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Byron Caughey

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Christina D Orrù; Sarah Vascellari; Jason M Wilham; Andrew G Hughson; Byron Caughey
New generation QuIC assays for prion seeding activity.
Christina D Orrù; Brent Race; Gregory J Raymond; Andrew G Hughson; Byron Caughey
Time course of prion seeding activity in cerebrospinal fluid of scrapie-infected hamsters after intratongue and intracerebral inoculations.
Rie Hasebe; Motohiro Horiuchi; Gregory J Raymond; Byron Caughey
Reaction of complement factors varies with prion strains in vitro and in vivo.

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All Publications

2012: Christina D Orrù; Sarah Vascellari; Jason M Wilham; Andrew G Hughson; Byron Caughey
New generation QuIC assays for prion seeding activity.
Prion 2012;6(2):147-52.
2012: Christina D Orrù; Brent Race; Gregory J Raymond; Andrew G Hughson; Byron Caughey
Time course of prion seeding activity in cerebrospinal fluid of scrapie-infected hamsters after intratongue and intracerebral inoculations.
Journal of clinical microbiology 2012;50(4):1464-6.
2012: Rie Hasebe; Motohiro Horiuchi; Gregory J Raymond; Byron Caughey
Reaction of complement factors varies with prion strains in vitro and in vivo.
Virology 2012;423(2):205-13.
2012: Sarah Vascellari; Jason M Wilham; Gerald S Baron; Rona Barron; Andrew G Hughson; Declan King; Christina D Orrù; Alessandra Pani; Brent Race; Byron Caughey
Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC.
PloS one 2012;7(11):e48969.
2011: Gerald S Baron; Andrew G Hughson; Gregory J Raymond; Danielle K Offerdahl; Kelly A Barton; Lynne D Raymond; David W Dorward; Byron Caughey
Effect of glycans and the glycophosphatidylinositol anchor on strain dependent conformations of scrapie prion protein: improved purifications and infrared spectra.
Biochemistry 2011;50(21):4479-90.
2011: Kelly A Barton; Byron Caughey
Is PrP the road to ruin?
The EMBO journal 2011;30(10):1882-4.
2011: Vytautas Smirnovas; Gerald S Baron; Danielle K Offerdahl; Gregory J Raymond; Byron Caughey; Witold K Surewicz
Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange.
Nature structural & molecular biology 2011;18(4):504-6.
2011: Christina D Orrú; Byron Caughey
Prion seeded conversion and amplification assays.
Topics in current chemistry 2011;305():121-33.
2011: Christina D Orrú; Jason M Wilham; Lynne D Raymond; Franziska Kuhn; Björn Schroeder; Alex J Raeber; Byron Caughey
Prion disease blood test using immunoprecipitation and improved quaking-induced conversion.
mBio 2011;2(3):e00078-11.
2010: Lara M Taubner; Ewa A Bienkiewicz; Valérie Copié; Byron Caughey
Structure of the flexible amino-terminal domain of prion protein bound to a sulfated glycan.
Journal of molecular biology 2010;395(3):475-90.
2010: Jason M Wilham; Christina D Orrú; RA Bessen; Ryuichiro Atarashi; Kazunori Sano; Brent Race; Kimberly Meade-White; Lara M Taubner; Andrew Timmes; Byron Caughey
Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays.
PLoS pathogens 2010;6(12):e1001217.
2009: Valerie L Sim; Byron Caughey
Ultrastructures and strain comparison of under-glycosylated scrapie prion fibrils.
Neurobiology of aging 2009;30(12):2031-42.
2009: Christina D Orrú; Jason M Wilham; Andrew G Hughson; Lynne D Raymond; Kristin L McNally; Alex Bossers; Ciriaco Ligios; Byron Caughey
Human variant Creutzfeldt-Jakob disease and sheep scrapie PrP(res) detection using seeded conversion of recombinant prion protein.
Protein engineering, design & selection : PEDS 2009;22(8):515-21.
2009: Valerie L Sim; Byron Caughey
Recent advances in prion chemotherapeutics.
Infectious disorders drug targets 2009;9(1):81-91.
