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SEKHAR KONJETI

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Sharron H Francis; SEKHAR KONJETI; Hengming Ke; Jackie D Corbin
Inhibition of cyclic nucleotide phosphodiesterases by methylxanthines and related compounds.
Amudhan Venkateswaran; Y Thirupathi Reddy; Vijayakumar N Sonar; Venkatraj Muthusamy; Peter A Crooks; Michael L Freeman; SEKHAR KONJETI
Antiangiogenic properties of substituted (Z)-(±)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol/one analogs and their derivatives.
Rory Pruitt; Nidhish Sasi; Michael L Freeman; SEKHAR KONJETI
Radiosensitization of cancer cells by hydroxychalcones.

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All Publications

2011: Sharron H Francis; SEKHAR KONJETI; Hengming Ke; Jackie D Corbin
Inhibition of cyclic nucleotide phosphodiesterases by methylxanthines and related compounds.
Handbook of experimental pharmacology 2011;(200):93-133.
2010: Amudhan Venkateswaran; Y Thirupathi Reddy; Vijayakumar N Sonar; Venkatraj Muthusamy; Peter A Crooks; Michael L Freeman; SEKHAR KONJETI
Antiangiogenic properties of substituted (Z)-(±)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol/one analogs and their derivatives.
Bioorganic & medicinal chemistry letters 2010;20(24):7323-6.
2010: Rory Pruitt; Nidhish Sasi; Michael L Freeman; SEKHAR KONJETI
Radiosensitization of cancer cells by hydroxychalcones.
Bioorganic & medicinal chemistry letters 2010;20(20):5997-6000.
2010: G Rachakonda; SEKHAR KONJETI; D Jowhar; P C Samson; J P Wikswo; R D Beauchamp; P K Datta; M L Freeman
Increased cell migration and plasticity in Nrf2-deficient cancer cell lines.
Oncogene 2010;29(25):3703-14.
2010: SEKHAR KONJETI; Girish Rachakonda; Michael L Freeman
Cysteine-based regulation of the CUL3 adaptor protein Keap1.
Toxicology and applied pharmacology 2010;244(1):21-6.
2010: Y Thirupathi Reddy; SEKHAR KONJETI; Nidhish Sasi; P Narsimha Reddy; Michael L Freeman; Peter A Crooks
Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones as potent radio-sensitizing agents.
Bioorganic & medicinal chemistry letters 2010;20(2):600-2.
2009: Ling Geng; Girish Rachakonda; D James Morré; Dorothy M Morré; Peter A Crooks; Vijayakumar N Sonar; Joseph L Roti Roti; Buck E Rogers; Suellen Greco; Fei Ye; Kenneth J Salleng; Soumya Sasi; Michael L Freeman; SEKHAR KONJETI
Indolyl-quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation-mediated control of tumor vasculature.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(9):2986-95.
2008: Girish Rachakonda; Ying Xiong; SEKHAR KONJETI; Sheryl L Stamer; Daniel C Liebler; Michael L Freeman
Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3.
Chemical research in toxicology 2008;21(3):705-10.
2008: Stephan L Brown; SEKHAR KONJETI; Girish Rachakonda; Soumya Sasi; Michael L Freeman
Activating transcription factor 3 is a novel repressor of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2)-regulated stress pathway.
Cancer research 2008;68(2):364-8.
2007: Vijayakumar N Sonar; Y Thirupathi Reddy; SEKHAR KONJETI; Soumya Sasi; Michael L Freeman; Peter A Crooks
Novel substituted (Z)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-one and (Z)-(+/-)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol derivatives as potent thermal sensitizing agents.
Bioorganic & medicinal chemistry letters 2007;17(24):6821-4.
2007: Ling Gao; Jiakun Wang; SEKHAR KONJETI; Huiyong Yin; Nicholas F Yared; Scott N Schneider; Soumya Sasi; Timothy P Dalton; Mark E Anderson; Jefferson Y Chan; Jason D Morrow; Michael L Freeman
Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3.
The Journal of biological chemistry 2007;282(4):2529-37.
