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tong cao

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Xin Fu; Mingming Li; Hua Liu; Kai Lu; Wei Seong Toh; tong cao
Establishment of clinically compliant human embryonic stem cells in an autologous feeder-free system.
Wei Seong Toh; Eng Hin Lee; Xi-Min Guo; Jerry K Y Chan; Chen Hua Yeow; Andre B H Choo; tong cao
Cartilage repair using hyaluronan hydrogel-encapsulated human embryonic stem cell-derived chondrogenic cells.
Xin Fu; Wei Seong Toh; Hua Liu; Kai Lu; Mingming Li; M Prakash Hande; tong cao
Autologous feeder cells from embryoid body outgrowth support the long-term growth of human embryonic stem cells more effectively than those from direct differentiation.

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All Publications

2011: Xin Fu; Mingming Li; Hua Liu; Kai Lu; Wei Seong Toh; tong cao
Establishment of clinically compliant human embryonic stem cells in an autologous feeder-free system.
Tissue engineering. Part C, Methods 2011;17(9):927-37.
2010: Wei Seong Toh; Eng Hin Lee; Xi-Min Guo; Jerry K Y Chan; Chen Hua Yeow; Andre B H Choo; tong cao
Cartilage repair using hyaluronan hydrogel-encapsulated human embryonic stem cell-derived chondrogenic cells.
Biomaterials 2010;31(27):6968-80.
2010: Xin Fu; Wei Seong Toh; Hua Liu; Kai Lu; Mingming Li; M Prakash Hande; tong cao
Autologous feeder cells from embryoid body outgrowth support the long-term growth of human embryonic stem cells more effectively than those from direct differentiation.
Tissue engineering. Part C, Methods 2010;16(4):719-33.
2010: Abdul Jalil Rufaihah; Husnain Khawaja Haider; Boon Chin Heng; Lei Ye; Ru San Tan; Wei Seong Toh; Xian Feng Tian; Eugene Kwang-Wei Sim; tong cao
Therapeutic angiogenesis by transplantation of human embryonic stem cell-derived CD133+ endothelial progenitor cells for cardiac repair.
Regenerative medicine 2010;5(2):231-44.
2010: Wei Seong Toh; Eng Hin Lee; Mark Richards; tong cao
In vitro derivation of chondrogenic cells from human embryonic stem cells.
Methods in molecular biology (Clifton, N.J.) 2010;584():317-31.
2009: Wei Seong Toh; Xi-Min Guo; Andre B Choo; Kai Lu; Eng Hin Lee; tong cao
Differentiation and enrichment of expandable chondrogenic cells from human embryonic stem cells in vitro.
Journal of cellular and molecular medicine 2009;13(9B):3570-90.
2009: Saji George; Boon Chin Heng; Kumar Jayaseelan Vinoth; Anil kishen; tong cao
Comparison of the response of human embryonic stem cells and their differentiated progenies to oxidative stress.
Photomedicine and laser surgery 2009;27(4):669-74.
2009: Hua Liu; Wei Seong Toh; Kai Lu; Paul Anthony MacAry; David Michael Kemeny; tong cao
A subpopulation of mesenchymal stromal cells with high osteogenic potential.
Journal of cellular and molecular medicine 2009;13(8B):2436-47.
2009: Zheng Yang; Lin Sui; Wei Seong Toh; Eng Hin Lee; tong cao
Stage-dependent effect of TGF-beta1 on chondrogenic differentiation of human embryonic stem cells.
Stem cells and development 2009;18(6):929-40.
2009: Xiao Chen; Xing-Hui Song; Zi Yin; Xiao-Hui Zou; Lin-Lin Wang; Hu Hu; tong cao; Minghao Zheng; Hong Wei Ouyang
Stepwise differentiation of human embryonic stem cells promotes tendon regeneration by secreting fetal tendon matrix and differentiation factors.
Stem cells (Dayton, Ohio) 2009;27(6):1276-87.