2009: Byron Caughey; Gerald S Baron; Bruce Chesebro; Martin Jeffrey
Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions.
Annual review of biochemistry 2009;78():177-204.
2008: Byron Caughey; Gerald S Baron
Are cheetahs on the run from prion-like amyloidosis?
Proceedings of the National Academy of Sciences of the United States of America 2008;105(20):7113-4.
2008: Ryuichiro Atarashi; Jason M Wilham; Leah Christensen; Andrew G Hughson; Roger A Moore; Lisa M Johnson; Henry A Onwubiko; Suzette A Priola; Byron Caughey
Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking.
Nature methods 2008;5(3):211-2.
2007: Kil S Lee; Lynne D Raymond; Brianna Schoen; Gregory J Raymond; Lauren Kett; Roger A Moore; Lisa M Johnson; Lara Taubner; Jonathan O Speare; Henry A Onwubiko; Gerald S Baron; Winslow S Caughey; Byron Caughey
Hemin interactions and alterations of the subcellular localization of prion protein.
The Journal of biological chemistry 2007;282(50):36525-33.
2007: Winslow S Caughey; Suzette A Priola; David Kocisko; Lynne D Raymond; Anne Ward; Byron Caughey
Cyclic tetrapyrrole sulfonation, metals, and oligomerization in antiprion activity.
Antimicrobial agents and chemotherapy 2007;51(11):3887-94.
2007: Ryuichiro Atarashi; Roger A Moore; Valerie L Sim; Andrew G Hughson; David W Dorward; Henry A Onwubiko; Suzette A Priola; Byron Caughey
Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein.
Nature methods 2007;4(8):645-50.
2007: Kil Sun Lee; Byron Caughey
A simplified recipe for prions.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(23):9551-2.
2007: Gregory J Raymond; Lynne D Raymond; Kimberly Meade-White; Andrew G Hughson; Cynthia Favara; Donald Gardner; Elizabeth S Williams; Michael W Miller; Richard E Race; Byron Caughey
Transmission and adaptation of chronic wasting disease to hamsters and transgenic mice: evidence for strains.
Journal of virology 2007;81(8):4305-14.
2007: David Kocisko; Nadine Bertholet; Roger A Moore; Byron Caughey; Andrew Vaillant
Identification of prion inhibitors by a fluorescence-polarization-based competitive binding assay.
Analytical biochemistry 2007;363(1):154-6.
2006: Mari L DeMarco; Jay Silveira; Byron Caughey; Valerie Daggett
Structural properties of prion protein protofibrils and fibrils: an experimental assessment of atomic models.
Biochemistry 2006;45(51):15573-82.
2006: Abdessamad Tahiri-Alaoui; Valerie L Sim; Byron Caughey; William James
Molecular heterosis of prion protein beta-oligomers. A potential mechanism of human resistance to disease.
The Journal of biological chemistry 2006;281(45):34171-8.
2006: Byron Caughey; Gerald S Baron
Prions and their partners in crime.
Nature 2006;443(7113):803-10.
2006: David Kocisko; Byron Caughey; John D Morrey; Richard E Race
Enhanced antiscrapie effect using combination drug treatment.
Antimicrobial agents and chemotherapy 2006;50(10):3447-9.
2006: Byron Caughey; Winslow S Caughey; David Kocisko; Kil S Lee; Jay R Silveira; John D Morrey
Prions and transmissible spongiform encephalopathy (TSE) chemotherapeutics: A common mechanism for anti-TSE compounds?
Accounts of chemical research 2006;39(9):646-53.
2006: Ryuichiro Atarashi; Valerie L Sim; Noriyuki Nishida; Byron Caughey; Shigeru Katamine
Prion strain-dependent differences in conversion of mutant prion proteins in cell culture.
Journal of virology 2006;80(16):7854-62.
2006: David Kocisko; Andrew Vaillant; Kil Sun Lee; Kevin M Arnold; Nadine Bertholet; Richard E Race; Emily A Olsen; Jean-Marc Juteau; Byron Caughey
Potent antiscrapie activities of degenerate phosphorothioate oligonucleotides.
Antimicrobial agents and chemotherapy 2006;50(3):1034-44.
