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Thomas Cech

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Andrew B Dalby; Karen J Goodrich; Jennifer S Pfingsten; Thomas R Cech
RNA recognition by the DNA end-binding Ku heterodimer.
Jayakrishnan Nandakumar; Thomas R Cech
Finding the end: recruitment of telomerase to telomeres.
Thomas R Cech
How a chemist looks at RNA.

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All Publications

2013: Andrew B Dalby; Karen J Goodrich; Jennifer S Pfingsten; Thomas R Cech
RNA recognition by the DNA end-binding Ku heterodimer.
RNA (New York, N.Y.) 2013;19(6):841-51.
2013: Jayakrishnan Nandakumar; Thomas R Cech
Finding the end: recruitment of telomerase to telomeres.
Nature reviews. Molecular cell biology 2013;14(2):69-82.
2013: Thomas R Cech
How a chemist looks at RNA.
Angewandte Chemie (International ed. in English) 2013;52(1):75-8.
2012: Jayakrishnan Nandakumar; Ina Weidenfeld; Arthur J Zaug; Caitlin F Bell; Leslie A Leinwand; Thomas R Cech
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
Nature 2012;492(7428):285-9.
2012: Andrea J Berman; Thomas R Cech
SnapShot: telomeres and telomerase.
Cell 2012;151(5):1138-1138.e1.
2012: Thomas R Cech
The RNA worlds in context.
Cold Spring Harbor perspectives in biology 2012;4(7):a006742.
2012: Katherine C Goldfarb; Sumit Borah; Thomas R Cech
RNase P branches out from RNP to protein: organelle-triggered diversification?
Genes & development 2012;26(10):1005-9.
2012: Jennifer S Pfingsten; Cornelius Taabazuing; Pascal Chartrand; Karen J Goodrich; Faissal Ouenzar; Thomas R Cech
Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model.
Cell 2012;148(5):922-32.
2011: Andrea J Berman; Benjamin M Akiyama; Michael D Stone; Thomas R Cech
The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis.
Nature structural & molecular biology 2011;18(12):1371-5.
2011: Derek J Taylor; Elaine R Podell; Dylan J Taatjes; Thomas R Cech
Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA.
Journal of molecular biology 2011;410(1):10-7.
2011: Luis F Z Batista; Thomas R Cech; Athena M Cherry; Jinkuk Choi; Sharon M Crary; Neelam Giri; Ha Nam Nguyen; Matthew F Pech; Renee A Reijo Pera; Sharon A Savage; Vittorio Sebastiano; Marius Wernig; Kathleen T Xie; Arthur J Zaug; Franklin L Zhong; BLANCHE ALTER; Steven E Artandi
Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells.
Nature 2011;474(7351):399-402.
2010: Andrea J Berman; Anne R Gooding; Thomas R Cech
Tetrahymena telomerase protein p65 induces conformational changes throughout telomerase RNA (TER) and rescues telomerase reverse transcriptase and TER assembly mutants.
Molecular and cellular biology 2010;30(20):4965-76.
2010: Feng Qiao; Karen J Goodrich; Thomas R Cech
Engineering cis-telomerase RNAs that add telomeric repeats to themselves.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(11):4914-8.
2010: Arthur J Zaug; Elaine R Podell; Jayakrishnan Nandakumar; Thomas R Cech
Functional interaction between telomere protein TPP1 and telomerase.
Genes & development 2010;24(6):613-22.
2010: Chrysa M Latrick; Thomas R Cech
POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation.
The EMBO journal 2010;29(5):924-33.
2010: Jayakrishnan Nandakumar; Elaine R Podell; Thomas R Cech
How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(2):651-6.
2009: Thomas R Cech
Crawling out of the RNA world.
Cell 2009;136(4):599-602.
2009: Quentin Vicens; Thomas R Cech
A natural ribozyme with 3',5' RNA ligase activity.
Nature chemical biology 2009;5(2):97-9.
2009: David C Zappulla; Jennifer N Roberts; Karen J Goodrich; Thomas R Cech; Deborah S Wuttke
Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p.
Nucleic acids research 2009;37(2):354-67.
2009: Thomas R Cech
Evolution of biological catalysis: ribozyme to RNP enzyme.
Cold Spring Harbor symposia on quantitative biology 2009;74():11-6.
2008: Quentin Vicens; Paul J Paukstelis; Eric Westhof; Alan M Lambowitz; Thomas R Cech
Toward predicting self-splicing and protein-facilitated splicing of group I introns.
RNA (New York, N.Y.) 2008;14(10):2013-29.
2008: Arthur J Zaug; Elaine R Podell; Thomas R Cech
Mutation in TERT separates processivity from anchor-site function.
Nature structural & molecular biology 2008;15(8):870-2.
2008: Feng Qiao; Thomas R Cech
Triple-helix structure in telomerase RNA contributes to catalysis.
Nature structural & molecular biology 2008;15(6):634-40.
2008: Amy D Mozdy; Elaine R Podell; Thomas R Cech
Multiple yeast genes, including Paf1 complex genes, affect telomere length via telomerase RNA abundance.
Molecular and cellular biology 2008;28(12):4152-61.
2007: Ken-ichi Arai; Thomas R Cech; Jean-Lou Chameau; Paul Horn; Iain W Mattaj; Janez Potocnik; John Wiley
The future of research universities. Is the model of research-intensive universities still valid at the beginning of the twenty-first century?
EMBO reports 2007;8(9):804-10.
2007: Thomas R Cech; Jack Dixon; Avice Meehan; Josephine Briggs; Carl Rhodes
A reply from HHMI.
The Journal of experimental medicine 2007;204(8):1731; author reply 1731.
2007: Thomas R Cech; Jack Dixon; Avice Meehan; Josephine Briggs; Carl Rhodes
A reply from Howard Hughes Medical Institute (HHMI).
The Journal of cell biology 2007;178(3):343; discussion 343.
2007: Thomas R Cech
On the occasion of the 25th anniversary of the discovery of catalytic RNA.
Biological chemistry 2007;388(7):661-2.
2007: Quentin Vicens; Anne R Gooding; Alain Laederach; Thomas R Cech
Local RNA structural changes induced by crystallization are revealed by SHAPE.
RNA (New York, N.Y.) 2007;13(4):536-48.
2007: Feng Wang; Elaine R Podell; Arthur J Zaug; Yuting Yang; Paul Baciu; Thomas R Cech; Ming Lei
The POT1-TPP1 telomere complex is a telomerase processivity factor.
Nature 2007;445(7127):506-10.
2006: Amy D Mozdy; Thomas R Cech
Low abundance of telomerase in yeast: implications for telomerase haploinsufficiency.
RNA (New York, N.Y.) 2006;12(9):1721-37.
2006: Steven Jacobs; Elaine R Podell; Thomas R Cech
Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.
Nature structural & molecular biology 2006;13(3):218-25.
2006: Feng Guo; Anne R Gooding; Thomas R Cech
Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme.
RNA (New York, N.Y.) 2006;12(3):387-95.
2006: David C Zappulla; Thomas R Cech
RNA as a flexible scaffold for proteins: yeast telomerase and beyond.
Cold Spring Harbor symposia on quantitative biology 2006;71():217-24.
2006: Quentin Vicens; Thomas R Cech
Atomic level architecture of group I introns revealed.
Trends in biochemical sciences 2006;31(1):41-51.
2005: Thomas R Cech; Donald Kennedy
Doing more for Kate.
Science (New York, N.Y.) 2005;310(5755):1741.
2005: Thomas R Cech
Meeting a fork in the road: an interview with Tom Cech. Interview by Jane Gitschier.
PLoS genetics 2005;1(6):e76.
