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Françoise Van Bambeke

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Chemicals & Drugs

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Julia Bauer; Wafi Siala; Paul M Tulkens; Françoise Van Bambeke
A Combined Pharmacodynamic Quantitative and Qualitative Model Reveals the Potent Activity of Daptomycin and Delafloxacin against Staphylococcus aureus Biofilms.
julien buyck; Paul M Tulkens; Françoise Van Bambeke
Pharmacodynamic evaluation of the intracellular activity of antibiotics towards Pseudomonas aeruginosa PAO1 in a model of THP-1 human monocytes.
Aurélie Mélard; Raoul Rozenberg; Paul M Tulkens; Françoise Van Bambeke; Debaditya Das; Laetitia G Garcia; Sandrine Lemaire
Activity of ceftaroline against extracellular (broth) and intracellular (THP-1 monocytes) forms of methicillin-resistant Staphylococcus aureus: comparison with vancomycin, linezolid and daptomycin.

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All Publications

2013: Julia Bauer; Wafi Siala; Paul M Tulkens; Françoise Van Bambeke
A Combined Pharmacodynamic Quantitative and Qualitative Model Reveals the Potent Activity of Daptomycin and Delafloxacin against Staphylococcus aureus Biofilms.
Antimicrobial agents and chemotherapy 2013;57(6):2726-37.
2013: julien buyck; Paul M Tulkens; Françoise Van Bambeke
Pharmacodynamic evaluation of the intracellular activity of antibiotics towards Pseudomonas aeruginosa PAO1 in a model of THP-1 human monocytes.
Antimicrobial agents and chemotherapy 2013;57(5):2310-8.
2013: Aurélie Mélard; Raoul Rozenberg; Paul M Tulkens; Françoise Van Bambeke; Debaditya Das; Laetitia G Garcia; Sandrine Lemaire
Activity of ceftaroline against extracellular (broth) and intracellular (THP-1 monocytes) forms of methicillin-resistant Staphylococcus aureus: comparison with vancomycin, linezolid and daptomycin.
The Journal of antimicrobial chemotherapy 2013;68(3):648-58.
2013: Nancy E Caceres; Bart Devreese; Béatrice Marquez; Marie-Paule Mingeot-Leclercq; Paul M Tulkens; Maarten Aerts; Françoise Van Bambeke
Analysis of the membrane proteome of ciprofloxacin-resistant macrophages by stable isotope labeling with amino acids in cell culture (SILAC).
PloS one 2013;8(3):e58285.
2012: Laetitia G Garcia; Barbara C Kahl; Sandrine Lemaire; Richard A Proctor; Paul M Tulkens; Karsten Becker; Françoise Van Bambeke
Intracellular forms of menadione-dependent small-colony variants of methicillin-resistant Staphylococcus aureus are hypersusceptible to β-lactams in a THP-1 cell model due to cooperation between vacuolar acidic pH and oxidant species.
The Journal of antimicrobial chemotherapy 2012;67(12):2873-81.
2012: Laetitia G Garcia; Barbara C Kahl; Sandrine Lemaire; Richard A Proctor; Paul M Tulkens; Karsten Becker; Françoise Van Bambeke
Influence of the protein kinase C activator phorbol myristate acetate on the intracellular activity of antibiotics against hemin- and menadione-auxotrophic small-colony variant mutants of Staphylococcus aureus and their wild-type parental strain in human THP-1 cells.
Antimicrobial agents and chemotherapy 2012;56(12):6166-74.
2012: Edurne Imbuluzqueta; Sandrine Lemaire; Françoise Van Bambeke; Jaume Veciana; Nora Ventosa; Elisa Elizondo; Carlos Gamazo; María J Blanco-Prieto
Cellular pharmacokinetics and intracellular activity against Listeria monocytogenes and Staphylococcus aureus of chemically modified and nanoencapsulated gentamicin.
The Journal of antimicrobial chemotherapy 2012;67(9):2158-64.
2012: julien buyck; Patrick Plésiat; Hamidou Traore; Paul M Tulkens; Francis Vanderbist; Françoise Van Bambeke
Increased susceptibility of Pseudomonas aeruginosa to macrolides and ketolides in eukaryotic cell culture media and biological fluids due to decreased expression of oprM and increased outer-membrane permeability.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012;55(4):534-42.
2012: L G Garcia; B C Kahl; Sandrine Lemaire; R A Proctor; Paul Tulkens; K Becker; O Denis; Françoise Van Bambeke
Pharmacodynamic evaluation of the activity of antibiotics against hemin- and menadione-dependent small-colony variants of Staphylococcus aureus in models of extracellular (broth) and intracellular (THP-1 monocytes) infections.
Antimicrobial agents and chemotherapy 2012;56(7):3700-11.
2012: Beverlie Baquir; Sandrine Lemaire; Lin Lin; Paul M Tulkens; Françoise Van Bambeke; Brad Spellberg
Macrophage killing of bacterial and fungal pathogens is not inhibited by intense intracellular accumulation of the lipoglycopeptide antibiotic oritavancin.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012;54 Suppl 3():S229-32.
2012: Ann Lismond; Patricia Schatt; Paul M Tulkens; Sylviane Carbonnelle; Annelies De Bel; Anne Dediste; Youri Glupczynski; Te-Din Huang; Frédérique Jacobs; Paul Jordens; Jan Verhaegen; Frank Verschuren; Françoise Van Bambeke
Antimicrobial susceptibility of Streptococcus pneumoniae isolates from vaccinated and non-vaccinated patients with a clinically confirmed diagnosis of community-acquired pneumonia in Belgium.
