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Kathleen Brummel-Ziedins

Research Profile

Chemicals & Drugs

Physiology

Concepts & Ideas

Disorders

Hemophilia A

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Publications

TOP 3
Jonathan H Foley; Kenneth G Mann; Kelley C McLean; Thomas Orfeo; Georges-Etienne Rivard; Anetta Undas; Ira M Bernstein; Stephen J Everse; Kathleen E Brummel-Ziedins
From principle to practice: bridging the gap in patient profiling.
Kelley C McLean; Ira M Bernstein; Kathleen E Brummel-Ziedins
Tissue factor-dependent thrombin generation across pregnancy.
J H Foley; M E Nesheim; G E Rivard; Kathleen E Brummel-Ziedins
Thrombin activatable fibrinolysis inhibitor activation and bleeding in haemophilia A.

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All Publications

2013: Jonathan H Foley; Kenneth G Mann; Kelley C McLean; Thomas Orfeo; Georges-Etienne Rivard; Anetta Undas; Ira M Bernstein; Stephen J Everse; Kathleen E Brummel-Ziedins
From principle to practice: bridging the gap in patient profiling.
PloS one 2013;8(1):e54728.
2012: Kelley C McLean; Ira M Bernstein; Kathleen E Brummel-Ziedins
Tissue factor-dependent thrombin generation across pregnancy.
American journal of obstetrics and gynecology 2012;207(2):135.e1-6.
2012: J H Foley; M E Nesheim; G E Rivard; Kathleen E Brummel-Ziedins
Thrombin activatable fibrinolysis inhibitor activation and bleeding in haemophilia A.
Haemophilia : the official journal of the World Federation of Hemophilia 2012;18(3):e316-22.
2012: J H Foley; L Ferris; Kathleen E Brummel-Ziedins
Characteristics of fibrin formation and clot stability in individuals with congenital type IIb protein C deficiency.
Thrombosis research 2012;129(4):e142-6.
2012: J H Foley; Kenneth G Mann; Saulius Butenas; Kathleen E Brummel-Ziedins
Measuring the mechanical properties of blood clots formed via the tissue factor pathway of coagulation.
Analytical biochemistry 2012;422(1):46-51.
2012: M Gissel; Kenneth G Mann; Georges-Etienne Rivard; Matthew F Whelihan; L A Ferris; Kathleen E Brummel-Ziedins
The influence of prophylactic factor VIII in severe haemophilia A.
Haemophilia : the official journal of the World Federation of Hemophilia 2012;18(2):193-9.
2012: Kathleen E Brummel-Ziedins; Peter W Callas; Matthew Gissel; Kenneth G Mann; Thomas Orfeo; Edwin G Bovill
The prothrombotic phenotypes in familial protein C deficiency are differentiated by computational modeling of thrombin generation.
PloS one 2012;7(9):e44378.
2012: Christopher M Danforth; Stephen J Everse; Kenneth G Mann; Thomas Orfeo; Kathleen E Brummel-Ziedins
Defining the boundaries of normal thrombin generation: investigations into hemostasis.
PloS one 2012;7(2):e30385.
2012: Kathleen E Brummel-Ziedins; Matthew Gissel; Kenneth G Mann; Thomas Orfeo; Frits R Rosendaal
Factor Xa generation by computational modeling: an additional discriminator to thrombin generation evaluation.
PloS one 2012;7(1):e29178.
2011: Kathleen E Brummel-Ziedins; G E Rivard; Matthew F Whelihan; Saulius Butenas
Activated protein C inhibitor for correction of thrombin generation in hemophilia A blood and plasma1.
Journal of thrombosis and haemostasis : JTH 2011;9(11):2262-7.
2011: Thomas Orfeo; Anetta Undas; Kathleen E Brummel-Ziedins; Saulius Butenas; Matthew Gissel; Kenneth G Mann
Anticoagulants and the propagation phase of thrombin generation.
PloS one 2011;6(11):e27852.
2011: Beth A Bouchard; Aimee K Paradis; Kathleen E Brummel-Ziedins