2005: David C Zappulla; Karen Goodrich; Thomas R Cech
A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro.
Nature structural & molecular biology 2005;12(12):1072-7.
2005: Thomas R Cech
Fostering innovation and discovery in biomedical research.
JAMA : the journal of the American Medical Association 2005;294(11):1390-3.
2005: Patricia L Opresko; Penelope A Mason; Elaine R Podell; Ming Lei; Ian D Hickson; Thomas R Cech; Vilhelm A Bohr
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates.
The Journal of biological chemistry 2005;280(37):32069-80.
2005: Arthur J Zaug; Elaine R Podell; Thomas R Cech
Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(31):10864-9.
2005: Steven Jacobs; Elaine R Podell; Deborah S Wuttke; Thomas R Cech
Soluble domains of telomerase reverse transcriptase identified by high-throughput screening.
Protein science : a publication of the Protein Society 2005;14(8):2051-8.
2005: Ming Lei; Arthur J Zaug; Elaine R Podell; Thomas R Cech
Switching human telomerase on and off with hPOT1 protein in vitro.
The Journal of biological chemistry 2005;280(21):20449-56.
2005: Jeffrey G Mandell; Karen J Goodrich; Jürg Bähler; Thomas R Cech
Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase.
The Journal of biological chemistry 2005;280(7):5249-57.
2005: Jeffrey G Mandell; Jürg Bähler; Thomas A Volpe; Robert A Martienssen; Thomas R Cech
Global expression changes resulting from loss of telomeric DNA in fission yeast.
Genome biology 2005;6(1):R1.
2004: Thomas R Cech; Gerald M Rubin
Nurturing interdisciplinary research.
Nature structural & molecular biology 2004;11(12):1166-9.
2004: Ming Lei; Elaine R Podell; Thomas R Cech
Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection.
Nature structural & molecular biology 2004;11(12):1223-9.
2004: Feng Guo; Anne R Gooding; Thomas R Cech
Structure of the Tetrahymena ribozyme: base triple sandwich and metal ion at the active site.
Molecular cell 2004;16(3):351-62.
2004: Thomas R Cech
Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena.
Bioscience reports 2004;24(4-5):362-85.
2004: David C Zappulla; Thomas R Cech
Yeast telomerase RNA: a flexible scaffold for protein subunits.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(27):10024-9.
2004: Stefan Aigner; Thomas R Cech
The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro.
RNA (New York, N.Y.) 2004;10(7):1108-18.
2004: Thomas R Cech; Enriqueta Bond
Managing your own lab.
Science (New York, N.Y.) 2004;304(5678):1717.
2004: Thomas R Cech
RNA finds a simpler way.
Nature 2004;428(6980):263-4.
2004: Thomas R Cech
Beginning to understand the end of the chromosome.
Cell 2004;116(2):273-9.
2003: Tracy M Bryan; Karen J Goodrich; Thomas R Cech
Tetrahymena telomerase is active as a monomer.
Molecular biology of the cell 2003;14(12):4794-804.
2003: Ming Lei; Elaine R Podell; Peter Baumann; Thomas R Cech
DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA.
Nature 2003;426(6963):198-203.
2003: Anita G Seto; Kfir Umansky; Yehuda Tzfati; Arthur J Zaug; Elizabeth H Blackburn; Thomas R Cech
A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity.
RNA (New York, N.Y.) 2003;9(11):1323-32.
2003: Scott Classen; Dan Lyons; Thomas R Cech; Steve C Schultz
Sequence-specific and 3'-end selective single-strand DNA binding by the Oxytricha nova telomere end binding protein alpha subunit.
Biochemistry 2003;42(31):9269-77.
2003: Lorel M Colgin; Katherine Baran; Peter Baumann; Thomas R Cech; Roger R Reddel
Human POT1 facilitates telomere elongation by telomerase.
Current biology : CB 2003;13(11):942-6.
2003: Stefan Aigner; Jan Postberg; Hans J Lipps; Thomas R Cech
The Euplotes La motif protein p43 has properties of a telomerase-specific subunit.
Biochemistry 2003;42(19):5736-47.
2003: Thomas R Cech; Sean R Eddy; David Eisenberg; Karen Hersey; Steven H Holtzman; George H Poste; Natasha V Raikhel; Richard H Scheller; David B Singer; Mary C Waltham
Sharing publication-related data and materials: responsibilities of authorship in the life sciences.
Plant physiology 2003;132(1):19-24.
2003: Klaus Förstemann; Arthur J Zaug; Thomas R Cech; Joachim Lingner
Yeast telomerase is specialized for C/A-rich RNA templates.
Nucleic acids research 2003;31(6):1646-55.
2003: Thomas R Cech
Rebalancing teaching and research.
Science (New York, N.Y.) 2003;299(5604):165.
2003: Katherine L Friedman; Jeremy J Heit; David M Long; Thomas R Cech
N-terminal domain of yeast telomerase reverse transcriptase: recruitment of Est3p to the telomerase complex.
Molecular biology of the cell 2003;14(1):1-13.
2002: Ming Lei; Peter Baumann; Thomas R Cech
Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe.
Biochemistry 2002;41(49):14560-8.
2002: Thomas R Cech
Ribozymes, the first 20 years.
Biochemical Society transactions 2002;30(Pt 6):1162-6.
2002: Anita G Seto; April J Livengood; Yehuda Tzfati; Elizabeth H Blackburn; Thomas R Cech
A bulged stem tethers Est1p to telomerase RNA in budding yeast.
Genes & development 2002;16(21):2800-12.
2002: Peter Baumann; Elaine R Podell; Thomas R Cech
Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing.
Molecular and cellular biology 2002;22(22):8079-87.
2002: Feng Guo; Thomas R Cech
Evolution of Tetrahymena ribozyme mutants with increased structural stability.
Nature structural biology 2002;9(11):855-61.
2002: Jennifer A Doudna; Thomas R Cech
The chemical repertoire of natural ribozymes.
Nature 2002;418(6894):222-8.
2002: Feng Guo; Thomas R Cech
In vivo selection of better self-splicing introns in Escherichia coli: the role of the P1 extension helix of the Tetrahymena intron.
RNA (New York, N.Y.) 2002;8(5):647-58.
2002: April J Livengood; Arthur J Zaug; Thomas R Cech
Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction.
Molecular and cellular biology 2002;22(7):2366-74.
2002: Michael B Jarstfer; Thomas R Cech
Effects of nucleotide analogues on Euplotes aediculatus telomerase processivity: evidence for product-assisted translocation.
Biochemistry 2002;41(1):151-61.
2002: Thomas R Cech
HHMI's attention to Wiley's lab staff.
Science (New York, N.Y.) 2002;295(5552):43.
2001: Thomas R Cech
Funding above and beyond scientific research. An interview with Thomas R. Cech, President of the Howard Hughes Medical Institute in Chevy Chase, MD. Interviewed by Holger Breithaupt.
EMBO reports 2001;2(9):751-4.
2001: Thomas R Cech; L W Egan; C Doyle; E Gallin; M A Lichtman; C J Queenan; N Sung
The biomedical research bottleneck.
Science (New York, N.Y.) 2001;293(5530):573.
2001: J M Sperger; Thomas R Cech
A stem-loop of Tetrahymena telomerase RNA distant from the template potentiates RNA folding and telomerase activity.
Biochemistry 2001;40(24):7005-16.
2001: Peter Baumann; Thomas R Cech
Pot1, the putative telomere end-binding protein in fission yeast and humans.
Science (New York, N.Y.) 2001;292(5519):1171-5.
2001: S B Cohen; Thomas R Cech
Engineering disulfide cross-links in RNA using thiol-disulfide interchange chemistry.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2001;Chapter 5():Unit 5.1.
