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John Bradley Holcomb

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Phillip A Letourneau; Nena Matijevic; Madonna McManus; Shibani Pati; Kendell Sowards; Charles E Wade; Weiwei Wang; Yao-wei Wang; John Bradley Holcomb
Aged plasma transfusion increases mortality in a rat model of uncontrolled hemorrhage.
Daniel N Darlington; Angel V Delgado; Andrew P Cap; Chriselda G Fedyk; John Bradley Holcomb; Bijan S Kheirabadi; Anthony E Pusateri; Michael R Scherer; Charles E Wade; Michael A Dubick
Effect of hemodilution on coagulation and recombinant factor VIIa efficacy in human blood in vitro.
Bryan Cotton; Brijesh S Gill; Quinton M Hatch; Rosemary A Kozar; Eric LeFebvre; Michelle K McNutt; Neeti Reddy; Charles E Wade; Rondel Albarado; John Bradley Holcomb
Damage control resuscitation is associated with a reduction in resuscitation volumes and improvement in survival in 390 damage control laparotomy patients.

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2011: Phillip A Letourneau; Nena Matijevic; Madonna McManus; Shibani Pati; Kendell Sowards; Charles E Wade; Weiwei Wang; Yao-wei Wang; John Bradley Holcomb
Aged plasma transfusion increases mortality in a rat model of uncontrolled hemorrhage.
The Journal of trauma 2011;71(5):1115-9.
2011: Daniel N Darlington; Angel V Delgado; Andrew P Cap; Chriselda G Fedyk; John Bradley Holcomb; Bijan S Kheirabadi; Anthony E Pusateri; Michael R Scherer; Charles E Wade; Michael A Dubick
Effect of hemodilution on coagulation and recombinant factor VIIa efficacy in human blood in vitro.
The Journal of trauma 2011;71(5):1152-63.
2011: Bryan Cotton; Brijesh S Gill; Quinton M Hatch; Rosemary A Kozar; Eric LeFebvre; Michelle K McNutt; Neeti Reddy; Charles E Wade; Rondel Albarado; John Bradley Holcomb
Damage control resuscitation is associated with a reduction in resuscitation volumes and improvement in survival in 390 damage control laparotomy patients.
Annals of surgery 2011;254(4):598-605.
2011: Philip C Spinella; Neil Blumberg; Allan Doctor; John Bradley Holcomb
Does the storage duration of blood products affect outcomes in critically ill patients?
Transfusion 2011;51(8):1644-50.
2011: Bryan Cotton; Gabriel Faz; Quinton M Hatch; Rosemary A Kozar; Jeanette Podbielski; Zayde A Radwan; Charles Wade; John Bradley Holcomb
Rapid thrombelastography delivers real-time results that predict transfusion within 1 hour of admission.
The Journal of trauma 2011;71(2):407-14; discussion 414-7.
2011: Bryan Cotton; Lillian S Kao; Rosemary A Kozar; John Bradley Holcomb
Cost-utility analysis of levetiracetam and phenytoin for posttraumatic seizure prophylaxis.
The Journal of trauma 2011;71(2):375-9.
2011: Charles E Wade; C E Wade; M S Zenait; L Alarcon; G Beilman; K J Brasel; S Brundage; M Brunsvold; E M Bulger; M J Cohen; Stephen Cohn; Bryan Cotton; M A Croce; H M Cryer; M A De Moya; Deborah J del Junco; J C Duchesne; Richard P Dutton; E A Gonzalez; John R Hess; John Bradley Holcomb; J B Holcomb; R Ivatury; J Johannigman; P Knudson; R Kozar; J MacLeod; N E McSwain; J W Meredith; J E Mickalek; P Miller; J P Minei; P Muskat; L M Napolitano; T C Nunez; A B Peitzman; J F Pittet; G J Pomper; M A Schreiber; K C Sihler; J Sperry; Ronald M Stewart; B Tieu; A Tillou; G Vercruysse; B Marin
Variations between level I trauma centers in 24-hour mortality in severely injured patients requiring a massive transfusion.
The Journal of trauma 2011;71(2 Suppl 3):S389-93.
2011: Susan E Rowell; Martin A Schreiber; M A Schreiber; K C Sihler; J Sperry; Ronald M Stewart; B Tieu; A Tillou; G Vercruysse; C E Wade; M S Zenait; N E McSwain; J W Meredith; J E Mickalek; P Miller; J P Minei; P Muskat; L M Napolitano; T C Nunez; A B Peitzman; J F Pittet; J Pomper; L Alarcon; Ronald R Barbosa; G Beilman; K J Brasel; S Brundage; M Brunsvold; E M Bulger; M J Cohen; Stephen Cohn; Bryan Cotton; M A Croce; H M Cryer; M A De Moya; Brian Diggs; J C Duchesne; Richard P Dutton; E A Gonzalez; John R Hess; John Bradley Holcomb; R Ivatury; J Johannigamn; P Knudson; R Kozar; J MacLeod; B Marin
Specific abbreviated injury scale values are responsible for the underestimation of mortality in penetrating trauma patients by the injury severity score.
The Journal of trauma 2011;71(2 Suppl 3):S384-8.
2011: Susan E Rowell; Martin A Schreiber; M A Schreiber; K C Sihler; J Sperry; Ronald M Stewart; B Tieu; A Tillou; Philbert Y Van; G Vercruysse; C E Wade; M S Zenait; N E McSwain; J W Meredith; J E Mickalek; J P Minei; P Muskat; L M Napolitano; T C Nunez; A B Peitzman; J F Pittet; G J Pomper; P Pomper; L Alarcon; Carrie E Allison; Ronald R Barbosa; G Beilman; K J Brasel; S Brundage; M Brunsvold; E M Bulger; M J Cohen; Stephen Cohn; Bryan Cotton; M A Croce; H M Cryer; M A De Moya; J C Duchesne; Richard P Dutton; E A Gonzalez; John R Hess; John Bradley Holcomb; R Ivatury; J Johannigamn; P Knudson; R Kozar; J MacLeod; B Marin
Gender-based differences in mortality in response to high product ratio massive transfusion.