International journal of antimicrobial agents 2012;39(3):208-16.
2012: julien buyck; Sophie Guénard; Patrick Plésiat; Paul M Tulkens; Françoise Van Bambeke
Role of MexAB-OprM in intrinsic resistance of Pseudomonas aeruginosa to temocillin and impact on the susceptibility of strains isolated from patients suffering from cystic fibrosis.
The Journal of antimicrobial chemotherapy 2012;67(3):771-5.
2011: Coralie M Vallet; Ahalieyah Anantharajah; Eric Jacquet; Jean-Yves Lallemand; Béatrice Marquez; Marie-Paule Mingeot-Leclercq; Naïma Nhiri; Paul Tulkens; Françoise Van Bambeke
Modulation of the expression of ABC transporters in murine (J774) macrophages exposed to large concentrations of the fluoroquinolone antibiotic moxifloxacin.
Toxicology 2011;290(2-3):178-86.
2011: Sophie Denamur; Jacqueline Marchand-Brynaert; Paul Tulkens; Donatienne Tyteca; Françoise Van Bambeke; Pierre J Courtoy; Marie-Paule Mingeot-Leclercq
Role of oxidative stress in lysosomal membrane permeabilization and apoptosis induced by gentamicin, an aminoglycoside antibiotic.
Free radical biology & medicine 2011;51(9):1656-65.
2011: Coralie M Vallet; Sandrine Lemaire; Béatrice Marquez; Marie-Paule Mingeot-Leclercq; Eva Ngabirano; Paul Tulkens; Françoise Van Bambeke
Cellular accumulation of fluoroquinolones is not predictive of their intracellular activity: studies with gemifloxacin, moxifloxacin and ciprofloxacin in a pharmacokinetic/pharmacodynamic model of uninfected and infected macrophages.
International journal of antimicrobial agents 2011;38(3):249-56.
2011: Sandrine Lemaire; Françoise Van Bambeke; Paul Tulkens
Activity of finafloxacin, a novel fluoroquinolone with increased activity at acid pH, towards extracellular and intracellular Staphylococcus aureus, Listeria monocytogenes and Legionella pneumophila.
International journal of antimicrobial agents 2011;38(1):52-9.
2011: Françoise Van Bambeke
ABC transporters: role in modulation of drug pharmacokinetics and in physiopathology and therapeutic perspectives.
Current drug targets 2011;12(5):598-9.
2011: Béatrice Marquez; Françoise Van Bambeke
ABC multidrug transporters: target for modulation of drug pharmacokinetics and drug-drug interactions.
Current drug targets 2011;12(5):600-20.
2011: Ann Lismond; Sylviane Carbonnelle; Paul Tulkens; Françoise Van Bambeke
Efflux of novel quinolones in contemporary Streptococcus pneumoniae isolates from community-acquired pneumonia.
The Journal of antimicrobial chemotherapy 2011;66(4):948-51.
2011: Anne Sandberg; Sandrine Lemaire; Françoise Van Bambeke; Paul Tulkens; Diarmaid Hughes; Christof von Eiff; Niels Frimodt-Møller
Intra- and extracellular activities of dicloxacillin and linezolid against a clinical Staphylococcus aureus strain with a small-colony-variant phenotype in an in vitro model of THP-1 macrophages and an in vivo mouse peritonitis model.
Antimicrobial agents and chemotherapy 2011;55(4):1443-52.
2011: Sandrine Lemaire; Klaudia Kosowska-Shick; Peter C Appelbaum; Y Glupczynski; Françoise Van Bambeke; Paul Tulkens
Activity of moxifloxacin against intracellular community-acquired methicillin-resistant Staphylococcus aureus: comparison with clindamycin, linezolid and co-trimoxazole and attempt at defining an intracellular susceptibility breakpoint.
The Journal of antimicrobial chemotherapy 2011;66(3):596-607.
2011: Sandrine Lemaire; Paul Tulkens; Françoise Van Bambeke
Contrasting effects of acidic pH on the extracellular and intracellular activities of the anti-gram-positive fluoroquinolones moxifloxacin and delafloxacin against Staphylococcus aureus.
Antimicrobial agents and chemotherapy 2011;55(2):649-58.
2010: Jean-Paul Becker; Françoise Van Bambeke; Paul Tulkens; Martine Prévost
Dynamics and structural changes induced by ATP binding in SAV1866, a bacterial ABC exporter.
The journal of physical chemistry. B 2010;114(48):15948-57.
2010: Mickaël Riou; Sylviane Carbonnelle; Laëtitia Avrain; Narcisa Mesaros; Jean-Paul Pirnay; Florence Bilocq; Daniel De Vos; Anne Simon; Denis Piérard; Frédérique Jacobs; Anne Dediste; Paul Tulkens; Françoise Van Bambeke; Youri Glupczynski
In vivo development of antimicrobial resistance in Pseudomonas aeruginosa strains isolated from the lower respiratory tract of Intensive Care Unit patients with nosocomial pneumonia and receiving antipseudomonal therapy.
International journal of antimicrobial agents 2010;36(6):513-22.
2010: Farid El Garch; Ann Lismond; Laura J V Piddock; Patrice Courvalin; Paul Tulkens; Françoise Van Bambeke
Fluoroquinolones induce the expression of patA and patB, which encode ABC efflux pumps in Streptococcus pneumoniae.
