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Alex Bossers

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Fang Tang; Alex Bossers; FL Harders; Chengping Lu; Hilde Smith
Complete Genome Sequence of the Streptococcus suis Temperate Bacteriophage ϕNJ2.
Hicham Filali; FL Harders; Inmaculada Martin-Burriel; Carmen Serrano; luis varona; Cristina Acín; Juan José Badiola; Alex Bossers; Rosa Bolea
Medulla oblongata transcriptome changes during presymptomatic natural scrapie and their association with prion-related lesions.
Jorg G Jacobs; P Berthon; Alex Bossers; F Lantier; Isabelle Lantier; S McCutcheon; H Rezaei; Theodoros Sklaviadis; L J M van Keulen; Fred G van Zijderveld; J P M Langeveld
Proteinase K-resistant material in ARR/VRQ sheep brain affected with classical scrapie is composed mainly of VRQ prion protein.

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All Publications

2013: Fang Tang; Alex Bossers; FL Harders; Chengping Lu; Hilde Smith
Complete Genome Sequence of the Streptococcus suis Temperate Bacteriophage ϕNJ2.
Genome announcements 2013;1(1):.
2012: Hicham Filali; FL Harders; Inmaculada Martin-Burriel; Carmen Serrano; luis varona; Cristina Acín; Juan José Badiola; Alex Bossers; Rosa Bolea
Medulla oblongata transcriptome changes during presymptomatic natural scrapie and their association with prion-related lesions.
BMC genomics 2012;13():399.
2011: Jorg G Jacobs; P Berthon; Alex Bossers; F Lantier; Isabelle Lantier; S McCutcheon; H Rezaei; Theodoros Sklaviadis; L J M van Keulen; Fred G van Zijderveld; J P M Langeveld
Proteinase K-resistant material in ARR/VRQ sheep brain affected with classical scrapie is composed mainly of VRQ prion protein.
Journal of virology 2011;85(23):12537-46.
2011: Alan Rigter; Jan P M Langeveld; Jan Priem; Alex Bossers
Prion protein self-interaction in prion disease therapy approaches.
The Veterinary quarterly 2011;31(3):115-28.
2011: Jan P M Langeveld; Ines Rammel; Fred G van Zijderveld; Alex Bossers; Aart Davidse; Jo H F Erkens; Jorg G Jacobs; Hermann Schildorfer
Four independent molecular prion protein parameters for discriminating new cases of C, L, and h bovine spongiform encephalopathy in cattle.
Journal of clinical microbiology 2011;49(8):3026-8.
2011: M B Melchior; TJ Hagenaars; A Davidse; L J M van Keulen; Alex Bossers; Fred G van Zijderveld
[Active surveillance for scrapie in the Netherlands: effect of a breeding programme on the prevalence of scrapie in sheep (2002-2010)?].
Tijdschrift voor diergeneeskunde 2011;136(2):84-93.
2011: Wilfred Goldmann; Lorenzo González; David Parnham; Kelly Ryan; Ginny Saunders; Paula Stewart; Otto Windl; Rosa Xicohtencatl; Alex Bossers; Nora Fernandez; James Foster
Caprine prion gene polymorphisms are associated with decreased incidence of classical scrapie in goat herds in the United Kingdom.
Veterinary research 2011;42(1):110.
2011: Hicham Filali; Inmaculada Martin-Burriel; Frank Harders; luis varona; Jaber Lyahyai; Pilar Zaragoza; Martí Pumarola; Juan José Badiola; Alex Bossers; Rosa Bolea
Gene expression profiling and association with prion-related lesions in the medulla oblongata of symptomatic natural scrapie animals.
PloS one 2011;6(5):e19909.
2011: Jorg G Jacobs; M Sauer; L J M van Keulen; Y Tang; Alex Bossers; Jan P M Langeveld
Differentiation of ruminant transmissible spongiform encephalopathy isolate types, including bovine spongiform encephalopathy and CH1641 scrapie.
The Journal of general virology 2011;92(Pt 1):222-32.
2010: Alan Rigter; Jan P M Langeveld; Fred G van Zijderveld; Alex Bossers
Prion protein self-interactions: a gateway to novel therapeutic strategies?
Vaccine 2010;28(49):7810-23.
2010: Steven J van Beurden; Alex Bossers; Michal H A Voorbergen-Laarman; Olga L M Haenen; Sander Peters; Marleen H C Abma-Henkens; Ben P H Peeters; Peter J M Rottier; Marc Y Engelsma
Complete genome sequence and taxonomic position of anguillid herpesvirus 1.
