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Maria Castro

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Mariana Puntel; Alireza Salem; Nathan Vanderveen; Ghulam Muhammad A K M; Ashley Appelhans; Catherine Farrokhi; Sukhpreet Kaur; Kyle R Kelson; Sean Kennedy; Johnny Krasinkiewicz; Kurt M Kroeger; Liliana Lacayo; Chunyan Liu; Pedro R Lowenstein; Philip Ng; Donna Palmer; Christopher Paran; Robert N Pechnick; Maria G Castro
Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma.
Hikmat Assi; Gregory Baker; Marianela Candolfi; Pedro R Lowenstein; Yohei Mineharu; Maria G Castro
Gene therapy for brain tumors: basic developments and clinical implementation.
Yohei Mineharu; Mariana Puntel; Weidong Xiong; Kader Yagiz; A K M Ghulam Muhammad; Michael A Curran; Adrina Kocharian; Kurt M Kroeger; Eva Levy; Chunyan Liu; Pedro R Lowenstein; Claudia Lugo; James P Allison; Marianela Candolfi; Maria G Castro
Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-κB signaling improves the efficacy of immunotherapy in a brain cancer model.

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2013: Mariana Puntel; Alireza Salem; Nathan Vanderveen; Ghulam Muhammad A K M; Ashley Appelhans; Catherine Farrokhi; Sukhpreet Kaur; Kyle R Kelson; Sean Kennedy; Johnny Krasinkiewicz; Kurt M Kroeger; Liliana Lacayo; Chunyan Liu; Pedro R Lowenstein; Philip Ng; Donna Palmer; Christopher Paran; Robert N Pechnick; Maria G Castro
Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma.
Toxicology and applied pharmacology 2013;268(3):318-30.
2012: Hikmat Assi; Gregory Baker; Marianela Candolfi; Pedro R Lowenstein; Yohei Mineharu; Maria G Castro
Gene therapy for brain tumors: basic developments and clinical implementation.
Neuroscience letters 2012;527(2):71-7.
2012: Yohei Mineharu; Mariana Puntel; Weidong Xiong; Kader Yagiz; A K M Ghulam Muhammad; Michael A Curran; Adrina Kocharian; Kurt M Kroeger; Eva Levy; Chunyan Liu; Pedro R Lowenstein; Claudia Lugo; James P Allison; Marianela Candolfi; Maria G Castro
Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-κB signaling improves the efficacy of immunotherapy in a brain cancer model.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2012;9(4):827-43.
2012: Marianela Candolfi; Nick Barnett; James F Curtin; David Foulad; Régis Josien; Gwendalyn D King; Kurt M Kroeger; Pedro R Lowenstein; Yohei Mineharu; Kader Yagiz; A K M Ghulam Muhammad; Maria G Castro
Plasmacytoid dendritic cells in the tumor microenvironment: immune targets for glioma therapeutics.
Neoplasia (New York, N.Y.) 2012;14(8):757-70.
2012: A K M Ghulam Muhammad; Catherine Farrokhi; Kyle R Kelson; Kurt M Kroeger; Liliana Lacayo; Chunyan Liu; Pedro R Lowenstein; Philip Ng; Donna Palmer; Robert N Pechnick; Mariana Puntel; Alireza Salem; Weidong Xiong; Maria G Castro
Safety profile of gutless adenovirus vectors delivered into the normal brain parenchyma: implications for a glioma phase 1 clinical trial.
Human gene therapy methods 2012;23(4):271-84.
2012: Pedro R Lowenstein; Maria G Castro
Pushing the limits of glioma resection using electrophysiologic brain mapping.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(20):2437-40.
2012: Nicholas Stephen Rennie Sanderson; Mark Swerdlow; Hideo Yagita; Mariana Puntel; Niyati S Bondale; Maria G Castro; Ahmed Ibrahim; Niloufar Iranmanesh; Kurt M Kroeger; Pedro R Lowenstein
Cytotoxic immunological synapses do not restrict the action of interferon-γ to antigenic target cells.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(20):7835-40.
2012: Jeffrey M Zirger; Rameen Moridzadeh; Mariana Puntel; Mia Wibowo; Carlos Barcia; Josee Bergeron; Niyati Bondale; Maria G Castro; Kurt M Kroeger; Chunyan Liu; Pedro R Lowenstein
Immune-mediated loss of transgene expression from virally transduced brain cells is irreversible, mediated by IFNγ, perforin, and TNFα, and due to the elimination of transduced cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(4):808-19.
2011: Marianela Candolfi; Gabrielle E Alzadeh; Hikmat Assi; James F Curtin; Robert Dunn; David Foulad; Naomi Keech; Kurt M Kroeger; Chunyan Liu; Pedro R Lowenstein; Gislaine Martins; Mariana Puntel; Sofia Salehi; Nicholas R Sanderson; Mia K Wibowo; Kader Yagiz; A K M G Muhammad; Maria G Castro
B cells are critical to T-cell-mediated antitumor immunity induced by a combined immune-stimulatory/conditionally cytotoxic therapy for glioblastoma.
Neoplasia (New York, N.Y.) 2011;13(10):947-60.
2011: Marianela Candolfi; Hikmat Assi; Gregory J Baker; David Foulad; Kurt M Kroeger; Chunyan Liu; Pedro R Lowenstein; Yohei Mineharu; Akm Ghulam Muhammad; Mariana Puntel; Mia Wibowo; Weidong Xiong; Kader Yagiz; Maria G Castro
Targeted toxins for glioblastoma multiforme: pre-clinical studies and clinical implementation.
Anti-cancer agents in medicinal chemistry 2011;11(8):729-38.
2011: Gwendalyn D King; Kurt M Kroeger; Daniel Larocque; Chunyan Liu; Maria G Castro; Kyle R Kelson; A K M Ghulam Muhammad; Nicholas S R Sanderson; Weidong Xiong; Pedro R Lowenstein
Combined Flt3L/TK gene therapy induces immunological surveillance which mediates an immune response against a surrogate brain tumor neoantigen.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(10):1793-801.
2011: Yohei Mineharu; A K M G Muhammad; Serguei Bannykh; Gwendalyn D King; Kurt M Kroeger; Chunyan Liu; Pedro R Lowenstein; Maria G Castro
Engineering the brain tumor microenvironment enhances the efficacy of dendritic cell vaccination: implications for clinical trial design.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(14):4705-18.
2011: Maria G Castro; Marianela Candolfi; Kurt M Kroeger; Gwendalyn D King; James F Curtin; Kader Yagiz; Yohei Mineharu; Hikmat Assi; Mia Wibowo; A K M Ghulam Muhammad; David Foulad; Mariana Puntel; Pedro R Lowenstein
Gene therapy and targeted toxins for glioma.
Current gene therapy 2011;11(3):155-80.
2011: Mariana Puntel; Nicholas S R Sanderson; Mia Wibowo; Robert Barrett; Niyati Bondale; Maria G Castro; Sean Kennedy; Kurt M Kroeger; Chunyan Liu; Pedro R Lowenstein
Identification and visualization of CD8+ T cell mediated IFN-γ signaling in target cells during an antiviral immune response in the brain.
PloS one 2011;6(8):e23523.
