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David Siderovski

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Dustin E Bosch; Adam Jordan Kimple; Mischa Machius; Alyssa J Manning; Robin E Muller; Stephen L Rogers; Francis S Willard; David Siderovski
Structural determinants of RGS-RhoGEF signaling critical to Entamoeba histolytica pathogenesis.
Staci P Cohen; Alaina L Garland; Vadim Y Arshavsky; Dustin E Bosch; Michael D Brown; Brian K Buckley; Gang Cheng; Mickey Kosloff; Harish Radhakrishna; David Siderovski; Robert Tarran; Francis S Willard; Adam Jordan Kimple
Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia.
Dustin E Bosch; Robert G Lowery; Thomas Zielinski; David Siderovski
Evaluating modulators of "Regulator of G-protein Signaling" (RGS) proteins.

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All Publications

2013: Dustin E Bosch; Adam Jordan Kimple; Mischa Machius; Alyssa J Manning; Robin E Muller; Stephen L Rogers; Francis S Willard; David Siderovski
Structural determinants of RGS-RhoGEF signaling critical to Entamoeba histolytica pathogenesis.
Structure (London, England : 1993) 2013;21(1):65-75.
2012: Staci P Cohen; Alaina L Garland; Vadim Y Arshavsky; Dustin E Bosch; Michael D Brown; Brian K Buckley; Gang Cheng; Mickey Kosloff; Harish Radhakrishna; David Siderovski; Robert Tarran; Francis S Willard; Adam Jordan Kimple
Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia.
The Journal of biological chemistry 2012;287(50):41706-19.
2012: Dustin E Bosch; Robert G Lowery; Thomas Zielinski; David Siderovski
Evaluating modulators of "Regulator of G-protein Signaling" (RGS) proteins.
Current protocols in pharmacology / editorial board, S.J. Enna (editor-in-chief) ... [et al.] 2012;Chapter 2():Unit2.8.
2012: Dustin E Bosch; Adam Jordan Kimple; Naweed I Naqvi; Ravikrishna Ramanujam; Francis S Willard; Melinda D Willard; David Siderovski
A P-loop mutation in Gα subunits prevents transition to the active state: implications for G-protein signaling in fungal pathogenesis.
PLoS pathogens 2012;8(2):e1002553.
2011: Adam Jordan Kimple; Dustin E Bosch; Patrick M Giguère; David Siderovski
Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets.
Pharmacological reviews 2011;63(3):728-49.
2011: Deanne W Sammond; Dustin E Bosch; Glenn L Butterfoss; Carrie Purbeck; Mischa Machius; David Siderovski; Brian Kuhlman
Computational design of the sequence and structure of a protein-binding peptide.
Journal of the American Chemical Society 2011;133(12):4190-2.
2011: Dustin E Bosch; Adam Jordan Kimple; Deanne W Sammond; Robin E Muller; Michael J Miley; Mischa Machius; Brian Kuhlman; Francis S Willard; David Siderovski
Structural determinants of affinity enhancement between GoLoco motifs and G-protein alpha subunit mutants.
The Journal of biological chemistry 2011;286(5):3351-8.
2010: Robin E Muller; Klara R Klein; Stephanie Q Hutsell; David Siderovski; Adam Jordan Kimple
A homogeneous method to measure nucleotide exchange by α-subunits of heterotrimeric G-proteins using fluorescence polarization.
Assay and drug development technologies 2010;8(5):621-4.
2010: Geneviève Laroche; Patrick M Giguère; Bryan L Roth; JoAnn Trejo; David Siderovski
RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling.
American journal of physiology. Cell physiology 2010;299(3):C654-64.
2010: Zhen Zheng; Huabin Zhu; Qingwen Wan; Jing Liu; Zhuoni Xiao; David Siderovski; Quansheng Du
LGN regulates mitotic spindle orientation during epithelial morphogenesis.
The Journal of cell biology 2010;189(2):275-88.
2010: Nevin A Lambert; Christopher A Johnston; Steven D Cappell; Sudhakiranmayi Kuravi; Adam Jordan Kimple; Francis S Willard; David Siderovski
Regulators of G-protein signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(15):7066-71.
2010: Kazuhiro Nakamura; Adam Jordan Kimple; David Siderovski; Gary L Johnson
PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation.
