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Worek Franz

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François Estour; R K Kalakuntla; Olivier Lafont; R Le Provost; S Letort; S Müller; G Reiter; T Wille; Worek Franz; G Gouhier
Functionalized cyclodextrins bearing an alpha nucleophile--a promising way to degrade nerve agents.
Worek Franz; Timo Wille; Marianne Koller; Horst Thiermann
Structural requirements for effective oximes--evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes.
Raman Kumar Kalakuntla; Olivier Lafont; Romain Le Provost; Sophie Letort; Susanne Müller; Georg Reiter; Horst Thiermann; Timo Wille; Worek Franz; Géraldine Gouhier; François Estour
New modified β-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (I). Synthesis and preliminary screening: evaluation of the detoxification using a half-quantitative enzymatic assay.

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2013: François Estour; R K Kalakuntla; Olivier Lafont; R Le Provost; S Letort; S Müller; G Reiter; T Wille; Worek Franz; G Gouhier
Functionalized cyclodextrins bearing an alpha nucleophile--a promising way to degrade nerve agents.
Chemico-biological interactions 2013;203(1):202-7.
2013: Worek Franz; Timo Wille; Marianne Koller; Horst Thiermann
Structural requirements for effective oximes--evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes.
Chemico-biological interactions 2013;203(1):125-8.
2013: Raman Kumar Kalakuntla; Olivier Lafont; Romain Le Provost; Sophie Letort; Susanne Müller; Georg Reiter; Horst Thiermann; Timo Wille; Worek Franz; Géraldine Gouhier; François Estour
New modified β-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (I). Synthesis and preliminary screening: evaluation of the detoxification using a half-quantitative enzymatic assay.
Toxicology letters 2013;216(2-3):200-5.
2013: Susanne Müller; Horst Thiermann; Worek Franz; François Estour; Raman Kumar Kalakuntla; Olivier Lafont; Romain Le Provost; Georg Reiter
New modified β-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (II). In vitro detoxification of cyclosarin (GF): general screening and toxicokinetic aspects of OP scavengers.
Toxicology letters 2013;216(2-3):206-12.
2012: Florian Brandhuber; Stefan Kubik; Luzian Porwol; Oliver Tenberken; Horst Thiermann; Worek Franz; Michael Zengerle; Georg Reiter
Detoxification of tabun at physiological pH mediated by substituted β-cyclodextrin and glucose derivatives containing oxime groups.
Toxicology 2012;302(2-3):163-71.
2012: Worek Franz; Jens von der Wellen; Kamil Kuca; Kamil Musilek; Horst Thiermann
Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase.
Archives of toxicology 2012;86(9):1379-86.
2012: T Seeger; J E H Tattersall; Horst Thiermann; C M Timperley; M Bird; M Eichhorn; A C Green; M Lindner; K V Niessen; Worek Franz
Restoration of soman-blocked neuromuscular transmission in human and rat muscle by the bispyridinium non-oxime MB327 in vitro.
Toxicology 2012;294(2-3):80-4.
2012: Nadja M Herkert; Ulrich Kunz; Horst Thiermann; Gregor Freude; Worek Franz
Comparative kinetics of organophosphates and oximes with erythrocyte, muscle and brain acetylcholinesterase.
Toxicology letters 2012;209(2):173-8.
2012: K V Niessen; J E H Tattersall; Horst Thiermann; C M Timperley; M Bird; C Green; Worek Franz
Competition radioligand binding assays for the investigation of bispyridinium compound affinities to the human muscarinic acetylcholine receptor subtype 5 (hM(5) ).
Drug testing and analysis 2012;4(3-4):292-7.
2012: Reinhard Bogan; Marianne Koller; Worek Franz; Bernd Klaubert
Photostability of antidotal oxime HI-6, impact on drug development.
Drug testing and analysis 2012;4(3-4):208-14.
2012: Harald John; R Eddie Clutton; Michael Eddleston; Worek Franz; Horst Thiermann
Quantification of pralidoxime (2-PAM) in urine by ion pair chromatography-diode array detection: application to in vivo samples from minipig.
Drug testing and analysis 2012;4(3-4):169-78.
2012: Worek Franz; Peter Eyer; Horst Thiermann
Determination of acetylcholinesterase activity by the Ellman assay: a versatile tool for in vitro research on medical countermeasures against organophosphate poisoning.
Drug testing and analysis 2012;4(3-4):282-91.
2012: Harald John; John Mikler; Worek Franz; Horst Thiermann
Application of an enantioselective LC-ESI MS/MS procedure to determine R- and S-hyoscyamine following intravenous atropine administration in swine.
Drug testing and analysis 2012;4(3-4):194-8.
2011: Worek Franz; Horst Thiermann
Reactivation of organophosphate-inhibited human acetylcholinesterase by isonitrosoacetone (MINA): a kinetic analysis.
Chemico-biological interactions 2011;194(2-3):91-6.
