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John Leonard Krstenansky

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TOP 3
John Leonard Krstenansky; I Cotterill
Recent advances in microwave-assisted organic syntheses.
John Leonard Krstenansky; Y Khmelnitsky
Biocatalytic combinatorial synthesis.
N S Sturm; Y Lin; S K Burley; John Leonard Krstenansky; JM Ahn; BY Azizeh; Dev Trivedi; Victor J Hruby
Structure-function studies on positions 17, 18, and 21 replacement analogues of glucagon: the importance of charged residues and salt bridges in glucagon biological activity.

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All Publications

2000: John Leonard Krstenansky; I Cotterill
Recent advances in microwave-assisted organic syntheses.
Current opinion in drug discovery & development 2000;3(4):454-61.
1999: John Leonard Krstenansky; Y Khmelnitsky
Biocatalytic combinatorial synthesis.
Bioorganic & medicinal chemistry 1999;7(10):2157-62.
1998: N S Sturm; Y Lin; S K Burley; John Leonard Krstenansky; JM Ahn; BY Azizeh; Dev Trivedi; Victor J Hruby
Structure-function studies on positions 17, 18, and 21 replacement analogues of glucagon: the importance of charged residues and salt bridges in glucagon biological activity.
Journal of medicinal chemistry 1998;41(15):2693-700.
1996: B H Vickery; Z Avnur; Y Cheng; S S Chiou; D Leaffer; J P Caulfield; D B Kimmel; T Ho; John Leonard Krstenansky
RS-66271, a C-terminally substituted analog of human parathyroid hormone-related protein (1-34), increases trabecular and cortical bone in ovariectomized, osteopenic rats.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1996;11(12):1943-51.
1996: S M Dankwardt; T M Phan; John Leonard Krstenansky
Combinatorial synthesis of small-molecule libraries using 3-amino-5-hydroxybenzoic acid.
Molecular diversity 1996;1(2):113-20.
1995: D Leaffer; M Sweeney; L A Kellerman; Z Avnur; John Leonard Krstenansky; B H Vickery; J P Caulfield
Modulation of osteogenic cell ultrastructure by RS-23581, an analog of human parathyroid hormone (PTH)-related peptide-(1-34), and bovine PTH-(1-34).
Endocrinology 1995;136(8):3624-31.
1994: S Sankarapandi; J K Woodford; John Leonard Krstenansky; L J Berliner
Binding of fluorescent and spin-labeled C-terminal hirudin analogs to thrombin.
Journal of medicinal chemistry 1994;37(22):3855-8.
1994: L Grundemar; John Leonard Krstenansky; Rolf Håkanson
Neuropeptide Y and truncated neuropeptide Y analogs evoke histamine release from rat peritoneal mast cells. A direct effect on G proteins?
European journal of pharmacology 1994;258(1-2):163-6.
1993: X Qiu; M Yin; K P Padmanabhan; John Leonard Krstenansky; Alexander Tulinsky
Structures of thrombin complexes with a designed and a natural exosite peptide inhibitor.
The Journal of biological chemistry 1993;268(27):20318-26.
1993: L Grundemar; John Leonard Krstenansky; Rolf Håkanson
Activation of neuropeptide Y1 and neuropeptide Y2 receptors by substituted and truncated neuropeptide Y analogs: identification of signal epitopes.
European journal of pharmacology 1993;232(2-3):271-8.
1993: L R McLean; J E Lewis; John Leonard Krstenansky; K A Hagaman; A S Cope; K F Olsen; E R Matthews; D C Uhrhammer; T J Owen; M H Payne
An amphipathic alpha-helical decapeptide in phosphatidylcholine is an effective synthetic lung surfactant.
The American review of respiratory disease 1993;147(2):462-5.
1992: J R Ngaiza; G Manley; J Grulich-Henn; John Leonard Krstenansky; E A Jaffe
The fibrinogen anion-binding exosite of thrombin is necessary for induction of rises in intracellular calcium and prostacyclin production in endothelial cells.
Journal of cellular physiology 1992;151(1):190-6.
1992: Bradley L Ackermann; R J Barbuch; J E Coutant; John Leonard Krstenansky; T J Owen
Evidence for a lysine-specific fragmentation in fast-atom bombardment mass spectra of peptides.
Rapid communications in mass spectrometry : RCM 1992;6(4):257-64.
1992: L R McLean; John Leonard Krstenansky; R L Jackson; K A Hagaman; K A Olsen; J E Lewis
Mixtures of synthetic peptides and dipalmitoylphosphatidylcholine as lung surfactants.
The American journal of physiology 1992;262(3 Pt 1):L292-300.
