FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Douglas Cavener

Research Profile

Chemicals & Drugs

Living Beings

Concepts & Ideas

Molecular Sequence Data

Phenomena

Phosphorylation

Physiology

Anatomy

Endoplasmic Reticulum

Genes & Molecular Sequences

Amino Acid Sequences

Co-author Network

Publications

TOP 3
Mimi A Trinh; Ronald C Wek; Douglas R Cavener; Hanoch Kaphzan; Philippe Pierre; Eric Klann
Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility.
Atsushi Saito; Kimiko Ochiai; Shinichi Kondo; Kenji Tsumagari; Tomohiko Murakami; Douglas R Cavener; Kazunori Imaizumi
Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2.
Xu Xu; Sounak Gupta; Wenli Hu; Barbara C McGrath; Douglas R Cavener
Hyperthermia induces the ER stress pathway.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Douglas Cavener (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Mimi A Trinh; Ronald C Wek; Douglas R Cavener; Hanoch Kaphzan; Philippe Pierre; Eric Klann
Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility.
Cell reports 2012;1(6):676-88.
2011: Atsushi Saito; Kimiko Ochiai; Shinichi Kondo; Kenji Tsumagari; Tomohiko Murakami; Douglas R Cavener; Kazunori Imaizumi
Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2.
The Journal of biological chemistry 2011;286(6):4809-18.
2011: Xu Xu; Sounak Gupta; Wenli Hu; Barbara C McGrath; Douglas R Cavener
Hyperthermia induces the ER stress pathway.
PloS one 2011;6(8):e23740.
2010: Douglas R Cavener; Sounak Gupta; Barbara C McGrath
PERK in beta cell biology and insulin biogenesis.
Trends in endocrinology and metabolism: TEM 2010;21(12):714-21.
2010: Sounak Gupta; Barbara McGrath; Douglas R Cavener
PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway.
Diabetes 2010;59(8):1937-47.
2009: Piyawan Bunpo; Allison Dudley; Judy K Cundiff; Douglas R Cavener; Ronald C Wek; Tracy G Anthony
GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.
The Journal of biological chemistry 2009;284(47):32742-9.
2009: An N Dang Do; Scot R Kimball; Douglas R Cavener; Leonard S Jefferson
eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver.
Physiological genomics 2009;38(3):328-41.
2009: Sounak Gupta; Barbara McGrath; Douglas R Cavener
PERK regulates the proliferation and development of insulin-secreting beta-cell tumors in the endocrine pancreas of mice.
PloS one 2009;4(11):e8008.
2009: Daorong Feng; Jianwen Wei; Sounak Gupta; Barbara C McGrath; Douglas R Cavener
Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation.
BMC cell biology 2009;10():61.
2009: Douglas R Cavener
Sleeping Beauty, awake! Regulation of insulin gene expression by methylation of histone H3.
Diabetes 2009;58(1):28-9.
2008: Jianwen Wei; Xiaoyi Sheng; Daorong Feng; Barbara McGrath; Douglas R Cavener
PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation.
Journal of cellular physiology 2008;217(3):693-707.
2008: Ekaterina Bobrovnikova-Marjon; Georgia Hatzivassiliou; Christina Grigoriadou; Margarita Romero; Douglas R Cavener; Craig Thompson; J Alan Diehl
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(42):16314-9.
2008: Scot R Kimball; A N Dang Do; Lydia Kutzler; Douglas R Cavener; Leonard S Jefferson
Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis.
The Journal of biological chemistry 2008;283(6):3465-75.
2007: Ronald C Wek; Douglas R Cavener
Translational control and the unfolded protein response.
Antioxidants & redox signaling 2007;9(12):2357-71.
2007: Feifan Guo; Douglas R Cavener
The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid.
Cell metabolism 2007;5(2):103-14.
