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Maria Castro
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104
Lowenstein, Pedro
24
Kroeger, Kurt
24
Candolfi, Marianela
23
Liu, Chunyan
17
Curtin, James
15
Linton, EA
15
King, Gwendalyn
15
Xiong, Weidong
14
Puntel, Mariana
14
Barcia, Carlos
13
Southgate, Thomas
10
Perone, Marcelo
10
Löwenstein, Pedro
9
Lowry, Philip
8
Smith-Arica, JR
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All Publications
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2009: Candolfi Marianela; Kroeger Kurt M; Muhammad A K M G; Yagiz Kader; Farrokhi Catherine; Pechnick Robert N; Lowenstein Pedro R; Castro Maria G
Gene therapy for brain cancer: combination therapies provide enhanced efficacy and safety.
Current gene therapy 2009;9(5):409-21.
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2009: Lowenstein Pedro R; Castro Maria G
Uncertainty in the translation of preclinical experiments to clinical trials. Why do most phase III clinical trials fail?
Current gene therapy 2009;9(5):368-74.
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2009: Castro Maria G; Lowenstein Pedro R
Gene therapy continues to make progress: clinical and regulatory perspectives.
Current gene therapy 2009;9(5):327-8.
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2009: Lowenstein Pedro R; Lowenstein Elijah D; Castro Maria G
Challenges in the evaluation, consent, ethics and history of early clinical trials - Implications of the Tuskegee 'trial' for safer and more ethical clinical trials.
Current opinion in molecular therapeutics 2009;11(5):481-4.
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2009: Ghulam Muhammad A K M; Candolfi Marianela; King Gwendalyn D; Yagiz Kader; Foulad David; Mineharu Yohei; Kroeger Kurt M; Treuer Katherine A; Nichols W Stephen; Sanderson Nicholas S; Yang Jieping; Khayznikov Maksim; Van Rooijen Nico; Lowenstein Pedro R; Castro Maria G
Antiglioma immunological memory in response to conditional cytotoxic/immune-stimulatory gene therapy: humoral and cellular immunity lead to tumor regression.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(19):6113-27.
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2009: Candolfi Marianela; Yagiz Kader; Foulad David; Alzadeh Gabrielle E; Tesarfreund Matthew; Muhammad A K M Ghulam; Puntel Mariana; Kroeger Kurt M; Liu Chunyan; Lee Sharon; Curtin James F; King Gwendalyn D; Lerner Jonathan; Sato Katsuaki; Mineharu Yohei; Xiong Weidong; Lowenstein Pedro R; Castro Maria G
Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(13):4401-14.
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2009: Puntel M; Barrett R J; Mondkar S; Saxena V; Kroeger K M; Muhammad A K M; Liu C; Bondale N; Sciascia S; Xiong W; Shi Y; Salem A; Zadmehr A; Huynh P; Palmer D; Ng P; Castro M G; Lowenstein P R
Herpes simplex virus type 1 thymidine kinase sequence fused to the lacz gene increases levels of {beta}-galactosidase activity per genome of high-capacity but not first-generation adenoviral vectors in vitro and in vivo.
Journal of virology 2009;83(4):2004-10.
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2009: Curtin James F; Liu Naiyou; Candolfi Marianela; Xiong Weidong; Assi Hikmat; Yagiz Kader; Edwards Matthew R; Michelsen Kathrin S; Kroeger Kurt M; Liu Chunyan; Muhammad A K M Ghulam; Clark Mary C; Arditi Moshe; Comin-Anduix Begonya; Ribas Antoni; Lowenstein Pedro R; Castro Maria G
HMGB1 mediates endogenous TLR2 activation and brain tumor regression.
PLoS medicine 2009;6(1):e10.
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2008: Southgate Thomas; Kroeger Kurt M; Liu Chunyan; Lowenstein Pedro R; Castro Maria G
Gene transfer into neural cells in vitro using adenoviral vectors.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2008;Chapter 4():Unit 4.23.
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2008: King Gwendalyn D; Muhammad A K M Ghulam; Xiong Weidong; Kroeger Kurt M; Puntel Mariana; Larocque Daniel; Palmer Donna; Ng Philip; Lowenstein Pedro R; Castro Maria G
High-capacity adenovirus vector-mediated anti-glioma gene therapy in the presence of systemic antiadenovirus immunity.
Journal of virology 2008;82(9):4680-4.
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2008: King Gwendalyn D; Kroeger Kurt M; Bresee Catherine J; Candolfi Marianela; Liu Chunyan; Manalo Charlene M; Muhammad A K M Ghulam; Pechnick Robert N; Lowenstein Pedro R; Castro Maria G
Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain tumor-induced behavioral deficits.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(4):682-90.
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2008: Barcia Carlos; Wawrowsky Kolja; Barrett Robert J; Liu Chunyan; Castro Maria G; Lowenstein Pedro R
In vivo polarization of IFN-gamma at Kupfer and non-Kupfer immunological synapses during the clearance of virally infected brain cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(3):1344-52.
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2008: Xiong Weidong; Candolfi Marianela; Kroeger Kurt M; Puntel Mariana; Mondkar Sonali; Larocque Daniel; Liu Chunyan; Curtin James F; Palmer Donna; Ng Philip; Lowenstein Pedro R; Castro Maria G
Immunization against the transgene but not the TetON switch reduces expression from gutless adenoviral vectors in the brain.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(2):343-51.
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2008: King Gwendalyn D; Muhammad A K M Ghulam; Curtin James F; Barcia Carlos; Puntel Mariana; Liu Chunyan; Honig Sarah B; Candolfi Marianela; Mondkar Sonali; Lowenstein Pedro R; Castro Maria G
Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model.
