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Marylyn Ritchie

Research Profile

Physiology

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Matthew T Oetjens; Jill Pulley; Nicole A Restrepo; Danielle M Richardson; Marylyn Ritchie; Dan M Roden; Russell A Wilke; Joshua C Denny; Holli H Dilks; Niloufar B Gillani; Daniel R Masys; Melissa A Basford; Erica Bowton; Dana C Crawford
Assessment of a pharmacogenomic marker panel in a polypharmacy population identified from electronic medical records.
Kylee L Spencer; Lynne Wilkens; Alicia Young; Kathleen Brennan; Steven Buyske; Christopher S Carlson; Cara L Carty; Iona Cheng; Lindsay Fernández-Rhodes; Nora Franceschini; Christopher A Haiman; Lucia A Hindorff; Jennifer Malinowski; Tara C Matise; Amy Park; Aleksandar Rajkovic; Marylyn Ritchie; Dana C Crawford
Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study.
Emily R Holzinger; Ronald M Krauss; Marisa W Medina; Scott M Dudek; Alex T Frase; Marylyn Ritchie
ATHENA: a tool for meta-dimensional analysis applied to genotypes and gene expression data to predict HDL cholesterol levels.

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All Publications

2013: Matthew T Oetjens; Jill Pulley; Nicole A Restrepo; Danielle M Richardson; Marylyn Ritchie; Dan M Roden; Russell A Wilke; Joshua C Denny; Holli H Dilks; Niloufar B Gillani; Daniel R Masys; Melissa A Basford; Erica Bowton; Dana C Crawford
Assessment of a pharmacogenomic marker panel in a polypharmacy population identified from electronic medical records.
Pharmacogenomics 2013;14(7):735-44.
2013: Kylee L Spencer; Lynne Wilkens; Alicia Young; Kathleen Brennan; Steven Buyske; Christopher S Carlson; Cara L Carty; Iona Cheng; Lindsay Fernández-Rhodes; Nora Franceschini; Christopher A Haiman; Lucia A Hindorff; Jennifer Malinowski; Tara C Matise; Amy Park; Aleksandar Rajkovic; Marylyn Ritchie; Dana C Crawford
Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study.
PloS one 2013;8(2):e55258.
2013: Emily R Holzinger; Ronald M Krauss; Marisa W Medina; Scott M Dudek; Alex T Frase; Marylyn Ritchie
ATHENA: a tool for meta-dimensional analysis applied to genotypes and gene expression data to predict HDL cholesterol levels.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2013;():385-96.
2013: William S Bush; Melissa A Basford; Jonathan Boston; Kristin Brown-Gentry; Logan Dumitrescu; Robert Goodloe; Bob McClellan; Sarah A Pendergrass; Marylyn Ritchie; Kylee L Spencer; Eric Torstenson; Sarah Wilson; Dana C Crawford
Enabling high-throughput genotype-phenotype associations in the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) project as part of the Population Architecture using Genomics and Epidemiology (PAGE) study.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2013;():373-84.
2013: Carrie B Moore; Sarah A Pendergrass; Alex T Frase; John R Wallace; Marylyn Ritchie
Using BioBin to explore rare variant population stratification.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2013;():332-43.
2013: Dana C Crawford; Holli H Dilks; Niloufar B Gillani; Robert Goodloe; Marylyn Ritchie; Jamie Roberson; Sarah Wilson; Kristin Brown-Gentry; William S Bush
Characterization of the Metabochip in diverse populations from the International HapMap Project in the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) project.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2013;():188-99.
2013: Sarah A Pendergrass; Shefali S Verma; John Wallace; Carol Waudby; Richard Berg; Scott M Dudek; Emily R Holzinger; Wayne Huggins; Terrie Kitchner; Catherine A McCarty; Carrie B Moore; Marylyn Ritchie
Next-generation analysis of cataracts: determining knowledge driven gene-gene interactions using Biofilter, and gene-environment interactions using the PhenX Toolkit.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2013;():147-58.
2012: Jonathan S Schildcrout; R A Wilke; H Xu; M A Basford; E Bowton; J D Cowan; Dana C Crawford; Joshua C Denny; William Gregg; Daniel R Masys; Josh F Peterson; Jill Pulley; A H Ramirez; Marylyn Ritchie; Dan Mark Roden
Optimizing drug outcomes through pharmacogenetics: a case for preemptive genotyping.
Clinical pharmacology and therapeutics 2012;92(2):235-42.
2012: Andrea H Ramirez; Marylyn Ritchie; Dan M Roden; Jonathan S Schildcrout; Yaping Shi; Peter Speltz; Hua Xu; Raquel Zink; Rebecca L Zuvich; Melissa A Basford; Erica Bowton; James Cowan; Dana C Crawford; Jessica T Delaney; Min Jiang; Daniel R Masys; Matthew T Oetjens; Jill Pulley; Joshua C Denny
Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record.
Pharmacogenomics 2012;13(4):407-18.