2007: SEKHAR KONJETI; Vijayakumar N Sonar; Venkatraj Muthusamy; Soumya Sasi; Andrei Laszlo; Jamil Sawani; Nobuo Horikoshi; Ryuji Higashikubo; Robert G Bristow; Michael J Borrelli; Peter A Crooks; James R Lepock; Joseph L Roti Roti; Michael L Freeman
Novel chemical enhancers of heat shock increase thermal radiosensitization through a mitotic catastrophe pathway.
Cancer research 2007;67(2):695-701.
2006: Kwang Woon Kim; Robert W Mutter; Carolyn Cao; Jeffrey M Albert; Eric T Shinohara; SEKHAR KONJETI; Bo Lu
Inhibition of signal transducer and activator of transcription 3 activity results in down-regulation of Survivin following irradiation.
Molecular cancer therapeutics 2006;5(11):2659-65.
2006: Carolyn Cao; Ty K Subhawong; Jeffrey M Albert; Kwang Woon Kim; Ling Geng; SEKHAR KONJETI; Young Jin Gi; Bo Lu
Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells.
Cancer research 2006;66(20):10040-7.
2006: Donnie R Stacy; Kim Ely; Pierre P Massion; Wendell G Yarbrough; Dennis E Hallahan; SEKHAR KONJETI; Michael L Freeman
Increased expression of nuclear factor E2 p45-related factor 2 (NRF2) in head and neck squamous cell carcinomas.
Head & neck 2006;28(9):813-8.
2005: Carolyn Cao; Eric T Shinohara; Hecheng Li; Kenneth J Niermann; Kwang Woon Kim; SEKHAR KONJETI; Martin Gleave; Michael Freeman; Bo Lu
Clusterin as a therapeutic target for radiation sensitization in a lung cancer model.
International journal of radiation oncology, biology, physics 2005;63(4):1228-36.
2005: Fei Hong; SEKHAR KONJETI; Michael Freenan; Daniel C Liebler
Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation.
The Journal of biological chemistry 2005;280(36):31768-75.
2005: Andrei V Bakin; Nina V Stourman; SEKHAR KONJETI; Cammie Rinehart; Xuexian Yan; Michael J (Michael) Meredith; Carlos L Arteaga; Michael L Freeman
Smad3-ATF3 signaling mediates TGF-beta suppression of genes encoding Phase II detoxifying proteins.
Free radical biology & medicine 2005;38(3):375-87.
2005: James Weeks; Mitsi A Blount; Alfreda Beasley; Roya Zoraghi; Melissa K Thomas; SEKHAR KONJETI; Jackie D Corbin; Sharron H Francis
Radiolabeled ligand binding to the catalytic or allosteric sites of PDE5 and PDE11.
Methods in molecular biology (Clifton, N.J.) 2005;307():239-62.
2005: James Weeks; Roya Zoraghi; Alfreda Beasley; SEKHAR KONJETI; Sharron H Francis; Jackie D Corbin
High biochemical selectivity of tadalafil, sildenafil and vardenafil for human phosphodiesterase 5A1 (PDE5) over PDE11A4 suggests the absence of PDE11A4 cross-reaction in patients.
International journal of impotence research 2005;17(1):5-9.
2004: Mitsi A Blount; Alfreda Beasley; Roya Zoraghi; SEKHAR KONJETI; Emmanuel Bessay; Sharron H Francis; Jackie D Corbin
Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation.
Molecular pharmacology 2004;66(1):144-52.
2003: Debabrata Saha; SEKHAR KONJETI; Carolyn Cao; Jason D Morrow; Hak Choy; Michael L Freeman
The antiangiogenic agent SU5416 down-regulates phorbol ester-mediated induction of cyclooxygenase 2 expression by inhibiting nicotinamide adenine dinucleotide phosphate oxidase activity.
Cancer research 2003;63(20):6920-7.
2003: Sharron H Francis; SEKHAR KONJETI; A B Rouse; Kennard A Grimes; Jackie D Corbin
Single step isolation of sildenafil from commercially available Viagra tablets.
International journal of impotence research 2003;15(5):369-72.
2003: SEKHAR KONJETI; Peter A Crooks; Vijayakumar N Sonar; David B Friedman; Jefferson Y Chan; Michael J (Michael) Meredith; Joseph H Starnes; Kathy R Kelton; Samantha R Summar; Soumya Sasi; Michael L Freeman
NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols.