The Journal of biological chemistry 2010;285(3):2077-89.
2010: Adam Jordan Kimple; Robin E Muller; David Siderovski; Francis S Willard
A capture coupling method for the covalent immobilization of hexahistidine tagged proteins for surface plasmon resonance.
Methods in molecular biology (Clifton, N.J.) 2010;627():91-100.
2010: Stephanie Q Hutsell; Randall J Kimple; David Siderovski; Francis S Willard; Adam Jordan Kimple
High-affinity immobilization of proteins using biotin- and GST-based coupling strategies.
Methods in molecular biology (Clifton, N.J.) 2010;627():75-90.
2009: Thomas Zielinski; Adam Jordan Kimple; Stephanie Q Hutsell; Mark D Koeff; David Siderovski; Robert G Lowery
Two Galpha(i1) rate-modifying mutations act in concert to allow receptor-independent, steady-state measurements of RGS protein activity.
Journal of biomolecular screening 2009;14(10):1195-206.
2009: Adam Jordan Kimple; Meera Soundararajan; Stephanie Q Hutsell; Annette K Roos; Daniel J Urban; Vincent Setola; Brenda Temple; Bryan L Roth; Stefan Knapp; Francis S Willard; David Siderovski
Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2).
The Journal of biological chemistry 2009;284(29):19402-11.
2009: Anita M Preininger; Michael A Funk; William M Oldham; Scott M Meier; Christopher A Johnston; Suraj Adhikary; Adam Jordan Kimple; David Siderovski; Heidi E Hamm; Tina M Iverson
Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits.
Biochemistry 2009;48(12):2630-42.
2009: Eiki Takimoto; Norimichi Koitabashi; Steven Hsu; Elizabeth A Ketner; Manling Zhang; Takahiro Nagayama; Djahida Bedja; Kathleen L Gabrielson; Robert Blanton; David Siderovski; Michael E Mendelsohn; David A Kass
Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice.
The Journal of clinical investigation 2009;119(2):408-20.
2009: Francis S Willard; Melinda D Willard; Adam Jordan Kimple; Meera Soundararajan; Emily A Oestreich; Xiaoyan Li; Nathaniel A Sowa; Randall J Kimple; Declan Doyle; Channing J Der; Mark J Zylka; William D Snider; David Siderovski
Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector.
PloS one 2009;4(3):e4884.
2008: Francis S Willard; Zhen Zheng; Juan Guo; Gregory J Digby; Adam Jordan Kimple; Jason M Conley; Christopher A Johnston; Dustin Bosch; Melinda D Willard; Val Watts; Nevin A Lambert; Stephen R Ikeda; Quansheng Du; David Siderovski
A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics.
The Journal of biological chemistry 2008;283(52):36698-710.
2008: Christopher A Johnston; Melinda D Willard; Adam Jordan Kimple; David Siderovski; Francis S Willard
A sweet cycle for Arabidopsis G-proteins: Recent discoveries and controversies in plant G-protein signal transduction.
Plant signaling & behavior 2008;3(12):1067-76.
2008: Christopher A Johnston; Katayoun Afshar; Jason T Snyder; Gregory G Tall; Pierre Gönczy; David Siderovski; Francis S Willard
Structural determinants underlying the temperature-sensitive nature of a Galpha mutant in asymmetric cell division of Caenorhabditis elegans.
The Journal of biological chemistry 2008;283(31):21550-8.
2008: Christopher A Johnston; Adam Jordan Kimple; Patrick M Giguère; David Siderovski
Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2.
Structure (London, England : 1993) 2008;16(7):1086-94.
2008: Adam Jordan Kimple; Adam Yasgar; Mark Hughes; Ajit Jadhav; Francis S Willard; Robin E Muller; Christopher P Austin; James Inglese; Gordon C Ibeanu; David Siderovski; Anton Simeonov
A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction.
Combinatorial chemistry & high throughput screening 2008;11(5):396-409.
2008: Christopher A Johnston; Francis S Willard; J Kevin Ramer; Rainer Blaesius; C Natalia Roques; David Siderovski
State-selective binding peptides for heterotrimeric G-protein subunits: novel tools for investigating G-protein signaling dynamics.
Combinatorial chemistry & high throughput screening 2008;11(5):370-81.
2008: Francis S Willard; David Siderovski
GPCR high throughput screening (part 1).