2012: Carrie C Buchanan; William S Bush; Eric S Torstenson; Marylyn Ritchie
A comparison of cataloged variation between International HapMap Consortium and 1000 Genomes Project data.
Journal of the American Medical Informatics Association : JAMIA 2012;19(2):289-94.
2012: J T Delaney; M A Basford; E Bowton; J H Cleator; Dana C Crawford; E Jahangir; Daniel R Masys; M Oetjens; Jill Pulley; A H Ramirez; Marylyn Ritchie; Dan Mark Roden; Jonathan S Schildcrout; Y Shi; H Xu; R Zink; Joshua C Denny
Predicting clopidogrel response using DNA samples linked to an electronic health record.
Clinical pharmacology and therapeutics 2012;91(2):257-63.
2011: Rebecca L Zuvich; Stephen D Turner; Russell A Wilke; Loren L Armstrong; Suzette J Bielinski; Yuki Bradford; Christopher S Carlson; Dana C Crawford; Andrew Thomas Crenshaw; Mariza de Andrade; Kimberly F Doheny; Jonathan L Haines; M Geoffrey Hayes; Gail P Jarvik; Lan Jiang; Iftikhar J Kullo; Rongling Li; Hua Ling; Teri A Manolio; Martha E Matsumoto; Catherine A McCarty; Andrew N McDavid; Daniel B Mirel; Lana M Olson; Justin E Paschall; Elizabeth W Pugh; Luke V Rasmussen; Laura J Rasmussen-Torvik; Marylyn Ritchie
Pitfalls of merging GWAS data: lessons learned in the eMERGE network and quality control procedures to maintain high data quality.
Genetic epidemiology 2011;35(8):887-98.
2011: Hua Xu; Melissa A Basford; Erica A Bowton; James D Cowan; Dana C Crawford; Janina M Jeff; Min Jiang; Daniel R Masys; Matt Oetjens; Jill Pulley; Andrea H Ramirez; Marylyn Ritchie; Dan Mark Roden; Xiaoming Wang; Joshua C Denny
Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin.
Journal of the American Medical Informatics Association : JAMIA 2011;18(4):387-91.
2011: S A Pendergrass; A P Reiner; E S Torstenson; R Wallace; L R Wilkens; J L Ambite; C L Avery; K Brown-Gentry; S Buyske; C Cai; Dana C Crawford; S M Dudek; M D Fesinmeyer; C Haiman; G Heiss; L A Hindorff; C-N Hsu; R D Jackson; C Kooperberg; L Le Marchand; Y Lin; T C Matise; K Monroe; L Moreland; Marylyn Ritchie
The use of phenome-wide association studies (PheWAS) for exploration of novel genotype-phenotype relationships and pleiotropy discovery.
Genetic epidemiology 2011;35(5):410-22.
2011: Jovanny Zabaleta; Maria C Camargo; Marylyn Ritchie; Maria B Piazuelo; Rosa A Sierra; Stephen D Turner; Alberto Delgado; Elizabeth T H Fontham; Barbara G Schneider; Pelayo Correa; Augusto C Ochoa
Association of haplotypes of inflammation-related genes with gastric preneoplastic lesions in African Americans and Caucasians.
International journal of cancer. Journal international du cancer 2011;128(3):668-75.
2011: Todd Hulgan; Richard Haubrich; Sharon A Riddler; Pablo Tebas; Marylyn Ritchie; Grace A McComsey; David W Haas; Jeffrey A Canter
European mitochondrial DNA haplogroups and metabolic changes during antiretroviral therapy in AIDS Clinical Trials Group Study A5142.
AIDS (London, England) 2011;25(1):37-47.
2011: Stephen D Turner; Richard L Berg; James G Linneman; Peggy L Peissig; Dana C Crawford; Joshua C Denny; Dan Mark Roden; Catherine A McCarty; Marylyn Ritchie; Russell A Wilke
Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks.
PloS one 2011;6(5):e19586.
2011: Benjamin J Grady; Eric S Torstenson; Marylyn Ritchie
The effects of linkage disequilibrium in large scale SNP datasets for MDR.
BioData mining 2011;4():11.
2011: Thorsten Lehr; Jing Yuan; Dirk Zeumer; Supriya Jayadev; Marylyn Ritchie
Rule based classifier for the analysis of gene-gene and gene-environment interactions in genetic association studies.
BioData mining 2011;4():4.
2011: Catherine A McCarty; Rex Chisholm; Christopher G Chute; Iftikhar J Kullo; Gail P Jarvik; Eric B Larson; Rongling Li; Daniel R Masys; Marylyn Ritchie; Dan Mark Roden; Jeffery P Struewing; Wendy A Wolf
The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies.
BMC medical genomics 2011;4():13.