The Journal of antimicrobial chemotherapy 2010;65(10):2076-82.
2010: Oscar Domenech; Yves F Dufrêne; Françoise Van Bambeke; Paul M Tukens; Marie-Paule Mingeot-Leclercq
Interactions of oritavancin, a new semi-synthetic lipoglycopeptide, with lipids extracted from Staphylococcus aureus.
Biochimica et biophysica acta 2010;1798(10):1876-85.
2010: Karoline Sidelmann Brinch; Paul Tulkens; Françoise Van Bambeke; Niels Frimodt-Møller; Niels Høiby; Hans-Henrik Kristensen
Intracellular activity of the peptide antibiotic NZ2114: studies with Staphylococcus aureus and human THP-1 monocytes, and comparison with daptomycin and vancomycin.
The Journal of antimicrobial chemotherapy 2010;65(8):1720-4.
2010: Sandrine Lemaire; Paul Tulkens; Françoise Van Bambeke
Cellular pharmacokinetics of the novel biaryloxazolidinone radezolid in phagocytic cells: studies with macrophages and polymorphonuclear neutrophils.
Antimicrobial agents and chemotherapy 2010;54(6):2540-8.
2010: Sandrine Lemaire; Klaudia Kosowska-Shick; Peter C Appelbaum; Gunther Verween; Paul Tulkens; Françoise Van Bambeke
Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila.
Antimicrobial agents and chemotherapy 2010;54(6):2549-59.
2010: Pierre Baudoux; Sandrine Lemaire; Olivier Denis; Paul Tulkens; Françoise Van Bambeke; Youri Glupczynski
Activity of quinupristin/dalfopristin against extracellular and intracellular Staphylococcus aureus with various resistance phenotypes.
The Journal of antimicrobial chemotherapy 2010;65(6):1228-36.
2010: Anne Sandberg; Klaus Skovbo Jensen; Pierre Baudoux; Françoise Van Bambeke; Paul Tulkens; Niels Frimodt-Møller
Intra- and extracellular activities of dicloxacillin against Staphylococcus aureus in vivo and in vitro.
Antimicrobial agents and chemotherapy 2010;54(6):2391-400.
2010: Anne Sandberg; Klaus Skovbo Jensen; Pierre Baudoux; Françoise Van Bambeke; Paul Tulkens; Niels Frimodt-Møller
Intra- and extracellular activity of linezolid against Staphylococcus aureus in vivo and in vitro.
The Journal of antimicrobial chemotherapy 2010;65(5):962-73.
2009: Sébastien Van de Velde; Edouard Delaive; Marc Dieu; Stéphane Carryn; Françoise Van Bambeke; Bart Devreese; Martine Raes; Paul Tulkens
Isolation and 2-D-DIGE proteomic analysis of intracellular and extracellular forms of Listeria monocytogenes.
Proteomics 2009;9(24):5484-96.
2009: Aurélie C Olivier; Sandrine Lemaire; Françoise Van Bambeke; Paul Tulkens; Eric Oldfield
Role of rsbU and staphyloxanthin in phagocytosis and intracellular growth of Staphylococcus aureus in human macrophages and endothelial cells.
The Journal of infectious diseases 2009;200(9):1367-70.
2009: Sandrine Lemaire; Françoise Van Bambeke; Peter C Appelbaum; Paul Tulkens
Cellular pharmacokinetics and intracellular activity of torezolid (TR-700): studies with human macrophage (THP-1) and endothelial (HUVEC) cell lines.
The Journal of antimicrobial chemotherapy 2009;64(5):1035-43.
2009: Karoline Sidelmann Brinch; Anne Sandberg; Pierre Baudoux; Françoise Van Bambeke; Paul Tulkens; Niels Frimodt-Møller; Niels Høiby; Hans-Henrik Kristensen
Plectasin shows intracellular activity against Staphylococcus aureus in human THP-1 monocytes and in a mouse peritonitis model.
Antimicrobial agents and chemotherapy 2009;53(11):4801-8.
2009: Carlo Franchini; Marilena Muraglia; Filomena Corbo; Marco Antonio Florio; Antonia Di Mola; Antonio Rosato; Rosanna Matucci; Marta Nesi; Françoise Van Bambeke; Cesare Vitali
Synthesis and biological evaluation of 2-mercapto-1,3-benzothiazole derivatives with potential antimicrobial activity.
Archiv der Pharmazie 2009;342(10):605-13.
2009: Sandrine Lemaire; Françoise Van Bambeke; Paul Tulkens
Cellular accumulation and pharmacodynamic evaluation of the intracellular activity of CEM-101, a novel fluoroketolide, against Staphylococcus aureus, Listeria monocytogenes, and Legionella pneumophila in human THP-1 macrophages.
Antimicrobial agents and chemotherapy 2009;53(9):3734-43.
2009: Oscar Domenech; Grégory Francius; Paul Tulkens; Françoise Van Bambeke; Yves F Dufrêne; Marie-Paule Mingeot-Leclercq
Interactions of oritavancin, a new lipoglycopeptide derived from vancomycin, with phospholipid bilayers: Effect on membrane permeability and nanoscale lipid membrane organization.
Biochimica et biophysica acta 2009;1788(9):1832-40.
2009: Françoise Van Bambeke; Paul Tulkens
[Pharmacodynamics of antibiotics in CSF: principles and consequences (predictive factors of efficacy)].
Médecine et maladies infectieuses 2009;39(7-8):483-92.