Combinatorial chemistry & high throughput screening 2008;11(5):336.
2008: Meera Soundararajan; Francis S Willard; Adam Jordan Kimple; Andrew P Turnbull; Linda J Ball; Guillaume A Schoch; Carina Gileadi; Oleg Fedorov; Elizabeth F Dowler; Victoria A Higman; Stephanie Q Hutsell; Michael Sundström; Declan Doyle; David Siderovski
Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(17):6457-62.
2008: Matthew L. Cheever; Jason T Snyder; Svetlana Gershburg; David Siderovski; T Kendall Harden; John Sondek
Crystal structure of the multifunctional Gbeta5-RGS9 complex.
Nature structural & molecular biology 2008;15(2):155-62.
2007: Christopher A Johnston; Brenda Temple; Jin-Gui Chen; Yajun Gao; Etsuko N Moriyama; Alan M Jones; David Siderovski; Francis S Willard
Comment on "A G protein coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid".
Science (New York, N.Y.) 2007;318(5852):914; author reply 914.
2007: Christopher A Johnston; J Philip Taylor; Yajun Gao; Adam Jordan Kimple; Jeffrey C Grigston; Jin-Gui Chen; David Siderovski; Alan M Jones; Francis S Willard
GTPase acceleration as the rate-limiting step in Arabidopsis G protein-coupled sugar signaling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(44):17317-22.
2007: Adam Jordan Kimple; Francis S Willard; Patrick M Giguère; Christopher A Johnston; Viorel Mocanu; David Siderovski
The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face.
Biochimica et biophysica acta 2007;1774(9):1213-20.
2007: Deanne W Sammond; Ziad M Eletr; Carrie Purbeck; Randall J Kimple; David Siderovski; Brian Kuhlman
Structure-based protocol for identifying mutations that enhance protein-protein binding affinities.
Journal of molecular biology 2007;371(5):1392-404.
2007: Christopher A Johnston; David Siderovski
Receptor-mediated activation of heterotrimeric G-proteins: current structural insights.
Molecular pharmacology 2007;72(2):219-30.
2007: Melinda D Willard; Francis S Willard; Xiaoyan Li; Steven D Cappell; William D Snider; David Siderovski
Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation.
The EMBO journal 2007;26(8):2029-40.
2007: Hao Liu; Angayarkanni Suresh; Francis S Willard; David Siderovski; Shen Lu; Naweed I Naqvi
Rgs1 regulates multiple Galpha subunits in Magnaporthe pathogenesis, asexual growth and thigmotropism.
The EMBO journal 2007;26(3):690-700.
2007: Christopher A Johnston; David Siderovski
Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(6):2001-6.
2007: Francis S Willard; Aaron B Low; Christopher R McCudden; David Siderovski
Differential G-alpha interaction capacities of the GoLoco motifs in Rap GTPase activating proteins.
Cellular signalling 2007;19(2):428-38.
2006: Christopher A Johnston; Ekaterina S Lobanova; Alexander S Shavkunov; Justin Low; J Kevin Ramer; Rainer Blaesius; Zoey Fredericks; Francis S Willard; Brian Kuhlman; Vadim Y Arshavsky; David Siderovski
Minimal determinants for binding activated G alpha from the structure of a G alpha(i1)-peptide dimer.
Biochemistry 2006;45(38):11390-400.
2006: Sascha E Dho; JoAnn Trejo; David Siderovski; C Jane McGlade
Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: Structural determinants of numb association with the cortical membrane.
Molecular biology of the cell 2006;17(9):4142-55.
2006: S Hossein Fatemi; Teri J Reutiman; Timothy D Folsom; Christopher Bell; Lisa Nos; Peter Fried; david pearce; Sushmita Singh; David Siderovski; Francis S Willard; Mitsunori Fukuda
Chronic olanzapine treatment causes differential expression of genes in frontal cortex of rats as revealed by DNA microarray technique.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(9):1888-99.
2006: Francis S Willard; Christopher R McCudden; David Siderovski
G-protein alpha subunit interaction and guanine nucleotide dissociation inhibitor activity of the dual GoLoco motif protein PCP-2 (Purkinje cell protein-2).
Cellular signalling 2006;18(8):1226-34.
