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Cesare Montecucco

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Ornella Rossetto; M Scorzeto; Aram Megighian; Cesare Montecucco
Botulinum neurotoxins.
Ornella Rossetto; M Scorzeto; Aram Megighian; Cesare Montecucco
Tetanus neurotoxin.
Roberto Eleopra; Christian Lettieri; Cesare Montecucco; Marco Pirazzini; Sara Rinaldo; Paola Caccin; Grazia Devigili; Lorenzo Verriello; Ornella Rossetto
Botulinum neurotoxin serotype D is poorly effective in humans: An in vivo electrophysiological study.

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All Publications

2013: Ornella Rossetto; M Scorzeto; Aram Megighian; Cesare Montecucco
Botulinum neurotoxins.
Toxicon : official journal of the International Society on Toxinology 2013;67():31-6.
2013: Ornella Rossetto; M Scorzeto; Aram Megighian; Cesare Montecucco
Tetanus neurotoxin.
Toxicon : official journal of the International Society on Toxinology 2013;66():59-63.
2013: Roberto Eleopra; Christian Lettieri; Cesare Montecucco; Marco Pirazzini; Sara Rinaldo; Paola Caccin; Grazia Devigili; Lorenzo Verriello; Ornella Rossetto
Botulinum neurotoxin serotype D is poorly effective in humans: An in vivo electrophysiological study.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2013;124(5):999-1004.
2013: Elisa Duregotti; Cesare Montecucco; Erik Tedesco; Michela Rigoni
Calpains participate in nerve terminal degeneration induced by spider and snake presynaptic neurotoxins.
Toxicon : official journal of the International Society on Toxinology 2013;64():20-8.
2013: Daniela S P Silva; Irene Zornetta; Jorge E Azevedo; Rui M Brito; Ana do Vale; Tiago Q Faria; Frederico Ferreira-da-Silva; Sandra Macedo-Ribeiro; Cesare Montecucco; Ana R Moreira; Pedro Oliveira; Liliana M G Pereira; Pedro J B Pereira; Nuno M S dos Santos
The apoptogenic toxin AIP56 is a metalloprotease A-B toxin that cleaves NF-κb P65.
PLoS pathogens 2013;9(2):e1003128.
2013: Paola Caccin; Mariana Cintra-Francischinelli; Francesco Di Virgilio; Julián Fernandez; José María Gutiérrez; Bruno Lomonte; Patrizia Pellegatti; Maria Vono; Cesare Montecucco
Why myotoxin-containing snake venoms possess powerful nucleotidases?
Biochemical and biophysical research communications 2013;430(4):1289-93.
2013: Marco Pirazzini; Ornella Rossetto; Clifford C Shone; Thomas Binz; Fulvio Bordin; Cesare Montecucco
The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals.
FEBS letters 2013;587(2):150-5.
2013: Marco Pirazzini; Ornella Rossetto; Clifford C Shone; Cristina Bertasio; Thomas Binz; Fulvio Bordin; Cesare Montecucco
Time course and temperature dependence of the membrane translocation of tetanus and botulinum neurotoxins C and D in neurons.
Biochemical and biophysical research communications 2013;430(1):38-42.
2012: Irene Zornetta; Paola Caccin; Julián Fernandez; José María Gutierrez; Bruno Lomonte; Cesare Montecucco
Envenomations by Bothrops and Crotalus snakes induce the release of mitochondrial alarmins.
PLoS neglected tropical diseases 2012;6(2):e1526.
2011: Marco Pirazzini; Ornella Rossetto; Clifford C Shone; Paolo Bolognese; Cesare Montecucco
Double anchorage to the membrane and intact inter-chain disulfide bond are required for the low pH induced entry of tetanus and botulinum neurotoxins into neurons.
Cellular microbiology 2011;13(11):1731-43.
2010: Paola Caccin; Anna Magnabosco; Erik Tedesco; Livia Silva-Cardoso; Georgia C Atella; Cesare Montecucco
Lysophospholipids are evolutionary ancient venom components.
Toxicon : official journal of the International Society on Toxinology 2010;56(8):1525-7.
2010: Lívia Silva-Cardoso; Paola Caccin; Anna Magnabosco; Maria Patrón; Mariane Targino; André Fuly; Giselle A Oliveira; Marcos H Pereira; Maria das Graças T do Carmo; Amanda Santos de Souza; Mario Silva-Neto; Cesare Montecucco; Georgia C Atella
Paralytic activity of lysophosphatidylcholine from saliva of the waterbug Belostoma anurum.
The Journal of experimental biology 2010;213(Pt 19):3305-10.
2010: Aram Megighian; Michele Scorzeto; Damiano Zanini; Sergio Pantano; Michela Rigoni; Clara Benna; Ornella Rossetto; Cesare Montecucco; Mauro Zordan
Arg206 of SNAP-25 is essential for neuroexocytosis at the Drosophila melanogaster neuromuscular junction.
Journal of cell science 2010;123(Pt 19):3276-83.
2010: Bazbek Davletov; Cesare Montecucco
Lipid function at synapses.
Current opinion in neurobiology 2010;20(5):543-9.
2010: Irene Zornetta; Lucia Brandi; Blythe Janowiak; Federica Dal Molin; Fiorella Tonello; R John Collier; Cesare Montecucco
Imaging the cell entry of the anthrax oedema and lethal toxins with fluorescent protein chimeras.
Cellular microbiology 2010;12(10):1435-45.
2010: Mariana Cintra-Francischinelli; Paola Caccin; Angela Chiavegato; Paola Pizzo; Giorgio Carmignoto; Yamileth Angulo; Bruno Lomonte; José María Gutiérrez; Cesare Montecucco
Bothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and pain.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(32):14140-5.
2010: Mariana Cintra-Francischinelli; Paola Pizzo; Yamileth Angulo; José M Gutiérrez; Cesare Montecucco; Bruno Lomonte
The C-terminal region of a Lys49 myotoxin mediates Ca2+ influx in C2C12 myotubes.
Toxicon : official journal of the International Society on Toxinology 2010;55(2-3):590-6.
2010: Paola Fogar; Filippo Navaglia; Daniela Basso; Carlo-Federico Zambon; Lidia Moserle; Stefano Indraccolo; Alessia Stranges; Eliana Greco; Elisa Fadi; A Padoan; G Pantano; Maria Colomba Sanzari; Sergio Pedrazzoli; Cesare Montecucco; Mario Plebani
Heat-induced transcription of diphtheria toxin A or its variants, CRM176 and CRM197: implications for pancreatic cancer gene therapy.
Cancer gene therapy 2010;17(1):58-68.
2009: Michèle Mock; Cesare Montecucco
Editorial.
Molecular aspects of medicine 2009;30(6):345-6.
2009: Fiorella Tonello; Cesare Montecucco
The anthrax lethal factor and its MAPK kinase-specific metalloprotease activity.
Molecular aspects of medicine 2009;30(6):431-8.
2009: Marco Paoli; Michela Rigoni; Grielof Koster; Ornella Rossetto; Cesare Montecucco; Anthony D Postle
Mass spectrometry analysis of the phospholipase A(2) activity of snake pre-synaptic neurotoxins in cultured neurons.
Journal of neurochemistry 2009;111(3):737-44.
2009: Cesare Montecucco; Ornella Rossetto; Paola Caccin; Michela Rigoni; Luca Carli; Laura Morbiato; Lucia Muraro; Marco Paoli
Different mechanisms of inhibition of nerve terminals by botulinum and snake presynaptic neurotoxins.
