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fatih uckun

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Precursor Cell Lymphoblastic Leukemia-Lymphoma

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fatih uckun; Sanjive Qazi; Pedro Cahn; Osmond J D'Cruz
Stampidine as a promising antiretroviral drug candidate for pre-exposure prophylaxis against sexually transmitted HIV/AIDS.
Osmond J D'Cruz; Sanjive Qazi; Seang Yiv; fatih uckun
A novel vaginal microbicide containing the rationally designed anti-HIV compound HI-443 (N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea]).
Hong Ma; Gregory H Reaman; Sanjive Qazi; Zahide Ozer; Paul Gaynon; fatih uckun
CD22 Exon 12 deletion is a characteristic genetic defect of therapy-refractory clones in paediatric acute lymphoblastic leukaemia.

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All Publications

2012: fatih uckun; Sanjive Qazi; Pedro Cahn; Osmond J D'Cruz
Stampidine as a promising antiretroviral drug candidate for pre-exposure prophylaxis against sexually transmitted HIV/AIDS.
Expert opinion on investigational drugs 2012;21(4):489-500.
2012: Osmond J D'Cruz; Sanjive Qazi; Seang Yiv; fatih uckun
A novel vaginal microbicide containing the rationally designed anti-HIV compound HI-443 (N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea]).
Expert opinion on investigational drugs 2012;21(3):265-79.
2012: Hong Ma; Gregory H Reaman; Sanjive Qazi; Zahide Ozer; Paul Gaynon; fatih uckun
CD22 Exon 12 deletion is a characteristic genetic defect of therapy-refractory clones in paediatric acute lymphoblastic leukaemia.
British journal of haematology 2012;156(1):89-98.
2011: fatih uckun; Amanda L Garner; Hong Ma; Zahide Ozer; Jason Pitt; Sanjive Qazi; Kim D Janda
Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network.
British journal of haematology 2011;153(6):741-52.
2011: fatih uckun; Lei Sun; Sanjive Qazi; Hong Ma; Zahide Ozer
Recombinant human CD19-ligand protein as a potent anti-leukaemic agent.
British journal of haematology 2011;153(1):15-23.
2011: fatih uckun; Aniee Sarkissian; Ilker Dibirdik; Sanjive Qazi
In vitro and in vivo chemosensitizing activity of LFM-A13, a dual-function inhibitor of Bruton's tyrosine kinase and polo-like kinases, against human leukemic B-cell precursors.
Arzneimittel-Forschung 2011;61(4):252-9.
2011: fatih uckun; Jason Pitt; Sanjive Qazi
JAK3 pathway is constitutively active in B-lineage acute lymphoblastic leukemia.
Expert review of anticancer therapy 2011;11(1):37-48.
2010: fatih uckun; Sanjive Qazi
Bruton's tyrosine kinase as a molecular target in treatment of leukemias and lymphomas as well as inflammatory disorders and autoimmunity.
Expert opinion on therapeutic patents 2010;20(11):1457-70.
2010: fatih uckun; I Dibirdik; S Qazi
Augmentation of the antileukemia potency of total-body irradiation (TBI) by a novel P-site inhibitor of spleen tyrosine kinase (SYK).
Radiation research 2010;174(4):526-31.
2010: fatih uckun; Patricia Goodman; Hong Ma; Ilker Dibirdik; Sanjive Qazi
CD22 EXON 12 deletion as a pathogenic mechanism of human B-precursor leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(39):16852-7.
2010: fatih uckun; Sanjive Qazi
Spleen tyrosine kinase as a molecular target for treatment of leukemias and lymphomas.
Expert review of anticancer therapy 2010;10(9):1407-18.
2010: Sanjive Qazi; fatih uckun
Gene expression profiles of infant acute lymphoblastic leukaemia and its prognostically distinct subsets.
British journal of haematology 2010;149(6):865-73.
2010: fatih uckun; Rauf O Ek; Shyi-Tai Jan; Chun-Lin Chen; Sanjive Qazi
Targeting SYK kinase-dependent anti-apoptotic resistance pathway in B-lineage acute lymphoblastic leukaemia (ALL) cells with a potent SYK inhibitory pentapeptide mimic.
British journal of haematology 2010;149(4):508-17.
2010: fatih uckun; Zahide Ozer; Sanjive Qazi; Lisa Tuel-Ahlgren; Chen Mao
Polo-like-kinase 1 (PLK1) as a molecular target to overcome SYK-mediated resistance of B-lineage acute lymphoblastic leukaemia cells to oxidative stress.
British journal of haematology 2010;148(5):714-25.
2010: fatih uckun; Sanjive Qazi; Hong Ma; Lisa Tuel-Ahlgren; Zahide Ozer
STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(7):2902-7.
2010: fatih uckun; Ilker Dibirdik
Chemoprevention of colorectal cancer by targeting Janus kinase 3 with a rationally designed small molecule inhibitor.
Nutrition and cancer 2010;62(7):968-72.
2010: fatih uckun; Ilker Dibirdik; Sanjive Qazi
Prevention of UVB-induced skin inflammation, genotoxicity, and photocarcinogenesis in mice by WHI-P131, a dual-function inhibitor of Janus kinase 3 and EGF receptor kinase.
Arzneimittel-Forschung 2010;60(4):218-25.
2010: fatih uckun; Ilker Dibirdik; Sanjive Qazi; Seang Yiv
Therapeutic nanoparticle constructs of a JAK3 tyrosine kinase inhibitor against human B-lineage ALL cells.
Arzneimittel-Forschung 2010;60(4):210-7.
2008: Michael E Trigg; Harland N Sather; Gregory H Reaman; David G Tubergen; Peter G Steinherz; Paul S Gaynon; fatih uckun; G Denman Hammond
Ten-year survival of children with acute lymphoblastic leukemia: a report from the Children's Oncology Group.
Leukemia & lymphoma 2008;49(6):1142-54.
2008: Osmond J D'Cruz; fatih uckun
Evaluation of local tolerance of the antiretroviral spermicide (WHI-07)-loaded gel-microemulsion in the porcine female reproductive tract.
Journal of applied toxicology : JAT 2008;28(3):303-14.
2008: Osmond J D'Cruz; fatih uckun
Microbicides for multidrug-resistant and multitropic HIV-1.
Current opinion in investigational drugs (London, England : 2000) 2008;9(2):152-69.
2008: fatih uckun; Heather E Tibbles; ZAHIDE OZER; Sanjive Qazi; Alexei O Vassilev
Anti-inflammatory activity profile of JANEX-1 in preclinical animal models.
Bioorganic & medicinal chemistry 2008;16(3):1287-98.
2008: fatih uckun
Clinical potential of targeting Bruton's tyrosine kinase.
International reviews of immunology 2008;27(1-2):43-69.
2007: fatih uckun
Chemosensitizing anti-cancer activity of LFM-A13, a leflunomide metabolite analog targeting polo-like kinases.
Cell cycle (Georgetown, Tex.) 2007;6(24):3021-6.
2007: Osmond J D'Cruz; fatih uckun
Preclinical evaluation of a dual-acting microbicidal prodrug WHI-07 in combination with vanadocene dithiocarbamate in the female reproductive tract of rabbit, pig, and cat.
Toxicologic pathology 2007;35(7):910-27.
2007: fatih uckun; Heather E Tibbles; Alexei O Vassilev
Bruton's tyrosine kinase as a new therapeutic target.
Anti-cancer agents in medicinal chemistry 2007;7(6):624-32.
2007: fatih uckun; Alexei O Vassilev; Ilker Dibirdik; Heather E Tibbles
Targeting JAK3 tyrosine kinase-linked signal transduction pathways with rationally-designed inhibitors.
Anti-cancer agents in medicinal chemistry 2007;7(6):612-23.
2007: fatih uckun; Alexei O Vassilev; Heather E Tibbles
Non-receptor tyrosine kinases as molecular targets for patient tailored cancer therapy.
Anti-cancer agents in medicinal chemistry 2007;7(6):593.
2007: Osmond J D'Cruz; fatih uckun
Mucosal safety of PHI-443 and stampidine as a combination microbicide to prevent genital transmission of HIV-1.
Fertility and sterility 2007;88(4 Suppl):1197-206.
2007: Osmond J D'Cruz; fatih uckun
Targeting mast cells in endometriosis with janus kinase 3 inhibitor, JANEX-1.
American journal of reproductive immunology (New York, N.Y. : 1989) 2007;58(2):75-97.
2007: Osmond J D'Cruz; fatih uckun
Limitations of the human-PBL-SCID mouse model for vaginal transmission of HIV-1.
American journal of reproductive immunology (New York, N.Y. : 1989) 2007;57(5):353-60.
2007: fatih uckun; ZAHIDE OZER; Alexei O Vassilev
Bruton's tyrosine kinase prevents activation of the anti-apoptotic transcription factor STAT3 and promotes apoptosis in neoplastic B-cells and B-cell precursors exposed to oxidative stress.
British journal of haematology 2007;136(4):574-89.
2007: fatih uckun; Ilker Dibirdik; Sanjive Qazi; Alexei O Vassilev; Hong Ma; Chen Mao; Alexey Benyumov; Katayoon H Emami
Anti-breast cancer activity of LFM-A13, a potent inhibitor of Polo-like kinase (PLK).
Bioorganic & medicinal chemistry 2007;15(2):800-14.
2007: fatih uckun; Heather E Tibbles; Taracad K Venkatachalam; Douglas Erbeck
In vivo pharmacokinetics, metabolism, toxicity, and anti-HIV activity of N'-[2-(2-Thiophene)ethyl]-N'-[2-(5-bromopyridyl)]thiourea (HI-443), a potent non-nucleoside inhibitor of HIV reverse transcriptase.
Arzneimittel-Forschung 2007;57(7):483-96.
2007: Darin DuMez; Taracad K Venkatachalam; fatih uckun
Large-scale synthesis of GMP grade N'- [2-(2-thiophene) ethyl]-N'- [2- (5-bromopyridyl)] -thiourea (HI-443), a new anti-HIV drug candidate.
Arzneimittel-Forschung 2007;57(6):330-8.
2007: fatih uckun; Douglas Erbeck; Sanjive Qazi; Taracad K Venkatachalam; Heather E Tibbles; Alexei O Vassilev
Effect of targeting janus kinase 3 on the development of intestinal tumors in the adenomatous polyposis coli(min) mouse model of familial adenomatous polyposis.
Arzneimittel-Forschung 2007;57(6):320-9.
2007: fatih uckun; Sanjive Qazi; Taracad K Venkatachalam
N'-[2-(2-thiophene) ethyl]-N'-[2-(5-bromopyridyl)]thiourea (HI-443), a rationally designed non-nucleoside reverse transcriptase inhibitor compound with potent anti-HIV activity.
Arzneimittel-Forschung 2007;57(5):278-85.
2007: fatih uckun; Heather E Tibbles; Douglas Erbeck; Taracad K Venkatachalam; Sanjive Qazi
In vivo pharmacokinetics and toxicity of a novel hydrophilic oral formulation of the potent non-nucleoside reverse transcriptase inhibitor compound N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea (HI-443).
Arzneimittel-Forschung 2007;57(4):218-26.
2007: Sanjive Qazi; Darin DuMez; fatih uckun
Meta analysis of advanced cancer survival data using lognormal parametric fitting: a statistical method to identify effective treatment protocols.
Current pharmaceutical design 2007;13(15):1533-44.
2007: fatih uckun; Douglas Erbeck; Heather E Tibbles; Sanjive Qazi; Taracad K Venkatachalam
Improved oral bioavailability of anti-HIV agent N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea (HI-443) in a novel lipophilic formulation.
Arzneimittel-Forschung 2007;57(3):164-70.
2007: Darin DuMez; Taracad K Venkatachalam; fatih uckun
Large-scale synthesis of GMP grade alpha-cyano-beta-hydroxy-beta-methyl-N-(2,5-dibromophenyl) propenamide (LFM-A13), a new anti-cancer drug candidate.
Arzneimittel-Forschung 2007;57(3):155-63.
2007: fatih uckun; Darin DuMez; Sanjive Qazi; Heather E Tibbles; Taracad K Venkatachalam
Anti-retroviral activity of GMP-grade stampidine against genotypically and phenotypically nucleoside reverse transcriptase inhibitor resistant recombinant human immunodeficiency virus. An in vitro study.
Arzneimittel-Forschung 2007;57(2):112-21.
2007: fatih uckun; Heather E Tibbles; Taracad K Venkatachalam; Darin DuMez; Douglas Erbeck
Preclinical toxicity and pharmacokinetics of the Bruton's tyrosine kinase-targeting anti-leukemic drug candidate, alpha-cyano-beta-hydroxy-beta-methyl-N- (2,5-dibromophenyl) propenamide (LFM-A13).
Arzneimittel-Forschung 2007;57(1):31-46.
2006: fatih uckun; Sanda Morar; Sanjive Qazi
Vinorelbine-based salvage chemotherapy for therapy-refractory aggressive leukaemias.
British journal of haematology 2006;135(4):500-8.
2006: Taracad K Venkatachalam; M Sarquis; Sanjive Qazi; fatih uckun
Effect of alkyl groups on the cellular hydrolysis of stavudine phosphoramidates.
Bioorganic & medicinal chemistry 2006;14(18):6420-33.
2006: Osmond J D'Cruz; fatih uckun
Novel tight binding PETT, HEPT and DABO-based non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Journal of enzyme inhibition and medicinal chemistry 2006;21(4):329-50.
2006: Taracad K Venkatachalam; Sanjive Qazi; fatih uckun
Synthesis and metabolism of naphthyl substituted phosphoramidate derivatives of stavudine.
Bioorganic & medicinal chemistry 2006;14(15):5161-77.
2006: Osmond J D'Cruz; fatih uckun
Novel broad-spectrum thiourea non-nucleoside inhibitors for the prevention of mucosal HIV transmission.
Current HIV research 2006;4(3):329-45.
2006: Alexei O Vassilev; Heather E Tibbles; Darin DuMez; Taracad K Venkatachalam; fatih uckun
Targeting JAK3 and BTK tyrosine kinases with rationally-designed inhibitors.
Current drug targets 2006;7(3):327-43.
2006: Osmond J D'Cruz; fatih uckun
Dawn of non-nucleoside inhibitor-based anti-HIV microbicides.
The Journal of antimicrobial chemotherapy 2006;57(3):411-23.
2006: fatih uckun; Taracad K Venkatachalam; Sanjive Qazi
Potency of stampidine against multi-nucleoside reverse transcriptase inhibitor resistant human immunodeficiency viruses.
Arzneimittel-Forschung 2006;56(2A):193-203.
2006: fatih uckun; Barbara Waurzyniak; Heather E Tibbles; Taracad K Venkatachalam; Douglas Erbeck
In vivo pharmacokinetics and toxicity profile of the anti-HIV agent stampidine in dogs and feline immunodeficiency virus-infected cats.
Arzneimittel-Forschung 2006;56(2A):176-92.
2006: Taracad K Venkatachalam; Sanjive Qazi; fatih uckun
Site-specific enzymatic activation of the anti-HIV agent stampidine.
Arzneimittel-Forschung 2006;56(2A):167-75.
2006: Osmond J D'Cruz; Douglas Erbeck; fatih uckun
Developmental safety profile of the anti-HIV agent stampidine in rabbits.
Arzneimittel-Forschung 2006;56(2A):159-66.
2006: Taracad K Venkatachalam; Sanjive Qazi; fatih uckun
Synthesis, separation and anti-HIV activity of distereoisomers of N-[p-(4-bromophenyl) -2',3'-didehydro-3'-deoxy-5'-thymidylyl]-L-alanine methyl ester (stampidine).
Arzneimittel-Forschung 2006;56(2A):152-8.
2006: Darin DuMez; Taracad K Venkatachalam; fatih uckun
Large-scale synthesis and formulation of GMP-grade stampidine, a new anti-HIV agent.
Arzneimittel-Forschung 2006;56(2A):136-51.
2006: fatih uckun
Stampidine as a novel nucleoside reverse transcriptase inhibit with potent anti-HIV activity.
Arzneimittel-Forschung 2006;56(2A):121-35.
2006: fatih uckun
Unmet challenges in HIV therapy and potential of stampidine.
Arzneimittel-Forschung 2006;56(2A):117-20.
2006: Osmond J D'Cruz; fatih uckun
Influence of long-term stability conditions on microbicidal nucleoside prodrug (WHI-07)-loaded gel-microemulsion.
AAPS PharmSciTech 2006;7(3):73.
2006: Kathleen Lundell; Sanjive Qazi; Linda Eddy; fatih uckun
Clinical activity of folinic acid in patients with chronic fatigue syndrome.
Arzneimittel-Forschung 2006;56(6):399-404.
2005: Osmond J D'Cruz; fatih uckun
Discovery of 2,5-dimethoxy-substituted 5-bromopyridyl thiourea (PHI-236) as a potent broad-spectrum anti-human immunodeficiency virus microbicide.
Molecular human reproduction 2005;11(10):767-77.
2005: Taracad K Venkatachalam; Peter Samuel; Sanjive Qazi; fatih uckun
Effect of change in nucleoside structure on the activation and antiviral activity of phosphoramidate derivatives.
Bioorganic & medicinal chemistry 2005;13(18):5408-23.
2005: Osmond J D'Cruz; fatih uckun
Vaginal contraceptive activity of a chelated vanadocene.
Contraception 2005;72(2):146-56.
2005: Osmond J D'Cruz; fatih uckun
Stampidine: a selective oculo-genital microbicide.