2001: K Juneau; Elaine R Podell; D J Harrington; Thomas R Cech
Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA--solvent interactions.
Structure (London, England : 1993) 2001;9(3):221-31.
2001: Thomas R Cech; J S Leonard
Science and business. Conflicts of interest--moving beyond disclosure.
Science (New York, N.Y.) 2001;291(5506):989.
2001: SK Silverman; Thomas R Cech
An early transition state for folding of the P4-P6 RNA domain.
RNA (New York, N.Y.) 2001;7(2):161-6.
2000: Stefan Aigner; J Lingner; K J Goodrich; C A Grosshans; A Shevchenko; M Mann; Thomas R Cech
Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting.
The EMBO journal 2000;19(22):6230-9.
2000: SK Silverman; Michael Deras; Sarah A Woodson; S A Scaringe; Thomas R Cech
Multiple folding pathways for the P4-P6 RNA domain.
Biochemistry 2000;39(40):12465-75.
2000: P Baumann; Thomas R Cech
Protection of telomeres by the Ku protein in fission yeast.
Molecular biology of the cell 2000;11(10):3265-75.
2000: Thomas R Cech
Structural biology. The ribosome is a ribozyme.
Science (New York, N.Y.) 2000;289(5481):878-9.
2000: Tracy M Bryan; Karen J Goodrich; Thomas R Cech
A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity.
The Journal of biological chemistry 2000;275(31):24199-207.
2000: Tracy M Bryan; Karen J Goodrich; Thomas R Cech
Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase.
Molecular cell 2000;6(2):493-9.
2000: C H Haering; Toru Nakamura; P Baumann; Thomas R Cech
Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomycespombe.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6367-72.
1999: SK Silverman; M Zheng; M Wu; Ignacio Tinoco; Thomas R Cech
Quantifying the energetic interplay of RNA tertiary and secondary structure interactions.
RNA (New York, N.Y.) 1999;5(12):1665-74.
1999: M Hagen; Thomas R Cech
Self-splicing of the Tetrahymena intron from mRNA in mammalian cells.
The EMBO journal 1999;18(22):6491-500.
1999: Katherine L Friedman; Thomas R Cech
Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants.
Genes & development 1999;13(21):2863-74.
1999: SK Silverman; Thomas R Cech
RNA tertiary folding monitored by fluorescence of covalently attached pyrene.
Biochemistry 1999;38(43):14224-37.
1999: Anita G Seto; Arthur J Zaug; SG Sobel; Sandra L Wolin; Thomas R Cech
Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle.
Nature 1999;401(6749):177-80.
1999: K Juneau; Thomas R Cech
In vitro selection of RNAs with increased tertiary structure stability.
RNA (New York, N.Y.) 1999;5(8):1119-29.
1999: SK Silverman; Thomas R Cech
Energetics and cooperativity of tertiary hydrogen bonds in RNA structure.
Biochemistry 1999;38(27):8691-702.
1999: T M Bryan; Thomas R Cech
Telomerase and the maintenance of chromosome ends.
Current opinion in cell biology 1999;11(3):318-24.
1998: E Jabri; Thomas R Cech
In vitro selection of the Naegleria GIR1 ribozyme identifies three base changes that dramatically improve activity.
RNA (New York, N.Y.) 1998;4(12):1481-92.
1998: Toru Nakamura; J P Cooper; Thomas R Cech
Two modes of survival of fission yeast without telomerase.
Science (New York, N.Y.) 1998;282(5388):493-6.
1998: Barbara L Golden; Anne R Gooding; Elaine R Podell; Thomas R Cech
A preorganized active site in the crystal structure of the Tetrahymena ribozyme.
Science (New York, N.Y.) 1998;282(5387):259-64.
1998: B Zhang; Thomas R Cech
Peptidyl-transferase ribozymes: trans reactions, structural characterization and ribosomal RNA-like features.
Chemistry & biology 1998;5(10):539-53.
1998: S B Cohen; Thomas R Cech
A quantitative study of the flexibility contributed to RNA structures by nicks and single-stranded gaps.
RNA (New York, N.Y.) 1998;4(10):1179-85.
1998: A A Szewczak; Elaine R Podell; P C Bevilacqua; Thomas R Cech
Thermodynamic stability of the P4-P6 domain RNA tertiary structure measured by temperature gradient gel electrophoresis.
Biochemistry 1998;37(32):11162-70.
1998: Tracy M Bryan; J M Sperger; K B Chapman; Thomas R Cech
Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8479-84.
1998: S J Froelich-Ammon; B A Dickinson; J M Bevilacqua; Steve C Schultz; Thomas R Cech
Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha.
Genes & development 1998;12(10):1504-14.
1998: P C Bevilacqua; Cyril X George; Charles E Samuel; Thomas R Cech
Binding of the protein kinase PKR to RNAs with secondary structure defects: role of the tandem A-G mismatch and noncontiguous helixes.
Biochemistry 1998;37(18):6303-16.
1998: PW Hammond; Thomas R Cech
Euplotes telomerase: evidence for limited base-pairing during primer elongation and dGTP as an effector of translocation.
Biochemistry 1998;37(15):5162-72.
1998: Joachim Lingner; Thomas R Cech
Telomerase and chromosome end maintenance.
Current opinion in genetics & development 1998;8(2):226-32.
1998: Toru Nakamura; Thomas R Cech
Reversing time: origin of telomerase.
Cell 1998;92(5):587-90.
1997: E Jabri; Stefan Aigner; Thomas R Cech
Kinetic and secondary structure analysis of Naegleria andersoni GIR1, a group I ribozyme whose putative biological function is site-specific hydrolysis.
Biochemistry 1997;36(51):16345-54.
1997: B Zhang; Thomas R Cech
Peptide bond formation by in vitro selected ribozymes.
Nature 1997;390(6655):96-100.
1997: Thomas R Cech; Toru Nakamura; J Lingner
Telomerase is a true reverse transcriptase. A review.
Biochemistry. Biokhimii͡a 1997;62(11):1202-5.
1997: C Chapon; Thomas R Cech; Arthur J Zaug
Polyadenylation of telomerase RNA in budding yeast.
RNA (New York, N.Y.) 1997;3(11):1337-51.
1997: J Lingner; Thomas R Cech; T R Hughes; V Lundblad
Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11190-5.
1997: PW Hammond; Thomas R Cech
dGTP-dependent processivity and possible template switching of euplotes telomerase.
Nucleic acids research 1997;25(18):3698-704.
1997: M A Tanner; Emily M Anderson; Robin Gutell; Thomas R Cech
Mutagenesis and comparative sequence analysis of a base triple joining the two domains of group I ribozymes.
RNA (New York, N.Y.) 1997;3(9):1037-51.
1997: L B Weinstein; B C Jones; R Cosstick; Thomas R Cech
A second catalytic metal ion in group I ribozyme.
Nature 1997;388(6644):805-8.
1997: Toru Nakamura; Gregg B Morin; K B Chapman; S L Weinrich; W H Andrews; J Lingner; Calvin B Harley; Thomas R Cech
Telomerase catalytic subunit homologs from fission yeast and human.
Science (New York, N.Y.) 1997;277(5328):955-9.
1997: A A Szewczak; Thomas R Cech
An RNA internal loop acts as a hinge to facilitate ribozyme folding and catalysis.
RNA (New York, N.Y.) 1997;3(8):838-49.
1997: Barbara L Golden; Elaine R Podell; Anne R Gooding; Thomas R Cech
Crystals by design: a strategy for crystallization of a ribozyme derived from the Tetrahymena group I intron.