Toxicon : official journal of the International Society on Toxinology 2009;54(5):561-4.
2009: Luca Carli; Cesare Montecucco; Ornella Rossetto
Assay of diffusion of different botulinum neurotoxin type a formulations injected in the mouse leg.
Muscle & nerve 2009;40(3):374-80.
2009: Erik Tedesco; Michela Rigoni; Paola Caccin; Eugene Grishin; Ornella Rossetto; Cesare Montecucco
Calcium overload in nerve terminals of cultured neurons intoxicated by alpha-latrotoxin and snake PLA2 neurotoxins.
Toxicon : official journal of the International Society on Toxinology 2009;54(2):138-44.
2009: Federico Fogolari; Silvio C E Tosatto; Lucia Muraro; Cesare Montecucco
Electric dipole reorientation in the interaction of botulinum neurotoxins with neuronal membranes.
FEBS letters 2009;583(14):2321-5.
2009: Vasiliki Liakouli; Mirko Manetti; Alessandra Pacini; B Tolusso; C Fatini; Annarita Toscano; Paola Cipriani; Serena Guiducci; L Bazzichi; V Codullo; L Ruocco; L Dell'orso; F Carubbi; Alessandra Marrelli; Rosanna Abbate; Stefano Bombardieri; G Ferraccioli; Cesare Montecucco; Gabriele Valentini; Marco Matucci-Cerinic; Lidia Ibba-Manneschi; Roberto Giacomelli
The -670G>A polymorphism in the FAS gene promoter region influences the susceptibility to systemic sclerosis.
Annals of the rheumatic diseases 2009;68(4):584-90.
2009: Silvia Rossi Paccani; Marisa Benagiano; Nagaja Capitani; Irene Zornetta; Daniel Ladant; Cesare Montecucco; Mario Milco D'Elios; Cosima T Baldari
The adenylate cyclase toxins of Bacillus anthracis and Bordetella pertussis promote Th2 cell development by shaping T cell antigen receptor signaling.
PLoS pathogens 2009;5(3):e1000325.
2009: Paola Caccin; Ornella Rossetto; Cesare Montecucco
Neurotoxicity of inverted-cone shaped lipids.
Neurotoxicology 2009;30(2):174-81.
2009: Mirko Manetti; Vasiliki Liakouli; Cinzia Fatini; Paola Cipriani; C Bonino; S Vettori; Serena Guiducci; Cesare Montecucco; Rosanna Abbate; Gabriele Valentini; Marco Matucci-Cerinic; Roberto Giacomelli; Lidia Ibba-Manneschi
Association between a stromal cell-derived factor 1 (SDF-1/CXCL12) gene polymorphism and microvascular disease in systemic sclerosis.
Annals of the rheumatic diseases 2009;68(3):408-11.
2009: Lucia Muraro; Silvio Tosatto; Lisa Motterlini; Ornella Rossetto; Cesare Montecucco
The N-terminal half of the receptor domain of botulinum neurotoxin A binds to microdomains of the plasma membrane.
Biochemical and biophysical research communications 2009;380(1):76-80.
2008: Michela Rigoni; Marco Paoli; Eva Milanesi; Paola Caccin; Andrea Rasola; Paolo Bernardi; Cesare Montecucco
Snake phospholipase A2 neurotoxins enter neurons, bind specifically to mitochondria, and open their transition pores.
The Journal of biological chemistry 2008;283(49):34013-20.
2008: Federica Dal Molin; Antonio Fasanella; Morena Simonato; Giuliano Garofolo; Cesare Montecucco; Fiorella Tonello
Ratio of lethal and edema factors in rabbit systemic anthrax.
Toxicon : official journal of the International Society on Toxinology 2008;52(7):824-8.
2008: Federica Dal Molin; Irene Zornetta; Andrea Puhar; Fiorella Tonello; Manuela Zaccolo; Cesare Montecucco
cAMP imaging of cells treated with pertussis toxin, cholera toxin, and anthrax edema toxin.
Biochemical and biophysical research communications 2008;376(2):429-33.
2008: Gaia Codolo; Amedeo Amedei; Allen C Steere; Elena Papinutto; Andrea Cappon; Alessandra Polenghi; Marisa Benagiano; Silvia Rossi Paccani; vittorio sambri; Gianfranco Del Prete; Cosima T Baldari; Giuseppe Zanotti; Cesare Montecucco; Mario Milco D'Elios; Marina de Bernard
Borrelia burgdorferi NapA-driven Th17 cell inflammation in lyme arthritis.
Arthritis and rheumatism 2008;58(11):3609-17.
2008: Silvia Rossi Paccani; Federica Dal Molin; Marisa Benagiano; Daniel Ladant; Mario Milco D'Elios; Cesare Montecucco; Cosima T Baldari
Suppression of T-lymphocyte activation and chemotaxis by the adenylate cyclase toxin of Bordetella pertussis.
Infection and immunity 2008;76(7):2822-32.
2008: michael hudson; Wolfgang Beyer; Reinhard Böhm; Antonio Fasanella; Giuliano Garofolo; Robert Golinski; Pierre L Goossens; Ulrike Hahn; Bassam Hallis; Annemarie King; Michèle Mock; Cesare Montecucco; Amanda Ozin; Fiorella Tonello; Stefan H E Kaufmann
Bacillus anthracis: balancing innocent research with dual-use potential.
International journal of medical microbiology : IJMM 2008;298(5-6):345-64.
2008: Cesare Montecucco; Ornella Rossetto
On the quaternary structure of taipoxin and textilotoxin: the advantage of being multiple.
Toxicon : official journal of the International Society on Toxinology 2008;51(8):1560-2.
2008: Diletta Arcidiacono; Sandra Odom; Barbara Frossi; Juan Rivera; Silvia R Paccani; Cosima T Baldari; Carlo Pucillo; Cesare Montecucco; Marina de Bernard
The Vibrio cholerae cytolysin promotes activation of mast cell (T helper 2) cytokine production.
Cellular microbiology 2008;10(4):899-907.
2008: Andrea Puhar; Federica Dal Molin; Stéphanie Horvath; Daniel Ladant; Daniel Ladants; Cesare Montecucco
Anthrax edema toxin modulates PKA- and CREB-dependent signaling in two phases.
PloS one 2008;3(10):e3564.
2008: Eric A Johnson; Cesare Montecucco
Botulism.
Handbook of clinical neurology 2008;91():333-68.
2008: Ornella Rossetto; Cesare Montecucco
Presynaptic neurotoxins with enzymatic activities.
Handbook of experimental pharmacology 2008;(184):129-70.
2007: Andrea Puhar; Cesare Montecucco
Where and how do anthrax toxins exit endosomes to intoxicate host cells?
Trends in microbiology 2007;15(11):477-82.
2007: Laura Cendron; Elisabetta Tasca; Tommaso Seraglio; Anke Seydel; Alessandro Angelini; Roberto Battistutta; Cesare Montecucco; Giuseppe Zanotti
The crystal structure of CagS from the Helicobacter pylori pathogenicity island.
Proteins 2007;69(2):440-3.
2007: Christophe Genisset; Andrea Puhar; Federica Calore; Marina de Bernard; Paolo Dell'Antone; Cesare Montecucco
The concerted action of the Helicobacter pylori cytotoxin VacA and of the v-ATPase proton pump induces swelling of isolated endosomes.
Cellular microbiology 2007;9(6):1481-90.
2007: Laura Morbiato; Luca Carli; Eric A Johnson; Cesare Montecucco; Jordi Molgó; Ornella Rossetto
Neuromuscular paralysis and recovery in mice injected with botulinum neurotoxins A and C.
