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Arthur Cederbaum

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Living Beings

Anatomy

Physiology

Lipid Peroxidation

Disorders

Oxidative Stress

Phenomena

Oxidation-Reduction

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Co-Publications
Name
27
Wu, Defeng
13
Nieto, Natalia
12
Puntarulo, Susana
12
Bai, Jingxiang
12
Caro, Andres
10
Lu, Yongke
10
Stoyanovsky, Detcho
7
Wang, Xiaodong
7
Gong, Pengfei
6
Marí, Montserrat
6
Dey, Aparajita
5
Kessova, Irina
5
Zhuge, Jian
5
Pérez, María José
4
Jimenez-Lopez, Jose

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Publications

TOP 3
Wang Xiaodong; Lu Yongke; Xie Bin; Cederbaum Arthur I
Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase.
Cederbaum Arthur I; Lu Yongke; Wu Defeng
Role of oxidative stress in alcohol-induced liver injury.
Wu Defeng; Cederbaum Arthur I
Oxidative stress and alcoholic liver disease.

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All Publications

2009: Wang Xiaodong; Lu Yongke; Xie Bin; Cederbaum Arthur I
Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase.
Free radical biology & medicine 2009;47(5):518-28.
2009: Cederbaum Arthur I; Lu Yongke; Wu Defeng
Role of oxidative stress in alcohol-induced liver injury.
Archives of toxicology 2009;83(6):519-48.
2009: Wu Defeng; Cederbaum Arthur I
Oxidative stress and alcoholic liver disease.
Seminars in liver disease 2009;29(2):141-54.
2009: Zhuge Jian; Cederbaum Arthur I
Inhibition of the mitochondrial permeability transition by cyclosporin A prevents pyrazole plus lipopolysaccharide-induced liver injury in mice.
Free radical biology & medicine 2009;46(3):406-13.
2009: Caro Andres A; Evans Kerry L; Cederbaum Arthur I
CYP2E1 overexpression inhibits microsomal Ca2+-ATPase activity in HepG2 cells.
Toxicology 2009;255(3):171-6.
2008: Lu Yongke; Gong Pengfei; Cederbaum Arthur I
Pyrazole induced oxidative liver injury independent of CYP2E1/2A5 induction due to Nrf2 deficiency.
Toxicology 2008;252(1-3):9-16.
2008: Wang Xiaodong; Cederbaum Arthur I
S-adenosyl-L-methionine decreases the elevated hepatotoxicity induced by Fas agonistic antibody plus acute ethanol pretreatment in mice.
Archives of biochemistry and biophysics 2008;477(1):1-11.
2008: Lu Yongke; Zhuge Jian; Wang Xiaodong; Bai Jingxiang; Cederbaum Arthur I
Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice.
Hepatology (Baltimore, Md.) 2008;47(5):1483-94.
2008: Lu Yongke; Cederbaum Arthur I
CYP2E1 and oxidative liver injury by alcohol.
Free radical biology & medicine 2008;44(5):723-38.
2008: Jimenez-Lopez Jose M; Wu Defeng; Cederbaum Arthur I
Synergistic toxicity induced by prolonged glutathione depletion and inhibition of nuclear factor-kappaB signaling in liver cells.
Toxicology in vitro : an international journal published in association with BIBRA 2008;22(1):106-15.
2008: Wu Defeng; Cederbaum Arthur I
Development and properties of HepG2 cells that constitutively express CYP2E1.
Methods in molecular biology (Clifton, N.J.) 2008;447():137-50.
2007: Lu Yongke; Cederbaum Arthur
The mode of cisplatin-induced cell death in CYP2E1-overexpressing HepG2 cells: modulation by ERK, ROS, glutathione, and thioredoxin.
Free radical biology & medicine 2007;43(7):1061-75.
2007: Zhuge Jian; Cederbaum Arthur I
Depletion of S-adenosyl-l-methionine with cycloleucine potentiates cytochrome P450 2E1 toxicity in primary rat hepatocytes.
Archives of biochemistry and biophysics 2007;466(2):177-85.
2007: Donohue Terrence M; Cederbaum Arthur I; French Samuel W; Barve Shirish; Gao Bin; Osna Natalia A
Role of the proteasome in ethanol-induced liver pathology.
Alcoholism, clinical and experimental research 2007;31(9):1446-59.
2007: Dey Aparajita; Caro Andres A; Cederbaum Arthur I
S-adenosyl methionine protects ob/ob mice from CYP2E1-mediated liver injury.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(1):G91-103.
2007: Dey Aparajita; Cederbaum Arthur I
Induction of cytochrome P450 2E1 [corrected] promotes liver injury in ob/ob mice.
Hepatology (Baltimore, Md.) 2007;45(6):1355-65.
2007: Kessova Irina G; Cederbaum Arthur I
Mitochondrial alterations in livers of Sod1-/- mice fed alcohol.
Free radical biology & medicine 2007;42(10):1470-80.
2007: Dey Aparajita; Cederbaum Arthur I
Geldanamycin, an inhibitor of Hsp90 increases cytochrome P450 2E1 mediated toxicity in HepG2 cells through sustained activation of the p38MAPK pathway.
Archives of biochemistry and biophysics 2007;461(2):275-86.
2007: Wang Xiaodong; Cederbaum Arthur I
Acute ethanol pretreatment increases FAS-mediated liver injury in mice: role of oxidative stress and CYP2E1-dependent and -independent pathways.
Free radical biology & medicine 2007;42(7):971-84.
2007: Caro Andres A; Cederbaum Arthur I
Role of intracellular calcium and phospholipase A2 in arachidonic acid-induced toxicity in liver cells overexpressing CYP2E1.
Archives of biochemistry and biophysics 2007;457(2):252-63.
2006: Bai Jingxiang; Cederbaum Arthur I
Cycloheximide protects HepG2 cells from serum withdrawal-induced apoptosis by decreasing p53 and phosphorylated p53 levels.
The Journal of pharmacology and experimental therapeutics 2006;319(3):1435-43.