2009: Béatrice Marquez; Nancy E Caceres; Marie-Paule Mingeot-Leclercq; Paul Tulkens; Françoise Van Bambeke
Identification of the efflux transporter of the fluoroquinolone antibiotic ciprofloxacin in murine macrophages: studies with ciprofloxacin-resistant cells.
Antimicrobial agents and chemotherapy 2009;53(6):2410-6.
2009: Sandrine Lemaire; Youri Glupczynski; Valérie Duval; Bernard Joris; Paul Tulkens; Françoise Van Bambeke
Activities of ceftobiprole and other cephalosporins against extracellular and intracellular (THP-1 macrophages and keratinocytes) forms of methicillin-susceptible and methicillin-resistant Staphylococcus aureus.
Antimicrobial agents and chemotherapy 2009;53(6):2289-97.
2009: Hoang Anh NGUYEN; Olivier Denis; Anne Vergison; Paul Tulkens; Marc Jean Struelens; Françoise Van Bambeke
Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: study of antibiotic combinations.
Antimicrobial agents and chemotherapy 2009;53(4):1443-9.
2009: Hoang Anh NGUYEN; Olivier Denis; Anne Vergison; Anne Theunis; Paul Tulkens; Marc Jean Struelens; Françoise Van Bambeke
Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype and revertant strains.
Antimicrobial agents and chemotherapy 2009;53(4):1434-42.
2009: Sébastien Van de Velde; Stéphane Carryn; Françoise Van Bambeke; Colin Hill; Paul Tulkens; Roy D Sleator
Penicillin-binding proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes.
Gut pathogens 2009;1():23.
2009: I Tytgat; E Colacino; Paul Tulkens; J H Poupaert; M Prévost; Françoise Van Bambeke
DD-ligases as a potential target for antibiotics: past, present and future.
Current medicinal chemistry 2009;16(20):2566-80.
2009: Françoise Van Bambeke; Paul Tulkens
Safety profile of the respiratory fluoroquinolone moxifloxacin: comparison with other fluoroquinolones and other antibacterial classes.
Drug safety : an international journal of medical toxicology and drug experience 2009;32(5):359-78.
2009: Jean-Paul Becker; Grégoire Depret; Françoise Van Bambeke; Paul Tulkens; Martine Prévost
Molecular models of human P-glycoprotein in two different catalytic states.
BMC structural biology 2009;9():3.
2008: Hayet Bensikaddour; Karim Snoussi; laurence lins; Françoise Van Bambeke; Paul Tulkens; Robert Brasseur; Erik Goormaghtigh; Marie-Paule Mingeot-Leclercq
Interactions of ciprofloxacin with DPPC and DPPG: fluorescence anisotropy, ATR-FTIR and 31P NMR spectroscopies and conformational analysis.
Biochimica et biophysica acta 2008;1778(11):2535-43.
2008: Ann Lismond; Paul Tulkens; Marie-Paule Mingeot-Leclercq; Patrice Courvalin; Françoise Van Bambeke
Cooperation between prokaryotic (Lde) and eukaryotic (MRP) efflux transporters in J774 macrophages infected with Listeria monocytogenes: studies with ciprofloxacin and moxifloxacin.
Antimicrobial agents and chemotherapy 2008;52(9):3040-6.
2008: Sébastien Van de Velde; Hoang Anh NGUYEN; Françoise Van Bambeke; Paul Tulkens; Jean Grellet; Véronique Dubois; Claudine Quentin; Marie-Claude Saux
Contrasting effects of human THP-1 cell differentiation on levofloxacin and moxifloxacin intracellular accumulation and activity against Staphylococcus aureus and Listeria monocytogenes.
The Journal of antimicrobial chemotherapy 2008;62(3):518-21.
2008: Sandrine Lemaire; K Kosowska-Shick; K Julian; Paul Tulkens; Françoise Van Bambeke; P C Appelbaum
Activities of antistaphylococcal antibiotics towards the extracellular and intraphagocytic forms of Staphylococcus aureus isolates from a patient with persistent bacteraemia and endocarditis.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2008;14(8):766-77.
2008: Sandrine Lemaire; Aurélie Olivier; Françoise Van Bambeke; Paul Tulkens; Peter C Appelbaum; Youri Glupczynski
Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
Antimicrobial agents and chemotherapy 2008;52(8):2797-805.
2008: Sophie Denamur; Françoise Van Bambeke; Marie-Paule Mingeot-Leclercq; Paul Tulkens
Apoptosis induced by aminoglycosides in LLC-PK1 Cells: comparative study of neomycin, gentamicin, amikacin, and isepamicin using electroporation.
Antimicrobial agents and chemotherapy 2008;52(6):2236-8.
2008: Maritza Barcia-Macay; Fatima Mouaden; Marie-Paule Mingeot-Leclercq; Paul Tulkens; Françoise Van Bambeke
Cellular pharmacokinetics of telavancin, a novel lipoglycopeptide antibiotic, and analysis of lysosomal changes in cultured eukaryotic cells (J774 mouse macrophages and rat embryonic fibroblasts).
The Journal of antimicrobial chemotherapy 2008;61(6):1288-94.
2008: Sandrine Lemaire; Cosimo Fuda; Françoise Van Bambeke; Paul Tulkens; Shahriar Mobashery
Restoration of susceptibility of methicillin-resistant Staphylococcus aureus to beta-lactam antibiotics by acidic pH: role of penicillin-binding protein PBP 2a.
