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Kui Shen

Research Profile

Chemicals & Drugs

Physiology

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Amino Acid Sequences

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Publications

TOP 3
Yunpeng Bai; Youjia Cao; Yuanshu Dong; Sijiu Liu; Yong Luo; Lawrence A Quilliam; Kui Shen; Chad D Walls; Clark D Wells; Lujuan Zhang; Zhong-Yin Zhang
PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein.
Kui Shen; Lixin Qi; Lynn Stiff
Peptidomimetic competitive inhibitors of protein tyrosine phosphatases.
Kui Shen; Lixin Qi; Mohini Ravula; Krzysztof Klimaszewski
Synthesis and peptide incorporation of an unnatural amino acid containing activity-based probe for protein tyrosine phosphatases.

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All Publications

2011: Yunpeng Bai; Youjia Cao; Yuanshu Dong; Sijiu Liu; Yong Luo; Lawrence A Quilliam; Kui Shen; Chad D Walls; Clark D Wells; Lujuan Zhang; Zhong-Yin Zhang
PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein.
The Journal of biological chemistry 2011;286(49):42316-24.
2010: Kui Shen; Lixin Qi; Lynn Stiff
Peptidomimetic competitive inhibitors of protein tyrosine phosphatases.
Current pharmaceutical design 2010;16(28):3101-17.
2009: Kui Shen; Lixin Qi; Mohini Ravula; Krzysztof Klimaszewski
Synthesis and peptide incorporation of an unnatural amino acid containing activity-based probe for protein tyrosine phosphatases.
Bioorganic & medicinal chemistry letters 2009;19(12):3264-7.
2007: Kui Shen
Analyzing protein tyrosine phosphatases by phosphotyrosine analog integration.
Methods (San Diego, Calif.) 2007;42(3):234-42.
2006: Robert Cheng; Martin E M Noble; Vicky Skamnaki; Nick R Brown; Edward D Lowe; Luke Kontogiannis; Kui Shen; Philip A Cole; Giuliano Siligardi; Louise N Johnson
The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition.
The Journal of biological chemistry 2006;281(32):23167-79.
2006: Xuewu Zhang; Jodi Gureasko; Kui Shen; Philip A Cole; John Kuriyan
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor.
Cell 2006;125(6):1137-49.
2006: Nicholas M Levinson; Olga Kuchment; Kui Shen; Matthew Adam Young; Michael Koldobskiy; Martin Karplus; Philip A Cole; John Kuriyan
A Src-like inactive conformation in the abl tyrosine kinase domain.
PLoS biology 2006;4(5):e144.
2005: Kui Shen; Aliya C Hines; Dirk Schwarzer; KERRY PAUMI; Philip A Cole
Protein kinase structure and function analysis with chemical tools.
Biochimica et biophysica acta 2005;1754(1-2):65-78.
2003: Kui Shen; Philip A Cole
Conversion of a tyrosine kinase protein substrate to a high affinity ligand by ATP linkage.
Journal of the American Chemical Society 2003;125(52):16172-3.
2003: Laiping Xie; Seung-Yub Lee; jannik andersen; Steve Waters; Kui Shen; Xiao-Ling Guo; Niels Peter H Moller; Jerrold M Olefsky; David S Lawrence; Zhong-Yin Zhang
Cellular effects of small molecule PTP1B inhibitors on insulin signaling.
Biochemistry 2003;42(44):12792-804.
2003: Philip A Cole; Kui Shen; Yingfeng Qiao; Dongxia Wang
Protein tyrosine kinases Src and Csk: a tail's tale.
Current opinion in chemical biology 2003;7(5):580-5.
2003: Philip A Cole; Aliya D Courtney; Kui Shen; Zhongsen Zhang; Yingfeng Qiao; Wei Lu; Daniel M Williams
Chemical approaches to reversible protein phosphorylation.
Accounts of chemical research 2003;36(6):444-52.
2003: Wei Lu; Kui Shen; Philip A Cole
Chemical dissection of the effects of tyrosine phosphorylation of SHP-2.
Biochemistry 2003;42(18):5461-8.
2003: Jin-Peng Sun; Alexander A Fedorov; Seung-Yub Lee; Xiao-Ling Guo; Kui Shen; David S Lawrence; Steven C Almo; Zhong-Yin Zhang
Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor.
The Journal of biological chemistry 2003;278(14):12406-14.
2003: Zhongsen Zhang; Kui Shen; Wei Lu; Philip A Cole
The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation.
The Journal of biological chemistry 2003;278(7):4668-74.
2002: Xiao-Ling Guo; Kui Shen; Fang Wang; David S Lawrence; Zhong-Yin Zhang
Probing the molecular basis for potent and selective protein-tyrosine phosphatase 1B inhibition.
The Journal of biological chemistry 2002;277(43):41014-22.
2001: Kui Shen; YF Keng; Li Wu; X L Guo; David S Lawrence; Zhong-Yin Zhang
Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure.
The Journal of biological chemistry 2001;276(50):47311-9.
2001: Bo Zhou; Li Wu; Kui Shen; J Zhang; David S Lawrence; Zhong-Yin Zhang
Multiple regions of MAP kinase phosphatase 3 are involved in its recognition and activation by ERK2.
The Journal of biological chemistry 2001;276(9):6506-15.
1999: M Taing; YF Keng; Kui Shen; Li Wu; David S Lawrence; Zhong-Yin Zhang
Potent and highly selective inhibitors of the protein tyrosine phosphatase 1B.
Biochemistry 1999;38(12):3793-803.