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Manu Lopus

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Manu Lopus; Cristina Manatschal; Herbert P Miller; Michel O Steinmetz; Saša Bjelić; Ruben M Buey; Leslie Wilson
Cooperative stabilization of microtubule dynamics by EB1 and CLIP-170 involves displacement of stably bound P(i) at microtubule ends.
Pradeep K Naik; Surya N Vangapandu; Ritu Aneja; Manu Lopus; Harish C Joshi
In silico inspired design and synthesis of a novel tubulin-binding anti-cancer drug: folate conjugated noscapine (Targetin).
V Pannu; Padmashree C G Rida; Jun Zhou; A Cheng; Robert Clewley; P Karna; Manu Lopus; R C Mishra; A Ogden; Ritu Aneja
Induction of robust de novo centrosome amplification, high-grade spindle multipolarity and metaphase catastrophe: a novel chemotherapeutic approach.

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All Publications

2012: Manu Lopus; Cristina Manatschal; Herbert P Miller; Michel O Steinmetz; Saša Bjelić; Ruben M Buey; Leslie Wilson
Cooperative stabilization of microtubule dynamics by EB1 and CLIP-170 involves displacement of stably bound P(i) at microtubule ends.
Biochemistry 2012;51(14):3021-30.
2012: Pradeep K Naik; Surya N Vangapandu; Ritu Aneja; Manu Lopus; Harish C Joshi
In silico inspired design and synthesis of a novel tubulin-binding anti-cancer drug: folate conjugated noscapine (Targetin).
Journal of computer-aided molecular design 2012;26(2):233-47.
2012: V Pannu; Padmashree C G Rida; Jun Zhou; A Cheng; Robert Clewley; P Karna; Manu Lopus; R C Mishra; A Ogden; Ritu Aneja
Induction of robust de novo centrosome amplification, high-grade spindle multipolarity and metaphase catastrophe: a novel chemotherapeutic approach.
Cell death & disease 2012;3():e346.
2011: Peter Hinow; Mary Ann Jordan; Manu Lopus; Vahid Rezania; Jack A Tuszyński
Modeling the effects of drug binding on the dynamic instability of microtubules.
Physical biology 2011;8(5):056004.
2011: Manu Lopus
Antibody-DM1 conjugates as cancer therapeutics.
Cancer letters 2011;307(2):113-8.
2011: Ram Chandra Mishra; Prasanthi Karna; Sushma Reddy Gundala; Vaishali Pannu; Richard A Stanton; Kamlesh Kumar Gupta; M Hope Robinson; Manu Lopus; Leslie Wilson; Maged Henary; Ritu Aneja
Second generation benzofuranone ring substituted noscapine analogs: synthesis and biological evaluation.
Biochemical pharmacology 2011;82(2):110-21.
2011: Rahul H Davé; Witchuda Saengsawang; Manu Lopus; Sonya Davé; Leslie Wilson; Mark M Rasenick
A molecular and structural mechanism for G protein-mediated microtubule destabilization.
The Journal of biological chemistry 2011;286(6):4319-28.
2010: Emin Oroudjev; Manu Lopus; Leslie Wilson; Charlene Audette; Carmela Provenzano; Hans Erickson; Yelena Kovtun; Ravi Chari; Mary Ann Jordan
Maytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability.
Molecular cancer therapeutics 2010;9(10):2700-13.
2010: Manu Lopus; Emin Oroudjev; Leslie Wilson; Sharon Wilhelm; Wayne Widdison; Ravi Chari; Mary Ann Jordan
Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules.
Molecular cancer therapeutics 2010;9(10):2689-99.
2010: Mythili Yenjerla; Manu Lopus; Leslie Wilson
Analysis of dynamic instability of steady-state microtubules in vitro by video-enhanced differential interference contrast microscopy with an appendix by Emin Oroudjev.
Methods in cell biology 2010;95():189-206.
2010: Mythili Yenjerla; Nichole E LaPointe; Manu Lopus; Corey Cox; Mary Ann Jordan; Stuart C Feinstein; Leslie Wilson
The neuroprotective peptide NAP does not directly affect polymerization or dynamics of reconstituted neural microtubules.
Journal of Alzheimer's disease : JAD 2010;19(4):1377-86.
2006: Ritu Aneja; Surya N Vangapandu; Manu Lopus; Vijaya G Viswesarappa; Neerupma Dhiman; Akhilesh Verma; Ramesh Chandra; Dulal Panda; Harish C Joshi
Synthesis of microtubule-interfering halogenated noscapine analogs that perturb mitosis in cancer cells followed by cell death.
Biochemical pharmacology 2006;72(4):415-26.
2006: Ritu Aneja; Surya N Vangapandu; Manu Lopus; Ramesh Chandra; Dulal Panda; Harish C Joshi
Development of a novel nitro-derivative of noscapine for the potential treatment of drug-resistant ovarian cancer and T-cell lymphoma.
Molecular pharmacology 2006;69(6):1801-9.
2006: Manu Lopus; Dulal Panda
The benzophenanthridine alkaloid sanguinarine perturbs microtubule assembly dynamics through tubulin binding. A possible mechanism for its antiproliferative activity.
The FEBS journal 2006;273(10):2139-50.
2006: Ritu Aneja; Manu Lopus; Jun Zhou; Surya N Vangapandu; Amr M Ghaleb; Joyce Yao; James Nettles; Binfei Zhou; Meenakshi Gupta; Dulal Panda; Ramesh Chandra; Harish C Joshi
Rational design of the microtubule-targeting anti-breast cancer drug EM015.
Cancer research 2006;66(7):3782-91.