2006: Zhuge Jian; Cederbaum Arthur I
Increased toxicity by transforming growth factor-beta 1 in liver cells overexpressing CYP2E1.
Free radical biology & medicine 2006;41(7):1100-12.
2006: Cederbaum Arthur I
Cytochrome P450 2E1-dependent oxidant stress and upregulation of anti-oxidant defense in liver cells.
Journal of gastroenterology and hepatology 2006;21 Suppl 3():S22-5.
2006: Wu Defeng; Cederbaum Arthur
Nitric oxide donors prevent while the nitric oxide synthase inhibitor L-NAME increases arachidonic acid plus CYP2E1-dependent toxicity.
Toxicology and applied pharmacology 2006;216(2):282-92.
2006: Cederbaum Arthur I
CYP2E1--biochemical and toxicological aspects and role in alcohol-induced liver injury.
The Mount Sinai journal of medicine, New York 2006;73(4):657-72.
2006: Lu Yongke; Cederbaum Arthur I
Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: role of cytochrome P450 2E1 and 2A5.
Hepatology (Baltimore, Md.) 2006;44(1):263-74.
2006: Caro Andres A; Cederbaum Arthur I
Role of phosphatidylinositol 3-kinase/AKT as a survival pathway against CYP2E1-dependent toxicity.
The Journal of pharmacology and experimental therapeutics 2006;318(1):360-72.
2006: Bai Jingxiang; Cederbaum Arthur I
Adenovirus-mediated expression of CYP2E1 produces liver toxicity in mice.
Toxicological sciences : an official journal of the Society of Toxicology 2006;91(2):365-71.
2006: Inami Keiko; Nims Raymond W; Srinivasan Aloka; Citro Michael L; Saavedra Joseph E; Cederbaum Arthur I; Keefer Larry K
Metabolism of a liver-selective nitric oxide-releasing agent, V-PYRRO/NO, by human microsomal cytochromes P450.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2006;14(4):309-15.
2006: Dey Aparajita; Cederbaum Arthur I
Geldanamycin, an inhibitor of Hsp90, potentiates cytochrome P4502E1-mediated toxicity in HepG2 cells.
The Journal of pharmacology and experimental therapeutics 2006;317(3):1391-9.
2006: Gong Pengfei; Cederbaum Arthur I
Transcription factor Nrf2 protects HepG2 cells against CYP2E1 plus arachidonic acid-dependent toxicity.
The Journal of biological chemistry 2006;281(21):14573-9.
2006: Wang Xiaodong; Cederbaum Arthur I
S-adenosyl-L-methionine attenuates hepatotoxicity induced by agonistic Jo2 Fas antibody following CYP2E1 induction in mice.
The Journal of pharmacology and experimental therapeutics 2006;317(1):44-52.
2006: Wu Defeng; Cederbaum Arthur I
Opposite action of S-adenosyl methionine and its metabolites on CYP2E1-mediated toxicity in pyrazole-induced rat hepatocytes and HepG2 E47 cells.
American journal of physiology. Gastrointestinal and liver physiology 2006;290(4):G674-84.
2006: Dey Aparajita; Kessova Irina G; Cederbaum Arthur I
Decreased protein and mRNA expression of ER stress proteins GRP78 and GRP94 in HepG2 cells over-expressing CYP2E1.
Archives of biochemistry and biophysics 2006;447(2):155-66.
2006: Dey Aparajita; Cederbaum Arthur I
Alcohol and oxidative liver injury.
Hepatology (Baltimore, Md.) 2006;43(2 Suppl 1):S63-74.
2006: Caro Andres A; Cederbaum Arthur I
Role of cytochrome P450 in phospholipase A2- and arachidonic acid-mediated cytotoxicity.
Free radical biology & medicine 2006;40(3):364-75.
2006: Bai Jingxiang; Cederbaum Arthur I
Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione.
The Journal of biological chemistry 2006;281(8):5128-36.
2006: Lu Yongke; Cederbaum Arthur I
Cisplatin-induced hepatotoxicity is enhanced by elevated expression of cytochrome P450 2E1.
Toxicological sciences : an official journal of the Society of Toxicology 2006;89(2):515-23.
2006: Gong Pengfei; Cederbaum Arthur I
Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1.
Hepatology (Baltimore, Md.) 2006;43(1):144-53.
2006: Zhuge Jian; Cederbaum Arthur I
Serum deprivation-induced HepG2 cell death is potentiated by CYP2E1.
Free radical biology & medicine 2006;40(1):63-74.
2005: Jimenez-Lopez Jose M; Cederbaum Arthur I
CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury.
Expert opinion on drug metabolism & toxicology 2005;1(4):671-85.
2005: Kessova Irina G; Cederbaum Arthur I
The effect of CYP2E1-dependent oxidant stress on activity of proteasomes in HepG2 cells.
The Journal of pharmacology and experimental therapeutics 2005;315(1):304-12.
2005: Lakshman Raj; Cederbaum Arthur I; Hoek Jan B; Konishi Masahiro; Koop Dennis; Donohu Terrence M
Use of CYP2E1-transfected human liver cell lines in elucidating the actions of ethanol.
Alcoholism, clinical and experimental research 2005;29(9):1726-34.
2005: Wu Defeng; Cederbaum Arthur I
Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1.
Toxicology and applied pharmacology 2005;207(2 Suppl):70-6.
2005: Nieto Natalia; Cederbaum Arthur I
S-adenosylmethionine blocks collagen I production by preventing transforming growth factor-beta induction of the COL1A2 promoter.
The Journal of biological chemistry 2005;280(35):30963-74.
2005: Wang Xiaodong; Lu Yongke; Cederbaum Arthur I
Induction of cytochrome P450 2E1 increases hepatotoxicity caused by Fas agonistic Jo2 antibody in mice.
Hepatology (Baltimore, Md.) 2005;42(2):400-10.
2005: Lu Yongke; Wang Xiaodong; Cederbaum Arthur I
Lipopolysaccharide-induced liver injury in rats treated with the CYP2E1 inducer pyrazole.
