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Stefan Hart

Research Profile

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Publications

TOP 3
veronica Novotny-diermayr; L-C Ong; M K Pasha; A Cheong; K Ethirajulu; K C Goh; Stefan Hart; H Hentze; R Jayaraman; J M Wood
The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AML.
K C Goh; Stefan Hart; C Hu; R Jayaraman; Y K Loh; veronica Novotny-diermayr; K H Ong; L C Ong; E T Sun; Y C Tan; A D William; F Burrows; A Cheong; B W Dymock; K Ethirajulu; J M Wood
TG02, a novel oral multi-kinase inhibitor of CDKs, JAK2 and FLT3 with potent anti-leukemic properties.
Stefan Hart; B Kheng; B Madan; veronica Novotny-diermayr; L C Ong; Y C Tan; C Amalini; A Cheong; W J Chng; K C Goh; J Zhou; J M Wood
Pacritinib (SB1518), a JAK2/FLT3 inhibitor for the treatment of acute myeloid leukemia.

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All Publications

2012: veronica Novotny-diermayr; L-C Ong; M K Pasha; A Cheong; K Ethirajulu; K C Goh; Stefan Hart; H Hentze; R Jayaraman; J M Wood
The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AML.
Blood cancer journal 2012;2(5):e69.
2012: K C Goh; Stefan Hart; C Hu; R Jayaraman; Y K Loh; veronica Novotny-diermayr; K H Ong; L C Ong; E T Sun; Y C Tan; A D William; F Burrows; A Cheong; B W Dymock; K Ethirajulu; J M Wood
TG02, a novel oral multi-kinase inhibitor of CDKs, JAK2 and FLT3 with potent anti-leukemic properties.
Leukemia 2012;26(2):236-43.
2011: Stefan Hart; B Kheng; B Madan; veronica Novotny-diermayr; L C Ong; Y C Tan; C Amalini; A Cheong; W J Chng; K C Goh; J Zhou; J M Wood
Pacritinib (SB1518), a JAK2/FLT3 inhibitor for the treatment of acute myeloid leukemia.
Blood cancer journal 2011;1(11):e44.
2011: Stefan Hart; H Hentze; C Y Hu; R Jayaraman; A Lee; Y K Loh; B Madan; veronica Novotny-diermayr; K H Ong; L C Ong; A Poulsen; Y C Tan; A D William; C Amalini; B W Dymock; K Ethirajulu; K C Goh; J W Wood
SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies.
Leukemia 2011;25(11):1751-9.
2010: A Roidl; P Foo; W Wong; C Mann; S Bechtold; Hans-Jürgen Berger; Sylvia Streit; Jens E Ruhe; Stefan Hart; Axel Ullrich; H K Ho
The FGFR4 Y367C mutant is a dominant oncogene in MDA-MB453 breast cancer cells.
Oncogene 2010;29(10):1543-52.
2010: veronica Novotny-diermayr; Kanda Sangthongpitag; Chang Yong Hu; Xiaofeng Wu; Nina Sausgruber; Pauline Yeo; Gediminas Greicius; Sven Pettersson; Ai Leng Liang; Yung Kiang Loh; Zahid Bonday; Kee Chuan Goh; Hannes Hentze; Stefan Hart; Haishan Wang; Kantharaj Ethirajulu; Jeanette Marjorie Wood
SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer.
Molecular cancer therapeutics 2010;9(3):642-52.
2009: Han Kiat Ho; Sharon Pok; Sylvia Streit; Jens E Ruhe; Stefan Hart; Kah Suan Lim; Hooi Linn Loo; Myat Oo Aung; Seng Gee Lim; Axel Ullrich
Fibroblast growth factor receptor 4 regulates proliferation, anti-apoptosis and alpha-fetoprotein secretion during hepatocellular carcinoma progression and represents a potential target for therapeutic intervention.
Journal of hepatology 2009;50(1):118-27.
2007: Jens E Ruhe; Sylvia Streit; Stefan Hart; Chee-Hong Wong; Katja Specht; Pjotr Knyazev; Tatjana Knyazeva; Liang Seah Tay; Hooi Linn Loo; Priscilla Foo; Winnie Wong; Sharon Pok; Shu Jing Lim; Huimin Ong; Ming Luo; Han Kiat Ho; Kaitian Peng; Tze Chuen Lee; Martin Bezler; Christian Mann; Silvia Gaertner; Heinz Hoefler; Stefano Iacobelli; Stephan Peter; Alice Tay; Sydney Brenner; Byrappa Venkatesh; Axel Ullrich
Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines.
Cancer research 2007;67(23):11368-76.
2006: Jens E Ruhe; Sylvia Streit; Stefan Hart; Axel Ullrich
EGFR signaling leads to downregulation of PTP-LAR via TACE-mediated proteolytic processing.
Cellular signalling 2006;18(9):1515-27.
2006: Oliver M Fischer; Stefan Hart; Axel Ullrich
Dissecting the epidermal growth factor receptor signal transactivation pathway.
Methods in molecular biology (Clifton, N.J.) 2006;327():85-97.
2005: Stefan Hart; Oliver M Fischer; Norbert Prenzel; Esther Zwick-Wallasch; Matthias Schneider; Lothar Hennighausen; Axel Ullrich
GPCR-induced migration of breast carcinoma cells depends on both EGFR signal transactivation and EGFR-independent pathways.
Biological chemistry 2005;386(9):845-55.
2004: Ling Zhao; Stefan Hart; JrGang Cheng; J Joseph Melenhorst; Brian Bierie; Matthias Ernst; Colin Stewart; Fred Schaper; Peter C Heinrich; Axel Ullrich; Gertraud W Robinson; Lothar Hennighausen
Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK.
The Journal of biological chemistry 2004;279(42):44093-100.
2004: Oliver M Fischer; Stefan Hart; Andreas Gschwind; Norbert Prenzel; Axel Ullrich
Oxidative and osmotic stress signaling in tumor cells is mediated by ADAM proteases and heparin-binding epidermal growth factor.
Molecular and cellular biology 2004;24(12):5172-83.
2004: Stefan Hart; Oliver M Fischer; Axel Ullrich
Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor.
Cancer research 2004;64(6):1943-50.
2003: Oliver M Fischer; Stefan Hart; Andreas Gschwind; Axel Ullrich
EGFR signal transactivation in cancer cells.
Biochemical Society transactions 2003;31(Pt 6):1203-8.
2003: Oliver M Fischer; Sylvia Streit; Stefan Hart; Axel Ullrich
Beyond Herceptin and Gleevec.
Current opinion in chemical biology 2003;7(4):490-5.
2003: Andreas Gschwind; Stefan Hart; Oliver M Fischer; Axel Ullrich
TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells.
The EMBO journal 2003;22(10):2411-21.
2001: Norbert Prenzel; Oliver M Fischer; Sylvia Streit; Stefan Hart; Axel Ullrich
The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification.
Endocrine-related cancer 2001;8(1):11-31.