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Milan Holecek

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Miroslav Kovarik; Tomas Muthny; Ludek Sispera; Milan Holecek
The dose-dependent effects of endotoxin on protein metabolism in two types of rat skeletal muscle.
Milan Holecek
Muscle wasting in animal models of severe illness.
Milan Holecek; Miroslav Kovarik
Alterations in protein metabolism and amino acid concentrations in rats fed by a high-protein (casein-enriched) diet - effect of starvation.

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All Publications

2012: Miroslav Kovarik; Tomas Muthny; Ludek Sispera; Milan Holecek
The dose-dependent effects of endotoxin on protein metabolism in two types of rat skeletal muscle.
Journal of physiology and biochemistry 2012;68(3):385-95.
2012: Milan Holecek
Muscle wasting in animal models of severe illness.
International journal of experimental pathology 2012;93(3):157-71.
2011: Milan Holecek; Miroslav Kovarik
Alterations in protein metabolism and amino acid concentrations in rats fed by a high-protein (casein-enriched) diet - effect of starvation.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2011;49(12):3336-42.
2011: Milan Holecek; Roman Kandar; Ludek Sispera; Miroslav Kovarik
Acute hyperammonemia activates branched-chain amino acid catabolism and decreases their extracellular concentrations: different sensitivity of red and white muscle.
Amino acids 2011;40(2):575-84.
2010: Miroslav Kovarik; Tomas Muthny; Ludek Sispera; Milan Holecek
Effects of β-hydroxy-β-methylbutyrate treatment in different types of skeletal muscle of intact and septic rats.
Journal of physiology and biochemistry 2010;66(4):311-9.
2010: Milan Holecek
Three targets of branched-chain amino acid supplementation in the treatment of liver disease.
Nutrition (Burbank, Los Angeles County, Calif.) 2010;26(5):482-90.
2009: T Muthny; M Kovarik; Ludek Sispera; A de Meijere; O V Larionov; Ivan Tilser; Milan Holecek
The effect of new proteasome inhibitors, belactosin A and C, on protein metabolism in isolated rat skeletal muscle.
Journal of physiology and biochemistry 2009;65(2):137-46.
2009: Milan Holecek; T Muthny; M Kovarik; L Sispera
Effect of beta-hydroxy-beta-methylbutyrate (HMB) on protein metabolism in whole body and in selected tissues.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2009;47(1):255-9.
2008: Tomas Muthny; Miroslav Kovarik; Ludek Sispera; Ivan Tilser; Milan Holecek
Protein metabolism in slow- and fast-twitch skeletal muscle during turpentine-induced inflammation.
International journal of experimental pathology 2008;89(1):64-71.
2006: Milan Holecek; Tomas Muthny; Miroslav Kovarik; Ludek Sispera
Simultaneous infusion of glutamine and branched-chain amino acids (BCAA) to septic rats does not have more favorable effect on protein synthesis in muscle, liver, and small intestine than separate infusions.
JPEN. Journal of parenteral and enteral nutrition 2006;30(6):467-73.
2006: Roman Safránek; Nobuya Ishibashi; Youske Oka; Hiroyuki Ozasa; Kazuo Shirouzu; Milan Holecek
Modulation of inflammatory response in sepsis by proteasome inhibition.
International journal of experimental pathology 2006;87(5):369-72.
2006: Milan Holecek; Tomas Muthny; Miroslav Kovarik; Ludek Sispera
Proteasome inhibitor MG-132 enhances whole-body protein turnover in rat.
Biochemical and biophysical research communications 2006;345(1):38-42.
2006: Roman Safránek; Milan Holecek; Ludek Sispera; Tomás Muthný
Aspects of protein and amino acid metabolism in a model of severe glutamine deficiency in sepsis.
Annals of nutrition & metabolism 2006;50(4):361-7.
2005: Milan Holecek
[Glutamine and branched-chain amino acids--practical importance of their metabolic relations].
Casopís lékar̆ů c̆eských 2005;144 Suppl 3():9-12.
2005: Jana Kadlcíková; Milan Holecek; Roman Safránek; Ivan Tilser
Direct effects of proteasome inhibitor AdaAhx3L3VS on protein and amino acid metabolism in rat skeletal muscle.