2011: Stephen Turner; Loren L Armstrong; Yuki Bradford; Christopher S Carlson; Dana C Crawford; Andrew Thomas Crenshaw; Mariza de Andrade; Kimberly F Doheny; Jonathan L Haines; Geoffrey Hayes; Gail P Jarvik; Lan Jiang; Iftikhar J Kullo; Rongling Li; Hua Ling; Teri A Manolio; Martha Matsumoto; Catherine A McCarty; Andrew N McDavid; Daniel B Mirel; Justin E Paschall; Elizabeth W Pugh; Luke V Rasmussen; Russell A Wilke; Rebecca L Zuvich; Marylyn Ritchie
Quality control procedures for genome-wide association studies.
Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.] 2011;Chapter 1():Unit1.19.
2011: Marylyn Ritchie
Using biological knowledge to uncover the mystery in the search for epistasis in genome-wide association studies.
Annals of human genetics 2011;75(1):172-82.
2011: Tom Cattaert; M Luz Calle; Scott M Dudek; Jestinah M Mahachie John; François Van Lishout; Victor Urrea; Marylyn Ritchie; Kristel van Steen
Model-based multifactor dimensionality reduction for detecting epistasis in case-control data in the presence of noise.
Annals of human genetics 2011;75(1):78-89.
2011: Sarah Pendergrass; Scott M Dudek; Dan Mark Roden; Dana C Crawford; Marylyn Ritchie
Visual integration of results from a large DNA biobank (BioVU) using synthesis-view.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2011;():265-75.
2011: Benjamin J Grady; Eric S Torstenson; Paul J McLaren; Paul I W de Bakker; David W Haas; Gregory K Robbins; Roy M Gulick; Richard Haubrich; Heather Ribaudo; Marylyn Ritchie
Use of biological knowledge to inform the analysis of gene-gene interactions involved in modulating virologic failure with efavirenz-containing treatment regimens in art-naïve ACTG clinical trials participants.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2011;():253-64.
2010: Joshua C Denny; Marylyn Ritchie; Dana C Crawford; Jonathan S Schildcrout; Andrea H Ramirez; Jill Pulley; Melissa A Basford; Daniel R Masys; Jonathan L Haines; Dan Mark Roden
Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science.
Circulation 2010;122(20):2016-21.
2010: Logan Dumitrescu; Marylyn Ritchie; Kristin Brown-Gentry; Jill Pulley; Melissa Basford; Joshua C Denny; Jorge R Oksenberg; Dan Mark Roden; Jonathan L Haines; Dana C Crawford
Assessing the accuracy of observer-reported ancestry in a biorepository linked to electronic medical records.
Genetics in medicine : official journal of the American College of Medical Genetics 2010;12(10):648-50.
2010: Heather J Ribaudo; Huan Liu; Matthias Schwab; Elke Schaeffeler; Michel Eichelbaum; Alison A Motsinger-Reif; Marylyn Ritchie; Ulrich M Zanger; Edward P Acosta; Gene D Morse; Roy M Gulick; Gregory K Robbins; David Clifford; David W Haas
Effect of CYP2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response: an AIDS Clinical Trials Group study.
The Journal of infectious diseases 2010;202(5):717-22.
2010: Jeffrey A Canter; Gregory K Robbins; Doug Selph; David B Clifford; Asha R Kallianpur; Robert Shafer; Shawn Levy; Deborah G Murdock; Marylyn Ritchie; David W Haas; Todd Hulgan
African mitochondrial DNA subhaplogroups and peripheral neuropathy during antiretroviral therapy.
The Journal of infectious diseases 2010;201(11):1703-7.
2010: Joshua C Denny; Marylyn Ritchie; Melissa A Basford; Jill Pulley; Lisa Bastarache; Kristin Brown-Gentry; Deede Wang; Daniel R Masys; Dan Mark Roden; Dana C Crawford
PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations.
Bioinformatics (Oxford, England) 2010;26(9):1205-10.
2010: Marylyn Ritchie; Joshua C Denny; Dana C Crawford; Andrea H Ramirez; Justin B Weiner; Jill Pulley; Melissa A Basford; Kristin Brown-Gentry; Jeffrey R Balser; Daniel R Masys; Jonathan L Haines; Dan Mark Roden
Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record.
American journal of human genetics 2010;86(4):560-72.
2010: William S Bush; Scott M Dudek; Marylyn Ritchie
Visualizing SNP statistics in the context of linkage disequilibrium using LD-Plus.
Bioinformatics (Oxford, England) 2010;26(4):578-9.
2010: Todd L Edwards; Eric Torstensen; Scott Dudek; Eden R Martin; Marylyn Ritchie
A cross-validation procedure for general pedigrees and matched odds ratio fitness metric implemented for the multifactor dimensionality reduction pedigree disequilibrium test.
Genetic epidemiology 2010;34(2):194-9.
2010: Sarah A Pendergrass; Scott M Dudek; Dana C Crawford; Marylyn Ritchie
Synthesis-View: visualization and interpretation of SNP association results for multi-cohort, multi-phenotype data and meta-analysis.
BioData mining 2010;3():10.