The Journal of antimicrobial chemotherapy 2005;56(1):10-9.
2005: fatih uckun; Taracad K Venkatachalam; Douglas Erbeck; Chun-Lin Chen; A S Petkevich; Alexei O Vassilev
Zidampidine, an aryl phosphate derivative of AZT: in vivo pharmacokinetics, metabolism, toxicity, and anti-viral efficacy against hemorrhagic fever caused by Lassa virus.
Bioorganic & medicinal chemistry 2005;13(9):3279-88.
2005: Taracad K Venkatachalam; Peter Samuel; Sanjive Qazi; fatih uckun
Protease-mediated enzymatic hydrolysis and activation of aryl phosphoramidate derivatives of stavudine.
European journal of medicinal chemistry 2005;40(5):452-66.
2005: Taracad K Venkatachalam; Peter Samuel; fatih uckun
Enzymatic hydrolysis of stampidine and other stavudine phosphoramidates in the presence of mammalian proteases.
Bioorganic & medicinal chemistry 2005;13(7):2651-5.
2005: Marina Cetkovic-Cvrlje; fatih uckun
Effect of targeted disruption of signal transducer and activator of transcription (Stat)4 and Stat6 genes on the autoimmune diabetes development induced by multiple low doses of streptozotocin.
Clinical immunology (Orlando, Fla.) 2005;114(3):299-306.
2005: Taracad K Venkatachalam; P Samuel; fatih uckun
Stereochemical influence on lipase-mediated hydrolysis and biological activity of stampidine and other stavudine phosphoramidates.
Bioorganic & medicinal chemistry 2005;13(5):1763-73.
2005: fatih uckun; Larisa Rustamova; Alexei O Vassilev; Heather E Tibbles; Alexander S Petkevich
CNS activity of Pokeweed anti-viral protein (PAP) in mice infected with lymphocytic choriomeningitis virus (LCMV).
BMC infectious diseases 2005;5():9.
2005: Osmond J D'Cruz; Peter Samuel; fatih uckun
Conceival, a novel noncontraceptive vaginal vehicle for lipophilic microbicides.
AAPS PharmSciTech 2005;6(1):E56-64.
2005: Osmond J D'Cruz; Douglas Erbeck; fatih uckun
A study of the potential of the pig as a model for the vaginal irritancy of benzalkonium chloride in comparison to the nonirritant microbicide PHI-443 and the spermicide vanadocene dithiocarbamate.
Toxicologic pathology 2005;33(4):465-76.
2005: fatih uckun; Sanjive Qazi; Taracad K Venkatachalam
In vitro anti-HIV potency of stampidine alone and in combination with standard anti-HIV drugs.
Arzneimittel-Forschung 2005;55(4):223-31.
2005: Alexey O Benyumov; Taracad K Venkatachalam; Olga O Grigoriants; Alexei O Vassilev; Heather E Tibbles; Suzanne Downs; Darin Dumezb; fatih uckun
Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds. Studies using human acute lymphoblastic leukemia cells and the zebrafish model.
Arzneimittel-Forschung 2005;55(2):114-22.
2005: fatih uckun; Hung-Liang Tai; Osmond J D'Cruz
Antileukemic activity and cellular metabolism of the aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07).
Arzneimittel-Forschung 2005;55(1):50-65.
2004: Osmond J D'Cruz; Peter Samuel; fatih uckun
PHI-443: a novel noncontraceptive broad-spectrum anti-human immunodeficiency virus microbicide.
Biology of reproduction 2004;71(6):2037-47.
2004: Marina Cetkovic-Cvrlje; fatih uckun
Dual targeting of Bruton's tyrosine kinase and Janus kinase 3 with rationally designed inhibitors prevents graft-versus-host disease (GVHD) in a murine allogeneic bone marrow transplantation model.
British journal of haematology 2004;126(6):821-7.
2004: Taracad K Venkatachalam; G Yu; Peter Samuel; Sanjive Qazi; Sharon Pendergrass; fatih uckun
A comparative study of the hydrolysis pathways of substituted aryl phosphoramidate versus aryl thiophosphoramidate derivatives of stavudine.
European journal of medicinal chemistry 2004;39(8):665-83.
2004: Taracad K Venkatachalam; C Mao; fatih uckun
Effect of stereochemistry on the anti-HIV activity of chiral thiourea compounds.
Bioorganic & medicinal chemistry 2004;12(15):4275-84.
2004: Taracad K Venkatachalam; Peter Samuel; G Li; Sanjive Qazi; Chen Mao; Sharon Pendergrass; fatih uckun
Lipase-mediated stereoselective hydrolysis of stampidine and other phosphoramidate derivatives of stavudine.
Bioorganic & medicinal chemistry 2004;12(12):3371-81.
2004: fatih uckun; Alexander S Petkevich; Alexei O Vassilev; Heather E Tibbles; Leonid Titov
Correction: Stampidine prevents mortality in an experimental mouse model of viral hemorrhagic fever caused by lassa virus.
BMC infectious diseases 2004;4():14.
2004: Taracad K Venkatachalam; Chen Mao; fatih uckun
Effect of stereo and regiochemistry towards wild and multidrug resistant HIV-1 virus: viral potency of chiral PETT derivatives.
Biochemical pharmacology 2004;67(10):1933-46.
2004: Nyla A Heerema; James B Nachman; Harland Sather; Mei K La; Raymond J Hutchinson; Beverly J Lange; Bruce C Bostrom; Peter G Steinherz; Paul S Gaynon; fatih uckun
Deletion of 7p or monosomy 7 in pediatric acute lymphoblastic leukemia is an adverse prognostic factor: a report from the Children's Cancer Group.
Leukemia 2004;18(5):939-47.
2004: Osmond J D'Cruz; Barbara Waurzyniak; fatih uckun
Antiretroviral spermicide WHI-07 prevents vaginal and rectal transmission of feline immunodeficiency virus in domestic cats.
Antimicrobial agents and chemotherapy 2004;48(4):1082-8.
2004: Osmond J D'Cruz; Barbara Waurzyniak; fatih uckun
Mucosal toxicity studies of a gel formulation of native pokeweed antiviral protein.
Toxicologic pathology 2004;32(2):212-21.
2004: Marina Cetkovic-Cvrlje; fatih uckun
Targeting Janus kinase 3 in the treatment of leukemia and inflammatory diseases.
Archivum immunologiae et therapiae experimentalis 2004;52(2):69-82.
2004: fatih uckun; Sharon Pendergrass; Sanjive Qazi; Peter Samuel; Taracad K Venkatachalam
Phenyl phosphoramidate derivatives of stavudine as anti-HIV agents with potent and selective in-vitro antiviral activity against adenovirus.
European journal of medicinal chemistry 2004;39(3):225-34.
2004: Osmond J D'Cruz; fatih uckun
Stampidine is a potential nonspermicidal broad-spectrum anti-human immunodeficiency virus microbicide.
Fertility and sterility 2004;81 Suppl 1():831-41.
2004: fatih uckun; Alexander S Petkevich; Alexei O Vassilev; Heather E Tibbles; Leonid Titov
Stampidine prevents mortality in an experimental mouse model of viral hemorrhagic fever caused by lassa virus.
BMC infectious diseases 2004;4():1.
2004: fatih uckun; Chun-Lin Chen; Xing-Ping Liu; Ilker Dibirdik; Taracad K Venkatachalam
In vitro and in vivo pharmacokinetic features and metabolism of the novel cytotoxic nucleoside analog 3'-azidothymidine 5'-[p-methoxyphenyl methoxyalaninyl phosphate] (Compound 003).
Arzneimittel-Forschung 2004;54(11):732-45.
2004: fatih uckun; Alexei O Vassilev; Ilker Dibirdik; Xing-Ping Liu; Douglas Erbeck; Heather E Tibbles; Sanjive Qazi; Taracad K Venkatachalam
Anti-cancer activity profile of 3'-azidothymidine 5'-[p-methoxyphenyl methoxyalaninyl phosphate] (Compound 003), a novel nucleoside analog.
Arzneimittel-Forschung 2004;54(11):715-31.
2004: Igor V Kurinov; Francis Rajamohan; fatih uckun
High resolution X-ray structure and potent anti-HIV activity of recombinant dianthin antiviral protein.
Arzneimittel-Forschung 2004;54(10):692-702.
2004: Heather E Tibbles; Peter Samuel; Douglas Erbeck; Sandeep Mahajan; fatih uckun
In vivo toxicity and antithrombotic profile of the oral formulation of the antileukemic agent, LFM-A13-F.
Arzneimittel-Forschung 2004;54(6):330-9.
2004: Osmond J D'Cruz; B Waurzyniakt; fatih uckun
A 13-week subchronic intravaginal toxicity study of pokeweed antiviral protein in mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2004;11(4):342-51.
2004: A O Vassilev; fatih uckun
Therapeutic potential of inhibiting Bruton's tyrosine kinase, (BTK).
Current pharmaceutical design 2004;10(15):1757-66.
2004: T K Venkatachalam; P A Goodman; S Qazi; O D'Cruz; fatih uckun
Rational drug design of multifunctional phosphoramidate substituted nucleoside analogs.
Current pharmaceutical design 2004;10(15):1713-26.
2004: fatih uckun; Chen Mao
Tyrosine kinases as new molecular targets in treatment of inflammatory disorders and leukemia.
Current pharmaceutical design 2004;10(10):1083-91.
2004: fatih uckun; Sharon Pendergrass; Sanjive Qazi; Taracad K Venkatachalam
In vitro activity of stampidine against primary clinical human immunodeficiency virus isolates.
Arzneimittel-Forschung 2004;54(1):69-77.
2004: Osmond J D'Cruz; fatih uckun
Clinical development of microbicides for the prevention of HIV infection.
Current pharmaceutical design 2004;10(3):315-36.
2003: Osmond J D'Cruz; Peter Samuel; Barbara Waurzyniak; fatih uckun
Development and evaluation of a thermoreversible ovule formulation of stampidine, a novel nonspermicidal broad-spectrum anti-human immunodeficiency virus microbicide.
Biology of reproduction 2003;69(6):1843-51.
2003: Osmond J D'Cruz; Douglas Erbeck; fatih uckun
Developmental toxicology studies of WHI-07, a novel nucleoside analogue-based dual-function microbicide, administered intravaginally to rabbits.
Toxicologic pathology 2003;31(6):698-708.
2003: fatih uckun; Alexei O Vassilev; Steve Bartell; Yaguo Zheng; Sandeep Mahajan; Heather E Tibbles
The anti-leukemic Bruton's tyrosine kinase inhibitor alpha-cyano-beta-hydroxy-beta-methyl-N-(2,5-dibromophenyl) propenamide (LFM-A13) prevents fatal thromboembolism.
Leukemia & lymphoma 2003;44(9):1569-77.
2003: Adam Levy; Harland Sather; Peter G Steinherz; Rebecca Sowers; Mei K La; Jeffrey A Moscow; Paul S Gaynon; fatih uckun; Joseph R Bertino; Richard Gorlick
Reduced folate carrier and dihydrofolate reductase expression in acute lymphocytic leukemia may predict outcome: a Children's Cancer Group Study.
Journal of pediatric hematology/oncology 2003;25(9):688-95.
2003: Patricia A Goodman; Carla M Wood; Alexei O Vassilev; Chen Mao; fatih uckun
Defective expression of Bruton's tyrosine kinase in acute lymphoblastic leukemia.
Leukemia & lymphoma 2003;44(6):1011-8.
2003: Igor V Kurinov; fatih uckun
High resolution X-ray structure of potent anti-HIV pokeweed antiviral protein-III.
Biochemical pharmacology 2003;65(10):1709-17.
2003: Ursula R Kees; Nyla A Heerema; R Kumar; Paul M Watt; David L Baker; Mei K La; fatih uckun; Harland Sather
Expression of HOX11 in childhood T-lineage acute lymphoblastic leukaemia can occur in the absence of cytogenetic aberration at 10q24: a study from the Children's Cancer Group (CCG).
Leukemia 2003;17(5):887-93.
2003: Patricia A Goodman; Nicole Burkhardt; Brian Juran; Heather E Tibbles; fatih uckun
Hypermethylation of the spleen tyrosine kinase promoter in T-lineage acute lymphoblastic leukemia.
Oncogene 2003;22(16):2504-14.
2003: Osmond J D'Cruz; fatih uckun
Contraceptive activity of a spermicidal aryl phosphate derivative of bromo-methoxy-zidovudine (compound WHI-07) in rabbits.
Fertility and sterility 2003;79(4):864-72.
2003: fatih uckun; Chun-Lin Chen; Peter Samuel; Sharon Pendergrass; Taracad K Venkatachalam; Barbara Waurzyniak; Sanjive Qazi
In vivo antiretroviral activity of stampidine in chronically feline immunodeficiency virus-infected cats.
Antimicrobial agents and chemotherapy 2003;47(4):1233-40.
2003: Taracad K Venkatachalam; Sanjive Qazi; Peter Samuel; fatih uckun
Substituted heterocyclic thiourea compounds as a new class of anti-allergic agents inhibiting IgE/Fc epsilon RI receptor mediated mast cell leukotriene release.
Bioorganic & medicinal chemistry 2003;11(6):1095-105.
2003: Osmond J D'Cruz; Yanhong Dong; fatih uckun
Potent dual anti-HIV and spermicidal activities of novel oxovanadium(V) complexes with thiourea non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Biochemical and biophysical research communications 2003;302(2):253-64.
2003: Marina Cetkovic-Cvrlje; Angela L Dragt; Alexei O Vassilev; Xing-Ping Liu; fatih uckun
Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice.
Clinical immunology (Orlando, Fla.) 2003;106(3):213-25.
2003: Carla M Wood; Patricia A Goodman; Alexei O Vassilev; fatih uckun
CD95 (APO-1/FAS) deficiency in infant acute lymphoblastic leukemia: detection of novel soluble Fas splice variants.
European journal of haematology 2003;70(3):156-71.
2003: fatih uckun; Francis Rajamohan; Sharon Pendergrass; ZAHIDE OZER; Barbara Waurzyniak; Chen Mao
Structure-based design and engineering of a nontoxic recombinant pokeweed antiviral protein with potent anti-human immunodeficiency virus activity.
Antimicrobial agents and chemotherapy 2003;47(3):1052-61.
2003: Sanjive Qazi; N K Peter Samuel; T K Venkatachalam; fatih uckun
Evaluating dissolution profiles of an anti-HIV agent using ANOVA and non-linear regression models in JMP software.
International journal of pharmaceutics 2003;252(1-2):27-39.
2003: Xing-Ping Liu; Rama Krishna Narla; fatih uckun
Organic phenyl arsonic acid compounds with potent antileukemic activity.
Bioorganic & medicinal chemistry letters 2003;13(3):581-3.
2003: Taracad K Venkatachalam; Sanjive Qazi; Peter Samuel; fatih uckun
Inhibition of mast cell leukotriene release by thiourea derivatives.
Bioorganic & medicinal chemistry letters 2003;13(3):485-8.
2003: Marina Cetkovic-Cvrlje; Angela L Dragt; fatih uckun
Prevention of islet allograft rejection in diabetic mice by targeting Janus Kinase 3 with 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (JANEX-1).
Arzneimittel-Forschung 2003;53(9):648-54.
2003: Osmond J D'Cruz; fatih uckun
Contraceptive activity of a spermicidal aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI-05) in rabbits.
Arzneimittel-Forschung 2003;53(7):515-21.
2003: fatih uckun; Osmond J D'Cruz; Xing-Ping Liu; Rama Krishna Narla
Phenylarsonic acid compounds with broad-spectrum and potent cytotoxic activity against human cancer cells.
Arzneimittel-Forschung 2003;53(6):428-39.
2003: fatih uckun; Chun-Lin Chen; Elizabeth Lisowski; Greg C Mitcheltree; Taracad K Venkatachalam; Douglas Erbeck; Hao Chen; Barbara Waurzyniak
Toxicity and pharmacokinetics of stampidine in mice and rats.
Arzneimittel-Forschung 2003;53(5):357-67.
2002: Carla M Wood; Patricia A Goodman; fatih uckun
Jak3 expression and genomic sequence in pediatric acute lymphoblastic leukemia.
Leukemia & lymphoma 2002;43(12):2355-62.
2002: Osmond J D'Cruz; fatih uckun
Pre-clinical safety evaluation of novel nucleoside analogue-based dual-function microbicides (WHI-05 and WHI-07).
The Journal of antimicrobial chemotherapy 2002;50(6):793-803.
2002: Osmond J D'Cruz; fatih uckun
Metvan: a novel oxovanadium(IV) complex with broad spectrum anticancer activity.
Expert opinion on investigational drugs 2002;11(12):1829-36.
2002: Osmond J D'Cruz; Taracad K Venkatachalam; Chen Mao; Sanjive Qazi; fatih uckun
Structural requirements for potent anti-human immunodeficiency virus (HIV) and sperm-immobilizing activities of cyclohexenyl thiourea and urea non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Biology of reproduction 2002;67(6):1959-74.
2002: Chun-Lin Chen; Gengli Yu; Taracad K Venkatachalam; fatih uckun
Metabolism of stavudine-5'-[p-bromophenyl methoxyalaninyl phosphate], stampidine, in mice, dogs, and cats.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(12):1523-31.
2002: De-Min Zhu; Heather E Tibbles; Alexei O Vassilev; fatih uckun
SYK and LYN mediate B-cell receptor-independent calcium-induced apoptosis in DT-40 lymphoma B-cells.
Leukemia & lymphoma 2002;43(11):2165-70.