2007: Kaori Iida; Yulin Li; Barbara C McGrath; Ami Frank; Douglas R Cavener
PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice.
BMC cell biology 2007;8():38.
2007: Kaori Iida; Diana Cox-Foster; Xiaolong Yang; Wen-Ya Ko; Douglas R Cavener
Expansion and evolution of insect GMC oxidoreductases.
BMC evolutionary biology 2007;7():75.
2006: Francesca Fallarino; Ursula Grohmann; Sylvaine You; Barbara C McGrath; Douglas R Cavener; Carmine Vacca; Ciriana Orabona; Roberta Bianchi; Maria Laura Belladonna; Claudia Volpi; Maria C Fioretti; Paolo Puccetti
Tryptophan catabolism generates autoimmune-preventive regulatory T cells.
Transplant immunology 2006;17(1):58-60.
2006: Wei Zhang; Daorong Feng; Yulin Li; Kaori Iida; Barbara McGrath; Douglas R Cavener
PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.
Cell metabolism 2006;4(6):491-7.
2006: Valérie Senée; Claude Chelala; Sabine Duchatelet; Daorong Feng; Hervé Blanc; Jack-Christophe Cossec; Céline Charon; Marc Nicolino; Pascal Boileau; Douglas R Cavener; Pierre Bougnères; Doris Taha; Cécile Julier
Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism.
Nature genetics 2006;38(6):682-7.
2006: Francesca Fallarino; Ursula Grohmann; Sylvaine You; Barbara C McGrath; Douglas R Cavener; Carmine Vacca; Ciriana Orabona; Roberta Bianchi; Maria Laura Belladonna; Claudia Volpi; Pere Santamaria; Maria C Fioretti; Paolo Puccetti
The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):6752-61.
2006: Shun-Hsin Liang; Wei Zhang; Barbara C McGrath; Peichuan Zhang; Douglas R Cavener
PERK (eIF2alpha kinase) is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasis.
The Biochemical journal 2006;393(Pt 1):201-9.
2005: Cheri R Owen; Rita Kumar; Peichuan Zhang; Barbara C McGrath; Douglas R Cavener; Gary S Krause
PERK is responsible for the increased phosphorylation of eIF2alpha and the severe inhibition of protein synthesis after transient global brain ischemia.
Journal of neurochemistry 2005;94(5):1235-42.
2005: Shuzhen Hao; James W Sharp; Catherine M Ross-Inta; Brent J McDaniel; Tracy G Anthony; Ronald C Wek; Douglas R Cavener; Barbara C McGrath; John B Rudell; Thomas J Koehnle; Dorothy W Gietzen
Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex.
Science (New York, N.Y.) 2005;307(5716):1776-8.
2004: Tracy G Anthony; Brent J McDaniel; Rachel L Byerley; Barbara C McGrath; Douglas R Cavener; Margaret A McNurlan; Ronald C Wek
Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.
The Journal of biological chemistry 2004;279(35):36553-61.
2004: Hao-Yuan Jiang; Sheree A Wek; Barbara C McGrath; Dan Lu; Tsonwin Hai; Heather P Harding; Xiaozhong Wang; David Ron; Douglas R Cavener; Ronald C Wek
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response.
Molecular and cellular biology 2004;24(3):1365-77.
2004: Kaori Iida; Douglas R Cavener
Glucose dehydrogenase is required for normal sperm storage and utilization in female Drosophila melanogaster.
The Journal of experimental biology 2004;207(Pt 4):675-81.
2003: Hao-Yuan Jiang; Sheree A Wek; Barbara C McGrath; Donalyn Scheuner; Randal J Kaufman; Douglas R Cavener; Ronald C Wek
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses.
Molecular and cellular biology 2003;23(16):5651-63.
2003: Yulin Li; Kaori Iida; Jeff O'Neil; Peichuan Zhang; Sheng'ai Li; Ami Frank; Aryn Gabai; Frank Zambito; Shun-Hsin Liang; Clifford J Rosen; Douglas R Cavener
PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver.
Endocrinology 2003;144(8):3505-13.
2002: Peichuan Zhang; Barbara C McGrath; Jamie Reinert; Deanne S Olsen; Li Lei; Sangeeta Gill; Sheree A Wek; Krishna M Vattem; Ronald C Wek; Scot R Kimball; Leonard S Jefferson; Douglas R Cavener