2010: Marianela Candolfi; Weidong Xiong; Kader Yagiz; Chunyan Liu; A K M G Muhammad; Mariana Puntel; David Foulad; Ali Zadmehr; Gabrielle E Ahlzadeh; Kurt M Kroeger; Matthew Tesarfreund; Sharon Lee; Waldemar Debinski; Dhruv Sareen; Clive Svendsen; Ronald Rodriguez; Pedro R Lowenstein; Maria G Castro
Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(46):20021-6.
2010: Kurt M Kroeger; A K M Ghulam Muhammad; Gregory J Baker; Hikmat Assi; Mia K Wibowo; Weidong Xiong; Kader Yagiz; Marianela Candolfi; Pedro R Lowenstein; Maria G Castro
Gene therapy and virotherapy: novel therapeutic approaches for brain tumors.
Discovery medicine 2010;10(53):293-304.
2010: Daniel Larocque; Nicholas S R Sanderson; Josée Bergeron; James F Curtin; Joe Girton; Mia Wibowo; Niyati Bondale; Kurt M Kroeger; Jieping Yang; Liliana M Lacayo; Kevin C Reyes; Catherine Farrokhi; Robert N Pechnick; Maria G Castro; Pedro R Lowenstein
Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune privilege and facilitates recognition of a neo-antigen without causing autoimmune neuropathology.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(32):14443-8.
2010: A K M G Muhammad; Mariana Puntel; Marianela Candolfi; A Salem; K Yagiz; C Farrokhi; Kurt M Kroeger; Weidong Xiong; James F Curtin; Chunyan Liu; K Lawrence; N S Bondale; J Lerner; G J Baker; D Foulad; Robert N Pechnick; Donna Palmer; P Ng; Pedro R Lowenstein; Maria G Castro
Study of the efficacy, biodistribution, and safety profile of therapeutic gutless adenovirus vectors as a prelude to a phase I clinical trial for glioblastoma.
Clinical pharmacology and therapeutics 2010;88(2):204-13.
2010: Mariana Puntel; A K M G Muhammad; Marianela Candolfi; Alireza Salem; Kader Yagiz; Catherine Farrokhi; Kurt M Kroeger; Weidong Xiong; James F Curtin; Chunyan Liu; Niyati S Bondale; Jonathan Lerner; Robert N Pechnick; Donna Palmer; Philip Ng; Pedro R Lowenstein; Maria G Castro
A novel bicistronic high-capacity gutless adenovirus vector that drives constitutive expression of herpes simplex virus type 1 thymidine kinase and tet-inducible expression of Flt3L for glioma therapeutics.
Journal of virology 2010;84(12):6007-17.
2010: G Elizabeth Pluhar; Patrick T Grogan; Charlie Seiler; Michelle Goulart; Karen S Santacruz; Cathy Carlson; Wei Chen; Mike R Olin; Pedro R Lowenstein; Maria G Castro; Stephen J Haines; John R Ohlfest
Anti-tumor immune response correlates with neurological symptoms in a dog with spontaneous astrocytoma treated by gene and vaccine therapy.
Vaccine 2010;28(19):3371-8.
2010: J Yang; N S R Sanderson; K Wawrowsky; Mariana Puntel; Maria G Castro; Pedro R Lowenstein
Kupfer-type immunological synapse characteristics do not predict anti-brain tumor cytolytic T-cell function in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(10):4716-21.
2010: Mehrnoosh Saghizadeh; Andrei A Kramerov; Yousha Yaghoobzadeh; Jinwei Hu; Julia Y Ljubimova; Keith L Black; Maria G Castro; Alexander V Ljubimov
Adenovirus-driven overexpression of proteinases in organ-cultured normal human corneas leads to diabetic-like changes.
Brain research bulletin 2010;81(2-3):262-72.
2010: Weidong Xiong; Marianela Candolfi; Chunyan Liu; A K M Ghulam Muhammad; Kader Yagiz; Mariana Puntel; Peter F Moore; Julie Avalos; John D Young; Dorothy Khan; Randy Donelson; G Elizabeth Pluhar; John R Ohlfest; Kolja Wawrowsky; Pedro R Lowenstein; Maria G Castro
Human Flt3L generates dendritic cells from canine peripheral blood precursors: implications for a dog glioma clinical trial.
PloS one 2010;5(6):e11074.
2010: Mariana Puntel; Kurt M Kroeger; Nicholas S R Sanderson; Clare E Thomas; Maria G Castro; Pedro R Lowenstein
Gene transfer into rat brain using adenoviral vectors.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2010;Chapter 4():Unit 4.24.
2009: Marianela Candolfi; Kurt M Kroeger; A K M G Muhammad; Kader Yagiz; Catherine Farrokhi; Robert N Pechnick; Pedro R Lowenstein; Maria G Castro
Gene therapy for brain cancer: combination therapies provide enhanced efficacy and safety.
Current gene therapy 2009;9(5):409-21.
2009: Pedro R Lowenstein; Maria G Castro
Uncertainty in the translation of preclinical experiments to clinical trials. Why do most phase III clinical trials fail?
Current gene therapy 2009;9(5):368-74.
2009: Maria G Castro; Pedro R Lowenstein
Gene therapy continues to make progress: clinical and regulatory perspectives.
Current gene therapy 2009;9(5):327-8.
2009: Pedro R Lowenstein; Elijah D Lowenstein; Maria G Castro
Challenges in the evaluation, consent, ethics and history of early clinical trials - Implications of the Tuskegee 'trial' for safer and more ethical clinical trials.
Current opinion in molecular therapeutics 2009;11(5):481-4.
2009: A K M Ghulam Muhammad; Marianela Candolfi; Gwendalyn D King; Kader Yagiz; David Foulad; Yohei Mineharu; Kurt M Kroeger; Katherine A Treuer; W Stephen Nichols; Nicholas S Sanderson; Jieping Yang; Maksim Khayznikov; Nico van Rooijen; Pedro R Lowenstein; Maria G Castro
Antiglioma immunological memory in response to conditional cytotoxic/immune-stimulatory gene therapy: humoral and cellular immunity lead to tumor regression.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(19):6113-27.
2009: Marianela Candolfi; Kader Yagiz; David Foulad; Gabrielle E Alzadeh; Matthew Tesarfreund; A K M Ghulam Muhammad; Mariana Puntel; Kurt M Kroeger; Chunyan Liu; Sharon Lee; James F Curtin; Gwendalyn D King; Jonathan Lerner; Katsuaki Sato; Yohei Mineharu; Weidong Xiong; Pedro R Lowenstein; Maria G Castro
Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(13):4401-14.
2009: Mariana Puntel; R J Barrett; Sonali Mondkar; V Saxena; Kurt M Kroeger; A K M Muhammad; Chunyan Liu; N Bondale; Sandra A Sciascia; Weidong Xiong; Y Shi; A Salem; A Zadmehr; P Huynh; Donna Palmer; P Ng; Maria G Castro; Pedro R Lowenstein
Herpes simplex virus type 1 thymidine kinase sequence fused to the lacz gene increases levels of {beta}-galactosidase activity per genome of high-capacity but not first-generation adenoviral vectors in vitro and in vivo.
Journal of virology 2009;83(4):2004-10.
2009: James F Curtin; Naiyou Liu; Marianela Candolfi; Weidong Xiong; Hikmat Assi; Kader Yagiz; Matthew R Edwards; Kathrin S Michelsen; Kurt M Kroeger; Chunyan Liu; A K M Ghulam Muhammad; Mary C Clark; Moshe Arditi; Begonya Comin-Anduix; Antoni Ribas; Pedro R Lowenstein; Maria G Castro
HMGB1 mediates endogenous TLR2 activation and brain tumor regression.