2002: Osmond J D'Cruz; Barbara Waurzyniak; fatih uckun
A 13-week subchronic intravaginal toxicity study of the novel broad-spectrum anti-HIV and spermicidal agent, N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea (PHI-346) in mice.
Toxicologic pathology 2002;30(6):687-95.
2002: fatih uckun; Sharon Pendergrass; Taracad K Venkatachalam; Sanjive Qazi; Douglas Richman
Stampidine is a potent inhibitor of Zidovudine- and nucleoside analog reverse transcriptase inhibitor-resistant primary clinical human immunodeficiency virus type 1 isolates with thymidine analog mutations.
Antimicrobial agents and chemotherapy 2002;46(11):3613-6.
2002: fatih uckun; Sanjive Qazi; Sharon Pendergrass; Elizabeth Lisowski; Barbara Waurzyniak; Chun-Lin Chen; Taracad K Venkatachalam
In vivo toxicity, pharmacokinetics, and anti-human immunodeficiency virus activity of stavudine-5'-(p-bromophenyl methoxyalaninyl phosphate) (stampidine) in mice.
Antimicrobial agents and chemotherapy 2002;46(11):3428-36.
2002: Osmond J D'Cruz; Douglas Erbeck; Barbara Waurzyniak; fatih uckun
Two-year toxicity and carcinogenicity studies in B(6)C(3)F(1) mice with 5-bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate (WHI-07), a novel anti-HIV and contraceptive agent.
Toxicology 2002;179(1-2):61-77.
2002: Taracad K Venkatachalam; Peter Samuel; I V Kourinov; fatih uckun
Synthesis and anti-HIV activity of carbamates of antiviral agent stavudine.
Antiviral chemistry & chemotherapy 2002;13(5):289-97.
2002: Patricia A Goodman; Brian Jurana; Carla M Wood; fatih uckun
Genomic studies of the spleen protein tyrosine kinase locus reveal a complex promoter structure and several genetic variants.
Leukemia & lymphoma 2002;43(8):1627-35.
2002: Alexei O Vassilev; David R Lorenz; Heather E Tibbles; fatih uckun
Role of the leukemia-associated transcription factor STAT3 in platelet physiology.
Leukemia & lymphoma 2002;43(7):1461-7.
2002: Marina Cetkovic-Cvrlje; Bertram A Roers; Dawn Schonhoff; Barbara Waurzyniak; Xing-Ping Liu; fatih uckun
Treatment of post-bone marrow transplant acute graft-versus-host disease with a rationally designed JAK3 inhibitor.
Leukemia & lymphoma 2002;43(7):1447-53.
2002: Ravi Malaviya; Christopher S Navara; fatih uckun
Augmentation of mast cell bactericidal activity by the anti-leukemic drug, 4-(3'bromo-4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline.
Leukemia & lymphoma 2002;43(6):1329-32.
2002: fatih uckun; Bertram A Roers; Barbara Waurzyniak; Xing-Ping Liu; Marina Cetkovic-Cvrlje
Janus kinase 3 inhibitor WHI-P131/JANEX-1 prevents graft-versus-host disease but spares the graft-versus-leukemia function of the bone marrow allografts in a murine bone marrow transplantation model.
Blood 2002;99(11):4192-9.
2002: fatih uckun; Peter Samuel; Sanjive Qazi; C Chen; Sharon Pendergrass; Taracad K Venkatachalam
Effects of aryl substituents on the anti-HIV activity of the arylphosphoramidate derivatives of stavudine.
Antiviral chemistry & chemotherapy 2002;13(3):197-203.
2002: Heather E Tibbles; Alexei O Vassilev; fatih uckun
A dual function anti-leukemic agent with anti-thrombotic activity.
Leukemia & lymphoma 2002;43(5):1121-7.
2002: fatih uckun; Yaguo Zheng; Marina Cetkovic-Cvrlje; Alexei O Vassilev; Elizabeth Lisowski; Barbara Waurzyniak; Hao Chen; Randy Carpenter; Chun-Lin Chen
In vivo pharmacokinetic features, toxicity profile, and chemosensitizing activity of alpha-cyano-beta-hydroxy-beta- methyl-N-(2,5-dibromophenyl)propenamide (LFM-A13), a novel antileukemic agent targeting Bruton's tyrosine kinase.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(5):1224-33.
2002: Heather E Tibbles; Christopher S Navara; Michael A Hupke; Alexei O Vassilev; fatih uckun
Thrombopoietin induces p-selectin expression on platelets and subsequent platelet/leukocyte interactions.
Biochemical and biophysical research communications 2002;292(4):987-91.
2002: Lei Sun; Hoshnuwar Kerawalla; Xian Wu; Matthew S Lehnert; fatih uckun
Expression of a unique helios isoform in human leukemia cells.
Leukemia & lymphoma 2002;43(4):841-9.
2002: Nyla A Heerema; Harland Sather; Martha G Sensel; Mei K La; Raymond J Hutchinson; James B Nachman; Gregory H Reaman; Beverly J Lange; Peter G Steinherz; Bruce C Bostrom; Paul S Gaynon; fatih uckun
Abnormalities of chromosome bands 15q13-15 in childhood acute lymphoblastic leukemia.
Cancer 2002;94(4):1102-10.
2002: Osmond J D'Cruz; Barbara Waurzyniak; fatih uckun
Subchronic (13-week) toxicity studies of intravaginal administration of spermicidal vanadocene acetylacetonato monotriflate in mice.
Toxicology 2002;170(1-2):31-43.
2002: fatih uckun; Xing Ping Liu; Osmond J D'Cruz
Human sperm immobilizing activity of aminophenyl arsenic acid and its N-substituted quinazoline, pyrimidine, and purine derivatives: protective effect of glutathione.
Reproductive toxicology (Elmsford, N.Y.) 2002;16(1):57-64.
2002: Ann T Kotchevar; David Perrey; fatih uckun
A degradation study of a series of chloromethyl and diazomethyl ketone anti-leukemic agents.
Drug development and industrial pharmacy 2002;28(2):143-9.
2002: Ravi Malaviya; fatih uckun
Role of STAT6 in IgE receptor/FcepsilonRI-mediated late phase allergic responses of mast cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):421-6.
2002: fatih uckun; Jason Thoen; Hao Chen; Elise Sudbeck; Chen Mao; Ravi Malaviya; Xing-Ping Liu; Chun-Lin Chen
CYP1A-mediated metabolism of the Janus kinase-3 inhibitor 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline: structural basis for inactivation by regioselective O-demethylation.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(1):74-85.
2001: C L Chen; K K Thoen; fatih uckun
High-performance liquid chromatographic methods for the determination of topoisomerase II inhibitors.
Journal of chromatography. B, Biomedical sciences and applications 2001;764(1-2):81-119.
2001: C Mao; M Zhou; fatih uckun
Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia.
The Journal of biological chemistry 2001;276(44):41435-43.
2001: Ravi Malaviya; A Vassilev; fatih uckun
2,4,6-Trihydroxy-alpha-p-methoxyphenylacetophenone (Compound D-58) is a potent inhibitor of allergic reactions.
American journal of therapeutics 2001;8(6):417-24.
2001: fatih uckun
Rationally designed anti-mitotic agents with pro-apoptotic activity.
Current pharmaceutical design 2001;7(16):1627-39.
2001: Osmond J D'Cruz; fatih uckun
Effect of pretreatment of semen with pokeweed antiviral protein on pregnancy outcome in the rabbit model.
Fertility and sterility 2001;76(4):830-3.
2001: Osmond J D'Cruz; Barbara Waurzyniak; fatih uckun
Subchronic (13-week) toxicity studies of intravaginal administration of spermicidal vanadocene dithiocarbamate in mice.
Contraception 2001;64(3):177-85.
2001: R Malaviya; fatih uckun
Leflunomide metabolite analogue alpha-cyano-beta-hydroxy-beta-methyl-N-[3-(trifluoromethyl)phenyl]propenamide inhibits IgE/FcepsilonRI receptor-mediated mast cell leukotriene release and allergic asthma in mice.
American journal of therapeutics 2001;8(5):309-16.
2001: Marina Cetkovic-Cvrlje; Bertram A Roers; Barbara Waurzyniak; Xing-Ping Liu; fatih uckun
Targeting Janus kinase 3 to attenuate the severity of acute graft-versus-host disease across the major histocompatibility barrier in mice.
Blood 2001;98(5):1607-13.
2001: fatih uckun; C Mao; ST Jan; H Huang; Alexei O Vassilev; Christopher S Navara; Rama Krishna Narla
Spongistatins as tubulin targeting agents.
Current pharmaceutical design 2001;7(13):1291-6.
2001: S Mahajan; Alexei O Vassilev; N Sun; ZAHIDE OZER; C Mao; fatih uckun
Transcription factor STAT5A is a substrate of Bruton's tyrosine kinase in B cells.
The Journal of biological chemistry 2001;276(33):31216-28.
2001: Francis Rajamohan; ZAHIDE OZER; Chen Mao; fatih uckun
Active center cleft residues of pokeweed antiviral protein mediate its high-affinity binding to the ribosomal protein L3.
Biochemistry 2001;40(31):9104-14.
2001: S Ghosh; X P Liu; Y Zheng; fatih uckun
Rational design of potent and selective EGFR tyrosine kinase inhibitors as anticancer agents.
Current cancer drug targets 2001;1(2):129-40.
2001: Osmond J D'Cruz; fatih uckun
Gel-microemulsions as vaginal spermicides and intravaginal drug delivery vehicles.
Contraception 2001;64(2):113-23.
2001: Ravi Malaviya; Christopher S Navara; fatih uckun
Role of Janus kinase 3 in mast cell-mediated innate immunity against gram-negative bacteria.
Immunity 2001;15(2):313-21.
2001: Osmond J D'Cruz; A O Vassilev; fatih uckun
Members of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway are present and active in human sperm.
Fertility and sterility 2001;76(2):258-66.
2001: Patricia A Goodman; Carla M Wood; Alexei O Vassilev; C Mao; fatih uckun
Spleen tyrosine kinase (Syk) deficiency in childhood pro-B cell acute lymphoblastic leukemia.
Oncogene 2001;20(30):3969-78.
2001: Taracad K Venkatachalam; Chen Mao; fatih uckun
Stereochemistry as a major determinant of the anti-HIV activity of chiral naphthyl thiourea compounds.
Antiviral chemistry & chemotherapy 2001;12(4):213-21.
2001: C L Chen; J Rawwas; A Sorrell; L Eddy; fatih uckun
Bioavailability and pharmacokinetic features of etoposide in childhood acute lymphoblastic leukemia patients.
Leukemia & lymphoma 2001;42(3):317-27.
2001: Osmond J D'Cruz; fatih uckun
Bis(4,7-dimethyl and 5-dinitro-1,10-phenanthroline) sulfato-oxovanadium(IV)-mediated in vivo male germ cell apoptosis.
Journal of applied toxicology : JAT 2001;21(4):331-9.
2001: Osmond J D'Cruz; fatih uckun
Lack of adverse effects on fertility of female CD-1 mice exposed to repetitive intravaginal gel-microemulsion formulation of a dual-function anti-HIV agent: aryl phosphate derivative of bromo-methoxy-zidovudine (compound WHI-07).
Journal of applied toxicology : JAT 2001;21(4):317-22.
2001: R K Narla; C L Chen; Y Dong; fatih uckun
In vivo antitumor activity of bis(4,7-dimethyl-1,10-phenanthroline) sulfatooxovanadium(IV) (METVAN [VO(SO4)(Me2-Phen)2]).
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(7):2124-33.
2001: Chun-Lin Chen; Taracad K Venkatachalam; Z H Zhu; fatih uckun
In vivo pharmacokinetics and metabolism of anti-human immunodeficiency virus agent D4T-5'-[p-bromophenyl methoxyalaninyl phosphate] (SAMPIDINE) in mice.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(7):1035-41.
2001: Francis Rajamohan; Chen Mao; fatih uckun
Binding interactions between the active center cleft of recombinant pokeweed antiviral protein and the alpha-sarcin/ricin stem loop of ribosomal RNA.
The Journal of biological chemistry 2001;276(26):24075-81.
2001: fatih uckun; N Pallisgaard; Peter Hokland; Christopher S Navara; Rama Krishna Narla; Paul S Gaynon; Harland Sather; Nyla A Heerema
Expression of TEL-AML1 fusion transcripts and response to induction therapy in standard risk acute lymphoblastic leukemia.
Leukemia & lymphoma 2001;42(1-2):41-56.
2001: Heather E Tibbles; Alexei O Vassilev; H Wendorf; D Schonhoff; D Zhu; D Lorenz; Barbara Waurzyniak; Xing-Ping Liu; fatih uckun
Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation.
The Journal of biological chemistry 2001;276(21):17815-22.
2001: Martin Reichel; E Gillert; Sabine Angermüller; J P Hensel; F Heidel; M Lode; Thomas Leis; Andrea Biondi; Oskar A Haas; Sabine Strehl; E Renate Panzer-Grümayer; F Griesinger; Jörn D Beck; Johann Greil; Georg H Fey; fatih uckun; Rolf Marschalek
Biased distribution of chromosomal breakpoints involving the MLL gene in infants versus children and adults with t(4;11) ALL.
Oncogene 2001;20(23):2900-7.
2001: fatih uckun; C J Forsyth
Anticancer activity of synthetic analogues of the phorboxazoles.
Bioorganic & medicinal chemistry letters 2001;11(9):1181-3.
2001: fatih uckun; EA Sudbeck; C Mao; S Ghosh; Xing-Ping Liu; Alexei O Vassilev; Christopher S Navara; Rama Krishna Narla
Structure-based design of novel anticancer agents.
Current cancer drug targets 2001;1(1):59-71.
2001: R K Narla; Y Dong; fatih uckun
Apoptosis inducing novel anti-leukemic agent, bis(4,7-dimethyl-1,10 phenanthroline) sulfatooxovanadium(IV) [VO(SO4)(Me2-Phen)2] depolarizes mitochondrial membranes.
Leukemia & lymphoma 2001;41(5-6):625-34.
2001: R Krishna Narla; Christopher S Navara; MB Sarquis; fatih uckun
Chemosensitivity of TEL-AML1 fusion transcript positive acute lymphoblastic leukemia cells.
Leukemia & lymphoma 2001;41(5-6):615-23.
2001: P Ghosh; S Ghosh; Christopher S Navara; Rama Krishna Narla; Alexey Benyumov; fatih uckun
X-ray structure, solution properties, and biological activity profile of vanadocene(IV) acetylacetonate complex,.
Journal of inorganic biochemistry 2001;84(3-4):241-53.
2001: Christopher S Navara; Alexey Benyumov; Alexei O Vassilev; Rama Krishna Narla; P Ghosh; fatih uckun
Vanadocenes as potent anti-proliferative agents disrupting mitotic spindle formation in cancer cells.
Anti-cancer drugs 2001;12(4):369-76.
2001: R K Narla; Y Dong; D Klis; fatih uckun
Bis(4,7-dimethyl-1,10-phenanthroline) sulfatooxovanadium(I.V.) as a novel antileukemic agent with matrix metalloproteinase inhibitory activity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(4):1094-101.
2001: Osmond J D'Cruz; fatih uckun
Short-Term (13-week) toxicity study of 5-bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate (WHI-07), a novel anti-HIV and contraceptive agent, in B6C3F1 mice.
Toxicological sciences : an official journal of the Society of Toxicology 2001;60(2):373-8.
2001: Taracad K Venkatachalam; EA Sudbeck; Chen Mao; fatih uckun
Anti-HIV activity of aromatic and heterocyclic thiazolyl thiourea compounds.
Bioorganic & medicinal chemistry letters 2001;11(4):523-8.
2001: A T Kotchevar; P Ghosh; D D DuMez; fatih uckun
Induction of aerobic peroxidation of liposomal membranes by bis(cyclopentadienyl)-vanadium(IV) (acetylacetonate) complexes.
Journal of inorganic biochemistry 2001;83(2-3):151-60.
2001: Osmond J D'Cruz; fatih uckun
Intravaginal toxicity studies of a gel-microemulsion formulation of spermicidal vanadocenes in rabbits.
Toxicology and applied pharmacology 2001;170(2):104-12.
2001: Osmond J D'Cruz; SH Yiv; fatih uckun
GM-144, a novel lipophilic vaginal contraceptive gel-microemulsion.
AAPS PharmSciTech 2001;2(2):E5.
2001: C L Chen; Taracad K Venkatachalam; Barbara Waurzyniak; LM Chelstrom; fatih uckun
In vivo toxicity, pharmacokinetic features and tissue distribution of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236), a potent non-nucleoside inhibitor of HIV-1 reverse transcriptase.
Arzneimittel-Forschung 2001;51(7):574-81.
2001: fatih uckun; Paul S Gaynon; D O Stram; Martha G Sensel; MB Sarquis; ML Willoughby
Bone marrow leukemic progenitor cell content in pediatric T-lineage acute lymphoblastic leukemia patients with an isolated extramedullary first relapse.
Leukemia & lymphoma 2001;40(3-4):279-85.
2001: R Malavija; C L Chen; X P Liu; fatih uckun
In vivo pharmacokinetics and anti-anaphylactic activity of the novel mast cell inhibitor 4-(4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131).
American journal of therapeutics 2001;8(1):35-9.
2001: E A Sudbeck; S Ghosh; X P Liu; Y Zheng; D E Myers; fatih uckun
Tyrosine kinase inhibitors against EGF receptor-positive malignancies.