The Journal of biological chemistry 2008;283(19):12769-76.
2008: Françoise Van Bambeke
[The ABC of viral hepatitis].
Journal de pharmacie de Belgique 2008;63(1):15-20.
2008: Françoise Van Bambeke; Marie-Paule Mingeot-Leclercq; Marc Jean Struelens; Paul Tulkens
The bacterial envelope as a target for novel anti-MRSA antibiotics.
Trends in pharmacological sciences 2008;29(3):124-34.
2008: Françoise Van Bambeke; Joerg M Harms; Yves Van Laethem; Paul Tulkens
Ketolides: pharmacological profile and rational positioning in the treatment of respiratory tract infections.
Expert opinion on pharmacotherapy 2008;9(2):267-83.
2007: Laetitia Avrain; Mark Garvey; Narcisa Mesaros; Youri Glupczynski; Marie-Paule Mingeot-Leclercq; Laura J V Piddock; Paul Tulkens; Raymond Vanhoof; Françoise Van Bambeke
Selection of quinolone resistance in Streptococcus pneumoniae exposed in vitro to subinhibitory drug concentrations.
The Journal of antimicrobial chemotherapy 2007;60(5):965-72.
2007: Sandrine Lemaire; Françoise Van Bambeke; Marie-Paule Mingeot-Leclercq; Paul Tulkens
Modulation of the cellular accumulation and intracellular activity of daptomycin towards phagocytized Staphylococcus aureus by the P-glycoprotein (MDR1) efflux transporter in human THP-1 macrophages and madin-darby canine kidney cells.
Antimicrobial agents and chemotherapy 2007;51(8):2748-57.
2007: Frédéric Mathot; André Schanck; Françoise Van Bambeke; Albertina Ariën; Mark Noppe; Marcus E Brewster; Véronique Préat
Passive diffusion of polymeric surfactants across lipid bilayers.
Journal of controlled release : official journal of the Controlled Release Society 2007;120(1-2):79-87.
2007: Narcisa Mesaros; patrice nordmann; Patrick Plésiat; Micheline Roussel-Delvallez; Johan Van Eldere; Y Glupczynski; Y Van Laethem; F Jacobs; Patrick LEBECQUE; Anne Malfroot; Paul Tulkens; Françoise Van Bambeke
Pseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2007;13(6):560-78.
2007: Sandrine Lemaire; Françoise Van Bambeke; Marie-Paule Mingeot-Leclercq; Youri Glupczynski; Paul Tulkens
Role of acidic pH in the susceptibility of intraphagocytic methicillin-resistant Staphylococcus aureus strains to meropenem and cloxacillin.
Antimicrobial agents and chemotherapy 2007;51(5):1627-32.
2007: Narcisa Mesaros; Youri Glupczynski; Laetitia Avrain; Nancy E Caceres; Paul Tulkens; Françoise Van Bambeke
A combined phenotypic and genotypic method for the detection of Mex efflux pumps in Pseudomonas aeruginosa.
The Journal of antimicrobial chemotherapy 2007;59(3):378-86.
2007: Pierre Baudoux; Nathalie Bles; Sandrine Lemaire; Marie-Paule Mingeot-Leclercq; Paul Tulkens; Françoise Van Bambeke
Combined effect of pH and concentration on the activities of gentamicin and oxacillin against Staphylococcus aureus in pharmacodynamic models of extracellular and intracellular infections.
The Journal of antimicrobial chemotherapy 2007;59(2):246-53.
2007: Françoise Van Bambeke; Ralf Rene Reinert; Peter C Appelbaum; Paul Tulkens; Willy E Peetermans
Multidrug-resistant Streptococcus pneumoniae infections: current and future therapeutic options.
Drugs 2007;67(16):2355-82.
2006: Maritza Barcia-Macay; Sandrine Lemaire; Marie-Paule Mingeot-Leclercq; Paul Tulkens; Françoise Van Bambeke
Evaluation of the extracellular and intracellular activities (human THP-1 macrophages) of telavancin versus vancomycin against methicillin-susceptible, methicillin-resistant, vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus.
The Journal of antimicrobial chemotherapy 2006;58(6):1177-84.
2006: Françoise Van Bambeke
Glycopeptides and glycodepsipeptides in clinical development: a comparative review of their antibacterial spectrum, pharmacokinetics and clinical efficacy.
Current opinion in investigational drugs (London, England : 2000) 2006;7(8):740-9.
2006: Françoise Van Bambeke; Jean-Marie Pagès; Ving J Lee
Inhibitors of bacterial efflux pumps as adjuvants in antibiotic treatments and diagnostic tools for detection of resistance by efflux.
Recent patents on anti-infective drug discovery 2006;1(2):157-75.
2006: Stéphane Vandevuer; Françoise Van Bambeke; Paul Tulkens; Martine Prévost
Predicting the three-dimensional structure of human P-glycoprotein in absence of ATP by computational techniques embodying crosslinking data: insight into the mechanism of ligand migration and binding sites.
Proteins 2006;63(3):466-78.
2006: Jean-Michel Michot; Marie F Heremans; Nancy E Caceres; Marie-Paule Mingeot-Leclercq; Paul Tulkens; Françoise Van Bambeke
Cellular accumulation and activity of quinolones in ciprofloxacin-resistant J774 macrophages.
Antimicrobial agents and chemotherapy 2006;50(5):1689-95.
2006: Hélène Servais; Yves Jossin; Françoise Van Bambeke; Paul Tulkens; Marie-Paule Mingeot-Leclercq
Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation.