Journal of molecular biology 1997;270(5):711-23.
1997: T S McConnell; D Herschlag; Thomas R Cech
Effects of divalent metal ions on individual steps of the Tetrahymena ribozyme reaction.
Biochemistry 1997;36(27):8293-303.
1997: J Lingner; T R Hughes; A Shevchenko; Matthias Mann; V Lundblad; Thomas R Cech
Reverse transcriptase motifs in the catalytic subunit of telomerase.
Science (New York, N.Y.) 1997;276(5312):561-7.
1997: J P Cooper; Elaine R Nimmo; Robin C Allshire; Thomas R Cech
Regulation of telomere length and function by a Myb-domain protein in fission yeast.
Nature 1997;385(6618):744-7.
1997: M A Tanner; Thomas R Cech
Joining the two domains of a group I ribozyme to form the catalytic core.
Science (New York, N.Y.) 1997;275(5301):847-9.
1997: Thomas R Cech; J Lingner
Telomerase and the chromosome end replication problem.
Ciba Foundation symposium 1997;211():20-8; discussion 28-34.
1997: PW Hammond; T N Lively; Thomas R Cech
The anchor site of telomerase from Euplotes aediculatus revealed by photo-cross-linking to single- and double-stranded DNA primers.
Molecular and cellular biology 1997;17(1):296-308.
1996: Barbara L Golden; Anne R Gooding; Elaine R Podell; Thomas R Cech
X-ray crystallography of large RNAs: heavy-atom derivatives by RNA engineering.
RNA (New York, N.Y.) 1996;2(12):1295-305.
1996: C P Rusconi; Thomas R Cech
The anticodon is the signal sequence for mitochondrial import of glutamine tRNA in Tetrahymena.
Genes & development 1996;10(22):2870-80.
1996: L Y Kuo; Thomas R Cech
Conserved thermochemistry of guanosine nucleophile binding for structurally distinct group I ribozymes.
Nucleic acids research 1996;24(19):3722-7.
1996: J Lingner; Thomas R Cech
Purification of telomerase from Euplotes aediculatus: requirement of a primer 3' overhang.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):10712-7.
1996: Jamie H Doudna Cate; Anne R Gooding; Elaine R Podell; Kaihong Zhou; Barbara L Golden; Alexander A Szewczak; C E Kundrot; Thomas R Cech; Jennifer A Doudna
RNA tertiary structure mediation by adenosine platforms.
Science (New York, N.Y.) 1996;273(5282):1696-9.
1996: Jamie H Doudna Cate; Anne R Gooding; Elaine R Podell; Kaihong Zhou; Barbara L Golden; C E Kundrot; Thomas R Cech; Jennifer A Doudna
Crystal structure of a group I ribozyme domain: principles of RNA packing.
Science (New York, N.Y.) 1996;273(5282):1678-85.
1996: T B Campbell; Thomas R Cech
Mutations in the Tetrahymena ribozyme internal guide sequence: effects on docking of the P1 helix into the catalytic core and correlation with catalytic activity.
Biochemistry 1996;35(35):11493-502.
1996: P C Bevilacqua; Thomas R Cech
Minor-groove recognition of double-stranded RNA by the double-stranded RNA-binding domain from the RNA-activated protein kinase PKR.
Biochemistry 1996;35(31):9983-94.
1996: W D Downs; Thomas R Cech
Kinetic pathway for folding of the Tetrahymena ribozyme revealed by three UV-inducible crosslinks.
RNA (New York, N.Y.) 1996;2(7):718-32.
1996: Thomas R Cech; A A Szewczak
Selecting apt RNAs for NMR.
RNA (New York, N.Y.) 1996;2(7):625-7.
1996: C P Rusconi; Thomas R Cech
Mitochondrial import of only one of three nuclear-encoded glutamine tRNAs in Tetrahymena thermophila.
The EMBO journal 1996;15(13):3286-95.
1996: Barbara L Golden; Thomas R Cech
Conformational switches involved in orchestrating the successive steps of group I RNA splicing.
Biochemistry 1996;35(12):3754-63.
1996: A J Zaug; J Linger; Thomas R Cech
Method for determining RNA 3' ends and application to human telomerase RNA.
Nucleic acids research 1996;24(3):532-3.
1996: Scott A Strobel; Thomas R Cech
Exocyclic amine of the conserved G.U pair at the cleavage site of the Tetrahymena ribozyme contributes to 5'-splice site selection and transition state stabilization.
Biochemistry 1996;35(4):1201-11.
1996: K M Weeks; Thomas R Cech
Assembly of a ribonucleoprotein catalyst by tertiary structure capture.
Science (New York, N.Y.) 1996;271(5247):345-8.
1996: M Tanner; Thomas R Cech
Activity and thermostability of the small self-splicing group I intron in the pre-tRNA(lle) of the purple bacterium Azoarcus.
RNA (New York, N.Y.) 1996;2(1):74-83.
1995: Toru Nakamura; Y H Wang; A J Zaug; Jack D Griffith; Thomas R Cech
Relative orientation of RNA helices in a group 1 ribozyme determined by helix extension electron microscopy.
The EMBO journal 1995;14(19):4849-59.
1995: J Lingner; J P Cooper; Thomas R Cech
Telomerase and DNA end replication: no longer a lagging strand problem?
Science (New York, N.Y.) 1995;269(5230):1533-4.
1995: T B Campbell; Thomas R Cech
Identification of ribozymes within a ribozyme library that efficiently cleave a long substrate RNA.
RNA (New York, N.Y.) 1995;1(6):598-609.
1995: K M Weeks; Thomas R Cech
Protein facilitation of group I intron splicing by assembly of the catalytic core and the 5' splice site domain.
Cell 1995;82(2):221-30.
1995: Guowei Fang; Thomas R Cech
Telomerase RNA localized in the replication band and spherical subnuclear organelles in hypotrichous ciliates.
The Journal of cell biology 1995;130(2):243-53.
1995: K M Weeks; Thomas R Cech
Efficient protein-facilitated splicing of the yeast mitochondrial bI5 intron.
Biochemistry 1995;34(23):7728-38.
1995: B Hicke; R Rempel; J Maller; R A Swank; J R Hamaguchi; E M Bradbury; David M Prescott; Thomas R Cech
Phosphorylation of the Oxytricha telomere protein: possible cell cycle regulation.
Nucleic acids research 1995;23(11):1887-93.
1995: A J Zaug; Thomas R Cech
Analysis of the structure of Tetrahymena nuclear RNAs in vivo: telomerase RNA, the self-splicing rRNA intron, and U2 snRNA.
RNA (New York, N.Y.) 1995;1(4):363-74.
1995: M A Tanner; Thomas R Cech
An important RNA tertiary interaction of group I and group II introns is implicated in gram-positive RNase P RNAs.
RNA (New York, N.Y.) 1995;1(4):349-50.
1995: Thomas R Cech
Group I introns: new molecular mechanisms for mRNA repair.
Bio/technology (Nature Publishing Company) 1995;13(4):323-6.
1995: T S McConnell; Thomas R Cech
A positive entropy change for guanosine binding and for the chemical step in the Tetrahymena ribozyme reaction.
Biochemistry 1995;34(12):4056-67.
1995: Jennifer A Doudna; Thomas R Cech; B A Sullenger
Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(6):2355-9.
1995: Jennifer A Doudna; Thomas R Cech
Self-assembly of a group I intron active site from its component tertiary structural domains.
RNA (New York, N.Y.) 1995;1(1):36-45.
1995: Scott A Strobel; Thomas R Cech
Minor groove recognition of the conserved G.U pair at the Tetrahymena ribozyme reaction site.
Science (New York, N.Y.) 1995;267(5198):675-9.