2011: T Seeger; Worek Franz; R Bumm; H Friess; J Gerhardus; P Langer; A L Mihaljevic; K V Niessen; Horst Thiermann
Restoration of nerve agent inhibited muscle force production in human intercostal muscle strips with HI 6.
Toxicology letters 2011;206(1):72-6.
2011: Horst Thiermann; Worek Franz; Florian Eyer; Peter Eyer; Norbert Felgenhauer; Maria Radtke; Dirk Steinritz; Thomas Zilker
Atropine maintenance dosage in patients with severe organophosphate pesticide poisoning.
Toxicology letters 2011;206(1):77-83.
2011: Tanja Klein-Rodewald; Thomas Seeger; Worek Franz; Mathias Dutschmann; Michael Mörschel
Central respiratory effects on motor nerve activities after organophosphate exposure in a working heart brainstem preparation of the rat.
Toxicology letters 2011;206(1):94-9.
2011: Miriam Dadparvar; Jürgen Kufleitner; Hagen von Briesen; Sylvia Wagner; Sascha Wien; Worek Franz; Jörg Kreuter
HI 6 human serum albumin nanoparticles--development and transport over an in vitro blood-brain barrier model.
Toxicology letters 2011;206(1):60-6.
2011: John Mikler; G Reiter; S Bohnert; M Garrett; Catherine Tenn; Horst Thiermann; Worek Franz; T W Sawyer
Immobilization of Russian VX skin depots by localized cooling: implications for decontamination and medical countermeasures.
Toxicology letters 2011;206(1):47-53.
2011: K V Niessen; T Seeger; J E H Tattersall; Horst Thiermann; C M Timperley; M Bird; C Green; Worek Franz
Interaction of bispyridinium compounds with the orthosteric binding site of human α7 and Torpedo californica nicotinic acetylcholine receptors (nAChRs).
Toxicology letters 2011;206(1):100-4.
2011: Oliver Tenberken; Worek Franz; Horst Thiermann
Thirteenth International Medical Chemical Defence Conference 2011 "New developments in the treatment of intoxications by chemical warfare agents with focus on neurotoxic agents".
Toxicology letters 2011;206(1):3-4.
2011: N M Herkert; Horst Thiermann; Worek Franz
In vitro kinetic interactions of pyridostigmine, physostigmine and soman with erythrocyte and muscle acetylcholinesterase from different species.
Toxicology letters 2011;206(1):41-6.
2011: Georg Reiter; Horst Thiermann; Kendal Weatherby; Ira Hill; John Mikler; Worek Franz
Simultaneous quantification of VX and its toxic metabolite in blood and plasma samples and its application for in vivo and in vitro toxicological studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011;879(26):2704-13.
2011: T W Sawyer; John Mikler; Worek Franz; G Reiter; Horst Thiermann; C Tenn; K Weatherby; S Bohnert
The therapeutic use of localized cooling in the treatment of VX poisoning.
Toxicology letters 2011;204(1):52-6.
2011: Worek Franz; Nadine Aurbek; Timo Wille; Peter Eyer; Horst Thiermann
Kinetic prerequisites of oximes as effective reactivators of organophosphate-inhibited acetylcholinesterase: a theoretical approach.
Journal of enzyme inhibition and medicinal chemistry 2011;26(3):303-8.
2011: N M Herkert; S Schulz; T Wille; Horst Thiermann; Rudolf A. Hatz; Worek Franz
Pre- and post-treatment effect of physostigmine on soman-inhibited human erythrocyte and muscle acetylcholinesterase in vitro.
Toxicology and applied pharmacology 2011;253(1):7-13.
2011: Timo Wille; Horst Thiermann; Worek Franz
In vitro kinetic interactions of DEET, pyridostigmine and organophosphorus pesticides with human cholinesterases.
Chemico-biological interactions 2011;190(2-3):79-83.
2011: T Wille; Horst Thiermann; Worek Franz
Effect of different buffers on kinetic properties of human acetylcholinesterase and the interaction with organophosphates and oximes.
Archives of toxicology 2011;85(3):193-8.
2011: Susanne Müller; Marianne Koller; Romain Le Provost; Olivier Lafont; François Estour; Timo Wille; Horst Thiermann; Worek Franz; Georg Reiter
In vitro detoxification of cyclosarin (GF) by modified cyclodextrins.
Toxicology letters 2011;200(1-2):53-8.
2011: Worek Franz; Nadine Aurbek; Timo Wille; Peter Eyer; Horst Thiermann
Kinetic analysis of interactions of paraoxon and oximes with human, Rhesus monkey, swine, rabbit, rat and guinea pig acetylcholinesterase.
Toxicology letters 2011;200(1-2):19-23.
2010: Worek Franz; Timo Wille; Nadine Aurbek; Peter Eyer; Horst Thiermann
Reactivation of organophosphate-inhibited human, Cynomolgus monkey, swine and guinea pig acetylcholinesterase by MMB-4: a modified kinetic approach.