Antimicrobial agents and chemotherapy 2006;50(4):1213-21.
2006: Françoise Van Bambeke; Maritza Barcia-Macay; Sandrine Lemaire; Paul Tulkens
Cellular pharmacodynamics and pharmacokinetics of antibiotics: current views and perspectives.
Current opinion in drug discovery & development 2006;9(2):218-30.
2006: Maritza Barcia-Macay; Cristina Seral; Marie-Paule Mingeot-Leclercq; Paul Tulkens; Françoise Van Bambeke
Pharmacodynamic evaluation of the intracellular activities of antibiotics against Staphylococcus aureus in a model of THP-1 macrophages.
Antimicrobial agents and chemotherapy 2006;50(3):841-51.
2006: Ekatherina Charvalos; Manolis N Tzatzarakis; Françoise Van Bambeke; Paul Tulkens; Aristidis M Tsatsakis; George N Tzanakakis; Marie-Paule Mingeot-Leclercq
Water-soluble amphotericin B-polyvinylpyrrolidone complexes with maintained antifungal activity against Candida spp. and Aspergillus spp. and reduced haemolytic and cytotoxic effects.
The Journal of antimicrobial chemotherapy 2006;57(2):236-44.
2005: Hélène Servais; Patrick Van Der Smissen; Gaëtan Thirion; Gauthier Van der Essen; Françoise Van Bambeke; Paul Tulkens; Marie-Paule Mingeot-Leclercq
Gentamicin-induced apoptosis in LLC-PK1 cells: involvement of lysosomes and mitochondria.
Toxicology and applied pharmacology 2005;206(3):321-33.
2005: Jean-Michel Michot; Cristina Seral; Françoise Van Bambeke; Marie-Paule Mingeot-Leclercq; Paul Tulkens
Influence of efflux transporters on the accumulation and efflux of four quinolones (ciprofloxacin, levofloxacin, garenoxacin, and moxifloxacin) in J774 macrophages.
Antimicrobial agents and chemotherapy 2005;49(6):2429-37.
2005: Sandrine Lemaire; Françoise Van Bambeke; Marie-Paule Mingeot-Leclercq; Paul Tulkens
Activity of three {beta}-lactams (ertapenem, meropenem and ampicillin) against intraphagocytic Listeria monocytogenes and Staphylococcus aureus.
The Journal of antimicrobial chemotherapy 2005;55(6):897-904.
2005: Françoise Van Bambeke; Jennifer Saffran; Marie-Paule Mingeot-Leclercq; Paul Tulkens
Mixed-lipid storage disorder induced in macrophages and fibroblasts by oritavancin (LY333328), a new glycopeptide antibiotic with exceptional cellular accumulation.
Antimicrobial agents and chemotherapy 2005;49(5):1695-700.
2005: Hugues Chanteux; Françoise Van Bambeke; Marie-Paule Mingeot-Leclercq; Paul Tulkens
Accumulation and oriented transport of ampicillin in Caco-2 cells from its pivaloyloxymethylester prodrug, pivampicillin.
Antimicrobial agents and chemotherapy 2005;49(4):1279-88.
2005: Françoise Van Bambeke; Jean-Michel Michot; J Van Eldere; Paul Tulkens
Quinolones in 2005: an update.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2005;11(4):256-80.
2005: Cristina Seral; Maritza Barcia-Macay; Marie-Paule Mingeot-Leclercq; Paul Tulkens; Françoise Van Bambeke
Comparative activity of quinolones (ciprofloxacin, levofloxacin, moxifloxacin and garenoxacin) against extracellular and intracellular infection by Listeria monocytogenes and Staphylococcus aureus in J774 macrophages.
The Journal of antimicrobial chemotherapy 2005;55(4):511-7.
2005: Jocelyne Piret; André Schanck; Sylvie Delfosse; Françoise Van Bambeke; Bellamkonda K Kishore; Paul Tulkens; Marie-Paule Mingeot-Leclercq
Modulation of the in vitro activity of lysosomal phospholipase A1 by membrane lipids.
Chemistry and physics of lipids 2005;133(1):1-15.
2004: Françoise Van Bambeke
Glycopeptides in clinical development: pharmacological profile and clinical perspectives.
Current opinion in pharmacology 2004;4(5):471-8.
2004: Françoise Van Bambeke; Stéphane Carryn; Cristina Seral; Hugues Chanteux; Donatienne Tyteca; Marie-Paule Mingeot-Leclercq; Paul Tulkens
Cellular pharmacokinetics and pharmacodynamics of the glycopeptide antibiotic oritavancin (LY333328) in a model of J774 mouse macrophages.
Antimicrobial agents and chemotherapy 2004;48(8):2853-60.
2004: Jean-Michel Michot; Françoise Van Bambeke; Marie-Paule Mingeot-Leclercq; Paul Tulkens
Active efflux of ciprofloxacin from J774 macrophages through an MRP-like transporter.
Antimicrobial agents and chemotherapy 2004;48(7):2673-82.
2004: Halim Ben Abdelaziz; Sandrine Lemaire; Stéphane Carryn; Françoise Van Bambeke; Marie-Paule Mingeot-Leclercq; Paul Tulkens
Inhibition of TNF-alpha production in THP-1 macrophages by glatiramer acetate does not alter their susceptibility to infection by Listeria monocytogenes and does not impair the efficacy of ampicillin or moxifloxacin against intracellular bacteria.
