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Charles Mullighan

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Heng Xu; Wenjian Yang; Deepa Bhojwani; W Paul Bowman; Esteban González Burchard; Bruce M Camitta; William L Carroll; Cheng Cheng; Michael Dean; Meenakshi Devidas; Celeste Eng; William E Evans; Yiping Fan; Stephen P Hunger; Scott Huntsman; Mignon L Loh; Paul L Martin; Charles G Mullighan; Deqing Pei; Virginia Perez-Andreu; Ching-Hon Pui; Mary V Relling; Paul Scheet; Dara G Torgerson; Cheryl L Willman; Naomi J Winick; Jun J Yang
Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.
Julie Hussin; Youssef Idaghdour; Mathieu Larivière; Jing Ma; Charles G Mullighan; Virginie Saillour; Daniel Sinnett; Jean-François Spinella; Lei Wei; Jinghui Zhang; Vanessa Bruat; Stephan Busche; Ferran Casals; Thibault de Malliard; James R Downing; Greg Gibson; Jean-Christophe Grenier; Jasmine Healy; Linda Holmfeldt; Gregor Andelfinger; Anna Andersson; Philip Awadalla
Rare allelic forms of PRDM9 associated with childhood leukemogenesis.
Antonija Kreso; Jing Ma; John McPherson; Charles G Mullighan; Karen Ng; Faiyaz Notta; Catherine A O'Brien; Aaron Pollett; Darryl Shibata; Peter van Galen; Erno Wienholds; Andrew M K Brown; Cyrille Dunant; Steven Gallinger; Olga I Gan; John E Dick
Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer.

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2013: Heng Xu; Wenjian Yang; Deepa Bhojwani; W Paul Bowman; Esteban González Burchard; Bruce M Camitta; William L Carroll; Cheng Cheng; Michael Dean; Meenakshi Devidas; Celeste Eng; William E Evans; Yiping Fan; Stephen P Hunger; Scott Huntsman; Mignon L Loh; Paul L Martin; Charles G Mullighan; Deqing Pei; Virginia Perez-Andreu; Ching-Hon Pui; Mary V Relling; Paul Scheet; Dara G Torgerson; Cheryl L Willman; Naomi J Winick; Jun J Yang
Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.
Journal of the National Cancer Institute 2013;105(10):733-42.
2013: Julie Hussin; Youssef Idaghdour; Mathieu Larivière; Jing Ma; Charles G Mullighan; Virginie Saillour; Daniel Sinnett; Jean-François Spinella; Lei Wei; Jinghui Zhang; Vanessa Bruat; Stephan Busche; Ferran Casals; Thibault de Malliard; James R Downing; Greg Gibson; Jean-Christophe Grenier; Jasmine Healy; Linda Holmfeldt; Gregor Andelfinger; Anna Andersson; Philip Awadalla
Rare allelic forms of PRDM9 associated with childhood leukemogenesis.
Genome research 2013;23(3):419-30.
2013: Antonija Kreso; Jing Ma; John McPherson; Charles G Mullighan; Karen Ng; Faiyaz Notta; Catherine A O'Brien; Aaron Pollett; Darryl Shibata; Peter van Galen; Erno Wienholds; Andrew M K Brown; Cyrille Dunant; Steven Gallinger; Olga I Gan; John E Dick
Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer.
Science (New York, N.Y.) 2013;339(6119):543-8.
2013: Mignon L Loh; Charles G Mullighan; Debbie Payne-Turner; Elizabeth A Raetz; Kathryn Roberts; Malcolm Smith; Cheryl L Willman; Naomi Winick; Brent Wood; Gang Wu; Jinghui Zhang; Jared Becksfort; Michael J Borowitz; Paul Bowman; Kenneth H Buetow; William L Carroll; I-Ming Chen; Xiang Chen; Meenakshi Devidas; James R Downing; Michael Edmonson; Daniela S Gerhard; Richard C Harvey; Huining Kang; Eric Larsen; Stephen P Hunger
Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project.
Blood 2013;121(3):485-8.
2012: Shuyang Yu; Oksana Zagorodna; Dong-Mei Zhao; Xinyuan Zhou; Yoshifumi Yokota; Shann-Ching Chen; Xuefang Jing; C Michael Knudson; Chengyu Liu; David K Meyerholz; Charles G Mullighan; Farrah C Steinke; Hai-Hui Xue
The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy.
Immunity 2012;37(5):813-26.
2012: Shannon L Maude; Charles G Mullighan; Kathryn G Roberts; Alix E Seif; Cecilia Sheen; Sarah K Tasian; Tiffaney Vincent; Cheryl L Willman; David Maxwell Barrett; I-Ming Chen; J Racquel Collins; Jordan S Fridman; Stephan A Grupp; Junior W Hall; Richard C Harvey; Stephen P Hunger; Mignon L Loh; David Teachey
Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia.
Blood 2012;120(17):3510-8.
2012: Charles G Mullighan
Molecular genetics of B-precursor acute lymphoblastic leukemia.