Neuro-oncology 2008;10(1):19-31.
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2008: Barcia Carlos; Sanderson Nicholas S R; Barrett Robert J; Wawrowsky Kolja; Kroeger Kurt M; Puntel Mariana; Liu Chunyan; Castro Maria G; Lowenstein Pedro R
T cells' immunological synapses induce polarization of brain astrocytes in vivo and in vitro: a novel astrocyte response mechanism to cellular injury.
PloS one 2008;3(8):e2977.
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2008: Curtin James F; Candolfi Marianela; Fakhouri Tamer M; Liu Chunyan; Alden Anderson; Edwards Matthew; Lowenstein Pedro R; Castro Maria G
Treg depletion inhibits efficacy of cancer immunotherapy: implications for clinical trials.
PloS one 2008;3(4):e1983.
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2007: Barcia Carlos; Jimenez-Dalmaroni Maximiliano; Kroeger Kurt M; Puntel Mariana; Rapaport Alison J; Larocque Daniel; King Gwendalyn D; Johnson Stephen A; Liu Chunyan; Xiong Weidong; Candolfi Marianela; Mondkar Sonali; Ng Philip; Palmer Donna; Castro Maria G; Lowenstein Pedro R
One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(12):2154-63.
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2007: Candolfi Marianela; Curtin James F; Nichols W Stephen; Muhammad Akm G; King Gwendalyn D; Pluhar G Elizabeth; McNiel Elizabeth A; Ohlfest John R; Freese Andrew B; Moore Peter F; Lerner Jonathan; Lowenstein Pedro R; Castro Maria G
Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression.
Journal of neuro-oncology 2007;85(2):133-48.
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2007: Lowenstein Pedro R; Mandel Ronald J; Xiong Wei-Dong; Kroeger Kurt; Castro Maria G
Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions.
Current gene therapy 2007;7(5):347-60.
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2007: Lowenstein Pedro R; Kroeger Kurt; Castro Maria G
Immunology of neurological gene therapy: how T cells modulate viral vector-mediated therapeutic transgene expression through immunological synapses.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2007;4(4):715-24.
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2007: Oh Seunguk; Odland Rick; Wilson Scott R; Kroeger Kurt M; Liu Chunyan; Lowenstein Pedro R; Castro Maria G; Hall Walter A; Ohlfest John R
Improved distribution of small molecules and viral vectors in the murine brain using a hollow fiber catheter.
Journal of neurosurgery 2007;107(3):568-77.
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2007: Oh Seunguk; Pluhar G Elizabeth; McNeil Elizabeth A; Kroeger Kurt M; Liu Chunyan; Castro Maria G; Lowenstein Pedro R; Freese Andrew; Ohlfest John R
Efficacy of nonviral gene transfer in the canine brain.
Journal of neurosurgery 2007;107(1):136-44.
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2007: Candolfi Marianela; Pluhar G Elizabeth; Kroeger Kurt; Puntel Mariana; Curtin James; Barcia Carlos; Muhammad A K M Ghulam; Xiong Weidong; Liu Chunyan; Mondkar Sonali; Kuoy William; Kang Terry; McNeil Elizabeth A; Freese Andrew B; Ohlfest John R; Moore Peter; Palmer Donna; Ng Phillip; Young John D; Lowenstein Pedro R; Castro Maria G
Optimization of adenoviral vector-mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro.
Neuro-oncology 2007;9(3):245-58.
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2007: Candolfi Marianela; Kroeger Kurt M; Pluhar G Elizabeth; Bergeron Josee; Puntel Mariana; Curtin James F; McNiel Elizabeth A; Freese Andrew B; Ohlfest John R; Moore Peter; Lowenstein Pedro R; Castro Maria G
Adenoviral-mediated gene transfer into the canine brain in vivo.
Neurosurgery 2007;60(1):167-77; discussion 178.
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2006: Barcia Carlos; Gerdes Christian; Xiong Wei-Dong; Thomas Clare E; Liu Chunyan; Kroeger Kurt M; Castro Maria G; Lowenstein Pedro R
Immunological thresholds in neurological gene therapy: highly efficient elimination of transduced cells might be related to the specific formation of immunological synapses between T cells and virus-infected brain cells.
Neuron glia biology 2006;2(4):309-22.
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2006: Barcia Carlos; Thomas Clare E; Curtin James F; King Gwendalyn D; Wawrowsky Kolja; Candolfi Marianela; Xiong Wei-Dong; Liu Chunyan; Kroeger Kurt; Boyer Olivier; Kupiec-Weglinski Jerzy; Klatzmann David; Castro Maria G; Lowenstein Pedro R
In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain.
The Journal of experimental medicine 2006;203(9):2095-107.
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2006: Candolfi Marianela; Curtin James F; Xiong Wei-Dong; Kroeger Kurt M; Liu Chunyan; Rentsendorj Altan; Agadjanian Hasmik; Medina-Kauwe Lali; Palmer Donna; Ng Philip; Lowenstein Pedro R; Castro Maria G
Effective high-capacity gutless adenoviral vectors mediate transgene expression in human glioma cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(3):371-81.
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2006: Candolfi M; Jaita G; Pisera D; Ferrari L; Barcia C; Liu C; Yu J; Liu G; Castro M G; Seilicovich A
Adenoviral vectors encoding tumor necrosis factor-alpha and FasL induce apoptosis of normal and tumoral anterior pituitary cells.
The Journal of endocrinology 2006;189(3):681-90.
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2006: Puntel M; Curtin J F; Zirger J M; Muhammad A K M; Xiong W; Liu C; Hu J; Kroeger K M; Czer P; Sciascia S; Mondkar S; Lowenstein P R; Castro M G
Quantification of high-capacity helper-dependent adenoviral vector genomes in vitro and in vivo, using quantitative TaqMan real-time polymerase chain reaction.
