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Eugene Eyo Akujuru

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Paul A Beavis; Parisa Amjadi; Adam P Cribbs; Eugene Eyo Akujuru; Patricia Green; Bernard Gregory; Alan Kennedy; Andrew C Palfreeman; Fionula M Brennan
Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells.
Anna K Andersson; Henrik Agersø; David Ahern; Parisa Amjadi; Chiwen Chang; Eugene Eyo Akujuru; Claus Haase; Fiona E McCann; Kay McNamee; Vibeke W Stennicke; Percy F Sumariwalla; Ditte Tornehave; John Trowsdale; Birgitte Uraø; Fionula M Brennan
Blockade of NKG2D ameliorates disease in mice with collagen-induced arthritis: a potential pathogenic role in chronic inflammatory arthritis.
Kay E McNamee; Richard O Williams; Saba Alzabin; Praveen Anand; Eugene Eyo Akujuru; Jane P Hughes; Julia J Inglis
IL-17 induces hyperalgesia via TNF-dependent neutrophil infiltration.

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2011: Paul A Beavis; Parisa Amjadi; Adam P Cribbs; Eugene Eyo Akujuru; Patricia Green; Bernard Gregory; Alan Kennedy; Andrew C Palfreeman; Fionula M Brennan
Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(40):16717-22.
2011: Anna K Andersson; Henrik Agersø; David Ahern; Parisa Amjadi; Chiwen Chang; Eugene Eyo Akujuru; Claus Haase; Fiona E McCann; Kay McNamee; Vibeke W Stennicke; Percy F Sumariwalla; Ditte Tornehave; John Trowsdale; Birgitte Uraø; Fionula M Brennan
Blockade of NKG2D ameliorates disease in mice with collagen-induced arthritis: a potential pathogenic role in chronic inflammatory arthritis.
Arthritis and rheumatism 2011;63(9):2617-29.
2011: Kay E McNamee; Richard O Williams; Saba Alzabin; Praveen Anand; Eugene Eyo Akujuru; Jane P Hughes; Julia J Inglis
IL-17 induces hyperalgesia via TNF-dependent neutrophil infiltration.
Pain 2011;152(8):1838-45.
2011: Thomas Krausgruber; Katrina Blazek; Timothy Smallie; Saba Alzabin; Helen Lockstone; Natasha Sahgal; Tracy Hussell; Eugene Eyo Akujuru; Irina A Udalova
IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses.
Nature immunology 2011;12(3):231-8.
2011: Jennifer E Cole; Tina J Navin; Amanda J Cross; Michael E Goddard; Lena Alexopoulou; Anuja T Mitra; Alun H Davies; Richard A Flavell; Eugene Eyo Akujuru; Claudia Monaco
Unexpected protective role for Toll-like receptor 3 in the arterial wall.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(6):2372-7.
2011: Graeme E Glass; James K Chan; Andrew Freidin; Eugene Eyo Akujuru; Nicole J Horwood; Jagdeep Nanchahal
TNF-alpha promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(4):1585-90.
2010: Nasser M Malik; Pei Jin; Yvonne Raatz; Percy F Sumariwalla; Serafim Kiriakidis; Michael Shepard; Eugene Eyo Akujuru; Ewa Paleolog
Regulation of the angiopoietin-Tie ligand-receptor system with a novel splice variant of Tie1 reduces the severity of murine arthritis.
Rheumatology (Oxford, England) 2010;49(10):1828-39.
2010: Tim Smallie; Giuseppe Ricchetti; Nicole J Horwood; Eugene Eyo Akujuru; Andrew R Clark; Lynn M Williams
IL-10 inhibits transcription elongation of the human TNF gene in primary macrophages.
The Journal of experimental medicine 2010;207(10):2081-8.
2010: Theresa H Page; Jeremy J O Turner; Anthony C Brown; Emma M Timms; Julia J Inglis; Fionula M Brennan; Brian M J Foxwell; Keith P Ray; Eugene Eyo Akujuru
Nonsteroidal anti-inflammatory drugs increase TNF production in rheumatoid synovial membrane cultures and whole blood.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(6):3694-701.
2010: Stefan K Drexler; Philip Kong; Julia Inglis; Richard O Williams; Cecilia Garlanda; Alberto Mantovani; Amir S Yazdi; Fionula Brennan; Eugene Eyo Akujuru; Brian M J Foxwell
SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis.
Arthritis and rheumatism 2010;62(8):2249-61.
2010: Ling Weng; Richard O Williams; Pedro L Vieira; Gavin Screaton; Eugene Eyo Akujuru; Francesco Dazzi
The therapeutic activity of low-dose irradiation on experimental arthritis depends on the induction of endogenous regulatory T cell activity.
Annals of the rheumatic diseases 2010;69(8):1519-26.
2010: Eugene Eyo Akujuru; Ravinder N Maini
Anti-TNF therapy, from rationale to standard of care: what lessons has it taught us?
Journal of immunology (Baltimore, Md. : 1950) 2010;185(2):791-4.
2010: S K Drexler; J Wales; Evangelos Andreakos; P Kong; A Davis; C Garlanda; A Mantovani; T Hussell; Eugene Eyo Akujuru; B M J Foxwell
Evidence for a DC-specific inhibitory mechanism that depends on MyD88 and SIGIRR.
Scandinavian journal of immunology 2010;71(6):393-402.
2010: Kay E McNamee; Annika Burleigh; Luke L Gompels; Eugene Eyo Akujuru; Shelley J Allen; Richard O Williams; David Dawbarn; Tonia L Vincent; Julia J Inglis
Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain.
Pain 2010;149(2):386-92.
2010: Fiona E McCann; Andrew C Palfreeman; Melanie Andrews; Dany P Perocheau; Julia J Inglis; Peter Schafer; Eugene Eyo Akujuru; Richard O Williams; Fionula M Brennan
Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.
Arthritis research & therapy 2010;12(3):R107.
2010: Niccolò Terrando; António Rei Fidalgo; Marcela Vizcaychipi; Mario Cibelli; Daqing Ma; Claudia Monaco; Eugene Eyo Akujuru; Mervyn Maze
The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction.
Critical care (London, England) 2010;14(3):R88.
2010: Natalia Wegner; Karin Lundberg; Andrew Kinloch; Benjamin Fisher; Vivianne Malmström; Eugene Eyo Akujuru; Patrick J Venables
Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis.
Immunological reviews 2010;233(1):34-54.
2010: Eugene Eyo Akujuru; R O Williams; Ewa Paleolog
What have we learnt from targeted anti-TNF therapy?
Annals of the rheumatic diseases 2010;69 Suppl 1():i97-99.
2009: Claudia Monaco; Scott M Gregan; Tina J Navin; Brian M J Foxwell; Alun H Davies; Eugene Eyo Akujuru
Toll-like receptor-2 mediates inflammation and matrix degradation in human atherosclerosis.
Circulation 2009;120(24):2462-9.
2009: Philippa Hillyer; Mark Larché; Edward P Bowman; Terrill K McClanahan; Rene de Waal Malefyt; Lauren P Schewitz; Grey Giddins; Eugene Eyo Akujuru; Robert A Kastelein; Fionula M Brennan
Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis.
Rheumatology (Oxford, England) 2009;48(12):1581-9.
2009: Eugene Eyo Akujuru
A view from a European medical academic who spends time in the US.
The Journal of clinical investigation 2009;119(10):2861-2.
2009: Peter C Taylor; Eugene Eyo Akujuru
Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis.
Nature reviews. Rheumatology 2009;5(10):578-82.
2009: Chiara Gasparini; Brian M J Foxwell; Eugene Eyo Akujuru
RelB/p50 regulates CCL19 production, but fails to promote human DC maturation.
European journal of immunology 2009;39(8):2215-23.
2009: Fionula Brennan; Eugene Eyo Akujuru
In memoriam: Professor Brian Maurice John Foxwell, 1956 to 2008.
Arthritis research & therapy 2009;11(1):104.
2009: Percy F Sumariwalla; C D Palmer; L B Pickford; Eugene Eyo Akujuru; Brian M J Foxwell; Fionula M Brennan
Suppression of tumour necrosis factor production from mononuclear cells by a novel synthetic compound, CLX-090717.
Rheumatology (Oxford, England) 2009;48(1):32-8.
2009: Eugene Eyo Akujuru
Translating molecular insights in autoimmunity into effective therapy.
Annual review of immunology 2009;27():1-27.
2008: Sandra M Sacre; Alexandra Lo; Bernard Gregory; Rachel E Simmonds; Lynn Williams; Eugene Eyo Akujuru; Fionula M Brennan; Brian M J Foxwell
Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(11):8002-9.
2008: Eugene Eyo Akujuru
Many cytokines are very useful therapeutic targets in disease.
The Journal of clinical investigation 2008;118(11):3533-6.
2008: Percy F Sumariwalla; Pei Jin; Juan Zhang; Irene Ni; Damian Crawford; H Michael Shepard; Ewa Paleolog; Eugene Eyo Akujuru
Antagonism of the human epidermal growth factor receptor family controls disease severity in murine collagen-induced arthritis.
Arthritis and rheumatism 2008;58(10):3071-80.
2008: Julia J Inglis; Kay E McNamee; Shi-Lu Chia; David Essex; Eugene Eyo Akujuru; Richard O Williams; Stephen P Hunt; Tonia L Vincent
Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system.
Arthritis and rheumatism 2008;58(10):3110-9.
2008: A K Andersson; Eugene Eyo Akujuru; Fionula M Brennan
Neutralizing IL-21 and IL-15 inhibits pro-inflammatory cytokine production in rheumatoid arthritis.
Scandinavian journal of immunology 2008;68(1):103-11.
2008: Eugene Eyo Akujuru; Sir Ravinder N Maini
Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics.
Immunological reviews 2008;223():7-19.
2008: Lynn M Williams; Ferdinand Lali; Kate Willetts; Cristina Balague; Nuria Godessart; Fionula Brennan; Eugene Eyo Akujuru; Brian M J Foxwell
Rac mediates TNF-induced cytokine production via modulation of NF-kappaB.
Molecular immunology 2008;45(9):2446-54.
2008: Egle Simelyte; Gabriel Criado; David Essex; Robert A Uger; Eugene Eyo Akujuru; Richard O Williams
CD200-Fc, a novel antiarthritic biologic agent that targets proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis.
Arthritis and rheumatism 2008;58(4):1038-43.