Physiological research / Academia Scientiarum Bohemoslovaca 2005;54(5):541-7.
2004: Jana Kadlcíková; Milan Holecek; Roman Safránek; Ivan Tilser; Benedikt M Kessler
Effects of proteasome inhibitors MG132, ZL3VS and AdaAhx3L3VS on protein metabolism in septic rats.
International journal of experimental pathology 2004;85(6):365-71.
2004: Milan Holecek; Marcela Bielavská; Ludek Sprongl
Protein metabolism in guanethidine-treated rats.
International journal of experimental pathology 2004;85(5):257-64.
2003: Roman Safránek; Milan Holecek; Jana Kadlcíková; Ludek Sprongl; C Mislanová; Marián Kukan; J Chládek
Effect of acute acidosis on protein and amino acid metabolism in rats.
Clinical nutrition (Edinburgh, Scotland) 2003;22(5):437-43.
2003: Milan Holecek; Roman Safránek; Radana Rysavá; Jana Kadlcíková; Ludek Sprongl
Acute effects of acidosis on protein and amino acid metabolism in perfused rat liver.
International journal of experimental pathology 2003;84(4):185-90.
2003: Milan Holecek; Radana Rysava; Roman Safranek; Jana Kadlcikova; Ludek Sprongl
Acute effects of decreased glutamine supply on protein and amino acid metabolism in hepatic tissue: a study using isolated perfused rat liver.
Metabolism: clinical and experimental 2003;52(8):1062-7.
2003: Roman Safránek; Milan Holecek; Jana Kadlcíková; Jaromír Chládek; Csilla Mislanová; Marián Kukan
[Method of measurement of protein metabolism in isolated skeletal muscle of the rat].
Acta medica (Hradec Králové). Supplementum Universitas Carolina, Facultas Medica Hradec Králové 2003;46(1-2):33-7.
2002: Milan Holecek
Relation between glutamine, branched-chain amino acids, and protein metabolism.
Nutrition (Burbank, Los Angeles County, Calif.) 2002;18(2):130-3.
2002: Milan Holecek; Frantisek Skopec; Ludek Sprongl; J Mráz; H Skalská; Miroslav Pecka
Effect of alanyl-glutamine on leucine and protein metabolism in irradiated rats.
Amino acids 2002;22(1):95-108.
2001: Milan Holecek; Ludek Sprongl; Ivan Tilser; M Tichý
Leucine and protein metabolism in rats with chronic renal insufficiency.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2001;53(1):71-6.
2001: Milan Holecek; Ludek Sprongl; Ivan Tilser
Metabolism of branched-chain amino acids in starved rats: the role of hepatic tissue.
Physiological research / Academia Scientiarum Bohemoslovaca 2001;50(1):25-33.
2001: Milan Holecek
Effect of starvation on branched-chain alpha-keto acid dehydrogenase activity in rat heart and skeletal muscle.
Physiological research / Academia Scientiarum Bohemoslovaca 2001;50(1):19-24.
2001: Milan Holecek
The BCAA-BCKA cycle: its relation to alanine and glutamine synthesis and protein balance.
Nutrition (Burbank, Los Angeles County, Calif.) 2001;17(1):70.
2000: Milan Holecek; Ludek Sprongl; Ivan Tilser; M Tichý
Leucine and protein metabolism after bilateral nephrectomy in rats: the role of hepatic tissue.
Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie 2000;200(1):53-65.
2000: Milan Holecek; Frantisek Skopec; Ludek Sprongl
Influence of buthionine sulfoximine, S-adenosylmethionine and glutathione on liver regeneration following partial hepatectomy.
Arzneimittel-Forschung 2000;50(12):1093-8.
2000: Vladimír Teplan; Otto Schück; Miroslava Horácková; Jelena Skibová; Milan Holecek
Effect of a keto acid-amino acid supplement on the metabolism and renal elimination of branched-chain amino acids in patients with chronic renal insufficiency on a low protein diet.
Wiener klinische Wochenschrift 2000;112(20):876-81.