2006: Balwinder Sambi; Melinda D Hains; Catherine M Waters; Michelle Connell; Francis S Willard; Adam Jordan Kimple; Susan Pyne; David Siderovski; Nigel J Pyne
The effect of RGS12 on PDGFbeta receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells.
Cellular signalling 2006;18(7):971-81.
2006: Francis S Willard; David Siderovski
Covalent immobilization of histidine-tagged proteins for surface plasmon resonance.
Analytical biochemistry 2006;353(1):147-9.
2006: Melinda D Hains; Michele R Wing; Savitri Maddileti; David Siderovski; T Kendall Harden
Galpha12/13- and rho-dependent activation of phospholipase C-epsilon by lysophosphatidic acid and thrombin receptors.
Molecular pharmacology 2006;69(6):2068-75.
2006: May M Paing; Christopher A Johnston; David Siderovski; JoAnn Trejo
Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization.
Molecular and cellular biology 2006;26(8):3231-42.
2006: Scott A Chasse; Paul Flanary; Stephen C Parnell; Nan Hao; Jiyoung Y Cha; David Siderovski; Henrik G Dohlman
Genome-scale analysis reveals Sst2 as the principal regulator of mating pheromone signaling in the yeast Saccharomyces cerevisiae.
Eukaryotic cell 2006;5(2):330-46.
2006: Francis S Willard; David Siderovski
The R6A-1 peptide binds to switch II of Galphai1 but is not a GDP-dissociation inhibitor.
Biochemical and biophysical research communications 2006;339(4):1107-12.
2005: Mihaela Zigman; Michel Cayouette; Christoforos Charalambous; Alexander Schleiffer; Oliver Hoeller; dara dunican; Christopher R McCudden; Nicole Firnberg; Ben A Barres; David Siderovski; Juergen A Knoblich
Mammalian inscuteable regulates spindle orientation and cell fate in the developing retina.
Neuron 2005;48(4):539-45.
2005: Hongyan Wang; Kian Hong Ng; Hongliang Qian; David Siderovski; William Chia; Fengwei Yu
Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins.
Nature cell biology 2005;7(11):1091-8.
2005: Christopher A Johnston; J Kevin Ramer; Rainer Blaesius; Zoey Fredericks; Val Watts; David Siderovski
A bifunctional Galphai/Galphas modulatory peptide that attenuates adenylyl cyclase activity.
FEBS letters 2005;579(25):5746-50.
2005: Katayoun Afshar; Francis S Willard; Kelly Colombo; David Siderovski; Pierre Gönczy
Cortical localization of the Galpha protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division.
Development (Cambridge, England) 2005;132(20):4449-59.
2005: Luke Martin-McCaffrey; Melinda D Hains; Grant A Pritchard; Agnieszka Pajak; Lina Dagnino; David Siderovski; Sudhir J A D'Souza
Differential expression of regulator of G-protein signaling R12 subfamily members during mouse development.
Developmental dynamics : an official publication of the American Association of Anatomists 2005;234(2):438-44.
2005: Christopher R McCudden; Francis S Willard; Randall J Kimple; Christopher A Johnston; Melinda D Hains; Miller B Jones; David Siderovski
G alpha selectivity and inhibitor function of the multiple GoLoco motif protein GPSM2/LGN.
Biochimica et biophysica acta 2005;1745(2):254-64.
2005: Christopher A Johnston; Francis S Willard; Mark R Jezyk; Zoey Fredericks; Erik T Bodor; Miller B Jones; Rainer Blaesius; Val Watts; T Kendall Harden; John Sondek; J Kevin Ramer; David Siderovski
Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange.
Structure (London, England : 1993) 2005;13(7):1069-80.
2005: Luke Martin-McCaffrey; Francis S Willard; Agnieszka Pajak; Lina Dagnino; David Siderovski; Sudhir J A D'Souza
RGS14 is a microtubule-associated protein.
Cell cycle (Georgetown, Tex.) 2005;4(7):953-60.
2005: Francis S Willard; Adam Jordan Kimple; Christopher A Johnston; David Siderovski
A direct fluorescence-based assay for RGS domain GTPase accelerating activity.
Analytical biochemistry 2005;340(2):341-51.
2005: Christina K Webb; Christopher R McCudden; Francis S Willard; Randall J Kimple; David Siderovski; Gerry S Oxford
D2 dopamine receptor activation of potassium channels is selectively decoupled by Galpha-specific GoLoco motif peptides.