2010: Marylyn Ritchie; William S Bush
Genome simulation approaches for synthesizing in silico datasets for human genomics.
Advances in genetics 2010;72():1-24.
2010: Stephen D Turner; Scott M Dudek; Marylyn Ritchie
ATHENA: A knowledge-based hybrid backpropagation-grammatical evolution neural network algorithm for discovering epistasis among quantitative trait Loci.
BioData mining 2010;3(1):5.
2010: Tom Cattaert; Víctor Urrea; Adam C Naj; Lizzy De Lobel; Vanessa De Wit; Mao Fu; Jestinah M Mahachie John; Haiqing Shen; M Luz Calle; Marylyn Ritchie; Todd L Edwards; Kristel Van Steen
FAM-MDR: a flexible family-based multifactor dimensionality reduction technique to detect epistasis using related individuals.
PloS one 2010;5(4):e10304.
2010: Russell A Wilke; Richard L Berg; James G Linneman; Peggy Peissig; Justin Starren; Marylyn Ritchie; Catherine A McCarty
Quantification of the clinical modifiers impacting high-density lipoprotein cholesterol in the community: Personalized Medicine Research Project.
Preventive cardiology 2010;13(2):63-8.
2010: Todd L Edwards; Stephen D Turner; Eric S Torstenson; Scott M Dudek; Eden R Martin; Marylyn Ritchie
A general framework for formal tests of interaction after exhaustive search methods with applications to MDR and MDR-PDT.
PloS one 2010;5(2):e9363.
2010: Benjamin J Grady; Eric Torstenson; Scott M Dudek; Justin Giles; David Sexton; Marylyn Ritchie
Finding unique filter sets in PLATO: a precursor to efficient interaction analysis in GWAS data.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2010;():315-26.
2009: Simon Body; Charles Collard; Stanton K Shernan; Amanda A Fox; Kuang-Yu Liu; Marylyn Ritchie; Tjörvi E Perry; Jochen Muehlschlegel; Sary F Aranki; Brian S Donahue; Mias Pretorius; Juan-Carlos Estrada; Patrick T Ellinor; Christopher Newton-Cheh; Christine E Seidman; J G Seidman; Daniel S Herman; Peter Lichtner; Thomas Meitinger; Arne Pfeufer; Stefan Kääb; Nancy Brown; Dan Mark Roden; Dawood Darbar
Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery.
Circulation. Cardiovascular genetics 2009;2(5):499-506.
2009: Todd L Edwards; Margaret Pericak-Vance; John Gilbert; Jonathan L Haines; Eden R Martin; Marylyn Ritchie
An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009;150B(5):721-35.
2009: William S Bush; Dana C Crawford; Charles Alexander; Alfred L George; Dan Mark Roden; Marylyn Ritchie
Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias.
Pharmacogenomics 2009;10(6):1043-53.
2009: Chun Li; Ute I Schwarz; Marylyn Ritchie; Dan Mark Roden; C Michael Stein; Daniel Kurnik
Relative contribution of CYP2C9 and VKORC1 genotypes and early INR response to the prediction of warfarin sensitivity during initiation of therapy.
Blood 2009;113(17):3925-30.
2009: Balaji S Srinivasan; Jinbo Chen; Cheng Cheng; David Conti; Shiwei Duan; Brooke L Fridley; Xiangjun Gu; Jonathan L Haines; Eric Jorgenson; Aldi Kraja; Jessica Lasky-Su; Lang Li; Andrei Rodin; Dai Wang; Michael A Province; Marylyn Ritchie
Methods for analysis in pharmacogenomics: lessons from the Pharmacogenetics Research Network Analysis Group.
Pharmacogenomics 2009;10(2):243-51.
2009: William S Bush; Guanhua Chen; Eric S Torstenson; Marylyn Ritchie
LD-spline: mapping SNPs on genotyping platforms to genomic regions using patterns of linkage disequilibrium.
BioData mining 2009;2(1):7.
2009: Marylyn Ritchie
Using prior knowledge and genome-wide association to identify pathways involved in multiple sclerosis.
Genome medicine 2009;1(6):65.
2009: William S Bush; Scott M Dudek; Marylyn Ritchie
Biofilter: a knowledge-integration system for the multi-locus analysis of genome-wide association studies.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2009;():368-79.
2009: Todd L Edwards; Kenneth Lewis; Digna R Velez; Scott Dudek; Marylyn Ritchie
Exploring the performance of Multifactor Dimensionality Reduction in large scale SNP studies and in the presence of genetic heterogeneity among epistatic disease models.
Human heredity 2009;67(3):183-92.
2008: Todd L Edwards; Xu Wang; Qi Chen; Brandon Wormly; Brien Riley; Francis Anthony O'Neill; Dermot Walsh; Marylyn Ritchie; Kenneth S Kendler; Xiangning Chen
Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia.
Schizophrenia research 2008;106(2-3):208-17.