2008: Michael J Elliot; Ravinder N Maini; Eugene Eyo Akujuru; Alice Long-Fox; Peter Charles; Peter Katasikis; Fionula M Brennan; Hanny Bijl; John Ghrayeb; James N Woody
Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha.
Arthritis and rheumatism 2008;58(2 Suppl):S92-S101.
2008: Pei Jin; Juan Zhang; Percy F Sumariwalla; Irene Ni; Brett Jorgensen; Damian Crawford; Suzanne Phillips; Eugene Eyo Akujuru; H Michael Shepard; Ewa M Paleolog
Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.
Arthritis research & therapy 2008;10(4):R73.
2008: Fionula M Brennan; Nicola M G Smith; Sally Owen; Ching Li; Parisa Amjadi; Patricia Green; Anna Andersson; Andrew C Palfreeman; Philippa Hillyer; Andrew D Foey; Jonathan T Beech; Eugene Eyo Akujuru
Resting CD4+ effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function.
Arthritis research & therapy 2008;10(2):R36.
2007: Julia J Inglis; Clare A Notley; David Essex; Alex W Wilson; Eugene Eyo Akujuru; Praveen Anand; Richard Williams
Collagen-induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade.
Arthritis and rheumatism 2007;56(12):4015-23.
2007: Jeremy Wales; Evangelos Andreakos; Eugene Eyo Akujuru; Brian M J Foxwell
Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination.
Biochemical Society transactions 2007;35(Pt 6):1501-3.
2007: Sandra M Sacre; Stefan K Drexler; Evangelos Andreakos; Eugene Eyo Akujuru; Fionula M Brennan; Brian M J Foxwell
Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue.
Annals of the rheumatic diseases 2007;66 Suppl 3():iii81-6.
2007: Anna M C Lundberg; Stefan K Drexler; Claudia Monaco; Lynn M Williams; Sandra M Sacre; Eugene Eyo Akujuru; Brian M J Foxwell
Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems.
Blood 2007;110(9):3245-52.
2007: Julia J Inglis; G Criado; M Andrews; Eugene Eyo Akujuru; Richard O Williams; M L Selley
The anti-allergic drug, N-(3',4'-dimethoxycinnamonyl) anthranilic acid, exhibits potent anti-inflammatory and analgesic properties in arthritis.
Rheumatology (Oxford, England) 2007;46(9):1428-32.
2007: Richard O Williams; Ewa Paleolog; Eugene Eyo Akujuru
Cytokine inhibitors in rheumatoid arthritis and other autoimmune diseases.
Current opinion in pharmacology 2007;7(4):412-7.
2007: Abdulmunem Sheryanna; Gurjeet Bhangal; John P McDaid; Jennifer Smith; Anthony Manning; Brian M J Foxwell; Eugene Eyo Akujuru; H Terence Cook; Charles D Pusey; Frederick W K Tam
Inhibition of p38 mitogen-activated protein kinase is effective in the treatment of experimental crescentic glomerulonephritis and suppresses monocyte chemoattractant protein-1 but not IL-1beta or IL-6.
Journal of the American Society of Nephrology : JASN 2007;18(4):1167-79.
2007: Sandra M Sacre; Anna M C Lundberg; Evangelos Andreakos; Corinne Taylor; Eugene Eyo Akujuru; Brian M J Foxwell
Selective use of TRAM in lipopolysaccharide (LPS) and lipoteichoic acid (LTA) induced NF-kappaB activation and cytokine production in primary human cells: TRAM is an adaptor for LPS and LTA signaling.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2148-54.
2007: Sandra M Sacre; Evangelos Andreakos; Serafim Kiriakidis; Parisa Amjadi; Anna M C Lundberg; Grey Giddins; Eugene Eyo Akujuru; Fionula Brennan; Brian M J Foxwell
The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis.
The American journal of pathology 2007;170(2):518-25.
2007: Julia J Inglis; Gabriel Criado; Mino Medghalchi; Melanie Andrews; Ann Sandison; Eugene Eyo Akujuru; Richard O Williams
Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen.
Arthritis research & therapy 2007;9(5):R113.
2007: Christopher J Edwards; Jeffrey L Feldman; Jonathan Beech; Kathleen M Shields; Jennifer A Stover; William L Trepicchio; Glenn Larsen; Brian Mj Foxwell; Fionula M Brennan; Eugene Eyo Akujuru; Debra D Pittman
Molecular profile of peripheral blood mononuclear cells from patients with rheumatoid arthritis.
Molecular medicine (Cambridge, Mass.) 2007;13(1-2):40-58.
2006: Evangelos Andreakos; R O Williams; Jeremy Wales; Brian M J Foxwell; Eugene Eyo Akujuru
Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(39):14459-64.
2006: Eugene Eyo Akujuru; Charles D Pusey
Is there a role for TNF-alpha in anti-neutrophil cytoplasmic antibody-associated vasculitis? Lessons from other chronic inflammatory diseases.
Journal of the American Society of Nephrology : JASN 2006;17(5):1243-52.
2006: Jennifer Grosjean; Serafim Kiriakidis; Kerri Reilly; Eugene Eyo Akujuru; Ewa Paleolog
Vascular endothelial growth factor signalling in endothelial cell survival: a role for NFkappaB.
Biochemical and biophysical research communications 2006;340(3):984-94.
2006: Fionula M Brennan; Andrew D Foey; Eugene Eyo Akujuru
The importance of T cell interactions with macrophages in rheumatoid cytokine production.
Current topics in microbiology and immunology 2006;305():177-94.
2005: Sandra M Sacre; Evangelos Andreakos; Peter Taylor; Eugene Eyo Akujuru; Brian M J Foxwell
Molecular therapeutic targets in rheumatoid arthritis.
Expert reviews in molecular medicine 2005;7(16):1-20.
2005: Eugene Eyo Akujuru; Lawrence Steinman
Design of effective immunotherapy for human autoimmunity.
Nature 2005;435(7042):612-9.
2005: Eugene Eyo Akujuru; Fionula M Brennan; Brian M J Foxwell; Peter C Taylor; Richard O Williams; R N Maini
Anti-TNF therapy: where have we got to in 2005?
Journal of autoimmunity 2005;25 Suppl():26-8.
2005: Evangelos Andreakos; Sandra M Sacre; Brian M J Foxwell; Eugene Eyo Akujuru
The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis.
Frontiers in bioscience : a journal and virtual library 2005;10():2478-88.
2004: Peter C Taylor; Richard O Williams; Eugene Eyo Akujuru
Tumour necrosis factor alpha as a therapeutic target for immune-mediated inflammatory diseases.
Current opinion in biotechnology 2004;15(6):557-63.
2004: Jamie Campbell; Cathleen J Ciesielski; Abigail E Hunt; Nicole J Horwood; Jonathan T Beech; Louise A Hayes; Agnes Denys; Eugene Eyo Akujuru; Fionula M Brennan; Brian M J Foxwell
A novel mechanism for TNF-alpha regulation by p38 MAPK: involvement of NF-kappa B with implications for therapy in rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):6928-37.
2004: Evangelos Andreakos; Brian M J Foxwell; Eugene Eyo Akujuru
Is targeting Toll-like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine-driven inflammation?
Immunological reviews 2004;202():250-65.
2004: Andrew P Cope; Eugene Eyo Akujuru
Emerging approaches for the therapy of autoimmune and chronic inflammatory disease.
Current opinion in immunology 2004;16(6):780-6.
2004: Magdalena Pertyńska-Marczewska; Serafim Kiriakidis; Robin Wait; Jonathan Beech; Eugene Eyo Akujuru; Ewa Paleolog
Advanced glycation end products upregulate angiogenic and pro-inflammatory cytokine production in human monocyte/macrophages.
Cytokine 2004;28(1):35-47.
2004: Claudia Monaco; Evangelos Andreakos; Serafim Kiriakidis; Claudia Mauri; Colin Bicknell; Brian M J Foxwell; N J W Cheshire; Ewa Paleolog; Eugene Eyo Akujuru
Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(15):5634-9.
2004: Percy F Sumariwalla; Anne-Marie Malfait; Eugene Eyo Akujuru
P-selectin glycoprotein ligand 1 therapy ameliorates established collagen-induced arthritis in DBA/1 mice partly through the suppression of tumour necrosis factor.
Clinical and experimental immunology 2004;136(1):67-75.
2004: Yuhua Zhang; Jun Xu; Jeremy Levin; Martin Hegen; Guangde Li; Heidi Robertshaw; Fionula Brennan; Terri Cummons; Dave Clarke; Nichole Vansell; Cheryl Nickerson-Nutter; Dauphine Barone; Ken Mohler; Roy Black; Jerauld S Skotnicki; Jay Gibbons; Eugene Eyo Akujuru; Philip Frost; Glenn Larsen; Lih-Ling Lin
Identification and characterization of 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a novel dual tumor necrosis factor-alpha-converting enzyme/matrix metalloprotease inhibitor for the treatment of rheumatoid arthritis.
The Journal of pharmacology and experimental therapeutics 2004;309(1):348-55.
2004: Evangelos Andreakos; Sandra M Sacre; Clive Smith; Anna M C Lundberg; Serafim Kiriakidis; Tim Stonehouse; Claudia Monaco; Eugene Eyo Akujuru; Brian M J Foxwell
Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.
Blood 2004;103(6):2229-37.
2004: Claudia Monaco; Evangelos Andreakos; Serafim Kiriakidis; Eugene Eyo Akujuru; Ewa Paleolog
T-cell-mediated signalling in immune, inflammatory and angiogenic processes: the cascade of events leading to inflammatory diseases.
Current drug targets. Inflammation and allergy 2004;3(1):35-42.
2004: Percy F Sumariwalla; Ruth Gallily; Susanna Tchilibon; Ester Fride; Urij Rampampam; Eugene Eyo Akujuru
A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis.
Arthritis and rheumatism 2004;50(3):985-98.
2004: Eugene Eyo Akujuru; Fionula M Brennan; Richard O Williams; Jim Woody; Ravinder N Maini
The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis.
Best practice & research. Clinical rheumatology 2004;18(1):59-80.
2004: Sandra M Sacre; Evangelos Andreakos; Eugene Eyo Akujuru; Brian M J Foxwell
Endotoxin signaling in human macrophages: signaling via an alternate mechanism.
Journal of endotoxin research 2004;10(6):445-52.
2004: Eugene Eyo Akujuru; Fionula M Brennan; Ewa Paleolog; Andrew P Cope; Peter Taylor; Richard Williams; Jim Woody; Ravinder N Maini
Anti-TNFalpha therapy of rheumatoid arthritis: what can we learn about chronic disease?