American journal of physiology. Gastrointestinal and liver physiology 2005;289(2):G308-19.
2005: Caro Andres A; Cederbaum Arthur I
Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine.
Biochemical pharmacology 2005;69(7):1081-93.
2005: Jimenez-Lopez Jose M; Cederbaum Arthur I
Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells.
The Journal of pharmacology and experimental therapeutics 2005;312(3):998-1006.
2005: Carmiel-Haggai Michal; Cederbaum Arthur I; Nieto Natalia
A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(1):136-8.
2004: Gong Pengfei; Hu Bin; Cederbaum Arthur I
Diallyl sulfide induces heme oxygenase-1 through MAPK pathway.
Archives of biochemistry and biophysics 2004;432(2):252-60.
2004: Wu Defeng; Cederbaum Arthur
Glutathione depletion in CYP2E1-expressing liver cells induces toxicity due to the activation of p38 mitogen-activated protein kinase and reduction of nuclear factor-kappaB DNA binding activity.
Molecular pharmacology 2004;66(3):749-60.
2004: Bai Jingxiang; Cederbaum Arthur I
Adenovirus mediated overexpression of CYP2E1 increases sensitivity of HepG2 cells to acetaminophen induced cytotoxicity.
Molecular and cellular biochemistry 2004;262(1-2):165-76.
2004: Pan Meihui; Cederbaum Arthur I; Zhang Yuan-Li; Ginsberg Henry N; Williams Kevin Jon; Fisher Edward A
Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production.
The Journal of clinical investigation 2004;113(9):1277-87.
2004: Caro Andres A; Cederbaum Arthur I
Antioxidant properties of S-adenosyl-L-methionine in Fe(2+)-initiated oxidations.
Free radical biology & medicine 2004;36(10):1303-16.
2004: Jimenez-Lopez Jose M; Cederbaum Arthur I
Green tea polyphenol epigallocatechin-3-gallate protects HepG2 cells against CYP2E1-dependent toxicity.
Free radical biology & medicine 2004;36(3):359-70.
2004: Gong Pengfei; Cederbaum Arthur I; Nieto Natalia
Heme oxygenase-1 protects HepG2 cells against cytochrome P450 2E1-dependent toxicity.
Free radical biology & medicine 2004;36(3):307-18.
2004: Gong Pengfei; Cederbaum Arthur I; Nieto Natalia
The liver-selective nitric oxide donor O2-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO) protects HepG2 cells against cytochrome P450 2E1-dependent toxicity.
Molecular pharmacology 2004;65(1):130-8.
2004: Caro Andres A; Cederbaum Arthur I
Oxidative stress, toxicology, and pharmacology of CYP2E1.
Annual review of pharmacology and toxicology 2004;44():27-42.
2003: Carmiel-Haggai Michal; Cederbaum Arthur I; Nieto Natalia
Binge ethanol exposure increases liver injury in obese rats.
Gastroenterology 2003;125(6):1818-33.
2003: Pérez María José; Cederbaum Arthur I
Adenovirus-mediated expression of Cu/Zn- or Mn-superoxide dismutase protects against CYP2E1-dependent toxicity.
Hepatology (Baltimore, Md.) 2003;38(5):1146-58.
2003: Kessova Irina G; Ho Ye-Shih; Thung Swan; Cederbaum Arthur I
Alcohol-induced liver injury in mice lacking Cu, Zn-superoxide dismutase.
Hepatology (Baltimore, Md.) 2003;38(5):1136-45.
2003: Holownia Adam; Cederbaum Arthur I
Threshold for antiproliferative and proapoptotic activity of ttaxol in HepG2 cells expressing human CYP3A4: effect of P-glycoprotein transporters.
Pharmacology 2003;69(3):142-9.
2003: Kessova Irina; Cederbaum Arthur I
CYP2E1: biochemistry, toxicology, regulation and function in ethanol-induced liver injury.
Current molecular medicine 2003;3(6):509-18.
2003: Caro Andres A; Cederbaum Arthur I
Role of phospholipase A2 activation and calcium in CYP2E1-dependent toxicity in HepG2 cells.
The Journal of biological chemistry 2003;278(36):33866-77.
2003: Gong Pengfei; Cederbaum Arthur I; Nieto Natalia
Increased expression of cytochrome P450 2E1 induces heme oxygenase-1 through ERK MAPK pathway.
The Journal of biological chemistry 2003;278(32):29693-700.
2003: Ishii Hiromasa; Adachi Masayuki; Fernández-Checa Jose C; Cederbaum Arthur I; Deaciuc Ion V; Nanji Amin A
Role of apoptosis in alcoholic liver injury.
Alcoholism, clinical and experimental research 2003;27(7):1207-12.
2003: Cederbaum Arthur I
Iron and CYP2E1-dependent oxidative stress and toxicity.
Alcohol (Fayetteville, N.Y.) 2003;30(2):115-20.
2003: Pérez María José; Cederbaum Arthur I
Proteasome inhibition potentiates CYP2E1-mediated toxicity in HepG2 cells.
Hepatology (Baltimore, Md.) 2003;37(6):1395-404.
2003: Nieto Natalia; Cederbaum Arthur I
Increased Sp1-dependent transactivation of the LAMgamma 1 promoter in hepatic stellate cells co-cultured with HepG2 cells overexpressing cytochrome P450 2E1.
The Journal of biological chemistry 2003;278(17):15360-72.
2003: Pérez María José; Cederbaum Arthur I
Metallothionein 2A induction by zinc protects HEPG2 cells against CYP2E1-dependent toxicity.
Free radical biology & medicine 2003;34(4):443-55.
2003: Bai Jingxiang; Cederbaum Arthur I
Catalase protects HepG2 cells from apoptosis induced by DNA-damaging agents by accelerating the degradation of p53.
The Journal of biological chemistry 2003;278(7):4660-7.