The Journal of clinical investigation 2012;122(10):3407-15.
2012: Ching-Hon Pui; William E Evans; Charles G Mullighan; Mary V Relling
Pediatric acute lymphoblastic leukemia: where are we going and how do we get there?
Blood 2012;120(6):1165-74.
2012: Sarah K Tasian; Cheryl L Willman; Brent L Wood; Charles G Mullighan; Michael J Borowitz; I-Ming Chen; Michelle Y Doral; Julie M Gastier-Foster; Richard C Harvey; Stephen P Hunger; Mignon L Loh
Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia.
Blood 2012;120(4):833-42.
2012: Mignon L Loh; Charles G Mullighan
Advances in the genetics of high-risk childhood B-progenitor acute lymphoblastic leukemia and juvenile myelomonocytic leukemia: implications for therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(10):2754-67.
2012: I-Ming Chen; Catherine E Cottrell; Meenakshi Devidas; Julie M Gastier-Foster; Richard C Harvey; Stephen P Hunger; Huining Kang; Mignon L Loh; Charles G Mullighan; Debbie Payne-Turner; D Jeanette Pullen; Gregory H Reaman; Shalini Reshmi; Sarah K Tasian; Walker Wharton; Michael J Borowitz; W Paul Bowman; Bruce M Camitta; Andrew J Carroll; William L Carroll; Naomi J Winick; Cheryl L Willman
Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group study.
Blood 2012;119(15):3512-22.
2012: Gang Wu; Junyuan Zhang; Jinghui Zhang; Suzanne J Baker; Jared Becksfort; Alberto Broniscer; Li Ding; James R Downing; Michael A Dyer; David W Ellison; Amar Gajjar; Richard J Gilbertson; Robert Huether; Charles Lu; Elaine R Mardis; Troy A McEachron; Charles G Mullighan; Matthew Parker; Barbara S Paugh; Chunxu Qu; Richard K Wilson
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas.
Nature genetics 2012;44(3):251-3.
2012: Jinghui Zhang; Jan Cools; Deqing Pei; Sheila A Shurtleff; Timothy J Ley; Michael I Barbato; Stefan Roberts; Faiyaz Notta; Jianmin Wang; Richard K Wilson; Stephen P Hunger; Elaine R Mardis; Susana C Raimondi; Charles Lu; Sue L Heatley; Dario Campana; Kolja Eppert; Kristin A Shimano; Li Ding; Ching-Hon Pui; Xiang Chen; Pankaj Gupta; Stanley B Pounds; Mignon L Loh; J Racquel Collins-Underwood; Matthew Parker; Stuart S Winter; John E Dick; Elisa Laurenti; Michelle L Hermston; Jing Ma; Maria Kleppe; Debbie Payne-Turner; Meenakshi Devidas; KP Dunsmore; Anatoly Ulyanov; Robert Huether; Daniel J McGoldrick; Xin Hong; Stephen Espy; Jared Becksfort; Michael Rusch; Lei Wei; Sergei Doulatov; Kathryn G Roberts; Shann-Ching Chen; Giuseppe Basso; Guangchun Song; David J Dooling; Cheng Cheng; Kimberly J Johnson; Robert S Fulton; Brent Wood; Kiran Chand Bobba; David Zhao; Richard W Kriwacki; Christopher C Harris; Lucinda L Fulton; Daniel Alford; John C Obenauer; Linda Holmfeldt; Clayton W Naeve; Elaine Coustan-Smith; William E Evans; Gang Wu; Kerri Ochoa; James R Downing; John Easton; Charles G Mullighan
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.
Nature 2012;481(7380):157-63.
2012: Charles G Mullighan
The molecular genetic makeup of acute lymphoblastic leukemia.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2012;2012():389-96.
2011: Charles G Mullighan
Genomic profiling of B-progenitor acute lymphoblastic leukemia.
Best practice & research. Clinical haematology 2011;24(4):489-503.
2011: Katherine E Berquam-Vrieze; Benjamin T Brett; Neal G Copeland; Linda Holmfeldt; Nancy A Jenkins; C Michael Knudson; Jing Ma; David K Meyerholz; Charles G Mullighan; Kishore Nannapaneni; Todd E Scheetz; Oksana Zagorodna; Adam J Dupuy
Cell of origin strongly influences genetic selection in a mouse model of T-ALL.
Blood 2011;118(17):4646-56.
2011: Alejandro Gutierrez; Linda Holmfeldt; Stephen P Hunger; Alex Kentsis; Frederick W Alt; Shann-Ching Chen; Lynda Chin; Suzanne E Dahlberg; James R Downing; Charles G Mullighan; Donna Neuberg; Alexei Protopopov; Stephen E Sallan; Takaomi Sanda; Lewis B Silverman; Stuart S Winter; Shan Zha; Jianhua Zhang; A Thomas Look
The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia.
Blood 2011;118(15):4169-73.