Journal of neurochemistry 2005;92(6):1408-18.
2005: Christopher R McCudden; Melinda D Hains; Randall J Kimple; David Siderovski; Francis S Willard
G-protein signaling: back to the future.
Cellular and molecular life sciences : CMLS 2005;62(5):551-77.
2005: Ryan W Richman; Jesse Strock; Melinda D Hains; Nory Jun Cabanilla; King-Kei Lau; David Siderovski; María A Diversé-Pierluissi
RGS12 interacts with the SNARE-binding region of the Cav2.2 calcium channel.
The Journal of biological chemistry 2005;280(2):1521-8.
2005: Mark T Uhlik; Brenda Temple; Sompop Bencharit; Adam Jordan Kimple; David Siderovski; Gary L Johnson
Structural and evolutionary division of phosphotyrosine binding (PTB) domains.
Journal of molecular biology 2005;345(1):1-20.
2005: David Siderovski; Francis S Willard
The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits.
International journal of biological sciences 2005;1(2):51-66.
2004: Luke Martin-McCaffrey; Francis S Willard; Antonio J Oliveira-dos-Santos; David R Natale; Bryan E Snow; Randall J Kimple; Agnieszka Pajak; Andrew J Watson; Lina Dagnino; Josef M Penninger; David Siderovski; Sudhir J A D'Souza
RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote.
Developmental cell 2004;7(5):763-9.
2004: Katayoun Afshar; Francis S Willard; Kelly Colombo; Christopher A Johnston; Christopher R McCudden; David Siderovski; Pierre Gönczy
RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos.
Cell 2004;119(2):219-30.
2004: Miller B Jones; David Siderovski; Shelley Hooks Pence
The G betagamma dimer as a novel source of selectivity in G-protein signaling: GGL-ing at convention.
Molecular interventions 2004;4(4):200-14.
2004: Randall J Kimple; Francis S Willard; Melinda D Hains; Miller B Jones; Gift K Nweke; David Siderovski
Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif.
The Biochemical journal 2004;378(Pt 3):801-8.
2004: Randall J Kimple; Francis S Willard; David Siderovski
Purification and in vitro functional analyses of RGS12 and RGS14 GoLoco motif peptides.
Methods in enzymology 2004;390():416-36.
2004: Luke Martin-McCaffrey; Francis S Willard; Agnieszka Pajak; Lina Dagnino; David Siderovski; Sudhir J A D'Souza
Analysis of interactions between regulator of G-protein signaling-14 and microtubules.
Methods in enzymology 2004;390():240-58.
2004: Francis S Willard; David Siderovski
Purification and in vitro functional analysis of the Arabidopsis thaliana regulator of G-protein signaling-1.
Methods in enzymology 2004;389():320-38.
2004: Melinda D Hains; David Siderovski; T Kendall Harden
Application of RGS box proteins to evaluate G-protein selectivity in receptor-promoted signaling.
Methods in enzymology 2004;389():71-88.
2004: Francis S Willard; Randall J Kimple; Adam Jordan Kimple; Christopher A Johnston; David Siderovski
Fluorescence-based assays for RGS box function.
Methods in enzymology 2004;389():56-71.
2004: Francis S Willard; Randall J Kimple; David Siderovski
Return of the GDI: the GoLoco motif in cell division.
Annual review of biochemistry 2004;73():925-51.
2003: K Mary Tang; Guang-rong Wang; Ping Lu; Richard H Karas; Mark Aronovitz; Scott P Heximer; Kevin M Kaltenbronn; Kendall J Blumer; David Siderovski; Yan Zhu; Michael Mendelsohn; Mary Tang; Guang Wang
Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure.
Nature medicine 2003;9(12):1506-12.
2003: Jin-Gui Chen; Francis S Willard; Jirong Huang; Jiansheng Liang; Scott A Chasse; Alan M Jones; David Siderovski
A seven-transmembrane RGS protein that modulates plant cell proliferation.
Science (New York, N.Y.) 2003;301(5640):1728-31.
2003: Kelly Colombo; Stephan W Grill; Randall J Kimple; Francis S Willard; David Siderovski; Pierre Gönczy
Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos.
Science (New York, N.Y.) 2003;300(5627):1957-61.