Methods in molecular biology (Clifton, N.J.) 2001;166():193-218.
2001: S Ghosh ; J D Jennissen ; X P Liu ; fatih uckun
4-[3-Bromo-4-hydroxyphenyl)amino]-6,7-dimethoxyquinazolin-1-ium chloride methanol solvate and 4-[(3-hydroxyphenyl)amino]-6,7-dimethoxy-1-quinazolinium chloride.
Acta crystallographica. Section C, Crystal structure communications 2001;57(Pt 1):76-8.
2001: Osmond J D'Cruz; SH Yiv; Barbara Waurzyniak; fatih uckun
Contraceptive efficacy and safety studies of a novel microemulsion-based lipophilic vaginal spermicide.
Fertility and sterility 2001;75(1):115-24.
2001: Osmond J D'Cruz; fatih uckun
Pokeweed antiviral protein: a potential nonspermicidal prophylactic antiviral agent.
Fertility and sterility 2001;75(1):106-14.
2001: OJ D'Cruz; TK Venkatachalam; fatih uckun
Thymidine kinase-independent intracellular delivery of bioactive nucleotides by aryl phosphate derivatives of bromo-methoxy zidovudine (compounds WHI-05 and WHI-07) in normal human female genital tract epithelial cells and sperm.
Biology of reproduction 2001;64(1):51-9.
2000: I Dibirdik; M Bofenkamp; P Skeben; fatih uckun
Stimulation of Bruton's tyrosine kinase (BTK) and inositol 1,4,5-trisphosphate production in leukemia and lymphoma cells exposed to low energy electromagnetic fields.
Leukemia & lymphoma 2000;40(1-2):149-56.
2000: Ravi Malaviya; C L Chen; Christopher S Navara; R Malaviya; XP Liu; M Keenan; B Waurzyniak; fatih uckun
Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3', 5'-dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97).
The Journal of pharmacology and experimental therapeutics 2000;295(3):912-26.
2000: N A Heerema; Harland Sather; Martha G Sensel; M K Lee; Raymond J Hutchinson; James B Nachman; Gregory H Reaman; Beverly J Lange; Peter G Steinherz; Bruce C Bostrom; Paul S Gaynon; fatih uckun
Abnormalities of chromosome bands 13q12 to 13q14 in childhood acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(22):3837-44.
2000: Osmond J D'Cruz; Y Dong; fatih uckun
Apoptosis-inducing oxovanadium(IV) complexes of 1,10-phenanthroline against human ovarian cancer.
Anti-cancer drugs 2000;11(10):849-58.
2000: Chen Mao; EA Sudbeck; Taracad K Venkatachalam; fatih uckun
Structure-based drug design of non-nucleoside inhibitors for wild-type and drug-resistant HIV reverse transcriptase.
Biochemical pharmacology 2000;60(9):1251-65.
2000: D M Zhu; fatih uckun
Cathepsin inhibition induces apoptotic death in human leukemia and lymphoma cells.
Leukemia & lymphoma 2000;39(3-4):343-54.
2000: fatih uckun; C Mao; ST Jan; H Huang; Alexei O Vassilev; EA Sudbeck; Christopher S Navara; Rama Krishna Narla
SPIKET and COBRA compounds as novel tubulin modulators with potent anticancer activity.
Current opinion in investigational drugs (London, England : 2000) 2000;1(2):252-6.
2000: EA Sudbeck; J D Jennissen; Xing-Ping Liu; fatih uckun
An inhibitor of Janus kinase 3:4-(4-hydroxyphenylamino)-6, 7-dimethoxyquinazolin-1-ium chloride methanol solvate.
Acta crystallographica. Section C, Crystal structure communications 2000;56 ( Pt 10)():1282-3.
2000: S Ghosh; J D Jennissen; Y Zheng; fatih uckun
Three leflunomide metabolite analogs.
Acta crystallographica. Section C, Crystal structure communications 2000;56 ( Pt 10)():1254-7.
2000: Taracad K Venkatachalam; EA Sudbeck; C Mao; fatih uckun
Stereochemistry of halopyridyl and thiazolyl thiourea compounds is a major determinant of their potency as nonnucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorganic & medicinal chemistry letters 2000;10(18):2071-4.
2000: Taracad K Venkatachalam; E A Sudbec; Chen Mao; fatih uckun
Piperidinylethyl, phenoxyethyl and fluoroethyl bromopyridyl thiourea compounds with potent anti-HIV activity.
Antiviral chemistry & chemotherapy 2000;11(5):329-36.
2000: I V Kurinov; C Mao; JD Irvin; fatih uckun
X-ray crystallographic analysis of pokeweed antiviral protein-II after reductive methylation of lysine residues.
Biochemical and biophysical research communications 2000;275(2):549-52.
2000: fatih uckun; Linda C Stork; Nita L Seibel; MB Sarquis; C Bedros; Harland Sather; Martha G Sensel; Gregory H Reaman; Paul S Gaynon
Residual bone marrow leukemic progenitor cell burden after induction chemotherapy in pediatric patients with acute lymphoblastic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(8):3123-30.
2000: L B Niehoff; fatih uckun
Role of PRKCM (PKCmu) in radiation-induced increase of JUN proto-oncogene mRNA levels in B-lineage lymphoid cells.
Radiation research 2000;154(2):145-50.
2000: Osmond J D'Cruz; fatih uckun
Vanadocene-mediated in vivo male germ cell apoptosis.
Toxicology and applied pharmacology 2000;166(3):186-95.
2000: C L Chen; fatih uckun
Highly sensitive liquid chromatography-electrospray mass spectrometry (LC-MS) method for the determination of etoposide levels in human serum and plasma.
Journal of chromatography. B, Biomedical sciences and applications 2000;744(1):91-8.
2000: Osmond J D'Cruz; Barbara Waurzyniak; SH Yiv; fatih uckun
Evaluation of subchronic (13-week) and reproductive toxicity potential of intravaginal gel-microemulsion formulation of a dual-function phenyl phosphate derivative of bromo-methoxy zidovudine (compound whi-07) in B(6)C(3)F(1) mice.
Journal of applied toxicology : JAT 2000;20(4):319-25.
2000: OJ D'Cruz; TK Venkatachalam; fatih uckun
Novel thiourea compounds as dual-function microbicides.
Biology of reproduction 2000;63(1):196-205.
2000: ST Jan; C Mao; Alexei O Vassilev; Christopher S Navara; fatih uckun
COBRA-1, a rationally-designed epoxy-THF containing compound with potent tubulin depolymerizing activity as a novel anticancer agent.
Bioorganic & medicinal chemistry letters 2000;10(11):1193-7.
2000: D M Zhu; fatih uckun
Calpain inhibitor II induces caspase-dependent apoptosis in human acute lymphoblastic leukemia and non-Hodgkin's lymphoma cells as well as some solid tumor cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(6):2456-63.
2000: fatih uckun; C Mao; Alexei O Vassilev; Christopher S Navara; Rama Krishna Narla; ST Jan
A rationally designed anticancer drug targeting a unique binding cavity of tubulin.
Bioorganic & medicinal chemistry letters 2000;10(10):1015-8.
2000: De-Min Zhu; fatih uckun
Z-Phe-Gly-NHO-Bz, an inhibitor of cysteine cathepsins, induces apoptosis in human cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(5):2064-9.
2000: N A Heerema; Harland Sather; Martha G Sensel; T Zhang; Raymond J Hutchinson; James B Nachman; Beverly J Lange; Peter G Steinherz; Bruce C Bostrom; Gregory H Reaman; Paul S Gaynon; fatih uckun
Prognostic impact of trisomies of chromosomes 10, 17, and 5 among children with acute lymphoblastic leukemia and high hyperdiploidy (> 50 chromosomes).
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(9):1876-87.
2000: Osmond J D'Cruz; A Vassilev; fatih uckun
Evaluation of boar sperm as a model system to study the mechanism of spermicidal activity of vanadocenes.
Biochemical and biophysical research communications 2000;270(3):826-30.
2000: Nyla A Heerema; Harland Sather; Martha G Sensel; MK Lee; Raymond J Hutchinson; James B Nachman; Beverly J Lange; Peter G Steinherz; Bruce C Bostrom; Paul S Gaynon; fatih uckun
Prognostic significance of cytogenetic abnormalities of chromosome arm 12p in childhood acute lymphoblastic leukemia: a report from the Children's Cancer Group.
Cancer 2000;88(8):1945-54.
2000: Rama Krishna Narla; Y Dong; Osmond J D'Cruz; Christopher S Navara; fatih uckun
Bis(4,7-dimethyl-1,10-phenanthroline) sulfatooxovanadium(IV) as a novel apoptosis-inducing anticancer agent.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(4):1546-56.
2000: P Ghosh; Osmond J D'Cruz; Rama Krishna Narla; fatih uckun
Apoptosis-inducing vanadocene compounds against human testicular cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(4):1536-45.
2000: V N Trieu; Rama Krishna Narla; DE Myers; fatih uckun
EGF-genistein inhibits neointimal hyperplasia after vascular injury in an experimental restenosis model.
Journal of cardiovascular pharmacology 2000;35(4):595-605.
2000: OJ D'Cruz; A Vassilev; fatih uckun
Studies in humans on the mechanism of potent spermicidal and apoptosis-inducing activities of vanadocene complexes.
Biology of reproduction 2000;62(4):939-49.
2000: David Perrey; M P Scannell; Rama Krishna Narla; fatih uckun
The S-alkyl chain length as a determinant of the anti-leukemic activity of cysteine chloromethyl ketone compounds.
Bioorganic & medicinal chemistry letters 2000;10(6):551-2.
2000: David Perrey; Rama Krishna Narla; fatih uckun
Cysteine chloromethyl and diazomethyl ketone derivatives with potent anti-leukemic activity.
Bioorganic & medicinal chemistry letters 2000;10(6):547-9.
2000: fatih uckun; C Mao; Alexei O Vassilev; H Huang; ST Jan
Structure-based design of a novel synthetic spiroketal pyran as a pharmacophore for the marine natural product spongistatin 1.
Bioorganic & medicinal chemistry letters 2000;10(6):541-5.
2000: Y Dong; R K Narla; EA Sudbeck; fatih uckun
Synthesis, X-ray structure, and anti-leukemic activity of oxovanadium(IV) complexes.
Journal of inorganic biochemistry 2000;78(4):321-30.
2000: fatih uckun; Chen Mao; Sharon Pendergrass; D Maher; D Zhu; L Tuel-Ahlgren; Taracad K Venkatachalam
N-[2-(4-methylphenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea as a potent inhibitor of NNRTI-resistant and multidrug-resistant human immunodeficiency virus type 1.
Antiviral chemistry & chemotherapy 2000;11(2):135-40.
2000: Francis Rajamohan; S O Doumbia; C R Engstrom; S L Pendergras; D L Maher; fatih uckun
Expression of biologically active recombinant pokeweed antiviral protein in methylotrophic yeast Pichia pastoris.
Protein expression and purification 2000;18(2):193-201.
2000: VN Trieu; fatih uckun
Apolipoprotein E and apolipoprotein D expression in a murine model of singlet oxygen-induced cerebral stroke.
Biochemical and biophysical research communications 2000;268(3):835-41.
2000: Francis Rajamohan; M J Pugmire; Igor V Kurinov; fatih uckun
Modeling and alanine scanning mutagenesis studies of recombinant pokeweed antiviral protein.
The Journal of biological chemistry 2000;275(5):3382-90.
2000: Nyla A Heerema; Harland Sather; Martha G Sensel; MK Lee; Raymond J Hutchinson; Beverly J Lange; Bruce C Bostrom; James B Nachman; Peter G Steinherz; Paul S Gaynon; fatih uckun
Clinical significance of deletions of chromosome arm 6q in childhood acute lymphoblastic leukemia: a report from the Children's Cancer Group.
Leukemia & lymphoma 2000;36(5-6):467-78.
2000: V N Trieu; X P Liu; C L Chen; fatih uckun
Treatment of atherosclerosis in apolipoprotein E-deficient mice with 4-(3-Bromobenzoyl)-6,7-dimethoxyquinazoline (WHI-P164), a potent inhibitor of triglyceride synthesis.
Journal of cardiovascular pharmacology 2000;35(2):179-88.
2000: V N Trieu; R Liu; X P Liu; fatih uckun
A specific inhibitor of janus kinase-3 increases survival in a transgenic mouse model of amyotrophic lateral sclerosis.
Biochemical and biophysical research communications 2000;267(1):22-5.
2000: Y Dong; Taracad K Venkatachalam; Rama Krishna Narla; V N Trieu; EA Sudbeck; fatih uckun
Antioxidant function of phenethyl-5-bromo-pyridyl thiourea compounds with potent anti-HIV activity.
Bioorganic & medicinal chemistry letters 2000;10(1):87-90.
2000: R Malaviya; R Malaviya; fatih uckun
Anti-inflammatory activity of 2,4, 6-trihydroxy-alpha-p-methoxyphenyl-acetophenone (compound D-58).
Dermatology (Basel, Switzerland) 2000;201(4):337-42.
2000: Osmond J D'Cruz; Barbara Waurzyniak; SH Yiv; fatih uckun
Evaluation of subchronic (13 weeks) and reproductive toxicity potential of intravaginal gel-microemulsion formulation of a dual-function phenyl phosphate derivative of bromo-methoxy zidovudine (compound WHI-05) in B(6)C(3)F(1) mice.
Contraception 2000;61(1):69-76.
2000: Taracad K Venkatachalam; O J D'Cruz; fatih uckun
Importance of the alanine methyl ester side chain for the biological activity profile of dual-function phenyl phosphate derivatives of bromo-methoxy-zidovudine.
Antiviral chemistry & chemotherapy 2000;11(1):31-9.
2000: Ravi Malaviya; fatih uckun
Histamine as an autocrine regulator of leukemic cell proliferation.
Leukemia & lymphoma 2000;36(3-4):367-73.
2000: OJ D'Cruz; TK Venkatachalam; fatih uckun
Structural requirements for potent human spermicidal activity of dual-function aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07).
Biology of reproduction 2000;62(1):37-44.
1999: fatih uckun; Sharon Pendergrass; D Maher; D Zhu; L Tuel-Ahlgren; Chen Mao; Taracad K Venkatachalam
N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea as a potent inhibitor of NNI-resistant and multidrug-resistant human immunodeficiency virus-1.
Bioorganic & medicinal chemistry letters 1999;9(24):3411-6.
1999: EA Sudbeck; J D Jennissen; Taracad K Venkatachalam; fatih uckun
Inhibitor of HIV-1 reverse transcriptase: N'-(5-bromo-2-pyridyl)-N-[2-(2,5-dimethoxyphenyl)ethyl]thiourea.
Acta crystallographica. Section C, Crystal structure communications 1999;55 ( Pt 12)():2122-4.
1999: Nyla A Heerema; James B Nachman; Harland Sather; Martha G Sensel; MK Lee; Raymond J Hutchinson; Beverly J Lange; Peter G Steinherz; Bruce C Bostrom; Paul S Gaynon; fatih uckun
Hypodiploidy with less than 45 chromosomes confers adverse risk in childhood acute lymphoblastic leukemia: a report from the children's cancer group.
Blood 1999;94(12):4036-45.
1999: S Ghosh; Y Zheng; X Jun; S Mahajan; C Mao; EA Sudbeck; fatih uckun
Specificity of alpha-cyano-beta-hydroxy-beta-methyl-n-[4-(trifluoromethoxy)phe nyl]-propenamide as an inhibitor of the epidermal growth factor receptor tyrosine kinase.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(12):4264-72.
1999: fatih uckun; Y Messinger; CL Chen; K O'Neill; DE Myers; F Goldman; C Hurvitz; J T Casper; A Levine
Treatment of therapy-refractory B-lineage acute lymphoblastic leukemia with an apoptosis-inducing CD19-directed tyrosine kinase inhibitor.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(12):3906-13.
1999: CL Chen; A Levine; A Rao; K O'Neill; Y Messinger; DE Myers; F Goldman; C Hurvitz; J T Casper; fatih uckun
Clinical pharmacokinetics of the CD19 receptor-directed tyrosine kinase inhibitor B43-Genistein in patients with B-lineage lymphoid malignancies.
Journal of clinical pharmacology 1999;39(12):1248-55.
1999: L Sun; Patricia A Goodman; C M Wood; ML Crotty; Martha G Sensel; Harland Sather; Christopher S Navara; James B Nachman; Peter G Steinherz; Paul S Gaynon; Nita L Seibel; Alexei O Vassilev; B D Juran; Gregory H Reaman; fatih uckun
Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(12):3753-66.
1999: fatih uckun; K Bellomy; K O'Neill; Y Messinger; T Johnson; CL Chen
Toxicity, biological activity, and pharmacokinetics of TXU (anti-CD7)-pokeweed antiviral protein in chimpanzees and adult patients infected with human immunodeficiency virus.
The Journal of pharmacology and experimental therapeutics 1999;291(3):1301-7.
1999: Igor V Kurinov; Francis Rajamohan; TK Venkatachalam; fatih uckun
X-ray crystallographic analysis of the structural basis for the interaction of pokeweed antiviral protein with guanine residues of ribosomal RNA.
Protein science : a publication of the Protein Society 1999;8(11):2399-405.
1999: V N Trieu; Y Dong; Y Zheng; fatih uckun
In vivo antioxidant activity of genistein in a murine model of singlet oxygen-induced cerebral stroke.
Radiation research 1999;152(5):508-16.
1999: EA Sudbeck; fatih uckun
Recent advances in JAK3 kinase inhibitors.