2011: L A Rudner; Joshua Schiffman; A C H Smith; Nikolaus S Trede; D F Bradley; K H Brown; K P Dobrinski; J M Downie; J R Downing; M I Garcia; A Gutierrez; C Lee; A Thomas Look; N D Meeker; Charles G Mullighan; J K Frazer
Shared acquired genomic changes in zebrafish and human T-ALL.
Oncogene 2011;30(41):4289-96.
2011: Barthelemy Diouf; James R Downing; Siying Chen; Cheng Cheng; Qing Cheng; Meyling Cheok; Yiping Fan; Hui Geng; Peggy Hsieh; Natalia F Krynetskaia; Evgeny Y Krynetskiy; Charles G Mullighan; Deqing Pei; Ching-Hon Pui; Mary V Relling; William E Thierfelder; Wenjian Yang; William E Evans
Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells.
Nature medicine 2011;17(10):1298-303.
2011: A K Andersson; Z Cai; A S Lemoff; J A Lynch; D W Miller; Charles G Mullighan; Stanley Pounds; Ina Radtke; Susana C Raimondi; Raul C Ribeiro; Jeffrey E Rubnitz; J D Schuetz; Brenda A Schulman; Sheila A Shurtleff; B Yan; J Zhang; James R Downing
IDH1 and IDH2 mutations in pediatric acute leukemia.
Leukemia 2011;25(10):1570-7.
2011: Jinghui Zhang; Mignon L Loh; Charles G Mullighan; Gregory H Reaman; Mary V Relling; Malcolm A Smith; Cheryl L Willman; Gang Wu; W Paul Bowman; Kenneth H Buetow; Bruce M Camitta; William L Carroll; I-Ming Chen; Xiang Chen; Meenakshi Devidas; James R Downing; Michael Edmonson; Daniela S Gerhard; Richard C Harvey; Stephen P Hunger
Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group.
Blood 2011;118(11):3080-7.
2011: Laura Pasqualucci; Raul Rabadan; Davide Rossi; Vladimir Trifonov; Victoria A Wells; Govind Bhagat; Amy Chadburn; Joseph Chan; Annalisa Chiarenza; Oliver Elliot; Giulia Fabbri; Gianluca Gaidano; Adina Grunn; Jing Ma; Monica Messina; Charles G Mullighan; Riccardo Dalla-Favera
Analysis of the coding genome of diffuse large B-cell lymphoma.
Nature genetics 2011;43(9):830-7.
2011: Jianmin Wang; Lei Wei; Richard K Wilson; David Zhao; Ken Chen; Li Ding; James R Downing; John Easton; Xian Fan; Christopher C Harris; Sue L Heatley; Linda Holmfeldt; Jing Ma; Elaine R Mardis; Charles G Mullighan; Clayton W Naeve; John C Obenauer; Debbie Payne-Turner; Stefan Roberts; Michael C Rusch; Jinghui Zhang
CREST maps somatic structural variation in cancer genomes with base-pair resolution.
Nature methods 2011;8(8):652-4.
2011: Louise van der Weyden; Anne E Corcoran; George Giotopoulos; Mel F Greaves; Brian J Huntly; Jun Kong; Louise S Matheson; Charles G Mullighan; Alistair G Rust; Frederik W van Delft; David J Adams
Modeling the evolution of ETV6-RUNX1-induced B-cell precursor acute lymphoblastic leukemia in mice.
Blood 2011;118(4):1041-51.
2011: Julia Hauer; Sven Kracker; Marc Lelorc'h; Estelle Morillon; Charles G Mullighan; Serge Romana; Daniela Tiedau; Gary Wang; Arndt Borkhardt; Amine Boudil; Nicole Brousse; Julie Bruneau; Frederic D Bushmann; Alain Fischer; Salima Hacein-Bey-Abina; Marina Cavazzana-Calvo
Loss of p19Arf in a Rag1(-/-) B-cell precursor population initiates acute B-lymphoblastic leukemia.
Blood 2011;118(3):544-53.
2011: Linda Holmfeldt; Charles G Mullighan
The role of TET2 in hematologic neoplasms.
Cancer cell 2011;20(1):1-2.
2011: Giulia Fabbri; Marco Fangazio; Robin Foá; Francesco Forconi; Luca Arcaini; Francesco Bertoni; Daniela Capello; Stefania Cresta; Riccardo Dalla-Favera; Ernesto Gargiulo; Valter Gattei; Adina Grunn; Anna Guarini; Hossein Khiabanian; Luigi M Larocca; Luca Laurenti; Jing Ma; Marasca Roberto; Sara Monti; Charles G Mullighan; David Oscier; Laura Pasqualucci; Marco Paulli; Raul Rabadan; Silvia Rasi; Davide Rossi; Vladimir Trifonov; Gianluca Gaidano
Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation.
The Journal of experimental medicine 2011;208(7):1389-401.
2011: Stephen P Hunger; Elizabeth A Raetz; Mignon L Loh; Charles G Mullighan
Improving outcomes for high-risk ALL: translating new discoveries into clinical care.
