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Tim Cawston

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
38
Rowan, Andrew
29
Clark, Ian
13
Bigg, Heather
12
Hui, Wang
9
Koshy, P J T
8
Milner, Jennifer
7
Jones, Debra
7
Lakey, Rachel
7
Catterall, Jon
7
Shingleton, WD
6
Young, David
5
Ward, Chris
5
Young-Min, Steven
5
Corris, Paul
5
Forrest, Ian

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Publications

TOP 3
Lakey Rachel L; Cawston Tim E
Sulfasalazine blocks the release of proteoglycan and collagen from cytokine stimulated cartilage and down-regulates metalloproteinases.
Lakey Rachel L; Morgan Tanya G; Rowan Andrew D; Isaacs John D; Cawston Tim E; Hilkens Catharien M U
A novel paradigm for dendritic cells as effectors of cartilage destruction.
Cawston Tim E
Measurement of activity of collagenolytic MMP and inhibitors of MMPs using radiolabeled collagen substrate.

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All Publications

2009: Lakey Rachel L; Cawston Tim E
Sulfasalazine blocks the release of proteoglycan and collagen from cytokine stimulated cartilage and down-regulates metalloproteinases.
Rheumatology (Oxford, England) 2009;48(10):1208-12.
2009: Lakey Rachel L; Morgan Tanya G; Rowan Andrew D; Isaacs John D; Cawston Tim E; Hilkens Catharien M U
A novel paradigm for dendritic cells as effectors of cartilage destruction.
Rheumatology (Oxford, England) 2009;48(5):502-7.
2009: Cawston Tim E
Measurement of activity of collagenolytic MMP and inhibitors of MMPs using radiolabeled collagen substrate.
Nature protocols 2009;4(3):286-90.
2008: Murphy Desmond M; Forrest Ian A; Corris Paul A; Johnson Gail E; Small Therese; Jones Debbie; Fisher Andrew J; Egan Jim J; Cawston Timothy E; Lordan James L; Ward Chris
Azithromycin attenuates effects of lipopolysaccharide on lung allograft bronchial epithelial cells.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2008;27(11):1210-6.
2008: Zhang Q; Hui W; Litherland G J; Barter M J; Davidson R; Darrah C; Donell S T; Clark I M; Cawston T E; Robinson J H; Rowan A D; Young D A
Differential Toll-like receptor-dependent collagenase expression in chondrocytes.
Annals of the rheumatic diseases 2008;67(11):1633-41.
2008: Litherland Gary J; Dixon Craig; Lakey Rachel L; Robson Timothy; Jones Debra; Young David A; Cawston Tim E; Rowan Andrew D
Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent.
The Journal of biological chemistry 2008;283(21):14221-9.
2007: Sukkar T Z; Thomason J M; Cawston T E; Lakey R; Jones D; Catterall J; Seymour R A
Gingival fibroblasts grown from cyclosporin-treated patients show a reduced production of matrix metalloproteinase-1 (MMP-1) compared with normal gingival fibroblasts, and cyclosporin down-regulates the production of MMP-1 stimulated by pro-inflammatory cytokines.
Journal of periodontal research 2007;42(6):580-8.
2007: Young-Min Steven; Cawston Tim; Marshall Nicola; Coady David; Christgau Stephan; Saxne Tore; Robins Simon; Griffiths Ian
Biomarkers predict radiographic progression in early rheumatoid arthritis and perform well compared with traditional markers.
Arthritis and rheumatism 2007;56(10):3236-47.
2007: Murphy Desmond M; Forrest Ian A; Ward Chris; Corris Paul A; Johnson Gail E; Jones Debbie; Fisher Andrew J; Egan Jim J; Cawston Timothy E; Lordan James L
Effect of azithromycin on primary bronchial epithelial cells derived from stable lung allografts.
Thorax 2007;62(9):834.
2007: Kloppenburg Margreet; Stamm Tanja; Watt Iain; Kainberger Franz; Cawston Tim E; Birrell Fraser N; Petersson Ingemar F; Saxne Tore; Kvien Tore K; Slatkowsky-Christensen Barbara; Dougados Maxime; Gossec Laure; Breedveld Ferdinand C; Smolen Josef S
Research in hand osteoarthritis: time for reappraisal and demand for new strategies. An opinion paper.
Annals of the rheumatic diseases 2007;66(9):1157-61.
2007: Bigg Heather F; Rowan Andrew D; Barker Michael D; Cawston Tim E
Activity of matrix metalloproteinase-9 against native collagen types I and III.
The FEBS journal 2007;274(5):1246-55.
2007: Cawston Tim E; Morgan Tanya G
Assessment of collagenase activity in cartilage.