2000: Milan Holecek; Ludek Sprongl; M Tichý
Effect of hyperammonemia on leucine and protein metabolism in rats.
Metabolism: clinical and experimental 2000;49(10):1330-4.
2000: Milan Holecek; Frantisek Skopec; H Skalská; Ludek Sprongl
Effect of alanyl-glutamine on leucine and protein metabolism in endotoxemic rats.
JPEN. Journal of parenteral and enteral nutrition 2000;24(4):215-22.
1999: Milan Holecek
Nutritional modulation of liver regeneration by carbohydrates, lipids, and amino acids: a review.
Nutrition (Burbank, Los Angeles County, Calif.) 1999;15(10):784-8.
1999: Milan Holecek; H Skalská; J Mráz
Plasma amino acid levels after carbon tetrachloride induced acute liver damage. A dose-response and time-response study in rats.
Amino acids 1999;16(1):1-11.
1998: Milan Holecek; Ludek Sprongl; M Tichý; Miroslav Pecka
Leucine metabolism in rat liver after a bolus injection of endotoxin.
Metabolism: clinical and experimental 1998;47(6):681-5.
1997: Milan Holecek; Ludek Sprongl; Frantisek Skopec; C Andrýs; Miroslav Pecka
Leucine metabolism in TNF-alpha- and endotoxin-treated rats: contribution of hepatic tissue.
The American journal of physiology 1997;273(6 Pt 1):E1052-8.
1997: Milan Holecek; Ivan Tilser; Frantisek Skopec; Ludek Sprongl
Leucine metabolism in partially hepatectomized rats.
Journal of hepatology 1997;26(5):1141-7.
1996: Milan Holecek
Leucine metabolism in fasted and tumor necrosis factor-treated rats.
Clinical nutrition (Edinburgh, Scotland) 1996;15(2):91-3.
1996: Milan Holecek; I Tilser; Frantisek Skopec; Ludek Sprongl
Leucine metabolism in rats with cirrhosis.
Journal of hepatology 1996;24(2):209-16.
1995: Milan Holecek; Frantisek Skopec; Ludek Sprongl; Miroslav Pecka
Protein metabolism in specific tissues of endotoxin-treated rats: effect of nutritional status.
Physiological research / Academia Scientiarum Bohemoslovaca 1995;44(6):399-406.
1995: Milan Holecek; Frantisek Skopec; Ludek Sprongl
Protein metabolism in cirrhotic rats: effect of dietary restriction.
Annals of nutrition & metabolism 1995;39(6):346-54.
1994: Milan Holecek; J Mráz; M Tichý; Miroslav Pecka; Frantisek Skopec; I Hubácková; Romana Rysavá
Effects of essential phospholipids on the amino acid metabolism in whole body irradiated rats.
Arzneimittel-Forschung 1994;44(9):1054-9.
1992: Milan Holecek; J Mráz; P Koldová; Frantisek Skopec
Effect of polyunsaturated phosphatidylcholine on liver regeneration onset after hepatectomy in the rat.
Arzneimittel-Forschung 1992;42(3):337-9.
1991: Milan Holecek; J Simek; V Palicka; Zdenek Zadák
Effect of glucose and branched chain amino acid (BCAA) infusion on onset of liver regeneration and plasma amino acid pattern in partially hepatectomized rats.
Journal of hepatology 1991;13(1):14-20.
1989: J Simek; Z Cervinková; Milan Holecek
[The role of functional loading in liver regeneration mechanisms].
Ceskoslovenská fysiologie / Ústrední ústav biologický 1989;38(3):219-40.
1989: Milan Holecek; J Simek; Zdenek Zadák; Vladimír Bláha
Acceleration of the onset of liver regeneration by carnitine in partially hepatectomized rats.
Physiologia Bohemoslovaca 1989;38(6):503-8.
1989: Milan Holecek; J Simek
[Metabolic changes in liver tissue damage and the effect of nutrition on liver regeneration].
Sborník vědeckých prací Lékařské fakulty Karlovy univerzity v Hradci Králové. Supplementum 1989;32(1):5-40.
1988: Milan Holecek
[Perspectives in hepatocyte transplantation].
