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victor kenyon

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Jessica R Weaver; Theodore R. Holman; Yumi Imai; Ajit Jadhav; victor kenyon; David J Maloney; Jerry L Nadler; Ganesha Rai; Anton Simeonov; David Taylor-Fishwick
Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction.
Jennifer Yeung; Patrick L Apopa; Olivier Boutaud; Theodore R. Holman; Ajit Jadhav; victor kenyon; David J Maloney; Ganesha Rai; Anton Simeonov; Joanne Vesci; Michael Holinstat
Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation.
victor kenyon; William Leister; David J Maloney; Jerry L Nadler; Steven Perry; Ganesha Rai; Lena Schultz; Anton Simeonov; David A Taylor-Fishwick; Michelle Armstrong; James M Bougie; Michael Holinstat; Ajit Jadhav; J Brian Jameson; Netra Joshi; Theodore R. Holman
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

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All Publications

2012: Jessica R Weaver; Theodore R. Holman; Yumi Imai; Ajit Jadhav; victor kenyon; David J Maloney; Jerry L Nadler; Ganesha Rai; Anton Simeonov; David Taylor-Fishwick
Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction.
Molecular and cellular endocrinology 2012;358(1):88-95.
2012: Jennifer Yeung; Patrick L Apopa; Olivier Boutaud; Theodore R. Holman; Ajit Jadhav; victor kenyon; David J Maloney; Ganesha Rai; Anton Simeonov; Joanne Vesci; Michael Holinstat
Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation.
Molecular pharmacology 2012;81(3):420-30.
2011: victor kenyon; William Leister; David J Maloney; Jerry L Nadler; Steven Perry; Ganesha Rai; Lena Schultz; Anton Simeonov; David A Taylor-Fishwick; Michelle Armstrong; James M Bougie; Michael Holinstat; Ajit Jadhav; J Brian Jameson; Netra Joshi; Theodore R. Holman
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.
Journal of medicinal chemistry 2011;54(15):5485-97.
2010: Ganesha Rai; victor kenyon; Ajit Jadhav; Lena Schultz; Michelle Armstrong; J Brian Jameson; Eric Hoobler; William Leister; Anton Simeonov; Theodore R Holman; David J Maloney
Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.
Journal of medicinal chemistry 2010;53(20):7392-404.
2009: Aaron T Wecksler; victor kenyon; Natalie K Garcia; Joshua D Deschamps; Wilfred Adrianus van der Donk; Theodore R. Holman
Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2.
Biochemistry 2009;48(36):8721-30.
2008: Aaron T Wecksler; victor kenyon; Joshua D Deschamps; Theodore R. Holman
Substrate specificity changes for human reticulocyte and epithelial 15-lipoxygenases reveal allosteric product regulation.
Biochemistry 2008;47(28):7364-75.
2008: Klaus Van Leyen; Ken Arai; Guang Jin; victor kenyon; Bettina Gerstner; Paul A Rosenberg; Theodore R. Holman; Eng H Lo
Novel lipoxygenase inhibitors as neuroprotective reagents.
Journal of neuroscience research 2008;86(4):904-9.
2007: Yesseny Vasquez-Martinez; Rachana V Ohri; victor kenyon; Theodore R. Holman; Silvia Sepúlveda-Boza
Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2.
Bioorganic & medicinal chemistry 2007;15(23):7408-25.
2006: Joshua D Deschamps; victor kenyon; Theodore R. Holman
Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases.
Bioorganic & medicinal chemistry 2006;14(12):4295-301.
2006: victor kenyon; Ilya Chorny; Wendy J Carvajal; Theodore R. Holman; Matthew P Jacobson
Novel human lipoxygenase inhibitors discovered using virtual screening with homology models.
Journal of medicinal chemistry 2006;49(4):1356-63.
2005: Robert H Cichewicz; Laura J Clifford; Peter R Lassen; Xiaolin Cao; Teresa B Freedman; Laurence A Nafie; Joshua D Deschamps; victor kenyon; Jocelyn R Flanary; Theodore R. Holman; Phillip Crews
Stereochemical determination and bioactivity assessment of (S)-(+)-curcuphenol dimers isolated from the marine sponge Didiscus aceratus and synthesized through laccase biocatalysis.
Bioorganic & medicinal chemistry 2005;13(19):5600-12.
2004: Robert H Cichewicz; victor kenyon; Stephanie Whitman; Nancy M Morales; Joanne F Arguello; Theodore R. Holman; Phillip Crews
Redox inactivation of human 15-lipoxygenase by marine-derived meroditerpenes and synthetic chromanes: archetypes for a unique class of selective and recyclable inhibitors.
Journal of the American Chemical Society 2004;126(45):14910-20.
2004: Viola Ruddat; Rakesh Mogul; Ilya Chorny; Cameron Chen; Noah Perrin; Stephanie Whitman; victor kenyon; Matthew P Jacobson; Claude F Bernasconi; Theodore R. Holman
Tryptophan 500 and arginine 707 define product and substrate active site binding in soybean lipoxygenase-1.
Biochemistry 2004;43(41):13063-71.
2004: Erika N Segraves; Rachana R Shah; Nathaniel L Segraves; Tyler A Johnson; Stephanie Whitman; Jennifer K Sui; victor kenyon; Robert H Cichewicz; Phillip Crews; Theodore R. Holman
Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase.
Journal of medicinal chemistry 2004;47(16):4060-5.