2003: Nieto Natalia; Marí Montserrat; Cederbaum Arthur I
Cytochrome P450 2E1 responsiveness in the promoter of glutamate-cysteine ligase catalytic subunit.
Hepatology (Baltimore, Md.) 2003;37(1):96-106.
2003: Wu Defeng; Cederbaum Arthur I
Role of p38 MAPK in CYP2E1-dependent arachidonic acid toxicity.
The Journal of biological chemistry 2003;278(2):1115-24.
2003: Wu Defeng; Cederbaum Arthur I
Alcohol, oxidative stress, and free radical damage.
Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism 2003;27(4):277-84.
2002: Caro Andres A; Cederbaum Arthur I
Ca2+-dependent and independent mitochondrial damage in HepG2 cells that overexpress CYP2E1.
Archives of biochemistry and biophysics 2002;408(2):162-70.
2002: Pérez María José; Cederbaum Arthur I
Antioxidant and pro-oxidant effects of a manganese porphyrin complex against CYP2E1-dependent toxicity.
Free radical biology & medicine 2002;33(1):111-27.
2002: Wu Defeng; Cederbaum Arthur I
Cyclosporine A protects against arachidonic acid toxicity in rat hepatocytes: role of CYP2E1 and mitochondria.
Hepatology (Baltimore, Md.) 2002;35(6):1420-30.
2002: Marí Montserrat; Bai Jingxiang; Cederbaum Arthur I
Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against toxicity caused by glutathione depletion in HepG2 cells expressing CYP2E1.
The Journal of pharmacology and experimental therapeutics 2002;301(1):111-8.
2002: Nieto Natalia; Friedman Scott L; Cederbaum Arthur I
Cytochrome P450 2E1-derived reactive oxygen species mediate paracrine stimulation of collagen I protein synthesis by hepatic stellate cells.
The Journal of biological chemistry 2002;277(12):9853-64.
2002: Jaeschke Hartmut; Gores Gregory J; Cederbaum Arthur I; Hinson Jack A; Pessayre Dominique; Lemasters John J
Mechanisms of hepatotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2002;65(2):166-76.
2002: Nieto Natalia; Friedman Scott L; Cederbaum Arthur I
Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived reactive oxygen species.
Hepatology (Baltimore, Md.) 2002;35(1):62-73.
2002: Marí Montserrat; Bai Jingxiang; Cederbaum Arthur I
Toxicity by pyruvate in HepG2 cells depleted of glutathione: role of mitochondria.
Free radical biology & medicine 2002;32(1):73-83.
2002: Caro Andres A; Cederbaum Arthur I
Role of calcium and calcium-activated proteases in CYP2E1-dependent toxicity in HEPG2 cells.
The Journal of biological chemistry 2002;277(1):104-13.
2001: Cederbaum A I; Wu D; Mari M; Bai J
CYP2E1-dependent toxicity and oxidative stress in HepG2 cells.
Free radical biology & medicine 2001;31(12):1539-43.
2001: Cederbaum A I
Introduction-serial review: alcohol, oxidative stress and cell injury.
Free radical biology & medicine 2001;31(12):1524-6.
2001: Caro A A; Cederbaum A I
Synergistic toxicity of iron and arachidonic acid in HepG2 cells overexpressing CYP2E1.
Molecular pharmacology 2001;60(4):742-52.
2001: Novakov C P; Feierman D; Cederbaum A I; Stoyanovsky D A
An ESR and HPLC-EC assay for the detection of alkyl radicals.
Chemical research in toxicology 2001;14(9):1239-46.
2001: Caro A A; Cederbaum A I; Stoyanovsky D A
Oxidation of the ketoxime acetoxime to nitric oxide by oxygen radical-generating systems.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2001;5(4):413-24.
2001: Clancy R; Cederbaum A I; Stoyanovsky D A
Preparation and properties of S-nitroso-L-cysteine ethyl ester, an intracellular nitrosating agent.
Journal of medicinal chemistry 2001;44(12):2035-8.
2001: Casey C A; Nanji A; Cederbaum A I; Adachi M; Takahashi T
Alcoholic liver disease and apoptosis.
Alcoholism, clinical and experimental research 2001;25(5 Suppl ISBRA):49S-53S.
2001: Wu D; Cederbaum A I
Removal of glutathione produces apoptosis and necrosis in HepG2 cells overexpressing CYP2E1.
Alcoholism, clinical and experimental research 2001;25(4):619-28.
2001: Pérez M J; Cederbaum A I
Spin trapping agents (Tempol and POBN) protect HepG2 cells overexpressing CYP2E1 against arachidonic acid toxicity.
Free radical biology & medicine 2001;30(7):734-46.
2001: Wu D; Cederbaum A I
Sodium salicylate increases CYP2E1 levels and enhances arachidonic acid toxicity in HepG2 cells and cultured rat hepatocytes.
Molecular pharmacology 2001;59(4):795-805.
2001: Marí M; Cederbaum A I
Induction of catalase, alpha, and microsomal glutathione S-transferase in CYP2E1 overexpressing HepG2 cells and protection against short-term oxidative stress.
Hepatology (Baltimore, Md.) 2001;33(3):652-61.
2001: Bai J; Cederbaum A I
Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against cytochrome P450 2E1-dependent toxicity in HepG2 cells.
The Journal of biological chemistry 2001;276(6):4315-21.
2001: Marí M; Wu D; Nieto N; Cederbaum A I
CYP2E1-dependent toxicity and up-regulation of antioxidant genes.
Journal of biomedical science 2001;8(1):52-8.
2000: Goasduff T; Cederbaum A I
CYP2E1 degradation by in vitro reconstituted systems: role of the molecular chaperone hsp90.
Archives of biochemistry and biophysics 2000;379(2):321-30.
2000: Nieto N; Greenwel P; Friedman S L; Zhang F; Dannenberg A J; Cederbaum A I
Ethanol and arachidonic acid increase alpha 2(I) collagen expression in rat hepatic stellate cells overexpressing cytochrome P450 2E1. Role of H2O2 and cyclooxygenase-2.
