
Arthritis research & therapy 2010;12(3):R93.
2010: Michael M Weinstein; Liya Yin; Yiping Tu; Xuping Wang; Xiaohui Wu; Lawrence W Castellani; Rosemary Walzem; Aldons J Lusis; Loren G Fong; Anne P Beigneux; Stephen G Young
Chylomicronemia elicits atherosclerosis in mice--brief report.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(1):20-3.
2008: Margarete Mehrabian; F T Schulthess; M Nebohacova; Lawrence W Castellani; Z Zhou; Jaana Hartiala; José Oberholzer; Aldons J Lusis; Kathrin Maedler; Hooman Allayee
Identification of ALOX5 as a gene regulating adiposity and pancreatic function.
Diabetologia 2008;51(6):978-88.
2008: Nadine S Sauter; Fabienne T Schulthess; Ryan Galasso; Lawrence W Castellani; Kathrin Maedler
The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia.
Endocrinology 2008;149(5):2208-18.
2008: Lawrence W Castellani; Cara N Nguyen; Sarada Charugundla; Michael M Weinstein; Chau X Doan; William S Blaner; Nuttaporn Wongsiriroj; Aldons J Lusis
Apolipoprotein AII is a regulator of very low density lipoprotein metabolism and insulin resistance.
The Journal of biological chemistry 2008;283(17):11633-44.
2007: Xuebing Feng; Hongyun Li; Alexis A Rumbin; Xuping Wang; Antonio La Cava; Katherine Brechtelsbauer; Lawrence W Castellani; Joseph L Witztum; Aldons J Lusis; Betty P Tsao
ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia.
Journal of lipid research 2007;48(4):794-805.
2006: Daria Estrada-Smith; Alan R Collins; Xuping Wang; Craig Crockett; Lawrence W Castellani; Aldons J Lusis; Richard C Davis
Impact of chromosome 2 obesity loci on cardiovascular complications of insulin resistance in LDL receptor-deficient C57BL/6 mice.
Diabetes 2006;55(8):2265-71.
2006: Lawrence W Castellani; James J Chang; Xuping Wang; Aldons J Lusis; Wanda F Reynolds
Transgenic mice express human MPO -463G/A alleles at atherosclerotic lesions, developing hyperlipidemia and obesity in -463G males.
Journal of lipid research 2006;47(7):1366-77.
2005: Margarete Mehrabian; Hooman Allayee; Jirina Stockton; Pek Yee Lum; Thomas A Drake; Lawrence W Castellani; Michael Suh; Christopher Armour; Stephen Wilton Edwards; john lamb; Aldons J Lusis; Eric E Schadt
Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits.
Nature genetics 2005;37(11):1224-33.
2005: Mark O Goodarzi; Howard Wong; Manuel J Quiñones; Kent D Taylor; Xiuqing Guo; Lawrence W Castellani; Heath J Antoine; Huiying Yang; Willa A Hsueh; Jerome I Rotter
The 3' untranslated region of the lipoprotein lipase gene: haplotype structure and association with post-heparin plasma lipase activity.
The Journal of clinical endocrinology and metabolism 2005;90(8):4816-23.
2005: Sonal S Sheth; Lawrence W Castellani; Soumya Chari; Cory Wagg; Christopher K Thipphavong; Jackie S Bodnar; Peter Tontonoz; Alan D Attie; Gary D Lopaschuk; Aldons J Lusis
Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition.
Journal of lipid research 2005;46(1):123-34.
2004: Lawrence W Castellani; Peter Gargalovic; Maria Febbraio; Sarada Charugundla; Ming-Len Jien; Aldons J Lusis
Mechanisms mediating insulin resistance in transgenic mice overexpressing mouse apolipoprotein A-II.
Journal of lipid research 2004;45(12):2377-87.
2004: Xuping Wang; Peter Gargalovic; Jack Wong; Jennifer L Gu; Xiaohui Wu; Hongxiu Qi; Pingzi Wen; Li Xi; Bing Tan; Rocky Gogliotti; Lawrence W Castellani; Aurobindo Chatterjee; Aldons J Lusis
Hyplip2, a new gene for combined hyperlipidemia and increased atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(10):1928-34.
2004: Manuel J Quiñones; Miguel Hernandez-Pampaloni; Heinrich R Schelbert; Isabel Bulnes-Enriquez; Xochitl Jimenez; Gustavo Hernandez; Roxana De La Rosa; Yun Chon; Huiying Yang; Susanne B Nicholas; Tamara Modilevsky; Katherine Yu; Katja Van Herle; Lawrence W Castellani; Robert Elashoff; Willa A Hsueh
Coronary vasomotor abnormalities in insulin-resistant individuals.