PLoS medicine 2009;6(1):e10.
2008: Thomas Southgate; Kurt M Kroeger; Chunyan Liu; Pedro R Lowenstein; Maria G Castro
Gene transfer into neural cells in vitro using adenoviral vectors.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2008;Chapter 4():Unit 4.23.
2008: Gwendalyn D King; A K M Ghulam Muhammad; Weidong Xiong; Kurt M Kroeger; Mariana Puntel; Daniel Larocque; Donna Palmer; Philip Ng; Pedro R Lowenstein; Maria G Castro
High-capacity adenovirus vector-mediated anti-glioma gene therapy in the presence of systemic antiadenovirus immunity.
Journal of virology 2008;82(9):4680-4.
2008: Gwendalyn D King; Kurt M Kroeger; Catherine J Bresee; Marianela Candolfi; Chunyan Liu; Charlene M Manalo; A K M Ghulam Muhammad; Robert N Pechnick; Pedro R Lowenstein; Maria G Castro
Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain tumor-induced behavioral deficits.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(4):682-90.
2008: Carlos Barcia; Kolja Wawrowsky; Robert J Barrett; Chunyan Liu; Maria G Castro; Pedro R Lowenstein
In vivo polarization of IFN-gamma at Kupfer and non-Kupfer immunological synapses during the clearance of virally infected brain cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(3):1344-52.
2008: Weidong Xiong; Marianela Candolfi; Kurt M Kroeger; Mariana Puntel; Sonali Mondkar; Daniel Larocque; Chunyan Liu; James F Curtin; Donna Palmer; Philip Ng; Pedro R Lowenstein; Maria G Castro
Immunization against the transgene but not the TetON switch reduces expression from gutless adenoviral vectors in the brain.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(2):343-51.
2008: Gwendalyn D King; A K M Ghulam Muhammad; James F Curtin; Carlos Barcia; Mariana Puntel; Chunyan Liu; Sarah B Honig; Marianela Candolfi; Sonali Mondkar; Pedro R Lowenstein; Maria G Castro
Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model.
Neuro-oncology 2008;10(1):19-31.
2008: Carlos Barcia; Nicholas S R Sanderson; Robert J Barrett; Kolja Wawrowsky; Kurt M Kroeger; Mariana Puntel; Chunyan Liu; Maria G Castro; Pedro R Lowenstein
T cells' immunological synapses induce polarization of brain astrocytes in vivo and in vitro: a novel astrocyte response mechanism to cellular injury.
PloS one 2008;3(8):e2977.
2008: James F Curtin; Marianela Candolfi; Tamer M Fakhouri; Chunyan Liu; Anderson Alden; Matthew Edwards; Pedro R Lowenstein; Maria G Castro
Treg depletion inhibits efficacy of cancer immunotherapy: implications for clinical trials.
PloS one 2008;3(4):e1983.
2007: Carlos Barcia; Maximiliano Jimenez-Dalmaroni; Kurt M Kroeger; Mariana Puntel; Alison J Rapaport; Daniel Larocque; Gwendalyn D King; Stephen A Johnson; Chunyan Liu; Weidong Xiong; Marianela Candolfi; Sonali Mondkar; Philip Ng; Donna Palmer; Maria G Castro; Pedro R Lowenstein
One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(12):2154-63.
2007: Marianela Candolfi; James F Curtin; W Stephen Nichols; Akm G Muhammad; Gwendalyn D King; G Elizabeth Pluhar; Elizabeth A McNiel; John R Ohlfest; Andrew Freese; Peter F Moore; Jonathan Lerner; Pedro R Lowenstein; Maria G Castro
Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression.
Journal of neuro-oncology 2007;85(2):133-48.
2007: Pedro R Lowenstein; Ronald J Mandel; Wei-Dong Xiong; Kurt M Kroeger; Maria G Castro
Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions.
Current gene therapy 2007;7(5):347-60.
2007: Pedro R Lowenstein; Kurt M Kroeger; Maria G Castro
Immunology of neurological gene therapy: how T cells modulate viral vector-mediated therapeutic transgene expression through immunological synapses.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2007;4(4):715-24.
2007: Seunguk Oh; Rick Odland; Scott R Wilson; Kurt M Kroeger; Chunyan Liu; Pedro R Lowenstein; Maria G Castro; Walter A Hall; John R Ohlfest
Improved distribution of small molecules and viral vectors in the murine brain using a hollow fiber catheter.
Journal of neurosurgery 2007;107(3):568-77.
2007: Seunguk Oh; G Elizabeth Pluhar; Elizabeth A McNeil; Kurt M Kroeger; Chunyan Liu; Maria G Castro; Pedro R Lowenstein; Andrew Freese; John R Ohlfest
Efficacy of nonviral gene transfer in the canine brain.
Journal of neurosurgery 2007;107(1):136-44.
2007: Marianela Candolfi; G Elizabeth Pluhar; Kurt M Kroeger; Mariana Puntel; James Curtin; Carlos Barcia; A K M Ghulam Muhammad; Weidong Xiong; Chunyan Liu; Sonali Mondkar; William Kuoy; Terry Kang; Elizabeth A McNeil; Andrew Freese; John R Ohlfest; Peter F Moore; Donna Palmer; Phillip Ng; John D Young; Pedro R Lowenstein; Maria G Castro
Optimization of adenoviral vector-mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro.
Neuro-oncology 2007;9(3):245-58.
2007: Marianela Candolfi; Kurt M Kroeger; G Elizabeth Pluhar; Josee Bergeron; Mariana Puntel; James F Curtin; Elizabeth A McNiel; Andrew Freese; John R Ohlfest; Peter F Moore; Pedro R Lowenstein; Maria G Castro
Adenoviral-mediated gene transfer into the canine brain in vivo.
Neurosurgery 2007;60(1):167-77; discussion 178.
2006: Carlos Barcia; Christian Gerdes; Wei-Dong Xiong; Clare E Thomas; Chunyan Liu; Kurt M Kroeger; Maria G Castro; Pedro R Lowenstein
Immunological thresholds in neurological gene therapy: highly efficient elimination of transduced cells might be related to the specific formation of immunological synapses between T cells and virus-infected brain cells.
Neuron glia biology 2006;2(4):309-22.
2006: Carlos Barcia; Clare E Thomas; James F Curtin; Gwendalyn D King; Kolja Wawrowsky; Marianela Candolfi; Wei-Dong Xiong; Chunyan Liu; Kurt M Kroeger; Olivier Boyer; Jerzy W Kupiec-Weglinski; David Klatzmann; Maria G Castro; Pedro R Lowenstein
In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain.
The Journal of experimental medicine 2006;203(9):2095-107.
2006: Marianela Candolfi; James F Curtin; Wei-Dong Xiong; Kurt M Kroeger; Chunyan Liu; Altan Rentsendorj; Hasmik Agadjanian; Lali K Medina-Kauwe; Donna Palmer; Philip Ng; Pedro R Lowenstein; Maria G Castro
Effective high-capacity gutless adenoviral vectors mediate transgene expression in human glioma cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(3):371-81.
