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Rui Castro

Research Profile

Chemicals & Drugs

Living Beings

Anatomy

Procedures

In Situ Nick End Labelling

Disorders

Fatty Liver

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Publications

TOP 3
Rui E Castro; Helena Cortez-Pinto; Duarte M S Ferreira; Mariana V Machado; Marta B Afonso; Pedro Borralho; Cecília M P Rodrigues
miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease.
Rui E Castro; Cecília M P Rodrigues
Targeting miR-506 in primary biliary cirrhosis to support the HCO3- umbrella.
Mariana Verdelho Machado; Cecília M P Rodrigues; Ana Rita Silvestre; Fátima Carepa; Rui E Castro; Adília Costa; João Coutinho; Teresinha Evangelista; Duarte M S Ferreira; Helena Cortez-Pinto
Liver and muscle in morbid obesity: the interplay of fatty liver and insulin resistance.

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All Publications

2013: Rui E Castro; Helena Cortez-Pinto; Duarte M S Ferreira; Mariana V Machado; Marta B Afonso; Pedro Borralho; Cecília M P Rodrigues
miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease.
Journal of hepatology 2013;58(1):119-25.
2012: Rui E Castro; Cecília M P Rodrigues
Targeting miR-506 in primary biliary cirrhosis to support the HCO3- umbrella.
Clinics and research in hepatology and gastroenterology 2012;36(5):402-4.
2012: Mariana Verdelho Machado; Cecília M P Rodrigues; Ana Rita Silvestre; Fátima Carepa; Rui E Castro; Adília Costa; João Coutinho; Teresinha Evangelista; Duarte M S Ferreira; Helena Cortez-Pinto
Liver and muscle in morbid obesity: the interplay of fatty liver and insulin resistance.
PloS one 2012;7(2):e31738.
2011: D M S Ferreira; M V Machado; A Silvestre; F Carepa; Rui E Castro; Helena Cortez-Pinto; A Costa; J Coutinho; Teresinha Evangelista; C M P Rodrigues
Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease.
Diabetologia 2011;54(7):1788-98.
2011: Pedro Borralho; Tânia Carvalho; Rui E Castro; Duarte M S Ferreira; Sofia E Gomes; Raquel T Lima; André E S Simões; Maria H Vasconcelos; Cecília M P Rodrigues
miR-143 overexpression impairs growth of human colon carcinoma xenografts in mice with induction of apoptosis and inhibition of proliferation.
PloS one 2011;6(8):e23787.
2010: Joana D Amaral; Rui E Castro; Susana Solá; Clifford J Steer; Cecília M P Rodrigues
Ursodeoxycholic acid modulates the ubiquitin-proteasome degradation pathway of p53.
Biochemical and biophysical research communications 2010;400(4):649-54.
2010: Rui E Castro; Duarte M S Ferreira; Xiaoxiao Zhang; Pedro Borralho; Aaron L Sarver; Yan Zeng; Clifford J Steer; Betsy T Kren; Cecília M P Rodrigues
Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid.
American journal of physiology. Gastrointestinal and liver physiology 2010;299(4):G887-97.
2010: Rui E Castro; Maria M M Santos; Paulo M C Glória; Carlos J A Ribeiro; Duarte M S Ferreira; Joana M Xavier; Rui Moreira; Cecília M P Rodrigues
Cell death targets and potential modulators in Alzheimer's disease.
Current pharmaceutical design 2010;16(25):2851-64.
2009: Pedro M Borralho; Betsy T Kren; Rui E Castro; Isabel B Moreira da Silva; Clifford J Steer; Cecília M P Rodrigues
MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cells.
The FEBS journal 2009;276(22):6689-700.
2009: Joana D Amaral; Rui E Castro; Clifford J Steer; Cecília M P Rodrigues
p53 and the regulation of hepatocyte apoptosis: implications for disease pathogenesis.
Trends in molecular medicine 2009;15(11):531-41.
2009: Daniela M Santos; Maria M M Santos; Ricardo J S Viana; Rui E Castro; Rui Moreira; Cecília M P Rodrigues
Naphtho[2,3-d]isoxazole-4,9-dione-3-carboxylates: potent, non-cytotoxic, antiapoptotic agents.
Chemico-biological interactions 2009;180(2):175-82.
2009: R J S Viana; A F Nunes; Rui E Castro; Rita M Ramalho; J Meyerson; S Fossati; Jorge Ghiso; Agueda Rostagno; Cecília M P Rodrigues
Tauroursodeoxycholic acid prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells.
Cellular and molecular life sciences : CMLS 2009;66(6):1094-104.
2008: Rita M Ramalho; Ricardo J S Viana; Rui E Castro; Clifford J Steer; Walter C Low; Cecília M P Rodrigues
Apoptosis in transgenic mice expressing the P301L mutated form of human tau.
Molecular medicine (Cambridge, Mass.) 2008;14(5-6):309-17.
2007: Joana D Amaral; Rui E Castro; Susana Solá; Clifford J Steer; Cecília M P Rodrigues