2009: Zigang Ge; Xianfeng Tian; Boon Chin Heng; Victor Fan; Jin-Fei Yeo; tong cao
Histological evaluation of osteogenesis of 3D-printed poly-lactic-co-glycolic acid (PLGA) scaffolds in a rabbit model.
Biomedical materials (Bristol, England) 2009;4(2):021001.
2008: Kumar Jayaseelan Vinoth; Boon Chin Heng; Anuradha Poonepalli; Birendranath Banerjee; Lakshmidevi Balakrishnan; Kai Lu; M Prakash Hande; tong cao
Human embryonic stem cells may display higher resistance to genotoxic stress as compared to primary explanted somatic cells.
Stem cells and development 2008;17(3):599-607.
2008: Boon Chin Heng; Wei Seong Toh; Barry Peter Pereira; Bee-Leng Tan; Xin Fu; Hua Liu; Kai Lu; Jin-Fei Yeo; tong cao
An autologous cell lysate extract from human embryonic stem cell (hESC) derived osteoblasts can enhance osteogenesis of hESC.
Tissue & cell 2008;40(3):219-28.
2008: tong cao; Kai Lu; Xin Fu; Boon Chin Heng
Differentiated fibroblastic progenies of human embryonic stem cells for toxicology screening.
Cloning and stem cells 2008;10(1):1-10.
2008: X-F Tian; Boon Chin Heng; Zigang Ge; K Lu; Abdul Jalil Rufaihah; V T-W Fan; Jin-Fei Yeo; tong cao
Comparison of osteogenesis of human embryonic stem cells within 2D and 3D culture systems.
Scandinavian journal of clinical and laboratory investigation 2008;68(1):58-67.
2007: Boon Chin Heng; Marie-Veronique Clement; tong cao
Caspase inhibitor Z-VAD-FMK enhances the freeze-thaw survival rate of human embryonic stem cells.
Bioscience reports 2007;27(4-5):257-64.
2007: Abdul Jalil Rufaihah; Husnain Khawaja Haider; Boon Chin Heng; Lei Ye; Wei Seong Toh; Xian Feng Tian; Kai Lu; Eugene K W Sim; tong cao
Directing endothelial differentiation of human embryonic stem cells via transduction with an adenoviral vector expressing the VEGF(165) gene.
The journal of gene medicine 2007;9(6):452-61.
2007: Boon Chin Heng; Hua Liu; Zigang Ge; tong cao
Mechanical dissociation of human embryonic stem cell colonies by manual scraping after collagenase treatment is much more detrimental to cellular viability than is trypsinization with gentle pipetting.
Biotechnology and applied biochemistry 2007;47(Pt 1):33-7.
2007: Chao Peng Ye; Boon Chin Heng; Hua Liu; Wei Seong Toh; tong cao
Culture media conditioned by heat-shocked osteoblasts enhances the osteogenesis of bone marrow-derived mesenchymal stromal cells.
Cell biochemistry and function 2007;25(3):267-76.
2007: Wei Seong Toh; Zheng Yang; Hua Liu; Boon Chin Heng; Eng Hin Lee; tong cao
Effects of culture conditions and bone morphogenetic protein 2 on extent of chondrogenesis from human embryonic stem cells.
Stem cells (Dayton, Ohio) 2007;25(4):950-60.
2007: Wei Seong Toh; Zheng Yang; Boon Chin Heng; tong cao
Differentiation of human embryonic stem cells toward the chondrogenic lineage.
Methods in molecular biology (Clifton, N.J.) 2007;407():333-49.
2006: Boon Chin Heng; Chao Peng Ye; Hua Liu; Wei Seong Toh; Abdul Jalil Rufaihah; tong cao
Kinetics of cell death of frozen-thawed human embryonic stem cell colonies is reversibly slowed down by exposure to low temperature.
Zygote (Cambridge, England) 2006;14(4):341-8.