2006: Marianela Candolfi; Gabriela Jaita; Daniel Pisera; L Ferrari; Carlos Barcia; C Liu; J Yu; G Liu; Maria G Castro; Adriana Seilicovich
Adenoviral vectors encoding tumor necrosis factor-alpha and FasL induce apoptosis of normal and tumoral anterior pituitary cells.
The Journal of endocrinology 2006;189(3):681-90.
2006: Mariana Puntel; James F Curtin; Jeffrey M Zirger; A K M Muhammad; Weidong Xiong; Chunyan Liu; Jinwei Hu; Kurt M Kroeger; P Czer; Sandra A Sciascia; Sonali Mondkar; Pedro R Lowenstein; Maria G Castro
Quantification of high-capacity helper-dependent adenoviral vector genomes in vitro and in vivo, using quantitative TaqMan real-time polymerase chain reaction.
Human gene therapy 2006;17(5):531-44.
2006: James F Curtin; Gwendalyn D King; Carlos Barcia; Chunyan Liu; FX Hubert; Carole Guillonneau; Régis Josien; Ignacio Anegon; Pedro R Lowenstein; Maria G Castro
Fms-like tyrosine kinase 3 ligand recruits plasmacytoid dendritic cells to the brain.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(6):3566-77.
2006: Jeffrey M Zirger; Chunyan Liu; Carlos Barcia; Maria G Castro; Pedro R Lowenstein
Immune regulation of transgene expression in the brain: B cells regulate an early phase of elimination of transgene expression from adenoviral vectors.
Viral immunology 2006;19(3):508-17.
2006: Weidong Xiong; Shyam Goverdhana; Sandra A Sciascia; Marianela Candolfi; Jeffrey M Zirger; Carlos Barcia; James F Curtin; Gwendalyn D King; Gabriela Jaita; Chunyan Liu; Kurt M Kroeger; Hasmik Agadjanian; Lali K Medina-Kauwe; Donna Palmer; Philip Ng; Pedro R Lowenstein; Maria G Castro
Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses.
Journal of virology 2006;80(1):27-37.
2005: Adriana Seilicovich; Daniel Pisera; Sandra A Sciascia; Marianela Candolfi; Mariana Puntel; Weidong Xiong; Gabriela Jaita; Maria G Castro
Gene therapy for pituitary tumors.
Current gene therapy 2005;5(6):559-72.
2005: Gwendalyn D King; James F Curtin; Marianela Candolfi; Kurt M Kroeger; Pedro R Lowenstein; Maria G Castro
Gene therapy and targeted toxins for glioma.
Current gene therapy 2005;5(6):535-57.
2005: Gabriela Jaita; Marianela Candolfi; Verónica Zaldivar; Sandra Zárate; L Ferrari; Daniel Pisera; Maria G Castro; Adriana Seilicovich
Estrogens up-regulate the Fas/FasL apoptotic pathway in lactotropes.
Endocrinology 2005;146(11):4737-44.
2005: Sumia Ali; Gwendalyn D King; James F Curtin; Marianela Candolfi; Weidong Xiong; Chunyan Liu; Mariana Puntel; Queng Cheng; Jesus Prieto; Antoni Ribas; Jerzy W Kupiec-Weglinski; Nico van Rooijen; Hans Lassmann; Pedro R Lowenstein; Maria G Castro
Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.
Cancer research 2005;65(16):7194-204.
2005: Shyam Goverdhana; Mariana Puntel; Weidong Xiong; Jeffrey M Zirger; Carlos Barcia; James F Curtin; E B Soffer; Sonali Mondkar; Gwendalyn D King; Jinwei Hu; Sandra A Sciascia; Marianela Candolfi; D S Greengold; Pedro R Lowenstein; Maria G Castro
Regulatable gene expression systems for gene therapy applications: progress and future challenges.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(2):189-211.
2005: Evelyn Abordo-Adesida; Antonia Follenzi; Carlos Barcia; Sandra A Sciascia; Maria G Castro; Luigi Naldini; Pedro R Lowenstein
Stability of lentiviral vector-mediated transgene expression in the brain in the presence of systemic antivector immune responses.
Human gene therapy 2005;16(6):741-51.
2005: Marianela Candolfi; Gabriela Jaita; Verónica Zaldivar; Sandra Zárate; L Ferrari; Daniel Pisera; Maria G Castro; Adriana Seilicovich
Progesterone antagonizes the permissive action of estradiol on tumor necrosis factor-alpha-induced apoptosis of anterior pituitary cells.
Endocrinology 2005;146(2):736-43.
2005: James F Curtin; Gwendalyn D King; Marianela Candolfi; Remy B Greeno; Kurt M Kroeger; Pedro R Lowenstein; Maria G Castro
Combining cytotoxic and immune-mediated gene therapy to treat brain tumors.
Current topics in medicinal chemistry 2005;5(12):1151-70.
2004: Donata Suwelack; Andres Hurtado-Lorenzo; E Millan; V Gonzalez-Nicolini; Kolja Wawrowsky; Pedro R Lowenstein; Maria G Castro
Neuronal expression of the transcription factor Gli1 using the Talpha1 alpha-tubulin promoter is neuroprotective in an experimental model of Parkinson's disease.
Gene therapy 2004;11(24):1742-52.
2004: Sumia Ali; James F Curtin; Jeffrey M Zirger; Weidong Xiong; Gwendalyn D King; Carlos Barcia; Chunyan Liu; Mariana Puntel; Shyam Goverdhana; Pedro R Lowenstein; Maria G Castro
Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L): treatment with hsFlt3L inhibits intracranial glioma progression.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(6):1071-84.
2004: Alireza Biglari; Dominique Bataille; Ulrike Naumann; Michael Weller; Jeffrey M Zirger; Maria G Castro; Pedro R Lowenstein
Effects of ectopic decorin in modulating intracranial glioma progression in vivo, in a rat syngeneic model.
Cancer gene therapy 2004;11(11):721-32.
2004: Daniel Pisera; Marianela Candolfi; S Navarra; J Ferraris; Verónica Zaldivar; Gabriela Jaita; Maria G Castro; Adriana Seilicovich
Estrogens sensitize anterior pituitary gland to apoptosis.
American journal of physiology. Endocrinology and metabolism 2004;287(4):E767-71.
2004: Andres Hurtado-Lorenzo; E Millan; V Gonzalez-Nicolini; Donata Suwelack; Maria G Castro; Pedro R Lowenstein
Differentiation and transcription factor gene therapy in experimental parkinson's disease: sonic hedgehog and Gli-1, but not Nurr-1, protect nigrostriatal cell bodies from 6-OHDA-induced neurodegeneration.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(3):507-24.
2004: Bibo Ke; Xiu-Da Shen; Feng Gao; Ronald W Busuttil; Pedro R Löwenstein; Maria G Castro; Jerzy W Kupiec-Weglinski
Gene therapy for liver transplantation using adenoviral vectors: CD40-CD154 blockade by gene transfer of CD40Ig protects rat livers from cold ischemia and reperfusion injury.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(1):38-45.
2003: Paul Andrew Kingston; Sanjay Sinha; Clare E Appleby; Anne David; Thomas Verakis; Maria G Castro; Pedro R Lowenstein; Anthony M Heagerty
Adenovirus-mediated gene transfer of transforming growth factor-beta3, but not transforming growth factor-beta1, inhibits constrictive remodeling and reduces luminal loss after coronary angioplasty.
Circulation 2003;108(22):2819-25.