Novartis Foundation symposium 2004;256():53-69; discussion 69-73, 106-11, 266-9.
2003: Brian M J Foxwell; Evangelos Andreakos; Fionula Brennan; Eugene Eyo Akujuru; Clive Smith; Matthew Conron
Prospects for the development of small molecular weight compounds to replace anti-tumour necrosis factor biological agents.
Annals of the rheumatic diseases 2003;62 Suppl 2():ii90-3.
2003: A O Afuwape; Eugene Eyo Akujuru; Ewa Paleolog
Adenoviral delivery of soluble VEGF receptor 1 (sFlt-1) abrogates disease activity in murine collagen-induced arthritis.
Gene therapy 2003;10(23):1950-60.
2003: Eugene Eyo Akujuru; Ravinder N Maini
Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases.
Nature medicine 2003;9(10):1245-50.
2003: S Yoshimura; J Bondeson; Fionula M Brennan; Brian M J Foxwell; Eugene Eyo Akujuru
Antigen presentation by murine dendritic cells is nuclear factor-kappa B dependent both in vitro and in vivo.
Scandinavian journal of immunology 2003;58(2):165-72.
2003: Evangelos Andreakos; Clive Smith; Serafim Kiriakidis; Claudia Monaco; Rainer de Martin; Fionula M Brennan; Ewa Paleolog; Eugene Eyo Akujuru; Brian M J Foxwell
Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy.
Arthritis and rheumatism 2003;48(7):1901-12.
2003: V L Calder; J Bondeson; Fionula M Brennan; Brian M J Foxwell; Eugene Eyo Akujuru
Antigen-specific T-cell downregulation by human dendritic cells following blockade of NF-kappaB.
Scandinavian journal of immunology 2003;57(3):261-70.
2003: Serafim Kiriakidis; Evangelos Andreakos; Claudia Monaco; Brian M J Foxwell; Eugene Eyo Akujuru; Ewa Paleolog
VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2.
Journal of cell science 2003;116(Pt 4):665-74.
2003: Evangelos Andreakos; Clive Smith; Claudia Monaco; Fionula M Brennan; Brian M J Foxwell; Eugene Eyo Akujuru
Ikappa B kinase 2 but not NF-kappa B-inducing kinase is essential for effective DC antigen presentation in the allogeneic mixed lymphocyte reaction.
Blood 2003;101(3):983-91.
2003: Andrew D Foey; Sarah Field; Salman Ahmed; Abhilash Jain; Eugene Eyo Akujuru; Fionula M Brennan; Richard Williams
Impact of VIP and cAMP on the regulation of TNF-alpha and IL-10 production: implications for rheumatoid arthritis.
Arthritis research & therapy 2003;5(6):R317-28.
2003: Percy F Sumariwalla; Yihai Cao; Hua-Lin Wu; Eugene Eyo Akujuru; Ewa Paleolog
The angiogenesis inhibitor protease-activated kringles 1-5 reduces the severity of murine collagen-induced arthritis.
Arthritis research & therapy 2003;5(1):R32-9.
2002: Evangelos Andreakos; Peter C Taylor; Eugene Eyo Akujuru
Monoclonal antibodies in immune and inflammatory diseases.
Current opinion in biotechnology 2002;13(6):615-20.
2002: Eugene Eyo Akujuru; Evangelos Andreakos; Clive Smith; J Bondeson; S Yoshimura; Serafim Kiriakidis; Claudia Monaco; C Gasparini; Sandra M Sacre; Anna M C Lundberg; Ewa Paleolog; Nicole J Horwood; Fionula M Brennan; Brian M J Foxwell
Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?
Annals of the rheumatic diseases 2002;61 Suppl 2():ii13-8.
2002: Evangelos Andreakos; Brian M J Foxwell; Fionula M Brennan; Ravinder N Maini; Eugene Eyo Akujuru
Cytokines and anti-cytokine biologicals in autoimmunity: present and future.
Cytokine & growth factor reviews 2002;13(4-5):299-313.
2002: Cathleen J Ciesielski; Evangelos Andreakos; Brian M J Foxwell; Eugene Eyo Akujuru
TNFalpha-induced macrophage chemokine secretion is more dependent on NF-kappaB expression than lipopolysaccharides-induced macrophage chemokine secretion.
European journal of immunology 2002;32(7):2037-45.
2002: Eugene Eyo Akujuru
Development of anti-TNF therapy for rheumatoid arthritis.
Nature reviews. Immunology 2002;2(5):364-71.
2002: Claudia Monaco; Evangelos Andreakos; Sylvia Young; Eugene Eyo Akujuru; Ewa Paleolog
T cell-mediated signaling to vascular endothelium: induction of cytokines, chemokines, and tissue factor.
Journal of leukocyte biology 2002;71(4):659-68.
2002: Ravinder N Maini; Eugene Eyo Akujuru
How does infliximab work in rheumatoid arthritis?
Arthritis research 2002;4 Suppl 2():S22-8.
2002: Nicole J Horwood; Clive Smith; Evangelos Andreakos; Emilia Quattrocchi; Fionula M Brennan; Eugene Eyo Akujuru; Brian M J Foxwell
High-efficiency gene transfer into nontransformed cells: utility for studying gene regulation and analysis of potential therapeutic targets.
Arthritis research 2002;4 Suppl 3():S215-25.
2002: Andrew D Foey; Patricia Green; Brian M J Foxwell; Eugene Eyo Akujuru; Fionula Brennan
Cytokine-stimulated T cells induce macrophage IL-10 production dependent on phosphatidylinositol 3-kinase and p70S6K: implications for rheumatoid arthritis.
Arthritis research 2002;4(1):64-70.
2002: Eugene Eyo Akujuru; Ravinder N Maini
Discovery of TNF-alpha as a therapeutic target in rheumatoid arthritis: preclinical and clinical studies.
Joint, bone, spine : revue du rhumatisme 2002;69(1):12-8.
2002: Fionula M Brennan; Amanda L Hayes; Cathleen J Ciesielski; Patricia Green; Brian M J Foxwell; Eugene Eyo Akujuru
Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis.
Arthritis and rheumatism 2002;46(1):31-41.
2001: Andrew D Foey; Eugene Eyo Akujuru; Fionula M Brennan
CD40 ligation induces macrophage IL-10 and TNF-alpha production: differential use of the PI3K and p42/44 MAPK-pathways.
Cytokine 2001;16(4):131-42.
2001: Clive Smith; Evangelos Andreakos; JB Crawley; Fionula M Brennan; Eugene Eyo Akujuru; Brian M J Foxwell
NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5895-903.
2001: Brian M J Foxwell; S Yoshimura; J Bondeson; Fionula M Brennan; Eugene Eyo Akujuru
High efficiency gene transfer is an efficient way of defining therapeutic targets: a functional genomics approach.
Annals of the rheumatic diseases 2001;60 Suppl 3():iii13-7.
2001: SC Ballara; PC Taylor; Petra Reusch; Dieter Marmé; Eugene Eyo Akujuru; Ravinder N Maini; Ewa Paleolog
Raised serum vascular endothelial growth factor levels are associated with destructive change in inflammatory arthritis.
Arthritis and rheumatism 2001;44(9):2055-64.
2001: Matthew Conron; J Bondeson; P Pantelidis; H L C Beynon; Eugene Eyo Akujuru; R M duBois; Brian M J Foxwell
Alveolar macrophages and T cells from sarcoid, but not normal lung, are permissive to adenovirus infection and allow analysis of NF-kappa b-dependent signaling pathways.
American journal of respiratory cell and molecular biology 2001;25(2):141-9.
2001: S Yoshimura; J Bondeson; Fionula M Brennan; Brian M J Foxwell; Eugene Eyo Akujuru
Role of NFkappaB in antigen presentation and development of regulatory T cells elucidated by treatment of dendritic cells with the proteasome inhibitor PSI.
European journal of immunology 2001;31(6):1883-93.
2001: Emilia Quattrocchi; Margaret J Dallman; A P Dhillon; A Quaglia; Gian Filippo Bagnato; Eugene Eyo Akujuru
Murine IL-10 gene transfer inhibits established collagen-induced arthritis and reduces adenovirus-mediated inflammatory responses in mouse liver.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):5970-8.
2001: Eugene Eyo Akujuru; Fionula Brennan; J Bondeson; Ewa Paleolog; Brian M J Foxwell; R Maini
Analysis of cytokine expression in rheumatoid synovium has provided new insights into the pathogenesis of rheumatoid arthritis and new therapeutic opportunities.
Transplantation proceedings 2001;33(3):2085-6.
2001: Anne-Marie Malfait; Richard O Williams; AS Malik; Ravinder N Maini; Eugene Eyo Akujuru
Chronic relapsing homologous collagen-induced arthritis in DBA/1 mice as a model for testing disease-modifying and remission-inducing therapies.
Arthritis and rheumatism 2001;44(5):1215-24.
2001: S Yoshimura; J Bondeson; Brian M J Foxwell; Fionula M Brennan; Eugene Eyo Akujuru
Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines.
International immunology 2001;13(5):675-83.
2001: Cem Gabay; L Marinova-Mutafchieva; Richard O Williams; J P Gigley; DM Butler; Eugene Eyo Akujuru; William P Arend
Increased production of intracellular interleukin-1 receptor antagonist type I in the synovium of mice with collagen-induced arthritis: a possible role in the resolution of arthritis.
Arthritis and rheumatism 2001;44(2):451-62.
2001: Eugene Eyo Akujuru; Ravinder N Maini; J Bondeson; P Taylor; Brian M J Foxwell; Fionula M Brennan
Cytokine blockade in rheumatoid arthritis.
Advances in experimental medicine and biology 2001;490():119-27.
2001: Eugene Eyo Akujuru; Ravinder N Maini
Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?
Annual review of immunology 2001;19():163-96.
2000: Richard O Williams; L Marinova-Mutafchieva; Eugene Eyo Akujuru; Ravinder N Maini
Evaluation of TNF-alpha and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF-alpha/anti-CD4 therapy.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7240-5.
2000: P J Charles; RJ Smeenk; J De Jong; Eugene Eyo Akujuru; Ravinder N Maini
Assessment of antibodies to double-stranded DNA induced in rheumatoid arthritis patients following treatment with infliximab, a monoclonal antibody to tumor necrosis factor alpha: findings in open-label and randomized placebo-controlled trials.
Arthritis and rheumatism 2000;43(11):2383-90.