2008: Alison A Motsinger-Reif; David M Reif; Theresa J Fanelli; Marylyn Ritchie
A comparison of analytical methods for genetic association studies.
Genetic epidemiology 2008;32(8):767-78.
2008: Gregory Cooper; Julie A Johnson; Taimour Y Langaee; Hua Feng; Ian B Stanaway; Ute I Schwarz; Marylyn Ritchie; C Michael Stein; Dan Mark Roden; joshua smith; David L Veenstra; Allan E Rettie; Mark J Rieder
A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose.
Blood 2008;112(4):1022-7.
2008: Alison A Motsinger-Reif; Scott M Dudek; Lance W Hahn; Marylyn Ritchie
Comparison of approaches for machine-learning optimization of neural networks for detecting gene-gene interactions in genetic epidemiology.
Genetic epidemiology 2008;32(4):325-40.
2008: Ute I Schwarz; Marylyn Ritchie; Yuki Bradford; Chun Li; Scott M Dudek; Amy Frye-Anderson; Richard B Kim; Dan Mark Roden; C Michael Stein
Genetic determinants of response to warfarin during initial anticoagulation.
The New England journal of medicine 2008;358(10):999-1008.
2008: Dawood Darbar; John Kimbrough; Asif Jawaid; Robert McCray; Marylyn Ritchie; Dan Mark Roden
Persistent atrial fibrillation is associated with reduced risk of torsades de pointes in patients with drug-induced long QT syndrome.
Journal of the American College of Cardiology 2008;51(8):836-42.
2008: Jeffrey A Canter; David W Haas; Asha R Kallianpur; Marylyn Ritchie; Gregory Robbins; Robert W Shafer; David B Clifford; D G Murdock; Todd Hulgan
The mitochondrial pharmacogenomics of haplogroup T: MTND2*LHON4917G and antiretroviral therapy-associated peripheral neuropathy.
The pharmacogenomics journal 2008;8(1):71-7.
2008: Jesús S Aguilar-Ruiz; Jason Moore; Marylyn Ritchie
Filling the gap between biology and computer science.
BioData mining 2008;1(1):1.
2008: Alison A Motsinger-Reif; Marylyn Ritchie
Neural networks for genetic epidemiology: past, present, and future.
BioData mining 2008;1(1):3.
2008: Alison A Motsinger-Reif; Theresa J Fanelli; Anna C Davis; Marylyn Ritchie
Power of grammatical evolution neural networks to detect gene-gene interactions in the presence of error.
BMC research notes 2008;1():65.
2008: William S Bush; Todd L Edwards; Scott M Dudek; Brett A McKinney; Marylyn Ritchie
Alternative contingency table measures improve the power and detection of multifactor dimensionality reduction.
BMC bioinformatics 2008;9():238.
2008: Mias Pretorius; James V Gainer; G P Van Guilder; E B Coelho; James M Luther; P Fong; D D Rosenbaum; Hector A Malave; Chang Yu; Marylyn Ritchie; Douglas E Vaughan; Nancy Brown
The bradykinin type 2 receptor BE1 polymorphism and ethnicity influence systolic blood pressure and vascular resistance.
Clinical pharmacology and therapeutics 2008;83(1):122-9.
2007: Marylyn Ritchie; Todd L Edwards; Theresa J Fanelli; Alison A Motsinger
Genetic heterogeneity is not as threatening as you might think.
Genetic epidemiology 2007;31(7):797-800.
2007: Chia-Ti Tsai; Juey-Jen Hwang; Marylyn Ritchie; Jason Moore; Fu-Tien Chiang; Ling-Ping Lai; Kwan-Lih Hsu; Chuen-Den Tseng; Jiunn-Lee Lin; Yung-Zu Tseng
Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interaction.
Atherosclerosis 2007;195(1):172-80.
2007: Alison A Motsinger; Marylyn Ritchie; David M Reif
Novel methods for detecting epistasis in pharmacogenomics studies.
Pharmacogenomics 2007;8(9):1229-41.
2007: Allison E Ashley-Koch; James M Jaworski; Deqiong Ma; Hao Mei; Marylyn Ritchie; David A Skaar; G Robert Delong; Gordon Worley; Ruth K Abramson; Harry H Wright; Michael Cuccaro; John Gilbert; Eden R Martin; Margaret Pericak-Vance
Investigation of potential gene-gene interactions between APOE and RELN contributing to autism risk.
Psychiatric genetics 2007;17(4):221-6.
2007: scott williams; Jeffrey A Canter; Dana C Crawford; Jason Moore; Marylyn Ritchie; Jonathan L Haines
Problems with genome-wide association studies.
Science (New York, N.Y.) 2007;316(5833):1840-2.
2007: Alison A Motsinger; David W Haas; Todd Hulgan; Marylyn Ritchie
Human genomic association studies: a primer for the infectious diseases specialist.
The Journal of infectious diseases 2007;195(12):1737-44.