Methods in molecular medicine 2007;135():211-26.
2006: Murphy Des M; Ward Chris; Forrest Ian A; Pritchard Gail; Jones Debbie; Stovold Rachel; Fisher Andrew J; Cawston Tim E; Lordan Jim L; Corris Paul A
The phosphodiesterase type IV inhibitor cilomilast decreases pro-inflammatory cytokine production from primary bronchial epithelial cells in lung transplantation patients.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2006;25(12):1436-40.
2006: Peake N J; Khawaja K; Myers A; Nowell M A; Jones S A; Rowan A D; Cawston T E; Foster H E
Interleukin-6 signalling in juvenile idiopathic arthritis is limited by proteolytically cleaved soluble interleukin-6 receptor.
Rheumatology (Oxford, England) 2006;45(12):1485-9.
2006: Barksby H E; Milner J M; Patterson A M; Peake N J; Hui W; Robson T; Lakey R; Middleton J; Cawston T E; Richards C D; Rowan A D
Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: implications for cartilage degradation in arthritis.
Arthritis and rheumatism 2006;54(10):3244-53.
2006: Cawston Tim E; Wilson Amy J
Understanding the role of tissue degrading enzymes and their inhibitors in development and disease.
Best practice & research. Clinical rheumatology 2006;20(5):983-1002.
2006: Catterall J B; Rowan A D; Sarsfield S; Saklatvala J; Wait R; Cawston T E
Development of a novel 2D proteomics approach for the identification of proteins secreted by primary chondrocytes after stimulation by IL-1 and oncostatin M.
Rheumatology (Oxford, England) 2006;45(9):1101-9.
2006: Shingleton W D; Jones D; Xu X; Cawston T E; Rowan A D
Retinoic acid and oncostatin M combine to promote cartilage degradation via matrix metalloproteinase-13 expression in bovine but not human chondrocytes.
Rheumatology (Oxford, England) 2006;45(8):958-65.
2006: Bigg Heather F; Wait Robin; Rowan Andrew D; Cawston Tim E
The mammalian chitinase-like lectin, YKL-40, binds specifically to type I collagen and modulates the rate of type I collagen fibril formation.
The Journal of biological chemistry 2006;281(30):21082-95.
2006: Peake N J; Foster H E; Khawaja K; Cawston T E; Rowan A D
Assessment of the clinical significance of gelatinase activity in patients with juvenile idiopathic arthritis using quantitative protein substrate zymography.
Annals of the rheumatic diseases 2006;65(4):501-7.
2006: Barksby H E; Hui W; Wappler I; Peters H H; Milner J M; Richards C D; Cawston T E; Rowan A D
Interleukin-1 in combination with oncostatin M up-regulates multiple genes in chondrocytes: implications for cartilage destruction and repair.
Arthritis and rheumatism 2006;54(2):540-50.
2006: Morgan T G; Rowan A D; Dickinson S C; Jones D; Hollander A P; Deehan D; Cawston T E
Human nasal cartilage responds to oncostatin M in combination with interleukin 1 or tumour necrosis factor alpha by the release of collagen fragments via collagenases.
Annals of the rheumatic diseases 2006;65(2):184-90.
2006: Milner Jennifer M; Rowan Andrew D; Cawston Tim E; Young David A
Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis.
Arthritis research & therapy 2006;8(5):R142.
2006: Milner Jennifer M; Kevorkian Lara; Young David A; Jones Debra; Wait Robin; Donell Simon T; Barksby Emma; Patterson Angela M; Middleton Jim; Cravatt Benjamin F; Clark Ian M; Rowan Andrew D; Cawston Timothy E
Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis.
Arthritis research & therapy 2006;8(1):R23.
2005: Forrest I A; Murphy D M; Ward C; Jones D; Johnson G E; Archer L; Gould F K; Cawston T E; Lordan J L; Corris P A
Primary airway epithelial cell culture from lung transplant recipients.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2005;26(6):1080-5.
2005: Peake N J; Khawaja K; Myers A; Jones D; Cawston T E; Rowan A D; Foster H E
Levels of matrix metalloproteinase (MMP)-1 in paired sera and synovial fluids of juvenile idiopathic arthritis patients: relationship to inflammatory activity, MMP-3 and tissue inhibitor of metalloproteinases-1 in a longitudinal study.
Rheumatology (Oxford, England) 2005;44(11):1383-9.
2005: Hui W; Barksby H E; Young D A; Cawston T E; McKie N; Rowan A D
Oncostatin M in combination with tumour necrosis factor {alpha} induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2.
Annals of the rheumatic diseases 2005;64(11):1624-32.