2000: Eugene Eyo Akujuru; JM Miotla; Ewa Paleolog; R Williams; Anne-Marie Malfait; P Taylor; Fionula M Brennan; Ravinder N Maini
Future prospects for anti-cytokine treatment.
Annals of the rheumatic diseases 2000;59 Suppl 1():i119-22.
2000: R O Williams; Eugene Eyo Akujuru; Ravinder N Maini
Cartilage destruction and bone erosion in arthritis: the role of tumour necrosis factor alpha.
Annals of the rheumatic diseases 2000;59 Suppl 1():i75-80.
2000: Brian M J Foxwell; J Bondeson; Fionula Brennan; Eugene Eyo Akujuru
Adenoviral transgene delivery provides an approach to identifying important molecular processes in inflammation: evidence for heterogenecity in the requirement for NFkappaB in tumour necrosis factor production.
Annals of the rheumatic diseases 2000;59 Suppl 1():i54-9.
2000: Andrew D Foey; Eugene Eyo Akujuru; Fionula M Brennan
Route of monocyte differentiation determines their cytokine production profile: CD40 ligation induces interleukin 10 expression.
Cytokine 2000;12(10):1496-505.
2000: J Bondeson; Fionula Brennan; Brian M J Foxwell; Eugene Eyo Akujuru
Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of matrix metalloproteinases and proinflammatory cytokines is nuclear factor-kappaB dependent.
The Journal of rheumatology 2000;27(9):2078-89.
2000: Anne-Marie Malfait; Ruth Gallily; Percy F Sumariwalla; AS Malik; Evangelos Andreakos; Urij Rampampam; Eugene Eyo Akujuru
The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(17):9561-6.
2000: JM Miotla; R Maciewicz; J Kendrew; Eugene Eyo Akujuru; Ewa Paleolog
Treatment with soluble VEGF receptor reduces disease severity in murine collagen-induced arthritis.
Laboratory investigation; a journal of technical methods and pathology 2000;80(8):1195-205.
2000: Emilia Quattrocchi; Margaret J Dallman; Eugene Eyo Akujuru
Adenovirus-mediated gene transfer of CTLA-4Ig fusion protein in the suppression of experimental autoimmune arthritis.
Arthritis and rheumatism 2000;43(8):1688-97.
2000: L Marinova-Mutafchieva; Richard O Williams; C Mauri; LJ Mason; MJ Walmsley; P C Taylor; Eugene Eyo Akujuru; Ravinder N Maini
A comparative study into the mechanisms of action of anti-tumor necrosis factor alpha, anti-CD4, and combined anti-tumor necrosis factor alpha/anti-CD4 treatment in early collagen-induced arthritis.
Arthritis and rheumatism 2000;43(3):638-44.
2000: P C Taylor; A M Peters; Ewa Paleolog; P T Chapman; M J Elliott; R McCloskey; Eugene Eyo Akujuru; Ravinder N Maini
Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis.
Arthritis and rheumatism 2000;43(1):38-47.
1999: Eugene Eyo Akujuru; Ravinder N Maini
The role of cytokines in the pathogenesis of rheumatoid arthritis.
Rheumatology (Oxford, England) 1999;38 Suppl 2():3-7.
1999: Richard O Williams; Anne-Marie Malfait; DM Butler; MJ Walmsley; Eugene Eyo Akujuru; Ravinder N Maini
Combination therapy with DMARDs and biological agents in collagen-induced arthritis.
Clinical and experimental rheumatology 1999;17(6 Suppl 18):S115-20.
1999: L M Webb; Brian M J Foxwell; Eugene Eyo Akujuru
Putative role for interleukin-7 in the maintenance of the recirculating naive CD4+ T-cell pool.
Immunology 1999;98(3):400-5.
1999: Ravinder N Maini; P C Taylor; Ewa Paleolog; P Charles; SC Ballara; Fionula M Brennan; Eugene Eyo Akujuru
Anti-tumour necrosis factor specific antibody (infliximab) treatment provides insights into the pathophysiology of rheumatoid arthritis.
Annals of the rheumatic diseases 1999;58 Suppl 1():I56-60.
1999: Eugene Eyo Akujuru; J Bondeson; Fionula M Brennan; Brian M J Foxwell; Ravinder N Maini
The rationale for the current boom in anti-TNFalpha treatment. Is there an effective means to define therapeutic targets for drugs that provide all the benefits of anti-TNFalpha and minimise hazards?
Annals of the rheumatic diseases 1999;58 Suppl 1():I27-31.
1999: P Charles; M J Elliott; D Davis; A Potter; J R Kalden; C Antoni; F C Breedveld; J S Smolen; G Eberl; K deWoody; Eugene Eyo Akujuru; Ravinder N Maini
Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(3):1521-8.
1999: E Quattrocchi; MJ Walmsley; K Browne; Richard O Williams; L Marinova-Mutafchieva; W Buurman; DM Butler; Eugene Eyo Akujuru
Paradoxical effects of adenovirus-mediated blockade of TNF activity in murine collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(2):1000-9.
1999: DM Butler; Anne-Marie Malfait; R N Maini; Fionula M Brennan; Eugene Eyo Akujuru
Anti-IL-12 and anti-TNF antibodies synergistically suppress the progression of murine collagen-induced arthritis.
European journal of immunology 1999;29(7):2205-12.
1999: Anne-Marie Malfait; AS Malik; L Marinova-Mutafchieva; DM Butler; Ravinder N Maini; Eugene Eyo Akujuru
The beta2-adrenergic agonist salbutamol is a potent suppressor of established collagen-induced arthritis: mechanisms of action.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):6278-83.
1999: J Bondeson; Brian M J Foxwell; Fionula Brennan; Eugene Eyo Akujuru
Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5668-73.
1999: J Bondeson; K A Browne; Fionula M Brennan; Brian M J Foxwell; Eugene Eyo Akujuru
Selective regulation of cytokine induction by adenoviral gene transfer of IkappaBalpha into human macrophages: lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-kappaB independent.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2939-45.
1998: Richard O Williams; C Mauri; LJ Mason; L Marinova-Mutafchieva; S E Ross; Eugene Eyo Akujuru; Ravinder N Maini
Therapeutic actions of cyclosporine and anti-tumor necrosis factor alpha in collagen-induced arthritis and the effect of combination therapy.
Arthritis and rheumatism 1998;41(10):1806-12.
1998: MJ Walmsley; DM Butler; L Marinova-Mutafchieva; Eugene Eyo Akujuru
An anti-inflammatory role for interleukin-11 in established murine collagen-induced arthritis.
Immunology 1998;95(1):31-7.
1998: Ravinder N Maini; F C Breedveld; Joachim R Kalden; J S Smolen; D Davis; J D Macfarlane; Christian Antoni; Burkhard F Leeb; MJ Elliott; Jim Woody; Thomas F Schaible; Eugene Eyo Akujuru
Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis.
Arthritis and rheumatism 1998;41(9):1552-63.
1998: J A Hermann; M A Hall; R N Maini; Eugene Eyo Akujuru; F M Brennan
Important immunoregulatory role of interleukin-11 in the inflammatory process in rheumatoid arthritis.
Arthritis and rheumatism 1998;41(8):1388-97.
1998: Brian M J Foxwell; K Browne; J Bondeson; chris clarke; R de Martin; Fionula Brennan; Eugene Eyo Akujuru
Efficient adenoviral infection with IkappaB alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappaB dependent.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(14):8211-5.
1998: Ewa Paleolog; S Young; A C Stark; R V McCloskey; Eugene Eyo Akujuru; Ravinder N Maini
Modulation of angiogenic vascular endothelial growth factor by tumor necrosis factor alpha and interleukin-1 in rheumatoid arthritis.
Arthritis and rheumatism 1998;41(7):1258-65.
1998: Maria-Jesus Sanz; L Marinova-Mutafchieva; P Green; Roy R Lobb; Eugene Eyo Akujuru; Sussan Nourshargh
IL-4-induced eosinophil accumulation in rat skin is dependent on endogenous TNF-alpha and alpha 4 integrin/VCAM-1 adhesion pathways.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(11):5637-45.
1998: Anne-Marie Malfait; DM Butler; D H Presky; Ravinder N Maini; Fionula M Brennan; Eugene Eyo Akujuru
Blockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritis.
Clinical and experimental immunology 1998;111(2):377-83.
1998: Andrew D Foey; SL Parry; Lynn M Williams; Eugene Eyo Akujuru; Brian M J Foxwell; Fionula M Brennan
Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: role of the p38 and p42/44 mitogen-activated protein kinases.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):920-8.
1998: Eugene Eyo Akujuru; F M Brennan; R Maini
Cytokines in autoimmune disorders.
International reviews of immunology 1998;17(1-4):217-28.
1998: Eugene Eyo Akujuru; P Charles; P Taylor; Ravinder N Maini
Biological insights from clinical trials with anti-TNF therapy.
Springer seminars in immunopathology 1998;20(1-2):211-28.
1998: F M Brennan; Ravinder N Maini; Eugene Eyo Akujuru
Role of pro-inflammatory cytokines in rheumatoid arthritis.
Springer seminars in immunopathology 1998;20(1-2):133-47.
1998: Eugene Eyo Akujuru; Ravinder N Maini
Rheumatoid arthritis: introduction.
Springer seminars in immunopathology 1998;20(1-2):3-4.
1997: S E Ross; Richard O Williams; LJ Mason; C Mauri; L Marinova-Mutafchieva; Anne-Marie Malfait; Ravinder N Maini; Eugene Eyo Akujuru
Suppression of TNF-alpha expression, inhibition of Th1 activity, and amelioration of collagen-induced arthritis by rolipram.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):6253-9.
1997: A C Horsfall; DM Butler; L Marinova; P J Warden; Richard O Williams; Ravinder N Maini; Eugene Eyo Akujuru
Suppression of collagen-induced arthritis by continuous administration of IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(11):5687-96.
1997: Maria-Jesus Sanz; Adele Hartnell; P Chisholm; C Williams; D Davies; V B Weg; Eugene Eyo Akujuru; M A Bolanowski; Roy R Lobb; Sussan Nourshargh
Tumor necrosis factor alpha-induced eosinophil accumulation in rat skin is dependent on alpha4 integrin/vascular cell adhesion molecule-1 adhesion pathways.
Blood 1997;90(10):4144-52.
1997: DM Butler; Anne-Marie Malfait; LJ Mason; P J Warden; george kollias; Ravinder N Maini; Eugene Eyo Akujuru; Fionula M Brennan
DBA/1 mice expressing the human TNF-alpha transgene develop a severe, erosive arthritis: characterization of the cytokine cascade and cellular composition.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):2867-76.