Toxicology and applied pharmacology 2010;249(3):231-7.
2010: Luigia Merone; Luigi Mandrich; ELENA PORZIO; Mosé Rossi; Susanne Müller; Georg Reiter; Worek Franz; Giuseppe Manco
Improving the promiscuous nerve agent hydrolase activity of a thermostable archaeal lactonase.
Bioresource technology 2010;101(23):9204-12.
2010: Oliver Tenberken; John Mikler; I Hill; K Weatherby; Horst Thiermann; Worek Franz; G Reiter
Toxicokinetics of tabun enantiomers in anaesthetized swine after intravenous tabun administration.
Toxicology letters 2010;198(2):177-81.
2010: Christian Becker; Worek Franz; Harald John
Chromatographic analysis of toxic phosphylated oximes (POX): a brief overview.
Drug testing and analysis 2010;2(10):460-8.
2010: Timo Wille; Fredrik Ekström; Jong-Cheol Lee; Yuan-Ping Pang; Horst Thiermann; Worek Franz
Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds.
Biochemical pharmacology 2010;80(6):941-6.
2010: Florian Nachon; Eugenie Carletti; Worek Franz; Patrick Masson
Aging mechanism of butyrylcholinesterase inhibited by an N-methyl analogue of tabun: implications of the trigonal-bipyramidal transition state rearrangement for the phosphylation or reactivation of cholinesterases.
Chemico-biological interactions 2010;187(1-3):44-8.
2010: Nadine Aurbek; Nadja M Herkert; Marianne Koller; Horst Thiermann; Worek Franz
Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: is there a structure-activity relationship?
Chemico-biological interactions 2010;187(1-3):215-9.
2010: Horst Thiermann; Thomas Seeger; Sascha Gonder; Nadja Herkert; Bernd Antkowiak; Thomas Zilker; Florian Eyer; Worek Franz
Assessment of neuromuscular dysfunction during poisoning by organophosphorus compounds.
Chemico-biological interactions 2010;187(1-3):265-9.
2010: Worek Franz; Nadine Aurbek; Nadja M Herkert; Harald John; Michael Eddleston; Peter Eyer; Horst Thiermann
Evaluation of medical countermeasures against organophosphorus compounds: the value of experimental data and computer simulations.
Chemico-biological interactions 2010;187(1-3):259-64.
2010: Peter Eyer; Worek Franz; Horst Thiermann; Michael Eddleston
Paradox findings may challenge orthodox reasoning in acute organophosphate poisoning.
Chemico-biological interactions 2010;187(1-3):270-8.
2010: Horst Thiermann; Florian Eyer; Norbert Felgenhauer; Rudolf Pfab; Thomas Zilker; Peter Eyer; Worek Franz
Pharmacokinetics of obidoxime in patients poisoned with organophosphorus compounds.
Toxicology letters 2010;197(3):236-42.
2010: Horst Thiermann; Peter Eyer; Worek Franz
Muscle force and acetylcholinesterase activity in mouse hemidiaphragms exposed to paraoxon and treated by oximes in vitro.
Toxicology 2010;272(1-3):46-51.
2010: Oliver Tenberken; Horst Thiermann; Worek Franz; G Reiter
Chromatographic preparation and kinetic analysis of interactions between tabun enantiomers and acetylcholinesterase.
Toxicology letters 2010;195(2-3):142-6.
2010: Harald John; Michael Eddleston; R Eddie Clutton; Worek Franz; Horst Thiermann
Simultaneous quantification of the organophosphorus pesticides dimethoate and omethoate in porcine plasma and urine by LC-ESI-MS/MS and flow-injection-ESI-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(17-18):1234-45.
2010: Marianne Koller; Christian Becker; Horst Thiermann; Worek Franz
GC-MS and LC-MS analysis of nerve agents in body fluids: intra-laboratory verification test using spiked plasma and urine samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(17-18):1226-33.
2010: Oliver Tenberken; Worek Franz; Horst Thiermann; Georg Reiter
Development and validation of a sensitive gas chromatography-ammonia chemical ionization mass spectrometry method for the determination of tabun enantiomers in hemolysed blood and plasma of different species.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(17-18):1290-6.
2010: Nadja M Herkert; Nadine Aurbek; Peter Eyer; Horst Thiermann; Worek Franz
Comparative study of oxime-induced reactivation of erythrocyte and muscle AChE from different animal species following inhibition by sarin or paraoxon.
Toxicology letters 2010;194(3):94-101.
2010: T Wille; H Thiermann; Worek Franz
Development of a high-throughput screening for nerve agent detoxifying materials using a fully-automated robot-assisted biological assay.
Toxicology in vitro : an international journal published in association with BIBRA 2010;24(3):1026-31.
2010: Jürgen Kufleitner; Worek Franz; Jörg Kreuter
Incorporation of obidoxime into human serum albumin nanoparticles: optimisation of preparation parameters for the development of a stable formulation.