IDrugs : the investigational drugs journal 1999;2(10):1026-30.
1999: S Ghosh; Rama Krishna Narla; Y Zheng; X P Liu; X Jun; C Mao; EA Sudbeck; fatih uckun
Structure-based design of potent inhibitors of EGF-receptor tyrosine kinase as anti-cancer agents.
Anti-cancer drug design 1999;14(5):403-10.
1999: fatih uckun; O Ek; X P Liu; C L Chen
In vivo toxicity and pharmacokinetic features of the janus kinase 3 inhibitor WHI-P131 [4-(4'hydroxyphenyl)-amino-6,7- dimethoxyquinazoline.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(10):2954-62.
1999: Francis Rajamohan; Igor V Kurinov; TK Venkatachalam; fatih uckun
Deguanylation of human immunodeficiency virus (HIV-1) RNA by recombinant pokeweed antiviral protein.
Biochemical and biophysical research communications 1999;263(2):419-24.
1999: fatih uckun; Chen Mao; Sharon Pendergrass; D Maher; D Zhu; L Tuel-Ahlgren; Taracad K Venkatachalam
N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea and N'-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-chloropyridyl)]-thiourea as potent inhibitors of multidrug-resistant human immunodeficiency virus-1.
Bioorganic & medicinal chemistry letters 1999;9(18):2721-6.
1999: R Malaviya; D Zhu; I Dibirdik; fatih uckun
Targeting Janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxis.
The Journal of biological chemistry 1999;274(38):27028-38.
1999: fatih uckun; O J D'Cruz
Prophylactic contraceptives for HIV/AIDS.
Human reproduction update 1999;5(5):506-14.
1999: C Mao; EA Sudbeck; Taracad K Venkatachalam; fatih uckun
Structure-based design of non-nucleoside reverse transcriptase inhibitors of drug-resistant human immunodeficiency virus.
Antiviral chemistry & chemotherapy 1999;10(5):233-40.
1999: fatih uckun; Paul S Gaynon; D O Stram; Martha G Sensel; MB Sarquis; K H Lazarus; ML Willoughby
Paucity of leukemic progenitor cells in the bone marrow of pediatric B-lineage acute lymphoblastic leukemia patients with an isolated extramedullary first relapse.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(9):2415-20.
1999: I V Kurinov; DE Myers; JD Irvin; fatih uckun
X-ray crystallographic analysis of the structural basis for the interactions of pokeweed antiviral protein with its active site inhibitor and ribosomal RNA substrate analogs.
Protein science : a publication of the Protein Society 1999;8(9):1765-72.
1999: Nyla A Heerema; Harland Sather; Martha G Sensel; Wen Liu; Beverly J Lange; Bruce C Bostrom; James B Nachman; Peter G Steinherz; Raymond J Hutchinson; Paul S Gaynon; Diane C Arthur; fatih uckun
Association of chromosome arm 9p abnormalities with adverse risk in childhood acute lymphoblastic leukemia: A report from the Children's Cancer Group.
Blood 1999;94(5):1537-44.
1999: S Ghosh; fatih uckun
Alpha-cyano-N-(2,5-dibromophenyl)-beta-hydroxybut-2-enamide.
Acta crystallographica. Section C, Crystal structure communications 1999;55 ( Pt 8)():1364-5.
1999: Y Messinger; fatih uckun
A critical risk-benefit assessment argues against the use of anthracyclines in induction regimens for newly diagnosed childhood acute lymphoblastic leukemia.
Leukemia & lymphoma 1999;34(5-6):415-32.
1999: L Sun; ML Crotty; Martha G Sensel; Harland Sather; Christopher S Navara; James B Nachman; Peter G Steinherz; Paul S Gaynon; Nita L Seibel; C Mao; Alexei O Vassilev; Gregory H Reaman; fatih uckun
Expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(8):2112-20.
1999: CL Chen; fatih uckun
Evaluation of the pharmacokinetic features and tissue distribution of the potent nonnucleoside inhibitor of HIV-1 reverse transcriptase, N-[2-(2-fluorophenethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-240) with an analytical HPLC method.
Pharmaceutical research 1999;16(8):1226-32.
1999: Francis Rajamohan; TK Venkatachalam; J D Irvin; fatih uckun
Pokeweed antiviral protein isoforms PAP-I, PAP-II, and PAP-III depurinate RNA of human immunodeficiency virus (HIV)-1.
Biochemical and biophysical research communications 1999;260(2):453-8.
1999: CL Chen; H L Tai; D M Zhu; fatih uckun
Pharmacokinetic features and metabolism of calphostin C, a naturally occurring perylenequinone with antileukemic activity.
Pharmaceutical research 1999;16(7):1003-9.
1999: Francis Rajamohan; C R Engstrom; T J Denton; L A Engen; I Kourinov; fatih uckun
High-level expression and purification of biologically active recombinant pokeweed antiviral protein.
Protein expression and purification 1999;16(2):359-68.
1999: C Mao; ZAHIDE OZER; M Zhou; fatih uckun
X-Ray structure of glycerol kinase complexed with an ATP analog implies a novel mechanism for the ATP-dependent glycerol phosphorylation by glycerol kinase.
Biochemical and biophysical research communications 1999;259(3):640-4.
1999: P Ghosh; O J D'Cruz; D D DuMez; J Peitersen; fatih uckun
Structural and functional characterization of seven spermicidal vanadium(IV) complexes: potentiation of activity by methyl substitution on the cyclopentadienyl rings.
Journal of inorganic biochemistry 1999;75(2):135-43.
1999: C Mao; EA Sudbeck; Taracad K Venkatachalam; fatih uckun
Rational design of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236) as a potent non-nucleoside inhibitor of drug-resistant human immunodeficiency virus.
Bioorganic & medicinal chemistry letters 1999;9(11):1593-8.
1999: EA Sudbeck; Xing-Ping Liu; Rama Krishna Narla; S Mahajan; S Ghosh; C Mao; fatih uckun
Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(6):1569-82.
1999: Osmond J D'Cruz; fatih uckun
Novel derivatives of phenethyl-5-bromopyridylthiourea and dihydroalkoxybenzyloxopyrimidine are dual-function spermicides with potent anti-human immunodeficiency virus activity.
Biology of reproduction 1999;60(6):1419-28.
1999: VN Trieu; fatih uckun
Genistein is neuroprotective in murine models of familial amyotrophic lateral sclerosis and stroke.
Biochemical and biophysical research communications 1999;258(3):685-8.
1999: Osmond J D'Cruz; Z Zhu; SH Yiv; CL Chen; Barbara Waurzyniak; fatih uckun
WHI-05, a novel bromo-methoxy substituted phenyl phosphate derivative of zidovudine, is a dual-action spermicide with potent anti-HIV activity.
Contraception 1999;59(5):319-31.
1999: Osmond J D'Cruz; MJ Shih; SH Yiv; CL Chen; fatih uckun
Synthesis, characterization and preclinical formulation of a dual-action phenyl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07) with potent anti-HIV and spermicidal activities.
Molecular human reproduction 1999;5(5):421-32.
1999: C L Chen; Ravi Malaviya; H Chen; XP Liu; fatih uckun
Quantitative high-performance liquid chromatographic method for pharmacokinetic studies of the potent mast cell inhibitor 4-(4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P131).
Journal of chromatography. B, Biomedical sciences and applications 1999;727(1-2):205-12.
1999: R Malaviya; fatih uckun
Genetic and biochemical evidence for a critical role of Janus kinase (JAK)-3 in mast cell-mediated type I hypersensitivity reactions.
Biochemical and biophysical research communications 1999;257(3):807-13.
1999: VN Trieu; fatih uckun
Apolipoprotein(a), a link between atherosclerosis and tumor angiogenesis.
Biochemical and biophysical research communications 1999;257(3):714-8.
1999: S Mahajan; S Ghosh; EA Sudbeck; Y Zheng; S Downs; M Hupke; fatih uckun
Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [alpha-cyano-beta-hydroxy-beta-methyl-N-(2, 5-dibromophenyl)propenamide].
The Journal of biological chemistry 1999;274(14):9587-99.
1999: Y Messinger; Gregory H Reaman; O Ek; fatih uckun
Evaluation of temozolomide in a SCID mouse model of human B-cell precursor leukemia.
Leukemia & lymphoma 1999;33(3-4):289-93.
1999: C L Chen; H Chen; D M Zhu; fatih uckun
Quantitative high-performance liquid chromatography-based detection method for calphostin C, a naturally occurring perylenequinone with potent antileukemic activity.
Journal of chromatography. B, Biomedical sciences and applications 1999;724(1):157-62.
1999: fatih uckun; James B Nachman; Harland Sather; Martha G Sensel; P Kraft; Peter G Steinherz; B Lange; Raymond J Hutchinson; Gregory H Reaman; Paul S Gaynon; Nyla A Heerema
Poor treatment outcome of Philadelphia chromosome-positive pediatric acute lymphoblastic leukemia despite intensive chemotherapy.
Leukemia & lymphoma 1999;33(1-2):101-6.
1999: VN Trieu; fatih uckun
Low density lipoprotein (LDL)-mediated suppression of Lewis lung carcinoma in hypercholesterolemic LDL receptor-deficient mice.
Biochemical and biophysical research communications 1999;255(2):377-81.
1999: Gregory H Reaman; Richard Sposto; Martha G Sensel; Beverly J Lange; James Feusner; Nyla A Heerema; M Leonard; Emiko J Holmes; Harland Sather; T W Pendergrass; Helen S Johnstone; R T O'Brien; Peter G Steinherz; Paul M Zeltzer; Paul S Gaynon; Michael E Trigg; fatih uckun
Treatment outcome and prognostic factors for infants with acute lymphoblastic leukemia treated on two consecutive trials of the Children's Cancer Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(2):445-55.
1999: fatih uckun; Barbara Waurzyniak; Harland Sather; Martha G Sensel; LM Chelstrom; James B Nachman; Paul S Gaynon; Bruce C Bostrom; O Ek; MB Sarquis; Peter G Steinherz; Gregory H Reaman
Prognostic significance of T-lineage leukemic cell growth in SCID mice: a Children's Cancer Group study.
Leukemia & lymphoma 1999;32(5-6):475-87.
1999: De-Min Zhu; W H Fang; R K Narla; fatih uckun
A requirement for protein kinase C inhibition for calcium-triggered apoptosis in acute lymphoblastic leukemia cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(2):355-60.
1999: R Liu; R K Narla; I Kurinov; B Li; fatih uckun
Increased hydroxyl radical production and apoptosis in PC12 neuron cells expressing the gain-of-function mutant G93A SOD1 gene.
Radiation research 1999;151(2):133-41.
1999: Jiri Aubrecht; R K Narla; P Ghosh; J Stanek; fatih uckun
Molecular genotoxicity profiles of apoptosis-inducing vanadocene complexes.
Toxicology and applied pharmacology 1999;154(3):228-35.
1999: O J D'Cruz; Y Dong; fatih uckun
Spermicidal activity of oxovanadium(IV) complexes of 1, 10-phenanthroline, 2,2'-bipyridyl, 5'-bromo-2'-hydroxyacetophenone and derivatives in humans.
Biology of reproduction 1999;60(2):435-44.
1999: L Sun; N Heerema; L Crotty; X Wu; Christopher S Navara; Alexei O Vassilev; Martha G Sensel; Gregory H Reaman; fatih uckun
Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):680-5.
1999: Alexei O Vassilev; ZAHIDE OZER; Christopher S Navara; S Mahajan; fatih uckun
Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex.
The Journal of biological chemistry 1999;274(3):1646-56.
1999: D E Myers; fatih uckun
In vivo toxicity, pharmacokinetic features, and immunogenicity of B43(Anti-CD19)-genistein immunoconjugate in mice and non-human primates.
Journal of medicinal food 1999;2(3-4):173-5.
1999: ST Jan; Z Zhu; H L Tai; MJ Shih; Taracad K Venkatachalam; fatih uckun
AZT-5'-(p-bromophenyl methoxyalaninyl phosphate) as a potent and non-toxic anti-human immunodeficiency virus agent.
Antiviral chemistry & chemotherapy 1999;10(1):47-52.
1999: ST Jan; MJ Shih; Taracad K Venkatachalam; Osmond J D'Cruz; CL Chen; fatih uckun
Synthesis of dual function (5R,6R)- and (5S,6S)-5-bromo-6-methoxy-5,6-dihydro-AZT-5'-(para-bromophenyl methoxyalaninyl phosphate) as novel spermicidal and anti-HIV agents.
Antiviral chemistry & chemotherapy 1999;10(1):39-46.
1999: bruce witthuhn; M D Williams; H Kerawalla; fatih uckun
Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (IL2R) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery.
Leukemia & lymphoma 1999;32(3-4):289-97.
1999: CL Chen; Ravi Malaviya; Christopher S Navara; H Chen; B Bechard; G Mitcheltree; XP Liu; fatih uckun
Pharmacokinetics and biologic activity of the novel mast cell inhibitor, 4-(3-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline in mice.
Pharmaceutical research 1999;16(1):117-22.
1999: K G Waddick; fatih uckun
Innovative treatment programs against cancer: II. Nuclear factor-kappaB (NF-kappaB) as a molecular target.
Biochemical pharmacology 1999;57(1):9-17.
1998: Barbara Waurzyniak; Nyla A Heerema; Martha G Sensel; Paul S Gaynon; P Kraft; Harland Sather; LM Chelstrom; Gregory H Reaman; fatih uckun
Distinct in vivo engraftment and growth patterns of t(1;19)+/E2A-PBX1+ and t(9;22)+/BCR-ABL+ human leukemia cells in SCID mice.
Leukemia & lymphoma 1998;32(1-2):77-87.
1998: De-Min Zhu; R K Narla; W H Fang; N C Chia; fatih uckun
Calphostin C triggers calcium-dependent apoptosis in human acute lymphoblastic leukemia cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(12):2967-76.
1998: EA Sudbeck; Chen Mao; R Vig; Taracad K Venkatachalam; L Tuel-Ahlgren; fatih uckun
Structure-based design of novel dihydroalkoxybenzyloxopyrimidine derivatives as potent nonnucleoside inhibitors of the human immunodeficiency virus reverse transcriptase.
Antimicrobial agents and chemotherapy 1998;42(12):3225-33.
1998: K G Waddick; fatih uckun
Innovative treatment programs against cancer. I. Ras oncoprotein as a molecular target.
Biochemical pharmacology 1998;56(11):1411-26.
1998: Taracad K Venkatachalam; H L Tai; R Vig; C L Chen; ST Jan; fatih uckun
Enhancing effects of a mono-bromo substitution at the para position of the phenyl moiety on the metabolism and anti-HIV activity of d4T-phenyl methoxyalaninyl phosphate derivatives.
Bioorganic & medicinal chemistry letters 1998;8(22):3121-6.
1998: Quanzhi Li; Wendy A Hudson; D Wang; E Berven; fatih uckun; John H Kersey
Pharmacokinetics and biodistribution of radioimmunoconjugates of anti-CD19 antibody and single-chain Fv for treatment of human B-cell malignancy.
Cancer immunology, immunotherapy : CII 1998;47(3):121-30.
1998: S Ghosh; Y Zheng; X Jun; Rama Krishna Narla; S Mahajan; Christopher S Navara; C Mao; EA Sudbeck; fatih uckun
Alpha-cyano-beta-hydroxy-beta-methyl-N-[4-(trifluoromethoxy)phenyl] propenamide: an inhibitor of the epidermal growth factor receptor tyrosine kinase with potent cytotoxic activity against breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(11):2657-68.
1998: fatih uckun; James B Nachman; Harland Sather; Martha G Sensel; P Kraft; Peter G Steinherz; B Lange; Raymond J Hutchinson; Gregory H Reaman; Paul S Gaynon; Nyla A Heerema
Clinical significance of Philadelphia chromosome positive pediatric acute lymphoblastic leukemia in the context of contemporary intensive therapies: a report from the Children's Cancer Group.
Cancer 1998;83(9):2030-9.
1998: P Ghosh; S Ghosh; O J D'Cruz; fatih uckun
Structural and biological characterization of a novel spermicidal vanadium(IV) complex: bis(pi-cyclopentadienyl)-N,N-diethyl dithiocarbamato vanadium(IV) tetrafluoro borate, [VCp2(DeDtc)](BF4).
Journal of inorganic biochemistry 1998;72(1-2):89-98.
1998: R Vig; Chen Mao; Taracad K Venkatachalam; L Tuel-Ahlgren; EA Sudbeck; fatih uckun
Rational design and synthesis of phenethyl-5-bromopyridyl thiourea derivatives as potent non-nucleoside inhibitors of HIV reserve transcriptase.
Bioorganic & medicinal chemistry 1998;6(10):1789-97.
1998: Rama Krishna Narla; Xing-Ping Liu; D Klis; fatih uckun
Inhibition of human glioblastoma cell adhesion and invasion by 4-(4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131) and 4-(3'-bromo-4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P154).
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(10):2463-71.
1998: fatih uckun
Bruton's tyrosine kinase (BTK) as a dual-function regulator of apoptosis.
Biochemical pharmacology 1998;56(6):683-91.
1998: R Vig; Taracad K Venkatachalam; fatih uckun
D4T-5'-[p-bromophenyl methoxyalaninyl phosphate] as a potent and non-toxic anti-human immunodeficiency virus agent.
Antiviral chemistry & chemotherapy 1998;9(5):445-8.