2003: Daniel Stone; Weidong Xiong; Judith C Williams; Anne David; Pedro R Lowenstein; Maria G Castro
Adenovirus expression of IL-1 and NF-kappaB inhibitors does not inhibit acute adenoviral-induced brain inflammation, but delays immune system-mediated elimination of transgene expression.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(3):400-11.
2003: Clare E Appleby; Paul Andrew Kingston; Anne David; Christian A Gerdes; P Umaña; Maria G Castro; Pedro R Lowenstein; Anthony M Heagerty
A novel combination of promoter and enhancers increases transgene expression in vascular smooth muscle cells in vitro and coronary arteries in vivo after adenovirus-mediated gene transfer.
Gene therapy 2003;10(18):1616-22.
2003: J Anne Stirland; ZC Seymour; S Windeatt; AJ Norris; P Stanley; Maria G Castro; Andrew S I Loudon; Michael R H White; Julian R E Davis
Real-time imaging of gene promoter activity using an adenoviral reporter construct demonstrates transcriptional dynamics in normal anterior pituitary cells.
The Journal of endocrinology 2003;178(1):61-9.
2003: Pedro R Lowenstein; Maria G Castro
Inflammation and adaptive immune responses to adenoviral vectors injected into the brain: peculiarities, mechanisms, and consequences.
Gene therapy 2003;10(11):946-54.
2003: Cécile Guillot; Séverine Ménoret; Carole Guillonneau; Cécile Braudeau; Maria G Castro; Pedro R Lowenstein; Ignacio Anegon
Active suppression of allogeneic proliferative responses by dendritic cells after induction of long-term allograft survival by CTLA4Ig.
Blood 2003;101(8):3325-33.
2003: Maria G Castro; Rachel L Cowen; I K Williamson; A David; M J Jimenez-Dalmaroni; X Yuan; A Bigliari; J C Williams; J Hu; Pedro R Lowenstein
Current and future strategies for the treatment of malignant brain tumors.
Pharmacology & therapeutics 2003;98(1):71-108.
2003: Pedro R Lowenstein; Donata Suwelack; Jinwei Hu; Xianpeng Yuan; Maximiliano Jimenez-Dalmaroni; Shyam Goverdhana; Maria G Castro
Nonneurotropic adenovirus: a vector for gene transfer to the brain and gene therapy of neurological disorders.
International review of neurobiology 2003;55():3-64.
2003: Andres Hurtado-Lorenzo; Anne David; Clare Thomas; Maria G Castro; Pedro R Lowenstein
Use of recombinant adenovirus for gene transfer into the rat brain. Evaluation of gene transfer efficiency, toxicity, and inflammatory and immune reactions.
Methods in molecular medicine 2003;76():113-33.
2002: Rachel L Cowen; Judith C Williams; Steve Emery; David Blakey; John L Darling; Pedro R Lowenstein; Maria G Castro
Adenovirus vector-mediated delivery of the prodrug-converting enzyme carboxypeptidase G2 in a secreted or GPI-anchored form: High-level expression of this active conditional cytotoxic enzyme at the plasma membrane.
Cancer gene therapy 2002;9(11):897-907.
2002: Ana Grande-Pérez; Saleta Sierra; Maria G Castro; Esteban Domingo; Pedro R Lowenstein
Molecular indetermination in the transition to error catastrophe: systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):12938-43.
2002: Julian R E Davis; Raymond F T McMahon; Pedro R Lowenstein; Maria G Castro; Gerald A Lincoln; Alan S McNeilly
Adenovirus-mediated gene transfer in the ovine pituitary gland is associated with hypophysitis.
The Journal of endocrinology 2002;173(2):265-71.
2002: Clare E Thomas; Penny Edwards; Thomas J Wickham; Maria G Castro; Pedro R Lowenstein
Adenovirus binding to the coxsackievirus and adenovirus receptor or integrins is not required to elicit brain inflammation but is necessary to transduce specific neural cell types.
Journal of virology 2002;76(7):3452-60.
2002: Cécile Guillot; Carole Guillonneau; Patrick Mathieu; Christian A Gerdes; Séverine Ménoret; Cécile Braudeau; Laurent Tesson; Karine Renaudin; Maria G Castro; Pedro R Löwenstein; Ignacio Anegon
Prolonged blockade of CD40-CD40 ligand interactions by gene transfer of CD40Ig results in long-term heart allograft survival and donor-specific hyporesponsiveness, but does not prevent chronic rejection.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1600-9.
2002: YN Mohammad; Marcelo J Perone; L Wang; P M Ingleton; Maria G Castro; DA Lovejoy
Expression of prolactin receptors and regulation of cell proliferation by prolactin, corticotropin-releasing factor, and corticosterone in a neuroblastoma cell line.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2002;80(4):475-82.
2002: Pedro R Lowenstein; C E Thomas; P Umana; Christian A Gerdes; Thomas Verakis; O Boyer; S Tondeur; D Klatzmann; Maria G Castro
High-capacity, helper-dependent, "gutless" adenoviral vectors for gene transfer into brain.
Methods in enzymology 2002;346():292-311.
2001: Judith C Williams; D Stone; JR Smith-Arica; Ian morris; Pedro R Lowenstein; Maria G Castro
Regulated, adenovirus-mediated delivery of tyrosine hydroxylase suppresses growth of estrogen-induced pituitary prolactinomas.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;4(6):593-602.
2001: Paul Andrew Kingston; S Sinha; Anne David; Maria G Castro; Pedro R Lowenstein; Anthony M Heagerty
Adenovirus-mediated gene transfer of a secreted transforming growth factor-beta type II receptor inhibits luminal loss and constrictive remodeling after coronary angioplasty and enhances adventitial collagen deposition.
Circulation 2001;104(21):2595-601.
2001: A J Zermansky; F Bolognani; D Stone; CM Cowsill; Graham Morrissey; Maria G Castro; Pedro R Löwenstein
Towards global and long-term neurological gene therapy: unexpected transgene dependent, high-level, and widespread distribution of HSV-1 thymidine kinase throughout the CNS.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;4(5):490-8.
2001: Maria G Castro; Anne David; Andres Hurtado-Lorenzo; Donata Suwelack; E Millan; Thomas Verakis; Wei-Dong Xiong; X P Yuan; Pedro R Lowenstein
Gene therapy for Parkinson's disease: recent achievements and remaining challenges.
Histology and histopathology 2001;16(4):1225-38.
2001: TC Maleniak; J L Darling; Pedro R Lowenstein; Maria G Castro
Adenovirus-mediated expression of HSV1-TK or Fas ligand induces cell death in primary human glioma-derived cell cultures that are resistant to the chemotherapeutic agent CCNU.
Cancer gene therapy 2001;8(8):589-98.
2001: P Umaña; Christian A Gerdes; D Stone; Julian R E Davis; D Ward; Maria G Castro; Pedro R Lowenstein
Efficient FLPe recombinase enables scalable production of helper-dependent adenoviral vectors with negligible helper-virus contamination.
Nature biotechnology 2001;19(6):582-5.
2001: JR Smith-Arica; Judith C Williams; D Stone; J Smith; Pedro R Lowenstein; Maria G Castro
Switching on and off transgene expression within lactotrophic cells in the anterior pituitary gland in vivo.
Endocrinology 2001;142(6):2521-32.