1992: R G Brankamp; G D Manley; T J Owen; John Leonard Krstenansky; A D Cardin
Specific inhibition of binding of antistasin and [A103,106,108] antistasin 93-119 to sulfatide (Gal(3-SO4)beta 1-1Cer) by glycosaminoglycans.
FEBS letters 1992;296(2):145-7.
1992: G D Manley; T J Owen; John Leonard Krstenansky; R G Brankamp; A D Cardin
Heparin binding properties of the carboxyl terminal domain of [A103,106,108] antistasin 93-119.
Advances in experimental medicine and biology 1992;313():135-40.
1991: R G Brankamp; G D Manley; T J Owen; John Leonard Krstenansky; P L Smith; A D Cardin
Demonstration that [A103,106,108] antistasin 93-119 inhibits the specific binding of antistasin to sulfatide [Gal(3-SO4)beta 1-1Cer].
Biochemical and biophysical research communications 1991;181(1):246-51.
1991: L R McLean; K A Hagaman; T J Owen; M H Payne; W S Davidson; John Leonard Krstenansky
Examination of the peptide sequence requirements for lipid-binding. Alternative pathways for promoting the interaction of amphipathic alpha-helical peptides with phosphatidylcholine.
Biochimica et biophysica acta 1991;1086(1):106-14.
1991: Martine Jandrot-Perrus; M G Huisse; John Leonard Krstenansky; Annie Bezeaud; Marie-Claude Guillin
Effect of the hirudin carboxy-terminal peptide 54-65 on the interaction of thrombin with platelets.
Thrombosis and haemostasis 1991;66(3):300-5.
1991: R J Broersma; L W Kutcher; E F Heminger; John Leonard Krstenansky; F N Marshall
Antithrombotic activity of a novel C-terminal hirudin analog in experimental animals.
Thrombosis and haemostasis 1991;66(2):269.
1991: R J Broersma; L W Kutcher; E F Heminger; John Leonard Krstenansky; F N Marshall
Antithrombotic activity of a novel C-terminal hirudin analog in experimental animals.
Thrombosis and haemostasis 1991;65(4):377-81.
1991: Helen M Cox; John Leonard Krstenansky
The effects of selective amino acid substitution upon neuropeptide Y antisecretory potency in rat jejunum mucosa.
Peptides 1991;12(2):323-7.
1991: M H Payne; John Leonard Krstenansky; M T Yates; S J Mao
Positional effects of sulfation in hirudin and hirudin PA related anticoagulant peptides.
Journal of medicinal chemistry 1991;34(3):1184-7.
1991: John Leonard Krstenansky; S J Mao
Structure-function relationships of the C-terminal functional domain of hirudin and its variants.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1991;2(1):91-6.
1991: L R McLean; K A Hagaman; T J Owen; John Leonard Krstenansky
Minimal peptide length for interaction of amphipathic alpha-helical peptides with phosphatidylcholine liposomes.
Biochemistry 1991;30(1):31-7.
1990: E A Gordon; John Leonard Krstenansky; P H Fishman
Centrally truncated neuropeptide Y analog acts as an agonist for Y1 receptors on SK-N-MC cells.
Neuroscience letters 1990;119(2):187-90.
1990: John Leonard Krstenansky; T J Owen; M H Payne; S A Shatzer; S H Buck
C-terminal modifications of neuropeptide Y and its analogs leading to selectivity for the mouse brain receptor over the porcine spleen receptor.
Neuropeptides 1990;17(3):117-20.
1990: John Leonard Krstenansky; T J Owen; M T Yates; S J Mao
The C-terminal binding domain of hirullin P18. Antithrombin activity and comparison to hirudin peptides.
FEBS letters 1990;269(2):425-9.
1990: S J Mao; A E Rechtin; John Leonard Krstenansky; R L Jackson
Characterization of a monoclonal antibody specific to the amino terminus of the alpha-chain of human fibrin.
Thrombosis and haemostasis 1990;63(3):445-8.
1990: L R McLean; B M Baron; S H Buck; John Leonard Krstenansky
Lipid and membrane interactions of neuropeptide Y.
Biochimica et biophysica acta 1990;1024(1):1-4.
1990: John Leonard Krstenansky; R J Broersma; T J Owen; M H Payne; M T Yates; S J Mao
Development of MDL 28,050, a small stable antithrombin agent based on a functional domain of the leech protein, hirudin.
Thrombosis and haemostasis 1990;63(2):208-14.
1990: L R McLean; S H Buck; John Leonard Krstenansky
Examination of the role of the amphipathic alpha-helix in the interaction of neuropeptide Y and active cyclic analogues with cell membrane receptors and dimyristoylphosphatidylcholine.