The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.
Molecular and cellular biology 2002;22(19):6681-8.
2002: Peichuan Zhang; Barbara McGrath; Sheng'ai Li; Ami Frank; Frank Zambito; Jamie Reinert; Maureen Gannon; Kun Ma; Kelly McNaughton; Douglas R Cavener
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas.
Molecular and cellular biology 2002;22(11):3864-74.
2001: Rita Kumar; S Azam; Jonathon M. Sullivan; C Owen; Douglas R Cavener; Peichuan Zhang; David Ron; H P Harding; J J Chen; A Han; Blaine C White; Gary S Krause; Donald J DeGracia
Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK.
Journal of neurochemistry 2001;77(5):1418-21.
2001: B L Keplinger; X Guo; J Quine; Yue Feng; Douglas R Cavener
Complex organization of promoter and enhancer elements regulate the tissue- and developmental stage-specific expression of the Drosophila melanogaster Gld gene.
Genetics 2001;157(2):699-716.
2000: R Sood; A C Porter; D A Olsen; Douglas R Cavener; Ronald C Wek
A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha.
Genetics 2000;154(2):787-801.
1998: Deanne S Olsen; B Jordan; D Chen; Ronald C Wek; Douglas R Cavener
Isolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2alpha kinase.
Genetics 1998;149(3):1495-509.
1997: X Ye; P Fong; N Iizuka; D Choate; Douglas R Cavener
Ultrabithorax and Antennapedia 5' untranslated regions promote developmentally regulated internal translation initiation.
Molecular and cellular biology 1997;17(3):1714-21.
1997: S Qu; S E Perlaky; Edward L Organ; D Crawford; Douglas R Cavener
Mutations at the Ser50 residue of translation factor eIF-2alpha dominantly affect developmental rate, body weight, and viability of Drosophila melanogaster.
Gene expression 1997;6(6):349-60.
1996: B L Keplinger; A L Rabetoy; Douglas R Cavener
A somatic reproductive organ enhancer complex activates expression in both the developing and the mature Drosophila reproductive tract.
Developmental biology 1996;180(1):311-23.
1995: Roger F Duncan; Douglas R Cavener; Shimian Qu
Heat shock effects on phosphorylation of protein synthesis initiation factor proteins eIF-4E and eIF-2 alpha in Drosophila.
Biochemistry 1995;34(9):2985-97.
1994: X Ye; Douglas R Cavener
Isolation and characterization of the Drosophila melanogaster gene encoding translation-initiation factor eIF-2 beta.
Gene 1994;142(2):271-4.
1994: P Gunaratne; J L Ross; Q Zhang; E L Organ; Douglas R Cavener
An evolutionarily conserved palindrome in the Drosophila Gld promoter directs tissue-specific expression.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(7):2738-42.
1994: Shimian Qu; Douglas R Cavener
Isolation and characterization of the Drosophila melanogaster eIF-2 alpha gene encoding the alpha subunit of translation initiation factor eIF-2.
Gene 1994;140(2):239-42.
1994: J L Ross; P P Fong; Douglas R Cavener
Correlated evolution of the cis-acting regulatory elements and developmental expression of the Drosophila Gld gene in seven species from the subgroup melanogaster.
Developmental genetics 1994;15(1):38-50.
1993: J A Quine; P Gunaratne; E L Organ; B A Cavener; Douglas R Cavener
Tissue-specific regulatory elements of the Drosophila Gld gene.
Mechanisms of development 1993;42(1-2):3-13.
1992: N M Schiff; Yue Feng; J A Quine; P A Krasney; Douglas R Cavener
Evolution of the expression of the Gld gene in the reproductive tract of Drosophila.
Molecular biology and evolution 1992;9(6):1029-49.
1992: C P Schonbaum; E L Organ; Shimian Qu; Douglas R Cavener