The Journal of general virology 2010;91(Pt 4):880-7.
2010: TJ Hagenaars; Marielle B Melchior; Alex Bossers; Aart Davidse; Bas Engel; Fred G van Zijderveld
Scrapie prevalence in sheep of susceptible genotype is declining in a population subject to breeding for resistance.
BMC veterinary research 2010;6():25.
2010: Marielle B Melchior; Jack J Windig; TJ Hagenaars; Alex Bossers; Aart Davidse; Fred G van Zijderveld
Eradication of scrapie with selective breeding: are we nearly there?
BMC veterinary research 2010;6():24.
2009: Gabriele Vaccari; Cynthia H Panagiotidis; Cristina Acin; Simone Peletto; Francis Barillet; Pierluigi Acutis; Alex Bossers; Jan Langeveld; Lucien van Keulen; Theodoros Sklaviadis; Juan J Badiola; Olivier Andreéoletti; Martin H Groschup; Umberto Agrimi; James Foster; Wilfred Goldmann
State-of-the-art review of goat TSE in the European Union, with special emphasis on PRNP genetics and epidemiology.
Veterinary research 2009;40(5):48.
2009: Christina D Orrú; Jason M Wilham; Andrew G Hughson; Lynne D Raymond; Kristin L McNally; Alex Bossers; Ciriaco Ligios; Byron Caughey
Human variant Creutzfeldt-Jakob disease and sheep scrapie PrP(res) detection using seeded conversion of recombinant prion protein.
Protein engineering, design & selection : PEDS 2009;22(8):515-21.
2009: Alan Rigter; Jan Priem; Drophatie Timmers-Parohi; Jan P M Langeveld; Fred G van Zijderveld; Alex Bossers
Prion protein self-peptides modulate prion interactions and conversion.
BMC biochemistry 2009;10():29.
2009: Alan Rigter; Jan Priem; Drophatie Timmers-Parohi; Jan P M Langeveld; Alex Bossers
Mapping functional prion-prion protein interaction sites using prion protein based peptide-arrays.
Methods in molecular biology (Clifton, N.J.) 2009;570():257-71.
2008: Lucien J M van Keulen; Alex Bossers; Fred van Zijderveld
TSE pathogenesis in cattle and sheep.
Veterinary research 2008;39(4):24.
2008: P L Acutis; S Colussi; G Santagada; C Laurenza; M G Maniaci; M V Riina; S Peletto; Wilfred Goldmann; Alex Bossers; M Caramelli; I Cristoferi; S Maione; P Sacchi; R Rasero
Genetic variability of the PRNP gene in goat breeds from Northern and Southern Italy.
Journal of applied microbiology 2008;104(6):1782-9.
2008: L J M van Keulen; M E W Vromans; C H Dolstra; Alex Bossers; F G van Zijderveld
Pathogenesis of bovine spongiform encephalopathy in sheep.
Archives of virology 2008;153(3):445-53.
2007: Kimberly Meade-White; Brent Race; Matthew J Trifilo; Alex Bossers; Cynthia Favara; Rachel LaCasse; Michael Miller; Elizabeth Williams; Michael B A Oldstone; Richard E Race; Bruce Chesebro
Resistance to chronic wasting disease in transgenic mice expressing a naturally occurring allelic variant of deer prion protein.
Journal of virology 2007;81(9):4533-9.
2007: A C B de Lima; Alex Bossers; Carlos Souza; Sonia M P Oliveira; Diana M Oliveira
PrP genotypes in a pedigree flock of Santa Inês sheep.
The Veterinary record 2007;160(10):336-7.
2007: Alan Rigter; Jan P M Langeveld; Drophatie Timmers-Parohi; Jorg G Jacobs; Peter Moonen; Alex Bossers
Mapping of possible prion protein self-interaction domains using peptide arrays.
BMC biochemistry 2007;8():6.
2006: Pierluigi Acutis; Alex Bossers; J Priem; Maria Vittoria Riina; Simone Peletto; Maria Mazza; Cristina Casalone; Gianluigi Forloni; Giuseppe Ru; Maria Caramelli
Identification of prion protein gene polymorphisms in goats from Italian scrapie outbreaks.
The Journal of general virology 2006;87(Pt 4):1029-33.