Measurement of procoagulant platelet subpopulations in whole blood: development of an assay for population-based studies.
Thrombosis research 2011;127(1):62-4.
2010: James E Campbell; Kathleen E Brummel-Ziedins; Saulius Butenas; Kenneth G Mann
Cellular regulation of blood coagulation: a model for venous stasis.
Blood 2010;116(26):6082-91.
2010: Matthew Gissel; Anetta Undas; Agnieszka Slowik; Kenneth G Mann; Kathleen E Brummel-Ziedins
Plasma factor and inhibitor composition contributes to thrombin generation dynamics in patients with acute or previous cerebrovascular events.
Thrombosis research 2010;126(4):262-9.
2010: Thomas Orfeo; Saulius Butenas; Kathleen E Brummel-Ziedins; M Gissel; Kenneth G Mann
Anticoagulation by factor Xa inhibitors.
Journal of thrombosis and haemostasis : JTH 2010;8(8):1745-53.
2010: Anetta Undas; Zbigniew Siudak; Kathleen E Brummel-Ziedins; Kenneth G Mann; Wieslawa Tracz
Prothrombinase formation at the site of microvascular injury and aspirin resistance: the effect of simvastatin.
Thrombosis research 2010;125(3):283-5.
2009: Christopher M Danforth; Thomas Orfeo; Kenneth G Mann; Kathleen E Brummel-Ziedins; Stephen J Everse
The impact of uncertainty in a blood coagulation model.
Mathematical medicine and biology : a journal of the IMA 2009;26(4):323-36.
2009: Kathleen E Brummel-Ziedins; Matthew F Whelihan; M Gissel; Kenneth G Mann; G E Rivard
Thrombin generation and bleeding in haemophilia A.
Haemophilia : the official journal of the World Federation of Hemophilia 2009;15(5):1118-25.
2009: Kathleen E Brummel-Ziedins; Matthew Gissel; Charles Francis; John Queenan; Kenneth G Mann
The effect of high circulating estradiol levels on thrombin generation during in vitro fertilization.
Thrombosis research 2009;124(4):505-7.
2009: Kathleen E Brummel-Ziedins; Thomas Orfeo; Frits R Rosendaal; Anetta Undas; G E Rivard; Saulius Butenas; Kenneth G Mann
Empirical and theoretical phenotypic discrimination.
Journal of thrombosis and haemostasis : JTH 2009;7 Suppl 1():181-6.
2009: Kathleen E Brummel-Ziedins; R F Branda; Saulius Butenas; Kenneth G Mann
Discordant fibrin formation in hemophilia.
Journal of thrombosis and haemostasis : JTH 2009;7(5):825-32.
2009: Jolanta Krudysz-Amblo; Behnaz Parhami-Seren; Saulius Butenas; Kathleen E Brummel-Ziedins; Edward D Gomperts; Georges E Rivard; Kenneth G Mann
Quantitation of anti-factor VIII antibodies in human plasma.
Blood 2009;113(11):2587-94.
2009: Anetta Undas; Konstanty Szułdrzyński; Kathleen E Brummel-Ziedins; Wieslawa Tracz; Krzysztof Zmudka; Kenneth G Mann
Systemic blood coagulation activation in acute coronary syndromes.
Blood 2009;113(9):2070-8.
2009: Kenneth G Mann; Thomas Orfeo; Saulius Butenas; Anetta Undas; Kathleen E Brummel-Ziedins
Blood coagulation dynamics in haemostasis.
Hämostaseologie 2009;29(1):7-16.
2008: Thomas Orfeo; Kathleen E Brummel-Ziedins; Matthew Gissel; Saulius Butenas; Kenneth G Mann
The nature of the stable blood clot procoagulant activities.
The Journal of biological chemistry 2008;283(15):9776-86.
2008: Kathleen E Brummel-Ziedins; Anetta Undas; Thomas Orfeo; M Gissel; Saulius Butenas; Krzysztof Zmudka; Kenneth G Mann
Thrombin generation in acute coronary syndrome and stable coronary artery disease: dependence on plasma factor composition.
Journal of thrombosis and haemostasis : JTH 2008;6(1):104-10.
2007: Anetta Undas; Beata Brzezinska-Kolarz; Thomas Orfeo; Kathleen E Brummel-Ziedins; Jacek Musial; Andrew Szczeklik; Kenneth G Mann