2007: Dawood Darbar; Alison A Motsinger; Marylyn Ritchie; James V Gainer; Dan Mark Roden
Polymorphism modulates symptomatic response to antiarrhythmic drug therapy in patients with lone atrial fibrillation.
Heart rhythm : the official journal of the Heart Rhythm Society 2007;4(6):743-9.
2007: Dana C Crawford; Marylyn Ritchie; Mark J Rieder
Identifying the genotype behind the phenotype: a role model found in VKORC1 and its association with warfarin dosing.
Pharmacogenomics 2007;8(5):487-96.
2007: Digna R Velez; Bill C White; Alison A Motsinger; William S Bush; Marylyn Ritchie; scott williams; Jason Moore
A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction.
Genetic epidemiology 2007;31(4):306-15.
2007: Jeffrey A Canter; Marshall Summar; Heidi B Smith; Geraldine D Rice; Lynn D Hall; Marylyn Ritchie; Alison A Motsinger; Karla G Christian; Davis C Drinkwater; Frank G Scholl; Karrie L Dyer; Ann L Kavanaugh-McHugh; Frederick E Barr
Genetic variation in the mitochondrial enzyme carbamyl-phosphate synthetase I predisposes children to increased pulmonary artery pressure following surgical repair of congenital heart defects: a validated genetic association study.
Mitochondrion 2007;7(3):204-10.
2007: Silje H Nordgard; Marylyn Ritchie; Sigrid D Jensrud; Alison A Motsinger; Grethe I G Alnaes; Gordon Lemmon; Marianne Berg; Stephanie Beate Geisler; Jason Moore; Per Eystein Lønning; Anne-Lise Børresen-Dale; Vessela N Kristensen
ABCB1 and GST polymorphisms associated with TP53 status in breast cancer.
Pharmacogenetics and genomics 2007;17(2):127-36.
2007: Marylyn Ritchie; Jacquelaine Bartlett; William S Bush; Todd L Edwards; Alison A Motsinger; Eric S Torstenson
Exploring epistasis in candidate genes for rheumatoid arthritis.
BMC proceedings 2007;1 Suppl 1():S70.
2007: Christopher W Bartlett; Veronica J Vieland; Jacquelaine Bartlett; Jordana T Bell; Samsiddhi Bhattacharjee; Françoise Clerget-Darpoux; William S Bush; Todd L Edwards; Guimin Gao; INDRANI HALDER; Yungui Huang; Salma Kotti; Emma K Larkin; Hua Li; Alison A Motsinger; Nandita Mukhopadhyay; Junghyun Namkung; Taesung Park; Marylyn Ritchie; Catherine M Stein; Ji-Yuan Zhou
Discussing gene-gene interaction: warning--translating equations to English may result in jabberwocky.
Genetic epidemiology 2007;31 Suppl 1():S61-7.
2007: Alison A Motsinger; David Brassat; Stacy J Caillier; Henry A Erlich; Karen Walker; Lori L Steiner; Lisa F Barcellos; Margaret Pericak-Vance; Silke Schmidt; Simon Gregory; Stephen L Hauser; Jonathan L Haines; Jorge R Oksenberg; Marylyn Ritchie
Complex gene-gene interactions in multiple sclerosis: a multifactorial approach reveals associations with inflammatory genes.
Neurogenetics 2007;8(1):11-20.
2006: Alison A Motsinger; Marylyn Ritchie; Robert W Shafer; Gregory Robbins; Gene D Morse; Line Labbe; Grant R Wilkinson; David B Clifford; Richard T D'Aquila; Victoria A Johnson; Richard B Pollard; Thomas C Merigan; Martin S Hirsch; John P Donahue; Richard B Kim; David W Haas
Multilocus genetic interactions and response to efavirenz-containing regimens: an adult AIDS clinical trials group study.
Pharmacogenetics and genomics 2006;16(11):837-45.
2006: David W Haas; Daniel E Geraghty; Janet Andersen; Jessica Mar; Alison A Motsinger; Richard T D'Aquila; Derya Unutmaz; Constance A Benson; Marylyn Ritchie; Alan Landay
Immunogenetics of CD4 lymphocyte count recovery during antiretroviral therapy: An AIDS Clinical Trials Group study.
The Journal of infectious diseases 2006;194(8):1098-107.
2006: Marylyn Ritchie; David W Haas; Alison A Motsinger; John P Donahue; Huso Erdem; Stephen Raffanti; Peter Rebeiro; Alfred L George; Richard B Kim; Jonathan L Haines; Timothy R Sterling
Drug transporter and metabolizing enzyme gene variants and nonnucleoside reverse-transcriptase inhibitor hepatotoxicity.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006;43(6):779-82.
2006: Philip S Crooke; Marylyn Ritchie; David L Hachey; Sheila Dawling; Nady Roodi; Fritz F Parl
Estrogens, enzyme variants, and breast cancer: a risk model.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006;15(9):1620-9.
2006: William S Bush; Scott M Dudek; Marylyn Ritchie
Parallel multifactor dimensionality reduction: a tool for the large-scale analysis of gene-gene interactions.