Journal of microencapsulation 2010;27(7):594-601.
2010: Jürgen Kufleitner; Sylvia Wagner; Worek Franz; Hagen von Briesen; Jörg Kreuter
Adsorption of obidoxime onto human serum albumin nanoparticles: drug loading, particle size and drug release.
Journal of microencapsulation 2010;27(6):506-13.
2009: Horst Thiermann; Thomas Zilker; Florian Eyer; Norbert Felgenhauer; Peter Eyer; Worek Franz
Monitoring of neuromuscular transmission in organophosphate pesticide-poisoned patients.
Toxicology letters 2009;191(2-3):297-304.
2009: T Wille; O Tenberken; G Reiter; S Müller; R Le Provost; O Lafont; F Estour; Horst Thiermann; Worek Franz
Detoxification of nerve agents by a substituted beta-cyclodextrin: application of a modified biological assay.
Toxicology 2009;265(3):96-100.
2009: Elisabet Artursson; Christine Akfur; Andreas Hörnberg; Worek Franz; Fredrik Ekström
Reactivation of tabun-hAChE investigated by structurally analogous oximes and mutagenesis.
Toxicology 2009;265(3):108-14.
2009: M Eddleston; Worek Franz; P Eyer; H Thiermann; L Von Meyer; K Jeganathan; M H R Sheriff; Andrew dawson; N A Buckley
Poisoning with the S-Alkyl organophosphorus insecticides profenofos and prothiofos.
QJM : monthly journal of the Association of Physicians 2009;102(11):785-92.
2009: Tracy Tazzeo; Worek Franz; Lj Janssen
The NADPH oxidase inhibitor diphenyleneiodonium is also a potent inhibitor of cholinesterases and the internal Ca(2+) pump.
British journal of pharmacology 2009;158(3):790-6.
2009: Horst Thiermann; Worek Franz; Peter Eyer; Florian Eyer; Norbert Felgenhauer; Thomas Zilker
Obidoxime in acute organophosphate poisoning: 2 - PK/PD relationships.
Clinical toxicology (Philadelphia, Pa.) 2009;47(8):807-13.
2009: Florian Eyer; Worek Franz; Peter Eyer; Norbert Felgenhauer; Mike Haberkorn; Thomas Zilker; Horst Thiermann
Obidoxime in acute organophosphate poisoning: 1 - clinical effectiveness.
Clinical toxicology (Philadelphia, Pa.) 2009;47(8):798-806.
2009: Florian Eyer; Darren M Roberts; Nicholas A Buckley; Michael Eddleston; Horst Thiermann; Worek Franz; Peter Eyer
Extreme variability in the formation of chlorpyrifos oxon (CPO) in patients poisoned by chlorpyrifos (CPF).
Biochemical pharmacology 2009;78(5):531-7.
2009: Eugénie Carletti; Nadine Aurbek; Emilie Gillon; Mélanie Loiodice; Yvain Nicolet; Juan C Fontecilla-Camps; Patrick Masson; Horst Thiermann; Florian Nachon; Worek Franz
Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun.
The Biochemical journal 2009;421(1):97-106.
2009: Michael Eddleston; Peter Eyer; Worek Franz; Edmund Juszczak; Nicola Alder; Fahim Mohamed; Lalith Senarathna; Ariyasena Hittarage; Shifa Azher; K Jeganathan; Shaluka Jayamanne; Ludwig von Meyer; Andrew dawson; M H Rezvi Sheriff; Nick A Buckley
Pralidoxime in acute organophosphorus insecticide poisoning--a randomised controlled trial.
PLoS medicine 2009;6(6):e1000104.
2009: Worek Franz; N M Herkert; Marianne Koller; Nadine Aurbek; Horst Thiermann
Interaction of pentylsarin analogues with human acetylcholinesterase: a kinetic study.
Toxicology letters 2009;187(2):119-23.
2009: Nadine Aurbek; Horst Thiermann; Florian Eyer; Peter Eyer; Worek Franz
Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis.
Toxicology 2009;259(3):133-9.
2009: Horst Theirmann; Worek Franz; Peter Eyer
Comments on "Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI 6".
Toxicology mechanisms and methods 2009;19(4):334; author reply 335.
2009: Nadja M Herkert; Guy Lallement; Didier Clarençon; Horst Thiermann; Worek Franz
Comparison of the oxime-induced reactivation of rhesus monkey, swine and guinea pig erythrocyte acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity.
Toxicology 2009;258(2-3):79-83.
2008: Peter Eyer; Michael Eddleston; Horst Thiermann; Worek Franz; Nick A Buckley
Are we using the right dose? - a tale of mole and gram.
British journal of clinical pharmacology 2008;66(4):451-2.