The European journal of neuroscience 2007;25(9):2697-704.
2007: Mario Milco D'Elios; Cesare Montecucco; Marina de Bernard
VacA and HP-NAP, Ying and Yang of Helicobacter pylori-associated gastric inflammation.
Clinica chimica acta; international journal of clinical chemistry 2007;381(1):32-8.
2007: Matteo Caleo; Laura Restani; Laura Gianfranceschi; Laura Costantin; Chiara Rossi; Ornella Rossetto; Cesare Montecucco; Lamberto Maffei
Transient synaptic silencing of developing striate cortex has persistent effects on visual function and plasticity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(17):4530-40.
2007: Michela Rigoni; Paola Pizzo; Giampietro Schiavo; Anne E Weston; Giancarlo Zatti; Paola Caccin; Ornella Rossetto; Tullio Pozzan; Cesare Montecucco
Calcium influx and mitochondrial alterations at synapses exposed to snake neurotoxins or their phospholipid hydrolysis products.
The Journal of biological chemistry 2007;282(15):11238-45.
2007: Aram Megighian; Michela Rigoni; Paola Caccin; Mauro A Zordan; Cesare Montecucco
A lysolecithin/fatty acid mixture promotes and then blocks neurotransmitter release at the Drosophila melanogaster larval neuromuscular junction.
Neuroscience letters 2007;416(1):6-11.
2007: Daniel Giner; Inmaculada López; Patricia Neco; Ornella Rossetto; Cesare Montecucco; Luis M Gutiérrez
Glycogen synthase kinase 3 activation is essential for the snake phospholipase A2 neurotoxin-induced secretion in chromaffin cells.
The European journal of neuroscience 2007;25(8):2341-8.
2007: Silvia Rossi Paccani; Fiorella Tonello; Laura Patrussi; Nagaja Capitani; Morena Simonato; Cesare Montecucco; Cosima T Baldari
Anthrax toxins inhibit immune cell chemotaxis by perturbing chemokine receptor signalling.
Cellular microbiology 2007;9(4):924-9.
2007: Ornella Rossetto; Cesare Montecucco
Peculiar binding of botulinum neurotoxins.
ACS chemical biology 2007;2(2):96-8.
2007: Claudia Verderio; Carlotta Grumelli; Luca Raiteri; Silvia Coco; Silvio Paluzzi; Paola Caccin; Ornella Rossetto; Giambattista Bonanno; Cesare Montecucco; Michela Matteoli
Traffic of botulinum toxins A and E in excitatory and inhibitory neurons.
Traffic (Copenhagen, Denmark) 2007;8(2):142-53.
2007: Alessandra Polenghi; Fleur Bossi; Fabio Fischetti; Paolo Durigutto; Anna Cabrelle; Nicola Tamassia; Marco A Cassatella; Cesare Montecucco; Francesco Tedesco; Marina de Bernard
The neutrophil-activating protein of Helicobacter pylori crosses endothelia to promote neutrophil adhesion in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(3):1312-20.
2006: Paola Caccin; Michela Rigoni; Alessandra Bisceglie; Ornella Rossetto; Cesare Montecucco
Reversible skeletal neuromuscular paralysis induced by different lysophospholipids.
FEBS letters 2006;580(27):6317-21.
2006: Federica Dal Molin; Fiorella Tonello; Daniel Ladant; Irene Zornetta; Ilaria Zamparo; Giulietta Di Benedetto; Manuela Zaccolo; Cesare Montecucco
Cell entry and cAMP imaging of anthrax edema toxin.
The EMBO journal 2006;25(22):5405-13.
2006: Cesare Montecucco; Maurizio Molinari
Microbiology: death of a chaperone.
Nature 2006;443(7111):511-2.
2006: Claudia Verderio; Ornella Rossetto; Carlotta Grumelli; Carolina Frassoni; Cesare Montecucco; Michela Matteoli
Entering neurons: botulinum toxins and synaptic vesicle recycling.
EMBO reports 2006;7(10):995-9.
2006: Cosima T Baldari; Fiorella Tonello; Silvia Rossi Paccani; Cesare Montecucco
Anthrax toxins: A paradigm of bacterial immune suppression.
Trends in immunology 2006;27(9):434-40.
2006: Giovanna Barbuti; Monica Moschioni; Stefano Censini; Antonello Covacci; Cesare Montecucco; Pasqualina Montemurro
Streptococcus pneumoniae induces mast cell degranulation.
International journal of medical microbiology : IJMM 2006;296(4-5):325-9.
2006: Ornella Rossetto; Laura Morbiato; Paola Caccin; Michela Rigoni; Cesare Montecucco
Presynaptic enzymatic neurotoxins.
Journal of neurochemistry 2006;97(6):1534-45.
2006: Siro Luvisetto; Sara Marinelli; Francesco Lucchetti; Fabrizio Marchi; Stefano Cobianchi; Ornella Rossetto; Cesare Montecucco; Flaminia Pavone
Botulinum neurotoxins and formalin-induced pain: central vs. peripheral effects in mice.
Brain research 2006;1082(1):124-31.
2006: Roberto Eleopra; Valeria Tugnoli; Rocco Quatrale; Ornella Rossetto; Cesare Montecucco; Dirk Dressler
Clinical use of non-A botulinum toxins: botulinum toxin type C and botulinum toxin type F.
Neurotoxicity research 2006;9(2-3):127-31.
2006: Anton Thumiger; Alessandra Polenghi; Elena Papinutto; Roberto Battistutta; Cesare Montecucco; Giuseppe Zanotti
Crystal structure of antigen TpF1 from Treponema pallidum.
Proteins 2006;62(3):827-30.
2006: Marc Roger Couturier; Elizabetta Tasca; Cesare Montecucco; Markus Stein
Interaction with CagF is required for translocation of CagA into the host via the Helicobacter pylori type IV secretion system.
Infection and immunity 2006;74(1):273-81.
2006: Sergio Pantano; Cesare Montecucco
A molecular model of the Vibrio cholerae cytolysin transmembrane pore.
Toxicon : official journal of the International Society on Toxinology 2006;47(1):35-40.
2006: Vanina Romanello; M Marcacci; Federica Dal Molin; Monica Moschioni; Stefano Censini; Antonello Covacci; Aldo Baritussio; Cesare Montecucco; Fiorella Tonello
Cloning, expression, purification, and characterization of Streptococcus pneumoniae IgA1 protease.
Protein expression and purification 2006;45(1):142-9.
2005: Michela Rigoni; Paola Caccin; Stephen Gschmeissner; Grielof Koster; Anthony D Postle; Ornella Rossetto; Giampietro Schiavo; Cesare Montecucco
Equivalent effects of snake PLA2 neurotoxins and lysophospholipid-fatty acid mixtures.
Science (New York, N.Y.) 2005;310(5754):1678-80.
2005: Carlotta Grumelli; Claudia Verderio; Davide Pozzi; Ornella Rossetto; Cesare Montecucco; Michela Matteoli
Internalization and mechanism of action of clostridial toxins in neurons.
Neurotoxicology 2005;26(5):761-7.
2005: Cesare Montecucco; Giampietro Schiavo; Sergio Pantano
SNARE complexes and neuroexocytosis: how many, how close?
Trends in biochemical sciences 2005;30(7):367-72.
2005: Cesare Montecucco; Jordi Molgó
Botulinal neurotoxins: revival of an old killer.
Current opinion in pharmacology 2005;5(3):274-9.