Biochemistry 1990;29(8):2016-22.
1990: Thue W Schwartz; J Fuhlendorff; L L Kjems; M S Kristensen; M Vervelde; M O'Hare; John Leonard Krstenansky; B Bjørnholm
Signal epitopes in the three-dimensional structure of neuropeptide Y. Interaction with Y1, Y2, and pancreatic polypeptide receptors.
Annals of the New York Academy of Sciences 1990;611():35-47.
1989: L R McLean; John Leonard Krstenansky; T J Owen; M R Eftink; K A Hagaman
Effect of micelle diameter on tryptophan dynamics in an amphipathic helical peptide in phosphatidylcholine.
Biochemistry 1989;28(21):8403-10.
1989: S J Mao; M T Yates; T J Owen; John Leonard Krstenansky
Preparation of antibodies to a synthetic C terminus of hirudin and identification of an antigenic site.
Journal of immunological methods 1989;120(1):45-50.
1989: John Leonard Krstenansky; T J Owen; S H Buck; K A Hagaman; L R McLean
Centrally truncated and stabilized porcine neuropeptide Y analogs: design, synthesis, and mouse brain receptor binding.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(12):4377-81.
1989: John Leonard Krstenansky; M H Payne; T J Owen; M T Yates; S J Mao
C-terminal peptide alcohol, acid and amide analogs of desulfato hirudin54-65 as antithrombin agents.
Thrombosis research 1989;54(4):319-25.
1989: John Leonard Krstenansky; T J Owen; K A Hagaman; L R McLean
Short model peptides having a high alpha-helical tendency: design and solution properties.
FEBS letters 1989;242(2):409-13.
1989: A D Cardin; D L Taylor; John Leonard Krstenansky; A S Tyms; R L Jackson
A heparin which binds to the envelope glycoprotein gp120 inhibits human immunodeficiency virus replication.
Transactions of the Association of American Physicians 1989;102():101-9.
1988: John Leonard Krstenansky; C Zechel; Dev Trivedi; Victor J Hruby
Importance of the C-terminal alpha-helical structure for glucagon's biological activity.
International journal of peptide and protein research 1988;32(6):468-75.
1988: John Leonard Krstenansky; T J Owen; M T Yates; S J Mao
Design, synthesis and antithrombin activity for conformationally restricted analogs of peptide anticoagulants based on the C-terminal region of the leech peptide, hirudin.
Biochimica et biophysica acta 1988;957(1):53-9.
1988: S J Mao; M T Yates; T J Owen; John Leonard Krstenansky
Interaction of hirudin with thrombin: identification of a minimal binding domain of hirudin that inhibits clotting activity.
Biochemistry 1988;27(21):8170-3.
1988: John Leonard Krstenansky; T J Owen; M T Yates; S J Mao
Comparison of hirudin and hirudin PA C-terminal fragments and related analogs as antithrombin agents.
Thrombosis research 1988;52(2):137-41.
1988: A D Cardin; Terry Bowlin; John Leonard Krstenansky
Inhibition of lymphocyte proliferation by synthetic peptides homologous to human plasma apolipoproteins B and E.
Biochemical and biophysical research communications 1988;154(2):741-5.
1988: T J Owen; John Leonard Krstenansky; M T Yates; S J Mao
N-terminal requirements of small peptide anticoagulants based on hirudin54-65.
Journal of medicinal chemistry 1988;31(5):1009-11.
1988: S H Buck; Rebecca PRUSS; John Leonard Krstenansky; P J Robinson; K A Stauderman
A tachykinin peptide receptor joins an elite club.
Trends in pharmacological sciences 1988;9(1):3-5.
1987: S H Buck; John Leonard Krstenansky
The dogfish peptides scyliorhinin I and scyliorhinin II bind with differential selectivity to mammalian tachykinin receptors.
European journal of pharmacology 1987;144(1):109-11.
1987: John Leonard Krstenansky; T J Owen; M T Yates; S J Mao
Anticoagulant peptides: nature of the interaction of the C-terminal region of hirudin with a noncatalytic binding site on thrombin.
Journal of medicinal chemistry 1987;30(9):1688-91.
1987: John Leonard Krstenansky; S H Buck
The synthesis, physical characterization and receptor binding affinity of neuropeptide Y (NPY).
Neuropeptides 1987;10(1):77-85.
1986: John Leonard Krstenansky; Dev Trivedi; Victor J Hruby
Importance of the 10-13 region of glucagon for its receptor interactions and activation of adenylate cyclase.
Biochemistry 1986;25(13):3833-9.