1997: D Davis; P J Charles; A Potter; Eugene Eyo Akujuru; Ravinder N Maini; M J Elliott
Anaemia of chronic disease in rheumatoid arthritis: in vivo effects of tumour necrosis factor alpha blockade.
British journal of rheumatology 1997;36(9):950-6.
1997: Shara Cohen; JB Crawley; M C Kahan; Eugene Eyo Akujuru; Brian M J Foxwell
Interleukin-10 rescues T cells from apoptotic cell death: association with an upregulation of Bcl-2.
Immunology 1997;92(1):1-5.
1997: Eugene Eyo Akujuru; Fionula Brennan; Ewa Paleolog; P Taylor; R N Maini
Anti-tumor necrosis factor alpha therapy of rheumatoid arthritis. Mechanism of action.
European cytokine network 1997;8(3):297-300.
1997: C Fiehn; E M Paleolog; Eugene Eyo Akujuru
Selective enhancement of endothelial cell VCAM-1 expression by interleukin-10 in the presence of activated leucocytes.
Immunology 1997;91(4):565-71.
1997: Fionula M Brennan; K A Browne; P A Green; J M Jaspar; Ravinder N Maini; Eugene Eyo Akujuru
Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti-tumour necrosis factor-alpha (cA2) therapy.
British journal of rheumatology 1997;36(6):643-50.
1997: SL Parry; M Sebbag; Eugene Eyo Akujuru; Fionula M Brennan
Contact with T cells modulates monocyte IL-10 production: role of T cell membrane TNF-alpha.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(8):3673-81.
1997: Ravinder N Maini; M Elliott; Fionula M Brennan; Richard O Williams; Eugene Eyo Akujuru
TNF blockade in rheumatoid arthritis: implications for therapy and pathogenesis.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1997;105(4):257-63.
1997: L M Webb; B M Foxwell; Eugene Eyo Akujuru
Interleukin-7 activates human naive CD4+ cells and primes for interleukin-4 production.
European journal of immunology 1997;27(3):633-40.
1997: M Sebbag; SL Parry; Fionula M Brennan; Eugene Eyo Akujuru
Cytokine stimulation of T lymphocytes regulates their capacity to induce monocyte production of tumor necrosis factor-alpha, but not interleukin-10: possible relevance to pathophysiology of rheumatoid arthritis.
European journal of immunology 1997;27(3):624-32.
1997: L Marinova-Mutafchieva; Richard O Williams; LJ Mason; C Mauri; Eugene Eyo Akujuru; Ravinder N Maini
Dynamics of proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis (CIA).
Clinical and experimental immunology 1997;107(3):507-12.
1997: Eugene Eyo Akujuru; MJ Elliott; Jim Woody; Ravinder N Maini
Anti-tumor necrosis factor-alpha therapy of rheumatoid arthritis.
Advances in immunology 1997;64():283-350.
1996: L M Webb; MJ Walmsley; Eugene Eyo Akujuru
Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: requirement for both B7-1 and B7-2.
European journal of immunology 1996;26(10):2320-8.
1996: C Mauri; Richard O Williams; MJ Walmsley; Eugene Eyo Akujuru
Relationship between Th1/Th2 cytokine patterns and the arthritogenic response in collagen-induced arthritis.
European journal of immunology 1996;26(7):1511-8.
1996: Ewa Paleolog; M Hunt; M J Elliott; Eugene Eyo Akujuru; Ravinder N Maini; J N Woody
Deactivation of vascular endothelium by monoclonal anti-tumor necrosis factor alpha antibody in rheumatoid arthritis.
Arthritis and rheumatism 1996;39(7):1082-91.
1996: L M Williams; D L Gibbons; A Gearing; Ravinder N Maini; Eugene Eyo Akujuru; Fionula M Brennan
Paradoxical effects of a synthetic metalloproteinase inhibitor that blocks both p55 and p75 TNF receptor shedding and TNF alpha processing in RA synovial membrane cell cultures.
The Journal of clinical investigation 1996;97(12):2833-41.
1996: R Neve; M Kissonerghis; J Clark; Eugene Eyo Akujuru; Yuti Chernajovsky
Expression of an efficient small molecular weight tumour necrosis factor/lymphotoxin antagonist.
Cytokine 1996;8(5):365-70.
1996: Shara Cohen; L M Webb; Eugene Eyo Akujuru
The method of deriving human T-cell clones alters the proportion of IL-10-producing cells.
Immunology 1996;87(3):343-7.
1996: MJ Walmsley; P D Katsikis; E Abney; S Parry; Richard O Williams; Ravinder N Maini; Eugene Eyo Akujuru
Interleukin-10 inhibition of the progression of established collagen-induced arthritis.
Arthritis and rheumatism 1996;39(3):495-503.
1996: K E Norman; Timothy J Williams; Eugene Eyo Akujuru; A G Rossi
Effect of soluble P55 tumour-necrosis factor binding fusion protein on the local Shwartzman and Arthus reactions.
British journal of pharmacology 1996;117(3):471-478.
1996: Sonia Quaratino; Eugene Eyo Akujuru; C M Dayan; Oreste Acuto; Marco Londei
Human self-reactive T cell clones expressing identical T cell receptor beta chains differ in their ability to recognize a cryptic self-epitope.
The Journal of experimental medicine 1996;183(2):349-58.
1996: SM Brookes; Shara Cohen; E J Price; L M Webb; Eugene Eyo Akujuru; Ravinder N Maini; Patrick J W Venables
T cell clones from a Sjögren's syndrome salivary gland biopsy produce high levels of IL-10.
Clinical and experimental immunology 1996;103(2):268-72.
1995: B J Scallon; H Trinh; M Nedelman; Fionula M Brennan; Eugene Eyo Akujuru; J Ghrayeb
Functional comparisons of different tumour necrosis factor receptor/IgG fusion proteins.
Cytokine 1995;7(8):759-70.
1995: L M Webb; Eugene Eyo Akujuru
Critical role of CD28/B7 costimulation in the development of human Th2 cytokine-producing cells.
Blood 1995;86(9):3479-86.
1995: chris clarke; David Taylor-Fishwick; A Hales; Yuti Chernajovsky; K Sugamura; Eugene Eyo Akujuru; Brian M J Foxwell
Interleukin-4 inhibits kappa light chain expression and NF kappa B activation but not I kappa B alpha degradation in 70Z/3 murine pre-B cells.
European journal of immunology 1995;25(10):2961-6.
1995: Eugene Eyo Akujuru; F M Brennan; M J Elliott; R O Williams; Ravinder N Maini
TNF alpha is an effective therapeutic target for rheumatoid arthritis.
Annals of the New York Academy of Sciences 1995;766():272-8.
1995: Ravinder N Maini; M J Elliott; Fionula M Brennan; Eugene Eyo Akujuru
Beneficial effects of tumour necrosis factor-alpha (TNF-alpha) blockade in rheumatoid arthritis (RA)
Clinical and experimental immunology 1995;101(2):207-12.
1995: P D Katsikis; Shara Cohen; Marco Londei; Eugene Eyo Akujuru
Are CD4+ Th1 cells pro-inflammatory or anti-inflammatory? The ratio of IL-10 to IFN-gamma or IL-2 determines their function.
International immunology 1995;7(8):1287-94.
1995: Marco Londei; C Dayan; Eugene Eyo Akujuru; Oreste Acuto; Sonia Quaratino
Human autoreactive T-cell clones show flexibility in recognizing overlapping microepitopes, but inflexibility in T-cell receptor usage.
Annals of the New York Academy of Sciences 1995;756():345-8.
1995: DM Butler; Ravinder N Maini; Eugene Eyo Akujuru; Fionula M Brennan
Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures. Comparison of monoclonal anti TNF-alpha antibody with the interleukin-1 receptor antagonist.
European cytokine network 1995;6(4):225-30.
1995: N R Chu; Sonia Quaratino; Eugene Eyo Akujuru; Marco Londei
Comparison of peptide and superantigen-induced anergy in a peptide-specific polyclonal human T cell line.
International immunology 1995;7(7):1057-63.
1995: Fionula M Brennan; D L Gibbons; A P Cope; P Katsikis; Ravinder N Maini; Eugene Eyo Akujuru
TNF inhibitors are produced spontaneously by rheumatoid and osteoarthritic synovial joint cell cultures: evidence of feedback control of TNF action.
Scandinavian journal of immunology 1995;42(1):158-65.
1995: R J Mullins; Shara Cohen; L M Webb; Y Chernajovsky; C M Dayan; Marco Londei; Eugene Eyo Akujuru
Identification of thyroid stimulating hormone receptor-specific T cells in Graves' disease thyroid using autoantigen-transfected Epstein-Barr virus-transformed B cell lines.
The Journal of clinical investigation 1995;96(1):30-7.
1995: Shara Cohen; P D Katsikis; Cong-Qiu Chu; H Thomssen; L M Webb; Ravinder N Maini; Marco Londei; Eugene Eyo Akujuru
High level of interleukin-10 production by the activated T cell population within the rheumatoid synovial membrane.
Arthritis and rheumatism 1995;38(7):946-52.
1995: P D Katsikis; Shara Cohen; J G Murison; J Uren; L M Hibbart; R E Callard; F Di Padova; Eugene Eyo Akujuru; Marco Londei
Human alpha beta T-cell receptor CD4-CD8 T-cell clones are predominantly Th0-like.
Immunology 1995;84(4):501-4.
1995: Ravinder N Maini; M J Elliott; Fionula M Brennan; R O Williams; Cong-Qiu Chu; Ewa Paleolog; P J Charles; P C Taylor; Eugene Eyo Akujuru
Monoclonal anti-TNF alpha antibody as a probe of pathogenesis and therapy of rheumatoid disease.
Immunological reviews 1995;144():195-223.
1995: Richard O Williams; J Ghrayeb; Eugene Eyo Akujuru; Ravinder N Maini
Successful therapy of collagen-induced arthritis with TNF receptor-IgG fusion protein and combination with anti-CD4.
Immunology 1995;84(3):433-9.
1995: V B Weg; D T Walsh; L H Faccioli; Timothy J Williams; Eugene Eyo Akujuru; Sussan Nourshargh
LPS-induced 111In-eosinophil accumulation in guinea-pig skin: evidence for a role for TNF-alpha.
Immunology 1995;84(1):36-40.
1995: A P Cope; D Aderka; David Wallach; M Kahan; N R Chu; Fionula M Brennan; Eugene Eyo Akujuru
Soluble TNF receptor production by activated T lymphocytes: differential effects of acute and chronic exposure to TNF.