2006: Gerald S Baron; Ana C Magalhães; Marco Prado; Byron Caughey
Mouse-adapted scrapie infection of SN56 cells: greater efficiency with microsome-associated versus purified PrP-res.
Journal of virology 2006;80(5):2106-17.
2006: David Kocisko; Winslow S Caughey; Richard E Race; Grant Roper; Byron Caughey; John D Morrey
A porphyrin increases survival time of mice after intracerebral prion infection.
Antimicrobial agents and chemotherapy 2006;50(2):759-61.
2006: David Kocisko; Byron Caughey
Searching for anti-prion compounds: cell-based high-throughput in vitro assays and animal testing strategies.
Methods in enzymology 2006;412():223-34.
2006: Jay R Silveira; Andrew G Hughson; Byron Caughey
Fractionation of prion protein aggregates by asymmetrical flow field-flow fractionation.
Methods in enzymology 2006;412():21-33.
2006: David Kocisko; Byron Caughey
Mefloquine, an antimalaria drug with antiprion activity in vitro, lacks activity in vivo.
Journal of virology 2006;80(2):1044-6.
2006: Gregory J Raymond; Emily A Olsen; Kil Sun Lee; Lynne D Raymond; P Kruger Bryant; Gerald S Baron; Winslow S Caughey; David Kocisko; Linda E McHolland; Cynthia Favara; Jan P M Langeveld; Fred G van Zijderveld; Richard T Mayer; Michael W Miller; Elizabeth S Williams; Byron Caughey
Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting disease.
Journal of virology 2006;80(2):596-604.
2005: David Kocisko; Abbi L Engel; Kristin Harbuck; Kevin M Arnold; Emily A Olsen; Lynne D Raymond; Didier Vilette; Byron Caughey
Comparison of protease-resistant prion protein inhibitors in cell cultures infected with two strains of mouse and sheep scrapie.
Neuroscience letters 2005;388(2):106-11.
2005: Jay R Silveira; Gregory J Raymond; Andrew G Hughson; Richard E Race; Valerie L Sim; Stanley F Hayes; Byron Caughey
The most infectious prion protein particles.
Nature 2005;437(7056):257-61.
2005: Bruce Chesebro; Matthew J Trifilo; Richard E Race; Kimberly Meade-White; Chao Teng; Rachel LaCasse; Lynne Raymond; Cynthia Favara; Gerald Baron; Suzette A Priola; Byron Caughey; Eliezer Masliah; Michael B A Oldstone
Anchorless prion protein results in infectious amyloid disease without clinical scrapie.
Science (New York, N.Y.) 2005;308(5727):1435-9.
2005: Ana C Magalhães; Gerald S Baron; Kil Sun Lee; Olivia Steele-Mortimer; David W Dorward; Marco Prado; Byron Caughey
Uptake and neuritic transport of scrapie prion protein coincident with infection of neuronal cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(21):5207-16.
2004: David Kocisko; John D Morrey; Richard E Race; Jiancao Chen; Byron Caughey
Evaluation of new cell culture inhibitors of protease-resistant prion protein against scrapie infection in mice.
The Journal of general virology 2004;85(Pt 8):2479-83.
2004: Jay R Silveira; Byron Caughey; Gerald S Baron
Prion protein and the molecular features of transmissible spongiform encephalopathy agents.
Current topics in microbiology and immunology 2004;284():1-50.
2003: Laura Maxson; Caíne Wong; Lynn M Herrmann; Byron Caughey; Gerald S Baron
A solid-phase assay for identification of modulators of prion protein interactions.
Analytical biochemistry 2003;323(1):54-64.
2003: Byron Caughey; David Kocisko
Prion diseases: a nucleic-acid accomplice?
Nature 2003;425(6959):673-4.
2003: David Kocisko; Gerald S Baron; Richard Rubenstein; Jiancao Chen; Salomon Kuizon; Byron Caughey
New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products.
Journal of virology 2003;77(19):10288-94.
2003: Derek E Dimcheff; John L Portis; Byron Caughey
Prion proteins meet protein quality control.
Trends in cell biology 2003;13(7):337-40.