The Journal of antimicrobial chemotherapy 2004;54(1):288-9.
2004: Stéphane Carryn; Sébastien Van de Velde; Françoise Van Bambeke; Marie-Paule Mingeot-Leclercq; Paul Tulkens
Impairment of growth of Listeria monocytogenes in THP-1 macrophages by granulocyte macrophage colony-stimulating factor: release of tumor necrosis factor-alpha and nitric oxide.
The Journal of infectious diseases 2004;189(11):2101-9.
2004: Marie-Cécile Nassogne; Chantal Lizarraga; Francisca N'Kuli; Françoise Van Bambeke; Roger Van Binst; Pierre Wallemacq; Paul Tulkens; Marie-Paule Mingeot-Leclercq; Thierry Levade; Pierre J Courtoy
Cocaine induces a mixed lysosomal lipidosis in cultured fibroblasts, by inactivation of acid sphingomyelinase and inhibition of phospholipase A1.
Toxicology and applied pharmacology 2004;194(2):101-10.
2004: Françoise Van Bambeke; Yves Van Laethem; Patrice Courvalin; Paul Tulkens
Glycopeptide antibiotics: from conventional molecules to new derivatives.
Drugs 2004;64(9):913-36.
2003: Hugues Chanteux; Marie-Paule Mingeot-Leclercq; Etienne Sonveaux; Françoise Van Bambeke; Paul Tulkens
Intracellular accumulation and activity of ampicillin used as free drug and as its phthalimidomethyl or pivaloyloxymethyl ester (pivampicillin) against Listeria monocytogenes in J774 macrophages.
The Journal of antimicrobial chemotherapy 2003;52(4):610-5.
2003: Stéphane Carryn; Hugues Chanteux; Cristina Seral; Marie-Paule Mingeot-Leclercq; Françoise Van Bambeke; Paul Tulkens
Intracellular pharmacodynamics of antibiotics.
Infectious disease clinics of North America 2003;17(3):615-34.
2003: Cristina Seral; Françoise Van Bambeke; Paul Tulkens
Quantitative analysis of gentamicin, azithromycin, telithromycin, ciprofloxacin, moxifloxacin, and oritavancin (LY333328) activities against intracellular Staphylococcus aureus in mouse J774 macrophages.
Antimicrobial agents and chemotherapy 2003;47(7):2283-92.
2003: Cristina Seral; Stéphane Carryn; Paul Tulkens; Françoise Van Bambeke
Influence of P-glycoprotein and MRP efflux pump inhibitors on the intracellular activity of azithromycin and ciprofloxacin in macrophages infected by Listeria monocytogenes or Staphylococcus aureus.
The Journal of antimicrobial chemotherapy 2003;51(5):1167-73.
2003: Françoise Van Bambeke; Youri Glupczynski; Patrick Plésiat; Jean-Claude Pechère; Paul Tulkens
Antibiotic efflux pumps in prokaryotic cells: occurrence, impact on resistance and strategies for the future of antimicrobial therapy.
The Journal of antimicrobial chemotherapy 2003;51(5):1055-65.
2003: Françoise Van Bambeke; Jean-Michel Michot; Paul Tulkens
Antibiotic efflux pumps in eukaryotic cells: occurrence and impact on antibiotic cellular pharmacokinetics, pharmacodynamics and toxicodynamics.
The Journal of antimicrobial chemotherapy 2003;51(5):1067-77.
2003: Stéphane Carryn; Françoise Van Bambeke; Marie-Paule Mingeot-Leclercq; Paul Tulkens
Activity of beta-lactams (ampicillin, meropenem), gentamicin, azithromycin and moxifloxacin against intracellular Listeria monocytogenes in a 24 h THP-1 human macrophage model.
The Journal of antimicrobial chemotherapy 2003;51(4):1051-2.
2003: Cristina Seral; Jean-Michel Michot; Hugues Chanteux; Marie-Paule Mingeot-Leclercq; Paul Tulkens; Françoise Van Bambeke
Influence of P-glycoprotein inhibitors on accumulation of macrolides in J774 murine macrophages.
Antimicrobial agents and chemotherapy 2003;47(3):1047-51.
2003: Marie-Paule Mingeot-Leclercq; laurence lins; Mariam Bensliman; Annick Thomas; Françoise Van Bambeke; Jacques Peuvot; André Schanck; Robert Brasseur
Piracetam inhibits the lipid-destabilising effect of the amyloid peptide Abeta C-terminal fragment.
Biochimica et biophysica acta 2003;1609(1):28-38.
2002: Marie-Paule Mingeot-Leclercq; laurence lins; Mariam Bensliman; Françoise Van Bambeke; Patrick Van Der Smissen; Jacques Peuvot; André Schanck; Robert Brasseur
Membrane destabilization induced by beta-amyloid peptide 29-42: importance of the amino-terminus.
Chemistry and physics of lipids 2002;120(1-2):57-74.
2002: Donatienne Tyteca; Patrick Van Der Smissen; Marcel Mettlen; Françoise Van Bambeke; Paul Tulkens; Marie-Paule Mingeot-Leclercq; Pierre J Courtoy
Azithromycin, a lysosomotropic antibiotic, has distinct effects on fluid-phase and receptor-mediated endocytosis, but does not impair phagocytosis in J774 macrophages.
Experimental cell research 2002;281(1):86-100.