1994: A J Zaug; J A Dávila-Aponte; Thomas R Cech
Catalysis of RNA cleavage by a ribozyme derived from the group I intron of Anabaena pre-tRNA(Leu).
Biochemistry 1994;33(49):14935-47.
1994: A M Pyle; S Moran; Scott A Strobel; T Chapman; D H Turner; Thomas R Cech
Replacement of the conserved G.U with a G-C pair at the cleavage site of the Tetrahymena ribozyme decreases binding, reactivity, and fidelity.
Biochemistry 1994;33(46):13856-63.
1994: Scott A Strobel; Thomas R Cech; N Usman; Leonid Beigelman
The 2,6-diaminopurine riboside.5-methylisocytidine wobble base pair: an isoenergetic substitution for the study of G.U pairs in RNA.
Biochemistry 1994;33(46):13824-35.
1994: Thomas R Cech; O C Uhlenbeck
Ribozymes. Hammerhead nailed down.
Nature 1994;372(6501):39-40.
1994: Thomas R Cech
Chromosome end games.
Science (New York, N.Y.) 1994;266(5184):387-8.
1994: B A Sullenger; Thomas R Cech
Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing.
Nature 1994;371(6498):619-22.
1994: F L Murphy; Y H Wang; Jack D Griffith; Thomas R Cech
Coaxially stacked RNA helices in the catalytic center of the Tetrahymena ribozyme.
Science (New York, N.Y.) 1994;265(5179):1709-12.
1994: J Lingner; L L Hendrick; Thomas R Cech
Telomerase RNAs of different ciliates have a common secondary structure and a permuted template.
Genes & development 1994;8(16):1984-98.
1994: B Laggerbauer; F L Murphy; Thomas R Cech
Two major tertiary folding transitions of the Tetrahymena catalytic RNA.
The EMBO journal 1994;13(11):2669-76.
1994: W D Downs; Thomas R Cech
A tertiary interaction in the Tetrahymena intron contributes to selection of the 5' splice site.
Genes & development 1994;8(10):1198-211.
1994: Thomas R Cech; S H Damberger; robin gutell
Representation of the secondary and tertiary structure of group I introns.
Nature structural biology 1994;1(5):273-80.
1994: B J Hicke; M C Willis; Tad H Koch; Thomas R Cech
Telomeric protein-DNA point contacts identified by photo-cross-linking using 5-bromodeoxyuridine.
Biochemistry 1994;33(11):3364-73.
1994: F L Murphy; Thomas R Cech
GAAA tetraloop and conserved bulge stabilize tertiary structure of a group I intron domain.
Journal of molecular biology 1994;236(1):49-63.
1994: Y H Wang; F L Murphy; Thomas R Cech; Jack D Griffith
Visualization of a tertiary structural domain of the Tetrahymena group I intron by electron microscopy.
Journal of molecular biology 1994;236(1):64-71.
1994: Scott A Strobel; Thomas R Cech
Translocation of an RNA duplex on a ribozyme.
Nature structural biology 1994;1(1):13-7.
1993: Thomas R Cech
The efficiency and versatility of catalytic RNA: implications for an RNA world.
Gene 1993;135(1-2):33-6.
1993: Scott A Strobel; Thomas R Cech
Tertiary interactions with the internal guide sequence mediate docking of the P1 helix into the catalytic core of the Tetrahymena ribozyme.
Biochemistry 1993;32(49):13593-604.
1993: B A Sullenger; Thomas R Cech
Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA.
Science (New York, N.Y.) 1993;262(5139):1566-9.
1993: M C Willis; B J Hicke; Olke C Uhlenbeck; Thomas R Cech; Tad H Koch
Photocrosslinking of 5-iodouracil-substituted RNA and DNA to proteins.
Science (New York, N.Y.) 1993;262(5137):1255-7.
1993: Guowei Fang; Thomas R Cech
Characterization of a G-quartet formation reaction promoted by the beta-subunit of the Oxytricha telomere-binding protein.
Biochemistry 1993;32(43):11646-57.
1993: Thomas R Cech
RNA. Fishing for fresh catalysts.
Nature 1993;365(6443):204-5.
1993: T S McConnell; Thomas R Cech; Daniel Herschlag
Guanosine binding to the Tetrahymena ribozyme: thermodynamic coupling with oligonucleotide binding.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(18):8362-6.
1993: Guowei Fang; Thomas R Cech
The beta subunit of Oxytricha telomere-binding protein promotes G-quartet formation by telomeric DNA.
Cell 1993;74(5):875-85.
1993: Daniel Herschlag; F Eckstein; Thomas R Cech
The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction.
Biochemistry 1993;32(32):8312-21.
1993: Daniel Herschlag; F Eckstein; Thomas R Cech
Contributions of 2'-hydroxyl groups of the RNA substrate to binding and catalysis by the Tetrahymena ribozyme. An energetic picture of an active site composed of RNA.
Biochemistry 1993;32(32):8299-311.
1993: A J Zaug; Megan M McEvoy; Thomas R Cech
Self-splicing of the group I intron from Anabaena pre-tRNA: requirement for base-pairing of the exons in the anticodon stem.
Biochemistry 1993;32(31):7946-53.
1993: Guowei Fang; Thomas R Cech
Oxytricha telomere-binding protein: DNA-dependent dimerization of the alpha and beta subunits.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(13):6056-60.
1993: F Ishikawa; Michael J Matunis; Gideon Dreyfuss; Thomas R Cech
Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n.
Molecular and cellular biology 1993;13(7):4301-10.
1993: F L Murphy; Thomas R Cech
An independently folding domain of RNA tertiary structure within the Tetrahymena ribozyme.
Biochemistry 1993;32(20):5291-300.
1993: Guowei Fang; J T Gray; Thomas R Cech
Oxytricha telomere-binding protein: separable DNA-binding and dimerization domains of the alpha-subunit.
Genes & development 1993;7(5):870-82.
1993: Thomas R Cech
Catalytic RNA: structure and mechanism.
Biochemical Society transactions 1993;21(2):229-34.
1993: J F Wang; W D Downs; Thomas R Cech
Movement of the guide sequence during RNA catalysis by a group I ribozyme.
Science (New York, N.Y.) 1993;260(5107):504-8.
1993: J A Piccirilli; Joseph Vyle; M H Caruthers; Thomas R Cech
Metal ion catalysis in the Tetrahymena ribozyme reaction.
Nature 1993;361(6407):85-8.
1992: P Legault; Daniel Herschlag; D W Celander; Thomas R Cech
Mutations at the guanosine-binding site of the Tetrahymena ribozyme also affect site-specific hydrolysis.
Nucleic acids research 1992;20(24):6613-9.
1992: Thomas R Cech; Daniel Herschlag; Joseph A Piccirilli; Anna Marie Pyle
RNA catalysis by a group I ribozyme. Developing a model for transition state stabilization.
The Journal of biological chemistry 1992;267(25):17479-82.
1992: A M Pyle; F L Murphy; Thomas R Cech
RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme.
Nature 1992;358(6382):123-8.
1992: Joseph A Piccirilli; T S McConnell; A J Zaug; Harry F Noller; Thomas R Cech
Aminoacyl esterase activity of the Tetrahymena ribozyme.
Science (New York, N.Y.) 1992;256(5062):1420-4.
1992: J F Wang; Thomas R Cech
Tertiary structure around the guanosine-binding site of the Tetrahymena ribozyme.
Science (New York, N.Y.) 1992;256(5056):526-9.
1992: A J Zaug; Thomas R Cech
The intervening sequence RNA of Tetrahymena is an enzyme. 1986.
Biotechnology (Reading, Mass.) 1992;24():57-62.