The Journal of biological chemistry 2000;275(26):20136-45.
2000: Bai J; Cederbaum A I
Overexpression of catalase in the mitochondrial or cytosolic compartment increases sensitivity of HepG2 cells to tumor necrosis factor-alpha-induced apoptosis.
The Journal of biological chemistry 2000;275(25):19241-9.
2000: Marí M; Cederbaum A I
CYP2E1 overexpression in HepG2 cells induces glutathione synthesis by transcriptional activation of gamma-glutamylcysteine synthetase.
The Journal of biological chemistry 2000;275(20):15563-71.
2000: Wu D; Cederbaum A I
Ethanol and arachidonic acid produce toxicity in hepatocytes from pyrazole-treated rats with high levels of CYP2E1.
Molecular and cellular biochemistry 2000;204(1-2):157-67.
1999: Goasduff T; Cederbaum A I
NADPH-dependent microsomal electron transfer increases degradation of CYP2E1 by the proteasome complex: role of reactive oxygen species.
Archives of biochemistry and biophysics 1999;370(2):258-70.
1999: Nieto N; Friedman S L; Greenwel P; Cederbaum A I
CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells.
Hepatology (Baltimore, Md.) 1999;30(4):987-96.
1999: Bai J; Rodriguez A M; Melendez J A; Cederbaum A I
Overexpression of catalase in cytosolic or mitochondrial compartment protects HepG2 cells against oxidative injury.
The Journal of biological chemistry 1999;274(37):26217-24.
1999: Stoyanovsky D A; Cederbaum A I
Metabolism of carbon tetrachloride to trichloromethyl radical: An ESR and HPLC-EC study.
Chemical research in toxicology 1999;12(8):730-6.
1999: Stoyanovsky D A; Cederbaum A I
Metabolites of acetaminophen trigger Ca2+ release from liver microsomes.
Toxicology letters 1999;106(1):23-9.
1999: Stoyanovsky D A; Melnikov Z; Cederbaum A I
ESR and HPLC-EC analysis of the interaction of hydroxyl radical with DMSO: rapid reduction and quantification of POBN and PBN nitroxides.
Analytical chemistry 1999;71(3):715-21.
1999: Wu D; Cederbaum A I
Ethanol-induced apoptosis to stable HepG2 cell lines expressing human cytochrome P-4502E1.
Alcoholism, clinical and experimental research 1999;23(1):67-76.
1998: Sakurai K; Cederbaum A I
Oxidative stress and cytotoxicity induced by ferric-nitrilotriacetate in HepG2 cells that express cytochrome P450 2E1.
Molecular pharmacology 1998;54(6):1024-35.
1998: Stoyanovsky D A; Cederbaum A I
ESR and HPLC-EC analysis of ethanol oxidation to 1-hydroxyethyl radical: rapid reduction and quantification of POBN and PBN nitroxides.
Free radical biology & medicine 1998;25(4-5):536-45.
1998: Chen Q; Galleano M; Cederbaum A I
Cytotoxicity and apoptosis produced by arachidonic acid in HepG2 cells overexpressing human cytochrome P-4502E1.
Alcoholism, clinical and experimental research 1998;22(4):782-4.
1998: Cederbaum A I
Use of transduced cell lines in studies on alcohol metabolism and toxicity. Introduction to the symposium.
Alcoholism, clinical and experimental research 1998;22(4):777.
1998: Chen Q; Cederbaum A I
Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells.
Molecular pharmacology 1998;53(4):638-48.
1998: Stoyanovsky D A; Cederbaum A I
Redox-cycling of iron ions triggers calcium release from liver microsomes.
Free radical biology & medicine 1998;24(5):745-53.
1998: Stoyanovsky D A; Wu D; Cederbaum A I
Interaction of 1-hydroxyethyl radical with glutathione, ascorbic acid and alpha-tocopherol.
Free radical biology & medicine 1998;24(1):132-8.
1998: Cederbaum A I
Ethanol-related cytotoxicity catalyzed by CYP2E1-dependent generation of reactive oxygen intermediates in transduced HepG2 cells.
BioFactors (Oxford, England) 1998;8(1-2):93-6.
1997: Gergel' D; Cederbaum A I
Interaction of nitric oxide with 2-thio-5-nitrobenzoic acid: implications for the determination of free sulfhydryl groups by Ellman's reagent.
Archives of biochemistry and biophysics 1997;347(2):282-8.
1997: Chen Q; Cederbaum A I
Menadione cytotoxicity to Hep G2 cells and protection by activation of nuclear factor-kappaB.
Molecular pharmacology 1997;52(4):648-57.
1997: Wu D; Ramin S A; Cederbaum A I
Effect of pyridine on the expression of cytochrome P450 isozymes in primary rat hepatocyte culture.
Molecular and cellular biochemistry 1997;173(1-2):103-11.
1997: Chen Q; Galleano M; Cederbaum A I
Cytotoxicity and apoptosis produced by arachidonic acid in Hep G2 cells overexpressing human cytochrome P4502E1.
The Journal of biological chemistry 1997;272(23):14532-41.
1997: Yang M X; Cederbaum A I
Characterization of cytochrome P4502E1 turnover in transfected HepG2 cells expressing human CYP2E1.
Archives of biochemistry and biophysics 1997;341(1):25-33.
1997: Yang M X; Cederbaum A I
Glycerol increases content and activity of human cytochrome P-4502E1 in a transduced HepG2 cell line by protein stabilization.
Alcoholism, clinical and experimental research 1997;21(2):340-7.
1997: Gergel D; Misík V; Riesz P; Cederbaum A I
Inhibition of rat and human cytochrome P4502E1 catalytic activity and reactive oxygen radical formation by nitric oxide.
Archives of biochemistry and biophysics 1997;337(2):239-50.
1997: Rao D N; Cederbaum A I
A comparative study of the redox-cycling of a quinone (rifamycin S) and a quinonimine (rifabutin) antibiotic by rat liver microsomes.
Free radical biology & medicine 1997;22(3):439-46.