Bioinformatics (Oxford, England) 2006;22(17):2173-4.
2006: Alison A Motsinger; Marylyn Ritchie
The effect of reduction in cross-validation intervals on the performance of multifactor dimensionality reduction.
Genetic epidemiology 2006;30(6):546-55.
2006: Asha R Kallianpur; Todd Hulgan; Jeffrey A Canter; Marylyn Ritchie; Jonathan L Haines; Gregory Robbins; Robert W Shafer; David B Clifford; David W Haas
Hemochromatosis (HFE) gene mutations and peripheral neuropathy during antiretroviral therapy.
AIDS (London, England) 2006;20(11):1503-13.
2006: Alison A Motsinger; Marylyn Ritchie; Seth E Dobrin
Clinical applications of whole-genome association studies: future applications at the bedside.
Expert review of molecular diagnostics 2006;6(4):551-65.
2006: David Brassat; Alison A Motsinger; Stacy J Caillier; Henry A Erlich; K Walker; Lori L Steiner; Bruce A C Cree; Lisa F Barcellos; Margaret Pericak-Vance; Silke Schmidt; S Gregory; Stephen L Hauser; Jonathan L Haines; Jorge R Oksenberg; Marylyn Ritchie
Multifactor dimensionality reduction reveals gene-gene interactions associated with multiple sclerosis susceptibility in African Americans.
Genes and immunity 2006;7(4):310-5.
2006: Allison E Ashley-Koch; Hao Mei; James M Jaworski; Deqiong Ma; Marylyn Ritchie; Marisa M Menold; G Robert DeLong; Ruth K Abramson; Harry H Wright; John Peter Hussman; Michael Cuccaro; John Gilbert; Eden R Martin; Margaret Pericak-Vance
An analysis paradigm for investigating multi-locus effects in complex disease: examination of three GABA receptor subunit genes on 15q11-q13 as risk factors for autistic disorder.
Annals of human genetics 2006;70(Pt 3):281-92.
2006: Alison A Motsinger; Marylyn Ritchie
Multifactor dimensionality reduction: an analysis strategy for modelling and detecting gene-gene interactions in human genetics and pharmacogenomics studies.
Human genomics 2006;2(5):318-28.
2006: Hironobu Sanada; Junichi Yatabe; Sanae Midorikawa; Shigeatsu Hashimoto; Tsuyoshi Watanabe; Jason Moore; Marylyn Ritchie; scott williams; John C Pezzullo; Midori Sasaki; Gilbert M Eisner; Pedro Jose; Robin A Felder
Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension.
Clinical chemistry 2006;52(3):352-60.
2006: Harumi Takahashi; Grant R Wilkinson; Edith A Nutescu; Takashi Morita; Marylyn Ritchie; Maria Gabriella Scordo; Vittorio Pengo; Martina Barban; Roberto Padrini; Ichiro Ieiri; Kenji Otsubo; Toshitaka Kashima; Sosuke Kimura; Shinichi Kijima; Hirotoshi Echizen
Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans.
Pharmacogenetics and genomics 2006;16(2):101-10.
2006: Eden R Martin; Marylyn Ritchie; Lance W Hahn; S Kang; Jason Moore
A novel method to identify gene-gene effects in nuclear families: the MDR-PDT.
Genetic epidemiology 2006;30(2):111-23.
2006: Alison A Motsinger; Brian S Donahue; Nancy Brown; Dan Mark Roden; Marylyn Ritchie
Risk factor interactions and genetic effects associated with post-operative atrial fibrillation.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2006;():584-95.
2006: Scott M Dudek; Alison A Motsinger; Digna R Velez; scott williams; Marylyn Ritchie
Data simulation software for whole-genome association and other studies in human genetics.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2006;():499-510.
2006: Brett A McKinney; David M Reif; Marylyn Ritchie; Jason Moore
Machine learning for detecting gene-gene interactions: a review.
Applied bioinformatics 2006;5(2):77-88.
2006: Alison A Motsinger; Stephen L Lee; George Mellick; Marylyn Ritchie
GPNN: power studies and applications of a neural network method for detecting gene-gene interactions in studies of human disease.
BMC bioinformatics 2006;7():39.
2005: Marylyn Ritchie; Alison A Motsinger
Multifactor dimensionality reduction for detecting gene-gene and gene-environment interactions in pharmacogenomics studies.
Pharmacogenomics 2005;6(8):823-34.
2005: Marylyn Ritchie
Trends in genomic variation: a view of some of the latest technologies.
Drug discovery today 2005;10(21):1417-8.
2005: Marylyn Ritchie
Bioinformatics approaches for detecting gene-gene and gene-environment interactions in studies of human disease.
Neurosurgical focus 2005;19(4):E2.
2005: Todd Hulgan; David W Haas; Jonathan L Haines; Marylyn Ritchie; Gregory Robbins; Robert W Shafer; David B Clifford; Asha R Kallianpur; Marshall Summar; Jeffrey A Canter
Mitochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: an adult AIDS clinical trials group study.