2005: Dario Bonanomi; Maria Pennuto; Michela Rigoni; Ornella Rossetto; Cesare Montecucco; Flavia Valtorta
Taipoxin induces synaptic vesicle exocytosis and disrupts the interaction of synaptophysin I with VAMP2.
Molecular pharmacology 2005;67(6):1901-8.
2005: Jean-Nicolas Tournier; Anne Quesnel-Hellmann; Jacques Mathieu; Cesare Montecucco; Wei-Jen Tang; Michèle Mock; Dominique R Vidal; Pierre L Goossens
Anthrax edema toxin cooperates with lethal toxin to impair cytokine secretion during infection of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):4934-41.
2005: Laura Costantin; Yuri Bozzi; Cristina Richichi; Alessandro Viegi; Flavia Antonucci; Marcella Funicello; Marco Gobbi; Tiziana Mennini; Ornella Rossetto; Cesare Montecucco; Lamberto Maffei; Annamaria Vezzani; Matteo Caleo
Antiepileptic effects of botulinum neurotoxin E.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(8):1943-51.
2005: Silvia Rossi Paccani; Fiorella Tonello; Raffaella Ghittoni; Mariarita Natale; Lucia Muraro; Mario Milco D'Elios; Wei-Jen Tang; Cesare Montecucco; Cosima T Baldari
Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling.
The Journal of experimental medicine 2005;201(3):325-31.
2005: Marina de Bernard; Andrea Cappon; Laura Pancotto; Paolo Ruggiero; Juan Rivera; Giuseppe Del Giudice; Cesare Montecucco
The Helicobacter pylori VacA cytotoxin activates RBL-2H3 cells by inducing cytosolic calcium oscillations.
Cellular microbiology 2005;7(2):191-8.
2004: Cesare Montecucco; Ornella Rossetto; Giampietro Schiavo
Presynaptic receptor arrays for clostridial neurotoxins.
Trends in microbiology 2004;12(10):442-6.
2004: Michela Rigoni; Giampietro Schiavo; Anne E Weston; Paola Caccin; Federica Allegrini; Maria Pennuto; Flavia Valtorta; Cesare Montecucco; Ornella Rossetto
Snake presynaptic neurotoxins with phospholipase A2 activity induce punctate swellings of neurites and exocytosis of synaptic vesicles.
Journal of cell science 2004;117(Pt 16):3561-70.
2004: Andrea Puhar; Eric A Johnson; Ornella Rossetto; Cesare Montecucco
Comparison of the pH-induced conformational change of different clostridial neurotoxins.
Biochemical and biophysical research communications 2004;319(1):66-71.
2004: Cesare Montecucco; Fiorella Tonello; Giuseppe Zanotti
Stop the killer: how to inhibit the anthrax lethal factor metalloprotease.
Trends in biochemical sciences 2004;29(6):282-5.
2004: Siro Luvisetto; Sara Marinelli; Ornella Rossetto; Cesare Montecucco; Flaminia Pavone
Central injection of botulinum neurotoxins: behavioural effects in mice.
Behavioural pharmacology 2004;15(3):233-40.
2004: Marina de Bernard; Andrea Cappon; Giuseppe Del Giudice; Rino Rappuoli; Cesare Montecucco
The multiple cellular activities of the VacA cytotoxin of Helicobacter pylori.
International journal of medical microbiology : IJMM 2004;293(7-8):589-97.
2004: Ornella Rossetto; Michela Rigoni; Cesare Montecucco
Different mechanism of blockade of neuroexocytosis by presynaptic neurotoxins.
Toxicology letters 2004;149(1-3):91-101.
2004: Isabella Dell'Aica; Massimo Donà; Fiorella Tonello; Alejandro Piris; Michèle Mock; Cesare Montecucco; Spiridione Garbisa
Potent inhibitors of anthrax lethal factor from green tea.
EMBO reports 2004;5(4):418-22.
2004: Roberto Eleopra; Valeria Tugnoli; Rocco Quatrale; Ornella Rossetto; Cesare Montecucco
Different types of botulinum toxin in humans.
Movement disorders : official journal of the Movement Disorder Society 2004;19 Suppl 8():S53-9.
2004: Fiorella Tonello; Laura Naletto; Vanina Romanello; Federica Dal Molin; Cesare Montecucco
Tyrosine-728 and glutamic acid-735 are essential for the metalloproteolytic activity of the lethal factor of Bacillus anthracis.
Biochemical and biophysical research communications 2004;313(3):496-502.
2003: Cesare Montecucco; Marina de Bernard
Immunosuppressive and proinflammatory activities of the VacA toxin of Helicobacter pylori.
The Journal of experimental medicine 2003;198(12):1767-71.
2003: Fiorella Tonello; Paolo Ascenzi; Cesare Montecucco
The metalloproteolytic activity of the anthrax lethal factor is substrate-inhibited.
The Journal of biological chemistry 2003;278(41):40075-8.
2003: Cesare Montecucco; Marina de Bernard
Molecular and cellular mechanisms of action of the vacuolating cytotoxin (VacA) and neutrophil-activating protein (HP-NAP) virulence factors of Helicobacter pylori.
Microbes and infection / Institut Pasteur 2003;5(8):715-21.
2003: Paola Caccin; Ornella Rossetto; Michela Rigoni; Eric Johnson; Giampietro Schiavo; Cesare Montecucco
VAMP/synaptobrevin cleavage by tetanus and botulinum neurotoxins is strongly enhanced by acidic liposomes.
FEBS letters 2003;542(1-3):132-6.
2003: Patricia Neco; Ornella Rossetto; Anabel Gil; Cesare Montecucco; Luis M Gutiérrez
Taipoxin induces F-actin fragmentation and enhances release of catecholamines in bovine chromaffin cells.
Journal of neurochemistry 2003;85(2):329-37.
2003: Hiroaki Nishioka; Ilenia Baesso; Gianpietro Semenzato; Livio Trentin; Rino Rappuoli; Giuseppe Del Giudice; Cesare Montecucco
The neutrophil-activating protein of Helicobacter pylori (HP-NAP) activates the MAPK pathway in human neutrophils.
European journal of immunology 2003;33(4):840-9.
2003: Siro Luvisetto; Ornella Rossetto; Cesare Montecucco; Flaminia Pavone
Toxicity of botulinum neurotoxins in central nervous system of mice.
Toxicon : official journal of the International Society on Toxinology 2003;41(4):475-81.
2003: Patrizia Scapini; Bernardetta Nardelli; Gianpaolo Nadali; Federica Calzetti; Giovanni Pizzolo; Cesare Montecucco; Marco A Cassatella
G-CSF-stimulated neutrophils are a prominent source of functional BLyS.
The Journal of experimental medicine 2003;197(3):297-302.
2002: Paolo Ascenzi; Paolo Visca; giuseppe ippolito; Andrea Spallarossa; Martino Bolognesi; Cesare Montecucco
Anthrax toxin: a tripartite lethal combination.
FEBS letters 2002;531(3):384-8.
2002: Anke Seydel; Elisabetta Tasca; Duccio Berti; Rino Rappuoli; Giuseppe Del Giudice; Cesare Montecucco
Characterization and immunogenicity of the CagF protein of the cag pathogenicity island of Helicobacter pylori.
Infection and immunity 2002;70(11):6468-70.
2002: Giuseppe Zanotti; Elena Papinutto; William G Dundon; Roberto Battistutta; Michela Seveso; Giuseppe Giudice; Rino Rappuoli; Cesare Montecucco
Structure of the neutrophil-activating protein from Helicobacter pylori.
Journal of molecular biology 2002;323(1):125-30.