Immunology 1995;84(1):21-30.
1995: Fionula M Brennan; A P Cope; P Katsikis; D L Gibbons; Ravinder N Maini; Eugene Eyo Akujuru
Selective immunosuppression of tumour necrosis factor-alpha in rheumatoid arthritis.
Chemical immunology 1995;60():48-60.
1994: DM Butler; B Scallon; A Meager; M Kissonerghis; A Corcoran; Yuti Chernajovsky; Eugene Eyo Akujuru; J Ghrayeb; Fionula M Brennan
TNF receptor fusion proteins are effective inhibitors of TNF-mediated cytotoxicity on human KYM-1D4 rhabdomyosarcoma cells.
Cytokine 1994;6(6):616-23.
1994: Shara Cohen; P D Katsikis; Eugene Eyo Akujuru; Marco Londei
IL-10 enhances expression of the IL-2 receptor alpha chain on T cells.
Immunology 1994;83(3):329-32.
1994: Ravinder N Maini; M Elliott; Fionula M Brennan; R O Williams; Eugene Eyo Akujuru
Targeting TNF alpha for the therapy of rheumatoid arthritis.
Clinical and experimental rheumatology 1994;12 Suppl 11():S63-6.
1994: M J Elliott; Ravinder N Maini; Eugene Eyo Akujuru; A Long-Fox; P Charles; H Bijl; J N Woody
Repeated therapy with monoclonal antibody to tumour necrosis factor alpha (cA2) in patients with rheumatoid arthritis.
Lancet 1994;344(8930):1125-7.
1994: M J Elliott; Ravinder N Maini; Eugene Eyo Akujuru; J R Kalden; C Antoni; J S Smolen; Burkhard F Leeb; F C Breedveld; J D Macfarlane; H Bijl
Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis.
Lancet 1994;344(8930):1105-10.
1994: Ewa Paleolog; S A Delasalle; W A Buurman; Eugene Eyo Akujuru
Functional activities of receptors for tumor necrosis factor-alpha on human vascular endothelial cells.
Blood 1994;84(8):2578-90.
1994: DM Butler; Eugene Eyo Akujuru; F Di Padova; Fionula M Brennan
p55 and p75 tumor necrosis factor receptors are expressed and mediate common functions in synovial fibroblasts and other fibroblasts.
European cytokine network 1994;5(5):441-8.
1994: D L Gibbons; M Rowe; A P Cope; Eugene Eyo Akujuru; Fionula M Brennan
Lymphotoxin acts as an autocrine growth factor for Epstein-Barr virus-transformed B cells and differentiated Burkitt lymphoma cell lines.
European journal of immunology 1994;24(8):1879-85.
1994: A E Corcoran; K Barrett; M Turner; A Brown; A M Kissonerghis; M Gadnell; Patrick W Gray; Yuti Chernajovsky; Eugene Eyo Akujuru
Characterization of ligand binding by the human p55 tumour-necrosis-factor receptor. Involvement of individual cysteine-rich repeats.
European journal of biochemistry / FEBS 1994;223(3):831-40.
1994: A P Cope; Marco Londei; N R Chu; Shara Cohen; M J Elliott; Fionula M Brennan; Ravinder N Maini; Eugene Eyo Akujuru
Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis.
The Journal of clinical investigation 1994;94(2):749-60.
1994: R J Mullins; Y Chernajovsky; C Dayan; Marco Londei; Eugene Eyo Akujuru
Transfection of thyroid autoantigens into EBV-transformed B cell lines. Recognition by Graves' disease thyroid T cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(11):5572-80.
1994: P D Katsikis; Cong-Qiu Chu; Fionula M Brennan; Ravinder N Maini; Eugene Eyo Akujuru
Immunoregulatory role of interleukin 10 in rheumatoid arthritis.
The Journal of experimental medicine 1994;179(5):1517-27.
1994: R O Williams; L J Mason; Eugene Eyo Akujuru; Ravinder N Maini
Synergy between anti-CD4 and anti-tumor necrosis factor in the amelioration of established collagen-induced arthritis.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(7):2762-6.
1994: Ravinder N Maini; M J Elliott; P J Charles; Eugene Eyo Akujuru
Immunological intervention reveals reciprocal roles for tumor necrosis factor-alpha and interleukin-10 in rheumatoid arthritis and systemic lupus erythematosus.
Springer seminars in immunopathology 1994;16(2-3):327-36.
1993: M J Elliott; Ravinder N Maini; Eugene Eyo Akujuru; A Long-Fox; P Charles; P Katsikis; Fionula M Brennan; J Walker; H Bijl; J Ghrayeb
Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha.
Arthritis and rheumatism 1993;36(12):1681-90.
1993: M Kristensen; Cong-Qiu Chu; D J Eedy; Eugene Eyo Akujuru; Fionula M Brennan; S M Breathnach
Localization of tumour necrosis factor-alpha (TNF-alpha) and its receptors in normal and psoriatic skin: epidermal cells express the 55-kD but not the 75-kD TNF receptor.
Clinical and experimental immunology 1993;94(2):354-62.
1993: Ewa Paleolog; P Katsikis; G Harris; P Daddona; M R Dalesandro; C S Kinney; J N Woody; Eugene Eyo Akujuru
Antilipid A monoclonal antibody HA-1A decreases the capacity of bacterial lipopolysaccharide to activate human vascular endothelial cells by an immune adherence mechanism.
Cytokine 1993;5(6):570-7.
1993: D Aderka; A Wysenbeek; Hartmut Engelmann; A P Cope; F Brennan; Y Molad; V Hornik; Y Levo; Ravinder N Maini; Eugene Eyo Akujuru
Correlation between serum levels of soluble tumor necrosis factor receptor and disease activity in systemic lupus erythematosus.
Arthritis and rheumatism 1993;36(8):1111-20.
1993: C M Dayan; N R Chu; Marco Londei; B Rapoport; Eugene Eyo Akujuru
T cells involved in human autoimmune disease are resistant to tolerance induction.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(3):1606-13.
1993: C Haworth; S M O'Reilly; E Chu; G J Rustin; Eugene Eyo Akujuru
Flavone acetic acid (FAA) with recombinant interleukin-2 (rIL-2) in advanced malignant melanoma. III: Cytokine studies.
British journal of cancer 1993;67(6):1346-50.
1993: A P Cope; D L Gibbons; D Aderka; Brian M J Foxwell; David Wallach; Ravinder N Maini; Eugene Eyo Akujuru; Fionula M Brennan
Differential regulation of tumour necrosis factor receptors (TNF-R) by IL-4; upregulation of P55 and P75 TNF-R on synovial joint mononuclear cells.
Cytokine 1993;5(3):205-12.
1993: Ravinder N Maini; Fionula M Brennan; R Williams; Cong-Qiu Chu; A P Cope; D Gibbons; M Elliott; Eugene Eyo Akujuru
TNF-alpha in rheumatoid arthritis and prospects of anti-TNF therapy.
Clinical and experimental rheumatology 1993;11 Suppl 8():S173-5.
1992: Bent Deleuran; Cong-Qiu Chu; M Field; Fionula M Brennan; P Katsikis; Eugene Eyo Akujuru; Ravinder N Maini
Localization of interleukin-1 alpha, type 1 interleukin-1 receptor and interleukin-1 receptor antagonist in the synovial membrane and cartilage/pannus junction in rheumatoid arthritis.
British journal of rheumatology 1992;31(12):801-9.
1992: Brian M J Foxwell; K Barrett; Eugene Eyo Akujuru
Cytokine receptors: structure and signal transduction.
Clinical and experimental immunology 1992;90(2):161-9.
1992: Ewa Paleolog; G R Aluri; Eugene Eyo Akujuru
Contrasting effects of interferon gamma and interleukin 4 on responses of human vascular endothelial cells to tumour necrosis factor alpha.
Cytokine 1992;4(6):470-8.
1992: R O Williams; Eugene Eyo Akujuru; R N Maini
Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9784-8.
1992: Cong-Qiu Chu; M Field; S Allard; E Abney; Eugene Eyo Akujuru; Ravinder N Maini
Detection of cytokines at the cartilage/pannus junction in patients with rheumatoid arthritis: implications for the role of cytokines in cartilage destruction and repair.
British journal of rheumatology 1992;31(10):653-61.
1992: Bent Deleuran; Cong-Qiu Chu; M Field; Fionula M Brennan; T Mitchell; Eugene Eyo Akujuru; Ravinder N Maini
Localization of tumor necrosis factor receptors in the synovial tissue and cartilage-pannus junction in patients with rheumatoid arthritis. Implications for local actions of tumor necrosis factor alpha.
Arthritis and rheumatism 1992;35(10):1170-8.
1992: A P Cope; D Aderka; M Doherty; Hartmut Engelmann; D Gibbons; A C Jones; Fionula M Brennan; Ravinder N Maini; David Wallach; Eugene Eyo Akujuru
Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases.
Arthritis and rheumatism 1992;35(10):1160-9.
1992: R Sadeghi; C M Hawrylowicz; Y Chernajovsky; Eugene Eyo Akujuru
Synergism of glucocorticoids with granulocyte macrophage colony stimulating factor (GM-CSF) but not interferon gamma (IFN-gamma) or interleukin-4 (IL-4) on induction of HLA class II expression on human monocytes.
Cytokine 1992;4(4):287-97.
1992: R Sadeghi; Eugene Eyo Akujuru; C Hawrylowicz
Upregulation of HLA class II, but not intercellular adhesion molecule 1 (ICAM-1) by granulocyte-macrophage colony stimulating factor (GM-CSF) or interleukin-3 (IL-3) in synergy with dexamethasone.
European cytokine network 1992;3(4):373-80.
1992: Fionula M Brennan; D L Gibbons; T Mitchell; A P Cope; Ravinder N Maini; Eugene Eyo Akujuru
Enhanced expression of tumor necrosis factor receptor mRNA and protein in mononuclear cells isolated from rheumatoid arthritis synovial joints.
European journal of immunology 1992;22(7):1907-12.
1992: Fionula M Brennan; Ravinder N Maini; Eugene Eyo Akujuru
TNF alpha--a pivotal role in rheumatoid arthritis?
British journal of rheumatology 1992;31(5):293-8.
1992: Eugene Eyo Akujuru; C Dayan; B Rapoport; Marco Londei
T cell activation and antigen presentation in human thyroid autoimmunity.
Journal of autoimmunity 1992;5 Suppl A():115-21.
