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Jason Moffat

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TOP 3
Traver Hart; Jason Moffat
Scaling up the systematic hunt for mammalian genetic interactions.
Greg M Findlay; Gerald Gish; Marilyn S Hsiung; Haiming Huang; Mitsuhiko Ikura; Tomonori Kaneko; Troy Ketela; Fredrik Lanner; Shawn S-C Li; Jason Moffat; Evangelia Petsalaki; Janet Rossant; Sachdev S Sidhu; Matthew J Smith; Lorne Taylor; Monika Tucholska; Richard D Bagshaw; David D Bowtell; Katie Cockburn; Tony Pawson
Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.
Anthony B Mak; Ralph Mazitschek; Ginny I Chen; Jasna Curak; Anne-Claude Gingras; Saranya Kittanakom; Benjamin G Neel; Allison M L Nixon; Igor Stagljar; Jocelyn M Stewart; Jason Moffat
Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiation.

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All Publications

2013: Traver Hart; Jason Moffat
Scaling up the systematic hunt for mammalian genetic interactions.
Nature methods 2013;10(5):397-9.
2013: Greg M Findlay; Gerald Gish; Marilyn S Hsiung; Haiming Huang; Mitsuhiko Ikura; Tomonori Kaneko; Troy Ketela; Fredrik Lanner; Shawn S-C Li; Jason Moffat; Evangelia Petsalaki; Janet Rossant; Sachdev S Sidhu; Matthew J Smith; Lorne Taylor; Monika Tucholska; Richard D Bagshaw; David D Bowtell; Katie Cockburn; Tony Pawson
Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.
Cell 2013;152(5):1008-20.
2012: Anthony B Mak; Ralph Mazitschek; Ginny I Chen; Jasna Curak; Anne-Claude Gingras; Saranya Kittanakom; Benjamin G Neel; Allison M L Nixon; Igor Stagljar; Jocelyn M Stewart; Jason Moffat
Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiation.
Cell reports 2012;2(4):951-63.
2012: Johnny M Tkach; Askar Yimit; Charles Boone; Michael Costanzo; Trisha N Davis; Jason A Hendry; Daniel Jaschob; Anna Y Lee; Jason Moffat; Corey Nislow; Jiongwen Ou; Michael Riffle; Grant W Brown
Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.
Nature cell biology 2012;14(9):966-76.
2012: Anthony B Mak; Jason Moffat
A versatile lentiviral expression system to identify mammalian protein-protein interactions.
Methods (San Diego, Calif.) 2012;57(4):409-16.
2012: Michael D Eastwood; Kwan Yin Lee; Sally W T Cheung; Jason Moffat; Marc D Meneghini
Developmentally programmed nuclear destruction during yeast gametogenesis.
Developmental cell 2012;23(1):35-44.
2012: Craig D Simpson; Yanina Eberhard; Rose Hurren; Dahlia Kasimer; Troy Ketela; Neil MacLean; Jason Moffat; Aaron D Schimmer
A genome wide shRNA screen identifies α/β hydrolase domain containing 4 (ABHD4) as a novel regulator of anoikis resistance.
Apoptosis : an international journal on programmed cell death 2012;17(7):666-78.
2012: Anthony B Mak; Allison M L Nixon; Jason Moffat
The mixed lineage leukemia (MLL) fusion-associated gene AF4 promotes CD133 transcription.
Cancer research 2012;72(8):1929-34.
2012: Richard Marcotte; Mauricio Medrano; Patricia Mero; Christine Misquitta; Glauber C Brito; Kevin R Brown; Alla Buzina; Alessandro Datti; Bohdana Fedyshyn; Yaroslav Fedyshyn; Maliha Haider; Konstantina Karamboulas; Dahlia Kasimer; Troy Ketela; Judice L Y Koh; Paul M Krzyzanowski; Marianna Luhova; Benjamin G Neel; Josee Normand; Robert Rottapel; Azin Sayad; Fabrice Sircoulomb; Fernando Suarez; Dewald van Dyk; Franco J Vizeacoumar; Frederick S Vizeacoumar; Jeffrey L Wrana; Jason Moffat
Essential gene profiles in breast, pancreatic, and ovarian cancer cells.
Cancer discovery 2012;2(2):172-89.