2005: Ward C; Forrest I A; Murphy D M; Johnson G E; Robertson H; Cawston T E; Fisher A J; Dark J H; Lordan J L; Kirby J A; Corris P A
Phenotype of airway epithelial cells suggests epithelial to mesenchymal cell transition in clinically stable lung transplant recipients.
Thorax 2005;60(10):865-71.
2005: Milner Jennifer M; Cawston Tim E
Matrix metalloproteinase knockout studies and the potential use of matrix metalloproteinase inhibitors in the rheumatic diseases.
Current drug targets. Inflammation and allergy 2005;4(3):363-75.
2005: Young David A; Lakey Rachel L; Pennington Caroline J; Jones Debra; Kevorkian Lara; Edwards Dylan R; Cawston Timothy E; Clark Ian M
Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption.
Arthritis research & therapy 2005;7(3):R503-12.
2005: Hui Wang; Cawston Tim E; Richards Carl D; Rowan Andrew D
A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANKL.
Arthritis research & therapy 2005;7(1):R57-64.
2004: Myers A; Lakey R; Cawston T E; Kay L J; Walker D J
Serum MMP-1 and TIMP-1 levels are increased in patients with psoriatic arthritis and their siblings.
Rheumatology (Oxford, England) 2004;43(3):272-6.
2003: Hui W; Rowan A D; Richards C D; Cawston T E
Oncostatin M in combination with tumor necrosis factor alpha induces cartilage damage and matrix metalloproteinase expression in vitro and in vivo.
Arthritis and rheumatism 2003;48(12):3404-18.
2003: Rowan Andrew D; Hui Wang; Cawston Tim E; Richards Carl D
Adenoviral gene transfer of interleukin-1 in combination with oncostatin M induces significant joint damage in a murine model.
The American journal of pathology 2003;162(6):1975-84.
2003: Hyland Paula L; Traynor Patrick S; Myrillas Theofilos T; Marley John J; Linden Gerard J; Winter Paul; Leadbetter Nicola; Cawston Timothy E; Irwin Chris R
The effects of cyclosporin on the collagenolytic activity of gingival fibroblasts.
Journal of periodontology 2003;74(4):437-45.
2003: Milner J M; Rowan A D; Elliott S-F; Cawston T E
Inhibition of furin-like enzymes blocks interleukin-1alpha/oncostatin M-stimulated cartilage degradation.
Arthritis and rheumatism 2003;48(4):1057-66.
2003: Young-Min Steven A; Shakhapur Sanjeev; Marshall Nicky; Griffiths Ian; Cawston Tim; Grainger Andrew
Modified Larsen scoring of digitized radiographs in rheumatoid arthritis.
The Journal of rheumatology 2003;30(2):238-40.
2003: Hui W; Cawston T; Rowan A D
Transforming growth factor beta 1 and insulin-like growth factor 1 block collagen degradation induced by oncostatin M in combination with tumour necrosis factor alpha from bovine cartilage.
Annals of the rheumatic diseases 2003;62(2):172-4.
2003: Cawston Tim E; Milner Jenny M; Catterall Jon B; Rowan Andrew D
Cytokine synergy, collagenases and cartilage collagen breakdown.
Biochemical Society symposium 2003;(70):125-33.
2003: Catterall Jon B; Cawston Tim E
Assays of matrix metalloproteinases (MMPs) and MMP inhibitors: bioassays and immunoassays applicable to cell culture medium, serum, and synovial fluid.
Methods in molecular biology (Clifton, N.J.) 2003;225():353-64.
2003: Catterall Jon B; Cawston Tim E
Drugs in development: bisphosphonates and metalloproteinase inhibitors.
Arthritis research & therapy 2003;5(1):12-24.
2002: Koshy P J; Henderson N; Logan C; Life P F; Cawston T E; Rowan A D
Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines.
Annals of the rheumatic diseases 2002;61(8):704-13.
2002: Irwin Chris R; Myrillas Theofilos T; Traynor Patrick; Leadbetter Nicola; Cawston Timothy E
The role of soluble interleukin (IL)-6 receptor in mediating the effects of IL-6 on matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 expression by gingival fibroblasts.
Journal of periodontology 2002;73(7):741-7.
2002: Koshy P J T; Lundy C J; Rowan A D; Porter S; Edwards D R; Hogan A; Clark I M; Cawston T E
The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: a time-course study using real-time quantitative reverse transcription-polymerase chain reaction.
Arthritis and rheumatism 2002;46(4):961-7.
2002: Vaidya B; Pearce S H S; Charlton S; Marshall N; Rowan A D; Griffiths I D; Kendall-Taylor P; Cawston T E; Young-Min S
An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune endocrinopathies.