2002: Roberto Eleopra; Valeria Tugnoli; Rocco Quatrale; Ernesto Gastaldo; Ornella Rossetto; Domenico De Grandis; Cesare Montecucco
Botulinum neurotoxin serotypes A and C do not affect motor units survival in humans: an electrophysiological study by motor units counting.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2002;113(8):1258-64.
2002: Fiorella Tonello; Michela Seveso; Oriano Marin; Michèle Mock; Cesare Montecucco
Screening inhibitors of anthrax lethal factor.
Nature 2002;418(6896):386.
2002: Monica Moschioni; Francesco Tombola; Marina de Bernard; Ana Coelho; Alexander Zitzer; Mario Zoratti; Cesare Montecucco
The Vibrio cholerae haemolysin anion channel is required for cell vacuolation and death.
Cellular microbiology 2002;4(7):397-409.
2002: Valeria Tugnoli; Rosario Marchese-Ragona; Roberto Eleopra; Rocco Quatrale; Jay Guido Capone; antonio pastore; Cesare Montecucco; Domenico De Grandis
The role of gustatory flushing in Frey's syndrome and its treatment with botulinum toxin type A.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2002;12(3):174-8.
2002: Elena Papinutto; William G Dundon; Nea Pitulis; Roberto Battistutta; Cesare Montecucco; Giuseppe Zanotti
Structure of two iron-binding proteins from Bacillus anthracis.
The Journal of biological chemistry 2002;277(17):15093-8.
2002: Pasqualina Montemurro; Hiroaki Nishioka; William G Dundon; Marina de Bernard; Giuseppe Del Giudice; Rino Rappuoli; Cesare Montecucco
The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a potent stimulant of mast cells.
European journal of immunology 2002;32(3):671-6.
2002: William G Dundon; Hiroaki Nishioka; Alessandra Polenghi; Elena Papinutto; Giuseppe Zanotti; Pasqualina Montemurro; Giudice Giuseppe Del; Rino Rappuoli; Cesare Montecucco
The neutrophil-activating protein of Helicobacter pylori.
International journal of medical microbiology : IJMM 2002;291(6-7):545-50.
2002: Ornella Rossetto; Michela Seveso; Paola Caccin; Cesare Montecucco
Botulinum neurotoxins are metalloproteases specific for SNARE proteins involved in neuroexocytosis.
Current problems in dermatology 2002;30():117-25.
2002: Marina de Bernard; Monica Moschioni; A Habermann; G Griffiths; Cesare Montecucco
Cell vacuolization induced by Helicobacter pylori VacA cytotoxin does not depend on late endosomal SNAREs.
Cellular microbiology 2002;4(1):11-8.
2001: Francesco Tombola; Cristina Pagliaccia; Silvia Campello; John L Telford; Cesare Montecucco; Emanuele Papini; Mario Zoratti
How the loop and middle regions influence the properties of Helicobacter pylori VacA channels.
Biophysical journal 2001;81(6):3204-15.
2001: Michela Rigoni; Paola Caccin; Eric A Johnson; Cesare Montecucco; Ornella Rossetto
Site-directed mutagenesis identifies active-site residues of the light chain of botulinum neurotoxin type A.
Biochemical and biophysical research communications 2001;288(5):1231-7.
2001: Ornella Rossetto; Paola Caccin; Michela Rigoni; Fiorella Tonello; N Bortoletto; R C Stevens; Cesare Montecucco
Active-site mutagenesis of tetanus neurotoxin implicates TYR-375 and GLU-271 in metalloproteolytic activity.
Toxicon : official journal of the International Society on Toxinology 2001;39(8):1151-9.
2001: William G Dundon; H Nishioka; Cesare Montecucco; Pasqualina Montemurro; Rino Rappuoli; G Del Giudice
Problems assaying neutrophil activators.
Trends in microbiology 2001;9(7):314-5.
2001: William G Dundon; Alessandra Polenghi; G Del Guidice; Rino Rappuoli; Cesare Montecucco
Neutrophil-activating protein (HP-NAP) versus ferritin (Pfr): comparison of synthesis in Helicobacter pylori.
FEMS microbiology letters 2001;199(1):143-9.
2001: Pasqualina Montemurro; Giovanna Barbuti; William G Dundon; Giuseppe Del Giudice; Rino Rappuoli; Mario Colucci; Pietro De Rinaldis; Cesare Montecucco; Nicola Semeraro; Emanuele Papini
Helicobacter pylori neutrophil-activating protein stimulates tissue factor and plasminogen activator inhibitor-2 production by human blood mononuclear cells.
The Journal of infectious diseases 2001;183(7):1055-62.
2001: William G Dundon; Marina de Bernard; Cesare Montecucco
Virulence factors of Helicobacter pylori.
International journal of medical microbiology : IJMM 2001;290(8):647-58.
2001: Cesare Montecucco; Marina de Bernard; Emanuele Papini; Mario Zoratti
Helicobacter pylori vacuolating cytotoxin: cell intoxication and anion-specific channel activity.
Current topics in microbiology and immunology 2001;257():113-29.
2001: Ornella Rossetto; Michela Seveso; Paola Caccin; Giampietro Schiavo; Cesare Montecucco
Tetanus and botulinum neurotoxins: turning bad guys into good by research.
Toxicon : official journal of the International Society on Toxinology 2001;39(1):27-41.
2000: G Vitale; L Bernardi; G Napolitani; Michèle Mock; Cesare Montecucco
Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor.
The Biochemical journal 2000;352 Pt 3():739-45.
2000: L Bernardi; G Vitale; Cesare Montecucco; A Musacchio
Expression, crystallization and preliminary X-ray diffraction studies of recombinant Bacillus anthracis lethal factor.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 11):1449-51.
2000: R Pellizzari; C Guidi-Rontani; G Vitale; Michèle Mock; Cesare Montecucco
Lethal factor of Bacillus anthracis cleaves the N-terminus of MAPKKs: analysis of the intracellular consequences in macrophages.
International journal of medical microbiology : IJMM 2000;290(4-5):421-7.
2000: Cesare Montecucco; Ornella Rossetto
How do presynaptic PLA2 neurotoxins block nerve terminals?
Trends in biochemical sciences 2000;25(6):266-70.
2000: B Satin; Giuseppe Del Giudice; V Della Bianca; S Dusi; C Laudanna; Fiorella Tonello; D Kelleher; Rino Rappuoli; Cesare Montecucco; F Rossi
The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a protective antigen and a major virulence factor.
The Journal of experimental medicine 2000;191(9):1467-76.
2000: Ornella Rossetto; Marina de Bernard; R Pellizzari; G Vitale; Paola Caccin; Giampietro Schiavo; Cesare Montecucco
Bacterial toxins with intracellular protease activity.
Clinica chimica acta; international journal of clinical chemistry 2000;291(2):189-99.
2000: Marina de Bernard; Monica Moschioni; G Napolitani; Rino Rappuoli; Cesare Montecucco
The VacA toxin of Helicobacter pylori identifies a new intermediate filament-interacting protein.
The EMBO journal 2000;19(1):48-56.
1999: Philip Washbourne; N Bortoletto; Margaret E Graham; Michael Wilson; Robert D Burgoyne; Cesare Montecucco
Botulinum neurotoxin E-insensitive mutants of SNAP-25 fail to bind VAMP but support exocytosis.
Journal of neurochemistry 1999;73(6):2424-33.
1999: R Pellizzari; C Guidi-Rontani; G Vitale; Michèle Mock; Cesare Montecucco
Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNgamma-induced release of NO and TNFalpha.