1992: R Q Zheng; E R Abney; Cong-Qiu Chu; M Field; Ravinder N Maini; J R Lamb; Eugene Eyo Akujuru
Detection of in vivo production of tumour necrosis factor-alpha by human thyroid epithelial cells.
Immunology 1992;75(3):456-62.
1992: Eugene Eyo Akujuru; C Dayan; Beatrix Grubeck-Loebenstein; B Rapoport; Marco Londei
Mechanism of Graves thyroiditis: implications for concepts and therapy of autoimmunity.
International reviews of immunology 1992;9(2):91-106.
1992: C M Dayan; Eugene Eyo Akujuru; B Rapoport; Marco Londei
Autoimmune thyroiditis and targeted anti-T cell immunotherapy in man.
Autoimmunity 1992;11(3):189-98.
1992: Eugene Eyo Akujuru; Fionula M Brennan; Richard O Williams; A P Cope; D L Gibbons; P D Katsikis; Ravinder N Maini
Evaluation of the role of cytokines in autoimmune disease: the importance of TNF alpha in rheumatoid arthritis.
Progress in growth factor research 1992;4(3):247-55.
1991: David Naor; G Essery; N Tarcic; M Kahan; Eugene Eyo Akujuru
Regulatory interactions among autologous T cell clones. Human bifunctional T cell clones regulate the activity of an autologous T cell clone.
Annals of the New York Academy of Sciences 1991;636():135-46.
1991: Cong-Qiu Chu; M Field; E Abney; R Q Zheng; S Allard; Eugene Eyo Akujuru; Ravinder N Maini
Transforming growth factor-beta 1 in rheumatoid synovial membrane and cartilage/pannus junction.
Clinical and experimental immunology 1991;86(3):380-6.
1991: C Haworth; Fionula M Brennan; David Chantry; M Turner; Ravinder N Maini; Eugene Eyo Akujuru
Expression of granulocyte-macrophage colony-stimulating factor in rheumatoid arthritis: regulation by tumor necrosis factor-alpha.
European journal of immunology 1991;21(10):2575-9.
1991: C M Hawrylowicz; G L Howells; Eugene Eyo Akujuru
Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production.
The Journal of experimental medicine 1991;174(4):785-90.
1991: C M Dayan; Marco Londei; A E Corcoran; Beatrix Grubeck-Loebenstein; R F James; B Rapoport; Eugene Eyo Akujuru
Autoantigen recognition by thyroid-infiltrating T cells in Graves disease.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(16):7415-9.
1991: M Turner; David Chantry; P Katsikis; A Berger; Fionula M Brennan; Eugene Eyo Akujuru
Induction of the interleukin 1 receptor antagonist protein by transforming growth factor-beta.
European journal of immunology 1991;21(7):1635-9.
1991: K Barrett; David Taylor-Fishwick; A P Cope; A M Kissonerghis; P W Gray; Eugene Eyo Akujuru; Brian M J Foxwell
Cloning, expression and cross-linking analysis of the murine p55 tumor necrosis factor receptor.
European journal of immunology 1991;21(7):1649-56.
1991: S Kontiainen; R Toomath; J Lowder; Eugene Eyo Akujuru
Selective activation of T cells in newly diagnosed insulin-dependent diabetic patients: evidence for heterogeneity of T cell receptor usage.
Clinical and experimental immunology 1991;83(3):347-51.
1991: Eugene Eyo Akujuru; Fionula M Brennan; David Chantry; C Haworth; M Turner; P Katsikis; Marco Londei; E Abney; G Buchan; K Barrett
Cytokine assays: role in evaluation of the pathogenesis of autoimmunity.
Immunological reviews 1991;119():105-23.
1991: R Q Zheng; E Abney; Cong-Qiu Chu; M Field; Beatrix Grubeck-Loebenstein; Ravinder N Maini; Eugene Eyo Akujuru
Detection of interleukin-6 and interleukin-1 production in human thyroid epithelial cells by non-radioactive in situ hybridization and immunohistochemical methods.
Clinical and experimental immunology 1991;83(2):314-9.
1991: Fionula M Brennan; M Field; Cong-Qiu Chu; Eugene Eyo Akujuru; Ravinder N Maini
Cytokine expression in rheumatoid arthritis.
British journal of rheumatology 1991;30 Suppl 1():76-80.
1991: G Howells; P Pham; David Taylor-Fishwick; B Foxwell; Eugene Eyo Akujuru
Interleukin 4 induces interleukin 6 production by endothelial cells: synergy with interferon-gamma.
European journal of immunology 1991;21(1):97-101.
1991: Eugene Eyo Akujuru
Cytokine networks: do we understand them well enough to facilitate clinical benefits?
European cytokine network 1991;2(1):5-9.
1990: R Q Zheng; E R Abney; Beatrix Grubeck-Loebenstein; C Dayan; Ravinder N Maini; Eugene Eyo Akujuru
Expression of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-3 on human thyroid epithelial cells in Graves' and Hashimoto's diseases.
Journal of autoimmunity 1990;3(6):727-36.
1990: Beatrix Grubeck-Loebenstein; M Turner; K Pirich; H Kassal; Marco Londei; W Waldhäusl; Eugene Eyo Akujuru
CD4+ T-cell clones from autoimmune thyroid tissue cannot be classified according to their lymphokine production.
Scandinavian journal of immunology 1990;32(5):433-40.
1990: Patrick W Gray; K Barrett; David Chantry; M Turner; Eugene Eyo Akujuru
Cloning of human tumor necrosis factor (TNF) receptor cDNA and expression of recombinant soluble TNF-binding protein.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(19):7380-4.
1990: Fionula M Brennan; C O Zachariae; David Chantry; C G Larsen; M Turner; Ravinder N Maini; K Matsushima; Eugene Eyo Akujuru
Detection of interleukin 8 biological activity in synovial fluids from patients with rheumatoid arthritis and production of interleukin 8 mRNA by isolated synovial cells.
European journal of immunology 1990;20(9):2141-4.
1990: David Naor; G Essery; N Tarcic; M Kahan; J R Lamb; Eugene Eyo Akujuru
Specific interactions between a human CD4+ clone and autologous CD4+ bifunctional immunoregulatory clones.
Immunological reviews 1990;116():63-83.
1990: David Naor; G Essery; N Tarcic; M Kahan; Eugene Eyo Akujuru
Interactions between autologous T cell clones.
Cellular immunology 1990;128(2):490-502.
1990: Ravinder N Maini; C Plater-Zyberk; C M Brown; S Aghamohammadi; Fionula M Brennan; Eugene Eyo Akujuru
CD5+B cells in rheumatoid arthritis and Sjögren's syndrome.
Clinical and experimental rheumatology 1990;8 Suppl 5():67-8.
1990: Eugene Eyo Akujuru; Fionula M Brennan; David Chantry; C Haworth; M Turner; E Abney; G Buchan; K Barrett; D Barkley; A Chu
Cytokine production in the rheumatoid joint: implications for treatment.
Annals of the rheumatic diseases 1990;49 Suppl 1():480-6.
1990: M Turner; David Chantry; Eugene Eyo Akujuru
Transforming growth factor beta induces the production of interleukin 6 by human peripheral blood mononuclear cells.
Cytokine 1990;2(3):211-6.
1990: Marco Londei; A Verhoef; C Hawrylowicz; J Groves; P De Berardinis; Eugene Eyo Akujuru
Interleukin 7 is a growth factor for mature human T cells.
European journal of immunology 1990;20(2):425-8.
1990: David Chantry; M Turner; F Brennan; A Kingsbury; Eugene Eyo Akujuru
Granulocyte-macrophage colony stimulating factor induces both HLA-DR expression and cytokine production by human monocytes.
Cytokine 1990;2(1):60-7.
1990: I Todd; L J Hammond; R F James; Eugene Eyo Akujuru; G F Bottazzo
Epidermal growth factor and transforming growth factor-alpha suppress HLA class II induction in human thyroid epithelial cells.
Immunology 1990;69(1):91-6.
1990: C Varma; David Chantry; F Brennan; M Turner; F Katz; Eugene Eyo Akujuru
Interleukin 7 and interleukin 4 stimulate human thymocyte growth through distinct mechanisms.
Cytokine 1990;2(1):55-9.
1989: M Turner; David Chantry; G Buchan; K Barrett; Eugene Eyo Akujuru
Regulation of expression of human IL-1 alpha and IL-1 beta genes.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(11):3556-61.
1989: Marco Londei; A Verhoef; P De Berardinis; M Kissonerghis; Beatrix Grubeck-Loebenstein; Eugene Eyo Akujuru
Definition of a population of CD4-8- T cells that express the alpha beta T-cell receptor and respond to interleukins 2, 3, and 4.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(21):8502-6.
1989: M Partridge; M R Green; J D Langdon; Eugene Eyo Akujuru
Production of TGF-alpha and TGF-beta by cultured keratinocytes, skin and oral squamous cell carcinomas--potential autocrine regulation of normal and malignant epithelial cell proliferation.
British journal of cancer 1989;60(4):542-8.
1989: Beatrix Grubeck-Loebenstein; G Buchan; David Chantry; H Kassal; Marco Londei; K Pirich; K Barrett; M Turner; W Waldhausl; Eugene Eyo Akujuru
Analysis of intrathyroidal cytokine production in thyroid autoimmune disease: thyroid follicular cells produce interleukin-1 alpha and interleukin-6.
Clinical and experimental immunology 1989;77(3):324-30.
1989: F Brennan; C Plater-Zyberk; Ravinder N Maini; Eugene Eyo Akujuru
Coordinate expansion of 'fetal type' lymphocytes (TCR gamma delta+T and CD5+B) in rheumatoid arthritis and primary Sjögren's syndrome.
Clinical and experimental immunology 1989;77(2):175-8.
1989: Fionula M Brennan; David Chantry; andrew jackson; Ravinder N Maini; Eugene Eyo Akujuru
Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis.
Lancet 1989;2(8657):244-7.
1989: C R Hewitt; Eugene Eyo Akujuru
Human T cell clones present antigen.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(2):762-9.
1989: David Chantry; M Turner; E Abney; Eugene Eyo Akujuru
Modulation of cytokine production by transforming growth factor-beta.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(12):4295-300.
1989: Beatrix Grubeck-Loebenstein; G Buchan; David Chantry; M Turner; Marco Londei; Eugene Eyo Akujuru
Intrathyroidal cytokine production in thyroid disease.
Journal of autoimmunity 1989;2 Suppl():171-6.