2006: Jan P M Langeveld; Jorg G Jacobs; Jo H F Erkens; Alex Bossers; Fred G van Zijderveld; L J M van Keulen
Rapid and discriminatory diagnosis of scrapie and BSE in retro-pharyngeal lymph nodes of sheep.
BMC veterinary research 2006;2():19.
2005: Alan Rigter; Alex Bossers
Sheep scrapie susceptibility-linked polymorphisms do not modulate the initial binding of cellular to disease-associated prion protein prior to conversion.
The Journal of general virology 2005;86(Pt 9):2627-34.
2004: Pierluigi Acutis; L Sbaiz; F Verburg; Maria Vittoria Riina; Giuseppe Ru; G Moda; Maria Caramelli; Alex Bossers
Low frequency of the scrapie resistance-associated allele and presence of lysine-171 allele of the prion protein gene in Italian Biellese ovine breed.
The Journal of general virology 2004;85(Pt 10):3165-72.
2004: C M A Thuring; Jo H F Erkens; Jorg G Jacobs; Alex Bossers; L J M van Keulen; G Jan Garssen; Fred G van Zijderveld; S J Ryder; Martin H Groschup; Torres Sweeney; Jan P M Langeveld
Discrimination between scrapie and bovine spongiform encephalopathy in sheep by molecular size, immunoreactivity, and glycoprofile of prion protein.
Journal of clinical microbiology 2004;42(3):972-80.
2003: Jan P M Langeveld; Jeng-Jie Wang; Dick F M van de Wiel; Giles C Shih; G Jan Garssen; Alex Bossers; Jason C H Shih
Enzymatic degradation of prion protein in brain stem from infected cattle and sheep.
The Journal of infectious diseases 2003;188(11):1782-9.
2003: Alex Bossers; Alan Rigter; Ruth de Vries; Mari A Smits
In vitro conversion of normal prion protein into pathologic isoforms.
Clinics in laboratory medicine 2003;23(1):227-47.
2000: Gregory J Raymond; Alex Bossers; Lynne D Raymond; K I O'Rourke; Linda E McHolland; P K Bryant; Michael W Miller; Elizabeth S Williams; M Smits; Byron Caughey
Evidence of a molecular barrier limiting susceptibility of humans, cattle and sheep to chronic wasting disease.
The EMBO journal 2000;19(17):4425-30.
2000: G Jan Garssen; L J M van Keulen; C F Farquhar; Mari A Smits; Jorg G Jacobs; Alex Bossers; Rob H Meloen; Jan P M Langeveld
Applicability of three anti-PrP peptide sera including staining of tonsils and brainstem of sheep with scrapie.
Microscopy research and technique 2000;50(1):32-9.
2000: Alex Bossers; Ruth de Vries; Mari A Smits
Susceptibility of sheep for scrapie as assessed by in vitro conversion of nine naturally occurring variants of PrP.
Journal of virology 2000;74(3):1407-14.
1999: Alex Bossers; FL Harders; Mari A Smits
PrP genotype frequencies of the most dominant sheep breed in a country free from scrapie.
Archives of virology 1999;144(4):829-34.
1997: Mari A Smits; Alex Bossers; Bram Schreuder
Prion protein and scrapie susceptibility.
The Veterinary quarterly 1997;19(3):101-5.
1997: Gregory J Raymond; James Hope; David Kocisko; Suzette A Priola; Lynne D Raymond; Alex Bossers; James Ironside; Robert G Will; S G Chen; R B Petersen; Pierluigi Gambetti; Richard Rubenstein; Mari A Smits; Peter T Lansbury; Byron Caughey
Molecular assessment of the potential transmissibilities of BSE and scrapie to humans.
Nature 1997;388(6639):285-8.
1997: Alex Bossers; Gregory J Raymond; Byron Caughey; Ruth de Vries; Mari A Smits
Scrapie susceptibility-linked polymorphisms modulate the in vitro conversion of sheep prion protein to protease-resistant forms.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):4931-6.
1996: PA van Rijn; Alex Bossers; G Wensvoort; R J M Moormann
Classical swine fever virus (CSFV) envelope glycoprotein E2 containing one structural antigenic unit protects pigs from lethal CSFV challenge.
The Journal of general virology 1996;77 ( Pt 11)():2737-45.
1996: Alex Bossers; Bram Schreuder; I H Muileman; P B Belt; Mari A Smits
PrP genotype contributes to determining survival times of sheep with natural scrapie.
The Journal of general virology 1996;77 ( Pt 10)():2669-73.