1998: R Vig; Taracad K Venkatachalam; ST Jan; fatih uckun
Aryl phosphate derivatives of 3'-deoxythymidine are not potent anti-human immunodeficiency virus agents.
Antiviral chemistry & chemotherapy 1998;9(5):439-43.
1998: O Ek; Paul S Gaynon; T Zeren; LM Chelstrom; DE Myers; fatih uckun
Treatment of human B-cell precursor leukemia in SCID mice by using a combination of the anti-CD19 immunotoxin B43-PAP with the standard chemotherapeutic drugs vincristine, methylprednisolone, and L-asparaginase.
Leukemia & lymphoma 1998;31(1-2):143-9.
1998: Osmond J D'Cruz; Taracad K Venkatachalam; Z Zhu; MJ Shih; fatih uckun
Aryl phosphate derivatives of bromo-methoxy-azidothymidine are dual-function spermicides with potent anti-human immunodeficiency virus.
Biology of reproduction 1998;59(3):503-15.
1998: Chen Mao; R Vig; Taracad K Venkatachalam; EA Sudbeck; fatih uckun
Structure-based design of N-[2-(1-piperidinylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea and N-[2-(1-piperazinylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorganic & medicinal chemistry letters 1998;8(16):2213-8.
1998: fatih uckun; Harland Sather; Barbara Waurzyniak; Martha G Sensel; LM Chelstrom; O Ek; MB Sarquis; James B Nachman; Bruce C Bostrom; Gregory H Reaman; Paul S Gaynon
Prognostic significance of B-lineage leukemic cell growth in SCID mice: a Children's Cancer Group Study.
Leukemia & lymphoma 1998;30(5-6):503-14.
1998: fatih uckun; K Herman-Hatten; ML Crotty; Martha G Sensel; Harland Sather; L Tuel-Ahlgren; MB Sarquis; Bruce C Bostrom; James B Nachman; Peter G Steinherz; Paul S Gaynon; Nyla A Heerema
Clinical significance of MLL-AF4 fusion transcript expression in the absence of a cytogenetically detectable t(4;11)(q21;q23) chromosomal translocation.
Blood 1998;92(3):810-21.
1998: P A Goodman; L B Niehoff; fatih uckun
Role of tyrosine kinases in induction of the c-jun proto-oncogene in irradiated B-lineage lymphoid cells.
The Journal of biological chemistry 1998;273(28):17742-8.
1998: O Ek; Y Yanishevski; T Zeren; Barbara Waurzyniak; R Gunther; LM Chelstrom; M Chandan-Langlie; E Schneider; DE Myers; W Evans; fatih uckun
In vivo toxicity and pharmacokinetic features of B43(Anti-CD19)-Genistein immunoconjugate.
Leukemia & lymphoma 1998;30(3-4):389-94.
1998: fatih uckun; Barbara Waurzyniak; Martha G Sensel; LM Chelstrom; ML Crotty; Paul S Gaynon; Gregory H Reaman
Primary blasts from infants with acute lymphoblastic leukemia cause overt leukemia in SCID mice.
Leukemia & lymphoma 1998;30(3-4):269-77.
1998: Osmond J D'Cruz; P Ghosh; fatih uckun
Spermicidal activity of chelated complexes of bis(cyclopentadienyl)vanadium(IV).
Molecular human reproduction 1998;4(7):683-93.
1998: O Ek; Barbara Waurzyniak; DE Myers; fatih uckun
Antitumor activity of TP3(anti-p80)-pokeweed antiviral protein immunotoxin in hamster cheek pouch and severe combined immunodeficient mouse xenograft models of human osteosarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(7):1641-7.
1998: M D Williams; A Rostovtsev; R K Narla; fatih uckun
Production of recombinant DTctGMCSF fusion toxin in a baculovirus expression vector system for biotherapy of GMCSF-receptor positive hematologic malignancies.
Protein expression and purification 1998;13(2):210-21.
1998: V N Trieu; fatih uckun
Male-associated hypertension in LDL-R deficient mice.
Biochemical and biophysical research communications 1998;247(2):277-9.
1998: R Vig; Chen Mao; Taracad K Venkatachalam; L Tuel-Ahlgren; EA Sudbeck; fatih uckun
5-Alkyl-2-[(methylthiomethyl)thio]-6-(benzyl)-pyrimidin-4-(1H)-ones as potent non-nucleoside reverse transcriptase inhibitors of S-DABO series.
Bioorganic & medicinal chemistry letters 1998;8(12):1461-6.
1998: James B Nachman; Harland Sather; Martha G Sensel; Michael E Trigg; Joel M Cherlow; John Lukens; L Wolff; fatih uckun; Paul S Gaynon
Augmented post-induction therapy for children with high-risk acute lymphoblastic leukemia and a slow response to initial therapy.
The New England journal of medicine 1998;338(23):1663-71.
1998: Rama Krishna Narla; Xing-Ping Liu; DE Myers; fatih uckun
4-(3'-Bromo-4'hydroxylphenyl)-amino-6,7-dimethoxyquinazoline: a novel quinazoline derivative with potent cytotoxic activity against human glioblastoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(6):1405-14.
1998: O J D'Cruz; P Ghosh; fatih uckun
Spermicidal activity of metallocene complexes containing vanadium(IV) in humans.
Biology of reproduction 1998;58(6):1515-26.
1998: D Kristupaitis; Ilker Dibirdik; Alexei O Vassilev; S Mahajan; T Kurosaki; A Chu; L Tuel-Ahlgren; D Tuong; D Pond; R Luben; fatih uckun
Electromagnetic field-induced stimulation of Bruton's tyrosine kinase.
The Journal of biological chemistry 1998;273(20):12397-401.
1998: fatih uckun; Rama Krishna Narla; T Zeren; Y Yanishevski; DE Myers; Barbara Waurzyniak; O Ek; E Schneider; Y Messinger; LM Chelstrom; R Gunther; W Evans
In vivo toxicity, pharmacokinetics, and anticancer activity of Genistein linked to recombinant human epidermal growth factor.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(5):1125-34.
1998: DE Myers; A Sicheneder; D Clementson; N Dvorak; Taracad K Venkatachalam; A R Sev; M Chandan-Langlie; fatih uckun
Large scale manufacturing of B43(anti-CD19)-genistein for clinical trials in leukemia and lymphoma.
Leukemia & lymphoma 1998;29(3-4):329-38.
1998: fatih uckun; Rama Krishna Narla; X Jun; T Zeren; Taracad K Venkatachalam; K G Waddick; A Rostostev; DE Myers
Cytotoxic activity of epidermal growth factor-genistein against breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(4):901-12.
1998: Nyla A Heerema; Harland Sather; Martha G Sensel; P Kraft; James B Nachman; Peter G Steinherz; Beverly J Lange; Raymond J Hutchinson; Gregory H Reaman; Michael E Trigg; Diane C Arthur; Paul S Gaynon; fatih uckun
Frequency and clinical significance of cytogenetic abnormalities in pediatric T-lineage acute lymphoblastic leukemia: a report from the Children's Cancer Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(4):1270-8.
1998: Ilker Dibirdik; D Kristupaitis; T Kurosaki; L Tuel-Ahlgren; A Chu; D Pond; D Tuong; R Luben; fatih uckun
Stimulation of Src family protein-tyrosine kinases as a proximal and mandatory step for SYK kinase-dependent phospholipase Cgamma2 activation in lymphoma B cells exposed to low energy electromagnetic fields.
The Journal of biological chemistry 1998;273(7):4035-9.
1998: O Ek; Gregory H Reaman; D L Crankshaw; LM Chelstrom; DE Myers; fatih uckun
Combined therapeutic efficacy of the thymidylate synthase inhibitor ZD1694 (Tomudex) and the immunotoxin B43(anti-CD19)-PAP in a SCID mouse model of human B-lineage acute lymphoblastic leukemia.
Leukemia & lymphoma 1998;28(5-6):509-14.
1998: fatih uckun; LM Chelstrom; L Tuel-Ahlgren; Ilker Dibirdik; JD Irvin; MC Langlie; DE Myers
TXU (anti-CD7)-pokeweed antiviral protein as a potent inhibitor of human immunodeficiency virus.
Antimicrobial agents and chemotherapy 1998;42(2):383-8.
1998: fatih uckun; Martha G Sensel; Harland Sather; Paul S Gaynon; Diane C Arthur; Beverly J Lange; Peter G Steinherz; P Kraft; Raymond J Hutchinson; James B Nachman; Gregory H Reaman; Nyla A Heerema
Clinical significance of translocation t(1;19) in childhood acute lymphoblastic leukemia in the context of contemporary therapies: a report from the Children's Cancer Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(2):527-35.
1998: Peter G Steinherz; Paul S Gaynon; John C. Breneman; Joel M Cherlow; N J Grossman; John H Kersey; Helen S Johnstone; Harland Sather; Michael E Trigg; fatih uckun; Archie Bleyer
Treatment of patients with acute lymphoblastic leukemia with bulky extramedullary disease and T-cell phenotype or other poor prognostic features: randomized controlled trial from the Children's Cancer Group.
Cancer 1998;82(3):600-12.
1998: fatih uckun; Martha G Sensel; L Sun; Peter G Steinherz; Michael E Trigg; Nyla A Heerema; Harland Sather; Gregory H Reaman; Paul S Gaynon
Biology and treatment of childhood T-lineage acute lymphoblastic leukemia.
Blood 1998;91(3):735-46.
1998: Y Messinger; Y Yanishevski; O Ek; T Zeren; Barbara Waurzyniak; R Gunther; LM Chelstrom; M Chandan-Langlie; E Schneider; DE Myers; W Evans; fatih uckun
In vivo toxicity and pharmacokinetic features of B43 (anti-CD19)-genistein immunoconjugate in nonhuman primates.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(1):165-70.
1997: J P Perentesis; R Gunther; Barbara Waurzyniak; Y Yanishevski; DE Myers; O Ek; Y Messinger; Y Shao; LM Chelstrom; E Schneider; William Evans; fatih uckun
In vivo biotherapy of HL-60 myeloid leukemia with a genetically engineered recombinant fusion toxin directed against the human granulocyte macrophage colony-stimulating factor receptor.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(12 Pt 1):2217-27.
1997: fatih uckun; Harland Sather; Paul S Gaynon; D Arthur; James B Nachman; Martha G Sensel; Peter G Steinherz; Raymond J Hutchinson; Michael E Trigg; Gregory Reaman
Prognostic significance of the CD10+CD19+CD34+ B-progenitor immunophenotype in children with acute lymphoblastic leukemia: a report from the Children's Cancer Group.
Leukemia & lymphoma 1997;27(5-6):445-57.
1997: D Wang; Quanzhi Li; Wendy A Hudson; E Berven; fatih uckun; John H Kersey
Generation and characterization of an anti-CD19 single-chain Fv immunotoxin composed of C-terminal disulfide-linked dgRTA.
Bioconjugate chemistry 1997;8(6):878-84.
1997: Paul S Gaynon; A A Desai; Bruce C Bostrom; Raymond J Hutchinson; Beverly J Lange; James B Nachman; Gregory H Reaman; Harland Sather; Peter G Steinherz; Michael E Trigg; DG Tubergen; fatih uckun
Early response to therapy and outcome in childhood acute lymphoblastic leukemia: a review.
Cancer 1997;80(9):1717-26.
1997: DE Myers; X Jun; D Clementson; R Donelson; A Sicheneder; N Hoffman; K Bell; M Sarquis; MC Langlie; N Turner; fatih uckun
Large scale manufacturing of TXU(anti-CD7)-pokeweed antiviral protein (PAP) immunoconjugate for clinical trials.
Leukemia & lymphoma 1997;27(3-4):275-302.
1997: fatih uckun; Harland Sather; Paul S Gaynon; Diane C Arthur; Michael E Trigg; DG Tubergen; James B Nachman; Peter G Steinherz; Martha G Sensel; Gregory H Reaman
Clinical features and treatment outcome of children with myeloid antigen positive acute lymphoblastic leukemia: a report from the Children's Cancer Group.
Blood 1997;90(1):28-35.
1997: Barbara Waurzyniak; E A Schneider; N Tumer; Y Yanishevski; R Gunther; LM Chelstrom; H Wendorf; DE Myers; JD Irvin; Y Messinger; O Ek; T Zeren; MC Langlie; William Evans; fatih uckun
In vivo toxicity, pharmacokinetics, and antileukemic activity of TXU (anti-CD7)-pokeweed antiviral protein immunotoxin.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(6):881-90.
1997: Paul S Gaynon; ML Crotty; Harland Sather; Bruce C Bostrom; James B Nachman; Peter G Steinherz; Nyla A Heerema; MB Sarquis; L Tuel-Ahlgren; fatih uckun
Expression of BCR-ABL, E2A-PBX1, and MLL-AF4 fusion transcripts in newly diagnosed children with acute lymphoblastic leukemia: a Children's Cancer Group initiative.
Leukemia & lymphoma 1997;26(1-2):57-65.
1997: fatih uckun; Paul S Gaynon; Martha G Sensel; James B Nachman; Michael E Trigg; Peter G Steinherz; Raymond J Hutchinson; Bruce C Bostrom; Harland Sather; Gregory H Reaman
Clinical features and treatment outcome of childhood T-lineage acute lymphoblastic leukemia according to the apparent maturational stage of T-lineage leukemic blasts: a Children's Cancer Group study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(6):2214-21.
1997: fatih uckun; Z Yang; Harland Sather; Peter G Steinherz; James B Nachman; Bruce C Bostrom; L Crotty; MB Sarquis; O Ek; T Zeren; DG Tubergen; Gregory Reaman; Paul S Gaynon
Cellular expression of antiapoptotic BCL-2 oncoprotein in newly diagnosed childhood acute lymphoblastic leukemia: a Children's Cancer Group Study.
Blood 1997;89(10):3769-77.
1997: AE Bendel; Y Shao; S M Davies; BE Warman; C H Yang; KG Waddick; fatih uckun; JP Perentesis
A recombinant fusion toxin targeted to the granulocyte-macrophage colony-stimulating factor receptor.
Leukemia & lymphoma 1997;25(3-4):257-70.
1997: JP Perentesis; AE Bendel; Y Shao; BE Warman; S M Davies; C H Yang; M Chandan-Langlie; KG Waddick; fatih uckun
Granulocyte-macrophage colony-stimulating factor receptor-targeted therapy of chemotherapy- and radiation-resistant human myeloid leukemias.
Leukemia & lymphoma 1997;25(3-4):247-56.
1997: fatih uckun; Paul S Gaynon; Harland Sather; D Arthur; Michael E Trigg; DG Tubergen; James B Nachman; Peter G Steinherz; Martha G Sensel; G R Reaman
Clinical features and treatment outcome of children with biphenotypic CD2+ CD19+ acute lymphoblastic leukemia: a Children's Cancer Group study.
Blood 1997;89(7):2488-93.
1997: JP Perentesis; KG Waddick; AE Bendel; Y Shao; BE Warman; M Chandan-Langlie; fatih uckun
Induction of apoptosis in multidrug-resistant and radiation-resistant acute myeloid leukemia cells by a recombinant fusion toxin directed against the human granulocyte macrophage colony-stimulating factor receptor.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(3):347-55.
1997: fatih uckun; Y Yanishevski; N Tumer; Barbara Waurzyniak; Y Messinger; LM Chelstrom; Elizabeth Lisowski; O Ek; T Zeren; H Wendorf; MC Langlie; JD Irvin; DE Myers; G B Fuller; W Evans; R Gunther
Pharmacokinetic features, immunogenicity, and toxicity of B43(anti-CD19)-pokeweed antiviral protein immunotoxin in cynomolgus monkeys.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(3):325-37.
1997: KG Waddick; M Chandan-Langlie; fatih uckun
Differential effects of recombinant human granulocyte colony-stimulating factor (rhG-CSF) on the radiation sensitivity of normal versus leukemic bone marrow progenitor cell populations.
Leukemia & lymphoma 1997;25(1-2):77-90.
1997: Rainer W G Gruessner; fatih uckun; J Pirenne; Raouf E Nakhleh; Enrico Benedetti; I Bekersky; Christoph Troppmann; Angelika Gruessner
Recipient preconditioning and donor-specific bone marrow infusion in a pig model of total bowel transplantation.
Transplantation 1997;63(1):12-20.
1997: D Wang; E Berven; Quanzhi Li; fatih uckun; John H Kersey
Optimization of conditions for formation and analysis of anti-CD19 FVS191 single-chain Fv homodimer (scFv')2.
Bioconjugate chemistry 1997;8(1):64-70.
1997: J Pirenne; Angelika Gruessner; Enrico Benedetti; Christoph Troppmann; Raouf E Nakhleh; fatih uckun; Rainer W G Gruessner
Donor-specific unmodified bone marrow transfusion does not facilitate intestinal engraftment after bowel transplantation in a porcine model.
Surgery 1997;121(1):79-88.
1996: fatih uckun; Gregory Reaman; P G Steinherez; Diane C Arthur; Harland Sather; Michael E Trigg; DG Tubergen; Paul S Gaynon
Improved clinical outcome for children with T-lineage acute lymphoblastic leukemia after contemporary chemotherapy: a Children's Cancer Group Study.
Leukemia & lymphoma 1996;24(1-2):57-70.
1996: fatih uckun; Peter G Steinherz; Harland Sather; Michael E Trigg; D Arthur; DG Tubergen; Paul S Gaynon; Gregory Reaman
CD2 antigen expression on leukemic cells as a predictor of event-free survival after chemotherapy for T-lineage acute lymphoblastic leukemia: a Children's Cancer Group study.