Human gene therapy 2006;17(5):531-44.
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2006: Curtin James F; King Gwendalyn D; Barcia Carlos; Liu Chunyan; Hubert François X; Guillonneau Carole; Josien Régis; Anegon Ignacio; Lowenstein Pedro R; Castro Maria G
Fms-like tyrosine kinase 3 ligand recruits plasmacytoid dendritic cells to the brain.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(6):3566-77.
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2006: Xiong Weidong; Goverdhana Shyam; Sciascia Sandra A; Candolfi Marianela; Zirger Jeffrey M; Barcia Carlos; Curtin James F; King Gwendalyn D; Jaita Gabriela; Liu Chunyan; Kroeger Kurt; Agadjanian Hasmik; Medina-Kauwe Lali; Palmer Donna; Ng Philip; Lowenstein Pedro R; Castro Maria G
Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses.
Journal of virology 2006;80(1):27-37.
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2006: Zirger Jeffrey M; Liu Chunyan; Barcia Carlos; Castro Maria G; Lowenstein Pedro R
Immune regulation of transgene expression in the brain: B cells regulate an early phase of elimination of transgene expression from adenoviral vectors.
Viral immunology 2006;19(3):508-17.
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2005: Seilicovich Adriana; Pisera Daniel; Sciascia Sandra A; Candolfi Marianela; Puntel Mariana; Xiong Weidong; Jaita Gabriela; Castro Maria G
Gene therapy for pituitary tumors.
Current gene therapy 2005;5(6):559-72.
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2005: King Gwendalyn D; Curtin James F; Candolfi Marianela; Kroeger Kurt; Lowenstein Pedro R; Castro Maria G
Gene therapy and targeted toxins for glioma.
Current gene therapy 2005;5(6):535-57.
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2005: Jaita G; Candolfi M; Zaldivar V; Zárate S; Ferrari L; Pisera D; Castro M G; Seilicovich A
Estrogens up-regulate the Fas/FasL apoptotic pathway in lactotropes.
Endocrinology 2005;146(11):4737-44.
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2005: Ali Sumia; King Gwendalyn D; Curtin James F; Candolfi Marianela; Xiong Weidong; Liu Chunyan; Puntel Mariana; Cheng Queng; Prieto Jesus; Ribas Antoni; Kupiec-Weglinski Jerzy; van Rooijen Nico; Lassmann Hans; Lowenstein Pedro R; Castro Maria G
Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.
Cancer research 2005;65(16):7194-204.
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2005: Goverdhana S; Puntel M; Xiong W; Zirger J M; Barcia C; Curtin J F; Soffer E B; Mondkar S; King G D; Hu J; Sciascia S A; Candolfi M; Greengold D S; Lowenstein P R; Castro M G
Regulatable gene expression systems for gene therapy applications: progress and future challenges.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(2):189-211.
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2005: Abordo-Adesida Evelyn; Follenzi Antonia; Barcia Carlos; Sciascia Sandra; Castro Maria G; Naldini Luigi; Lowenstein Pedro R
Stability of lentiviral vector-mediated transgene expression in the brain in the presence of systemic antivector immune responses.
Human gene therapy 2005;16(6):741-51.
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2005: Candolfi M; Jaita G; Zaldivar V; Zárate S; Ferrari L; Pisera D; Castro M G; Seilicovich A
Progesterone antagonizes the permissive action of estradiol on tumor necrosis factor-alpha-induced apoptosis of anterior pituitary cells.
Endocrinology 2005;146(2):736-43.
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2005: Curtin James F; King Gwendalyn D; Candolfi Marianela; Greeno Remy B; Kroeger Kurt M; Lowenstein Pedro R; Castro Maria G
Combining cytotoxic and immune-mediated gene therapy to treat brain tumors.
Current topics in medicinal chemistry 2005;5(12):1151-70.
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2004: Suwelack D; Hurtado-Lorenzo A; Millan E; Gonzalez-Nicolini V; Wawrowsky K; Lowenstein P R; Castro M G
Neuronal expression of the transcription factor Gli1 using the Talpha1 alpha-tubulin promoter is neuroprotective in an experimental model of Parkinson's disease.
Gene therapy 2004;11(24):1742-52.
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2004: Ali Sumia; Curtin James F; Zirger Jeffrey M; Xiong Weidong; King Gwendalyn D; Barcia Carlos; Liu Chunyan; Puntel Mariana; Goverdhana Shyam; Lowenstein Pedro R; Castro Maria G
Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L): treatment with hsFlt3L inhibits intracranial glioma progression.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(6):1071-84.
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2004: Biglari Alireza; Bataille Dominique; Naumann Ulrike; Weller Michael; Zirger Jeffrey; Castro Maria G; Lowenstein Pedro R
Effects of ectopic decorin in modulating intracranial glioma progression in vivo, in a rat syngeneic model.
Cancer gene therapy 2004;11(11):721-32.
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2004: Pisera D; Candolfi M; Navarra S; Ferraris J; Zaldivar V; Jaita G; Castro M G; Seilicovich A
Estrogens sensitize anterior pituitary gland to apoptosis.
American journal of physiology. Endocrinology and metabolism 2004;287(4):E767-71.
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2004: Hurtado-Lorenzo A; Millan E; Gonzalez-Nicolini V; Suwelack D; Castro M G; Lowenstein P R
Differentiation and transcription factor gene therapy in experimental parkinson's disease: sonic hedgehog and Gli-1, but not Nurr-1, protect nigrostriatal cell bodies from 6-OHDA-induced neurodegeneration.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(3):507-24.