Rheumatology (Oxford, England) 2002;41(2):180-3.
2001: Hui W; Rowan A D; Cawston T
Modulation of the expression of matrix metalloproteinase and tissue inhibitors of metalloproteinases by TGF-beta1 and IGF-1 in primary human articular and bovine nasal chondrocytes stimulated with TNF-alpha.
Cytokine 2001;16(1):31-5.
2001: Catterall J B; Carrère S; Koshy P J; Degnan B A; Shingleton W D; Brinckerhoff C E; Rutter J; Cawston T E; Rowan A D
Synergistic induction of matrix metalloproteinase 1 by interleukin-1alpha and oncostatin M in human chondrocytes involves signal transducer and activator of transcription and activator protein 1 transcription factors via a novel mechanism.
Arthritis and rheumatism 2001;44(10):2296-310.
2001: Cunnane G; Fitzgerald O; Beeton C; Cawston T E; Bresnihan B
Early joint erosions and serum levels of matrix metalloproteinase 1, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 in rheumatoid arthritis.
Arthritis and rheumatism 2001;44(10):2263-74.
2001: Milner J M; Elliott S F; Cawston T E
Activation of procollagenases is a key control point in cartilage collagen degradation: interaction of serine and metalloproteinase pathways.
Arthritis and rheumatism 2001;44(9):2084-96.
2001: Young-Min S A; Beeton C; Laughton R; Plumpton T; Bartram S; Murphy G; Black C; Cawston T E
Serum TIMP-1, TIMP-2, and MMP-1 in patients with systemic sclerosis, primary Raynaud's phenomenon, and in normal controls.
Annals of the rheumatic diseases 2001;60(9):846-51.
2001: Rowan A D; Koshy P J; Shingleton W D; Degnan B A; Heath J K; Vernallis A B; Spaull J R; Life P F; Hudson K; Cawston T E
Synergistic effects of glycoprotein 130 binding cytokines in combination with interleukin-1 on cartilage collagen breakdown.
Arthritis and rheumatism 2001;44(7):1620-32.
2001: Young-Min S A; Cawston T E; Griffiths I D
Markers of joint destruction: principles, problems, and potential.
Annals of the rheumatic diseases 2001;60(6):545-8.
2001: Hui W; Rowan A D; Cawston T
Insulin-like growth factor 1 blocks collagen release and down regulates matrix metalloproteinase-1, -3, -8, and -13 mRNA expression in bovine nasal cartilage stimulated with oncostatin M in combination with interleukin 1alpha.
Annals of the rheumatic diseases 2001;60(3):254-61.
2001: Elliott S; Rowan A D; Carrère S; Koshy P; Catterall J B; Cawston T E
Esculetin inhibits cartilage resorption induced by interleukin 1alpha in combination with oncostatin M.
Annals of the rheumatic diseases 2001;60(2):158-65.
2001: Cleaver C S; Rowan A D; Cawston T E
Interleukin 13 blocks the release of collagen from bovine nasal cartilage treated with proinflammatory cytokines.
Annals of the rheumatic diseases 2001;60(2):150-7.
2001: Elliott S; Cawston T
The clinical potential of matrix metalloproteinase inhibitors in the rheumatic disorders.
Drugs & aging 2001;18(2):87-99.
2001: Cawston T E; Koshy P; Rowan A D
Assay of matrix metalloproteinases against matrix substrates.
Methods in molecular biology (Clifton, N.J.) 2001;151():389-97.
2001: Cawston T; Carrere S; Catterall J; Duggleby R; Elliott S; Shingleton B; Rowan A
Matrix metalloproteinases and TIMPs: properties and implications for the treatment of chronic obstructive pulmonary disease.
Novartis Foundation symposium 2001;234():205-18; discussion 218-28.
2000: Shingleton W D; Ellis A J; Rowan A D; Cawston T E
Retinoic acid combines with interleukin-1 to promote the degradation of collagen from bovine nasal cartilage: matrix metalloproteinases-1 and -13 are involved in cartilage collagen breakdown.
Journal of cellular biochemistry 2000;79(4):519-31.
2000: Bigg H F; McLeod R; Waters J G; Cawston T E; Clark I M
Mechanisms of induction of human tissue inhibitor of metalloproteinases-1 (TIMP-1) gene expression by all-trans retinoic acid in combination with basic fibroblast growth factor.
European journal of biochemistry / FEBS 2000;267(13):4150-6.
2000: Hui W; Rowan A D; Cawston T
Transforming growth factor beta1 blocks the release of collagen fragments from boving nasal cartilage stimulated by oncostatin M in combination with IL-1alpha.