2003: Suzette A Priola; Bruce Chesebro; Byron Caughey
Biomedicine. A view from the top--prion diseases from 10,000 feet.
Science (New York, N.Y.) 2003;300(5621):917-9.
2003: Byron Caughey; Lynne D Raymond; Gregory J Raymond; Laura Maxson; Jay R Silveira; Gerald S Baron
Inhibition of protease-resistant prion protein accumulation in vitro by curcumin.
Journal of virology 2003;77(9):5499-502.
2003: Gerald S Baron; Byron Caughey
Effect of glycosylphosphatidylinositol anchor-dependent and -independent prion protein association with model raft membranes on conversion to the protease-resistant isoform.
The Journal of biological chemistry 2003;278(17):14883-92.
2003: Jonathan O Speare; Thomas S Rush; Marshall E Bloom; Byron Caughey
The role of helix 1 aspartates and salt bridges in the stability and conversion of prion protein.
The Journal of biological chemistry 2003;278(14):12522-9.
2003: Byron Caughey
Prion protein conversions: insight into mechanisms, TSE transmission barriers and strains.
British medical bulletin 2003;66():109-20.
2003: Byron Caughey; Peter T Lansbury
Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders.
Annual review of neuroscience 2003;26():267-98.
2002: Richard E Race; Kimberly Meade-White; Anne Raines; Gregory J Raymond; Byron Caughey; Bruce Chesebro
Subclinical scrapie infection in a resistant species: persistence, replication, and adaptation of infectivity during four passages.
The Journal of infectious diseases 2002;186 Suppl 2():S166-70.
2002: Ervin Welker; Lynne D Raymond; Harold A Scheraga; Byron Caughey
Intramolecular versus intermolecular disulfide bonds in prion proteins.
The Journal of biological chemistry 2002;277(36):33477-81.
2002: Byron Caughey; Gerald S Baron
Factors affecting interactions between prion protein isoforms.
Biochemical Society transactions 2002;30(4):565-9.
2002: Gerald S Baron; Kathy Wehrly; David W Dorward; Bruce Chesebro; Byron Caughey
Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes.
The EMBO journal 2002;21(5):1031-40.
2001: Susan M Uptain; G J Sawicki; Byron Caughey; Susan Lindquist
Strains of [PSI(+)] are distinguished by their efficiencies of prion-mediated conformational conversion.
The EMBO journal 2001;20(22):6236-45.
2001: LW Xiong; Lynne D Raymond; Stanley F Hayes; Gregory J Raymond; Byron Caughey
Conformational change, aggregation and fibril formation induced by detergent treatments of cellular prion protein.
Journal of neurochemistry 2001;79(3):669-78.
2001: Richard E Race; Anne Raines; Gregory J Raymond; Byron Caughey; Bruce Chesebro
Long-term subclinical carrier state precedes scrapie replication and adaptation in a resistant species: analogies to bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease in humans.
Journal of virology 2001;75(21):10106-12.
2001: M A Callahan; L Xiong ; Byron Caughey
Reversibility of scrapie-associated prion protein aggregation.
The Journal of biological chemistry 2001;276(30):28022-8.
2001: M Horiuchi; Gerald S Baron; LW Xiong; Byron Caughey
Inhibition of interactions and interconversions of prion protein isoforms by peptide fragments from the C-terminal folded domain.
The Journal of biological chemistry 2001;276(18):15489-97.
2001: Byron Caughey
Interactions between prion protein isoforms: the kiss of death?
Trends in biochemical sciences 2001;26(4):235-42.
2001: Byron Caughey
Prion protein interconversions.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1406):197-200; discussion 200-2.
2001: Caíne Wong; LW Xiong; M Horiuchi; L Raymond; Kathy Wehrly; Bruce Chesebro; Byron Caughey
Sulfated glycans and elevated temperature stimulate PrP(Sc)-dependent cell-free formation of protease-resistant prion protein.
The EMBO journal 2001;20(3):377-86.
2001: Byron Caughey; Bruce Chesebro
Transmissible spongiform encephalopathies and prion protein interconversions.
Advances in virus research 2001;56():277-311.
2001: Byron Caughey; Gregory J Raymond; M A Callahan; Caíne Wong; Gerald S Baron; LW Xiong
Interactions and conversions of prion protein isoforms.