2003: Rafael J Rojas; Randall J Kimple; Kent L Rossman; David Siderovski; John Sondek
Established and emerging fluorescence-based assays for G-protein function: Ras-superfamily GTPases.
Combinatorial chemistry & high throughput screening 2003;6(4):409-18.
2003: Randall J Kimple; Miller B Jones; Adam Shutes; Benjamin R Yerxa; David Siderovski; Francis S Willard
Established and emerging fluorescence-based assays for G-protein function: heterotrimeric G-protein alpha subunits and regulator of G-protein signaling (RGS) proteins.
Combinatorial chemistry & high throughput screening 2003;6(4):399-407.
2003: Wendy M Pruitt; Antoine E Karnoub; A Corinne Rakauskas; Michel Guipponi; Stylianos E Antonarakis; Alexei Kurakin; Brian Kay; John Sondek; David Siderovski; Channing J Der
Role of the pleckstrin homology domain in intersectin-L Dbl homology domain activation of Cdc42 and signaling.
Biochimica et biophysica acta 2003;1640(1):61-8.
2002: John M Lambert; Que T Lambert; Gary W Reuther; Angeliki Malliri; David Siderovski; John Sondek; John G Collard; Channing J Der
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism.
Nature cell biology 2002;4(8):621-5.
2002: Qin Wang; Min Liu; Bashar Mullah; David Siderovski; Richard Neubig
Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells.
The Journal of biological chemistry 2002;277(28):24949-58.
2002: Michelle A Booden; David Siderovski; Channing J Der
Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA.
Molecular and cellular biology 2002;22(12):4053-61.
2002: Jason T Snyder; David K Worthylake; Kent L Rossman; Laurie Betts; Wendy M Pruitt; David Siderovski; Channing J Der; John Sondek
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nature structural biology 2002;9(6):468-75.
2002: Randall J Kimple; Michelle Kimple; Laurie Betts; John Sondek; David Siderovski
Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits.
Nature 2002;416(6883):878-81.
2002: Randall J Kimple; Francis S Willard; David Siderovski
The GoLoco motif: heralding a new tango between G protein signaling and cell division.
Molecular interventions 2002;2(2):88-100.
2002: Kent L Rossman; David K Worthylake; Jason T Snyder; David Siderovski; Sharon L Campbell; John Sondek
A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
The EMBO journal 2002;21(6):1315-26.
2002: Richard Neubig; David Siderovski
Regulators of G-protein signalling as new central nervous system drug targets.
Nature reviews. Drug discovery 2002;1(3):187-97.
2002: Bryan E Snow; Greg M Brothers; David Siderovski
Molecular cloning of regulators of G-protein signaling family members and characterization of binding specificity of RGS12 PDZ domain.
Methods in enzymology 2002;344():740-61.
2002: David Siderovski; Bryan E Snow; Stephen Chung; Greg M Brothers; John Sondek; Laurie Betts
Assays of complex formation between RGS protein G gamma subunit-like domains and G beta subunits.
Methods in enzymology 2002;344():702-23.
2001: Bonita L Blake; Michele R Wing; J Y Zhou; Qiubo Lei; J R Hillmann; CI Behe; R A Morris; T Kendall Harden; Douglas A Bayliss; R J Miller; David Siderovski
G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13).
The Journal of biological chemistry 2001;276(52):49267-74.
2001: Michele R Wing; Dayle Houston; G G Kelley; Channing J Der; David Siderovski; T Kendall Harden
Activation of phospholipase C-epsilon by heterotrimeric G protein betagamma-subunits.
The Journal of biological chemistry 2001;276(51):48257-61.
2001: Jason T Snyder; Kent L Rossman; Mark A Baumeister; Wendy M Pruitt; David Siderovski; Channing J Der; Mark A Lemmon; John Sondek
Quantitative analysis of the effect of phosphoinositide interactions on the function of Dbl family proteins.
The Journal of biological chemistry 2001;276(49):45868-75.
2001: Michelle Kimple; David Siderovski; John Sondek
Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpA.
The EMBO journal 2001;20(16):4414-22.
2001: Randall J Kimple; Luc De Vries; H Tronchère; CI Behe; R A Morris; M Gist Farquhar; David Siderovski
RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity.
The Journal of biological chemistry 2001;276(31):29275-81.