Cancer research 2003;63(17):5636-45.
2002: SEKHAR KONJETI; Xue Xian Yan; Michael L Freeman
Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2.
Oncogene 2002;21(44):6829-34.
2002: SEKHAR KONJETI; Douglas R Spitz; Stephanie Harris; Trung T Nguyen; Michael J (Michael) Meredith; Jeffrey T Holt; David Gius; Lawrence J Marnett; Marshall Summar; Michael L Freeman; David Guis
Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase.
Free radical biology & medicine 2002;32(7):650-62.
2000: SEKHAR KONJETI; SR Soltaninassab; Michael J Borrelli; ZQ Xu; Michael J (Michael) Meredith; F E Domann; Michael L Freeman
Inhibition of the 26S proteasome induces expression of GLCLC, the catalytic subunit for gamma-glutamylcysteine synthetase.
Biochemical and biophysical research communications 2000;270(1):311-7.
2000: SR Soltaninassab; SEKHAR KONJETI; Michael J (Michael) Meredith; Michael L Freeman
Multi-faceted regulation of gamma-glutamylcysteine synthetase.
Journal of cellular physiology 2000;182(2):163-70.
1999: SEKHAR KONJETI; Michael L Freeman
Autophosphorylation inhibits the activity of gamma-glutamylcysteine synthetase.
Journal of enzyme inhibition 1999;14(4):323-30.
1998: SEKHAR KONJETI; M L Freeman
PEST sequences in proteins involved in cyclic nucleotide signalling pathways.
Journal of receptor and signal transduction research 1998;18(2-3):113-32.
1998: Jackie D Corbin; Alfreda Beasley; IV Turko; TL Haik; K A Mangum; JN Wells; Sharron H Francis; SEKHAR KONJETI
A photoaffinity probe covalently modifies the catalytic site of the cGMP-binding cGMP-specific phosphodiesterase (PDE-5).
Cell biochemistry and biophysics 1998;29(1-2):145-57.
1997: GA Senisterra; SA Huntley; M Escaravage; SEKHAR KONJETI; Michael L Freeman; Michael J Borrelli; James R Lepock
Destabilization of the Ca2+-ATPase of sarcoplasmic reticulum by thiol-specific, heat shock inducers results in thermal denaturation at 37 degrees C.
Biochemistry 1997;36(36):11002-11.
1997: SEKHAR KONJETI; Michael J (Michael) Meredith; LD Kerr; SR Soltaninassab; D R Spitz; ZQ Xu; Michael L Freeman
Expression of glutathione and gamma-glutamylcysteine synthetase mRNA is Jun dependent.
Biochemical and biophysical research communications 1997;234(3):588-93.
1997: SEKHAR KONJETI; M Long; J Long; ZQ Xu; Marshall Summar; Michael L Freeman
Alteration of transcriptional and post-transcriptional expression of gamma-glutamylcysteine synthetase by diethyl maleate.
Radiation research 1997;147(5):592-7.
1997: A T McDuffee; GA Senisterra; SA Huntley; James R Lepock; SEKHAR KONJETI; Michael J (Michael) Meredith; Michael J Borrelli; J D Morrow; Michael L Freeman
Proteins containing non-native disulfide bonds generated by oxidative stress can act as signals for the induction of the heat shock response.
Journal of cellular physiology 1997;171(2):143-51.
1993: Jackie D Corbin; C C Woodall; J L Colbran; Linda M McAllister-Lucas; SEKHAR KONJETI; Sharron H Francis
Identifying protein kinases in crude extracts that phosphorylate cyclic GMP-binding cyclic-GMP specific phosphodiesterase.
Agents and actions. Supplements 1993;43():27-33.
1992: SEKHAR KONJETI; R J Hatchett; J B Shabb; L Wolfe; Sharron H Francis; J N Wells; B Jastorff; E Butt; M M Chakinala; Jackie D Corbin
Relaxation of pig coronary arteries by new and potent cGMP analogs that selectively activate type I alpha, compared with type I beta, cGMP-dependent protein kinase.
Molecular pharmacology 1992;42(1):103-8.