Annals of internal medicine 2004;140(9):700-8.
2004: Weibin Shi; Xuping Wang; Jack Wong; Catherine C Hedrick; Howard Wong; Lawrence W Castellani; Aldons J Lusis
Effect of macrophage-derived apolipoprotein E on hyperlipidemia and atherosclerosis of LDLR-deficient mice.
Biochemical and biophysical research communications 2004;317(1):223-9.
2004: Maria C de Beer; Lawrence W Castellani; Lei Cai; Arnold J Stromberg; Frederick C de Beer; Deneys R van der Westhuyzen
ApoA-II modulates the association of HDL with class B scavenger receptors SR-BI and CD36.
Journal of lipid research 2004;45(4):706-15.
2004: Daria Estrada-Smith; Lawrence W Castellani; Howard Wong; Ping-Zi Wen; Aileen Chui; Aldons J Lusis; Richard C Davis
Dissection of multigenic obesity traits in congenic mouse strains.
Mammalian genome : official journal of the International Mammalian Genome Society 2004;15(1):14-22.
2003: Hooman Allayee; Lawrence W Castellani; Rita M Cantor; Tjerk W A de Bruin; Aldons J Lusis
Biochemical and genetic association of plasma apolipoprotein A-II levels with familial combined hyperlipidemia.
Circulation research 2003;92(11):1262-7.
2002: Aaron D Tward; Yu-Rong Xia; Xu-Ping Wang; Yi-Shou Shi; Christina Park; Lawrence W Castellani; Aldons J Lusis; Diana M Shih
Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice.
Circulation 2002;106(4):484-90.
2002: Jackie S Bodnar; Aurobindo Chatterjee; Lawrence W Castellani; David A Ross; Jeffrey Ohmen; James Cavalcoli; Chenyan Wu; Katherine M Dains; Joe Catanese; Michael Chu; Sonal S Sheth; Kanti Charugundla; Peter Demant; David B West; Pieter de Jong; Aldons J Lusis
Positional cloning of the combined hyperlipidemia gene Hyplip1.
Nature genetics 2002;30(1):110-6.
2001: Mohamad Navab; Judith A Berliner; Ganesamoorthy Subbanagounder; Susan Hama; Aldons J Lusis; Lawrence W Castellani; Srinivasa Reddy; Diana M Shih; Weibin Shi; Andrew D Watson; Brian J Van Lenten; Devendra K Vora; Alan M Fogelman
HDL and the inflammatory response induced by LDL-derived oxidized phospholipids.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(4):481-8.
2001: Catherine C Hedrick; Lawrence W Castellani; Howard Wong; Aldons J Lusis
In vivo interactions of apoA-II, apoA-I, and hepatic lipase contributing to HDL structure and antiatherogenic functions.
Journal of lipid research 2001;42(4):563-70.
2001: Päivi Pajukanta; Jackie S Bodnar; Riitta Sallinen; M Chu; T Airaksinen; Q Xiao; Lawrence W Castellani; Sonal S Sheth; Maija Wessman; Aarno Palotie; Janet S Sinsheimer; Peter Demant; Aldons J Lusis; Leena Peltonen
Fine mapping of Hyplip1 and the human homolog, a potential locus for FCHL.
Mammalian genome : official journal of the International Mammalian Genome Society 2001;12(3):238-45.
2001: Lawrence W Castellani; A M Goto; Aldons J Lusis
Studies with apolipoprotein A-II transgenic mice indicate a role for HDLs in adiposity and insulin resistance.
Diabetes 2001;50(3):643-51.
2000: Margarete Mehrabian; Lawrence W Castellani; Ping-Zi Wen; Jack Wong; T Rithaporn; Susan Hama; Greg Hough; D Johnson; J J Albers; Giuliano A Mottino; Joy S Frank; Mohamad Navab; Alan M Fogelman; Aldons J Lusis
Genetic control of HDL levels and composition in an interspecific mouse cross (CAST/Ei x C57BL/6J).
Journal of lipid research 2000;41(12):1936-46.
2000: Diana M Shih; Yu-Rong Xia; Xu-Ping Wang; E Miller; Lawrence W Castellani; Ganesamoorthy Subbanagounder; Hilde Cheroutre; Kym F Faull; Judith A Berliner; Joseph L Witztum; Aldons J Lusis
Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis.
The Journal of biological chemistry 2000;275(23):17527-35.