2001: Daniel Evanko; Manimekalai M Thiyagarajan; David Siderovski; Philip B Wedegaertner
Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq.
The Journal of biological chemistry 2001;276(26):23945-53.
2001: John Sondek; David Siderovski
Ggamma-like (GGL) domains: new frontiers in G-protein signaling and beta-propeller scaffolding.
Biochemical pharmacology 2001;61(11):1329-37.
2000: Luc De Vries; Thierry Fischer; H Tronchère; Greg M Brothers; B Strockbine; David Siderovski; Marilyn G Farquhar
Activator of G protein signaling 3 is a guanine dissociation inhibitor for Galpha i subunits.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14364-9.
2000: M L Schiff; David Siderovski; Joseph Jordan; Greg M Brothers; B Snow; Luc De Vries; Daniel F Ortiz; María A Diversé-Pierluissi
Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel.
Nature 2000;408(6813):723-7.
2000: Yie Liu; Bryan E Snow; M Prakash Hande; D Yeung; Natalie Erdmann; Andrew Wakeham; Annick Itie; David Siderovski; PM Lansdorp; Murray O Robinson; Lea Harrington
The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo.
Current biology : CB 2000;10(22):1459-62.
2000: Yie Liu; Bryan E Snow; M Prakash Hande; G Baerlocher; Valerie A Kickhoefer; D Yeung; Andrew Wakeham; Annick Itie; David Siderovski; PM Lansdorp; Murray O Robinson; Lea Harrington
Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo.
Molecular and cellular biology 2000;20(21):8178-84.
2000: Antonio J Oliveira-dos-Santos; Goichi Matsumoto; Bryan E Snow; D Bai; Frank P Houston; Ian Q Whishaw; Sanjeev Mariathasan; T Sasaki; Andrew Wakeham; Pamela S Ohashi; John C Roder; Carol A Barnes; David Siderovski; Josef M Penninger
Regulation of T cell activation, anxiety, and male aggression by RGS2.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12272-7.
2000: J Y Zhou; David Siderovski; Richard J Miller
Selective regulation of N-type Ca channels by different combinations of G-protein beta/gamma subunits and RGS proteins.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(19):7143-8.
2000: D A Bressant; Annette M Payne; B E Snow; G Antiño; S Qasim Mehdi; A C Bird; David Siderovski; S S Bhattacharya
Importance of the autosomal recessive retinitis pigmentosa locus on 1q31-q32.1 (RP12) and mutation analysis of the candidate gene RGS16 (RGS-r)
Journal of medical genetics 2000;37(5):384-7.
1999: David Siderovski; María A Diversé-Pierluissi; Luc De Vries
The GoLoco motif: a Galphai/o binding motif and potential guanine-nucleotide exchange factor.
Trends in biochemical sciences 1999;24(9):340-1.
1999: Bryan E Snow; Laurie Betts; J Mangion; John Sondek; David Siderovski
Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6489-94.
1999: Santos A Susin; Hans Lorenzo; Naoufal Zamzami; I Marzo; B E Snow; Greg M Brothers; J Mangion; Etienne Jacotot; P Costantini; M Loeffler; Nathanael Larochette; D R Goodlett; R Aebersold; David Siderovski; Josef M Penninger; Guido Kroemer
Molecular characterization of mitochondrial apoptosis-inducing factor.
Nature 1999;397(6718):441-6.
1999: David Siderovski; B Strockbine; CI Behe
Whither goest the RGS proteins?
Critical reviews in biochemistry and molecular biology 1999;34(4):215-51.
1998: Bryan E Snow; Andrejs M Krumins; Greg M Brothers; S F Lee; Mark A Wall; Stephen Chung; J Mangion; S Arya; Alfred G Gilman; David Siderovski
A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):13307-12.
1998: Vuk Stambolic; Akira Suzuki; José Luis de la Pompa; Greg M Brothers; Christine Mirtsos; Takehiko Sasaki; Jürgen Ruland; Josef M Penninger; David Siderovski; Tak W Mak
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.
Cell 1998;95(1):29-39.
1998: Tatsuya Ingi; Andrejs M Krumins; P Chidiac; Greg M Brothers; S Chung; B E Snow; Carol A Barnes; Anthony A Lanahan; David Siderovski; Elliott M Ross; Alfred G Gilman; Paul F Worley
Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(18):7178-88.