Advances in protein chemistry 2001;57():139-69.
2000: Gregory J Raymond; Alex Bossers; Lynne D Raymond; K I O'Rourke; Linda E McHolland; P K Bryant; Michael W Miller; Elizabeth S Williams; M Smits; Byron Caughey
Evidence of a molecular barrier limiting susceptibility of humans, cattle and sheep to chronic wasting disease.
The EMBO journal 2000;19(17):4425-30.
2000: Byron Caughey
Formation of protease-resistant prion protein in cell-free systems.
Current issues in molecular biology 2000;2(3):95-101.
2000: Byron Caughey
Transmissible spongiform encephalopathies, amyloidoses and yeast prions: common threads?
Nature medicine 2000;6(7):751-4.
2000: M Horiuchi; Suzette A Priola; Joëlle Chabry; Byron Caughey
Interactions between heterologous forms of prion protein: binding, inhibition of conversion, and species barriers.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):5836-41.
2000: R Demaimay; Bruce Chesebro; Byron Caughey
Inhibition of formation of protease-resistant prion protein by Trypan Blue, Sirius Red and other Congo Red analogs.
Archives of virology. Supplementum 2000;(16):277-83.
1999: M Horiuchi; Byron Caughey
Prion protein interconversions and the transmissible spongiform encephalopathies.
Structure (London, England : 1993) 1999;7(10):R231-40.
1999: Suzette A Priola; Byron Caughey; Winslow S Caughey
Novel therapeutic uses for porphyrins and phthalocyanines in the transmissible spongiform encephalopathies.
Current opinion in microbiology 1999;2(5):563-6.
1999: M Horiuchi; Byron Caughey
Specific binding of normal prion protein to the scrapie form via a localized domain initiates its conversion to the protease-resistant state.
The EMBO journal 1999;18(12):3193-203.
1999: Byron Caughey; M Horiuchi; R Demaimay; Gregory J Raymond
Assays of protease-resistant prion protein and its formation.
Methods in enzymology 1999;309():122-33.
1998: R Demaimay; J Harper; H Gordon; D Weaver; Bruce Chesebro; Byron Caughey
Structural aspects of Congo red as an inhibitor of protease-resistant prion protein formation.
Journal of neurochemistry 1998;71(6):2534-41.
1998: Byron Caughey; Gregory J Raymond; RA Bessen
Strain-dependent differences in beta-sheet conformations of abnormal prion protein.
The Journal of biological chemistry 1998;273(48):32230-5.
1998: Winslow S Caughey; Lynne D Raymond; M Horiuchi; Byron Caughey
Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12117-22.
1998: L M Herrmann; Byron Caughey
The importance of the disulfide bond in prion protein conversion.
Neuroreport 1998;9(11):2457-61.
1998: Joëlle Chabry; Byron Caughey; Bruce Chesebro
Specific inhibition of in vitro formation of protease-resistant prion protein by synthetic peptides.
The Journal of biological chemistry 1998;273(21):13203-7.
1997: S K DebBurman; Gregory J Raymond; Byron Caughey; Susan Lindquist
Chaperone-supervised conversion of prion protein to its protease-resistant form.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13938-43.
1997: Gregory J Raymond; James Hope; David Kocisko; Suzette A Priola; Lynne D Raymond; Alex Bossers; James Ironside; Robert G Will; S G Chen; R B Petersen; Pierluigi Gambetti; Richard Rubenstein; Mari A Smits; Peter T Lansbury; Byron Caughey
Molecular assessment of the potential transmissibilities of BSE and scrapie to humans.
Nature 1997;388(6639):285-8.
1997: RA Bessen; Gregory J Raymond; Byron Caughey
In situ formation of protease-resistant prion protein in transmissible spongiform encephalopathy-infected brain slices.
The Journal of biological chemistry 1997;272(24):15227-31.
1997: Alex Bossers; Gregory J Raymond; Byron Caughey; Ruth de Vries; Mari A Smits
Scrapie susceptibility-linked polymorphisms modulate the in vitro conversion of sheep prion protein to protease-resistant forms.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):4931-6.