p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis.
The Journal of biological chemistry 2007;282(47):34250-9.
2007: GM Ferreira-Dias; L Mateus; A S Costa; Susana Solá; Rita M Ramalho; Rui E Castro; Cecília M P Rodrigues
Progesterone and caspase-3 activation in equine cyclic corpora lutea.
Reproduction in domestic animals = Zuchthygiene 2007;42(4):380-6.
2007: Rui E Castro; Joana D Amaral; Susana Solá; Betsy T Kren; Clifford J Steer; Cecília M P Rodrigues
Differential regulation of cyclin D1 and cell death by bile acids in primary rat hepatocytes.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(1):G327-34.
2007: Andrew Rivard; Clifford J Steer; Betsy T Kren; Cecília M P Rodrigues; Rui E Castro; Richard W Bianco; Walter C Low
Administration of tauroursodeoxycholic acid (TUDCA) reduces apoptosis following myocardial infarction in rat.
The American journal of Chinese medicine 2007;35(2):279-95.
2006: Susana Solá; Joana D Amaral; Pedro Borralho; Rita M Ramalho; Rui E Castro; Márcia M Aranha; Clifford J Steer; Cecília M P Rodrigues
Functional modulation of nuclear steroid receptors by tauroursodeoxycholic acid reduces amyloid beta-peptide-induced apoptosis.
Molecular endocrinology (Baltimore, Md.) 2006;20(10):2292-303.
2006: Rita M Ramalho; Pedro Borralho; Rui E Castro; Susana Solá; Clifford J Steer; Cecília M P Rodrigues
Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells.
Journal of neurochemistry 2006;98(5):1610-8.
2006: Rita M Ramalho; Helena Cortez-Pinto; Rui E Castro; Susana Solá; Adília Costa; Miguel C Moura; Maria Ermelinda Camilo; Cecília M P Rodrigues
Apoptosis and Bcl-2 expression in the livers of patients with steatohepatitis.
European journal of gastroenterology & hepatology 2006;18(1):21-9.
2005: Susana Solá; Joana D Amaral; Rui E Castro; Rita M Ramalho; Pedro Borralho; Betsy T Kren; Hirotoshi Tanaka; Clifford J Steer; Cecília M P Rodrigues
Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta1-induced apoptosis in rat hepatocytes.
Hepatology (Baltimore, Md.) 2005;42(4):925-34.
2005: Rui E Castro; Susana Solá; Xiaoming Ma; Rita M Ramalho; Betsy T Kren; Clifford J Steer; Cecília M P Rodrigues
A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeoxycholic acid.
Journal of hepatology 2005;42(6):897-906.
2004: Rui E Castro; Susana Solá; Rita M Ramalho; Clifford J Steer; Cecília M P Rodrigues
The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of bad via phosphatidylinositol 3-kinase in glutamate-induced apoptosis of rat cortical neurons.
The Journal of pharmacology and experimental therapeutics 2004;311(2):845-52.
2004: Paulo S Ribeiro; Helena Cortez-Pinto; Susana Solá; Rui E Castro; Rita M Ramalho; Amélia Baptista; Miguel C Moura; Maria Ermelinda Camilo; Cecília M P Rodrigues
Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients.
The American journal of gastroenterology 2004;99(9):1708-17.
2004: Rita M Ramalho; Paulo S Ribeiro; Susana Solá; Rui E Castro; Clifford J Steer; Cecília M P Rodrigues
Inhibition of the E2F-1/p53/Bax pathway by tauroursodeoxycholic acid in amyloid beta-peptide-induced apoptosis of PC12 cells.
Journal of neurochemistry 2004;90(3):567-75.
2004: Susana Solá; Rui E Castro; Betsy T Kren; Clifford J Steer; Cecília M P Rodrigues
Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-beta1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes.
Biochemistry 2004;43(26):8429-38.
2003: Susana Sola; Xiaoming Ma; Rui E Castro; Betsy T Kren; Clifford J Steer; Cecília M P Rodrigues
Ursodeoxycholic acid modulates E2F-1 and p53 expression through a caspase-independent mechanism in transforming growth factor beta1-induced apoptosis of rat hepatocytes.
The Journal of biological chemistry 2003;278(49):48831-8.
2003: Susana Solá; Rui E Castro; Pedro Laires; Clifford J Steer; Cecília M P Rodrigues
Tauroursodeoxycholic acid prevents amyloid-beta peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathway.
Molecular medicine (Cambridge, Mass.) 2003;9(9-12):226-34.
2003: Cecília M P Rodrigues; Susana Sola; Zhenhong Nan; Rui E Castro; Paulo S Ribeiro; Walter C Low; Clifford J Steer
Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):6087-92.
2002: Cecília M P Rodrigues; Susana Solá; Rui E Castro; Pedro Laires; Dora Brites; José J G Moura
Perturbation of membrane dynamics in nerve cells as an early event during bilirubin-induced apoptosis.
Journal of lipid research 2002;43(6):885-94.