2006: Hong Wei Ouyang; tong cao; Xiao Hui Zou; Boon Chin Heng; Ling Ling Wang; Xing Hui Song; He-feng Huang
Mesenchymal stem cell sheets revitalize nonviable dense grafts: implications for repair of large-bone and tendon defects.
Transplantation 2006;82(2):170-4.
2006: Zigang Ge; Yang Hu; Boon Chin Heng; Zheng Yang; Hongwei Ouyang; Eng Hin Lee; tong cao
Osteoarthritis and therapy.
Arthritis and rheumatism 2006;55(3):493-500.
2006: Boon Chin Heng; Chao Peng Ye; Hua Liu; Wei Seong Toh; Abdul Jalil Rufaihah; Zheng Yang; Boon-Huat Bay; Zigang Ge; Hong Wei Ouyang; Eng Hin Lee; tong cao
Loss of viability during freeze-thaw of intact and adherent human embryonic stem cells with conventional slow-cooling protocols is predominantly due to apoptosis rather than cellular necrosis.
Journal of biomedical science 2006;13(3):433-45.
2006: Boon Chin Heng; Hua Liu; Abdul Jalil Rufaihah; tong cao
Human embryonic stem cell (hES) colonies display a higher degree of spontaneous differentiation when passaged at lower densities.
In vitro cellular & developmental biology. Animal 2006;42(3-4):54-7.
2006: Hua Liu; David M Kemeny; Boon Chin Heng; Hong Wei Ouyang; Alirio J Melendez; tong cao
The immunogenicity and immunomodulatory function of osteogenic cells differentiated from mesenchymal stem cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):2864-71.
2006: Boon Chin Heng; Kumar Jayaseelan Vinoth; Hua Liu; M Prakash Hande; tong cao
Low temperature tolerance of human embryonic stem cells.
International journal of medical sciences 2006;3(4):124-9.
2006: Wei Seong Toh; Zheng Yang; Boon Chin Heng; tong cao
New perspectives in chondrogenic differentiation of stem cells for cartilage repair.
TheScientificWorldJournal 2006;6():361-4.
2005: Wei Seong Toh; Hua Liu; Boon Chin Heng; Abdul Jalil Rufaihah; Chao Peng Ye; tong cao
Combined effects of TGFbeta1 and BMP2 in serum-free chondrogenic differentiation of mesenchymal stem cells induced hyaline-like cartilage formation.
Growth factors (Chur, Switzerland) 2005;23(4):313-21.
2005: Boon Chin Heng; Ian K McNiece; Husnain Khawaja Haider; Roy Yorke Calne; tong cao
Possible advantages of stem cell transfusion into the peripheral circulation, as opposed to localized transplantation in situ.
Stem cells and development 2005;14(4):351-3.
2005: tong cao; Boon Chin Heng; Chao Peng Ye; Hua Liu; Wei Seong Toh; Paul Robson; Pin Li; Yun Han Hong; Lawrence W Stanton
Osteogenic differentiation within intact human embryoid bodies result in a marked increase in osteocalcin secretion after 12 days of in vitro culture, and formation of morphologically distinct nodule-like structures.
Tissue & cell 2005;37(4):325-34.
2005: Boon Chin Heng; Yun Han Hong; tong cao
Modulating gene expression in stem cells without recombinant DNA and permanent genetic modification.
Cell and tissue research 2005;321(2):147-50.
2005: Boon Chin Heng; tong cao; Husnain Khawaja Haider; Abdul Jalil Rufaihah; Eugene K W Sim
Utilizing stem cells for myocardial repair--to differentiate or not to differentiate prior to transplantation?
Scandinavian cardiovascular journal : SCJ 2005;39(3):131-4.
2005: Boon Chin Heng; Hanry Yu; Yijun Yin; Seng Gee Lim; tong cao
Factors influencing stem cell differentiation into the hepatic lineage in vitro.
Journal of gastroenterology and hepatology 2005;20(7):975-87.