1998: Bryan E Snow; R A Hall; Andrejs M Krumins; Greg M Brothers; Denis Bouchard; C A Brothers; Stephen Chung; J Mangion; Alfred G Gilman; R J Lefkowitz; David Siderovski
GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.
The Journal of biological chemistry 1998;273(28):17749-55.
1998: Adelinda A Yee; P Yin; David Siderovski; T W Mak; D W Litchfield; Cheryl H Arrowsmith
Cooperative interaction between the DNA-binding domains of PU.1 and IRF4.
Journal of molecular biology 1998;279(5):1075-83.
1998: Bryan E Snow; L Antonio; S Suggs; David Siderovski
Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene.
Gene 1998;206(2):247-53.
1997: Susan McCracken; Nova Fong; Emanuel Rosonina; Krassimir Yankulov; G Brothers; David Siderovski; A Hessel; S Foster; Stewart Shuman; David L Bentley
5'-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II.
Genes & development 1997;11(24):3306-18.
1997: Bryan E Snow; L Antonio; S Suggs; H B Gutstein; David Siderovski
Molecular cloning and expression analysis of rat Rgs12 and Rgs14.
Biochemical and biophysical research communications 1997;233(3):770-7.
1996: A Grossman; Hans-Willi Mittrücker; J Nicholl; A Suzuki; S Chung; L Antonio; S Suggs; G R Sutherland; David Siderovski; Tak W Mak
Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25.
Genomics 1996;37(2):229-33.
1996: HK Wu; Hong-Qiang Heng; David Siderovski; Wei-Feng Dong; Y Okuno; XM Shi; Lap-Chee Tsui; Mark D Minden
Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1.
Oncogene 1996;12(6):1205-12.
1996: David Siderovski; A Hessel; S Chung; T W Mak; M Tyers
A new family of regulators of G-protein-coupled receptors?
Current biology : CB 1996;6(2):211-2.
1995: N A McMillan; R F Chun; David Siderovski; J Galabru; W M Toone; C E Samuel; T W Mak; A G Hovanessian; K T Jeang; Bryan R G Williams
HIV-1 Tat directly interacts with the interferon-induced, double-stranded RNA-dependent kinase, PKR.
Virology 1995;213(2):413-24.
1995: HK Wu; Hong-Qiang Heng; XM Shi; Donald R Forsdyke; Lap-Chee Tsui; Tak W Mak; Mark D Minden; David Siderovski
Differential expression of a basic helix-loop-helix phosphoprotein gene, G0S8, in acute leukemia and localization to human chromosome 1q31.
Leukemia 1995;9(8):1291-8.
1995: Takeshi Matsuyama; A Grossman; Hans-Willi Mittrücker; David Siderovski; F Kiefer; T Kawakami; Christopher D Richardson; T Taniguchi; S K Yoshinaga; Tak W Mak
Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE).
Nucleic acids research 1995;23(12):2127-36.
1994: David Siderovski; SP Heximer; Donald R Forsdyke
A human gene encoding a putative basic helix-loop-helix phosphoprotein whose mRNA increases rapidly in cycloheximide-treated blood mononuclear cells.
DNA and cell biology 1994;13(2):125-47.
1993: David Siderovski; T W Mak
RAMHA: a PC-based Monte-Carlo simulation of random saturation mutagenesis.
Computers in biology and medicine 1993;23(6):463-74.
1992: David Siderovski; T Matsuyama; E Frigerio; S Chui; X Min; H Erfle; M Sumner-Smith; R W Barnett; Tak W Mak
Random mutagenesis of the human immunodeficiency virus type-1 trans-activator of transcription (HIV-1 Tat).
Nucleic acids research 1992;20(20):5311-20.
1992: T J Molina; Kenji Kishihara; David Siderovski; W van Ewijk; A Narendran; E Timms; Andrew Wakeham; Christopher J Paige; K U Hartmann; André Veillette
Profound block in thymocyte development in mice lacking p56lck.
Nature 1992;357(6374):161-4.
1990: David Siderovski; S Blum; R E Forsdyke; Donald R Forsdyke
A set of human putative lymphocyte G0/G1 switch genes includes genes homologous to rodent cytokine and zinc finger protein-encoding genes.
DNA and cell biology 1990;9(8):579-87.