Blood 1996;88(11):4288-95.
1996: Y Messinger; Y Yanishevski; V I Avramis; O Ek; LM Chelstrom; R Gunther; DE Myers; JD Irvin; W Evans; fatih uckun
Treatment of human B-cell precursor leukemia in SCID mice using a combination of the investigational biotherapeutic agent B43-PAP with cytosine arabinoside.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(9):1533-42.
1996: Y Messinger; LM Chelstrom; R Gunther; fatih uckun
Selective homing of human leukemic B-cell precursors to specific lymphohematopoietic microenvironments in SCID mice: a role for the beta 1 integrin family surface adhesion molecules VLA-4 and VLA-5.
Leukemia & lymphoma 1996;23(1-2):61-9.
1996: fatih uckun; KG Waddick; S Mahajan; X Jun; M Takata; J Bolen; T Kurosaki
BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells.
Science (New York, N.Y.) 1996;273(5278):1096-100.
1996: fatih uckun
Severe combined immunodeficient mouse models of human leukemia.
Blood 1996;88(4):1135-46.
1996: J Xiao; J E Biaglow; H J Chae-Park; J Jin; L Tuel-Ahlgren; DE Myers; A L Burkhardt; J B Bolen; fatih uckun
Role of hydroxyl radicals in radiation-induced activation of lyn tyrosine kinase in human B-cell precursors.
Leukemia & lymphoma 1996;22(5-6):421-30.
1996: DE Myers; M Chandan-Langlie; LM Chelstrom; fatih uckun
In vitro and in vivo anti-leukemic efficacy of cyclic AMP modulating agents against human leukemic B-cell precursors.
Leukemia & lymphoma 1996;22(3-4):259-64.
1996: R Gunther; LM Chelstrom; H R Wendorf; E A Schneider; K Covalciuc; B Johnson; D Clementson; JD Irvin; DE Myers; fatih uckun
Toxicity profile of the investigational new biotherapeutic agent, B43 (anti-CD19)-pokeweed antiviral protein immunotoxin.
Leukemia & lymphoma 1996;22(1-2):61-70, follow.186, color plate II-V.
1996: J Xiao; Y Messinger; J Jin; DE Myers; J B Bolen; fatih uckun
Signal transduction through the beta1 integrin family surface adhesion molecules VLA-4 and VLA-5 of human B-cell precursors activates CD19 receptor-associated protein-tyrosine kinases.
The Journal of biological chemistry 1996;271(13):7659-64.
1996: fatih uckun; L Tuel-Ahlgren; KG Waddick; X Jun; J Jin; DE Myers; R B Rowley; A L Burkhardt; J B Bolen
Physical and functional interactions between Lyn and p34cdc2 kinases in irradiated human B-cell precursors.
The Journal of biological chemistry 1996;271(11):6389-97.
1996: L Tuel-Ahlgren; X Jun; KG Waddick; J Jin; J Bolen; fatih uckun
Role of tyrosine phosphorylation in radiation-induced cell cycle-arrest of leukemic B-cell precursors at the G2-M transition checkpoint.
Leukemia & lymphoma 1996;20(5-6):417-26.
1996: M Smith; D Arthur; Bruce M Camitta; Andrew J Carroll; William M Crist; Paul S Gaynon; R Gelber; N Heerema; Edward L Korn; Michael Link; S Murphy; Ching-Hon Pui; Jeanette Pullen; G Reamon; Stephen E Sallan; Harland Sather; J Shuster; Richard Simon; Michael E Trigg; DG Tubergen; fatih uckun; R Ungerleider
Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(1):18-24.
1995: KG Waddick; DE Myers; R Gunther; LM Chelstrom; M Chandan-Langlie; JD Irvin; N Tumer; fatih uckun
In vitro and in vivo antileukemic activity of B43-pokeweed antiviral protein against radiation-resistant human B-cell precursor leukemia cells.
Blood 1995;86(11):4228-33.
1995: fatih uckun; T Kurosaki; J Jin; X Jun; A Morgan; M Takata; J Bolen; R Luben
Exposure of B-lineage lymphoid cells to low energy electromagnetic fields stimulates Lyn kinase.
The Journal of biological chemistry 1995;270(46):27666-70.
1995: DE Myers; X Jun; KG Waddick; C Forsyth; LM Chelstrom; R L Gunther; N E Tumer; J Bolen; fatih uckun
Membrane-associated CD19-LYN complex is an endogenous p53-independent and Bc1-2-independent regulator of apoptosis in human B-lineage lymphoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9575-9.
1995: KG Waddick; D M Finnegan; LM Chelstrom; fatih uckun
In vivo radiosensitizing effects of recombinant interleukin 6 on radiation resistant BCL-1 B-lineage leukemia cells in a murine syngeneic bone marrow transplant model system.
Leukemia & lymphoma 1995;19(1-2):121-8.
1995: Y Hur; D J Hwang; O Zoubenko; C Coetzer; fatih uckun; Nilgun E Tumer
Isolation and characterization of pokeweed antiviral protein mutations in Saccharomyces cerevisiae: identification of residues important for toxicity.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8448-52.
1995: fatih uckun; G H Reaman
Immunotoxins for treatment of leukemia and lymphoma.
Leukemia & lymphoma 1995;18(3-4):195-201.
1995: DE Myers; Y Yanishevski; E Masson; JD Irvin; William Evans; fatih uckun
Favorable pharmacodynamic features and superior anti-leukemic activity of B43 (anti-CD19) immunotoxins containing two pokeweed antiviral protein molecules covalently linked to each monoclonal antibody molecule.
Leukemia & lymphoma 1995;18(1-2):93-102.
1995: DE Myers; fatih uckun
An anti-CD72 immunotoxin against therapy-refractory B-lineage acute lymphoblastic leukemia.
Leukemia & lymphoma 1995;18(1-2):119-22.
1995: B E Bejcek; D Wang; E Berven; C A Pennell; Stephen Peiper; S Poppema; fatih uckun; J H Kersey
Development and characterization of three recombinant single chain antibody fragments (scFvs) directed against the CD19 antigen.
Cancer research 1995;55(11):2346-51.
1995: fatih uckun; C F Stewart; G Reaman; LM Chelstrom; J Jin; M Chandan-Langlie; KG Waddick; J White; William Evans
In vitro and in vivo activity of topotecan against human B-lineage acute lymphoblastic leukemia cells.
Blood 1995;85(10):2817-28.
1995: R Gunther; LM Chelstrom; L Tuel-Ahlgren; J Simon; DE Myers; fatih uckun
Biotherapy for xenografted human central nervous system leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19)-pokeweed antiviral protein immunotoxin.
Blood 1995;85(9):2537-45.
1995: P M Anderson; D E Meyers; DE Hasz; K Covalcuic; Daniel A Saltzman; C Khanna; fatih uckun
In vitro and in vivo cytotoxicity of an anti-osteosarcoma immunotoxin containing pokeweed antiviral protein.
Cancer research 1995;55(6):1321-7.
1995: fatih uckun; Harland Sather; Gregory Reaman; J Shuster; V Land; Michael E Trigg; R Gunther; LM Chelstrom; A Bleyer; Paul S Gaynon
Leukemic cell growth in SCID mice as a predictor of relapse in high-risk B-lineage acute lymphoblastic leukemia.
Blood 1995;85(4):873-8.
1995: fatih uckun; William Evans; C J Forsyth; KG Waddick; L T Ahlgren; LM Chelstrom; A Burkhardt; J Bolen; DE Myers
Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases.
Science (New York, N.Y.) 1995;267(5199):886-91.
1994: fatih uckun; James R Downing; LM Chelstrom; R Gunther; M Ryan; J Simon; A J Carroll; L Tuel-Ahlgren; W M Crist
Human t(4;11)(q21;q23) acute lymphoblastic leukemia in mice with severe combined immunodeficiency.
Blood 1994;84(3):859-65.
1994: C V Smith; T Sablinski; J Scott Arn; D E Myers; Bruce R Rosengard; fatih uckun; D H Sachs
In vivo treatment with monoclonal antibodies directed against CD4 and CD8 antigens in miniature swine.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1994;16(2):105-14.
1994: LM Chelstrom; R Gunther; J Simon; S C Raimondi; R Krance; W M Crist; fatih uckun
Childhood acute myeloid leukemia in mice with severe combined immunodeficiency.
Blood 1994;84(1):20-6.
1994: fatih uckun; M Chandan-Langlie; P A Dockham; D Aeppli; NE Sladek
Sensitivity of primary clonogenic blasts from acute lymphoblastic leukemia patients to an activated cyclophosphamide, viz., mafosfamide.
Leukemia & lymphoma 1994;13(5-6):417-28.
1994: C W Song; fatih uckun; S H Levitt; T H Kim
Comments on "Radiation dose-fractionation and dose-rate relationships for long-term repopulating hemopoietic stem cells in a murine bone marrow transplant model" by R. van Os, H. Thames, A. W. T. Konings and J. D. Down (Radiat. Res. 136, 118-125, 1993)
Radiation research 1994;137(3):414-6.
1994: Daniel J Weisdorf; William G Woods; M E Nesbit; fatih uckun; K Dusenbery; T Kim; R Haake; W Thomas; John H Kersey; Norma K C Ramsay
Allogeneic bone marrow transplantation for acute lymphoblastic leukaemia: risk factors and clinical outcome.
British journal of haematology 1994;86(1):62-9.
1993: KG Waddick; H P Chae; L Tuel-Ahlgren; L J Jarvis; Ilker Dibirdik; DE Myers; fatih uckun
Engagement of the CD19 receptor on human B-lineage leukemia cells activates LCK tyrosine kinase and facilitates radiation-induced apoptosis.
Radiation research 1993;136(3):313-9.
1993: fatih uckun; D Aeppli; Chang W Song
Radiation resistance of primary clonogenic blasts from children with acute lymphoblastic leukemia.
International journal of radiation oncology, biology, physics 1993;27(4):899-906.
1993: fatih uckun
Immunotoxins for the treatment of leukaemia.
British journal of haematology 1993;85(3):435-8.
1993: fatih uckun; J H Kersey; R Haake; Daniel Weisdorf; M E Nesbit; N K Ramsay
Pretransplantation burden of leukemic progenitor cells as a predictor of relapse after bone marrow transplantation for acute lymphoblastic leukemia.
The New England journal of medicine 1993;329(18):1296-301.
1993: fatih uckun; A L Burkhardt; L Jarvis; X Jun; B Stealey; Ilker Dibirdik; DE Myers; L Tuel-Ahlgren; J B Bolen
Signal transduction through the CD19 receptor during discrete developmental stages of human B-cell ontogeny.
The Journal of biological chemistry 1993;268(28):21172-84.
1993: G L Schieven; J M Kirihara; DE Myers; Jeffrey A Ledbetter; fatih uckun
Reactive oxygen intermediates activate NF-kappa B in a tyrosine kinase-dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes.
Blood 1993;82(4):1212-20.
1993: fatih uckun; James R Downing; R Gunther; LM Chelstrom; D Finnegan; V J Land; Michael J Borowitz; A J Carroll; W M Crist
Human t(1;19)(q23;p13) pre-B acute lymphoblastic leukemia in mice with severe combined immunodeficiency.
Blood 1993;81(11):3052-62.
1993: KG Waddick; fatih uckun
CD5 antigen-positive B lymphocytes in human B cell ontogeny during fetal development and after autologous bone marrow transplantation.
Experimental hematology 1993;21(6):791-8.
1993: G L Schieven; J M Kirihara; L K Gilliland; fatih uckun; Jeffrey A Ledbetter
Ultraviolet radiation rapidly induces tyrosine phosphorylation and calcium signaling in lymphocytes.
Molecular biology of the cell 1993;4(5):523-30.
1993: Alejo Erice; Henry H Balfour; DE Myers; V L Leske; K J Sannerud; V Kuebelbeck; JD Irvin; fatih uckun
Anti-human immunodeficiency virus type 1 activity of an anti-CD4 immunoconjugate containing pokeweed antiviral protein.
Antimicrobial agents and chemotherapy 1993;37(4):835-8.
1993: fatih uckun; DE Myers; JD Irvin; V M Kuebelbeck; D Finnegan; LM Chelstrom; L L Houston
Effects of the intermolecular toxin-monoclonal antibody linkage on the in vivo stability, immunogenicity and anti-leukemic activity of B43 (anti-CD19) pokeweed antiviral protein immunotoxin.
Leukemia & lymphoma 1993;9(6):459-76.
1993: fatih uckun; M Chandan-Langlie; WB Jaszcz; V Obuz; KG Waddick; Chang W Song
Radiation damage repair capacity of primary clonogenic blasts in acute lymphoblastic leukemia.
Cancer research 1993;53(6):1431-6.
1993: fatih uckun; WB Jaszcz; M Chandan-Langlie; KG Waddick; K Gajl-Peczalska; Chang W Song
Intrinsic radiation resistance of primary clonogenic blasts from children with newly diagnosed B-cell precursor acute lymphoblastic leukemia.
The Journal of clinical investigation 1993;91(3):1044-51.
1993: fatih uckun; Chang W Song
Lack of CD24 antigen expression in B-lineage acute lymphoblastic leukemia is associated with intrinsic radiation resistance of primary clonogenic blasts.
Blood 1993;81(5):1323-32.
1993: H P Chae; L J Jarvis; fatih uckun
Role of tyrosine phosphorylation in radiation-induced activation of c-jun protooncogene in human lymphohematopoietic precursor cells.
Cancer research 1993;53(3):447-51.
1993: fatih uckun; A Frankel
The current status of immunotoxins: an overview of experimental and clinical studies as presented at the Third International Symposium on Immunotoxins.
Leukemia 1993;7(2):341-8.
1993: R Gunther; LM Chelstrom; D Finnegan; L Tuel-Ahlgren; JD Irvin; DE Myers; fatih uckun
In vivo anti-leukemic efficacy of anti-CD7-pokeweed antiviral protein immunotoxin against human T-lineage acute lymphoblastic leukemia/lymphoma in mice with severe combined immunodeficiency.
Leukemia 1993;7(2):298-309.
1993: B Jansen; John H Kersey; W B Jaszcz; R Gunther; D P Nguyen; LM Chelstrom; L Tuel-Ahlgren; fatih uckun
Effective immunochemotherapy of human t(4;11) leukemia in mice with severe combined immunodeficiency (SCID) using B43 (anti-CD19)-pokeweed antiviral protein immunotoxin plus cyclophosphamide.
Leukemia 1993;7(2):290-7.
1993: Daniel J Weisdorf; P M Anderson; Bruce R Blazar; fatih uckun; J H Kersey; Norma K C Ramsay
Interleukin 2 immediately after autologous bone marrow transplantation for acute lymphoblastic leukemia--a phase I study.
Transplantation 1993;55(1):61-6.
1993: fatih uckun; G L Schieven; L M Tuel-Ahlgren; Ilker Dibirdik; DE Myers; Jeffrey A Ledbetter; Chang W Song
Tyrosine phosphorylation is a mandatory proximal step in radiation-induced activation of the protein kinase C signaling pathway in human B-lymphocyte precursors.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(1):252-6.
1993: fatih uckun; DE Myers
Allograft and autograft purging using immunotoxins in clinical bone marrow transplantation for hematologic malignancies.
Journal of hematotherapy 1993;2(2):155-63.
1992: P M Anderson; W Crist; DE Hasz; A J Carroll; D E Myers; fatih uckun
G19.4(alpha CD3) x B43(alpha CD19) monoclonal antibody heteroconjugate triggers CD19 antigen-specific lysis of t(4;11) acute lymphoblastic leukemia cells by activated CD3 antigen-positive cytotoxic T cells.
Blood 1992;80(11):2826-34.
1992: fatih uckun; L Tuel-Ahlgren; Chang W Song; KG Waddick; DE Myers; J Kirihara; Jeffrey A Ledbetter; G L Schieven
Ionizing radiation stimulates unidentified tyrosine-specific protein kinases in human B-lymphocyte precursors, triggering apoptosis and clonogenic cell death.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):9005-9.
1992: fatih uckun; S Haissig; Jeffrey A Ledbetter; P Fidler; DE Myers; V Kuebelbeck; Daniel Weisdorf; K Gajl-Peczalska; J H Kersey; Norma K C Ramsay
Developmental hierarchy during early human B-cell ontogeny after autologous bone marrow transplantation using autografts depleted of CD19+ B-cell precursors by an anti-CD19 pan-B-cell immunotoxin containing pokeweed antiviral protein.
Blood 1992;79(12):3369-79.
1992: fatih uckun; LM Chelstrom; D Finnegan; L Tuel-Ahlgren; C Manivel; JD Irvin; DE Myers; R Gunther
Effective immunochemotherapy of CALLA+C mu+ human pre-B acute lymphoblastic leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19) pokeweed antiviral protein immunotoxin plus cyclophosphamide.
Blood 1992;79(12):3116-29.
1992: fatih uckun; LM Chelstrom; JD Irvin; D Finnegan; R Gunther; J Young; V Kuebelbeck; DE Myers; L L Houston
In vivo efficacy of B43 (anti-CD19)-pokeweed antiviral protein immunotoxin against BCL-1 murine B-cell leukemia.
Blood 1992;79(10):2649-61.
1992: fatih uckun; C Manivel; D Arthur; LM Chelstrom; D Finnegan; L Tuel-Ahlgren; JD Irvin; DE Myers; R Gunther
In vivo efficacy of B43 (anti-CD19)-pokeweed antiviral protein immunotoxin against human pre-B cell acute lymphoblastic leukemia in mice with severe combined immunodeficiency.