Pediatric blood & cancer 2011;56(6):984-93.
2011: Charles G Mullighan; Jinghui Zhang; Lawryn H Kasper; Stephanie Lerach; Debbie Payne-Turner; Letha A Phillips; Sue L Heatley; Linda Holmfeldt; J Racquel Collins-Underwood; Jing Ma; Kenneth H Buetow; Ching-Hon Pui; Sharyn D Baker; Paul K Brindle; James R Downing
CREBBP mutations in relapsed acute lymphoblastic leukaemia.
Nature 2011;471(7337):235-9.
2011: Laura Pasqualucci; David Dominguez-Sola; Annalisa Chiarenza; Giulia Fabbri; Adina Grunn; Vladimir Trifonov; Lawryn H Kasper; Stephanie Lerach; Hongyan Tang; Jing Ma; Davide Rossi; Amy Chadburn; Vundavalli Murty; Charles G Mullighan; Gianluca Gaidano; Raul Rabadan; Paul K Brindle; Riccardo Dalla-Favera
Inactivating mutations of acetyltransferase genes in B-cell lymphoma.
Nature 2011;471(7337):189-95.
2011: Sankaranarayanan Kannan; Wendy Fang; Guangchun Song; Charles G Mullighan; Richard Hammitt; John McMurray; Patrick A Zweidler-McKay
Notch/HES1-mediated PARP1 activation: a cell type-specific mechanism for tumor suppression.
Blood 2011;117(10):2891-900.
2011: Kathryn G Roberts; Charles G Mullighan
How new advances in genetic analysis are influencing the understanding and treatment of childhood acute leukemia.
Current opinion in pediatrics 2011;23(1):34-40.
2011: Charles G Mullighan
New strategies in acute lymphoblastic leukemia: translating advances in genomics into clinical practice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(3):396-400.
2011: Faiyaz Notta; Charles G Mullighan; Jean C Y Wang; Armando Poeppl; Sergei Doulatov; Letha A Phillips; Jing Ma; Mark D Minden; James R Downing; John E Dick
Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells.
Nature 2011;469(7330):362-7.
2011: Charles G Mullighan
Single nucleotide polymorphism microarray analysis of genetic alterations in cancer.
Methods in molecular biology (Clifton, N.J.) 2011;730():235-58.
2011: J Racquel Collins-Underwood; Charles G Mullighan
Genetic alterations targeting lymphoid development in acute lymphoblastic leukemia.
Current topics in developmental biology 2011;94():171-96.
2011: Charles G Mullighan; Effie Petersdorf; Stella M Davies; John DiPersio
From trees to the forest: genes to genomics.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2011;17(1 Suppl):S52-7.
2010: Richard C Harvey; Charles G Mullighan; Xuefei Wang; Kevin K Dobbin; George S Davidson; Edward J Bedrick; I-Ming Chen; Susan R Atlas; Huining Kang; Kerem Ar; Carla S Wilson; Walker Wharton; Maurice Murphy; Meenakshi Devidas; Andrew J Carroll; Michael J Borowitz; W Paul Bowman; James R Downing; Mary Relling; Jun Yang; Deepa Bhojwani; William L Carroll; Bruce Camitta; Gregory H Reaman; Malcolm Smith; Stephen P Hunger; Cheryl L Willman
Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome.
Blood 2010;116(23):4874-84.
2010: Charles G Mullighan
T-lineage lymphoblastic lymphoma and leukemia-a MASSive problem.
Cancer cell 2010;18(4):297-9.
2010: J R Collins-Underwood; Charles G Mullighan
Genomic profiling of high-risk acute lymphoblastic leukemia.
Leukemia 2010;24(10):1676-85.
2010: Linda Holmfeldt; Charles G Mullighan
PHF6 mutations in T-lineage acute lymphoblastic leukemia.
Pediatric blood & cancer 2010;55(4):595-6.
2010: Charles G Mullighan
Genetic variation and the risk of acute lymphoblastic leukemia.
Leukemia research 2010;34(10):1269-70.
2010: Lluis Espinosa; Severine Cathelin; Teresa D'Altri; Thomas Trimarchi; Alexander Statnikov; Jordi Guiu; Veronica Rodilla; Julia Inglés-Esteve; Josep F Nomdedeu; Beatriz Bellosillo; Carles Besses; Omar Abdel-Wahab; Nicole Kucine; Shao-Cong Sun; Guangchan Song; Charles G Mullighan; Ross Levine; Klaus Rajewsky; Iannis Aifantis; Anna Bigas
The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia.
Cancer cell 2010;18(3):268-81.
2010: Alejandro Gutierrez; Suzanne E Dahlberg; Donna S Neuberg; Jianhua Zhang; Ruta Grebliunaite; Takaomi Sanda; Alexei Protopopov; Valeria Tosello; Jeffery L Kutok; Richard Larson; Michael J Borowitz; Mignon L Loh; Adolfo Ferrando; Stuart S Winter; Charles G Mullighan; Lewis B Silverman; Lynda Chin; Stephen P Hunger; Stephen E Sallan; A Thomas Look
Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(24):3816-23.