Cytokine 2000;12(6):765-9.
1999: Koshy P J; Rowan A D; Life P F; Cawston T E
96-Well plate assays for measuring collagenase activity using (3)H-acetylated collagen.
Analytical biochemistry 1999;275(2):202-7.
1999: Bigg H F; McLeod R; Waters J; Cawston T E; Nolan J F; Clark I M
Induction of human tissue inhibitor of metalloproteinase-1 gene expression by all-trans retinoic acid in combination with basic fibroblast growth factor involves both p42/44 and p38 MAP kinases.
Annals of the New York Academy of Sciences 1999;878():506-9.
1999: Cawston T; Billington C; Cleaver C; Elliott S; Hui W; Koshy P; Shingleton B; Rowan A
The regulation of MMPs and TIMPs in cartilage turnover.
Annals of the New York Academy of Sciences 1999;878():120-9.
1998: Hodges D J; Reid D G; Rowan A D; Clark I M; Cawston T E
Preparation of recombinant tissue inhibitor of metalloproteinases-1 (TIMP-1) in high yield and identification of a hydrophobic surface feature.
European journal of biochemistry / FEBS 1998;257(3):562-9.
1998: Billington C J; Clark I M; Cawston T E
An aggrecan-degrading activity associated with chondrocyte membranes.
The Biochemical journal 1998;336 ( Pt 1)():207-12.
1998: Cawston T E; Curry V A; Summers C A; Clark I M; Riley G P; Life P F; Spaull J R; Goldring M B; Koshy P J; Rowan A D; Shingleton W D
The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint.
Arthritis and rheumatism 1998;41(10):1760-71.
1998: Cawston T E; Rowan A
Prevention of cartilage breakdown by matrix metalloproteinase inhibition--a realistic therapeutic target?
British journal of rheumatology 1998;37(4):353-6.
1997: Shingleton W D; Mackie E J; Cawston T E; Jeffcott L B
Cartilage canals in equine articular/epiphyseal growth cartilage and a possible association with dyschondroplasia.
Equine veterinary journal 1997;29(5):360-4.
1997: Clark I M; Rowan A D; Edwards D R; Bech-Hansen T; Mann D A; Bahr M J; Cawston T E
Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 1.
The Biochemical journal 1997;324 ( Pt 2)():611-7.
1997: Ridley S H; Sarsfield S J; Lee J C; Bigg H F; Cawston T E; Taylor D J; DeWitt D L; Saklatvala J
Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(7):3165-73.
1996: Cawston T E; Ellis A J; Bigg H; Curry V; Lean E; Ward D
Interleukin-4 blocks the release of collagen fragments from bovine nasal cartilage treated with cytokines.
Biochimica et biophysica acta 1996;1314(3):226-32.
1996: Riley G P; Harrall R L; Cawston T E; Hazleman B L; Mackie E J
Tenascin-C and human tendon degeneration.
The American journal of pathology 1996;149(3):933-43.
1996: Cawston T E; Ellis A J
Retinoic acid and interleukin-1 together promote the release of collagen fragments from bovine nasal cartilage in culture.
Annals of the New York Academy of Sciences 1996;785():219-23.
1996: Riley G P; Harrall R L; Constant C R; Cawston T E; Hazleman B L
Prevalence and possible pathological significance of calcium phosphate salt accumulation in tendon matrix degeneration.
Annals of the rheumatic diseases 1996;55(2):109-15.
1996: Cawston T E; Riley G P; Hazleman B L
Tendon lesions and soft tissue rheumatism--great outback or great opportunity?
Annals of the rheumatic diseases 1996;55(1):1-3.
1996: Bigg H F; Cawston T E
Effect of retinoic acid in combination with platelet-derived growth factor-BB or transforming growth factor-beta on tissue inhibitor of metalloproteinases and collagenase secretion from human skin and synovial fibroblasts.
Journal of cellular physiology 1996;166(1):84-93.
1996: Shingleton W D; Hodges D J; Brick P; Cawston T E
Collagenase: a key enzyme in collagen turnover.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1996;74(6):759-75.
1996: Cawston T E
Metalloproteinase inhibitors and the prevention of connective tissue breakdown.
Pharmacology & therapeutics 1996;70(3):163-82.
1995: O'Hare M C; Curry V A; Mitchell R E; Cawston T E
Stabilisation of purified human collagenase by site-directed mutagenesis.
Biochemical and biophysical research communications 1995;216(1):329-37.
1995: Cawston T E; Ellis A J; Humm G; Lean E; Ward D; Curry V
Interleukin-1 and oncostatin M in combination promote the release of collagen fragments from bovine nasal cartilage in culture.