2001: Thomas D Southgate; Paul Andrew Kingston; Maria G Castro
Gene transfer into neural cells in vitro using adenoviral vectors.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2001;Chapter 4():Unit 4.23.
2001: Clare E Thomas; Gudrun Schiedner; Stefan Kochanek; Maria G Castro; Pedro R Lowenstein
Preexisting antiadenoviral immunity is not a barrier to efficient and stable transduction of the brain, mediated by novel high-capacity adenovirus vectors.
Human gene therapy 2001;12(7):839-46.
2001: Maria G Castro; Thomas D Southgate; Pedro R Lowenstein
Molecular therapy in a model neuroendocrine disease: developing clinical gene therapy for pituitary tumours.
Trends in endocrinology and metabolism: TEM 2001;12(2):58-64.
2001: J Anne Stirland; Jonathan D Johnston; Felino R A Cagampang; P J Morgan; Maria G Castro; Michael R H White; Julian R E Davis; Andrew S I Loudon
Photoperiodic regulation of prolactin gene expression in the Syrian hamster by a pars tuberalis-derived factor.
Journal of neuroendocrinology 2001;13(2):147-57.
2001: Julian R E Davis; J McVerry; Gerald A Lincoln; S Windeatt; Pedro R Lowenstein; Maria G Castro; Alan S McNeilly
Cell type-specific adenoviral transgene expression in the intact ovine pituitary gland after stereotaxic delivery: an in vivo system for long-term multiple parameter evaluation of human pituitary gene therapy.
Endocrinology 2001;142(2):795-801.
2001: C E Thomas; D Birkett; I Anozie; Maria G Castro; Pedro R Lowenstein
Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;3(1):36-46.
2001: Thomas D Southgate; D Stone; Judith C Williams; Pedro R Lowenstein; Maria G Castro
Long-term transgene expression within the anterior pituitary gland in situ: impact on circulating hormone levels, cellular and antibody-mediated immune responses.
Endocrinology 2001;142(1):464-76.
2000: JR Smith-Arica; Adrian E Morelli; Adriana T Larregina; J Smith; Pedro R Lowenstein; Maria G Castro
Cell-type-specific and regulatable transgenesis in the adult brain: adenovirus-encoded combined transcriptional targeting and inducible transgene expression.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;2(6):579-87.
2000: OA Brown; Rachel L Cowen; C M Preston; Maria G Castro; Pedro R Lowenstein
Subcellular post-transcriptional targeting: delivery of an intracellular protein to the extracellular leaflet of the plasma membrane using a glycosyl-phosphatidylinositol (GPI) membrane anchor in neurons and polarised epithelial cells.
Gene therapy 2000;7(22):1947-53.
2000: Christian A Gerdes; Maria G Castro; Pedro R Löwenstein
Strong promoters are the key to highly efficient, noninflammatory and noncytotoxic adenoviral-mediated transgene delivery into the brain in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;2(4):330-8.
2000: Maria G Castro; Rachel L Cowen; JR Smith-Arica; J Williams; S Ali; S Windeatt; V Gonzalez-Nicolini; TC Maleniak; Pedro R Lowenstein
Gene therapy strategies for intracranial tumours: glioma and pituitary adenomas.
Histology and histopathology 2000;15(4):1233-52.
2000: Thomas D Southgate; S Windeatt; JR Smith-Arica; Christian A Gerdes; Marcelo J Perone; Ian morris; Julian R E Davis; D Klatzmann; Pedro R Löwenstein; Maria G Castro
Transcriptional targeting to anterior pituitary lactotrophic cells using recombinant adenovirus vectors in vitro and in vivo in normal and estrogen/sulpiride-induced hyperplastic anterior pituitaries.
Endocrinology 2000;141(9):3493-505.
2000: Clare E Thomas; Gudrun Schiedner; Stefan Kochanek; Maria G Castro; Pedro R Löwenstein
Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: toward realistic long-term neurological gene therapy for chronic diseases.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7482-7.
2000: L M Carrington; Thomas D Southgate; L A Saxby; K Abul-Hassan; TC Maleniak; Maria G Castro; ME Boulton
Adenovirus-mediated gene transfer to human lens epithelial cells in organ culture.
Journal of cataract and refractive surgery 2000;26(6):887-92.
2000: Cécile Guillot; Patrick Mathieu; H Coathalem; Brigitte Le Mauff; Maria G Castro; Laurent Tesson; Claire Usal; T Laumonier; Sophie Brouard; Jean-Paul Soulillou; Pedro R Lowenstein; Maria Cristina Cuturi; Ignacio Anegon
Tolerance to cardiac allografts via local and systemic mechanisms after adenovirus-mediated CTLA4Ig expression.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(10):5258-68.
2000: CM Cowsill; Thomas D Southgate; Graham Morrissey; RA Dewey; Adrian E Morelli; TC Maleniak; Z Forrest; D Klatzmann; G W Wilkinson; Pedro R Löwenstein; Maria G Castro
Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase: reduced cytotoxicity of a truncated HSV1-TK.
Gene therapy 2000;7(8):679-85.
2000: S Windeatt; Thomas D Southgate; RA Dewey; F Bolognani; Marcelo J Perone; Adriana T Larregina; TC Maleniak; Ian morris; Rodolfo G Goya; D Klatzmann; Pedro R Löwenstein; Maria G Castro
Adenovirus-mediated herpes simplex virus type-1 thymidine kinase gene therapy suppresses oestrogen-induced pituitary prolactinomas.
The Journal of clinical endocrinology and metabolism 2000;85(3):1296-305.
2000: I Ahmed; BP Glynn; A V Perkins; Maria G Castro; J Rowe; E Morrison; EA Linton
Processing of procorticotropin-releasing hormone (pro-CRH): molecular forms of CRH in normal and preeclamptic pregnancy.
The Journal of clinical endocrinology and metabolism 2000;85(2):755-64.
2000: D Stone; A David; F Bolognani; Pedro R Lowenstein; Maria G Castro
Viral vectors for gene delivery and gene therapy within the endocrine system.
The Journal of endocrinology 2000;164(2):103-18.
1999: Thomas D Southgate; D Bain; Lynette D Fairbanks; Adrian E Morelli; Adriana T Larregina; H Anne Simmonds; Maria G Castro; Pedro R Löwenstein
Adenoviruses encoding HPRT correct biochemical abnormalities of HPRT-deficient cells and allow their survival in negative selection medium.
Metabolic brain disease 1999;14(4):205-21.
1999: Pedro R Lowenstein; Rachel L Cowen; C Thomas; Maria G Castro
The basic science of brain-tumour gene therapy.
Biochemical Society transactions 1999;27(6):873-81.
1999: Maria G Castro; S Windeatt; JR Smith-Arica; Pedro R Lowenstein
Cell-type specific expression in the pituitary: physiology and gene therapy.
Biochemical Society transactions 1999;27(6):858-63.
1999: P Tomasec; C M Preston; EA Linton; I Ahmed; Pedro R Lowenstein; Maria G Castro
Generation of a recombinant herpes simplex virus type 1 expressing the rat corticotropin- releasing hormone precursor: endoproteolytic processing, intracellular targeting and biological activity.
Neuroendocrinology 1999;70(6):439-50.
1999: RA Dewey; Graham Morrissey; CM Cowsill; D Stone; F Bolognani; N J Dodd; Thomas D Southgate; D Klatzmann; H Lassmann; Maria G Castro; Pedro R Löwenstein
Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials.