The Drosophila melanogaster stranded at second (sas) gene encodes a putative epidermal cell surface receptor required for larval development.
Developmental biology 1992;151(2):431-45.
1992: Douglas R Cavener
Transgenic animal studies on the evolution of genetic regulatory circuitries.
BioEssays : news and reviews in molecular, cellular and developmental biology 1992;14(4):237-44.
1992: Douglas R Cavener
GMC oxidoreductases. A newly defined family of homologous proteins with diverse catalytic activities.
Journal of molecular biology 1992;223(3):811-4.
1992: L Yaich; William D Dupont; Douglas R Cavener; Fritz F Parl
Analysis of the PvuII restriction fragment-length polymorphism and exon structure of the estrogen receptor gene in breast cancer and peripheral blood.
Cancer research 1992;52(1):77-83.
1991: Yue Feng; N M Schiff; Douglas R Cavener
Organ-specific patterns of gene expression in the reproductive tract of Drosophila are regulated by the sex-determination genes.
Developmental biology 1991;146(2):451-60.
1991: B D Foster; Douglas R Cavener; Fritz F Parl
Binding analysis of the estrogen receptor to its specific DNA target site in human breast cancer.
Cancer research 1991;51(13):3405-10.
1991: Douglas R Cavener; Stuart C Ray
Eukaryotic start and stop translation sites.
Nucleic acids research 1991;19(12):3185-92.
1991: Yue Feng; L E Gunter; E L Organ; Douglas R Cavener
Translation initiation in Drosophila melanogaster is reduced by mutations upstream of the AUG initiator codon.
Molecular and cellular biology 1991;11(4):2149-53.
1991: Douglas R Cavener; P A Krasney
Drosophila glucose dehydrogenase and yeast alcohol oxidase are homologous and share N-terminal homology with other flavoenzymes.
Molecular biology and evolution 1991;8(1):144-50.
1990: D L Cox-Foster; C P Schonbaum; M T Murtha; Douglas R Cavener
Developmental expression of the glucose dehydrogenase gene in Drosophila melanogaster.
Genetics 1990;124(4):873-80.
1990: P A Krasney; C Carr; Douglas R Cavener
Evolution of the glucose dehydrogenase gene in Drosophila.
Molecular biology and evolution 1990;7(2):155-77.
1989: Fritz F Parl; Douglas R Cavener; William D Dupont
Genomic DNA analysis of the estrogen receptor gene in breast cancer.
Breast cancer research and treatment 1989;14(1):57-64.
1989: M T Murtha; Douglas R Cavener
Ecdysteroid regulation of glucose dehydrogenase and alcohol dehydrogenase gene expression in Drosophila melanogaster.
Developmental biology 1989;135(1):66-73.
1988: R Whetten; E Organ; P Krasney; D Cox-Foster; Douglas R Cavener
Molecular structure and transformation of the glucose dehydrogenase gene in Drosophila melanogaster.
Genetics 1988;120(2):475-84.
1988: Douglas R Cavener; Yue Feng; B Foster; P Krasney; M Murtha; C Schonbaum; X Xiao
The YYRR box: a conserved dipyrimidine-dipurine sequence element in Drosophila and other eukaryotes.
Nucleic acids research 1988;16(8):3375-90.
1987: Fritz F Parl; C P Schonbaum; D L Cox; Douglas R Cavener
Detection of estrogen receptor mRNA in human uterus.
Molecular and cellular endocrinology 1987;52(3):235-42.
1986: Douglas R Cavener; G Corbett; D Cox; R Whetten
Isolation of the eclosion gene cluster and the developmental expression of the Gld gene in Drosophila melanogaster.
The EMBO journal 1986;5(11):2939-48.
1985: Douglas R Cavener
Coevolution of the glucose dehydrogenase gene and the ejaculatory duct in the genus Drosophila.
Molecular biology and evolution 1985;2(2):141-9.
1983: Douglas R Cavener
The Response of Enzyme Polymorphisms to Developmental Rate Selection in DROSOPHILA MELANOGASTER.
Genetics 1983;105(1):105-13.