2010: Richard C Harvey; Charles G Mullighan; I-Ming Chen; Walker Wharton; Fady M Mikhail; Andrew J Carroll; Huining Kang; Wei Liu; Kevin K Dobbin; Malcolm A Smith; William L Carroll; Meenakshi Devidas; W Paul Bowman; Bruce M Camitta; Gregory H Reaman; Stephen P Hunger; James R Downing; Cheryl L Willman
Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia.
Blood 2010;115(26):5312-21.
2010: Patricia Stow; Laura Key; Xiaohua Chen; Qiulu Pan; Geoffrey A Neale; Elaine Coustan-Smith; Charles G Mullighan; Yinmei Zhou; Ching-Hon Pui; Dario Campana
Clinical significance of low levels of minimal residual disease at the end of remission induction therapy in childhood acute lymphoblastic leukemia.
Blood 2010;115(23):4657-63.
2010: Huining Kang; I-Ming Chen; Carla S Wilson; Edward J Bedrick; Richard C Harvey; Susan R Atlas; Meenakshi Devidas; Charles G Mullighan; Xuefei Wang; Maurice Murphy; Kerem Ar; Walker Wharton; Michael J Borowitz; W Paul Bowman; Deepa Bhojwani; William L Carroll; Bruce M Camitta; Gregory H Reaman; Malcolm A Smith; James R Downing; Stephen P Hunger; Cheryl L Willman
Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia.
Blood 2010;115(7):1394-405.
2009: Charles G Mullighan; J Racquel Collins-Underwood; Letha A A Phillips; Michael G Loudin; Wei Liu; Jinghui Zhang; Jing Ma; Elaine Coustan-Smith; Richard C Harvey; Cheryl L Willman; Fady M Mikhail; Julia Meyer; Andrew J Carroll; Richard Williams; Jinjun Cheng; Nyla A Heerema; Giuseppe Basso; Andrea Pession; Ching-Hon Pui; Susana C Raimondi; Stephen P Hunger; James R Downing; William L Carroll; Karen Rabin
Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia.
Nature genetics 2009;41(11):1243-6.
2009: Charles G Mullighan
Mutations of NOTCH1, FBXW7, and prognosis in T-lineage acute lymphoblastic leukemia.
Haematologica 2009;94(10):1338-40.
2009: Mignon L Loh; Debbie S Sakai; Christian Flotho; Michelle Kang; Manfred Fliegauf; Sophie Archambeault; Charles G Mullighan; Leslie Chen; Eva Bergstraesser; Carlos E Bueso-Ramos; Peter D Emanuel; Henrik Hasle; Jean-Pierre J Issa; Marry M van den Heuvel-Eibrink; Franco Locatelli; Jan Stary; Monika M Trebo; Marcin Wlodarski; Marco Zecca; Kevin Shannon; Charlotte M Niemeyer
Mutations in CBL occur frequently in juvenile myelomonocytic leukemia.
Blood 2009;114(9):1859-63.
2009: Ina Radtke; Charles G Mullighan; Masami Ishii; Xiaoping Su; Jinjun Cheng; Jing Ma; Ramapriya Ganti; Zhongling Cai; Salil Goorha; Stanley B Pounds; Xueyuan Cao; Caroline Obert; Jianling Armstrong; Jinghui Zhang; Guangchun Song; Raul C Ribeiro; Jeffrey E Rubnitz; Susana C Raimondi; Sheila A Shurtleff; James R Downing
Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(31):12944-9.
2009: Charles G Mullighan
Genomic analysis of acute leukemia.
International journal of laboratory hematology 2009;31(4):384-97.
2009: Charles G Mullighan
TET2 mutations in myelodysplasia and myeloid malignancies.
Nature genetics 2009;41(7):766-7.
2009: Srinivas R Viswanathan; John T Powers; William Einhorn; Yujin Hoshida; Tony L Ng; Sara Toffanin; Maureen O'Sullivan; Jun Lu; Letha A Phillips; Victoria L Lockhart; Samar P Shah; Pradeep S Tanwar; Craig H Mermel; Rameen Beroukhim; Mohammad Azam; Jose Teixeira; Matthew Meyerson; Timothy P Hughes; Josep M Llovet; Jerald Radich; Charles G Mullighan; Todd R Golub; Poul H Sorensen; George Q Daley
Lin28 promotes transformation and is associated with advanced human malignancies.
Nature genetics 2009;41(7):843-8.
2009: Charles G Mullighan; James R Downing
Genome-wide profiling of genetic alterations in acute lymphoblastic leukemia: recent insights and future directions.
Leukemia 2009;23(7):1209-18.