FEBS letters 1999;462(1-2):199-204.
1999: Francesco Tombola; F Oregna; S Brutsche; Ildikò Szabò; Giuseppe Del Giudice; R Rappuoli; Cesare Montecucco; Emanuele Papini; Mario Zoratti
Inhibition of the vacuolating and anion channel activities of the VacA toxin of Helicobacter pylori.
FEBS letters 1999;460(2):221-5.
1999: Ildikò Szabò; S Brutsche; Francesco Tombola; Monica Moschioni; B Satin; John L Telford; Rino Rappuoli; Cesare Montecucco; Emanuele Papini; Mario Zoratti
Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity.
The EMBO journal 1999;18(20):5517-27.
1999: Fiorella Tonello; William G Dundon; B Satin; M Molinari; Giuseppe Tognon; G Grandi; Giuseppe Del Giudice; Rino Rappuoli; Cesare Montecucco
The Helicobacter pylori neutrophil-activating protein is an iron-binding protein with dodecameric structure.
Molecular microbiology 1999;34(2):238-46.
1999: Claudia Verderio; Silvia Coco; Alberto Bacci; Ornella Rossetto; Pietro De Camilli; Cesare Montecucco; Michela Matteoli
Tetanus toxin blocks the exocytosis of synaptic vesicles clustered at synapses but not of synaptic vesicles in isolated axons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(16):6723-32.
1999: Vladimir Pelicic; Reyrat Jean-Marc; Leonardo Sartori; Cristina Pagliaccia; Rino Rappuoli; John L Telford; Cesare Montecucco; Emanuele Papini
Helicobacter pylori VacA cytotoxin associated with the bacteria increases epithelial permeability independently of its vacuolating activity.
Microbiology (Reading, England) 1999;145 ( Pt 8)():2043-50.
1999: Claudia Verderio; Silvia Coco; Ornella Rossetto; Cesare Montecucco; Michela Matteoli
Internalization and proteolytic action of botulinum toxins in CNS neurons and astrocytes.
Journal of neurochemistry 1999;73(1):372-9.
1999: Cesare Montecucco; Emanuele Papini; Marina de Bernard; Mario Zoratti
Molecular and cellular activities of Helicobacter pylori pathogenic factors.
FEBS letters 1999;452(1-2):16-21.
1999: Fiorella Tonello; R Pellizzari; S Pasqualato; G Grandi; Evaristo Peggion; Cesare Montecucco
Recombinant and truncated tetanus neurotoxin light chain: cloning, expression, purification, and proteolytic activity.
Protein expression and purification 1999;15(2):221-7.
1999: Francesco Tombola; C Carlesso; Ildikò Szabò; Marina de Bernard; Reyrat Jean-Marc; John L Telford; R Rappuoli; Cesare Montecucco; Emanuele Papini; Mario Zoratti
Helicobacter pylori vacuolating toxin forms anion-selective channels in planar lipid bilayers: possible implications for the mechanism of cellular vacuolation.
Biophysical journal 1999;76(3):1401-9.
1999: R Pellizzari; Ornella Rossetto; Giampietro Schiavo; Cesare Montecucco
Tetanus and botulinum neurotoxins: mechanism of action and therapeutic uses.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1999;354(1381):259-68.
1998: R Pellizzari; Ornella Rossetto; Philip Washbourne; Fiorella Tonello; P L Nicotera; Cesare Montecucco
In vitro biological activity and toxicity of tetanus and botulinum neurotoxins.
Toxicology letters 1998;102-103():191-7.
1998: Marina de Bernard; Daniela Burroni; Emanuele Papini; Rino Rappuoli; J Telford; Cesare Montecucco
Identification of the Helicobacter pylori VacA toxin domain active in the cell cytosol.
Infection and immunity 1998;66(12):6014-6.
1998: Marina de Bernard; Monica Moschioni; Emanuele Papini; J Telford; Rino Rappuoli; Cesare Montecucco
Cell vacuolization induced by Helicobacter pylori VacA toxin: cell line sensitivity and quantitative estimation.
Toxicology letters 1998;99(2):109-15.
1998: Marina de Bernard; Monica Moschioni; Emanuele Papini; John L Telford; Rino Rappuoli; Cesare Montecucco
TPA and butyrate increase cell sensitivity to the vacuolating toxin of Helicobacter pylori.
FEBS letters 1998;436(2):218-22.
1998: Emanuele Papini; B Satin; Nathalie Norais; Marina de Bernard; John L Telford; Rino Rappuoli; Cesare Montecucco
Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin.
The Journal of clinical investigation 1998;102(4):813-20.
1998: G Vitale; R Pellizzari; C Recchi; G Napolitani; Michèle Mock; Cesare Montecucco
Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages.
Biochemical and biophysical research communications 1998;248(3):706-11.
1998: M Molinari; C Galli; Marina de Bernard; Nathalie Norais; J M Ruysschaert; Rino Rappuoli; Cesare Montecucco
The acid activation of Helicobacter pylori toxin VacA: structural and membrane binding studies.
Biochemical and biophysical research communications 1998;248(2):334-40.
1998: Philip Washbourne; R Pellizzari; Ornella Rossetto; N Bortoletto; Valeria Tugnoli; Domenico De Grandis; Roberto Eleopra; Cesare Montecucco
On the action of botulinum neurotoxins A and E at cholinergic terminals.
Journal of physiology, Paris 1998;92(2):135-9.
1998: M Molinari; M Salio; C Galli; Nathalie Norais; Rino Rappuoli; A Lanzavecchia; Cesare Montecucco
Selective inhibition of Ii-dependent antigen presentation by Helicobacter pylori toxin VacA.
The Journal of experimental medicine 1998;187(1):135-40.
1998: Emanuele Papini; B Satin; Marina de Bernard; M Molinari; B Aricò; C Galli; J R Telford; Rino Rappuoli; Cesare Montecucco
Action site and cellular effects of cytotoxin VacA produced by Helicobacter pylori.
Folia microbiologica 1998;43(3):279-84.
1997: Philip Washbourne; R Pellizzari; G Baldini; Michael Wilson; Cesare Montecucco
Botulinum neurotoxin types A and E require the SNARE motif in SNAP-25 for proteolysis.
FEBS letters 1997;418(1-2):1-5.
1997: Marina de Bernard; B Arico; Emanuele Papini; R Rizzuto; G Grandi; Rino Rappuoli; Cesare Montecucco
Helicobacter pylori toxin VacA induces vacuole formation by acting in the cell cytosol.
Molecular microbiology 1997;26(4):665-74.
1997: M Molinari; C Galli; Nathalie Norais; John L Telford; Rino Rappuoli; J P Luzio; Cesare Montecucco
Vacuoles induced by Helicobacter pylori toxin contain both late endosomal and lysosomal markers.
The Journal of biological chemistry 1997;272(40):25339-44.
1997: B Satin; Nathalie Norais; J Telford; Rino Rappuoli; M Murgia; Cesare Montecucco; Emanuele Papini
Effect of helicobacter pylori vacuolating toxin on maturation and extracellular release of procathepsin D and on epidermal growth factor degradation.
The Journal of biological chemistry 1997;272(40):25022-8.
1997: R Pellizzari; S Mason; C C Shone; Cesare Montecucco
The interaction of synaptic vesicle-associated membrane protein/synaptobrevin with botulinum neurotoxins D and F.
FEBS letters 1997;409(3):339-42.
1997: Fiorella Tonello; Giampietro Schiavo; Cesare Montecucco
Metal substitution of tetanus neurotoxin.
The Biochemical journal 1997;322 ( Pt 2)():507-10.