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2004: Ke Bibo; Shen Xiu-Da; Gao Feng; Busuttil Ronald W; Löwenstein Pedro R; Castro Maria G; Kupiec-Weglinski Jerzy W
Gene therapy for liver transplantation using adenoviral vectors: CD40-CD154 blockade by gene transfer of CD40Ig protects rat livers from cold ischemia and reperfusion injury.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(1):38-45.
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2003: Kingston Paul A; Sinha Sanjay; Appleby Clare E; David Anne; Verakis Thomas; Castro Maria G; Lowenstein Pedro R; Heagerty Anthony M
Adenovirus-mediated gene transfer of transforming growth factor-beta3, but not transforming growth factor-beta1, inhibits constrictive remodeling and reduces luminal loss after coronary angioplasty.
Circulation 2003;108(22):2819-25.
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2003: Stone Daniel; Xiong Weidong; Williams Judith C; David Anne; Lowenstein Pedro R; Castro Maria G
Adenovirus expression of IL-1 and NF-kappaB inhibitors does not inhibit acute adenoviral-induced brain inflammation, but delays immune system-mediated elimination of transgene expression.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(3):400-11.
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2003: Appleby C E; Kingston P A; David A; Gerdes C A; Umaña P; Castro M G; Lowenstein P R; Heagerty A M
A novel combination of promoter and enhancers increases transgene expression in vascular smooth muscle cells in vitro and coronary arteries in vivo after adenovirus-mediated gene transfer.
Gene therapy 2003;10(18):1616-22.
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2003: Stirland J A; Seymour Z C; Windeatt S; Norris A J; Stanley P; Castro M G; Loudon A S I; White M R H; Davis J R E
Real-time imaging of gene promoter activity using an adenoviral reporter construct demonstrates transcriptional dynamics in normal anterior pituitary cells.
The Journal of endocrinology 2003;178(1):61-9.
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2003: Lowenstein P R; Castro M G
Inflammation and adaptive immune responses to adenoviral vectors injected into the brain: peculiarities, mechanisms, and consequences.
Gene therapy 2003;10(11):946-54.
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2003: Castro M G; Cowen R; Williamson I K; David A; Jimenez-Dalmaroni M J; Yuan X; Bigliari A; Williams J C; Hu J; Lowenstein P R
Current and future strategies for the treatment of malignant brain tumors.
Pharmacology & therapeutics 2003;98(1):71-108.
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2003: Guillot Cecile; Ménoret Séverine; Guillonneau Carole; Braudeau Cécile; Castro Maria G; Lowenstein Pedro; Anegon Ignacio
Active suppression of allogeneic proliferative responses by dendritic cells after induction of long-term allograft survival by CTLA4Ig.
Blood 2003;101(8):3325-33.
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2003: Lowenstein Pedro R; Suwelack Donata; Hu Jinwei; Yuan Xianpeng; Jimenez-Dalmaroni Maximiliano; Goverdhana Shyam; Castro Maria G
Nonneurotropic adenovirus: a vector for gene transfer to the brain and gene therapy of neurological disorders.
International review of neurobiology 2003;55():3-64.
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2003: Hurtado-Lorenzo Andres; David Anne; Thomas Clare; Castro Maria G; Lowenstein Pedro R
Use of recombinant adenovirus for gene transfer into the rat brain. Evaluation of gene transfer efficiency, toxicity, and inflammatory and immune reactions.
Methods in molecular medicine 2003;76():113-33.
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2002: Cowen Rachel L; Williams Judith C; Emery Steve; Blakey David; Darling John L; Lowenstein Pedro R; Castro Maria G
Adenovirus vector-mediated delivery of the prodrug-converting enzyme carboxypeptidase G2 in a secreted or GPI-anchored form: High-level expression of this active conditional cytotoxic enzyme at the plasma membrane.
Cancer gene therapy 2002;9(11):897-907.
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2002: Grande-Pérez A; Sierra S; Castro M G; Domingo E; Lowenstein P R
Molecular indetermination in the transition to error catastrophe: systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):12938-43.
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2002: Davis J R E; McMahon R F T; Lowenstein P R; Castro M G; Lincoln G A; McNeilly A S
Adenovirus-mediated gene transfer in the ovine pituitary gland is associated with hypophysitis.
The Journal of endocrinology 2002;173(2):265-71.
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2002: Thomas Clare E; Edwards Penny; Wickham Thomas J; Castro Maria G; Lowenstein Pedro R
Adenovirus binding to the coxsackievirus and adenovirus receptor or integrins is not required to elicit brain inflammation but is necessary to transduce specific neural cell types.
Journal of virology 2002;76(7):3452-60.
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2002: Guillot Cécile; Guillonneau Carole; Mathieu Patrick; Gerdes Christian A; Ménoret Séverine; Braudeau Cécile; Tesson Laurent; Renaudin Karine; Castro Maria G; Löwenstein Pedro R; Anegon Ignacio
Prolonged blockade of CD40-CD40 ligand interactions by gene transfer of CD40Ig results in long-term heart allograft survival and donor-specific hyporesponsiveness, but does not prevent chronic rejection.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1600-9.
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2002: Mohammad Y N; Perone M; Wang L; Ingleton P M; Castro M G; Lovejoy D A
Expression of prolactin receptors and regulation of cell proliferation by prolactin, corticotropin-releasing factor, and corticosterone in a neuroblastoma cell line.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2002;80(4):475-82.
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2002: Lowenstein P R; Thomas C E; Umana P; Gerdes C A; Verakis T; Boyer O; Tondeur S; Klatzmann D; Castro M G
High-capacity, helper-dependent, "gutless" adenoviral vectors for gene transfer into brain.
Methods in enzymology 2002;346():292-311.