2000: A Mouzeyan; J Choi; Hooman Allayee; Xuping Wang; Janet S Sinsheimer; Jack Phan; Lawrence W Castellani; Karen Reue; Aldons J Lusis; Richard C Davis
A locus conferring resistance to diet-induced hypercholesterolemia and atherosclerosis on mouse chromosome 2.
Journal of lipid research 2000;41(4):573-82.
1999: BT Ivandic; Lawrence W Castellani; Xu-Ping Wang; Jian-Hua Qiao; Margarete Mehrabian; Mohamad Navab; Alan M Fogelman; David Grass; M E Swanson; Maria C de Beer; Frederick C de Beer; Aldons J Lusis
Role of group II secretory phospholipase A2 in atherosclerosis: 1. Increased atherogenesis and altered lipoproteins in transgenic mice expressing group IIa phospholipase A2.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(5):1284-90.
1999: J L Escary; Henry A Choy; Karen Reue; X P Wang; Lawrence W Castellani; C K Glass; Aldons J Lusis; Michael C Schotz
Paradoxical effect on atherosclerosis of hormone-sensitive lipase overexpression in macrophages.
Journal of lipid research 1999;40(3):397-404.
1998: Diana M Shih; L Gu; Yu-Rong Xia; Mohamad Navab; Wan-Fen Li; Susan Hama; Lawrence W Castellani; Clement E Furlong; Lucio G Costa; Alan M Fogelman; Aldons J Lusis
Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis.
Nature 1998;394(6690):284-7.
1998: Lawrence W Castellani; A Weinreb; Jackie S Bodnar; A M Goto; Mark H Doolittle; Margarete Mehrabian; Peter Demant; Aldons J Lusis
Mapping a gene for combined hyperlipidaemia in a mutant mouse strain.
Nature genetics 1998;18(4):374-7.
1997: Frederick C de Beer; Maria C de Beer; Deneys R van der Westhuyzen; Lawrence W Castellani; Aldons J Lusis; M E Swanson; David Grass
Secretory non-pancreatic phospholipase A2: influence on lipoprotein metabolism.
Journal of lipid research 1997;38(11):2232-9.
1997: Lawrence W Castellani; Mohamad Navab; Brian J Van Lenten; Catherine C Hedrick; Susan Hama; A M Goto; Alan M Fogelman; Aldons J Lusis
Overexpression of apolipoprotein AII in transgenic mice converts high density lipoproteins to proinflammatory particles.
The Journal of clinical investigation 1997;100(2):464-74.
1997: Mohamad Navab; S Hama-Levy; Brian J Van Lenten; Gregg C Fonarow; C J Cardinez; Lawrence W Castellani; Marie-Luise Brennan; Aldons J Lusis; Alan M Fogelman; Bert N La Du
Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio.
The Journal of clinical investigation 1997;99(8):2005-19.
1997: R D Cohen; Lawrence W Castellani; Jian-Hua Qiao; Brian J Van Lenten; Aldons J Lusis; Karen Reue
Reduced aortic lesions and elevated high density lipoprotein levels in transgenic mice overexpressing mouse apolipoprotein A-IV.
The Journal of clinical investigation 1997;99(8):1906-16.
1997: D Machleder; BT Ivandic; C Welch; Lawrence W Castellani; Karen Reue; Aldons J Lusis
Complex genetic control of HDL levels in mice in response to an atherogenic diet. Coordinate regulation of HDL levels and bile acid metabolism.
The Journal of clinical investigation 1997;99(6):1406-19.
1995: D A Purcell-Huynh; A Weinreb; Lawrence W Castellani; Margarete Mehrabian; Mark H Doolittle; A J Lusis
Genetic factors in lipoprotein metabolism. Analysis of a genetic cross between inbred mouse strains NZB/BINJ and SM/J using a complete linkage map approach.
The Journal of clinical investigation 1995;96(4):1845-58.
1993: Catherine C Hedrick; Lawrence W Castellani; Craig H Warden; D L Puppione; A J Lusis
Influence of mouse apolipoprotein A-II on plasma lipoproteins in transgenic mice.
The Journal of biological chemistry 1993;268(27):20676-82.
1993: Craig H Warden; Catherine C Hedrick; Jian-Hua Qiao; Lawrence W Castellani; A J Lusis
Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II.
Science (New York, N.Y.) 1993;261(5120):469-72.
1993: Jian-Hua Qiao; Lawrence W Castellani; Michael C Fishbein; A J Lusis
Immune-complex-mediated vasculitis increases coronary artery lipid accumulation in autoimmune-prone MRL mice.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1993;13(6):932-43.