2009: Charles G Mullighan; Jinghui Zhang; Richard C Harvey; J Racquel Collins-Underwood; Brenda A Schulman; Letha A Phillips; Sarah K Tasian; Mignon L Loh; Xiaoping Su; Wei Liu; Meenakshi Devidas; Susan R Atlas; I-Ming Chen; Robert J Clifford; Daniela S Gerhard; William L Carroll; Gregory H Reaman; Malcolm Smith; James R Downing; Stephen P Hunger; Cheryl L Willman
JAK mutations in high-risk childhood acute lymphoblastic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(23):9414-8.
2009: Daniel L Worthley; Andrew Ruszkiewicz; Ruth Davies; Sarah Moore; Ian Nivison-Smith; L Bik To; Peter Browett; Robyn Western; Simon Durrant; Jason So; Graeme P Young; Charles G Mullighan; Peter G Bardy; Michael Z Michael
Human gastrointestinal neoplasia-associated myofibroblasts can develop from bone marrow-derived cells following allogeneic stem cell transplantation.
Stem cells (Dayton, Ohio) 2009;27(6):1463-8.
2009: Hiroyuki Fujisaki; Harumi Kakuda; Chihaya Imai; Charles G Mullighan; Dario Campana
Replicative potential of human natural killer cells.
British journal of haematology 2009;145(5):606-13.
2009: Deborah French; Wenjian Yang; Cheng Cheng; Susana C Raimondi; Charles G Mullighan; James R Downing; William Evans; Ching-Hon Pui; Mary Relling
Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia.
Blood 2009;113(19):4512-20.
2009: Daniel L Worthley; Douglas F Johnson; Damon P Eisen; Melinda M Dean; Susan L Heatley; John-Paul Tung; Justin Scott; Robert T A Padbury; Hugh A Harley; Peter G Bardy; Peter W Angus; Charles G Mullighan
Donor mannose-binding lectin deficiency increases the likelihood of clinically significant infection after liver transplantation.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2009;48(4):410-7.
2009: Elaine Coustan-Smith; Charles G Mullighan; Mihaela Onciu; Frederick G. Behm; Susana C Raimondi; Deqing Pei; Cheng Cheng; Xiaoping Su; Jeffrey E Rubnitz; Giuseppe Basso; Andrea Biondi; Ching-Hon Pui; James R Downing; Dario Campana
Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia.
The lancet oncology 2009;10(2):147-56.
2009: Stan Pounds; Cheng Cheng; Charles G Mullighan; Susana C Raimondi; Sheila Shurtleff; James R Downing
Reference alignment of SNP microarray signals for copy number analysis of tumors.
Bioinformatics (Oxford, England) 2009;25(3):315-21.
2009: Charles G Mullighan; Xiaoping Su; Jinghui Zhang; Ina Radtke; Letha Phillips; Christopher B Miller; Jing Ma; Wei Liu; Cheng Cheng; Brenda A Schulman; Richard C Harvey; I-Ming Chen; Robert J Clifford; William L Carroll; Gregory Reaman; W Paul Bowman; Meenakshi Devidas; Daniela S Gerhard; Wenjian Yang; Mary Relling; Sheila A Shurtleff; Dario Campana; Michael J Borowitz; Ching-Hon Pui; Malcolm Smith; Stephen P Hunger; Cheryl L Willman; James R Downing
Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia.
The New England journal of medicine 2009;360(5):470-80.
2009: Charles G Mullighan; James R Downing
Global genomic characterization of acute lymphoblastic leukemia.
Seminars in hematology 2009;46(1):3-15.
2008: Charles G Mullighan; Letha Phillips; Xiaoping Su; Jing Ma; Christopher B Miller; Sheila A Shurtleff; James R Downing
Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia.
Science (New York, N.Y.) 2008;322(5906):1377-80.
2008: Charles G Mullighan
JAK2--a new player in acute lymphoblastic leukaemia.
Lancet 2008;372(9648):1448-50.
2008: Charles G Mullighan; Susan L Heatley; Silke Danner; Melinda M Dean; Kathleen Doherty; Uwe Hahn; Kenneth F Bradstock; Robyn Minchinton; Anthony P Schwarer; Jeff Szer; Peter G Bardy
Mannose-binding lectin status is associated with risk of major infection following myeloablative sibling allogeneic hematopoietic stem cell transplantation.
Blood 2008;112(5):2120-8.
2008: Charles G Mullighan; Richard Williams; James R Downing; Charles J Sherr
Failure of CDKN2A/B (INK4A/B-ARF)-mediated tumor suppression and resistance to targeted therapy in acute lymphoblastic leukemia induced by BCR-ABL.
Genes & development 2008;22(11):1411-5.
2008: Charles G Mullighan; James Downing
Ikaros and acute leukemia.
Leukemia & lymphoma 2008;49(5):847-9.
2008: Charles G Mullighan; Christopher B Miller; Ina Radtke; Letha Phillips; James Dalton; Jing Ma; Deborah White; Timothy P Hughes; Michelle M Le Beau; Ching-Hon Pui; Mary Relling; Sheila A Shurtleff; James R Downing
BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros.
Nature 2008;453(7191):110-4.