Nature medicine 1999;5(11):1256-63.
1999: Maria G Castro; J R Davis; Weidong Xiong; Pedro R Lowenstein
Recent developments in gene therapy: applications for the treatment of pituitary tumours.
Baillière's best practice & research. Clinical endocrinology & metabolism 1999;13(3):431-49.
1999: BB Ambar; K Frei; Ursula Malipiero; A E Morelli; Maria G Castro; Pedro R Lowenstein; Adriano Fontana
Treatment of experimental glioma by administration of adenoviral vectors expressing Fas ligand.
Human gene therapy 1999;10(10):1641-8.
1999: Pedro R Lowenstein; C E Thomas; Maria G Castro
Politically correct gene therapy? A "clean environment" improves gene delivery to the brain!
Gene therapy 1999;6(4):463-4.
1999: Adrian E Morelli; Adriana T Larregina; JR Smith-Arica; RA Dewey; Thomas D Southgate; BB Ambar; A Fontana; Maria G Castro; Pedro R Lowenstein
Neuronal and glial cell type-specific promoters within adenovirus recombinants restrict the expression of the apoptosis-inducing molecule Fas ligand to predetermined brain cell types, and abolish peripheral liver toxicity.
The Journal of general virology 1999;80 ( Pt 3)():571-83.
1999: T Cartmell; Thomas D Southgate; G S Rees; Maria G Castro; Pedro R Lowenstein; Giamal N Luheshi
Interleukin-1 mediates a rapid inflammatory response after injection of adenoviral vectors into the brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(4):1517-23.
1999: Maria G Castro
Gene therapy strategies for the treatment of pituitary tumours.
Journal of molecular endocrinology 1999;22(1):9-18.
1998: DJ Tellam; Marcelo J Perone; I C Dunn; Sally Radovick; John Brennand; J E Rivier; Maria G Castro; DA Lovejoy
Direct regulation of GnRH transcription by CRF-like peptides in an immortalized neuronal cell line.
Neuroreport 1998;9(14):3135-40.
1998: Marcelo J Perone; S Windeatt; E Morrison; AF Shering; P Tomasec; EA Linton; Pedro R Lowenstein; Maria G Castro
Intracellular retention of the corticotrophin-releasing hormone (CRH) precursor within COS-7 cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1998;46(10):1193-7.
1998: Marcelo J Perone; C A Murray; O A Brown; S Gibson; Anne White; EA Linton; A V Perkins; Pedro R Lowenstein; Maria G Castro
Procorticotrophin-releasing hormone: endoproteolytic processing and differential release of its derived peptides within AtT20 cells.
Molecular and cellular endocrinology 1998;142(1-2):191-202.
1998: Rodolfo G Goya; J Rowe; Yolanda E Sosa; P Tomasec; Pedro R Lowenstein; Maria G Castro
Use of recombinant herpes simplex virus type 1 vectors for gene transfer into tumour and normal anterior pituitary cells.
Molecular and cellular endocrinology 1998;139(1-2):199-207.
1998: Adriana T Larregina; Adrian E Morelli; RA Dewey; Maria G Castro; A Fontana; Pedro R Lowenstein
FasL induces Fas/Apo1-mediated apoptosis in human embryonic kidney 293 cells routinely used to generate E1-deleted adenoviral vectors.
Gene therapy 1998;5(4):563-8.
1998: Pedro R Lowenstein; Thomas D Southgate; JR Smith-Arica; J Smith; Maria G Castro
Gene therapy for inherited neurological disorders: towards therapeutic intervention in the Lesch-Nyhan syndrome.
Progress in brain research 1998;117():485-501.
1997: Marcelo J Perone; Maria G Castro
Prohormone and proneuropeptide synthesis and secretion.
Histology and histopathology 1997;12(4):1179-88.
1997: Marcelo J Perone; S Windeatt; Maria G Castro
Intracellular trafficking of prohormones and proneuropeptides: cell type-specific sorting and targeting.
Experimental physiology 1997;82(4):609-28.
1997: Maria G Castro; Rodolfo G Goya; Yolanda E Sosa; J Rowe; Adriana T Larregina; A Morelli; Pedro R Lowenstein
Expression of transgenes in normal and neoplastic anterior pituitary cells using recombinant adenoviruses: long term expression, cell cycle dependency, and effects on hormone secretion.
Endocrinology 1997;138(5):2184-94.
1997: OA Brown; R M Santer; AF Shering; Adriana T Larregina; Adrian E Morelli; Thomas D Southgate; Maria G Castro; Pedro R Lowenstein
Gene transfer into enteric neurons of the rat small intestine in organ culture using a replication defective recombinant herpes simplex virus type 1 (HSV1) vector, but not recombinant adenovirus vectors.
Gene therapy 1997;4(4):331-8.
1997: AF Shering; D Bain; K Stewart; A L Epstein; Maria G Castro; G W Wilkinson; Pedro R Lowenstein
Cell type-specific expression in brain cell cultures from a short human cytomegalovirus major immediate early promoter depends on whether it is inserted into herpesvirus or adenovirus vectors.
The Journal of general virology 1997;78 ( Pt 2)():445-59.
1997: K Stewart; OA Brown; Adrian E Morelli; Leslie J Fairbairn; Linda S Lashford; A Cooper; C E Hatton; TM Dexter; Maria G Castro; Pedro R Lowenstein
Uptake of alpha-(L)-iduronidase produced by retrovirally transduced fibroblasts into neuronal and glial cells in vitro.
Gene therapy 1997;4(1):63-75.
1996: Marcelo J Perone; I Ahmed; EA Linton; Maria G Castro
Procorticotrophin releasing hormone is endoproteolytically processed by the prohormone convertase PC2 but not by PC1 within stably transfected CHO-K1 cells.
Biochemical Society transactions 1996;24(3):497S.
1996: Maria G Castro; E Morrison; Marcelo J Perone; Oscar A Brown; C A Murray; I Ahmed; A V Perkins; G Europe-Finner; Pedro R Lowenstein; EA Linton
Corticotrophin-releasing hormone receptor type 1: generation and characterization of polyclonal antipeptide antibodies and their localization in pituitary cells and cortical neurones in vitro.
Journal of neuroendocrinology 1996;8(7):521-31.
1995: Maria G Castro; E Morrison; P Tomasec; EA Linton; Pedro R Lowenstein
Co-localisation of autoimmune antibodies specific for double stranded DNA with procorticotrophin-releasing hormone within the nucleus of stably transfected CHO-K1 cells.
Cell and tissue research 1995;282(3):367-76.
1995: Maria G Castro; J M Rowe; C A Murray; P Tomasec; A F Shering; EA Linton; I Ahmed; Pedro R Lowenstein
Generation and characterization of an antiserum reactive with a proteolytic processing site within rat procorticotrophin-releasing hormone.
Neuropeptides 1995;29(4):183-92.
1995: Pedro R Lowenstein; S Fournel; D Bain; P Tomasec; P M Clissold; Maria G Castro; A L Epstein
Simultaneous detection of amplicon and HSV-1 helper encoded proteins reveals that neurons and astrocytoma cells do express amplicon-borne transgenes in the absence of synthesis of virus immediate early proteins.
Brain research. Molecular brain research 1995;30(1):169-75.
