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Toni Cathomen

Research Profile

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DNA Breaks, Double-Stranded

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Publications

TOP 3
Claudio Mussolino; Toni Cathomen
RNA guides genome engineering.
Maarten Holkers; Josephine M Janssen; Jin Liu; Ignazio Maggio; Francesca Miselli; Claudio Mussolino; Alessandra Recchia; Toni Cathomen; Manuel A F V Gonçalves
Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells.
Shamim H Rahman; Sylwia Bobis-Wozowicz; Debanjana Chatterjee; Katharina Gellhaus; Regine Heilbronn; Roland Jacobs; Kaweh Pars; Toni Cathomen
The nontoxic cell cycle modulator indirubin augments transduction of adeno-associated viral vectors and zinc-finger nuclease-mediated gene targeting.

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All Publications

2013: Claudio Mussolino; Toni Cathomen
RNA guides genome engineering.
Nature biotechnology 2013;31(3):208-9.
2013: Maarten Holkers; Josephine M Janssen; Jin Liu; Ignazio Maggio; Francesca Miselli; Claudio Mussolino; Alessandra Recchia; Toni Cathomen; Manuel A F V Gonçalves
Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells.
Nucleic acids research 2013;41(5):e63.
2013: Shamim H Rahman; Sylwia Bobis-Wozowicz; Debanjana Chatterjee; Katharina Gellhaus; Regine Heilbronn; Roland Jacobs; Kaweh Pars; Toni Cathomen
The nontoxic cell cycle modulator indirubin augments transduction of adeno-associated viral vectors and zinc-finger nuclease-mediated gene targeting.
Human gene therapy 2013;24(1):67-77.
2013: Qinggong Yuan; Arndt Vogel; Asha Balakrishnan; Tobias Cantz; Toni Cathomen; Jutta Lamle; Komal Loya; Michael P Manns; Selina Möbus; Michael Ott; Bhavna Rani; Amar Deep Sharma
MicroRNA-221 overexpression accelerates hepatocyte proliferation during liver regeneration.
Hepatology (Baltimore, Md.) 2013;57(1):299-310.
2012: Katrin Voigt; Zsuzsanna Izsvák; Csaba Miskey; Toni Cathomen; Wei Chen; Andreas Gogol-Döring; Zoltán Ivics
Retargeting sleeping beauty transposon insertions by engineered zinc finger DNA-binding domains.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(10):1852-62.
2012: Claudio Mussolino; Toni Cathomen
TALE nucleases: tailored genome engineering made easy.
Current opinion in biotechnology 2012;23(5):644-50.
2012: Ismahen Ammar; Toni Cathomen; Wei Chen; Andreas Gogol-Döring; Zsuzsanna Izsvák; Csaba Miskey; Zoltán Ivics
Retargeting transposon insertions by the adeno-associated virus Rep protein.
Nucleic acids research 2012;40(14):6693-712.
2012: Cherie L Ramirez; Andrew M Scharenberg; Anton P McCaffrey; Claudio Mussolino; Toni Cathomen; Michael T Certo; Thomas J Cradick; Mathew J Goodwin; J Keith Joung
Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects.
Nucleic acids research 2012;40(12):5560-8.
2012: Thorsten Höher; Kafaitullah Khan; Toni Cathomen; Lee Wallace; Julia Reichelt
Highly efficient zinc-finger nuclease-mediated disruption of an eGFP transgene in keratinocyte stem cells without impairment of stem cell properties.
Stem cell reviews 2012;8(2):426-34.
2012: Martin Alex; Toni Cathomen; Mario Mietzsch; Heiko Slanina; Stefan Weger; Regine Heilbronn
DNA-binding activity of adeno-associated virus Rep is required for inverted terminal repeat-dependent complex formation with herpes simplex virus ICP8.
Journal of virology 2012;86(5):2859-63.
2012: Benno Schierling; Wolfgang Wende; Toni Cathomen; Nadine Dannemann; Lilia Gabsalilow; Alfred Pingoud
A novel zinc-finger nuclease platform with a sequence-specific cleavage module.
Nucleic acids research 2012;40(6):2623-38.
2012: Eva-Maria Händel; Regine Heilbronn; Kafaitullah Khan; Robert M Kotin; Felix Müller-Lerch; Christien Bednarski; Tatjana I Cornu; Katharina Gellhaus; Toni Cathomen
Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors.
Human gene therapy 2012;23(3):321-9.
2012: Anne-Kathrin Dreyer; Toni Cathomen
Zinc-finger nucleases-based genome engineering to generate isogenic human cell lines.