2008: Georg Reiter; John Mikler; Ira Hill; Kendal Weatherby; Horst Thiermann; Worek Franz
Chromatographic resolution, characterisation and quantification of VX enantiomers in hemolysed swine blood samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;873(1):86-94.
2008: Donald M Maxwell; Irwin Koplovitz; Worek Franz; Richard E Sweeney
A structure-activity analysis of the variation in oxime efficacy against nerve agents.
Toxicology and applied pharmacology 2008;231(2):157-64.
2008: Kai Kehe; K Raithel; Helmut Kreppel; M Jochum; Worek Franz; Horst Thiermann
Inhibition of poly(ADP-ribose) polymerase (PARP) influences the mode of sulfur mustard (SM)-induced cell death in HaCaT cells.
Archives of toxicology 2008;82(7):461-70.
2008: Michael Eddleston; P Eyer; Worek Franz; M H Rezvi Sheriff; N A Buckley
Predicting outcome using butyrylcholinesterase activity in organophosphorus pesticide self-poisoning.
QJM : monthly journal of the Association of Physicians 2008;101(6):467-74.
2008: Peter Eyer; Maria Radtke; Worek Franz
Reactions of isodimethoate with human red cell acetylcholinesterase.
Biochemical pharmacology 2008;75(10):2045-53.
2008: Marc-Michael Blum; Christopher M Timperley; Gareth R Williams; Horst Thiermann; Worek Franz
Inhibitory potency against human acetylcholinesterase and enzymatic hydrolysis of fluorogenic nerve agent mimics by human paraoxonase 1 and squid diisopropyl fluorophosphatase.
Biochemistry 2008;47(18):5216-24.
2008: Harald John; Worek Franz; Horst Thiermann
LC-MS-based procedures for monitoring of toxic organophosphorus compounds and verification of pesticide and nerve agent poisoning.
Analytical and bioanalytical chemistry 2008;391(1):97-116.
2008: Nadja M Herkert; Saskia Eckert; Peter Eyer; Rudolf Bumm; Georg Weber; Horst Thiermann; Worek Franz
Identical kinetics of human erythrocyte and muscle acetylcholinesterase with respect to carbamate pre-treatment, residual activity upon soman challenge and spontaneous reactivation after withdrawal of the inhibitors.
Toxicology 2008;246(2-3):188-92.
2008: Saskia Eckert; Peter Eyer; Marco Melzer; Horst Thiermann; Worek Franz
Effects of oximes on rate of decarbamylation of human red blood cell AChE measured with two different methods.
Biochemical pharmacology 2008;75(7):1561-6.
2008: Worek Franz; Nadine Aurbek; J Wetherell; P Pearce; T Mann; Horst Thiermann
Inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds: pig versus minipig acetylcholinesterase.
Toxicology 2008;244(1):35-41.
2008: Saskia Eckert; Peter Eyer; Nadja Herkert; Rudolf Bumm; Georg Weber; Horst Thiermann; Worek Franz
Comparison of the oxime-induced reactivation of erythrocyte and muscle acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity.
Biochemical pharmacology 2008;75(3):698-703.
2007: Georg Reiter; Marianne Koller; Horst Thiermann; Frédéric Dorandeu; John Mikler; Worek Franz
Development and application of procedures for the highly sensitive quantification of cyclosarin enantiomers in hemolysed swine blood samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;859(1):9-15.
2007: J Stenzel; Worek Franz; Peter Eyer
Preparation and characterization of dialkylphosphoryl-obidoxime conjugates, potent anticholinesterase derivatives that are quickly hydrolyzed by human paraoxonase (PON1192Q).
Biochemical pharmacology 2007;74(9):1390-400.
2007: Worek Franz; Nadine Aurbek; Horst Thiermann
Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI 6 in vitro.
Journal of applied toxicology : JAT 2007;27(6):582-8.
2007: Horst Thiermann; Kai Kehe; Dirk Steinritz; John Mikler; Ira Hill; Thomas Zilker; Peter Eyer; Worek Franz
Red blood cell acetylcholinesterase and plasma butyrylcholinesterase status: important indicators for the treatment of patients poisoned by organophosphorus compounds.
Arhiv za higijenu rada i toksikologiju 2007;58(3):359-66.
2007: Worek Franz; Nadine Aurbek; Marianne Koller; Christian Becker; Peter Eyer; Horst Thiermann
Kinetic analysis of reactivation and aging of human acetylcholinesterase inhibited by different phosphoramidates.
Biochemical pharmacology 2007;73(11):1807-17.
2007: G Becker; A Kawan; D Gutzeit; Worek Franz; Ladislaus Szinicz
Direct reaction of oximes with crotylsarin, cyclosarin, or VX in vitro.
Archives of toxicology 2007;81(6):415-20.
2007: Dirk Steinritz; J Emmler; M Hintz; Worek Franz; Helmut Kreppel; Ladislaus Szinicz; Kai Kehe
Apoptosis in sulfur mustard treated A549 cell cultures.