Blood coagulation at the site of microvascular injury in healthy and coumadin-treated subjects heterogenous for factor V Leiden mutation.
Thrombosis and haemostasis 2007;98(5):1024-30.
2007: Saulius Butenas; Thomas Orfeo; Kathleen E Brummel-Ziedins; Kenneth G Mann
Tissue factor in thrombosis and hemorrhage.
Surgery 2007;142(4 Suppl):S2-14.
2007: Saulius Butenas; Thomas Orfeo; Kathleen E Brummel-Ziedins; Kenneth G Mann
Influence of bivalirudin on tissue factor-triggered coagulation.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2007;18(5):407-14.
2007: Anetta Undas; Kathleen E Brummel-Ziedins; Kenneth G Mann
Antithrombotic properties of aspirin and resistance to aspirin: beyond strictly antiplatelet actions.
Blood 2007;109(6):2285-92.
2006: Kathleen E Brummel-Ziedins; Matthew F Whelihan; Eduards G Ziedins; Kenneth G Mann
The resuscitative fluid you choose may potentiate bleeding.
The Journal of trauma 2006;61(6):1350-8.
2006: Anetta Undas; Kathleen E Brummel-Ziedins; Daniel P Potaczek; B Stobierska-Dzierzek; L Bryniarski; Andrew Szczeklik; Kenneth G Mann
Atorvastatin and quinapril inhibit blood coagulation in patients with coronary artery disease following 28 days of therapy.
Journal of thrombosis and haemostasis : JTH 2006;4(11):2397-404.
2006: Kenneth G Mann; Kathleen E Brummel-Ziedins; Thomas Orfeo; Saulius Butenas
Models of blood coagulation.
Blood cells, molecules & diseases 2006;36(2):108-17.
2005: Thomas Orfeo; Saulius Butenas; Kathleen E Brummel-Ziedins; Kenneth G Mann
The tissue factor requirement in blood coagulation.
The Journal of biological chemistry 2005;280(52):42887-96.
2005: Kathleen E Brummel-Ziedins; Carla Y Vossen; Saulius Butenas; Kenneth G Mann; Frits R Rosendaal
Thrombin generation profiles in deep venous thrombosis.
Journal of thrombosis and haemostasis : JTH 2005;3(11):2497-505.
2005: G E Rivard; Kathleen E Brummel-Ziedins; Kenneth G Mann; L Fan; A Hofer; E Cohen
Evaluation of the profile of thrombin generation during the process of whole blood clotting as assessed by thrombelastography.
Journal of thrombosis and haemostasis : JTH 2005;3(9):2039-43.
2005: Anetta Undas; Beata Brzezinska-Kolarz; Kathleen E Brummel-Ziedins; Jacek Musial; Andrew Szczeklik; Kenneth G Mann
Factor XIII Val34Leu polymorphism and gamma-chain cross-linking at the site of microvascular injury in healthy and coumadin-treated subjects.
Journal of thrombosis and haemostasis : JTH 2005;3(9):2015-21.
2005: Anetta Undas; Magdalena Celinska-Löwenhoff; Kathleen E Brummel-Ziedins; Jan Brozek; Andrew Szczeklik; Kenneth G Mann
Simvastatin given for 3 days can inhibit thrombin generation and activation of factor V and enhance factor Va inactivation in hypercholesterolemic patients.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(7):1524-5.
2005: Kathleen E Brummel-Ziedins; Carla Y Vossen; Frits R Rosendaal; K Umezaki; Kenneth G Mann
The plasma hemostatic proteome: thrombin generation in healthy individuals.
Journal of thrombosis and haemostasis : JTH 2005;3(7):1472-81.
2005: Saulius Butenas; Beth A Bouchard; Kathleen E Brummel-Ziedins; Behnaz Parhami-Seren; Kenneth G Mann
Tissue factor activity in whole blood.
Blood 2005;105(7):2764-70.
2005: Anetta Undas; Kathleen E Brummel-Ziedins; Kenneth G Mann
Statins and blood coagulation.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(2):287-94.