Methods in molecular biology (Clifton, N.J.) 2012;813():145-56.
2011: Claudio Mussolino; Nadine Dannemann; Thomas Lahaye; Fabienne Lütge; Robert Morbitzer; Toni Cathomen
A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity.
Nucleic acids research 2011;39(21):9283-93.
2011: Claudio Mussolino; Toni Cathomen
On target? Tracing zinc-finger-nuclease specificity.
Nature methods 2011;8(9):725-6.
2011: Shamim H Rahman; J Keith Joung; Morgan L Maeder; Toni Cathomen
Zinc-finger nucleases for somatic gene therapy: the next frontier.
Human gene therapy 2011;22(8):925-33.
2011: Yuka Shimizu; Cem Şöllü; Artem Zykovich; Alice Adriaenssens; Toni Cathomen; Joshua F Meckler; David J Segal
Adding fingers to an engineered zinc finger nuclease can reduce activity.
Biochemistry 2011;50(22):5033-41.
2011: Amar Deep Sharma; Nidhi Narain; Eva-Maria Händel; Marcus Iken; Nishant Singhal; Toni Cathomen; Michael P Manns; Hans R Schöler; Michael Ott; Tobias Cantz
MicroRNA-221 regulates FAS-induced fulminant liver failure.
Hepatology (Baltimore, Md.) 2011;53(5):1651-61.
2011: Sylwia Bobis-Wozowicz; Anna Osiak; Shamim H Rahman; Toni Cathomen
Targeted genome editing in pluripotent stem cells using zinc-finger nucleases.
Methods (San Diego, Calif.) 2011;53(4):339-46.
2011: Eva-Maria Händel; Toni Cathomen
Zinc-finger nuclease based genome surgery: it's all about specificity.
Current gene therapy 2011;11(1):28-37.
2010: Madlen Rother; Stefanie Krohn; Gabriela Kania; Davy Vanhoutte; Andreas Eisenreich; Xiaomin Wang; Dirk Westermann; Kostas Savvatis; Nadine Dannemann; Carsten Skurk; Denise Hilfiker-Kleiner; Toni Cathomen; Henry Fechner; Ursula Rauch; Heinz-Peter Schultheiss; Stephane Heymans; Urs Eriksson; Carmen Scheibenbogen; Wolfgang Poller
Matricellular signaling molecule CCN1 attenuates experimental autoimmune myocarditis by acting as a novel immune cell migration modulator.
Circulation 2010;122(25):2688-98.
2010: Axel Schambach; Tobias Cantz; Christopher Baum; Toni Cathomen
Generation and genetic modification of induced pluripotent stem cells.
Expert opinion on biological therapy 2010;10(7):1089-103.
2010: Katharina Gellhaus; Tatjana I Cornu; Regine Heilbronn; Toni Cathomen
Fate of recombinant adeno-associated viral vector genomes during DNA double-strand break-induced gene targeting in human cells.
Human gene therapy 2010;21(5):543-53.
2010: Sarah Radecke; Frank Radecke; Toni Cathomen; Klaus Schwarz
Zinc-finger nuclease-induced gene repair with oligodeoxynucleotides: wanted and unwanted target locus modifications.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(4):743-53.
2010: Tatjana I Cornu; Toni Cathomen
Quantification of zinc finger nuclease-associated toxicity.
Methods in molecular biology (Clifton, N.J.) 2010;649():237-45.
2010: Toni Cathomen; Cem Söllü
In vitro assessment of zinc finger nuclease activity.
Methods in molecular biology (Clifton, N.J.) 2010;649():227-35.
2010: Daniela Hüser; Andreas Gogol-Döring; Timo Lutter; Stefan Weger; Kerstin Winter; Eva Hammer; Toni Cathomen; Knut Reinert; Regine Heilbronn
Integration preferences of wildtype AAV-2 for consensus rep-binding sites at numerous loci in the human genome.
PLoS pathogens 2010;6(7):e1000985.
2009: Vladimir Ermolayev; Toni Cathomen; Julia Merk; Mike Friedrich; Wolfgang Härtig; Gregory S Harms; Michael A Klein; Eckhard Flechsig
Impaired axonal transport in motor neurons correlates with clinical prion disease.
PLoS pathogens 2009;5(8):e1000558.
2009: Vladimir Ermolayev; Mike Friedrich; Revaz Nozadze; Toni Cathomen; Michael A Klein; Gregory S Harms; Eckhard Flechsig
Ultramicroscopy reveals axonal transport impairments in cortical motor neurons at prion disease.
Biophysical journal 2009;96(8):3390-8.
2009: Eva-Maria Händel; Stephen Alwin; Toni Cathomen
Expanding or restricting the target site repertoire of zinc-finger nucleases: the inter-domain linker as a major determinant of target site selectivity.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(1):104-11.