1997: Byron Caughey; Gregory J Raymond; David Kocisko; Peter T Lansbury
Scrapie infectivity correlates with converting activity, protease resistance, and aggregation of scrapie-associated prion protein in guanidine denaturation studies.
Journal of virology 1997;71(5):4107-10.
1996: David Kocisko; Peter T Lansbury; Byron Caughey
Partial unfolding and refolding of scrapie-associated prion protein: evidence for a critical 16-kDa C-terminal domain.
Biochemistry 1996;35(41):13434-42.
1995: Byron Caughey; David Kocisko; Gregory J Raymond; Peter T Lansbury
Aggregates of scrapie-associated prion protein induce the cell-free conversion of protease-sensitive prion protein to the protease-resistant state.
Chemistry & biology 1995;2(12):807-17.
1995: RA Bessen; David Kocisko; Gregory J Raymond; S Nandan; Peter T Lansbury; Byron Caughey
Non-genetic propagation of strain-specific properties of scrapie prion protein.
Nature 1995;375(6533):698-700.
1995: David Kocisko; Suzette A Priola; Gregory J Raymond; Bruce Chesebro; Peter T Lansbury; Byron Caughey
Species specificity in the cell-free conversion of prion protein to protease-resistant forms: a model for the scrapie species barrier.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(9):3923-7.
1995: Suzette A Priola; Byron Caughey; Kathy Wehrly; Bruce Chesebro
A 60-kDa prion protein (PrP) with properties of both the normal and scrapie-associated forms of PrP.
The Journal of biological chemistry 1995;270(7):3299-305.
1995: Aichun Dong; P Huang; Byron Caughey; W S Caughey
Infrared analysis of ligand- and oxidation-induced conformational changes in hemoglobins and myoglobins.
Archives of biochemistry and biophysics 1995;316(2):893-8.
1995: Peter T Lansbury; Byron Caughey
The chemistry of scrapie infection: implications of the 'ice 9' metaphor.
Chemistry & biology 1995;2(1):1-5.
1994: David Kocisko; J H Come; Suzette A Priola; Bruce Chesebro; Gregory J Raymond; Peter T Lansbury; Byron Caughey
Cell-free formation of protease-resistant prion protein.
Nature 1994;370(6489):471-4.
1994: Suzette A Priola; Byron Caughey; Richard E Race; Bruce Chesebro
Heterologous PrP molecules interfere with accumulation of protease-resistant PrP in scrapie-infected murine neuroblastoma cells.
Journal of virology 1994;68(8):4873-8.
1994: Byron Caughey; R E Race
Scrapie-associated PrP accumulation and its inhibition: revisiting the amyloid-glycosaminoglycan connection.
Annals of the New York Academy of Sciences 1994;724():290-5.
1994: Suzette A Priola; Byron Caughey
Inhibition of scrapie-associated PrP accumulation. Probing the role of glycosaminoglycans in amyloidogenesis.
Molecular neurobiology 1994;8(2-3):113-20.
1994: Suzette A Priola; Byron Caughey; Gregory J Raymond; Bruce Chesebro
Prion protein and the scrapie agent: in vitro studies in infected neuroblastoma cells.
Infectious agents and disease 1994;3(2-3):54-8.
1994: Byron Caughey; K Brown; Gregory J Raymond; G E Katzenstein; W Thresher
Binding of the protease-sensitive form of PrP (prion protein) to sulfated glycosaminoglycan and congo red [corrected].
Journal of virology 1994;68(4):2135-41.
1994: Byron Caughey
Scrapie-associated PrP accumulation and agent replication: effects of sulphated glycosaminoglycan analogues.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1994;343(1306):399-404.
1993: Byron Caughey
Scrapie associated PrP accumulation and its prevention: insights from cell culture.
British medical bulletin 1993;49(4):860-72.
1993: Byron Caughey; D Ernst; Richard E Race
Congo red inhibition of scrapie agent replication.
Journal of virology 1993;67(10):6270-2.
1993: Byron Caughey; Gregory J Raymond
Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells.
Journal of virology 1993;67(2):643-50.