2012: Saravanan Rajan; Harry Zuzan; Huan Chu Pham Dang; Haig Djambazian; Yaroslav Fedyshyn; Thomas J Hudson; Troy Ketela; Jason Moffat; Robert Sladek
Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation.
Physiological genomics 2012;44(2):183-97.
2012: Reza Beheshti Zavareh; Marcela Gronda; Rose Hurren; Troy Ketela; Neil Maclean; Jason Moffat; David R Rose; Harry Schachter; Aaron D Schimmer; Craig D Simpson; Mahadeo A Sukhai; Carol J Swallow; Xiaoming Wang; Francis Zih; James W Dennis
Suppression of cancer progression by MGAT1 shRNA knockdown.
PloS one 2012;7(9):e43721.
2011: Anthony B Mak; Kim M Blakely; Dahlia Kasimer; Troy Ketela; Khan T Osman; Pier-Andrée Penttilä; Andrey I Shukalyuk; Rashida A Williams; Jason Moffat
CD133 protein N-glycosylation processing contributes to cell surface recognition of the primitive cell marker AC133 epitope.
The Journal of biological chemistry 2011;286(47):41046-56.
2011: Marko Skrtić; Paul Spagnuolo; Shrivani Sriskanthadevan; Jean C Y Wang; Xiaoming Wang; Zezhou Wang; Jeffery Wrana; Justyna Bartoszko; Jessie H Cameron; Alessandro Datti; John E Dick; Connie J Eaves; Yanina Eberhard; Marinella Gebbia; Guri Giaever; Marcela Gronda; Keith Humphries; Rose Hurren; Bozhena Jhas; Yulia Jitkova; Troy Ketela; Courteney K Lai; Neil Maclean; Mark D Minden; Jason Moffat; Corey Nislow; Brian H Robinson; Angela C Rutledge; Aaron D Schimmer
Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia.
Cancer cell 2011;20(5):674-88.
2011: Hong Han; Jason Moffat; Razvan Nutiu; Benjamin J Blencowe
SnapShot: High-throughput sequencing applications.
Cell 2011;146(6):1044, 1044.e1-2.
2011: Yanina Eberhard; Marcela Gronda; Rose Hurren; Alessandro Datti; Neil MacLean; Troy Ketela; Jason Moffat; Jeffrey L Wrana; Aaron D Schimmer
Inhibition of SREBP1 sensitizes cells to death ligands.
Oncotarget 2011;2(3):186-96.
2011: Kim Blakely; Troy Ketela; Jason Moffat
Pooled lentiviral shRNA screening for functional genomics in mammalian cells.
Methods in molecular biology (Clifton, N.J.) 2011;781():161-82.
2011: Troy Ketela; Judice L Y Koh; Jason Moffat; David E Root; Andrew M Smith; Anuradha Surendra; Xiaoping Yang; Ron Ammar; Anthony Arnoldo; Kim Blakely; Kevin R Brown; Kahlin Cheung-Ong; Glenn S Cowley; Tanja Durbic; Elke Ericson; Guri Giaever; Shuba Gopal; Jennifer K Grenier; Lawrence E Heisler; Dina Karamboulas; Dahlia Kasimer; Corey Nislow
A comprehensive platform for highly multiplexed mammalian functional genetic screens.
BMC genomics 2011;12():213.
2010: Jacky Chung; Joanne Lau; Lynn S Cheng; R Ian Grant; Fiona Robinson; Troy Ketela; Patricia P Reis; olga roche; Suzanne Kamel-Reid; Jason Moffat; Michael Ohh; Bayardo Perez-Ordonez; David R Kaplan; Meredith S Irwin
SATB2 augments ΔNp63α in head and neck squamous cell carcinoma.
EMBO reports 2010;11(10):777-83.
2010: Olena Morozova; Milijana Vojvodic; Natalie Grinshtein; Loen M Hansford; Kim M Blakely; Alexandra Maslova; Martin Hirst; Timothee Cezard; Ryan D Morin; Richard Moore; Kristen M Smith; Freda Miller; Paul Taylor; Nina Thiessen; Richard Varhol; Yongjun Zhao; Steven Jones; Jason Moffat; Thomas Kislinger; Michael F Moran; David R Kaplan; Marco A Marra
System-level analysis of neuroblastoma tumor-initiating cells implicates AURKB as a novel drug target for neuroblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(18):4572-82.