1991: T S Heuer; P S Chandry; Marlene Belfort; D W Celander; Thomas R Cech
Folding of group I introns from bacteriophage T4 involves internalization of the catalytic core.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11105-9.
1991: B Young; D Herschlag; Thomas R Cech
Mutations in a nonconserved sequence of the Tetrahymena ribozyme increase activity and specificity.
Cell 1991;67(5):1007-19.
1991: J T Gray; D W Celander; C M Price; Thomas R Cech
Cloning and expression of genes for the Oxytricha telomere-binding protein: specific subunit interactions in the telomeric complex.
Cell 1991;67(4):807-14.
1991: Guowei Fang; Thomas R Cech
Molecular cloning of telomere-binding protein genes from Stylonychia mytilis.
Nucleic acids research 1991;19(20):5515-8.
1991: A Gampel; Thomas R Cech
Binding of the CBP2 protein to a yeast mitochondrial group I intron requires the catalytic core of the RNA.
Genes & development 1991;5(10):1870-80.
1991: J A Dávila-Aponte; V A Huss; Mitchell L Sogin; Thomas R Cech
A self-splicing group I intron in the nuclear pre-rRNA of the green alga, Ankistrodesmus stipitatus.
Nucleic acids research 1991;19(16):4429-36.
1991: C A Grosshans; Thomas R Cech
A hammerhead ribozyme allows synthesis of a new form of the Tetrahymena ribozyme homogeneous in length with a 3' end blocked for transesterification.
Nucleic acids research 1991;19(14):3875-80.
1991: Daniel Herschlag; Joseph A Piccirilli; Thomas R Cech
Ribozyme-catalyzed and nonenzymatic reactions of phosphate diesters: rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom.
Biochemistry 1991;30(20):4844-54.
1991: Alan M Zahler; J R Williamson; Thomas R Cech; David M Prescott
Inhibition of telomerase by G-quartet DNA structures.
Nature 1991;350(6320):718-20.
1991: A M Pyle; Thomas R Cech
Ribozyme recognition of RNA by tertiary interactions with specific ribose 2'-OH groups.
Nature 1991;350(6319):628-31.
1991: Sarah A Woodson; Thomas R Cech
Alternative secondary structures in the 5' exon affect both forward and reverse self-splicing of the Tetrahymena intervening sequence RNA.
Biochemistry 1991;30(8):2042-50.
1991: Thomas R Cech
RNA editing: world's smallest introns?
Cell 1991;64(4):667-9.
1991: D W Celander; Thomas R Cech
Visualizing the higher order folding of a catalytic RNA molecule.
Science (New York, N.Y.) 1991;251(4992):401-7.
1990: D Herschlag; Thomas R Cech
Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 2. Kinetic description of the reaction of an RNA substrate that forms a mismatch at the active site.
Biochemistry 1990;29(44):10172-80.
1990: D Herschlag; Thomas R Cech
Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 1. Kinetic description of the reaction of an RNA substrate complementary to the active site.
Biochemistry 1990;29(44):10159-71.
1990: Anna Marie Pyle; James McSwiggen; Thomas R Cech
Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8187-91.
1990: M K Raghuraman; Thomas R Cech
Effect of monovalent cation-induced telomeric DNA structure on the binding of Oxytricha telomeric protein.
Nucleic acids research 1990;18(15):4543-52.
1990: W D Downs; Thomas R Cech
An ultraviolet-inducible adenosine-adenosine cross-link reflects the catalytic structure of the Tetrahymena ribozyme.
Biochemistry 1990;29(23):5605-13.
1990: Thomas R Cech
Nobel lecture. Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena.
Bioscience reports 1990;10(3):239-61.
1990: Siegfried Trattnig; R Stiglbauer; Karl Ungersböck; Thomas R Cech; Erwin Schindler; H Imhof
[Magnetic resonance tomography of the failed back surgery syndrome: a comparison with computed tomography].
RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin 1990;152(4):369-73.
1990: Daniel Herschlag; Thomas R Cech
DNA cleavage catalysed by the ribozyme from Tetrahymena.
Nature 1990;344(6265):405-9.
1990: D W Celander; Thomas R Cech
Iron(II)-ethylenediaminetetraacetic acid catalyzed cleavage of RNA and DNA oligonucleotides: similar reactivity toward single- and double-stranded forms.
Biochemistry 1990;29(6):1355-61.
1990: B J Hicke; D W Celander; G H MacDonald; C M Price; Thomas R Cech
Two versions of the gene encoding the 41-kilodalton subunit of the telomere binding protein of Oxytricha nova.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(4):1481-5.
1990: J A Latham; A J Zaug; Thomas R Cech
Self-splicing and enzymatic cleavage of RNA by a group I intervening sequence.
Methods in enzymology 1990;181():558-69.
1990: Thomas R Cech
Self-splicing of group I introns.
Annual review of biochemistry 1990;59():543-68.
1989: J R Williamson; M K Raghuraman; Thomas R Cech
Monovalent cation-induced structure of telomeric DNA: the G-quartet model.
Cell 1989;59(5):871-80.
1989: B Young; Thomas R Cech
Specificity for 3',5'-linked substrates in RNA-catalyzed RNA polymerization.
Journal of molecular evolution 1989;29(6):480-5.
1989: F L Murphy; Thomas R Cech
Alteration of substrate specificity for the endoribonucleolytic cleavage of RNA by the Tetrahymena ribozyme.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(23):9218-22.
1989: M K Raghuraman; Thomas R Cech
Assembly and self-association of oxytricha telomeric nucleoprotein complexes.
Cell 1989;59(4):719-28.
1989: P J Flor; J B Flanegan; Thomas R Cech
A conserved base pair within helix P4 of the Tetrahymena ribozyme helps to form the tertiary structure required for self-splicing.
The EMBO journal 1989;8(11):3391-9.
1989: Michael Yarus; J Levine; G B Morin; Thomas R Cech
A Tetrahymena intron nucleotide connected to the GTP/arginine site.
Nucleic acids research 1989;17(17):6969-81.
1989: E T Barfod; Thomas R Cech
The conserved U.G pair in the 5' splice site duplex of a group I intron is required in the first but not the second step of self-splicing.
Molecular and cellular biology 1989;9(9):3657-66.
1989: C A Grosshans; Thomas R Cech
Metal ion requirements for sequence-specific endoribonuclease activity of the Tetrahymena ribozyme.
Biochemistry 1989;28(17):6888-94.
1989: J A Latham; Thomas R Cech
Defining the inside and outside of a catalytic RNA molecule.
Science (New York, N.Y.) 1989;245(4915):276-82.
1989: Thomas R Cech
RNA chemistry. Ribozyme self-replication?
Nature 1989;339(6225):507-8.
1989: M K Raghuraman; C J Dunn; B J Hicke; Thomas R Cech
Oxytricha telomeric nucleoprotein complexes reconstituted with synthetic DNA.
Nucleic acids research 1989;17(11):4235-53.
1989: James McSwiggen; Thomas R Cech
Stereochemistry of RNA cleavage by the Tetrahymena ribozyme and evidence that the chemical step is not rate-limiting.
Science (New York, N.Y.) 1989;244(4905):679-83.
1989: Sarah A Woodson; Thomas R Cech
Reverse self-splicing of the tetrahymena group I intron: implication for the directionality of splicing and for intron transposition.
Cell 1989;57(2):335-45.
1989: C M Price; Thomas R Cech
Properties of the telomeric DNA-binding protein from Oxytricha nova.
Biochemistry 1989;28(2):769-74.
1989: Thomas R Cech
RNA as an enzyme.
Biochemistry international 1989;18(1):7-14.