AIDS (London, England) 2005;19(13):1341-9.
2005: Deqiong Ma; P L Whitehead; Marisa M Menold; Eden R Martin; Allison E Ashley-Koch; Hao Mei; Marylyn Ritchie; G Robert DeLong; Ruth K Abramson; Harry H Wright; Michael Cuccaro; John Peter Hussman; John Gilbert; Margaret Pericak-Vance
Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism.
American journal of human genetics 2005;77(3):377-88.
2005: Russell A Wilke; Michelle W Carrillo; Marylyn Ritchie
Pacific Symposium on Biocomputing--computational approaches for pharmacogenomics.
Pharmacogenomics 2005;6(2):111-3.
2005: Miguel Luz Soares; Teresa Coelho; Alda Sousa; Serge Batalov; Isabel Conceição; Maria L Sales-Luís; Marylyn Ritchie; scott williams; Caroline Nievergelt; Nicholas J Schork; Maria João Saraiva; Joel N Buxbaum
Susceptibility and modifier genes in Portuguese transthyretin V30M amyloid polyneuropathy: complexity in a single-gene disease.
Human molecular genetics 2005;14(4):543-53.
2005: Marylyn Ritchie; Michelle W Carillo; Russell A Wilke
Computational approaches for pharmacogenomics.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2005;():245-7.
2004: Amanda M Vanhoose; Marylyn Ritchie; Danny G Winder
Regulation of cAMP levels in area CA1 of hippocampus by Gi/o-coupled receptors is stimulus dependent in mice.
Neuroscience letters 2004;370(1):80-3.
2004: Nah-Young Shin; Rebecca S Dise; Jens Schneider-Mergener; Marylyn Ritchie; Dawn M Kilkenny; Steven K Hanks
Subsets of the major tyrosine phosphorylation sites in Crk-associated substrate (CAS) are sufficient to promote cell migration.
The Journal of biological chemistry 2004;279(37):38331-7.
2004: Christopher S Coffey; Patricia R Hebert; Marylyn Ritchie; Harlan Krumholz; J Michael Gaziano; Paul M Ridker; Nancy J Brown; Douglas E Vaughan; Jason Moore
An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: the importance of model validation.
BMC bioinformatics 2004;5():49.
2004: Jason Moore; Marylyn Ritchie
STUDENTJAMA. The challenges of whole-genome approaches to common diseases.
JAMA : the journal of the American Medical Association 2004;291(13):1642-3.
2004: Chia-Ti Tsai; Ling-Ping Lai; Jiunn-Lee Lin; Fu-Tien Chiang; Juey-Jen Hwang; Marylyn Ritchie; Jason Moore; Kwan-Lih Hsu; Chuen-Den Tseng; Chiau-Suong Liau; Yung-Zu Tseng
Renin-angiotensin system gene polymorphisms and atrial fibrillation.
Circulation 2004;109(13):1640-6.
2004: Young Min Cho; Marylyn Ritchie; J H Moore; Joong-Yeol Park; Ki-Up Lee; Hyoung Doo Shin; Hong Kyu Lee; Kyong Soo Park
Multifactor-dimensionality reduction shows a two-locus interaction associated with Type 2 diabetes mellitus.
Diabetologia 2004;47(3):549-54.
2004: scott williams; Marylyn Ritchie; John A Phillips; Elliot Dawson; Melissa Prince; Elvira Dzhura; Alecia Willis; Amma Semenya; Marshall Summar; Bill C White; Jonathan H Addy; John Kpodonu; Lee-Jun C Wong; Robin A Felder; Pedro Jose; Jason Moore
Multilocus analysis of hypertension: a hierarchical approach.
Human heredity 2004;57(1):28-38.
2003: Jason Moore; Tricia A Thornton; Marylyn Ritchie
Basic statistics.
Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.] 2003;Appendix 3():Appendix 3M.
2003: Marylyn Ritchie; Bill C White; Joel Parker; Lance W Hahn; Jason Moore
Optimization of neural network architecture using genetic programming improves detection and modeling of gene-gene interactions in studies of human diseases.
BMC bioinformatics 2003;4():28.
2003: Lance W Hahn; Marylyn Ritchie; Jason Moore
Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions.
Bioinformatics (Oxford, England) 2003;19(3):376-82.
2003: Marylyn Ritchie; Lance W Hahn; Jason Moore
Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity.
Genetic epidemiology 2003;24(2):150-7.
2002: John C Donaldson; Rebecca S Dise; Marylyn Ritchie; Steven K Hanks
Nephrocystin-conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity.
The Journal of biological chemistry 2002;277(32):29028-35.
2001: Marylyn Ritchie; Lance W Hahn; Nady Roodi; LR Bailey; William D Dupont; Fritz F Parl; Jason Moore
Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer.
American journal of human genetics 2001;69(1):138-47.