2010: Kristen M Smith; Alessandro Datti; Mayumi Fujitani; Natalie Grinshtein; Libo Zhang; Olena Morozova; Kim M Blakely; Susan A Rotenberg; Loen M Hansford; Freda D Miller; Herman Yeger; Meredith S Irwin; Jason Moffat; Marco A Marra; Sylvain Baruchel; Jeffrey L Wrana; David R Kaplan
Selective targeting of neuroblastoma tumour-initiating cells by compounds identified in stem cell-based small molecule screens.
EMBO molecular medicine 2010;2(9):371-84.
2010: Anthony B Mak; Zuyao Ni; Johannes A Hewel; Ginny I Chen; Guoqing Zhong; Konstantina Karamboulas; Kim Blakely; Sandra Smiley; Edyta Marcon; Denitza Roudeva; Joyce Li; Jonathan B Olsen; Cuihong Wan; Thanuja Punna; Ruth Isserlin; Sergei Chetyrkin; Anne-Claude Gingras; Andrew Emili; Jack Greenblatt; Jason Moffat
A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency.
Molecular & cellular proteomics : MCP 2010;9(5):811-23.
2010: G Wei Xu; Mohsin Ali; Tabitha E Wood; Derek Wong; Neil Maclean; Xiaoming Wang; Marcela Gronda; Marko Skrtic; Xiaoming Li; Rose Hurren; Xinliang Mao; Meenakshi Venkatesan; Reza Beheshti Zavareh; Troy Ketela; John C Reed; David Rose; Jason Moffat; Robert A Batey; Sirano Dhe-Paganon; Aaron D Schimmer
The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma.
Blood 2010;115(11):2251-9.
2010: Tabitha E Wood; Shadi Dalili; Craig D Simpson; Mahadeo A Sukhai; Rose Hurren; Kika Anyiwe; Xinliang Mao; Fernando Suarez Saiz; Marcela Gronda; Yanina Eberhard; Neil MacLean; Troy Ketela; John C Reed; Jason Moffat; Mark D Minden; Robert A Batey; Aaron D Schimmer
Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands.
Molecular cancer therapeutics 2010;9(1):246-56.
2009: Dongqing Huang; Supipi Kaluarachchi; Dewald van Dyk; Helena Friesen; Richelle Sopko; Wei Ye; Nazareth Bastajian; Jason Moffat; Holly Sassi; Michael Costanzo; Brenda J Andrews
Dual regulation by pairs of cyclin-dependent protein kinases and histone deacetylases controls G1 transcription in budding yeast.
PLoS biology 2009;7(9):e1000188.
2009: Alicia M Viloria-Petit; Laurent David; Jun Yong Jia; Tuba Erdemir; Anita L Bane; Dushanthi Pinnaduwage; Luba Roncari; Masahiro Narimatsu; Rohit Bose; Jason Moffat; John Wong; Robert S Kerbel; Frances P O'Malley; Irene L Andrulis; Jeffrey L Wrana
A role for the TGFbeta-Par6 polarity pathway in breast cancer progression.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(33):14028-33.
2009: Thouis Jones; Anne E Carpenter; Michael R Lamprecht; Jason Moffat; Serena J Silver; Jennifer K Grenier; Adam B Castoreno; Ulrike S Eggert; David E Root; Polina Golland; David M Sabatini
Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(6):1826-31.
2007: Jason Moffat; Jan H Reiling; David M Sabatini
Off-target effects associated with long dsRNAs in Drosophila RNAi screens.
Trends in pharmacological sciences 2007;28(4):149-51.
2006: David A Guertin; Deanna M Stevens; Carson C Thoreen; Aurora A Burds; Nada Y Kalaany; Jason Moffat; Michael Brown; Kevin J Fitzgerald; David M Sabatini
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.
Developmental cell 2006;11(6):859-71.
2006: Jason Moffat; Dorre A Grueneberg; Xiaoping Yang; So Young Kim; Angela M Kloepfer; Gregory Hinkle; Bruno Piqani; Thomas M Eisenhaure; Biao Luo; Jennifer K Grenier; Anne E Carpenter; Shi Yin Foo; Sheila A Stewart; Brent R Stockwell; Nir Hacohen; William C Hahn; Eric S Lander; David M Sabatini; David E Root
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.