1988: Thomas R Cech
Conserved sequences and structures of group I introns: building an active site for RNA catalysis--a review.
Gene 1988;73(2):259-71.
1988: A J Zaug; C A Grosshans; Thomas R Cech
Sequence-specific endoribonuclease activity of the Tetrahymena ribozyme: enhanced cleavage of certain oligonucleotide substrates that form mismatched ribozyme-substrate complexes.
Biochemistry 1988;27(25):8924-31.
1988: Thomas R Cech
Ribozymes and their medical implications.
JAMA : the journal of the American Medical Association 1988;260(20):3030-4.
1988: J V Price; Thomas R Cech
Determinants of the 3' splice site for self-splicing of the Tetrahymena pre-rRNA.
Genes & development 1988;2(11):1439-47.
1988: G B Morin; Thomas R Cech
Telomeric repeats of Tetrahymena malaccensis mitochondrial DNA: a multimodal distribution that fluctuates erratically during growth.
Molecular and cellular biology 1988;8(10):4450-8.
1988: E T Barfod; Thomas R Cech
Deletion of nonconserved helices near the 3' end of the rRNA intron of Tetrahymena thermophila alters self-splicing but not core catalytic activity.
Genes & development 1988;2(6):652-63.
1988: Thomas R Cech
G-strings at chromosome ends.
Nature 1988;332(6167):777-8.
1988: M D Been; Thomas R Cech
RNA as an RNA polymerase: net elongation of an RNA primer catalyzed by the Tetrahymena ribozyme.
Science (New York, N.Y.) 1988;239(4846):1412-6.
1988: G B Morin; Thomas R Cech
Mitochondrial telomeres: surprising diversity of repeated telomeric DNA sequences among six species of Tetrahymena.
Cell 1988;52(3):367-74.
1988: G B Morin; Thomas R Cech
Phylogenetic relationships and altered genome structures among Tetrahymena mitochondrial DNAs.
Nucleic acids research 1988;16(1):327-46.
1987: Sung-Huo S H Kim; Thomas R Cech
Three-dimensional model of the active site of the self-splicing rRNA precursor of Tetrahymena.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(24):8788-92.
1987: A J Zaug; Thomas R Cech
Self-splicing RNA and an RNA enzyme in Tetrahymena.
The Journal of protozoology 1987;34(4):416-7.
1987: C M Price; Thomas R Cech
Telomeric DNA-protein interactions of Oxytricha macronuclear DNA.
Genes & development 1987;1(8):783-93.
1987: J M Burke; M Belfort; Thomas R Cech; Roger Wayne Davies; R J Schweyen; D A Shub; J W Szostak; H F Tabak
Structural conventions for group I introns.
Nucleic acids research 1987;15(18):7217-21.
1987: M D Been; Thomas R Cech
Selection of circularization sites in a group I IVS RNA requires multiple alignments of an internal template-like sequence.
Cell 1987;50(6):951-61.
1987: J V Price; J Engberg; Thomas R Cech
5' exon requirement for self-splicing of the Tetrahymena thermophila pre-ribosomal RNA and identification of a cryptic 5' splice site in the 3' exon.
Journal of molecular biology 1987;196(1):49-60.
1987: Thomas R Cech
The chemistry of self-splicing RNA and RNA enzymes.
Science (New York, N.Y.) 1987;236(4808):1532-9.
1987: N K Tanner; Thomas R Cech
Guanosine binding required for cyclization of the self-splicing intervening sequence ribonucleic acid from Tetrahymena thermophila.
Biochemistry 1987;26(12):3330-40.
1987: M D Been; E T Barfod; J M Burke; J V Price; N K Tanner; A J Zaug; Thomas R Cech
Structures involved in Tetrahymena rRNA self-splicing and RNA enzyme activity.
Cold Spring Harbor symposia on quantitative biology 1987;52():147-57.
1986: A J Zaug; M D Been; Thomas R Cech
The Tetrahymena ribozyme acts like an RNA restriction endonuclease.
Nature 1986;324(6096):429-33.
1986: Thomas R Cech
RNA as an enzyme.
Scientific American 1986;255(5):64-75.
1986: M D Been; Thomas R Cech
One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing, trans-splicing, and RNA enzyme activity.
Cell 1986;47(2):207-16.
1986: G B Morin; Thomas R Cech
The telomeres of the linear mitochondrial DNA of Tetrahymena thermophila consist of 53 bp tandem repeats.
Cell 1986;46(6):873-83.
1986: B L Bass; Thomas R Cech
Ribozyme inhibitors: deoxyguanosine and dideoxyguanosine are competitive inhibitors of self-splicing of the Tetrahymena ribosomal ribonucleic acid precursor.
Biochemistry 1986;25(16):4473-7.
1986: A J Zaug; Thomas R Cech
The Tetrahymena intervening sequence ribonucleic acid enzyme is a phosphotransferase and an acid phosphatase.
Biochemistry 1986;25(16):4478-82.
1986: G Garriga; Alan M Lambowitz; T Inoue; Thomas R Cech
Mechanism of recognition of the 5' splice site in self-splicing group I introns.
Nature 1986;322(6074):86-9.
1986: Thomas R Cech
A model for the RNA-catalyzed replication of RNA.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(12):4360-3.
1986: T Inoue; F X Sullivan; Thomas R Cech
New reactions of the ribosomal RNA precursor of Tetrahymena and the mechanism of self-splicing.
Journal of molecular biology 1986;189(1):143-65.
1986: J M Burke; K D Irvine; K J Kaneko; B J Kerker; A B Oettgen; W M Tierney; C L Williamson; A J Zaug; Thomas R Cech
Role of conserved sequence elements 9L and 2 in self-splicing of the Tetrahymena ribosomal RNA precursor.
Cell 1986;45(2):167-76.
1986: A J Zaug; Thomas R Cech
The intervening sequence RNA of Tetrahymena is an enzyme.
Science (New York, N.Y.) 1986;231(4737):470-5.
1986: Thomas R Cech
The generality of self-splicing RNA: relationship to nuclear mRNA splicing.
Cell 1986;44(2):207-10.
1986: Thomas R Cech
Biologic catalysis by RNA.
Harvey lectures 1986;82():123-44.
1986: Thomas R Cech; B L Bass
Biological catalysis by RNA.
Annual review of biochemistry 1986;55():599-629.
1985: M D Been; Thomas R Cech
Sites of circularization of the Tetrahymena rRNA IVS are determined by sequence and influenced by position and secondary structure.
Nucleic acids research 1985;13(23):8389-408.
1985: T Inoue; F X Sullivan; Thomas R Cech
Intermolecular exon ligation of the rRNA precursor of Tetrahymena: oligonucleotides can function as 5' exons.
Cell 1985;43(2 Pt 1):431-7.
1985: N K Tanner; Thomas R Cech
Self-catalyzed cyclization of the intervening sequence RNA of Tetrahymena: inhibition by methidiumpropyl.EDTA and localization of the major dye binding sites.
Nucleic acids research 1985;13(21):7759-79.
1985: N K Tanner; Thomas R Cech
Self-catalyzed cyclization of the intervening sequence RNA of Tetrahymena: inhibition by intercalating dyes.
Nucleic acids research 1985;13(21):7741-58.
1985: A J Zaug; J R Kent; Thomas R Cech
Reactions of the intervening sequence of the Tetrahymena ribosomal ribonucleic acid precursor: pH dependence of cyclization and site-specific hydrolysis.
Biochemistry 1985;24(22):6211-8.
1985: A J Zaug; Thomas R Cech
Oligomerization of intervening sequence RNA molecules in the absence of proteins.
Science (New York, N.Y.) 1985;229(4718):1060-4.