1997: Emanuele Papini; B Satin; C Bucci; Marina de Bernard; John L Telford; Roberto Manetti; Rino Rappuoli; M Zerial; Cesare Montecucco
The small GTP binding protein rab7 is essential for cellular vacuolation induced by Helicobacter pylori cytotoxin.
The EMBO journal 1997;16(1):15-24.
1996: Cesare Montecucco; E Papini; Giampietro Schiavo
Bacterial protein toxins and cell vesicle trafficking.
Experientia 1996;52(12):1026-32.
1996: A Menard; E Papini; Michèle Mock; Cesare Montecucco
The cytotoxic activity of Bacillus anthracis lethal factor is inhibited by leukotriene A4 hydrolase and metallopeptidase inhibitors.
The Biochemical journal 1996;320 ( Pt 2)():687-91.
1996: Michela Matteoli; Claudia Verderio; Ornella Rossetto; N Iezzi; Silvia Coco; Giampietro Schiavo; Cesare Montecucco
Synaptic vesicle endocytosis mediates the entry of tetanus neurotoxin into hippocampal neurons.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(23):13310-5.
1996: Cesare Montecucco; Giampietro Schiavo; Valeria Tugnoli; Domenico De Grandis
Botulinum neurotoxins: mechanism of action and therapeutic applications.
Molecular medicine today 1996;2(10):418-24.
1996: R Pellizzari; Ornella Rossetto; L Lozzi; S Giovedi'; E Johnson; Clifford C Shone; Cesare Montecucco
Structural determinants of the specificity for synaptic vesicle-associated membrane protein/synaptobrevin of tetanus and botulinum type B and G neurotoxins.
The Journal of biological chemistry 1996;271(34):20353-8.
1996: Emanuele Papini; Enrico Gottardi; B Satin; Marina de Bernard; P Massari; J Telford; Rino Rappuoli; S B Sato; Cesare Montecucco
The vacuolar ATPase proton pump is present on intracellular vacuoles induced by Helicobacter pylori.
Journal of medical microbiology 1996;45(2):84-9.
1996: A Ménard; K Altendorf; D Breves; Michèle Mock; Cesare Montecucco
The vacuolar ATPase proton pump is required for the cytotoxicity of Bacillus anthracis lethal toxin.
FEBS letters 1996;386(2-3):161-4.
1996: Silvia Morante; L Furenlid; Giampietro Schiavo; Fiorella Tonello; R Zwilling; Cesare Montecucco
X-ray absorption spectroscopy study of zinc coordination in tetanus neurotoxin, astacin, alkaline protease and thermolysin.
European journal of biochemistry / FEBS 1996;235(3):606-12.
1996: Fiorella Tonello; Silvia Morante; Ornella Rossetto; Giampietro Schiavo; Cesare Montecucco
Tetanus and botulism neurotoxins: a novel group of zinc-endopeptidases.
Advances in experimental medicine and biology 1996;389():251-60.
1996: Cesare Montecucco; Giampietro Schiavo; Ornella Rossetto
The mechanism of action of tetanus and botulinum neurotoxins.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1996;18():342-54.
1996: Ornella Rossetto; Luisa Gorza; Giampietro Schiavo; N Schiavo; R H Scheller; Cesare Montecucco
VAMP/synaptobrevin isoforms 1 and 2 are widely and differentially expressed in nonneuronal tissues.
The Journal of cell biology 1996;132(1-2):167-79.
1995: G Moll; Emanuele Papini; Raffaele Colonna; Daniela Burroni; J Telford; Rino Rappuoli; Cesare Montecucco
Lipid interaction of the 37-kDa and 58-kDa fragments of the Helicobacter pylori cytotoxin.
European journal of biochemistry / FEBS 1995;234(3):947-52.
1995: Cesare Montecucco; Giampietro Schiavo
Structure and function of tetanus and botulinum neurotoxins.
Quarterly reviews of biophysics 1995;28(4):423-72.
1995: Roberto Manetti; P Massari; Daniela Burroni; Marina de Bernard; A Marchini; R Olivieri; Emanuele Papini; Cesare Montecucco; Rino Rappuoli; John L Telford
Helicobacter pylori cytotoxin: importance of native conformation for induction of neutralizing antibodies.
Infection and immunity 1995;63(11):4476-80.
1995: Marina de Bernard; Emanuele Papini; V de Filippis; Enrico Gottardi; J Telford; Roberto Manetti; A Fontana; Rino Rappuoli; Cesare Montecucco
Low pH activates the vacuolating toxin of Helicobacter pylori, which becomes acid and pepsin resistant.
The Journal of biological chemistry 1995;270(41):23937-40.
1995: Giampietro Schiavo; Clifford C Shone; M K Bennett; R H Scheller; Cesare Montecucco
Botulinum neurotoxin type C cleaves a single Lys-Ala bond within the carboxyl-terminal region of syntaxins.
The Journal of biological chemistry 1995;270(18):10566-70.
1995: V De Filippis; L Vangelista; Giampietro Schiavo; Fiorella Tonello; Cesare Montecucco
Structural studies on the zinc-endopeptidase light chain of tetanus neurotoxin.
European journal of biochemistry / FEBS 1995;229(1):61-9.
1995: Philip Washbourne; Giampietro Schiavo; Cesare Montecucco
Vesicle-associated membrane protein-2 (synaptobrevin-2) forms a complex with synaptophysin.
The Biochemical journal 1995;305 ( Pt 3)():721-4.
1995: Giampietro Schiavo; Ornella Rossetto; Fiorella Tonello; Cesare Montecucco
Intracellular targets and metalloprotease activity of tetanus and botulism neurotoxins.
Current topics in microbiology and immunology 1995;195():257-74.
1995: Giampietro Schiavo; Cesare Montecucco
Tetanus and botulism neurotoxins: isolation and assay.
Methods in enzymology 1995;248():643-52.
1995: Ornella Rossetto; F Deloye; Bernard Poulain; R Pellizzari; Giampietro Schiavo; Cesare Montecucco
The metallo-proteinase activity of tetanus and botulism neurotoxins.
Journal of physiology, Paris 1995;89(1):43-50.
1994: Ornella Rossetto; Giampietro Schiavo; Cesare Montecucco; Bernard Poulain; F Deloye; L Lozzi; Clifford C Shone
SNARE motif and neurotoxins.
Nature 1994;372(6505):415-6.
1994: Emanuele Papini; Marina de Bernard; E Milia; M Bugnoli; M Zerial; Rino Rappuoli; Cesare Montecucco
Cellular vacuoles induced by Helicobacter pylori originate from late endosomal compartments.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(21):9720-4.
1994: Giampietro Schiavo; C Malizio; W S Trimble; P Polverino de Laureto; Gabriella Milan; H Sugiyama; E A Johnson; Cesare Montecucco
Botulinum G neurotoxin cleaves VAMP/synaptobrevin at a single Ala-Ala peptide bond.
The Journal of biological chemistry 1994;269(32):20213-6.
1994: Giampietro Schiavo; Ornella Rossetto; Cesare Montecucco
Clostridial neurotoxins as tools to investigate the molecular events of neurotransmitter release.
Seminars in cell biology 1994;5(4):221-9.
1994: Cesare Montecucco; Giampietro Schiavo
Mechanism of action of tetanus and botulinum neurotoxins.
Molecular microbiology 1994;13(1):1-8.
1994: Cesare Montecucco; Emanuele Papini; Giampietro Schiavo
Bacterial protein toxins penetrate cells via a four-step mechanism.
FEBS letters 1994;346(1):92-8.