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2001: Williams J C; Stone D; Smith-Arica J R; Morris I D; Lowenstein P R; Castro M G
Regulated, adenovirus-mediated delivery of tyrosine hydroxylase suppresses growth of estrogen-induced pituitary prolactinomas.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;4(6):593-602.
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2001: Kingston P A; Sinha S; David A; Castro M G; Lowenstein P R; Heagerty A M
Adenovirus-mediated gene transfer of a secreted transforming growth factor-beta type II receptor inhibits luminal loss and constrictive remodeling after coronary angioplasty and enhances adventitial collagen deposition.
Circulation 2001;104(21):2595-601.
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2001: Zermansky A J; Bolognani F; Stone D; Cowsill C M; Morrissey G; Castro M G; Löwenstein P R
Towards global and long-term neurological gene therapy: unexpected transgene dependent, high-level, and widespread distribution of HSV-1 thymidine kinase throughout the CNS.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;4(5):490-8.
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2001: Castro M G; David A; Hurtado-Lorenzo A; Suwelack D; Millan E; Verakis T; Xiong W D; Yuan X P; Lowenstein P R
Gene therapy for Parkinson's disease: recent achievements and remaining challenges.
Histology and histopathology 2001;16(4):1225-38.
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2001: Maleniak T C; Darling J L; Lowenstein P R; Castro M G
Adenovirus-mediated expression of HSV1-TK or Fas ligand induces cell death in primary human glioma-derived cell cultures that are resistant to the chemotherapeutic agent CCNU.
Cancer gene therapy 2001;8(8):589-98.
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2001: Umaña P; Gerdes C A; Stone D; Davis J R; Ward D; Castro M G; Lowenstein P R
Efficient FLPe recombinase enables scalable production of helper-dependent adenoviral vectors with negligible helper-virus contamination.
Nature biotechnology 2001;19(6):582-5.
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2001: Smith-Arica J R; Williams J C; Stone D; Smith J; Lowenstein P R; Castro M G
Switching on and off transgene expression within lactotrophic cells in the anterior pituitary gland in vivo.
Endocrinology 2001;142(6):2521-32.
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2001: Southgate T D; Kingston P A; Castro M G
Gene transfer into neural cells in vitro using adenoviral vectors.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2001;Chapter 4():Unit 4.23.
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2001: Thomas C E; Schiedner G; Kochanek S; Castro M G; Lowenstein P R
Preexisting antiadenoviral immunity is not a barrier to efficient and stable transduction of the brain, mediated by novel high-capacity adenovirus vectors.
Human gene therapy 2001;12(7):839-46.
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2001: Castro M G; Southgate T; Lowenstein P R
Molecular therapy in a model neuroendocrine disease: developing clinical gene therapy for pituitary tumours.
Trends in endocrinology and metabolism: TEM 2001;12(2):58-64.
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2001: Stirland J A; Johnston J D; Cagampang F R; Morgan P J; Castro M G; White M R; Davis J R; Loudon A S
Photoperiodic regulation of prolactin gene expression in the Syrian hamster by a pars tuberalis-derived factor.
Journal of neuroendocrinology 2001;13(2):147-57.
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2001: Davis J R; McVerry J; Lincoln G A; Windeatt S; Lowenstein P R; Castro M G; McNeilly A S
Cell type-specific adenoviral transgene expression in the intact ovine pituitary gland after stereotaxic delivery: an in vivo system for long-term multiple parameter evaluation of human pituitary gene therapy.
Endocrinology 2001;142(2):795-801.
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2001: Thomas C E; Birkett D; Anozie I; Castro M G; Lowenstein P R
Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;3(1):36-46.
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2001: Southgate T D; Stone D; Williams J C; Lowenstein P R; Castro M G
Long-term transgene expression within the anterior pituitary gland in situ: impact on circulating hormone levels, cellular and antibody-mediated immune responses.
Endocrinology 2001;142(1):464-76.
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2000: Smith-Arica J R; Morelli A E; Larregina A T; Smith J; Lowenstein P R; Castro M G
Cell-type-specific and regulatable transgenesis in the adult brain: adenovirus-encoded combined transcriptional targeting and inducible transgene expression.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;2(6):579-87.
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2000: Brown O; Cowen R L; Preston C M; Castro M G; Lowenstein P R
Subcellular post-transcriptional targeting: delivery of an intracellular protein to the extracellular leaflet of the plasma membrane using a glycosyl-phosphatidylinositol (GPI) membrane anchor in neurons and polarised epithelial cells.
Gene therapy 2000;7(22):1947-53.
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2000: Gerdes C A; Castro M G; Löwenstein P R
Strong promoters are the key to highly efficient, noninflammatory and noncytotoxic adenoviral-mediated transgene delivery into the brain in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;2(4):330-8.
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2000: Castro M G; Cowen R; Smith-Arica J; Williams J; Ali S; Windeatt S; Gonzalez-Nicolini V; Maleniak T; Lowenstein P R
Gene therapy strategies for intracranial tumours: glioma and pituitary adenomas.
Histology and histopathology 2000;15(4):1233-52.
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2000: Southgate T D; Windeatt S; Smith-Arica J; Gerdes C A; Perone M J; Morris I; Davis J R; Klatzmann D; Löwenstein P R; Castro M G
Transcriptional targeting to anterior pituitary lactotrophic cells using recombinant adenovirus vectors in vitro and in vivo in normal and estrogen/sulpiride-induced hyperplastic anterior pituitaries.
Endocrinology 2000;141(9):3493-505.
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2000: Carrington L M; Southgate T; Saxby L A; Abul-Hassan K; Maleniak T C; Castro M G; Boulton M E
Adenovirus-mediated gene transfer to human lens epithelial cells in organ culture.