Blood 1992;79(9):2201-14.
1992: LM Chelstrom; D Finnegan; fatih uckun
Treatment of BCL-1 murine B-cell leukemia with recombinant cytokines. Comparative analysis of the anti-leukemic potential of interleukin 1 beta (IL-1 beta), interleukin 2 (IL-2), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF alpha), granulocyte colony stimulating factor (G-CSF), granulocyte-macrophage colony stimulating factor (GM-CSF), and their combination.
Leukemia & lymphoma 1992;7(1-2):79-86.
1992: fatih uckun; John H Kersey; R Haake; Daniel Weisdorf; Norma K C Ramsay
Autologous bone marrow transplantation in high-risk remission B-lineage acute lymphoblastic leukemia using a cocktail of three monoclonal antibodies (BA-1/CD24, BA-2/CD9, and BA-3/CD10) plus complement and 4-hydroperoxycyclophosphamide for ex vivo bone marrow purging.
Blood 1992;79(4):1094-104.
1992: B Jansen; fatih uckun; W B Jaszcz; John H Kersey
Establishment of a human t(4;11) leukemia in severe combined immunodeficient mice and successful treatment using anti-CD19 (B43)-pokeweed antiviral protein immunotoxin.
Cancer research 1992;52(2):406-12.
1992: J Kersey; Daniel Weisdorf; fatih uckun; D Vallera; B Jansen; M Nesbit; R Haake; Norma K C Ramsay
Allogeneic and autologous bone marrow transplantation for high risk acute lymphoblastic leukemia.
Leukemia 1992;6 Suppl 2():191-2.
1992: fatih uckun; J B Mitchell; V Obuz; M Chandan-Langlie; W S Min; S Haissig; Chang W Song
Radiation and heat sensitivity of human T-lineage acute lymphoblastic leukemia (ALL) and acute myeloblastic leukemia (AML) clones displaying multiple drug resistance (MDR).
International journal of radiation oncology, biology, physics 1992;23(1):115-25.
1992: J D Irvin; fatih uckun
Pokeweed antiviral protein: ribosome inactivation and therapeutic applications.
Pharmacology & therapeutics 1992;55(3):279-302.
1992: fatih uckun; Chang W Song; M Nesbit; J H Kersey; Norma K C Ramsay
Immunophenotype predicts radiation resistance in T-lineage acute lymphoblastic leukemia and T-lineage non-Hodgkin's lymphoma.
International journal of radiation oncology, biology, physics 1992;24(4):705-12.
1991: fatih uckun; Norma K C Ramsay; KG Waddick; WB Jaszcz; M Chandan-Langlie; V Obuz; R Haake; K Gajl-Peczalska; John H Kersey; Chang W Song
In vitro and in vivo radiation resistance associated with CD3 surface antigen expression in T-lineage acute lymphoblastic leukemia.
Blood 1991;78(11):2945-55.
1991: fatih uckun; J B Mitchell; V Obuz; C H Park; KG Waddick; N Friedman; L Oubaha; W S Min; Chang W Song
Radiation sensitivity of human B-lineage lymphoid precursor cells.
International journal of radiation oncology, biology, physics 1991;21(6):1553-60.
1991: fatih uckun; G L Schieven; Ilker Dibirdik; M Chandan-Langlie; L Tuel-Ahlgren; Jeffrey A Ledbetter
Stimulation of protein tyrosine phosphorylation, phosphoinositide turnover, and multiple previously unidentified serine/threonine-specific protein kinases by the Pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny.
The Journal of biological chemistry 1991;266(26):17478-85.
1991: Ilker Dibirdik; MC Langlie; Jeffrey A Ledbetter; L Tuel-Ahlgren; V Obuz; KG Waddick; K Gajl-Peczalska; G L Schieven; fatih uckun
Engagement of interleukin-7 receptor stimulates tyrosine phosphorylation, phosphoinositide turnover, and clonal proliferation of human T-lineage acute lymphoblastic leukemia cells.
Blood 1991;78(3):564-70.
1991: fatih uckun; L Tuel-Ahlgren; V Obuz; R Smith; Ilker Dibirdik; M Hanson; MC Langlie; Jeffrey A Ledbetter
Interleukin 7 receptor engagement stimulates tyrosine phosphorylation, inositol phospholipid turnover, proliferation, and selective differentiation to the CD4 lineage by human fetal thymocytes.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(14):6323-7.
1991: KG Waddick; Chang W Song; L Souza; fatih uckun
Comparative analysis of the in vivo radioprotective effects of recombinant granulocyte colony-stimulating factor (G-CSF), recombinant granulocyte-macrophage CSF, and their combination.
Blood 1991;77(11):2364-71.
1991: fatih uckun; Ilker Dibirdik; R Smith; L Tuel-Ahlgren; M Chandan-Langlie; G L Schieven; KG Waddick; M Hanson; Jeffrey A Ledbetter
Interleukin 7 receptor ligation stimulates tyrosine phosphorylation, inositol phospholipid turnover, and clonal proliferation of human B-cell precursors.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(9):3589-93.
1991: L K Gilliland; Hung-Sia Teh; fatih uckun; N A Norris; Soo-Jeet Teh; G L Schieven; Jeffrey A Ledbetter
CD4 and CD8 are positive regulators of T cell receptor signal transduction in early T cell differentiation.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(6):1759-65.
1991: J A Ledbetter; G L Schieven; V M Kuebelbeck; fatih uckun
Accessory receptors regulate coupling of the T-cell receptor complex to tyrosine kinase activation and mobilization of cytoplasmic calcium in T-lineage acute lymphoblastic leukemia.
Blood 1991;77(6):1271-82.
1991: J A Ledbetter; G L Schieven; fatih uckun; J B Imboden
CD45 cross-linking regulates phospholipase C activation and tyrosine phosphorylation of specific substrates in CD3/Ti-stimulated T cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(5):1577-83.
1991: DE Myers; JD Irvin; R S Smith; V M Kuebelbeck; fatih uckun
Production of a pokeweed antiviral protein (PAP)-containing immunotoxin, B43-PAP, directed against the CD19 human B lineage lymphoid differentiation antigen in highly purified form for human clinical trials.
Journal of immunological methods 1991;136(2):221-37.
1991: J M Zarling; P A Moran; Omar Haffar; M Diegel; DE Myers; V Kuelbeck; Jeffrey A Ledbetter; fatih uckun
Inhibition of HIV-1 replication in seropositive patients' CD4+ T-cells by pokeweed antiviral protein-monoclonal antibody conjugates.
International journal of immunopharmacology 1991;13 Suppl 1():63-8.
1990: fatih uckun; K Gajl-Peczalska; DE Myers; WB Jaszcz; S Haissig; Jeffrey A Ledbetter
Temporal association of CD40 antigen expression with discrete stages of human B-cell ontogeny and the efficacy of anti-CD40 immunotoxins against clonogenic B-lineage acute lymphoblastic leukemia as well as B-lineage non-Hodgkin's lymphoma cells.
Blood 1990;76(12):2449-56.
1990: fatih uckun
Regulation of human B-cell ontogeny.
Blood 1990;76(10):1908-23.
1990: fatih uckun; J H Kersey; D A Vallera; Jeffrey A Ledbetter; Daniel Weisdorf; DE Myers; R Haake; Norma K C Ramsay
Autologous bone marrow transplantation in high-risk remission T-lineage acute lymphoblastic leukemia using immunotoxins plus 4-hydroperoxycyclophosphamide for marrow purging.
Blood 1990;76(9):1723-33.
1990: J M Zarling; P A Moran; Omar Haffar; J Sias; D D Richman; C A Spina; DE Myers; V Kuebelbeck; Jeffrey A Ledbetter; fatih uckun
Inhibition of HIV replication by pokeweed antiviral protein targeted to CD4+ cells by monoclonal antibodies.
Nature 1990;347(6288):92-5.
1990: William G Woods; Norma K C Ramsay; Daniel J Weisdorf; R Haake; D A Vallera; T H Kim; L Lasky; M E Nesbit; Bruce C Bostrom; fatih uckun
Bone marrow transplantation for acute lymphocytic leukemia utilizing total body irradiation followed by high doses of cytosine arabinoside: lack of superiority over cyclophosphamide-containing conditioning regimens.
Bone marrow transplantation 1990;6(1):9-16.
1990: fatih uckun; L Souza; KG Waddick; M Wick; Chang W Song
In vivo radioprotective effects of recombinant human granulocyte colony-stimulating factor in lethally irradiated mice.
Blood 1990;75(3):638-45.
1990: Daniel Weisdorf; Norma K C Ramsay; T LeBien; W Woods; Bruce C Bostrom; M Nesbit; D Vallera; fatih uckun; A Goldman; T Kim
Allogeneic and autologous bone marrow transplantation for acute lymphoblastic leukemia.
Haematology and blood transfusion 1990;33():679-83.
1990: D A Vallera; fatih uckun
Bone marrow purging with immunotoxins for treatment of T cell acute lymphoblastic leukemia (T-ALL).
Progress in clinical and biological research 1990;333():191-204; discussion 205.
1990: W S Min; Chang W Song; fatih uckun
Thermal sensitivity and thermal tolerance of human B-lineage acute lymphoblastic leukemia (ALL) cells.
International journal of radiation oncology, biology, physics 1990;18(1):147-53.
1989: fatih uckun; D E Myers; Jeffrey A Ledbetter; S L Wee; D A Vallera
Cell-type-specific cytotoxicity of anti-CD4 and anti-CD8 ricin immunotoxins against human alloreactive T-cell clones.
Blood 1989;74(7):2445-54.
1989: fatih uckun; Anthony Fauci; M Chandan-Langlie; DE Myers; J L Ambrus
Detection and characterization of human high molecular weight B cell growth factor receptors on leukemic B cells in chronic lymphocytic leukemia.
The Journal of clinical investigation 1989;84(5):1595-608.
1989: fatih uckun; Chang W Song
Radiobiological features of human pluripotent bone marrow progenitor cells (CFU-GEMM).
International journal of radiation oncology, biology, physics 1989;17(5):1021-5.
1989: fatih uckun; T H Kim; N C Ramsay; W S Min; Chang W Song
Radiobiological heterogeneity of leukemic lymphocyte precursors from acute lymphoblastic leukemia patients.
International journal of radiation biology 1989;56(5):611-5.
1989: fatih uckun; DE Myers; Anthony Fauci; M Chandan-Langlie; J L Ambrus
Leukemic B-cell precursors constitutively express functional receptors for human interleukin-1.
Blood 1989;74(2):761-76.
1989: D E Myers; fatih uckun; S E Swaim; D A Vallera
The effects of aromatic and aliphatic maleimide crosslinkers on anti-CD5 ricin immunotoxins.
Journal of immunological methods 1989;121(1):129-42.
1989: fatih uckun; A Muraguchi; Jeffrey A Ledbetter; T Kishimoto; R T O'Brien; J S Roloff; K Gajl-Peczalska; A Provisor; B Koller
Biphenotypic leukemic lymphocyte precursors in CD2+CD19+ acute lymphoblastic leukemia and their putative normal counterparts in human fetal hematopoietic tissues.
Blood 1989;73(4):1000-15.
1989: Jeffrey A Ledbetter; N A Norris; A Grossmann; LS Grosmaire; C H June; fatih uckun; W L Cosand; P S Rabinovitch
Enhanced transmembrane signalling activity of monoclonal antibody heteroconjugates suggests molecular interactions between receptors on the T cell surface.
Molecular immunology 1989;26(2):137-45.
1989: fatih uckun; T G Gesner; Chang W Song; DE Myers; A Mufson
Leukemic B-cell precursors express functional receptors for human interleukin-3.
Blood 1989;73(2):533-42.
1989: fatih uckun; S Gillis; L Souza; C W Song
Effects of recombinant growth factors on radiation survival of human bone marrow progenitor cells.
International journal of radiation oncology, biology, physics 1989;16(2):415-35.
1989: fatih uckun; K J Gajl-Peczalska; A J Provisor; N A Heerema
Immunophenotype-karyotype associations in human acute lymphoblastic leukemia.
Blood 1989;73(1):271-80.
1988: fatih uckun; Jeffrey A Ledbetter
Immunobiologic differences between normal and leukemic human B-cell precursors.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(22):8603-7.
1988: fatih uckun; Chang W Song
Radiobiological features of fresh leukemic bone marrow progenitor cells in acute lymphoblastic leukemia.
Cancer research 1988;48(20):5788-95.
1988: D E Myers; fatih uckun; E D Ball; D A Vallera
Immunotoxins for ex vivo marrow purging in autologous bone marrow transplantation for acute nonlymphocytic leukemia.
Transplantation 1988;46(2):240-5.
1988: fatih uckun; D E Myers; J A Ledbetter; S E Swaim; K J Gajl-Peczalska; D A Vallera
Use of colony assays and anti-T cell immunotoxins to elucidate the immunobiologic features of leukemic progenitor cells in T-lineage acute lymphoblastic leukemia.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(6):2103-11.
1988: J A Ledbetter; P S Rabinovitch; C H June; C W Song; E A Clark; fatih uckun
Antigen-independent regulation of cytoplasmic calcium in B cells with a 12-kDa B-cell growth factor and anti-CD19.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(6):1897-901.
1988: fatih uckun; WB Jaszcz; J L Ambrus; Anthony Fauci; K Gajl-Peczalska; Chang W Song; M R Wick; DE Myers; KG Waddick; Jeffrey A Ledbetter
Detailed studies on expression and function of CD19 surface determinant by using B43 monoclonal antibody and the clinical potential of anti-CD19 immunotoxins.
Blood 1988;71(1):13-29.
1987: fatih uckun; Anthony Fauci; N A Heerema; Chang W Song; S R Mehta; K Gajl-Peczalska; M Chandan; J L Ambrus
B-cell growth factor receptor expression and B-cell growth factor response of leukemic B cell precursors and B lineage lymphoid progenitor cells.
Blood 1987;70(4):1020-34.
1987: fatih uckun; J H Kersey; K J Gajl-Peczalska; N A Heerema; A J Provisor; D Haag; G Gilchrist; Chang W Song; D C Arthur; J Roloff
Heterogeneity of cultured leukemic lymphoid progenitor cells from B cell precursor acute lymphoblastic leukemia (ALL) patients.
The Journal of clinical investigation 1987;80(3):639-46.
1987: G Weil-Hillman; fatih uckun; J M Manske; D A Vallera
Combined immunochemotherapy of human solid tumors in nude mice.
Cancer research 1987;47(2):579-85.
1987: fatih uckun; K Gajl-Peczalska; D E Meyers; N C Ramsay; J H Kersey; M Colvin; D A Vallera
Marrow purging in autologous bone marrow transplantation for T-lineage acute lymphoblastic leukemia: efficacy of ex vivo treatment with immunotoxins and 4-hydroperoxycyclophosphamide against fresh leukemic marrow progenitor cells.
Blood 1987;69(1):361-6.
1986: fatih uckun; K J Gajl-Peczalska; J H Kersey; L L Houston; D A Vallera
Use of a novel colony assay to evaluate the cytotoxicity of an immunotoxin containing pokeweed antiviral protein against blast progenitor cells freshly obtained from patients with common B-lineage acute lymphoblastic leukemia.
The Journal of experimental medicine 1986;163(2):347-68.
1986: T W LeBien; J M Anderson; D A Vallera; fatih uckun
Increased efficacy in selective elimination of leukemic cell line clonogenic cells by a combination of monoclonal antibodies BA-1, BA-2, BA-3 + complement and mafosfamid (ASTA Z 7557).
Leukemia research 1986;10(2):139-43.
1986: fatih uckun; S M Azemove; D E Myers; D A Vallera
Anti-CD2 (T, p50) intact ricin immunotoxins for GVHD-prophylaxis in allogeneic bone marrow transplantation.
Leukemia research 1986;10(2):145-53.
1986: R J Youle; fatih uckun; D A Vallera; M Colombatti
Immunotoxins show rapid entry of diphtheria toxin but not ricin via the T3 antigen.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(1):93-8.
1985: fatih uckun; D A Vallera; S L Wee
B lymphocyte regulation of human hematopoiesis.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(6):3817-22.
1985: S Ramakrishnan; fatih uckun; L L Houston
Anti-T cell immunotoxins containing pokeweed anti-viral protein: potential purging agents for human autologous bone marrow transplantation.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(5):3616-22.
1985: fatih uckun; R C Stong; R J Youle; D A Vallera
Combined ex vivo treatment with immunotoxins and mafosfamid: a novel immunochemotherapeutic approach for elimination of neoplastic T cells from autologous marrow grafts.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(5):3504-15.
1985: fatih uckun; S Ramakrishnan; L L Houston
Immunotoxin-mediated elimination of clonogenic tumor cells in the presence of human bone marrow.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(3):2010-6.
1985: fatih uckun; S Ramakrishnan; D Haag; L L Houston
Ex vivo elimination of lymphoblastic leukemia cells from human marrow by mafosfamid.
Leukemia research 1985;9(1):83-95.
1985: fatih uckun; S Ramakrishnan; L L Houston
Ex vivo elimination of neoplastic T-cells from human marrow using an anti-Mr 41,000 protein immunotoxin: potentiation by ASTA Z 7557.
Blut 1985;50(1):19-23.
1985: fatih uckun; S Ramakrishnan; L L Houston
Increased efficiency in selective elimination of leukemia cells by a combination of a stable derivative of cyclophosphamide and a human B-cell-specific immunotoxin containing pokeweed antiviral protein.
Cancer research 1985;45(1):69-75.