2007: Charles G Mullighan; A Kennedy; X Zhou; Ina Radtke; Letha Phillips; Sheila A Shurtleff; James R Downing
Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias.
Leukemia 2007;21(9):2000-9.
2007: Christian Flotho; Doris Steinemann; Charles G Mullighan; G Neale; K Mayer; Christian P Kratz; Brigitte Schlegelberger; James R Downing; Charlotte M Niemeyer
Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11.
Oncogene 2007;26(39):5816-21.
2007: Daniel L Worthley; Peter Bardy; David L Gordon; Charles G Mullighan
Mannose-binding lectin and gastric cancer.
International journal of cancer. Journal international du cancer 2007;120(12):2751-2; author reply 2750.
2007: Charles G Mullighan; Salil Goorha; Ina Radtke; Christopher B Miller; Elaine Coustan-Smith; James D Dalton; Kevin Girtman; Susan Mathew; Jing Ma; Stanley Pounds; Xiaoping Su; Ching-Hon Pui; Mary Relling; William Evans; Sheila A Shurtleff; James R Downing
Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia.
Nature 2007;446(7137):758-64.
2007: Daniel L Worthley; Charles G Mullighan; Melinda M Dean; David L Gordon; Peter Phillips; Sue Heatley; Graeme P Young; Peter Bardy
Mannose-binding lectin deficiency does not increase the prevalence of Helicobacter pylori seropositivity.
European journal of gastroenterology & hepatology 2007;19(2):147-52.
2007: Charles G Mullighan; Peter Bardy
New directions in the genomics of allogeneic hematopoietic stem cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2007;13(2):127-44.
2006: Charles G Mullighan; DIMITRIOS BOGDANOS; D Vergani; Peter Bardy
Cytochrome P450 1A2 is a target antigen in hepatitic graft-versus-host disease.
Bone marrow transplantation 2006;38(10):703-5.
2006: Daniel L Worthley; Peter Bardy; David L Gordon; Charles G Mullighan
Mannose-binding lectin and maladies of the bowel and liver.
World journal of gastroenterology : WJG 2006;12(40):6420-8.
2006: James R Downing; Charles G Mullighan
Tumor-specific genetic lesions and their influence on therapy in pediatric acute lymphoblastic leukemia.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2006;():118-22, 508.
2006: Charles G Mullighan; Effie W Petersdorf
Genomic polymorphism and allogeneic hematopoietic transplantation outcome.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2006;12(1 Suppl 1):19-27.
2005: Daniel L Worthley; Peter Bardy; Peter Angus; Hugh Harley; Charles G Mullighan
Mannose-binding lectin and liver transplantation.
Gastroenterology 2005;129(5):1805-6; author reply 1806-7.
2005: Daniel L Worthley; Peter Bardy; Charles G Mullighan
Mannose-binding lectin: biology and clinical implications.
Internal medicine journal 2005;35(9):548-55.
2005: Charles G Mullighan; Christian Flotho; James R Downing
Genomic assessment of pediatric acute leukemia.
Cancer journal (Sudbury, Mass.) 2005;11(4):268-82.
2004: Margaret F Annells; Prue H Hart; Charles G Mullighan; Sue Heatley; Jeffrey S Robinson; Peter Bardy; Helen M McDonald
Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth.
American journal of obstetrics and gynecology 2004;191(6):2056-67.
2004: Charles G Mullighan; Amanda Rischbieth; Elizabeth M Duncan; John V Lloyd
Acquired isolated factor VII deficiency associated with severe bleeding and successful treatment with recombinant FVIIa (NovoSeven).
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2004;15(4):347-51.
2004: Jim Jannes; Monica A Hamilton-Bruce; Louis S Pilotto; Brian J Smith; Charles G Mullighan; Peter Bardy; Simon A Koblar
Tissue plasminogen activator -7351C/T enhancer polymorphism is a risk factor for lacunar stroke.
Stroke; a journal of cerebral circulation 2004;35(5):1090-4.
2004: Charles G Mullighan; Sue Heatley; Kathleen V Doherty; Ferenc Szabo; Andrew Grigg; Timothy Hughes; Anthony P Schwarer; Jeff Szer; Brian D Tait; Bik To; Peter Bardy
Non-HLA immunogenetic polymorphisms and the risk of complications after allogeneic hemopoietic stem-cell transplantation.
Transplantation 2004;77(4):587-96.
2004: Charles G Mullighan; Peter Bardy
Mannose-binding lectin and infection following allogeneic hemopoietic stem cell transplantation.
Leukemia & lymphoma 2004;45(2):247-56.
2004: Charles G Mullighan; Sue Heatley; Sue Lester; Maureen Rischmueller; Tom P Gordon; Peter Bardy
Fas gene promoter polymorphisms in primary Sjögren's syndrome.
Annals of the rheumatic diseases 2004;63(1):98-101.
2003: karla helbig; Sue Heatley; RJ Harris; Charles G Mullighan; Peter Bardy; BP Marmion
Variation in immune response genes and chronic Q fever. Concepts: preliminary test with post-Q fever fatigue syndrome.