Biochemical and biophysical research communications 1995;215(1):377-85.
1995: Plumpton T A; Clark I M; Plumpton C; Calvin J; Cawston T E
Development of an enzyme-linked immunosorbent assay to measure total TIMP-1 (free TIMP-1 and TIMP-1 in combination with matrix-metalloproteinases) and measurement of TIMP 1 and CRP in serum.
Clinica chimica acta; international journal of clinical chemistry 1995;240(2):137-54.
1995: Dalton S; Cawston T E; Riley G P; Bayley I J; Hazleman B L
Human shoulder tendon biopsy samples in organ culture produce procollagenase and tissue inhibitor of metalloproteinases.
Annals of the rheumatic diseases 1995;54(7):571-7.
1995: Cawston T E; Curry V; Ramsey S; Clark I M; Kyle V A; Adebajo A; Silverman B; Daymond T; Hazleman B L
The levels of collagenase, tissue inhibitor of metalloproteinases-1 (TIMP-1), collagenase approximately TIMP-1 complexes and glycosaminoglycan (GAG) in sequential samples of synovial fluid aspirated from patients with osteoarthritis.
Clinical and experimental rheumatology 1995;13(4):431-7.
1995: Li J; Brick P; O'Hare M C; Skarzynski T; Lloyd L F; Curry V A; Clark I M; Bigg H F; Hazleman B L; Cawston T E
Structure of full-length porcine synovial collagenase reveals a C-terminal domain containing a calcium-linked, four-bladed beta-propeller.
Structure (London, England : 1993) 1995;3(6):541-9.
1995: Bigg H F; Cawston T E
All-trans-retinoic acid interacts synergistically with basic fibroblast growth factor and epidermal growth factor to stimulate the production of tissue inhibitor of metalloproteinases from fibroblasts.
Archives of biochemistry and biophysics 1995;319(1):74-83.
1995: Clark I M; Mitchell R E; Powell L K; Bigg H F; Cawston T E; O'Hare M C
Recombinant porcine collagenase: purification and autolysis.
Archives of biochemistry and biophysics 1995;316(1):123-7.
1995: Adebajo A O; Cawston T E; Hazleman B L
Specificity of IgM antiglobulins produced in rheumatoid arthritis and tropical infections.
Clinical rheumatology 1995;14(1):37-40.
1995: Riley G P; Harrall R L; Watson P G; Cawston T E; Hazleman B L
Collagenase (MMP-1) and TIMP-1 in destructive corneal disease associated with rheumatoid arthritis.
Eye (London, England) 1995;9 ( Pt 6)():703-18.
1994: Clark I M; Powell L K; Cawston T E
Tissue inhibitor of metalloproteinases (TIMP-1) stimulates the secretion of collagenase from human skin fibroblasts.
Biochemical and biophysical research communications 1994;203(2):874-80.
1994: Hodges D J; Lee D C; Salter C J; Reid D G; Harper G P; Cawston T E
Purification and secondary structural analysis of tissue inhibitor of metalloproteinases-1.
Biochimica et biophysica acta 1994;1208(1):94-100.
1994: Bigg H F; Clark I M; Cawston T E
Fragments of human fibroblast collagenase: interaction with metalloproteinase inhibitors and substrates.
Biochimica et biophysica acta 1994;1208(1):157-65.
1994: Cawston T; Plumpton T; Curry V; Ellis A; Powell L
Role of TIMP and MMP inhibition in preventing connective tissue breakdown.
Annals of the New York Academy of Sciences 1994;732():75-83.
1994: Riley G P; Harrall R L; Constant C R; Chard M D; Cawston T E; Hazleman B L
Glycosaminoglycans of human rotator cuff tendons: changes with age and in chronic rotator cuff tendinitis.
Annals of the rheumatic diseases 1994;53(6):367-76.
1994: Riley G P; Harrall R L; Constant C R; Chard M D; Cawston T E; Hazleman B L
Tendon degeneration and chronic shoulder pain: changes in the collagen composition of the human rotator cuff tendons in rotator cuff tendinitis.
Annals of the rheumatic diseases 1994;53(6):359-66.
1994: Ellis A J; Curry V A; Powell E K; Cawston T E
The prevention of collagen breakdown in bovine nasal cartilage by TIMP, TIMP-2 and a low molecular weight synthetic inhibitor.
Biochemical and biophysical research communications 1994;201(1):94-101.
1994: Clark I M; Morrison J J; Hackett G A; Powell E K; Cawston T E; Smith S K
Tissue inhibitor of metalloproteinases: serum levels during pregnancy and labor, term and preterm.