1995: E Morrison; P Tomasec; EA Linton; P J Lowry; Pedro R Lowenstein; Maria G Castro
Expression of biologically active procorticotrophin-releasing hormone (proCRH) in stably transfected CHO-K1 cells: characterization of nuclear proCRH.
Journal of neuroendocrinology 1995;7(4):263-72.
1995: Pedro R Lowenstein; A F Shering; E Morrison; P Tomasec; D Bain; T J Jacob; J Wu; A Prescott; Maria G Castro
Synaptogenesis and distribution of presynaptic axonal varicosities in low density primary cultures of neocortex: an immunocytochemical study utilizing synaptic vesicle-specific antibodies, and an electrophysiological examination utilizing whole cell recording.
Journal of neurocytology 1995;24(4):301-17.
1994: Pedro R Lowenstein; Ewan E Morrison; D Bain; A F Shering; George Banting; P Douglas; Maria G Castro
Polarized distribution of the trans-Golgi network marker TGN38 during the in vitro development of neocortical neurons: effects of nocodazole and brefeldin A.
The European journal of neuroscience 1994;6(9):1453-65.
1994: Pedro R Lowenstein; S Fournel; D Bain; P Tomasec; P Clissold; Maria G Castro; A L Epstein
Herpes simplex virus 1 (HSV-1) helper co-infection affects the distribution of an amplicon encoded protein in glia.
Neuroreport 1994;5(13):1625-30.
1994: Pedro R Lowenstein; Ewan E Morrison; D Bain; P Hodge; Chris M Preston; P Clissold; Nigel D Stow; T A McKee; Maria G Castro
Use of recombinant vectors derived from herpes simplex virus 1 mutant tsK for short-term expression of transgenes encoding cytoplasmic and membrane anchored proteins in postmitotic polarized cortical neurons and glial cells in vitro.
Neuroscience 1994;60(4):1059-77.
1994: D Bain; Gavin W G Wilkinson; Chris M Preston; Maria G Castro; Pedro R Lowenstein
Adenovirus vectors to transfer genes into neurones: implications for gene therapy of neurological disorders.
Gene therapy 1994;1 Suppl 1():S68.
1994: P Tomasec; Pedro R Lowenstein; E Morrison; P Hodge; EA Linton; A Perkins; P J Lowry; Maria G Castro
Use of gene transfer to study post-translational modifications of neuropeptides in cell lines.
Gene therapy 1994;1 Suppl 1():S64.
1994: E Morrison; Pedro R Lowenstein; P Hodge; EA Linton; P J Lowry; Y Corredoira; Maria G Castro
Nuclear and cytoplasmic localisation of procorticotrophin releasing hormone in transfected CHO-K1 cells.
Gene therapy 1994;1 Suppl 1():S62.
1994: Pedro R Lowenstein; D Bain; Ewan E Morrison; Chris M Preston; P Clissold; S Fournel; A Epstein; Maria G Castro
HSV1 vectors to study protein targeting in neurones: are glycosyl-phosphatidylinositol anchors polarized targeting signals in neurones?
Gene therapy 1994;1 Suppl 1():S32-5.
1994: Maria G Castro; P Hodge; Y A Corredoira; E Morrison; P Tomasec; C A Murray; Pedro R Lowenstein
Neuropeptide gene transfer into neuronal and glial cell lines.
Gene therapy 1994;1 Suppl 1():S15-8.
1993: E Morrison; P Hodge; P Tomasec; Pedro R Lowenstein; EA Linton; P J Lowry; Maria G Castro
Nuclear localisation of corticotrophin releasing hormone (CRH) in transfected CHO-K1 cells.
Biochemical Society transactions 1993;21 ( Pt 3)(3):318S.
1993: Rodolfo G Goya; Maria G Castro; EA Linton; Russell J Woods; Yolanda E Sosa; Philip J Lowry
Histones and related preparations interfere with immunoassays for peptide hormones.
Peptides 1993;14(4):777-81.
1993: Pedro R Lowenstein; E Morrison; P Douglas; Chris M Preston; P Clissold; George Banting; Nigel D Stow; Maria G Castro
Neocortical neuronal polarity: targeting of a foreign protein linked to a glycosyl-phosphatidylinositol (GPI) anchor in postmitotic neurons and polarized distribution of a marker of the trans-Golgi network (TGN 38).
Biochemical Society transactions 1993;21(2):117S.
1993: E Morrison; Pedro R Lowenstein; P Tomasec; P Hodge; EA Linton; J Devine; P J Lowry; Maria G Castro
Intracellular compartmentalisation of procorticotrophin releasing hormone.
Biochemical Society transactions 1993;21(1):47S.
1993: Pedro R Lowenstein; E Morrison; P Hodge; P Tomasec; A F Shering; Nigel D Stow; Chris M Preston; J L James; Maria G Castro
Polarity development and synaptogenesis in low density primary cultures of neocortex. Use of herpes simplex virus-1 vectors to transfer genes into postmitotic neurons.
Biochemical Society transactions 1993;21(1):14S.
1993: Rodolfo G Goya; Maria G Castro; M J Hannah; Yolanda E Sosa; Philip J Lowry
Thymosin peptides stimulate corticotropin release by a calcium-dependent mechanism.
Neuroendocrinology 1993;57(2):230-5.
1993: Rodolfo G Goya; Maria G Castro; Peter Saphier; Yolanda E Sosa; Philip J Lowry
Thymus-pituitary interactions during ageing.
Age and ageing 1993;22(1):S19-25.
1993: Rodolfo G Goya; Maria G Castro; M J Hannah; Yolanda E Sosa; Philip J Lowry
Corticotropin-releasing (CRH) activity of thymic peptides on CRH-insensitive corticotropic tumor cells.
Medicina 1993;53(2):108-12.
1992: Maria G Castro; Philip J Lowry; P R Lowenstein
Antibodies to neuropeptide precursors expressed as fusion proteins in E. coli. Their use to examine neuropeptide biosynthetic pathways, intracellular trafficking and physiological activities.
The International journal of biochemistry 1992;24(6):847-60.
1991: Maria G Castro; J Brooke; A Bullman; M Hannah; B P Glynn; Philip J Lowry
Biosynthesis of corticotrophin-releasing hormone (CRH) in mouse corticotrophic tumour cells expressing the human proCRH gene: intracellular storage and regulated secretion.
Journal of molecular endocrinology 1991;7(2):97-104.
1991: M S Gilbert; Philip J Lowry; Maria G Castro; R J Woods; Demetris Savva
Expression and partial purification of human prolactin in Escherichia coli.
The International journal of biochemistry 1991;23(1):107-14.
1990: Maria G Castro; P R Lowenstein; Peter Saphier; EA Linton; Philip J Lowry
The use of inclusion bodies, isolated from Escherichia coli expressing corticotrophin-releasing hormone precursor, to raise specific antibodies against the neuropeptide moiety.
Journal of molecular endocrinology 1990;5(3):221-30.
1990: Maria G Castro; A P Bullman; J E Brooke; P J Lowry
Production and release of corticotropin releasing hormone (CRH) from AtT-20 cells stably transfected with the human CRH gene.
Biochemical Society transactions 1990;18(6):1250-1.
1990: Maria G Castro; B A Spruce; Demetris Savva; Philip J Lowry
Expression of biologically active human pre-procorticotropin releasing hormone in E. coli: characterization and purification.
The International journal of biochemistry 1990;22(11):1341-9.