Life sciences 2007;80(24-25):2199-201.
2007: T Seeger; Worek Franz; Ladislaus Szinicz; Horst Thiermann
Reevaluation of indirect field stimulation technique to demonstrate oxime effectiveness in OP-poisoning in muscles in vitro.
Toxicology 2007;233(1-3):209-13.
2007: Horst Thiermann; Ladislaus Szinicz; Peter Eyer; Norbert Felgenhauer; Thomas Zilker; Worek Franz
Lessons to be learnt from organophosphorus pesticide poisoning for the treatment of nerve agent poisoning.
Toxicology 2007;233(1-3):145-54.
2007: Saskia Eckert; Peter Eyer; Worek Franz
Reversible inhibition of acetylcholinesterase by carbamates or huperzine A increases residual activity of the enzyme upon soman challenge.
Toxicology 2007;233(1-3):180-6.
2007: Frédéric Dorandeu; John Mikler; Horst Thiermann; Catherine Tenn; Corey Davidson; Thomas W Sawyer; Guy Lallement; Worek Franz
Swine models in the design of more effective medical countermeasures against organophosphorus poisoning.
Toxicology 2007;233(1-3):128-44.
2007: Peter Eyer; Ladislaus Szinicz; Horst Thiermann; Worek Franz; Thomas Zilker
Testing of antidotes for organophosphorus compounds: experimental procedures and clinical reality.
Toxicology 2007;233(1-3):108-19.
2007: Ladislaus Szinicz; Worek Franz; Horst Thiermann; Kai Kehe; Saskia Eckert; Peter Eyer
Development of antidotes: problems and strategies.
Toxicology 2007;233(1-3):23-30.
2007: A Bartling; Worek Franz; Ladislaus Szinicz; Horst Thiermann
Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase.
Toxicology 2007;233(1-3):166-72.
2007: Nadine Aurbek; Horst Thiermann; Ladislaus Szinicz; Worek Franz
Evaluation of HI 6 treatment after percutaneous VR exposure by use of a kinetic-based dynamic computer model.
Toxicology 2007;233(1-3):173-9.
2007: Worek Franz; Peter Eyer; Ladislaus Szinicz; Horst Thiermann
Simulation of cholinesterase status at different scenarios of nerve agent exposure.
Toxicology 2007;233(1-3):155-65.
2007: Worek Franz; Peter Eyer; Nadine Aurbek; Ladislaus Szinicz; Horst Thiermann
Recent advances in evaluation of oxime efficacy in nerve agent poisoning by in vitro analysis.
Toxicology and applied pharmacology 2007;219(2-3):226-34.
2006: Worek Franz; Peter Eyer
The liberation of thiocholine from acetylthiocholine (ASCh) by pralidoxime iodide (2=PAM) and other oximes (obidoxime and diacetylmonoxime).
Toxicology letters 2006;167(3):256-7; author reply 258.
2006: Michael Eddleston; Fahim Mohamed; James Davies; Peter Eyer; Worek Franz; M H Rezvi Sheriff; Nick A Buckley
Respiratory failure in acute organophosphorus pesticide self-poisoning.
QJM : monthly journal of the Association of Physicians 2006;99(8):513-22.
2006: Saskia Eckert; Peter Eyer; Harald Mückter; Worek Franz
Kinetic analysis of the protection afforded by reversible inhibitors against irreversible inhibition of acetylcholinesterase by highly toxic organophosphorus compounds.
Biochemical pharmacology 2006;72(3):344-57.
2006: Saskia Eckert; Peter Eyer; Harald Mückter; Worek Franz
Development of a dynamic model for real-time determination of membrane-bound acetylcholinesterase activity upon perfusion with inhibitors and reactivators.
Biochemical pharmacology 2006;72(3):358-65.
2006: Nadine Aurbek; Horst Thiermann; Ladislaus Szinicz; Peter Eyer; Worek Franz
Application of kinetic-based computer modelling to evaluate the efficacy of HI 6 in percutaneous VX poisoning.
Toxicology 2006;224(1-2):74-80.
2006: Nadine Aurbek; Horst Thiermann; Ladislaus Szinicz; Peter Eyer; Worek Franz
Analysis of inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds with human and pig acetylcholinesterase.
Toxicology 2006;224(1-2):91-9.
2005: Worek Franz; Ladislaus Szinicz; Horst Thiermann
Estimation of oxime efficacy in nerve agent poisoning: a kinetic approach.
Chemico-biological interactions 2005;157-158():349-52.
2005: Horst Thiermann; Ladislaus Szinicz; Peter Eyer; Thomas Zilker; Worek Franz
Correlation between red blood cell acetylcholinesterase activity and neuromuscular transmission in organophosphate poisoning.
Chemico-biological interactions 2005;157-158():345-7.
2005: Worek Franz; Ladislaus Szinicz; Peter Eyer; Horst Thiermann
Evaluation of oxime efficacy in nerve agent poisoning: development of a kinetic-based dynamic model.