Casopís lékar̆ů c̆eských 1988;127(47):1445-7.
1988: G N Shorina; N P Bgatova; J Simek; Z Cervinková; Milan Holecek
[Effect of a food ration with a low-protein content on the processes of liver parenchyma recovery in rats after tetrachloromethane damage].
Biulleten' eksperimental'noĭ biologii i meditsiny 1988;105(3):336-8.
1988: Milan Holecek; J Simek
[Changes in energy metabolism in damaged liver tissue and possible effect of lipid and saccharide metabolism on liver regeneration].
Ceskoslovenská fysiologie / Ústrední ústav biologický 1988;37(2):145-62.
1988: Milan Holecek; J Simek
[Changes in the metabolism of amino acids in liver damage and the effect of amino acids on liver regeneration].
Ceskoslovenská fysiologie / Ústrední ústav biologický 1988;37(1):1-14.
1988: Milan Holecek; J Simek
Different effects of glucose and intralipid on the onset of liver regeneration in the early period after partial hepatectomy in the rat.
Experimental pathology 1988;33(4):257-60.
1988: J Holecková; Milan Holecek; J Simek
[Metabolic response in laboratory rats after 3 days and 14 days of the physical stress of swimming].
Ceskoslovenská fysiologie / Ústrední ústav biologický 1988;37(5):469-76.
1988: Milan Holecek; J Simek
Effect of the infusion of glucose, itralipid and nutramin on the initiation of rat liver regeneration after partial hepatectomy.
Physiologia Bohemoslovaca 1988;37(5):467-73.
1987: Milan Holecek; J Simek
[Saccharides and liver repair].
Sborník vědeckých prací Lékařské fakulty Karlovy univerzity v Hradci Králové. Supplementum 1987;30(3):367-96.
1987: J Simek; SN Kutina; D N Mayansky; H Vosvrdová; Z Cervinková; Milan Holecek
Role of the functional state of the liver RES in the pathogenesis of toxic liver injury.
Physiologia Bohemoslovaca 1987;36(5):435-40.
1987: Z Cervinková; N P Bgatova; T G Shorina; Milan Holecek; D Subrtová; H Vosvrdová; V A Shkurupy; J Simek
Structural and functional changes after the administration of tetrachlormethane in the liver of rats fed on diets with different protein contents.
Physiologia Bohemoslovaca 1987;36(4):349-59.
1986: J Simek; V I Shcherbakov; D N Mayansky; H Vosvrdová; Z Cervinková; Milan Holecek
Effect of the activation of macrophages on the course of regeneration of rat liver following partial hepatectomy.
Physiologia Bohemoslovaca 1986;35(5):473-80.
1986: J Simek; V A Shkurupy; G N Shorina; N P Bgatova; Z Cervinková; Milan Holecek
Effect of long-term administration of a high protein or low protein diet on rat liver. Morphological and biochemical findings.
Physiologia Bohemoslovaca 1986;35(2):127-33.
1985: Milan Holecek; J Simek
[Metabolism of branched amino acids in patients with an intact or damaged liver].
Ceskoslovenská fysiologie / Ústrední ústav biologický 1985;34(6):525-38.
1985: Milan Holecek; J Simek
Effect of glucose, fructose, sorbitol and amino acid solutions employed in clinical medicine on the development of liver regeneration after partial hepatectomy.
Physiologia Bohemoslovaca 1985;34(5):395-402.
1985: Milan Holecek; J Simek; M Kruf; Zdenek Zadák
Effect of branched chain amino acids on liver regeneration after partial hepatectomy.
Physiologia Bohemoslovaca 1985;34(4):359-66.
1983: Milan Holecek; J Simek; V Trojovská; I Egrtová
[The effect of saccharides on DNA synthesis in the intact and regenerating liver in rats refed after prior starvation].
Ceskoslovenská gastroenterologie a výz̆iva 1983;37(6-7):399-406.
1982: J Simek; Z Cervinková; J Smejkalová; Milan Holecek; V Trojovská; I Egrtová
[Dietary influence on the reparative activity of the liver in starving rats].
Bratislavské lekárske listy 1982;78(5):569-75.