Genes and immunity 2003;4(1):82-5.
2002: Robyn Minchinton; Melinda M Dean; T R Clark; Sue Heatley; Charles G Mullighan
Analysis of the relationship between mannose-binding lectin (MBL) genotype, MBL levels and function in an Australian blood donor population.
Scandinavian journal of immunology 2002;56(6):630-41.
2002: Charles G Mullighan; Sue Heatley; Kathleen V Doherty; Ferenc Szabo; Andrew Grigg; Timothy P Hughes; Anthony P Schwarer; Jeff Szer; Brian D Tait; L Bik To; Peter Bardy
Mannose-binding lectin gene polymorphisms are associated with major infection following allogeneic hemopoietic stem cell transplantation.
Blood 2002;99(10):3524-9.
2001: Susan A Weston; Madhuri L Prasad; Charles G Mullighan; Helen Chapel; Elizabeth M Benson
Assessment of male CVID patients for mutations in the Btk gene: how many have been misdiagnosed?
Clinical and experimental immunology 2001;124(3):465-9.
2000: Charles G Mullighan; Sue Heatley; Peter Bardy; Sue Lester; Maureen Rischmueller; Tom P Gordon
Lack of association between mannose-binding lectin gene polymorphisms and primary Sjögren's syndrome.
Arthritis and rheumatism 2000;43(12):2851-2.
2000: Sara E Marshall; C Bordea; Neil A Haldar; Charles G Mullighan; Fenella Wojnarowska; Peter J Morris; Ken I Welsh
Glutathione S-transferase polymorphisms and skin cancer after renal transplantation.
Kidney international 2000;58(5):2186-93.
2000: J D Simmons; Charles G Mullighan; Ken I Welsh; Derek P Jewell
Vitamin D receptor gene polymorphism: association with Crohn's disease susceptibility.
Gut 2000;47(2):211-4.
2000: PJ Foley; Charles G Mullighan; Deirdre S McGrath; P Pantelidis; S Marshall; Penny Lympany; Kenneth I Welsh; Roland M Du Bois
Mannose-binding lectin promoter and structural gene variants in sarcoidosis.
European journal of clinical investigation 2000;30(6):549-52.
2000: Charles G Mullighan; Sara E Marshall; K I Welsh
Mannose binding lectin polymorphisms are associated with early age of disease onset and autoimmunity in common variable immunodeficiency.
Scandinavian journal of immunology 2000;51(2):111-22.
1999: Charles G Mullighan; Sara E Marshall; Mike Bunce; K I Welsh
Variation in immunoregulatory genes determines the clinical phenotype of common variable immunodeficiency.
Genes and immunity 1999;1(2):137-48.
1999: Andrew J McLaren; Sara E Marshall; Neil A Haldar; Charles G Mullighan; Susan V Fuggle; Peter J Morris; Ken I Welsh
Adhesion molecule polymorphisms in chronic renal allograft failure.
Kidney international 1999;55(5):1977-82.
1998: Penny Lympany; J J Avila; Charles G Mullighan; S Marshall; K I Welsh; R M du Bois
Rapid genotyping of transforming growth factor beta1 gene polymorphisms in a UK Caucasoid control population using the polymerase chain reaction and sequence-specific primers.
Tissue antigens 1998;52(6):573-8.
1998: W A C Sewell; Sara E Marshall; Charles G Mullighan; AG Bird
A hypogammaglobulinaemic man with respiratory failure.
Postgraduate medical journal 1998;74(874):503-4.
1998: Charles G Mullighan; Mike Bunce; GC Fanning; Sara E Marshall; KI Welsh
A rapid method of haplotyping HFE mutations and linkage disequilibrium in a Caucasoid population.
Gut 1998;42(4):566-9.
1998: Charles G Mullighan; Sara E Marshall; GC Fanning; D C Briggs; KI Welsh
Rapid haplotyping of mutations in the Duffy gene using the polymerase chain reaction and sequence-specific primers.
Tissue antigens 1998;51(2):195-9.
1997: Charles G Mullighan; GC Fanning; Helen Chapel; KI Welsh
TNF and lymphotoxin-alpha polymorphisms associated with common variable immunodeficiency: role in the pathogenesis of granulomatous disease.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):6236-41.
1997: Charles G Mullighan; Mike Bunce; Ken I Welsh
High-resolution HLA-DQB1 typing using the polymerase chain reaction and sequence-specific primers.
Tissue antigens 1997;50(6):688-92.
1997: W A Sewell; Charles G Mullighan; J Christie; Helen Chapel
Hepatitis C after intravenous immunoglobulin.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 1997;79(5):466-7.
1996: Charles G Mullighan; S J Read; A G Bird; J B Kurtz; Helen Chapel; K I Welsh
Human cytomegalovirus infection is not increased in common variable immunodeficiency.
Journal of clinical immunology 1996;16(5):272-7.