Journal of cataract and refractive surgery 2000;26(6):887-92.
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2000: Thomas C E; Schiedner G; Kochanek S; Castro M G; Löwenstein P R
Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: toward realistic long-term neurological gene therapy for chronic diseases.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7482-7.
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2000: Guillot C; Mathieu P; Coathalem H; Le Mauff B; Castro M G; Tesson L; Usal C; Laumonier T; Brouard S; Soulillou J P; Lowenstein P R; Cuturi M C; Anegon I
Tolerance to cardiac allografts via local and systemic mechanisms after adenovirus-mediated CTLA4Ig expression.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(10):5258-68.
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2000: Cowsill C; Southgate T D; Morrissey G; Dewey R A; Morelli A E; Maleniak T C; Forrest Z; Klatzmann D; Wilkinson G W; Löwenstein P R; Castro M G
Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase: reduced cytotoxicity of a truncated HSV1-TK.
Gene therapy 2000;7(8):679-85.
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2000: Windeatt S; Southgate T D; Dewey R A; Bolognani F; Perone M J; Larregina A T; Maleniak T C; Morris I D; Goya R G; Klatzmann D; Löwenstein P R; Castro M G
Adenovirus-mediated herpes simplex virus type-1 thymidine kinase gene therapy suppresses oestrogen-induced pituitary prolactinomas.
The Journal of clinical endocrinology and metabolism 2000;85(3):1296-305.
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2000: Ahmed I; Glynn B P; Perkins A V; Castro M G; Rowe J; Morrison E; Linton E A
Processing of procorticotropin-releasing hormone (pro-CRH): molecular forms of CRH in normal and preeclamptic pregnancy.
The Journal of clinical endocrinology and metabolism 2000;85(2):755-64.
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2000: Stone D; David A; Bolognani F; Lowenstein P R; Castro M G
Viral vectors for gene delivery and gene therapy within the endocrine system.
The Journal of endocrinology 2000;164(2):103-18.
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1999: Southgate T D; Bain D; Fairbanks L D; Morelli A E; Larregina A T; Simmonds H A; Castro M G; Löwenstein P R
Adenoviruses encoding HPRT correct biochemical abnormalities of HPRT-deficient cells and allow their survival in negative selection medium.
Metabolic brain disease 1999;14(4):205-21.
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1999: Lowenstein P R; Cowen R; Thomas C; Castro M G
The basic science of brain-tumour gene therapy.
Biochemical Society transactions 1999;27(6):873-81.
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1999: Castro M G; Windeatt S; Smith-Arica J; Lowenstein P R
Cell-type specific expression in the pituitary: physiology and gene therapy.
Biochemical Society transactions 1999;27(6):858-63.
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1999: Tomasec P; Preston C M; Linton E A; Ahmed I; Lowenstein P R; Castro M G
Generation of a recombinant herpes simplex virus type 1 expressing the rat corticotropin- releasing hormone precursor: endoproteolytic processing, intracellular targeting and biological activity.
Neuroendocrinology 1999;70(6):439-50.
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1999: Dewey R A; Morrissey G; Cowsill C M; Stone D; Bolognani F; Dodd N J; Southgate T D; Klatzmann D; Lassmann H; Castro M G; Löwenstein P R
Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials.
Nature medicine 1999;5(11):1256-63.
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1999: Castro M G; Davis J R; Xiong W; Lowenstein P R
Recent developments in gene therapy: applications for the treatment of pituitary tumours.
Baillière's best practice & research. Clinical endocrinology & metabolism 1999;13(3):431-49.
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1999: Ambar B B; Frei K; Malipiero U; Morelli A E; Castro M G; Lowenstein P R; Fontana A
Treatment of experimental glioma by administration of adenoviral vectors expressing Fas ligand.
Human gene therapy 1999;10(10):1641-8.
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1999: Lowenstein P R; Thomas C E; Castro M G
Politically correct gene therapy? A "clean environment" improves gene delivery to the brain!
Gene therapy 1999;6(4):463-4.
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1999: Morelli A E; Larregina A T; Smith-Arica J; Dewey R A; Southgate T D; Ambar B; Fontana A; Castro M G; Lowenstein P R
Neuronal and glial cell type-specific promoters within adenovirus recombinants restrict the expression of the apoptosis-inducing molecule Fas ligand to predetermined brain cell types, and abolish peripheral liver toxicity.
The Journal of general virology 1999;80 ( Pt 3)():571-83.
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1999: Cartmell T; Southgate T; Rees G S; Castro M G; Lowenstein P R; Luheshi G N
Interleukin-1 mediates a rapid inflammatory response after injection of adenoviral vectors into the brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(4):1517-23.
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1999: Castro M G
Gene therapy strategies for the treatment of pituitary tumours.
Journal of molecular endocrinology 1999;22(1):9-18.
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1998: Tellam D J; Perone M J; Dunn I C; Radovick S; Brennand J; Rivier J E; Castro M G; Lovejoy D A
Direct regulation of GnRH transcription by CRF-like peptides in an immortalized neuronal cell line.
Neuroreport 1998;9(14):3135-40.
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1998: Perone M J; Windeatt S; Morrison E; Shering A; Tomasec P; Linton E; Lowenstein P R; Castro M G
Intracellular retention of the corticotrophin-releasing hormone (CRH) precursor within COS-7 cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1998;46(10):1193-7.
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1998: Perone M J; Murray C A; Brown O A; Gibson S; White A; Linton E A; Perkins A V; Lowenstein P R; Castro M G
Procorticotrophin-releasing hormone: endoproteolytic processing and differential release of its derived peptides within AtT20 cells.
Molecular and cellular endocrinology 1998;142(1-2):191-202.