Obstetrics and gynecology 1994;83(4):532-7.
1994: Ellis A J; Cawston T E; Mackie E J
The differential effects of stanozolol on human skin and synovial fibroblasts in vitro: DNA synthesis and receptor binding.
Agents and actions 1994;41(1-2):37-43.
1994: Morrison J J; Clark I M; Powell E K; Cawston T E; Hackett G A; Smith S K
Tissue collagenase: serum levels during pregnancy and parturition.
European journal of obstetrics, gynecology, and reproductive biology 1994;54(1):71-5.
1994: Chard M D; Cawston T E; Riley G P; Gresham G A; Hazleman B L
Rotator cuff degeneration and lateral epicondylitis: a comparative histological study.
Annals of the rheumatic diseases 1994;53(1):30-4.
1993: Cawston T
Blocking cartilage destruction with metalloproteinase inhibitors: a valid therapeutic target?
Annals of the rheumatic diseases 1993;52(11):769-70.
1993: Cawston T E; Bigg H F; Clark I M; Hazleman B L
Identification of tissue inhibitor of metalloproteinase-2 (TIMP-2)-progelatinase complex as the third metalloproteinase inhibitor peak in rheumatoid synovial fluid.
Annals of the rheumatic diseases 1993;52(3):177-81.
1993: Clark I M; Powell L K; Ramsey S; Hazleman B L; Cawston T E
The measurement of collagenase, tissue inhibitor of metalloproteinases (TIMP), and collagenase-TIMP complex in synovial fluids from patients with osteoarthritis and rheumatoid arthritis.
Arthritis and rheumatism 1993;36(3):372-9.
1992: Clark I M; Powell L K; Wright J K; Cawston T E; Hazleman B L
Monoclonal antibodies against human fibroblast collagenase and the design of an enzyme-linked immunosorbent assay to measure total collagenase.
Matrix (Stuttgart, Germany) 1992;12(6):475-80.
1992: Adebajo A O; Akinsola A; Maizels R M; Cawston T E; Hazleman B L
Rheumatoid factor and rheumatoid factor isotypes in loiasis with and without accompanying glomerulonephritis.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1992;86(6):667-9.
1992: Andrews H J; Plumpton T A; Harper G P; Cawston T E
A synthetic peptide metalloproteinase inhibitor, but not TIMP, prevents the breakdown of proteoglycan within articular cartilage in vitro.
Agents and actions 1992;37(1-2):147-54.
1992: Curry V A; Clark I M; Bigg H; Cawston T E
Large inhibitor of metalloproteinases (LIMP) contains tissue inhibitor of metalloproteinases (TIMP)-2 bound to 72,000-M(r) progelatinase.
The Biochemical journal 1992;285 ( Pt 1)():143-7.
1992: Clark I M; Wright J K; Cawston T E; Hazleman B L
Polyclonal antibodies against human fibroblast collagenase and the design of an enzyme-linked immunosorbent assay to measure TIMP-collagenase complex.
Matrix (Stuttgart, Germany) 1992;12(2):108-15.
1992: Ellis A J; Wright J K; Cawston T E; Hazleman B L
The differential responses of human skin and synovial fibroblasts to stanozolol in vitro: production of prostaglandin E2 and matrix metalloproteinases.
Agents and actions 1992;35(3-4):232-7.
1992: O'Hare M C; Clarke N J; Cawston T E
Production in Escherichia coli of porcine type-I collagenase as a fusion protein with beta-galactosidase.
Gene 1992;111(2):245-8.
1992: Clark I M; Cawston T E
Fragments of human fibroblast collagenase: purification and characterisation.
Matrix (Stuttgart, Germany). Supplement 1992;1():73.
1992: Uitto V J; Grenier D; Pan Y M; McBride B; Cawston T
The collagenolytic activity of Treponema denticola.
Matrix (Stuttgart, Germany). Supplement 1992;1():141-2.
1992: Adebajo A O; Cawston T E; Hazleman B L
Routine quantitation of rheumatoid factors: ELISA or nephelometry?
Scandinavian journal of rheumatology 1992;21(6):302-4.
1991: Wright J K; Clark I M; Cawston T E; Hazleman B L
The secretion of the tissue inhibitor of metalloproteinases (TIMP) by human synovial fibroblasts is modulated by all-trans-retinoic acid.
Biochimica et biophysica acta 1991;1133(1):25-30.
1991: Wright J K; Cawston T E; Hazleman B L
Transforming growth factor beta stimulates the production of the tissue inhibitor of metalloproteinases (TIMP) by human synovial and skin fibroblasts.
Biochimica et biophysica acta 1991;1094(2):207-10.