2002: Stéphane Carryn; Françoise Van Bambeke; Marie-Paule Mingeot-Leclercq; Paul Tulkens
Comparative intracellular (THP-1 macrophage) and extracellular activities of beta-lactams, azithromycin, gentamicin, and fluoroquinolones against Listeria monocytogenes at clinically relevant concentrations.
Antimicrobial agents and chemotherapy 2002;46(7):2095-103.
2001: Marie-Paule Mingeot-Leclercq; X Gallet; C Flore; Françoise Van Bambeke; Jacques Peuvot; Robert Brasseur
Experimental and conformational analyses of interactions between butenafine and lipids.
Antimicrobial agents and chemotherapy 2001;45(12):3347-54.
2001: Donatienne Tyteca; Patrick Van Der Smissen; Françoise Van Bambeke; K Leys; Paul Tulkens; Pierre J Courtoy; Marie-Paule Mingeot-Leclercq
Azithromycin, a lysosomotropic antibiotic, impairs fluid-phase pinocytosis in cultured fibroblasts.
European journal of cell biology 2001;80(7):466-78.
2001: Y Gholizadeh; Marie-Christine Prevost; Françoise Van Bambeke; B Casadewall; Paul Tulkens; Patrice Courvalin
Sequencing of the ddl gene and modeling of the mutated D-alanine:D-alanine ligase in glycopeptide-dependent strains of Enterococcus faecium.
Protein science : a publication of the Protein Society 2001;10(4):836-44.
2001: Françoise Van Bambeke; Paul Tulkens
Macrolides: pharmacokinetics and pharmacodynamics.
International journal of antimicrobial agents 2001;18 Suppl 1():S17-23.
2000: Françoise Van Bambeke; E Balzi; Paul Tulkens
Antibiotic efflux pumps.
Biochemical pharmacology 2000;60(4):457-70.
2000: M Prévost; D Van Belle; Paul Tulkens; P Courvalin; Françoise Van Bambeke
Modeling of Enterococcus faecalis D-alanine:D-alanine ligase: structure-based study of the active site in the wild-type enzyme and in glycopeptide-dependent mutants.
Journal of molecular microbiology and biotechnology 2000;2(3):321-30.
2000: Françoise Van Bambeke; A Kerkhofs; André Schanck; C Remacle; Etienne Sonveaux; Paul Tulkens; Marie-Paule Mingeot-Leclercq
Biophysical studies and intracellular destabilization of pH-sensitive liposomes.
Lipids 2000;35(2):213-23.
1999: J P Montenez; Françoise Van Bambeke; J Piret; Robert Brasseur; Paul Tulkens; Marie-Paule Mingeot-Leclercq
Interactions of macrolide antibiotics (Erythromycin A, roxithromycin, erythromycylamine [Dirithromycin], and azithromycin) with phospholipids: computer-aided conformational analysis and studies on acellular and cell culture models.
Toxicology and applied pharmacology 1999;156(2):129-40.
1999: Françoise Van Bambeke; M Chauvel; Peter E Reynolds; H S Fraimow; Patrice Courvalin
Vancomycin-dependent Enterococcus faecalis clinical isolates and revertant mutants.
Antimicrobial agents and chemotherapy 1999;43(1):41-7.
1998: Françoise Van Bambeke; C Gerbaux; Jean-Michel Michot; M B d'Yvoire; J P Montenez; Paul Tulkens
Lysosomal alterations induced in cultured rat fibroblasts by long-term exposure to low concentrations of azithromycin.
The Journal of antimicrobial chemotherapy 1998;42(6):761-7.
1996: J P Montenez; Françoise Van Bambeke; J Piret; André Schanck; Robert Brasseur; Paul Tulkens; Marie-Paule Mingeot-Leclercq
Interaction of the macrolide azithromycin with phospholipids. II. Biophysical and computer-aided conformational studies.
European journal of pharmacology 1996;314(1-2):215-27.
1996: Françoise Van Bambeke; J P Montenez; J Piret; Paul Tulkens; P J Courtoy; Marie-Paule Mingeot-Leclercq
Interaction of the macrolide azithromycin with phospholipids. I. Inhibition of lysosomal phospholipase A1 activity.
European journal of pharmacology 1996;314(1-2):203-14.
1996: C Gerbaux; Françoise Van Bambeke; J P Montenez; J Piret; G Morlighem; Paul Tulkens
Hyperactivity of cathepsin B and other lysosomal enzymes in fibroblasts exposed to azithromycin, a dicationic macrolide antibiotic with exceptional tissue accumulation.
FEBS letters 1996;394(3):307-10.
1996: Françoise Van Bambeke; Marie-Paule Mingeot-Leclercq; Robert Brasseur; Paul Tulkens; André Schanck
Aminoglycoside antibiotics prevent the formation of non-bilayer structures in negatively-charged membranes. Comparative studies using fusogenic (bis(beta-diethylaminoethylether)hexestrol) and aggregating (spermine) agents.
Chemistry and physics of lipids 1996;79(2):123-35.
1995: Françoise Van Bambeke; Paul Tulkens; Robert Brasseur; Marie-Paule Mingeot-Leclercq
Aminoglycoside antibiotics induce aggregation but not fusion of negatively-charged liposomes.
European journal of pharmacology 1995;289(2):321-33.
1993: Françoise Van Bambeke; Marie-Paule Mingeot-Leclercq; André Schanck; Robert Brasseur; Paul Tulkens
Alterations in membrane permeability induced by aminoglycoside antibiotics: studies on liposomes and cultured cells.
European journal of pharmacology 1993;247(2):155-68.