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1998: Goya R G; Rowe J; Sosa Y E; Tomasec P; Lowenstein P R; Castro M G
Use of recombinant herpes simplex virus type 1 vectors for gene transfer into tumour and normal anterior pituitary cells.
Molecular and cellular endocrinology 1998;139(1-2):199-207.
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1998: Larregina A T; Morelli A E; Dewey R A; Castro M G; Fontana A; Lowenstein P R
FasL induces Fas/Apo1-mediated apoptosis in human embryonic kidney 293 cells routinely used to generate E1-deleted adenoviral vectors.
Gene therapy 1998;5(4):563-8.
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1998: Lowenstein P R; Southgate T D; Smith-Arica J R; Smith J; Castro M G
Gene therapy for inherited neurological disorders: towards therapeutic intervention in the Lesch-Nyhan syndrome.
Progress in brain research 1998;117():485-501.
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1997: Perone M J; Castro M G
Prohormone and proneuropeptide synthesis and secretion.
Histology and histopathology 1997;12(4):1179-88.
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1997: Perone M J; Windeatt S; Castro M G
Intracellular trafficking of prohormones and proneuropeptides: cell type-specific sorting and targeting.
Experimental physiology 1997;82(4):609-28.
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1997: Castro M G; Goya R G; Sosa Y E; Rowe J; Larregina A; Morelli A; Lowenstein P R
Expression of transgenes in normal and neoplastic anterior pituitary cells using recombinant adenoviruses: long term expression, cell cycle dependency, and effects on hormone secretion.
Endocrinology 1997;138(5):2184-94.
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1997: Brown O A; Santer R M; Shering A F; Larregina A T; Morelli A E; Southgate T D; Castro M G; Lowenstein P R
Gene transfer into enteric neurons of the rat small intestine in organ culture using a replication defective recombinant herpes simplex virus type 1 (HSV1) vector, but not recombinant adenovirus vectors.
Gene therapy 1997;4(4):331-8.
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1997: Shering A F; Bain D; Stewart K; Epstein A L; Castro M G; Wilkinson G W; Lowenstein P R
Cell type-specific expression in brain cell cultures from a short human cytomegalovirus major immediate early promoter depends on whether it is inserted into herpesvirus or adenovirus vectors.
The Journal of general virology 1997;78 ( Pt 2)():445-59.
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1997: Stewart K; Brown O A; Morelli A E; Fairbairn L J; Lashford L S; Cooper A; Hatton C E; Dexter T M; Castro M G; Lowenstein P R
Uptake of alpha-(L)-iduronidase produced by retrovirally transduced fibroblasts into neuronal and glial cells in vitro.
Gene therapy 1997;4(1):63-75.
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1996: Perone M J; Ahmed I; Linton E A; Castro M G
Procorticotrophin releasing hormone is endoproteolytically processed by the prohormone convertase PC2 but not by PC1 within stably transfected CHO-K1 cells.
Biochemical Society transactions 1996;24(3):497S.
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1996: Castro M G; Morrison E; Perone M J; Brown O A; Murray C A; Ahmed I; Perkins A V; Europe-Finner G; Lowenstein P R; Linton E A
Corticotrophin-releasing hormone receptor type 1: generation and characterization of polyclonal antipeptide antibodies and their localization in pituitary cells and cortical neurones in vitro.
Journal of neuroendocrinology 1996;8(7):521-31.
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1995: Castro M G; Morrison E; Tomasec P; Linton E A; Lowenstein P R
Co-localisation of autoimmune antibodies specific for double stranded DNA with procorticotrophin-releasing hormone within the nucleus of stably transfected CHO-K1 cells.
Cell and tissue research 1995;282(3):367-76.
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1995: Castro M G; Rowe J M; Murray C A; Tomasec P; Shering A F; Linton E A; Ahmed I; Lowenstein P R
Generation and characterization of an antiserum reactive with a proteolytic processing site within rat procorticotrophin-releasing hormone.
Neuropeptides 1995;29(4):183-92.
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1995: Lowenstein P R; Fournel S; Bain D; Tomasec P; Clissold P M; Castro M G; Epstein A L
Simultaneous detection of amplicon and HSV-1 helper encoded proteins reveals that neurons and astrocytoma cells do express amplicon-borne transgenes in the absence of synthesis of virus immediate early proteins.
Brain research. Molecular brain research 1995;30(1):169-75.
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1995: Morrison E; Tomasec P; Linton E A; Lowry P J; Lowenstein P R; Castro M G
Expression of biologically active procorticotrophin-releasing hormone (proCRH) in stably transfected CHO-K1 cells: characterization of nuclear proCRH.
Journal of neuroendocrinology 1995;7(4):263-72.
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1995: Lowenstein P R; Shering A F; Morrison E; Tomasec P; Bain D; Jacob T J; Wu J; Prescott A; Castro M G
Synaptogenesis and distribution of presynaptic axonal varicosities in low density primary cultures of neocortex: an immunocytochemical study utilizing synaptic vesicle-specific antibodies, and an electrophysiological examination utilizing whole cell recording.
Journal of neurocytology 1995;24(4):301-17.
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1994: Lowenstein P R; Morrison E E; Bain D; Shering A F; Banting G; Douglas P; Castro M G
Polarized distribution of the trans-Golgi network marker TGN38 during the in vitro development of neocortical neurons: effects of nocodazole and brefeldin A.
The European journal of neuroscience 1994;6(9):1453-65.
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1994: Lowenstein P R; Fournel S; Bain D; Tomasec P; Clissold P; Castro M G; Epstein A L
Herpes simplex virus 1 (HSV-1) helper co-infection affects the distribution of an amplicon encoded protein in glia.
Neuroreport 1994;5(13):1625-30.