1989: David Naor; G Essery; M Kahan; Eugene Eyo Akujuru
T-cell clone anti-clone interactions. Effects on suppressor and helper activities.
Journal of autoimmunity 1989;2 Suppl():3-14.
1989: Fionula M Brennan; David Chantry; andrew jackson; Ravinder N Maini; Eugene Eyo Akujuru
Cytokine production in culture by cells isolated from the synovial membrane.
Journal of autoimmunity 1989;2 Suppl():177-86.
1989: C Plater-Zyberk; Fionula M Brennan; Eugene Eyo Akujuru; Ravinder N Maini
'Fetal-type' B and T lymphocytes in rheumatoid arthritis and primary Sjögren's syndrome.
Journal of autoimmunity 1989;2 Suppl():233-41.
1989: David Chantry; M Turner; Eugene Eyo Akujuru
Interleukin 7 (murine pre-B cell growth factor/lymphopoietin 1) stimulates thymocyte growth: regulation by transforming growth factor beta.
European journal of immunology 1989;19(4):783-6.
1989: P De Berardinis; Marco Londei; R F James; S P Lake; Peter Wise; Eugene Eyo Akujuru
CD4+ T-cell damage to islet beta cells.
Lancet 1989;1(8633):329.
1989: G Portillo; M Turner; David Chantry; Eugene Eyo Akujuru
Effect of cytokines on HLA-DR and IL-1 production by a monocytic tumour, THP-1.
Immunology 1989;66(2):170-5.
1989: A M Kissonerghis; Ravinder N Maini; Eugene Eyo Akujuru
High rate of HLA class II mRNA synthesis in rheumatoid arthritis joints and its persistence in culture: down-regulation by recombinant interleukin 2.
Scandinavian journal of immunology 1989;29(1):73-82.
1989: Eugene Eyo Akujuru
Molecular mechanisms involved in human autoimmune diseases: relevance of chronic antigen presentation. Class II expression and cytokine production.
Immunology. Supplement 1989;2():66-71; discussion 72-3.
1989: A M Kissonerghis; Beatrix Grubeck-Loebenstein; K Pirich; Eugene Eyo Akujuru; Marco Londei
Tumour necrosis factor synergises with gamma interferon on the induction of mRNA for DR alpha chain on thyrocytes from Graves' disease and non toxic goitre.
Autoimmunity 1989;4(4):255-66.
1989: David Chantry; C G Winearls; Ravinder N Maini; Eugene Eyo Akujuru
Mechanism of immune complex-mediated damage: induction of interleukin 1 by immune complexes and synergy with interferon-gamma and tumor necrosis factor-alpha.
European journal of immunology 1989;19(1):189-92.
1989: Marco Londei; C M Savill; A Verhoef; F Brennan; Z A Leech; V Duance; Ravinder N Maini; Eugene Eyo Akujuru
Persistence of collagen type II-specific T-cell clones in the synovial membrane of a patient with rheumatoid arthritis.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(2):636-40.
1988: Toshio Hirano; Toshio Matsuda; M Turner; N Miyasaka; G Buchan; B Tang; K Sato; Masahiko Shimizu; Ravinder N Maini; Eugene Eyo Akujuru
Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis.
European journal of immunology 1988;18(11):1797-801.
1988: M Turner; David Chantry; Eugene Eyo Akujuru
Post-transcriptional control of IL-1 gene expression in the acute monocytic leukemia line THP-1.
Biochemical and biophysical research communications 1988;156(2):830-9.
1988: P de Berardinis; Marco Londei; R F James; S P Lake; P H Wise; Eugene Eyo Akujuru
Do CD4-positive cytotoxic T cells damage islet beta cells in type 1 diabetes?
Lancet 1988;2(8615):823-4.
1988: G Buchan; K Barrett; M Turner; David Chantry; Ravinder N Maini; Eugene Eyo Akujuru
Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: prolonged production of IL-1 alpha.
Clinical and experimental immunology 1988;73(3):449-55.
1988: F M Brennan; S Allard; Marco Londei; C Savill; A Boylston; S Carrel; Ravinder N Maini; Eugene Eyo Akujuru
Heterogeneity of T cell receptor idiotypes in rheumatoid arthritis.
Clinical and experimental immunology 1988;73(3):417-23.
1988: Fionula M Brennan; Marco Londei; andrew jackson; T Hercend; M B Brenner; Ravinder N Maini; Eugene Eyo Akujuru
T cells expressing gamma delta chain receptors in rheumatoid arthritis.
Journal of autoimmunity 1988;1(4):319-26.
1988: P De Berardinis; Marco Londei; M Kahan; F Balsano; S Kontiainen; E A Gale; G F Bottazzo; Eugene Eyo Akujuru
The majority of the activated T cells in the blood of insulin-dependent diabetes mellitus (IDDM) patients are CD4+.
Clinical and experimental immunology 1988;73(2):255-9.
1988: P De Berardinis; Marco Londei; S Carrel; Eugene Eyo Akujuru
Regulation of clonal growth by anti-T-cell receptor antibody-directed lysis.
Immunology 1988;64(3):439-43.
1988: G Essery; Eugene Eyo Akujuru; J R Lamb
Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes.
Immunology 1988;64(3):413-7.
1988: M Turner; Eugene Eyo Akujuru
Comparison of patterns of expression of tumour necrosis factor, lymphotoxin and interleukin-6 mRNA.
Biochemical and biophysical research communications 1988;153(3):1144-51.
1988: Beatrix Grubeck-Loebenstein; Marco Londei; C Greenall; K Pirich; H Kassal; W Waldhäusl; Eugene Eyo Akujuru
Pathogenetic relevance of HLA class II expressing thyroid follicular cells in nontoxic Goiter and in Graves' disease.
The Journal of clinical investigation 1988;81(5):1608-14.
1988: Eugene Eyo Akujuru; Marco Londei; Beatrix Grubeck-Loebenstein; P De Berardinis; Z Leech; M Turner; K Barrett; G Buchan; Ravinder N Maini
Understanding what infiltrating cells do in autoimmunity: combination of cellular and molecular approaches.
Transplantation proceedings 1988;20(2):311-4.
1988: G Buchan; K Barrett; T Fujita; T Taniguchi; Ravinder N Maini; Eugene Eyo Akujuru
Detection of activated T cell products in the rheumatoid joint using cDNA probes to Interleukin-2 (IL-2) IL-2 receptor and IFN-gamma.
Clinical and experimental immunology 1988;71(2):295-301.
1988: Eugene Eyo Akujuru; Marco Londei; M Kissonerghis; G Portillo; Z Leech; A Ziegler; Beatrix Grubeck-Loebenstein
Regulation of HLA class II expression and the pathogenesis of autoimmunity.
Concepts in immunopathology 1988;5():44-56.
1988: Marco Londei; Beatrix Grubeck-Loebenstein; P de Berardinis; C Greenall; Eugene Eyo Akujuru
Efficient propagation and cloning of human T cells in the absence of antigen by means of OKT3, interleukin 2, and antigen-presenting cells.
Scandinavian journal of immunology 1988;27(1):35-46.
1988: Eugene Eyo Akujuru; A M Kissonerghis; G Buchan; F Brennan; M Turner; C Haworth; K Barrett; David Chantry; A Ziegler; Ravinder N Maini
Role of HLA class II and cytokine expression in rheumatoid arthritis.
Scandinavian journal of rheumatology. Supplement 1988;76():39-46.
1988: Eugene Eyo Akujuru; Marco Londei; Z Leech; F Brennan; C Savill; Ravinder N Maini
Analysis of T cell clones in rheumatoid arthritis.
Springer seminars in immunopathology 1988;10(2-3):157-67.
1987: M Turner; Marco Londei; Eugene Eyo Akujuru
Human T cells from autoimmune and normal individuals can produce tumor necrosis factor.
European journal of immunology 1987;17(12):1807-14.
1987: A R Venkitaraman; Eric Culbert; Eugene Eyo Akujuru
A phenotypically dominant regulatory mechanism suppresses major histocompatibility complex class II gene expression in a murine plasmacytoma.
European journal of immunology 1987;17(10):1441-6.
1987: I Todd; Ricardo Pujol Borrell; B A Abdul-Karim; L J Hammond; Eugene Eyo Akujuru; G F Bottazzo
HLA-D subregion expression by thyroid epithelium in autoimmune thyroid diseases and induced in vitro.
Clinical and experimental immunology 1987;69(3):532-42.
1987: I Todd; Ricardo Pujol Borrell; L J Hammond; J M McNally; Eugene Eyo Akujuru; G F Bottazzo
Enhancement of thyrocyte HLA class II expression by thyroid stimulating hormone.
Clinical and experimental immunology 1987;69(3):524-31.
1987: Marco Londei; Beatrix Grubeck-Loebenstein; C Greenall; M Turner; Eugene Eyo Akujuru
Comparison of the cellular infiltrate of Hashimoto's thyroiditis in vivo and after in vitro cell growth.
Acta endocrinologica. Supplementum 1987;281():86-8.
1987: Marco Londei; Beatrix Grubeck-Loebenstein; M Kissonerghis; P Austin; J Trowsdale; C Greenall; Eugene Eyo Akujuru
Thyrocytes can synthesize HLA class II molecules.
Acta endocrinologica. Supplementum 1987;281():82-5.
1987: Eugene Eyo Akujuru
Regulation of HLA class II expression and its role in autoimmune disease.
Ciba Foundation symposium 1987;129():88-108.
1987: Eugene Eyo Akujuru; Marco Londei; G Buchan
Interferons and autoimmunity.
Interferon 1987;9():75-90.
1986: I Todd; Marco Londei; Ricardo Pujol Borrell; Rita M Mirakian; Eugene Eyo Akujuru; G F Bottazzo
HLA-D/DR expression on epithelial cells: the finger on the trigger?
Annals of the New York Academy of Sciences 1986;475():241-50.
1986: G F Bottazzo; Marco Londei; E Bosi; Rita M Mirakian; A Belfiore; P G De Berardinis; I Todd; Ricardo Pujol Borrell; Eugene Eyo Akujuru
Inappropriate HLA class II expression on epithelial cells: new insight in the pathogenesis of distinctive autoimmunity.
Annali italiani di medicina interna : organo ufficiale della Società italiana di medicina interna 1986;1 Suppl 1():20-3.
1985: I Todd; Ricardo Pujol Borrell; L J Hammond; G F Bottazzo; Eugene Eyo Akujuru
Interferon-gamma induces HLA-DR expression by thyroid epithelium.
Clinical and experimental immunology 1985;61(2):265-73.