1996: Gergel D; Cederbaum A I
Inhibition of the catalytic activity of alcohol dehydrogenase by nitric oxide is associated with S nitrosylation and the release of zinc.
Biochemistry 1996;35(50):16186-94.
1996: Stoyanovsky D A; Cederbaum A I
Thiol oxidation and cytochrome P450-dependent metabolism of CCl4 triggers Ca2+ release from liver microsomes.
Biochemistry 1996;35(49):15839-45.
1996: Yang M X; Cederbaum A I
Role of the proteasome complex in degradation of human CYP2E1 in transfected HepG2 cells.
Biochemical and biophysical research communications 1996;226(3):711-6.
1996: Wu D; Cederbaum A I
Ethanol cytotoxicity to a transfected HepG2 cell line expressing human cytochrome P4502E1.
The Journal of biological chemistry 1996;271(39):23914-9.
1996: Kukielka E; Cederbaum A I
Ferritin stimulation of lipid peroxidation by microsomes after chronic ethanol treatment: role of cytochrome P4502E1.
Archives of biochemistry and biophysics 1996;332(1):121-7.
1996: Rao D N; Yang M X; Lasker J M; Cederbaum A I
1-Hydroxyethyl radical formation during NADPH- and NADH-dependent oxidation of ethanol by human liver microsomes.
Molecular pharmacology 1996;49(5):814-21.
1996: Wu D; Cederbaum A I
Expression of cytochrome P4502E1 in rat fetal hepatocyte culture.
Molecular pharmacology 1996;49(5):802-7.
1996: Ramakrishna Rao D N; Cederbaum A I
Generation of reactive oxygen species by the redox cycling of nitroprusside.
Biochimica et biophysica acta 1996;1289(2):195-202.
1995: Yang M X; Cederbaum A I
Role of cytochrome b5 in NADH-dependent microsomal reduction of ferric complexes, lipid peroxidation, and hydrogen peroxide generation.
Archives of biochemistry and biophysics 1995;324(2):282-92.
1995: Dai Y; Cederbaum A I
Inactivation and degradation of human cytochrome P4502E1 by CCl4 in a transfected HepG2 cell line.
The Journal of pharmacology and experimental therapeutics 1995;275(3):1614-22.
1995: Kukielka E; Cederbaum A I
Increased production of hydroxyl radical by pericentral microsomes compared to periportal microsomes after pyrazole induction of cytochrome P4502E1.
Biochemical and biophysical research communications 1995;215(2):698-705.
1995: Gergel D; Misík V; Ondrias K; Cederbaum A I
Increased cytotoxicity of 3-morpholinosydnonimine to HepG2 cells in the presence of superoxide dismutase. Role of hydrogen peroxide and iron.
The Journal of biological chemistry 1995;270(36):20922-9.
1995: Rao D N; Cederbaum A I
Production of nitric oxide and other iron-containing metabolites during the reductive metabolism of nitroprusside by microsomes and by thiols.
Archives of biochemistry and biophysics 1995;321(2):363-71.
1995: Dai Y; Cederbaum A I
Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfected HepG2 cells.
The Journal of pharmacology and experimental therapeutics 1995;273(3):1497-505.
1995: Kukielka E; Cederbaum A I
Increased oxidation of ethylene glycol to formaldehyde by microsomes after ethanol treatment: role of oxygen radicals and cytochrome P450.
Toxicology letters 1995;78(1):9-15.
1995: Kukielka E; Cederbaum A I
Stimulation of NADH-dependent microsomal DNA strand cleavage by rifamycin SV.
The Biochemical journal 1995;307 ( Pt 2)():361-7.
1995: Kringstein P; Cederbaum A I
Boldine prevents human liver microsomal lipid peroxidation and inactivation of cytochrome P4502E1.
Free radical biology & medicine 1995;18(3):559-63.
1994: Yang M X; Cederbaum A I
Fractionation of liver microsomes with polyethylene glycol and purification of NADH-cytochrome b5 oxidoreductase and cytochrome b5.
Archives of biochemistry and biophysics 1994;315(2):438-44.
1994: Kukielka E; Cederbaum A I
DNA strand cleavage as a sensitive assay for the production of hydroxyl radicals by microsomes: role of cytochrome P4502E1 in the increased activity after ethanol treatment.
The Biochemical journal 1994;302 ( Pt 3)():773-9.
1994: Carroccio A; Wu D; Cederbaum A I
Ethanol increases content and activity of human cytochrome P4502E1 in a transduced HepG2 cell line.
Biochemical and biophysical research communications 1994;203(1):727-33.
1994: Rashba-Step J; Step E; Turro N J; Cederbaum A I
Oxidation of glycerol to formaldehyde by microsomes: are glycerol radicals produced in the reaction pathway?
Biochemistry 1994;33(32):9504-10.
1994: Wu D; Cederbaum A I
Characterization of pyrazole and 4-methylpyrazole induction of cytochrome P4502E1 in rat kidney.
The Journal of pharmacology and experimental therapeutics 1994;270(1):407-13.
1994: Kukielka E; Dicker E; Cederbaum A I
Increased production of reactive oxygen species by rat liver mitochondria after chronic ethanol treatment.
Archives of biochemistry and biophysics 1994;309(2):377-86.
1994: Kukielka E; Cederbaum A I
Ferritin stimulation of hydroxyl radical production by rat liver nuclei.
Archives of biochemistry and biophysics 1994;308(1):70-7.
1994: Rashba-Step J; Cederbaum A I
Generation of reactive oxygen intermediates by human liver microsomes in the presence of NADPH or NADH.
Molecular pharmacology 1994;45(1):150-7.
1993: Clejan L A; Cederbaum A I
Stimulation by paraquat of microsomal and cytochrome P-450-dependent oxidation of glycerol to formaldehyde.
The Biochemical journal 1993;295 ( Pt 3)():781-6.
1993: Wu D; Cederbaum A I
Ethanol consumption by the nursing mother induces cytochrome P-4502E1 in neonatal rat liver.