2005: Bina Rai; Swee-Hin Teoh; Dietmar W Hutmacher; tong cao; Kee-Hai Ho
Novel PCL-based honeycomb scaffolds as drug delivery systems for rhBMP-2.
Biomaterials 2005;26(17):3739-48.
2005: Boon Chin Heng; Husnain Khawaja Haider; Eugene K W Sim; tong cao; Guo Qing Tong; Soon Chye Ng
Reprogramming autologous skeletal myoblasts to express cardiomyogenic function. Challenges and possible approaches.
International journal of cardiology 2005;100(3):355-62.
2005: Boon Chin Heng; tong cao
Incorporating protein transduction domains (PTD) within recombinant 'fusion' transcription factors. A novel strategy for directing stem cell differentiation?
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2005;59(3):132-4.
2005: Boon Chin Heng; Lilia L Kuleshova; Soren Müller Bested; Hua Liu; tong cao
The cryopreservation of human embryonic stem cells.
Biotechnology and applied biochemistry 2005;41(Pt 2):97-104.
2005: Boon Chin Heng; Soren Müller Bested; Swee H Chan; tong cao
A proposed design for the cryopreservation of intact and adherent human embryonic stem cell colonies.
In vitro cellular & developmental biology. Animal 2005;41(3-4):77-9.
2005: tong cao; Tzuen Yih Saw; Boon Chin Heng; Hua Liu; Adrian U J Yap; Mah-Lee Ng
Comparison of different test models for the assessment of cytotoxicity of composite resins.
Journal of applied toxicology : JAT 2005;25(2):101-8.
2005: Boon Chin Heng; tong cao; Hua Liu; Abdul Jalil Rufaihah
Reduced mitotic activity at the periphery of human embryonic stem cell colonies cultured in vitro with mitotically-inactivated murine embryonic fibroblast feeder cells.
Cell biochemistry and function 2005;23(2):141-6.
2005: Boon Chin Heng; Husnain Khawaja Haider; Eugene K W Sim; tong cao; Guo Qing Tong; Soon Chye Ng
Comments about possible use of human embryonic stem cell-derived cardiomyocytes to direct autologous adult stem cells into the cardiomyogenic lineage.
Acta cardiologica 2005;60(1):7-12.
2005: Boon Chin Heng; tong cao; Soren Müller Bested; Guo Qing Tong; Soon Chye Ng
"Waste" follicular aspirate from fertility treatment--a potential source of human germline stem cells?
Stem cells and development 2005;14(1):11-4.
2005: Tzuen Yih Saw; tong cao; Adrian U J Yap; Mary Mah Lee Ng
Tooth slice organ culture and established cell line culture models for cytotoxicity assessment of dental materials.
Toxicology in vitro : an international journal published in association with BIBRA 2005;19(1):145-54.
2005: Boon Chin Heng; Hua Liu; tong cao
Late-adhering human embryonic stem cell clumps during serial passage can yield morphologically 'normal-looking' colonies.
Annals of clinical and laboratory science 2005;35(4):459-62.
2005: tong cao; Boon Chin Heng
Intracellular antibodies (intrabodies) versus RNA interference for therapeutic applications.
Annals of clinical and laboratory science 2005;35(3):227-9.
2005: Boon Chin Heng; Husnain Khawaja Haider; tong cao
Combining transfusion of stem/progenitor cells into the peripheral circulation with localized transplantation in situ at the site of tissue/organ damage: a possible strategy to optimize the efficacy of stem cell transplantation therapy.
Medical hypotheses 2005;65(3):494-7.
2005: Boon Chin Heng; tong cao
Immunoliposome-mediated delivery of neomycin phosphotransferase for the lineage-specific selection of differentiated/committed stem cell progenies: potential advantages over transfection with marker genes, fluorescence-activated and magnetic affinity cell-sorting.
Medical hypotheses 2005;65(2):334-6.