Cell 2006;124(6):1283-98.
2006: Jason Moffat; David M Sabatini
Building mammalian signalling pathways with RNAi screens.
Nature reviews. Molecular cell biology 2006;7(3):177-87.
2006: Anne E Carpenter; Thouis Jones; Michael R Lamprecht; Colin Clarke; In Han Kang; Ola Friman; David A Guertin; Joo Han Chang; Robert A Lindquist; Jason Moffat; Polina Golland; David M Sabatini
CellProfiler: image analysis software for identifying and quantifying cell phenotypes.
Genome biology 2006;7(10):R100.
2004: Sanie Mnaimneh; Armaity P Davierwala; Jennifer Haynes; Jason Moffat; Wen-Tao Peng; Wen Zhang; Xueqi Yang; Jeff Pootoolal; Gordon Chua; Andres Lopez; Miles Trochesset; Darcy Morse; Nevan J Krogan; Shawna L Hiley; Zhijian Li; Quaid Morris; Jörg Grigull; Nicholas Mitsakakis; Christopher J Roberts; Jack F Greenblatt; Charles Boone; Chris A Kaiser; Brenda J Andrews; Timothy R Hughes
Exploration of essential gene functions via titratable promoter alleles.
Cell 2004;118(1):31-44.
2004: Jason Moffat; Brenda Andrews
Late-G1 cyclin-CDK activity is essential for control of cell morphogenesis in budding yeast.
Nature cell biology 2004;6(1):59-66.
2003: Jason Moffat; Brenda Andrews
Ac'septin' a signal: kinase regulation by septins.
Developmental cell 2003;5(4):528-30.
2002: Dongqing Huang; Jason Moffat; Brenda Andrews
Dissection of a complex phenotype by functional genomics reveals roles for the yeast cyclin-dependent protein kinase Pho85 in stress adaptation and cell integrity.
Molecular and cellular biology 2002;22(14):5076-88.
2001: HJ McBride; Alok Kumar Sil; Vivien Measday; Yaxin Yu; Jason Moffat; M E Maxon; I Herskowitz; Brenda Andrews; David J Stillman
The protein kinase Pho85 is required for asymmetric accumulation of the Ash1 protein in Saccharomyces cerevisiae.
Molecular microbiology 2001;42(2):345-53.
2001: Kristin Baetz; Jason Moffat; Jennifer Haynes; M Chang; Brenda Andrews
Transcriptional coregulation by the cell integrity mitogen-activated protein kinase Slt2 and the cell cycle regulator Swi4.
Molecular and cellular biology 2001;21(19):6515-28.
2000: Vivien Measday; HJ McBride; Jason Moffat; David J Stillman; Brenda Andrews
Interactions between Pho85 cyclin-dependent kinase complexes and the Swi5 transcription factor in budding yeast.
Molecular microbiology 2000;35(4):825-34.
2000: Jason Moffat; D Huang; B Andrews
Functions of Pho85 cyclin-dependent kinases in budding yeast.
Progress in cell cycle research 2000;4():97-106.
1999: D Huang; G Patrick; Jason Moffat; Li-Huei Tsai; Brenda Andrews
Mammalian Cdk5 is a functional homologue of the budding yeast Pho85 cyclin-dependent protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(25):14445-50.
1998: D Huang; Jason Moffat; Wayne A Wilson; L Moore; C Cheng; Peter J Roach; B Andrews
Cyclin partners determine Pho85 protein kinase substrate specificity in vitro and in vivo: control of glycogen biosynthesis by Pcl8 and Pcl10.
Molecular and cellular biology 1998;18(6):3289-99.
1998: G Huyer; J Kelly; Jason Moffat; Robert Zamboni; Z Jia; Michael J Gresser; Chidambaram Ramachandran
Affinity selection from peptide libraries to determine substrate specificity of protein tyrosine phosphatases.
Analytical biochemistry 1998;258(1):19-30.
1998: B P Kennedy; claudio soravia; Jason Moffat; L Xia; T Hiruki; S Collins; Steven Gallinger; Bharati Bapat
Overexpression of the nonpancreatic secretory group II PLA2 messenger RNA and protein in colorectal adenomas from familial adenomatous polyposis patients.
Cancer research 1998;58(3):500-3.