1985: F X Sullivan; Thomas R Cech
Reversibility of cyclization of the Tetrahymena rRNA intervening sequence: implication for the mechanism of splice site choice.
Cell 1985;42(2):639-48.
1985: J V Price; Thomas R Cech
Coupling of Tetrahymena ribosomal RNA splicing to beta-galactosidase expression in Escherichia coli.
Science (New York, N.Y.) 1985;228(4700):719-22.
1985: J V Price; G L Kieft; J R Kent; E L Sievers; Thomas R Cech
Sequence requirements for self-splicing of the Tetrahymena thermophila pre-ribosomal RNA.
Nucleic acids research 1985;13(6):1871-89.
1985: T Inoue; Thomas R Cech
Secondary structure of the circular form of the Tetrahymena rRNA intervening sequence: a technique for RNA structure analysis using chemical probes and reverse transcriptase.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(3):648-52.
1985: Thomas R Cech
Self-splicing RNA: implications for evolution.
International review of cytology 1985;93():3-22.
1984: D E Gottschling; Thomas R Cech
Chromatin structure of the molecular ends of Oxytricha macronuclear DNA: phased nucleosomes and a telomeric complex.
Cell 1984;38(2):501-10.
1984: A J Zaug; J R Kent; Thomas R Cech
A labile phosphodiester bond at the ligation junction in a circular intervening sequence RNA.
Science (New York, N.Y.) 1984;224(4649):574-8.
1984: B L Bass; Thomas R Cech
Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: implications for biological catalysis by RNA.
Nature 1984;308(5962):820-6.
1984: T E Palen; Thomas R Cech
Chromatin structure at the replication origins and transcription-initiation regions of the ribosomal RNA genes of Tetrahymena.
Cell 1984;36(4):933-42.
1984: M L Pardue; J M Fostel; Thomas R Cech
DNA-protein interactions in the Drosophila virilis mitochondrial chromosome.
Nucleic acids research 1984;12(4):1991-9.
1983: Thomas R Cech
RNA splicing: three themes with variations.
Cell 1983;34(3):713-6.
1983: Thomas R Cech; N K Tanner; Ignacio Tinoco; B R Weir; M Zuker; P S Perlman
Secondary structure of the Tetrahymena ribosomal RNA intervening sequence: structural homology with fungal mitochondrial intervening sequences.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(13):3903-7.
1983: S L Brehm; Thomas R Cech
Fate of an intervening sequence ribonucleic acid: excision and cyclization of the Tetrahymena ribosomal ribonucleic acid intervening sequence in vivo.
Biochemistry 1983;22(10):2390-7.
1983: D E Gottschling; T E Palen; Thomas R Cech
Different nucleosome spacing in transcribed and non-transcribed regions of the ribosomal RNA gene in Tetrahymena thermophila.
Nucleic acids research 1983;11(7):2093-109.
1983: T E Palen; Thomas R Cech
Transcribed and non-transcribed regions of Tetrahymena ribosomal gene chromatin have different accessibilities to micrococcal nuclease.
Nucleic acids research 1983;11(7):2077-91.
1983: A J Zaug; P J Grabowski; Thomas R Cech
Autocatalytic cyclization of an excised intervening sequence RNA is a cleavage-ligation reaction.
Nature 1983;301(5901):578-83.
1982: K Kruger; P J Grabowski; A J Zaug; J Sands; D E Gottschling; Thomas R Cech
Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena.
Cell 1982;31(1):147-57.
1982: A J Zaug; Thomas R Cech
The intervening sequence excised from the ribosomal RNA precursor of Tetrahymena contains a 5-terminal guanosine residue not encoded by the DNA.
Nucleic acids research 1982;10(9):2823-38.
1981: Thomas R Cech; A J Zaug; P J Grabowski
In vitro splicing of the ribosomal RNA precursor of Tetrahymena: involvement of a guanosine nucleotide in the excision of the intervening sequence.
Cell 1981;27(3 Pt 2):487-96.
1981: Thomas R Cech; S L Brehm
Replication of the extrachromosomal ribosomal RNA genes of Tetrahymena thermophilia.
Nucleic acids research 1981;9(14):3531-43.
1981: Thomas R Cech
Alkaline gel electrophoresis of deoxyribonucleic acid photoreacted with trimethylpsoralen: rapid and sensitive detection of interstrand cross-links.
Biochemistry 1981;20(6):1431-7.
1981: P J Grabowski; A J Zaug; Thomas R Cech
The intervening sequence of the ribosomal RNA precursor is converted to a circular RNA in isolated nuclei of Tetrahymena.
Cell 1981;23(2):467-76.
1980: D A Potter; J M Fostel; M Berninger; M L Pardue; Thomas R Cech
DNA-protein interactions in the Drosophila melanogaster mitochondrial genome as deduced from trimethylpsoralen crosslinking patterns.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(7):4118-22.
1980: Thomas R Cech; K M Karrer
Chromatin structure of the ribosomal RNA genes of Tetrahymena thermophila as analyzed by trimethylpsoralen crosslinking in vivo.
Journal of molecular biology 1980;136(4):395-416.
1980: A J Zaug; Thomas R Cech
In vitro splicing of the ribosomal RNA precursor in nuclei of Tetrahymena.
Cell 1980;19(2):331-8.
1979: Thomas R Cech; D C Rio
Localization of transcribed regions on extrachromosomal ribosomal RNA genes of Tetrahymena thermophila by R-loop mapping.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(10):5051-5.
1979: Thomas R Cech; M A Pathak; R K Biswas
An electron microscopic study of the photochemical cross-linking of DNA in guinea pig epidermis by psoralen derivatives.
Biochimica et biophysica acta 1979;562(2):342-60.
1978: Thomas R Cech; D Potter; M L Pardue
Chromatin structure in living cells.
Cold Spring Harbor symposia on quantitative biology 1978;42 Pt 1():191-8.
1977: Thomas R Cech; D Potter; M L Pardue
Electron microscopy of DNA cross-linked with trimethylpsoralen: a probe for chromatin structure.
Biochemistry 1977;16(24):5313-21.
1977: Thomas R Cech; M L Pardue
Cross-linking of DNA with trimethylpsoralen is a probe for chromatin structure.
Cell 1977;11(3):631-40.
1976: Thomas R Cech; M L Pardue
Electron microscopy of DNA crosslinked with trimethylpsoralen: test of the secondary structure of eukaryotic inverted repeat sequences.
Proceedings of the National Academy of Sciences of the United States of America 1976;73(8):2644-8.
1976: G Wiesehahn; Thomas R Cech; J E Hearst
A study of DNA denaturation in the ultracentrifuge.
Biopolymers 1976;15(8):1591-613.
1976: Thomas R Cech; F Reisler; J E Hearst
Partial denaturation of mouse DNA in preparative CsCl density gradients at alkaline pH.
Biochemistry 1976;15(9):1865-73.
1976: Thomas R Cech; J E Hearst
Organization of highly repeated sequences in mouse main-band DNA.
Journal of molecular biology 1976;100(3):227-56.
1975: Thomas R Cech; J E Hearst
An electron microscopic study of mouse foldback DNA.
Cell 1975;5(4):429-46.
1974: J E Hearst; Thomas R Cech; K A Marx; A Rosenfeld; J R Allen
Characterization of the rapidly renaturing sequences in the main CsCl density bands of Drosophila, mouse, and human DNA.
Cold Spring Harbor symposia on quantitative biology 1974;38():329-39.
1973: Thomas R Cech; A Rosenfeld; J E Hearst
Characterization of the most rapidly renaturing sequences in mouse main-band DNA.
Journal of molecular biology 1973;81(3):299-325.