The Journal of pharmacology and experimental therapeutics 1993;267(1):560-6.
1993: Dicker E; Cederbaum A I
Requirement for iron for the production of hydroxyl radicals by rat liver quinone reductase.
The Journal of pharmacology and experimental therapeutics 1993;266(3):1282-90.
1993: Dai Y; Rashba-Step J; Cederbaum A I
Stable expression of human cytochrome P4502E1 in HepG2 cells: characterization of catalytic activities and production of reactive oxygen intermediates.
Biochemistry 1993;32(27):6928-37.
1993: Wu D; Cederbaum A I
Combined effects of streptozotocin-induced diabetes plus 4-methylpyrazole treatment on rat liver cytochrome P4502E1.
Archives of biochemistry and biophysics 1993;302(1):175-82.
1993: Wu D; Cederbaum A I
Induction of liver cytochrome P4502E1 by pyrazole and 4-methylpyrazole in neonatal rats.
The Journal of pharmacology and experimental therapeutics 1993;264(3):1468-73.
1993: Rashba-Step J; Turro N J; Cederbaum A I
Increased NADPH- and NADH-dependent production of superoxide and hydroxyl radical by microsomes after chronic ethanol treatment.
Archives of biochemistry and biophysics 1993;300(1):401-8.
1993: Rashba-Step J; Turro N J; Cederbaum A I
ESR studies on the production of reactive oxygen intermediates by rat liver microsomes in the presence of NADPH or NADH.
Archives of biochemistry and biophysics 1993;300(1):391-400.
1992: Winters D K; Cederbaum A I
Expression of a catalytically active human cytochrome P-4502E1 in Escherichia coli.
Biochimica et biophysica acta 1992;1156(1):43-9.
1992: Cederbaum A I; Kukielka E; Speisky H
Inhibition of rat liver microsomal lipid peroxidation by boldine.
Biochemical pharmacology 1992;44(9):1765-72.
1992: Kukielka E; Cederbaum A I
Stimulation of microsomal production of reactive oxygen intermediates by rifamycin SV: effect of ferric complexes and comparisons between NADPH and NADH.
Archives of biochemistry and biophysics 1992;298(2):602-11.
1992: Clejan L A; Cederbaum A I
Structural determinants for alcohol substrates to be oxidized to formaldehyde by rat liver microsomes.
Archives of biochemistry and biophysics 1992;298(1):105-13.
1992: Winters D K; Cederbaum A I
Time course characterization of the induction of cytochrome P-450 2E1 by pyrazole and 4-methylpyrazole.
Biochimica et biophysica acta 1992;1117(1):15-24.
1992: Kukielka E; Cederbaum A I
The effect of chronic ethanol consumption on NADH- and NADPH-dependent generation of reactive oxygen intermediates by isolated rat liver nuclei.
Alcohol and alcoholism (Oxford, Oxfordshire) 1992;27(3):233-9.
1992: Wu D; Cederbaum A I
Presence of functionally active cytochrome P-450IIE1 in the plasma membrane of rat hepatocytes.
Hepatology (Baltimore, Md.) 1992;15(3):515-24.
1992: Puntarulo S; Cederbaum A I
Effect of phenobarbital and 3-methylcholanthrene treatment on NADPH- and NADH-dependent production of reactive oxygen intermediates by rat liver nuclei.
Biochimica et biophysica acta 1992;1116(1):17-23.
1992: Dicker E; Cederbaum A I
Increased NADH-dependent production of reactive oxygen intermediates by microsomes after chronic ethanol consumption: comparisons with NADPH.
Archives of biochemistry and biophysics 1992;293(2):274-80.
1992: Winters D K; Cederbaum A I
The content and activity of cytochrome P450 2E1 in liver microsomes from alcohol-preferring and non-preferring rats.
Alcohol and alcoholism (Oxford, Oxfordshire) 1992;27(1):63-70.
1992: Clejan L A; Cederbaum A I
Role of cytochrome P450 in the oxidation of glycerol by reconstituted systems and microsomes.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(2):765-70.
1991: Dicker E; Cederbaum A I
Increased oxidation of dimethylnitrosamine in pericentral microsomes after pyrazole induction of cytochrome P-4502E1.
Alcoholism, clinical and experimental research 1991;15(6):1072-6.
1991: Kukielka E; Cederbaum A I
Oxidation of ethylene glycol to formaldehyde by rat liver microsomes. Role of cytochrome P-450 and reactive oxygen species.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(6):1108-15.
1991: Dicker E; Cederbaum A I
NADH-dependent generation of reactive oxygen species by microsomes in the presence of iron and redox cycling agents.
Biochemical pharmacology 1991;42(3):529-35.
1991: Dicker E; McHugh T; Cederbaum A I
Increased catalytic activity of cytochrome P-450IIE1 in pericentral hepatocytes compared to periportal hepatocytes isolated from pyrazole-treated rats.
Biochimica et biophysica acta 1991;1073(2):316-23.
1991: Clejan L A; Cederbaum A I
Role of iron, hydrogen peroxide and reactive oxygen species in microsomal oxidation of glycerol to formaldehyde.
Archives of biochemistry and biophysics 1991;285(1):83-9.
1991: Cederbaum A I
Microsomal generation of reactive oxygen species and their possible role in alcohol hepatotoxicity.
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement 1991;1():291-6.
1990: Kukielka E; Cederbaum A I
NADPH- and NADH-dependent oxygen radical generation by rat liver nuclei in the presence of redox cycling agents and iron.
Archives of biochemistry and biophysics 1990;283(2):326-33.
1990: Wu D F; Clejan L; Potter B; Cederbaum A I
Rapid decrease of cytochrome P-450IIE1 in primary hepatocyte culture and its maintenance by added 4-methylpyrazole.
Hepatology (Baltimore, Md.) 1990;12(6):1379-89.
1990: Dicker E; McHugh T; Cederbaum A I
Increased oxidation of p-nitrophenol and aniline by intact hepatocytes isolated from pyrazole-treated rats.