2004: Kathleen E Brummel-Ziedins; G E Rivard; R L Pouliot; Saulius Butenas; M Gissel; Behnaz Parhami-Seren; Kenneth G Mann
Factor VIIa replacement therapy in factor VII deficiency.
Journal of thrombosis and haemostasis : JTH 2004;2(10):1735-44.
2004: Kenneth G Mann; Kathleen E Brummel-Ziedins; Anetta Undas; Saulius Butenas
Does the genotype predict the phenotype? Evaluations of the hemostatic proteome.
Journal of thrombosis and haemostasis : JTH 2004;2(10):1727-34.
2004: Saulius Butenas; Thomas Orfeo; Matthew T Gissel; Kathleen E Brummel-Ziedins; Kenneth G Mann
The significance of circulating factor IXa in blood.
The Journal of biological chemistry 2004;279(22):22875-82.
2004: Kathleen E Brummel-Ziedins; R L Pouliot; Kenneth G Mann
Thrombin generation: phenotypic quantitation.
Journal of thrombosis and haemostasis : JTH 2004;2(2):281-8.
2003: Kenneth G Mann; Kathleen E Brummel-Ziedins; Saulius Butenas
What is all that thrombin for?
Journal of thrombosis and haemostasis : JTH 2003;1(7):1504-14.
2003: Saulius Butenas; Kathleen E Brummel-Ziedins; Beth A Bouchard; Kenneth G Mann
How factor VIIa works in hemophilia.
Journal of thrombosis and haemostasis : JTH 2003;1(6):1158-60.
2003: Anetta Undas; Wojciech J Sydor; Kathleen E Brummel-Ziedins; Jacek Musial; Kenneth G Mann; Andrew Szczeklik
Aspirin alters the cardioprotective effects of the factor XIII Val34Leu polymorphism.
Circulation 2003;107(1):17-20.
2003: Saulius Butenas; Kathleen E Brummel-Ziedins; Sara G Paradis; Kenneth G Mann
Influence of factor VIIa and phospholipids on coagulation in "acquired" hemophilia.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(1):123-9.
2003: Kenneth G Mann; Saulius Butenas; Kathleen E Brummel-Ziedins
The dynamics of thrombin formation.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(1):17-25.
2002: Kathleen E Brummel-Ziedins; Sara G Paradis; Saulius Butenas; Kenneth G Mann
Thrombin functions during tissue factor-induced blood coagulation.
Blood 2002;100(1):148-52.
2002: Saulius Butenas; Kathleen E Brummel-Ziedins; Richard F Branda; Sara G Paradis; Kenneth G Mann
Mechanism of factor VIIa-dependent coagulation in hemophilia blood.
Blood 2002;99(3):923-30.
2001: Anetta Undas; Kathleen E Brummel-Ziedins; Jacek Musial; Kenneth G Mann; Andrew Szczeklik
Pl(A2) polymorphism of beta(3) integrins is associated with enhanced thrombin generation and impaired antithrombotic action of aspirin at the site of microvascular injury.
Circulation 2001;104(22):2666-72.
2001: Kathleen E Brummel-Ziedins; Sara G Paradis; Richard F Branda; Kenneth G Mann
Oral anticoagulation thresholds.
Circulation 2001;104(19):2311-7.
2001: Anetta Undas; Kathleen E Brummel-Ziedins; Jacek Musial; Kenneth G Mann; Andrew Szczeklik
Blood coagulation at the site of microvascular injury: effects of low-dose aspirin.
Blood 2001;98(8):2423-31.
2001: Anetta Undas; Kathleen E Brummel-Ziedins; Jacek Musial; Kenneth G Mann; Andrew Szczeklik
Simvastatin depresses blood clotting by inhibiting activation of prothrombin, factor V, and factor XIII and by enhancing factor Va inactivation.
Circulation 2001;103(18):2248-53.
2000: Saulius Butenas; C van 't Veer; Kevin Cawthern; Kathleen E Brummel-Ziedins; Kenneth G Mann
Models of blood coagulation.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2000;11 Suppl 1():S9-13.
1999: Kathleen E Brummel-Ziedins; Saulius Butenas; Kenneth G Mann
An integrated study of fibrinogen during blood coagulation.
The Journal of biological chemistry 1999;274(32):22862-70.