1991: O'Hare M C; Clarke N J; Cawston T E; Harper G P
Cloning of a cDNA for porcine type I collagenase and expression in E. coli.
Biochemical Society transactions 1991;19(3):288S.
1991: Clark I M; Wright J K; Cawston T E
The measurement of human collagenase-TIMP complex by enzyme immunoassay.
Biochemical Society transactions 1991;19(3):287S.
1991: Clark I M; Powell L K; Wright J K; Cawston T E
Polyclonal and monoclonal antibodies against human tissue inhibitor of metalloproteinases (TIMP) and the design of an enzyme-linked immunosorbent assay to measure TIMP.
Matrix (Stuttgart, Germany) 1991;11(2):76-85.
1991: Adebajo A O; Wright J K; Cawston T E; Hazleman B L
Rheumatoid factor quantitation: a comparison of ELISA and nephelometric methods.
Medical laboratory sciences 1991;48(1):47-51.
1990: Clarke N J; O'Hare M C; Cawston T E; Harper G P
Nucleotide sequence of a cDNA for porcine type I collagenase, obtained by PCR.
Nucleic acids research 1990;18(22):6703.
1990: Andrews H J; Bunning R A; Plumpton T A; Clark I M; Russell R G; Cawston T E
Inhibition of interleukin-1-induced collagenase production in human articular chondrocytes in vitro by recombinant human interferon-gamma.
Arthritis and rheumatism 1990;33(11):1733-8.
1990: Silverman B; Cawston T E; Page Thomas D P; Dingle J T; Hazleman B L
The sulphated glycosaminoglycan levels in synovial fluid aspirates in patients with acute and chronic joint disease.
British journal of rheumatology 1990;29(5):340-4.
1990: Kyle V; Chard M; Ramsey S; Cawston T E; Hazleman B L
Salmonella enteritidis causing joint sepsis.
Clinical rheumatology 1990;9(3):411-3.
1990: Cawston T E; Curry V A; Clark I M; Hazleman B L
Identification of a new metalloproteinase inhibitor that forms tight-binding complexes with collagenase.
The Biochemical journal 1990;269(1):183-7.
1990: Andrews H J; Cawston T E; Hazleman B L
Modulation of plasminogen activator production by interleukin 1: differential responses of fibroblasts derived from human skin and rheumatoid and non-rheumatoid synovium.
Biochimica et biophysica acta 1990;1051(1):84-93.
1990: Cawston T; McLaughlan P; Coughlan R; Kyle V; Hazleman B
Synovial fluids from infected joints contain metalloproteinase--tissue inhibitor of metalloproteinase (TIMP) complexes.
Biochimica et biophysica acta 1990;1033(1):96-102.
1989: Wright J K; Smith A J; Cawston T E; Hazleman B L
The effect of the anabolic steroid, stanozolol, on the production of procollagenase by human synovial and skin fibroblasts in vitro.
Agents and actions 1989;28(3-4):279-82.
1989: Lloyd L F; Skarzynski T; Wonacott A J; Cawston T E; Clark I M; Mannix C J; Harper G P
Crystallization and preliminary X-ray analysis of porcine synovial collagenase.
Journal of molecular biology 1989;210(1):237-8.
1989: Clark I M; Cawston T E
Fragments of human fibroblast collagenase. Purification and characterization.
The Biochemical journal 1989;263(1):201-6.
1989: Cawston T E; Weaver L; Coughlan R J; Kyle M V; Hazleman B L
Synovial fluids from infected joints contain active metalloproteinases and no inhibitory activity.
British journal of rheumatology 1989;28(5):386-92.
1989: Kyle V; Cawston T E; Hazleman B L
Erythrocyte sedimentation rate and C reactive protein in the assessment of polymyalgia rheumatica/giant cell arteritis on presentation and during follow up.
Annals of the rheumatic diseases 1989;48(8):667-71.
1989: Andrews H J; Edwards T A; Cawston T E; Hazleman B L
Transforming growth factor-beta causes partial inhibition of interleukin 1-stimulated cartilage degradation in vitro.
Biochemical and biophysical research communications 1989;162(1):144-50.
1988: Chard M D; Calvin J; Price C P; Cawston T E; Hazleman B L
Serum alpha 1 antichymotrypsin concentration as a marker of disease activity in rheumatoid arthritis.
Annals of the rheumatic diseases 1988;47(8):665-71.
1987: Cawston T E; McLaughlin P; Hazleman B L
Paired serum and synovial fluid values of alpha 2-macroglobulin and TIMP in rheumatoid arthritis.
British journal of rheumatology 1987;26(5):354-8.

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