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1994: Lowenstein P R; Morrison E E; Bain D; Hodge P; Preston C M; Clissold P; Stow N D; McKee T A; Castro M G
Use of recombinant vectors derived from herpes simplex virus 1 mutant tsK for short-term expression of transgenes encoding cytoplasmic and membrane anchored proteins in postmitotic polarized cortical neurons and glial cells in vitro.
Neuroscience 1994;60(4):1059-77.
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1994: Bain D; Wilkinson G W; Preston C M; Castro M G; Lowenstein P R
Adenovirus vectors to transfer genes into neurones: implications for gene therapy of neurological disorders.
Gene therapy 1994;1 Suppl 1():S68.
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1994: Tomasec P; Lowenstein P R; Morrison E; Hodge P; Linton E A; Perkins A; Lowry P J; Castro M G
Use of gene transfer to study post-translational modifications of neuropeptides in cell lines.
Gene therapy 1994;1 Suppl 1():S64.
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1994: Morrison E; Lowenstein P R; Hodge P; Linton E; Lowry P J; Corredoira Y; Castro M G
Nuclear and cytoplasmic localisation of procorticotrophin releasing hormone in transfected CHO-K1 cells.
Gene therapy 1994;1 Suppl 1():S62.
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1994: Lowenstein P R; Bain D; Morrison E E; Preston C M; Clissold P; Fournel S; Epstein A; Castro M G
HSV1 vectors to study protein targeting in neurones: are glycosyl-phosphatidylinositol anchors polarized targeting signals in neurones?
Gene therapy 1994;1 Suppl 1():S32-5.
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1994: Castro M G; Hodge P; Corredoira Y A; Morrison E; Tomasec P; Murray C A; Lowenstein P R
Neuropeptide gene transfer into neuronal and glial cell lines.
Gene therapy 1994;1 Suppl 1():S15-8.
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1993: Morrison E; Hodge P; Tomasec P; Lowenstein P R; Linton E A; Lowry P J; Castro M G
Nuclear localisation of corticotrophin releasing hormone (CRH) in transfected CHO-K1 cells.
Biochemical Society transactions 1993;21 ( Pt 3)(3):318S.
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1993: Goya R G; Castro M G; Linton E A; Woods R J; Sosa Y E; Lowry P J
Histones and related preparations interfere with immunoassays for peptide hormones.
Peptides 1993;14(4):777-81.
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1993: Lowenstein P R; Morrison E; Douglas P; Preston C M; Clissold P; Banting G; Stow N D; Castro M G
Neocortical neuronal polarity: targeting of a foreign protein linked to a glycosyl-phosphatidylinositol (GPI) anchor in postmitotic neurons and polarized distribution of a marker of the trans-Golgi network (TGN 38).
Biochemical Society transactions 1993;21(2):117S.
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1993: Morrison E; Lowenstein P R; Tomasec P; Hodge P; Linton E; Devine J; Lowry P J; Castro M G
Intracellular compartmentalisation of procorticotrophin releasing hormone.
Biochemical Society transactions 1993;21(1):47S.
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1993: Lowenstein P R; Morrison E; Hodge P; Tomasec P; Shering A F; Stow N D; Preston C M; James J L; Castro M G
Polarity development and synaptogenesis in low density primary cultures of neocortex. Use of herpes simplex virus-1 vectors to transfer genes into postmitotic neurons.
Biochemical Society transactions 1993;21(1):14S.
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1993: Goya R G; Castro M G; Saphier P W; Sosa Y E; Lowry P J
Thymus-pituitary interactions during ageing.
Age and ageing 1993;22(1):S19-25.
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1993: Goya R G; Castro M G; Hannah M J; Sosa Y E; Lowry P J
Thymosin peptides stimulate corticotropin release by a calcium-dependent mechanism.
Neuroendocrinology 1993;57(2):230-5.
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1993: Goya R G; Castro M G; Hannah M J; Sosa Y E; Lowry P J
Corticotropin-releasing (CRH) activity of thymic peptides on CRH-insensitive corticotropic tumor cells.
Medicina 1993;53(2):108-12.
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1992: Castro M G; Lowry P J; Lowenstein P R
Antibodies to neuropeptide precursors expressed as fusion proteins in E. coli. Their use to examine neuropeptide biosynthetic pathways, intracellular trafficking and physiological activities.
The International journal of biochemistry 1992;24(6):847-60.
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1991: Castro M G; Brooke J; Bullman A; Hannah M; Glynn B P; Lowry P J
Biosynthesis of corticotrophin-releasing hormone (CRH) in mouse corticotrophic tumour cells expressing the human proCRH gene: intracellular storage and regulated secretion.
Journal of molecular endocrinology 1991;7(2):97-104.
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1991: Gilbert M S; Lowry P J; Castro M G; Woods R J; Savva D
Expression and partial purification of human prolactin in Escherichia coli.
The International journal of biochemistry 1991;23(1):107-14.
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1990: Castro M G; Lowenstein P R; Saphier P W; Linton E A; Lowry P J
The use of inclusion bodies, isolated from Escherichia coli expressing corticotrophin-releasing hormone precursor, to raise specific antibodies against the neuropeptide moiety.
Journal of molecular endocrinology 1990;5(3):221-30.
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1990: Castro M G; Bullman A P; Brooke J E; Lowry P J
Production and release of corticotropin releasing hormone (CRH) from AtT-20 cells stably transfected with the human CRH gene.
Biochemical Society transactions 1990;18(6):1250-1.
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1990: Castro M G; Spruce B A; Savva D; Lowry P J
Expression of biologically active human pre-procorticotropin releasing hormone in E. coli: characterization and purification.
The International journal of biochemistry 1990;22(11):1341-9.
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