Toxicology and applied pharmacology 2005;209(3):193-202.
2005: A Bartling; Horst Thiermann; Ladislaus Szinicz; Worek Franz
Effect of metoclopramide and ranitidine on the inhibition of human AChE by VX in vitro.
Journal of applied toxicology : JAT 2005;25(6):568-71.
2005: Worek Franz; Marianne Koller; Horst Thiermann; Ladislaus Szinicz
Diagnostic aspects of organophosphate poisoning.
Toxicology 2005;214(3):182-9.
2005: Horst Thiermann; Peter Eyer; Worek Franz; Ladislaus Szinicz
Effects of oximes on muscle force and acetylcholinesterase activity in isolated mouse hemidiaphragms exposed to paraoxon.
Toxicology 2005;214(3):190-7.
2005: Michael Eddleston; Peter Eyer; Worek Franz; Fahim Mohamed; Lalith Senarathna; Ludwig von Meyer; Edmund Juszczak; Ariyasena Hittarage; Shifa Azhar; Wasantha Dissanayake; M H Rezvi Sheriff; Ladislaus Szinicz; Andrew dawson; Nick A Buckley
Differences between organophosphorus insecticides in human self-poisoning: a prospective cohort study.
Lancet 2005;366(9495):1452-9.
2005: Daniela Kiderlen; Peter Eyer; Worek Franz
Formation and disposition of diethylphosphoryl-obidoxime, a potent anticholinesterase that is hydrolyzed by human paraoxonase (PON1).
Biochemical pharmacology 2005;69(12):1853-67.
2004: Worek Franz; Horst Thiermann; Ladislaus Szinicz; Peter Eyer
Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes.
Biochemical pharmacology 2004;68(11):2237-48.
2004: S Herkenhoff; Ladislaus Szinicz; Vipin K Rastogi; Tu-Chen Cheng; Joseph J DeFrank; Worek Franz
Effect of organophosphorus hydrolysing enzymes on obidoxime-induced reactivation of organophosphate-inhibited human acetylcholinesterase.
Archives of toxicology 2004;78(6):338-43.
2004: Worek Franz; Horst Thiermann; Ladislaus Szinicz
Reactivation and aging kinetics of human acetylcholinesterase inhibited by organophosphonylcholines.
Archives of toxicology 2004;78(4):212-7.
2003: Peter Eyer; Worek Franz; Daniela Kiderlen; Dr Goran Sinko; Anita Stuglin; Vera Simeon-Rudolf; Elsa Reiner
Molar absorption coefficients for the reduced Ellman reagent: reassessment.
Analytical biochemistry 2003;312(2):224-7.
2003: Florian Eyer; Veronika Meischner; Daniela Kiderlen; Horst Thiermann; Worek Franz; Michael Haberkorn; Norbert Felgenhauer; Thomas Zilker; Peter Eyer
Human parathion poisoning. A toxicokinetic analysis.
Toxicological reviews 2003;22(3):143-63.
2002: S Krummer; Horst Thiermann; Worek Franz; Peter Eyer
Equipotent cholinesterase reactivation in vitro by the nerve agent antidotes HI 6 dichloride and HI 6 dimethanesulfonate.
Archives of toxicology 2002;76(10):589-95.
2002: Worek Franz; G Reiter; Peter Eyer; Ladislaus Szinicz
Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates.
Archives of toxicology 2002;76(9):523-9.
2000: Daniela Kiderlen; Worek Franz; R Klimmek; Peter Eyer
The phosphoryl oxime-destroying activity of human plasma.
Archives of toxicology 2000;74(1):27-32.
2000: Worek Franz; Peter Eyer; Daniela Kiderlen; Horst Thiermann; Ladislaus Szinicz
Effect of human plasma on the reactivation of sarin-inhibited human erythrocyte acetylcholinesterase.
Archives of toxicology 2000;74(1):21-6.
2000: Norbert Felgenhauer; Thomas Zilker; Worek Franz; Peter Eyer
Intoxication with huperzine A, a potent anticholinesterase found in the fir club moss.
Journal of toxicology. Clinical toxicology 2000;38(7):803-8.
1999: Worek Franz; U Mast; Daniela Kiderlen; C Diepold; Peter Eyer
Improved determination of acetylcholinesterase activity in human whole blood.
Clinica chimica acta; international journal of clinical chemistry 1999;288(1-2):73-90.
1999: Horst Thiermann; Ladislaus Szinicz; Florian Eyer; Worek Franz; Peter Eyer; Norbert Felgenhauer; Thomas Zilker
Modern strategies in therapy of organophosphate poisoning.
Toxicology letters 1999;107(1-3):233-9.
1999: Worek Franz; C Diepold; Peter Eyer
Dimethylphosphoryl-inhibited human cholinesterases: inhibition, reactivation, and aging kinetics.
Archives of toxicology 1999;73(1):7-14.