1994: Giampietro Schiavo; Ornella Rossetto; F Benfenati; Bernard Poulain; Cesare Montecucco
Tetanus and botulinum neurotoxins are zinc proteases specific for components of the neuroexocytosis apparatus.
Annals of the New York Academy of Sciences 1994;710():65-75.
1993: Giampietro Schiavo; A Santucci; B R Dasgupta; P P Mehta; J Jontes; F Benfenati; Michael Wilson; Cesare Montecucco
Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds.
FEBS letters 1993;335(1):99-103.
1993: Giampietro Schiavo; Ornella Rossetto; Stefan Catsicas; P Polverino de Laureto; B R DasGupta; F Benfenati; Cesare Montecucco
Identification of the nerve terminal targets of botulinum neurotoxin serotypes A, D, and E.
The Journal of biological chemistry 1993;268(32):23784-7.
1993: Emanuele Papini; Marina de Bernard; M Bugnoli; E Milia; Rino Rappuoli; Cesare Montecucco
Cell vacuolization induced by Helicobacter pylori: inhibition by bafilomycins A1, B1, C1 and D.
FEMS microbiology letters 1993;113(2):155-9.
1993: Bernard Poulain; Ornella Rossetto; F Deloye; Giampietro Schiavo; L Tauc; Cesare Montecucco
Antibodies against rat brain vesicle-associated membrane protein (synaptobrevin) prevent inhibition of acetylcholine release by tetanus toxin or botulinum neurotoxin type B.
Journal of neurochemistry 1993;61(3):1175-8.
1993: Cesare Montecucco; Giampietro Schiavo
Tetanus and botulism neurotoxins: a new group of zinc proteases.
Trends in biochemical sciences 1993;18(9):324-7.
1993: Giampietro Schiavo; Bernard Poulain; F Benfenati; B R DasGupta; Cesare Montecucco
Novel targets and catalytic activities of bacterial protein toxins.
Trends in microbiology 1993;1(5):170-4.
1993: Giampietro Schiavo; Clifford C Shone; Ornella Rossetto; F C Alexander; Cesare Montecucco
Botulinum neurotoxin serotype F is a zinc endopeptidase specific for VAMP/synaptobrevin.
The Journal of biological chemistry 1993;268(16):11516-9.
1993: Emanuele Papini; G Cabrini; Cesare Montecucco
The sensitivity of cystic fibrosis cells to diphtheria toxin.
Toxicon : official journal of the International Society on Toxinology 1993;31(3):359-62.
1993: Emanuele Papini; Rino Rappuoli; Marta Murgia; Cesare Montecucco
Cell penetration of diphtheria toxin. Reduction of the interchain disulfide bridge is the rate-limiting step of translocation in the cytosol.
The Journal of biological chemistry 1993;268(3):1567-74.
1993: Emanuele Papini; M Bugnoli; Marina de Bernard; N Figura; Rino Rappuoli; Cesare Montecucco
Bafilomycin A1 inhibits Helicobacter pylori-induced vacuolization of HeLa cells.
Molecular microbiology 1993;7(2):323-7.
1992: Giampietro Schiavo; Ornella Rossetto; A Santucci; B R DasGupta; Cesare Montecucco
Botulinum neurotoxins are zinc proteins.
The Journal of biological chemistry 1992;267(33):23479-83.
1992: Giampietro Schiavo; F Benfenati; Bernard Poulain; Ornella Rossetto; P Polverino de Laureto; B R DasGupta; Cesare Montecucco
Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin.
Nature 1992;359(6398):832-5.
1992: Giampietro Schiavo; Bernard Poulain; Ornella Rossetto; F Benfenati; L Tauc; Cesare Montecucco
Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc.
The EMBO journal 1992;11(10):3577-83.
1992: E Calappi; Massimo Masserini; Giampietro Schiavo; Cesare Montecucco; Guido Tettamanti
Lipid interaction of tetanus neurotoxin. A calorimetric and fluorescence spectroscopy study.
FEBS letters 1992;309(2):107-10.
1992: Cesare Montecucco; Emanuele Papini; Giampietro Schiavo; E Padovan; Ornella Rossetto
Ion channel and membrane translocation of diphtheria toxin.
FEMS microbiology immunology 1992;5(1-3):101-11.
1992: Ornella Rossetto; Giampietro Schiavo; P Polverino de Laureto; S Fabbiani; Cesare Montecucco
Surface topography of histidine residues of tetanus toxin probed by immobilized-metal-ion affinity chromatography.
The Biochemical journal 1992;285 ( Pt 1)():9-12.
1991: Emanuele Papini; A Santucci; Giampietro Schiavo; M Domenighini; P Neri; Rino Rappuoli; Cesare Montecucco
Tyrosine 65 is photolabeled by 8-azidoadenine and 8-azidoadenosine at the NAD binding site of diphtheria toxin.
The Journal of biological chemistry 1991;266(4):2494-8.
1991: E Padovan; Emanuele Papini; Rino Rappuoli; Cesare Montecucco
Determination of diphtheria toxin neutralizing antibody titers with a cell protein synthesis inhibition assay.
Medical microbiology and immunology 1991;180(1):29-35.
1990: Giampietro Schiavo; Emanuele Papini; G Genna; Cesare Montecucco
An intact interchain disulfide bond is required for the neurotoxicity of tetanus toxin.
Infection and immunity 1990;58(12):4136-41.
1990: Emanuele Papini; Giampietro Schiavo; Rino Rappuoli; Cesare Montecucco
Histidine-21 is involved in diphtheria toxin NAD+ binding.
Toxicon : official journal of the International Society on Toxinology 1990;28(6):631-5.
1990: Giampietro Schiavo; P Boquet; B R Dasgupta; Cesare Montecucco
Membrane interactions of tetanus and botulinum neurotoxins: a photolabelling study with photoactivatable phospholipids.
Journal de physiologie 1990;84(2):180-7.
1989: Emanuele Papini; Giampietro Schiavo; D Sandoná; Rino Rappuoli; Cesare Montecucco
Histidine 21 is at the NAD+ binding site of diphtheria toxin.
The Journal of biological chemistry 1989;264(21):12385-8.
1989: Cesare Montecucco; Giampietro Schiavo; B R Dasgupta
Effect of pH on the interaction of botulinum neurotoxins A, B and E with liposomes.
The Biochemical journal 1989;259(1):47-53.
1988: Emanuele Papini; D Sandoná; Rino Rappuoli; Cesare Montecucco
On the membrane translocation of diphtheria toxin: at low pH the toxin induces ion channels on cells.
The EMBO journal 1988;7(11):3353-9.
1987: Emanuele Papini; Giampietro Schiavo; M Tomasi; M Colombatti; Rino Rappuoli; Cesare Montecucco
Lipid interaction of diphtheria toxin and mutants with altered fragment B. 2. Hydrophobic photolabelling and cell intoxication.
European journal of biochemistry / FEBS 1987;169(3):637-44.
1987: Emanuele Papini; Raffaele Colonna; Federico Cusinato; Cesare Montecucco; M Tomasi; Rino Rappuoli
Lipid interaction of diphtheria toxin and mutants with altered fragment B. 1. Liposome aggregation and fusion.
European journal of biochemistry / FEBS 1987;169(3):629-35.
1987: Emanuele Papini; Raffaele Colonna; Giampietro Schiavo; Federico Cusinato; M Tomasi; Rino Rappuoli; Cesare Montecucco
Diphtheria toxin and its mutant crm 197 differ in their interaction with lipids.
FEBS letters 1987;215(1):73-8.