Biochimica et biophysica acta 1990;1035(3):249-56.
1990: Clejan L A; Cederbaum A I
Comparison of the interaction of pyrazole and its metabolite 4-hydroxypyrazole with rat liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(4):393-7.
1990: Clejan L A; Cederbaum A I
Oxidation of pyrazole by reconstituted systems containing cytochrome P-450 IIE1.
Biochimica et biophysica acta 1990;1034(2):233-7.
1990: Dicker E; Cederbaum A I
Generation of reactive oxygen species and reduction of ferric chelates by microsomes in the presence of a reconstituted system containing ethanol, NAD+ and alcohol dehydrogenase.
Alcoholism, clinical and experimental research 1990;14(2):238-44.
1990: Winters D K; Cederbaum A I
Oxidation of glycerol to formaldehyde by rat liver microsomes. Effects of cytochrome P-450 inducing agents.
Biochemical pharmacology 1990;39(4):697-705.
1989: Kukielka E; Cederbaum A I
NADH-dependent microsomal interaction with ferric complexes and production of reactive oxygen intermediates.
Archives of biochemistry and biophysics 1989;275(2):540-50.
1989: Clejan L A; Koop D R; Cederbaum A I
Sensitivity of the rat liver microsomal oxidation of pyrazole to antibody raised against the ethanol-inducible rabbit liver cytochrome P-450 isozyme.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(6):694-8.
1989: Feierman D E; Cederbaum A I
Role of cytochrome P-450 IIE1 and catalase in the oxidation of acetonitrile to cyanide.
Chemical research in toxicology 1989;2(6):359-66.
1989: Kukielka E; Puntarulo S; Cederbaum A I
Interaction of ferric complexes with rat liver nuclei to catalyze NADH-and NADPH-Dependent production of oxygen radicals.
Archives of biochemistry and biophysics 1989;273(2):319-30.
1989: Puntarulo S; Cederbaum A I
Interactions between paraquat and ferric complexes in the microsomal generation of oxygen radicals.
Biochemical pharmacology 1989;38(17):2911-8.
1989: Clejan L; Cederbaum A I
Synergistic interactions between NADPH-cytochrome P-450 reductase, paraquat, and iron in the generation of active oxygen radicals.
Biochemical pharmacology 1989;38(11):1779-86.
1989: Puntarulo S; Cederbaum A I
Temperature dependence of the microsomal oxidation of ethanol by cytochrome P450 and hydroxyl radical-dependent reactions.
Archives of biochemistry and biophysics 1989;269(2):569-75.
1989: Puntarulo S; Cederbaum A I
Chemiluminescence from acetaldehyde oxidation by xanthine oxidase involves generation of and interactions with hydroxyl radicals.
Alcoholism, clinical and experimental research 1989;13(1):84-90.
1989: Cederbaum A I
Role of lipid peroxidation and oxidative stress in alcohol toxicity.
Free radical biology & medicine 1989;7(5):537-9.
1989: Cederbaum A I
Oxygen radical generation by microsomes: role of iron and implications for alcohol metabolism and toxicity.
Free radical biology & medicine 1989;7(5):559-67.
1989: Puntarulo S; Turrens J F; Cederbaum A I
Oxygen-concentration dependence of microsomal chemiluminescence.
Free radical biology & medicine 1989;7(3):269-73.
1988: Puntarulo S; Cederbaum A I
Increased NADPH-dependent chemiluminescence by microsomes after chronic ethanol consumption.
Archives of biochemistry and biophysics 1988;266(2):435-45.
1988: Dicker E; Cederbaum A I
Increased oxygen radical-dependent inactivation of metabolic enzymes by liver microsomes after chronic ethanol consumption.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1988;2(13):2901-6.
1988: Puntarulo S; Cederbaum A I
Comparison of the ability of ferric complexes to catalyze microsomal chemiluminescence, lipid peroxidation, and hydroxyl radical generation.
Archives of biochemistry and biophysics 1988;264(2):482-91.
1988: Winters D K; Clejan L A; Cederbaum A I
Oxidation of glycerol to formaldehyde by rat liver microsomes.
Biochemical and biophysical research communications 1988;153(2):612-7.
1988: Puntarulo S; Cederbaum A I
Effect of oxygen concentration on microsomal oxidation of ethanol and generation of oxygen radicals.
The Biochemical journal 1988;251(3):787-94.
1988: Puntarulo S; Cederbaum A I
Oxidation of pyrazole to 4-hydroxypyrazole by intact rat hepatocytes.
Biochemical pharmacology 1988;37(8):1555-61.
1988: Palakodety R B; Clejan L A; Krikun G; Feierman D E; Cederbaum A I
Characterization and identification of a pyrazole-inducible form of cytochrome P-450.
The Journal of biological chemistry 1988;263(2):878-84.
1988: Puntarulo S; Cederbaum A I
Increased microsomal interaction with iron and oxygen radical generation after chronic acetone treatment.
Biochimica et biophysica acta 1988;964(1):46-52.
1987: Puntarulo S; Cederbaum A I
Chemiluminescence studies on the generation of oxygen radicals from the interaction of NADPH-cytochrome P-450 reductase with iron.
Archives of biochemistry and biophysics 1987;258(2):510-8.
1987: Feierman D E; Cederbaum A I
Increased sensitivity of the microsomal oxidation of ethanol to inhibition by pyrazole and 4-methylpyrazole after chronic ethanol treatment.
Biochemical pharmacology 1987;36(19):3277-83.
1987: Feierman D E; Cederbaum A I
Oxidation of the alcohol dehydrogenase inhibitor pyrazole to 4-hydroxypyrazole by microsomes. Effect of cytochrome P-450 inducing agents.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(5):634-9.
1986: Krikun G; Feierman D E; Cederbaum A I
Rat liver microsomal induction of the oxidation of drugs and alcohols, and sodium dodecyl sulfate-gel profiles after in vivo treatment with pyrazole or 4-methylpyrazole.
The Journal of pharmacology and experimental therapeutics 1986;237(3):1012-9.

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