2005: Boon Chin Heng; tong cao
Making cell-permeable antibodies (Transbody) through fusion of protein transduction domains (PTD) with single chain variable fragment (scFv) antibodies: potential advantages over antibodies expressed within the intracellular environment (Intrabody).
Medical hypotheses 2005;64(6):1105-8.
2005: Boon Chin Heng; Hua Liu; tong cao
Transplanted human embryonic stem cells as biological 'catalysts' for tissue repair and regeneration.
Medical hypotheses 2005;64(6):1085-8.
2005: Boon Chin Heng; David M Kemeny; Hua Liu; tong cao
Potential applications of intracellular antibodies (intrabodies) in stem cell therapeutics.
Journal of cellular and molecular medicine 2005;9(1):191-5.
2005: Boon Chin Heng; tong cao
Incorporating protein transduction domains (PTD) within intracellular proteins associated with the 'stemness' phenotype. Novel use of such recombinant 'fusion' proteins to overcome current limitations of applying autologous adult stem cells in regenerative medicine?
Medical hypotheses 2005;64(5):992-6.
2005: Boon Chin Heng; tong cao; Hua Liu; Toan-Thang Phan
Directing stem cells into the keratinocyte lineage in vitro.
Experimental dermatology 2005;14(1):1-16.
2004: X H Zou; W C Foong; tong cao; Boon-Huat Bay; Hong Wei Ouyang; G W Yip
Chondroitin sulfate in palatal wound healing.
Journal of dental research 2004;83(11):880-5.
2004: Bina Rai; Swee-Hin Teoh; Kee-Hai Ho; Dietmar W Hutmacher; tong cao; Fulin Chen; K Yacob
The effect of rhBMP-2 on canine osteoblasts seeded onto 3D bioactive polycaprolactone scaffolds.
Biomaterials 2004;25(24):5499-506.
2004: Boon Chin Heng; tong cao; Guo Qing Tong; Soon Chye Ng
Potential utility of cell-permeable transcription factors to direct stem cell differentiation.
Stem cells and development 2004;13(5):460-2.
2004: Boon Chin Heng; Hua Liu; tong cao
Feeder cell density--a key parameter in human embryonic stem cell culture.
In vitro cellular & developmental biology. Animal 2004;40(8-9):255-7.
2004: Boon Chin Heng; tong cao; Lawrence W Stanton; Paul Robson; Bjorn Olsen
Strategies for directing the differentiation of stem cells into the osteogenic lineage in vitro.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(9):1379-94.
2004: Boon Chin Heng; Husnain Kh Haider; Eugene K W Sim; tong cao; Soon Chye Ng
Strategies for directing the differentiation of stem cells into the cardiomyogenic lineage in vitro.
Cardiovascular research 2004;62(1):34-42.
2004: Boon Chin Heng; tong cao; Husnain Khawaja Haider; Dennis Zheng Ming Wang; Eugene K W Sim; Soon Chye Ng
An overview and synopsis of techniques for directing stem cell differentiation in vitro.
Cell and tissue research 2004;315(3):291-303.
2004: Boon Chin Heng; tong cao; Eng Hin Lee
Directing stem cell differentiation into the chondrogenic lineage in vitro.
Stem cells (Dayton, Ohio) 2004;22(7):1152-67.
2004: Adrian U J Yap; Tzuen Yih Saw; tong cao; Mary M L Ng
Composite cure and pulp-cell cytotoxicity associated with LED curing lights.
Operative dentistry 2004;29(1):92-9.
2003: T S Lo; Siew Han Chay; tong cao; Jane Lim; Swee-Hin Teoh
Osteogenic role of vascular endothelial growth factor in bone regeneration.
Annals of the Academy of Medicine, Singapore 2003;32(5 Suppl):S50-1.
2003: tong cao; Kee-Hai Ho; Swee-Hin Teoh
Scaffold design and in vitro study of osteochondral coculture in a three-dimensional porous polycaprolactone scaffold fabricated by fused deposition modeling.
Tissue engineering 2003;9 Suppl 1():S103-12.