2008: Morgan L Maeder; Stacey Thibodeau-Beganny; Anna Osiak; David A Wright; Reshma M Anthony; Magdalena Eichtinger; Tao Jiang; Jonathan E Foley; Ronnie J Winfrey; Jeffrey A Townsend; Erica Unger-Wallace; Jeffry D Sander; Felix Müller-Lerch; Fengli Fu; Joseph Pearlberg; Carl Göbel; Justin P Dassie; Shondra M Pruett-Miller; Matthew H Porteus; Dennis C Sgroi; A John Iafrate; Drena Dobbs; Paul B McCray; Toni Cathomen; Daniel F Voytas; J Keith Joung
Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification.
Molecular cell 2008;31(2):294-301.
2008: Toni Cathomen; J Keith Joung
Zinc-finger nucleases: the next generation emerges.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(7):1200-7.
2008: Jens Bohne; Toni Cathomen
Genotoxicity in gene therapy: an account of vector integration and designer nucleases.
Current opinion in molecular therapeutics 2008;10(3):214-23.
2008: Cherie L Ramirez; Jonathan E Foley; David A Wright; Felix Müller-Lerch; Shamim H Rahman; Tatjana I Cornu; Ronnie J Winfrey; Jeffry D Sander; Fengli Fu; Jeffrey A Townsend; Toni Cathomen; Daniel F Voytas; J Keith Joung
Unexpected failure rates for modular assembly of engineered zinc fingers.
Nature methods 2008;5(5):374-5.
2008: Tatjana I Cornu; Stacey Thibodeau-Beganny; Eva Guhl; Stephen Alwin; Magdalena Eichtinger; J Keith Joung; J K Joung; Toni Cathomen
DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(2):352-8.
2008: Toni Cathomen; David J Segal; Vincent Brondani; Felix Müller-Lerch
Generation and functional analysis of zinc finger nucleases.
Methods in molecular biology (Clifton, N.J.) 2008;434():277-90.
2007: Tatjana I Cornu; Toni Cathomen
Targeted genome modifications using integrase-deficient lentiviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(12):2107-13.
2007: Michal Szczepek; Vincent Brondani; Janine Büchel; Luis Serrano; David J Segal; Toni Cathomen
Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases.
Nature biotechnology 2007;25(7):786-93.
2006: Frank Radecke; Ingrid Peter; Sarah Radecke; Katharina Gellhaus; Klaus Schwarz; Toni Cathomen
Targeted chromosomal gene modification in human cells by single-stranded oligodeoxynucleotides in the presence of a DNA double-strand break.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(6):798-808.
2005: Toni Cathomen; Matthew D Weitzman
Gene repair: pointing the finger at genetic disease.
Gene therapy 2005;12(19):1415-6.
2005: Stephen Alwin; Maja B Gere; Eva Guhl; Karin Effertz; Carlos F Barbas; David J Segal; Matthew D Weitzman; Toni Cathomen
Custom zinc-finger nucleases for use in human cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(4):610-7.
2004: Toni Cathomen
AAV vectors for gene correction.
Current opinion in molecular therapeutics 2004;6(4):360-6.
2003: Matthew H Porteus; Toni Cathomen; Matthew D Weitzman; David Baltimore
Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks.
Molecular and cellular biology 2003;23(10):3558-65.
2003: Matthew D Weitzman; Samuel M Young; Toni Cathomen; R Jude Samulski
Targeted integration by adeno-associated virus.
Methods in molecular medicine 2003;76():201-19.
2001: Toni Cathomen; Travis H Stracker; L B Gilbert; Matthew D Weitzman
A genetic screen identifies a cellular regulator of adeno-associated virus.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):14991-6.
2000: Toni Cathomen; Matthew D Weitzman
A functional complex of adenovirus proteins E1B-55kDa and E4orf6 is necessary to modulate the expression level of p53 but not its transcriptional activity.
Journal of virology 2000;74(23):11407-12.
2000: Toni Cathomen; D Collete; Matthew D Weitzman
A chimeric protein containing the N terminus of the adeno-associated virus Rep protein recognizes its target site in an in vivo assay.
Journal of virology 2000;74(5):2372-82.
1999: Mirta S Grifman; N N Chen; G P Gao; Toni Cathomen; J M Wilson; Matthew D Weitzman
Overexpression of cyclin A inhibits augmentation of recombinant adeno-associated virus transduction by the adenovirus E4orf6 protein.
Journal of virology 1999;73(12):10010-9.