1998: Worek Franz; Peter Eyer; Ladislaus Szinicz
Inhibition, reactivation and aging kinetics of cyclohexylmethylphosphonofluoridate-inhibited human cholinesterases.
Archives of toxicology 1998;72(9):580-7.
1998: Worek Franz; R Widmann; O Knopff; Ladislaus Szinicz
Reactivating potency of obidoxime, pralidoxime, HI 6 and HLö 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds.
Archives of toxicology 1998;72(4):237-43.
1997: Worek Franz; M Bäcker; Horst Thiermann; Ladislaus Szinicz; U Mast; R Klimmek; Peter Eyer
Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning.
Human & experimental toxicology 1997;16(8):466-72.
1997: Thomas Zilker; Norbert Felgenhauer; A Hibler; Rudolf Pfab; Horst Thiermann; Worek Franz; Peter Eyer
Factors influencing the efficacy of obidoxime in organophosphate pesticides poisoning.
Przegla̧d lekarski 1997;54(10):662-4.
1996: Worek Franz; T Kirchner; M Bäcker; Ladislaus Szinicz
Reactivation by various oximes of human erythrocyte acetylcholinesterase inhibited by different organophosphorus compounds.
Archives of toxicology 1996;70(8):497-503.
1995: Worek Franz; A Kleine; Ladislaus Szinicz
Effect of pyridostigmine pretreatment on cardiorespiratory function in tabun poisoning.
Human & experimental toxicology 1995;14(8):634-42.
1995: Worek Franz; A Kleine; K Falke; Ladislaus Szinicz
Arrhythmias in organophosphate poisoning: effect of atropine and bispyridinium oximes.
Archives internationales de pharmacodynamie et de thérapie 1995;329(3):418-35.
1995: Worek Franz; R Klimmek; Ladislaus Szinicz
Effects of atropine and soman on the pharmacokinetics of the oxime HLö 7 dimethanesulfonate in anesthetized guinea-pigs.
Drug and chemical toxicology 1995;18(2-3):137-49.
1995: Worek Franz; T Kirchner; Ladislaus Szinicz
Effect of atropine and bispyridinium oximes on respiratory and circulatory function in guinea-pigs poisoned by sarin.
Toxicology 1995;95(1-3):123-33.
1995: Worek Franz; Ladislaus Szinicz
Cardiorespiratory function in nerve agent poisoned and oxime + atropine treated guinea-pigs: effect of pyridostigmine pretreatment.
Archives of toxicology 1995;69(5):322-9.
1994: Worek Franz; T Kirchner; Ladislaus Szinicz
Effect of atropine, HLö 7 and HI 6 on respiratory and circulatory function in guinea-pigs poisoned by O-ethyl S-[2-(diisopropylamino) ethyl] methylphosponothioate (VX).
Pharmacology & toxicology 1994;75(5):302-9.
1994: Worek Franz; T Kirchner; Ladislaus Szinicz
Treatment of tabun poisoned guinea-pigs with atropine, HLö 7 or HI 6: effect on respiratory and circulatory function.
Archives of toxicology 1994;68(4):231-9.
1993: Worek Franz; Ladislaus Szinicz
Analysis of cardiovascular and respiratory effects of various doses of soman in guinea-pigs: efficacy of atropine treatment.
Archives internationales de pharmacodynamie et de thérapie 1993;325():96-112.
1993: Worek Franz; Ladislaus Szinicz
Investigation of acute cardiovascular and respiratory toxicity of HLö 7 dimethanesulfonate and HI 6 dichloride in anaesthetized guinea-pigs.
Pharmacology & toxicology 1993;73(2):91-5.
1993: Worek Franz; Ladislaus Szinicz
Atropine and oxime treatment in lethal soman poisoning of anaesthetized guinea-pigs: HLö 7 dimethanesulfonate versus HI 6 dichloride.
Pharmacology & toxicology 1993;72(1):13-21.
1992: Peter Eyer; I Hagedorn; R Klimmek; P Lippstreu; M Löffler; H Oldiges; U Spöhrer; I Steidl; Ladislaus Szinicz; Worek Franz
HLö 7 dimethanesulfonate, a potent bispyridinium-dioxime against anticholinesterases.
Archives of toxicology 1992;66(9):603-21.
1989: R Neumann; Worek Franz; G Blümel; G J Zimmermann; H L Fehm; U J Pfeiffer
Cortisol deficiency in metomidate anesthetized bacteremic pigs: results in circulatory failure--beneficial effect of cortisol substitution.
Acta anaesthesiologica Scandinavica 1989;33(5):379-84.
1988: Worek Franz; G Blümel; J Zeravik; G J Zimmermann; U J Pfeiffer
Comparison of ketamine and pentobarbital anesthesia with the conscious state in a porcine model of Pseudomonas aeruginosa septicemia.
Acta anaesthesiologica Scandinavica 1988;32(7):509-15.