1993: Bruce Chesebro; Kathy Wehrly; Byron Caughey; J Nishio; D Ernst; Richard E Race
Foreign PrP expression and scrapie infection in tissue culture cell lines.
Developments in biological standardization 1993;80():131-40.
1992: Aichun Dong; Byron Caughey; W S Caughey; K S Bhat; J E Coe
Secondary structure of the pentraxin female protein in water determined by infrared spectroscopy: effects of calcium and phosphorylcholine.
Biochemistry 1992;31(39):9364-70.
1992: Byron Caughey; Richard E Race
Potent inhibition of scrapie-associated PrP accumulation by congo red.
Journal of neurochemistry 1992;59(2):768-71.
1992: Richard E Race; D Ernst; A Jenny; W Taylor; D Sutton; Byron Caughey
Diagnostic implications of detection of proteinase K-resistant protein in spleen, lymph nodes, and brain of sheep.
American journal of veterinary research 1992;53(6):883-9.
1991: Byron Caughey; Gregory J Raymond; D Ernst; Richard E Race
N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state.
Journal of virology 1991;65(12):6597-603.
1991: M N Robertson; Masaaki Miyazawa; S Mori; Byron Caughey; L H Evans; S F Hayes; Bruce Chesebro
Production of monoclonal antibodies reactive with a denatured form of the Friend murine leukemia virus gp70 envelope protein: use in a focal infectivity assay, immunohistochemical studies, electron microscopy and western blotting.
Journal of virological methods 1991;34(3):255-71.
1991: Byron Caughey; Gregory J Raymond
The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive.
The Journal of biological chemistry 1991;266(27):18217-23.
1991: Byron Caughey; Aichun Dong; K S Bhat; D Ernst; S F Hayes; W S Caughey
Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy.
Biochemistry 1991;30(31):7672-80.
1991: K Neary; Byron Caughey; D Ernst; Richard E Race; Bruce Chesebro
Protease sensitivity and nuclease resistance of the scrapie agent propagated in vitro in neuroblastoma cells.
Journal of virology 1991;65(2):1031-4.
1991: Byron Caughey
In vitro expression and biosynthesis of prion protein.
Current topics in microbiology and immunology 1991;172():93-107.
1990: Byron Caughey; K Neary; R Buller; D Ernst; L L Perry; Bruce Chesebro; Richard E Race
Normal and scrapie-associated forms of prion protein differ in their sensitivities to phospholipase and proteases in intact neuroblastoma cells.
Journal of virology 1990;64(3):1093-101.
1990: Richard E Race; K Graham; D Ernst; Byron Caughey; Bruce Chesebro
Analysis of linkage between scrapie incubation period and the prion protein gene in mice.
The Journal of general virology 1990;71 ( Pt 2)():493-7.
1989: Byron Caughey; Richard E Race; Bruce Chesebro
Comparative sequence analysis, in vitro expression and biosynthesis of mouse PrP.
Progress in clinical and biological research 1989;317():619-36.
1989: Byron Caughey; Richard E Race; D Ernst; M J Buchmeier; Bruce Chesebro
Prion protein biosynthesis in scrapie-infected and uninfected neuroblastoma cells.
Journal of virology 1989;63(1):175-81.
1988: Richard E Race; Byron Caughey; K Graham; D Ernst; Bruce Chesebro
Analyses of frequency of infection, specific infectivity, and prion protein biosynthesis in scrapie-infected neuroblastoma cell clones.
Journal of virology 1988;62(8):2845-9.
1988: Byron Caughey; Richard E Race; M Vogel; M J Buchmeier; Bruce Chesebro
In vitro expression in eukaryotic cells of a prion protein gene cloned from scrapie-infected mouse brain.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(13):4657-61.
1988: Byron Caughey; R E Race; B Chesebro
Detection of prion protein mRNA in normal and scrapie-infected tissues and cell lines.
The Journal of general virology 1988;69 ( Pt 3)():711-6.
1988: Byron Caughey; Richard E Race; M Vogel; M Buchmeier; Bruce Chesebro
In vitro expression of cloned PrP cDNA derived from scrapie-infected mouse brain: lack of transmission of scrapie infectivity.
Ciba Foundation symposium 1988;135():197-208.