The Journal of trauma 2011;71(2 Suppl 3):S375-9.
2011: Ronald R Barbosa; G Beilman; K J Brasel; S Brundage; M Brunsvold; E M Bulger; M J Cohen; Stephen Cohn; Bryan Cotton; M A Croce; H M Cryer; M A De Moya; Brian Diggs; J C Duchesne; Richard P Dutton; E A Gonzalez; John R Hess; John Bradley Holcomb; R Ivatury; J Johannigamn; P Knudson; R Kozar; J MacLeod; N E McSwain; J W Meredith; J E Mickalek; J P Minei; P Muskat; L M Napolitano; T C Nunez; A B Peitzman; J F Pittet; G J Pomper; Susan E Rowell; Chitra N Sambasivan; Martin A Schreiber; M A Schreiber; K C Sihler; J Sperry; Philip C Spinella; Ronald M Stewart; B Tieu; A Tillou; G Vercruysse; C E Wade; M S Zenait; L Alarcon; B Marin
A predictive model for mortality in massively transfused trauma patients.
The Journal of trauma 2011;71(2 Suppl 3):S370-4.
2011: Ronald R Barbosa; G Beilman; K J Brasel; S Brundage; M Brunsvold; E M Bulger; M J Cohen; Stephen Cohn; Bryan Cotton; M A Croce; H M Cryer; M A De Moya; Brian Diggs; J C Duchesne; Richard P Dutton; E A Gonzalez; John R Hess; John Bradley Holcomb; R Ivatury; J Johannigamn; P Knudson; R Kozar; J MacLeod; N E McSwain; J W Meredith; J E Mickalek; P Miller; J P Minei; P Muskat; L M Napolitano; T C Nunez; A B Peitzman; J F Pittet; G J Pomper; Susan E Rowell; M A Schreiber; Martin A Schreiber; K C Sihler; J Sperry; Ronald M Stewart; B Tieu; A Tillou; G Vercruysse; C E Wade; M S Zenait; L Alarcon; B Marin
Profoundly abnormal initial physiologic and biochemical data cannot be used to determine futility in massively transfused trauma patients.
The Journal of trauma 2011;71(2 Suppl 3):S364-9.
2011: Lisa M Brown; S Brundage; M Brunsvold; E M Bulger; Mitchell J Cohen; Stephen Cohn; Bryan Cotton; M A Croce; H M Cryer; M A De Moya; J C Duchesne; Richard P Dutton; E A Gonzalez; John R Hess; John Bradley Holcomb; R Ivatury; J Johannigamn; P Knudson; R Kozar; J MacLeod; N E McSwain; J W Meredith; J E Mickalek; P Miller; J P Minei; P Muskat; L M Napolitano; T C Nunez; A B Peitzman; J F Pittet; G J Pomper; M A Schreiber; K C Sihler; J Sperry; Ronald M Stewart; B Tieu; A Tillou; G Vercruysse; C E Wade; M S Zenait; L Alarcon; Seppo O Aro; G Beilman; K J Brasel; B Marin
A high fresh frozen plasma: packed red blood cell transfusion ratio decreases mortality in all massively transfused trauma patients regardless of admission international normalized ratio.
The Journal of trauma 2011;71(2 Suppl 3):S358-63.
2011: Susan E Rowell; Martin A Schreiber; M A Schreiber; K C Sihler; J Sperry; Ronald M Stewart; B Tieu; A Tillou; G Vercruysse; C E Wade; M S Zenait; N E McSwain; J W Meredith; J E Mickalek; P Miller; J P Minei; P Muskat; L M Napolitano; T C Nunez; A B Peitzman; J F Pittet; G J Pomper; L Alarcon; Ronald R Barbosa; G Beilman; K J Brasel; S Brundage; M Brunsvold; E M Bulger; M J Cohen; Stephen Cohn; Bryan Cotton; M A Croce; H M Cryer; M A De Moya; Brian Diggs; J C Duchesne; Richard P Dutton; E A Gonzalez; John R Hess; John Bradley Holcomb; R Ivatury; J Johannigamn; P Knudson; R Kozar; J MacLeod; B Marin
Effect of high product ratio massive transfusion on mortality in blunt and penetrating trauma patients.
The Journal of trauma 2011;71(2 Suppl 3):S353-7.
2011: K J Brasel; K J Brasel; S Brundage; M Brunsvold; E M Bulger; Stephen Cohn; Bryan Cotton; M A Croce; H M Cryer; H M Cryer; M A De Moya; Fei Du; J C Duchesne; Richard P Dutton; Ernest A Gonzalez; John R Hess; John Bradley Holcomb; R Ivatury; Kenneth M Jastrow; J Johannigamn; P Knudson; Rosemary Kozar; J MacLeod; Marc Maegele; N E McSwain; J W Meredith; J E Mickalek; P Miller; J P Minei; P Muskat; L M Napolitano; T C Nunez; A B Peitzman; Jeremy G Perkins; J F Pittet; G J Pomper; Martin Schreiber; K C Sihler; J Sperry; Philip C Spinella; Ronald M Stewart; B Tieu; G Vercruysse; G Vercruysse; Charles E Wade; Lee A Zarzabal; M S Zenait; L Alarcon; G Beilman; Lorne H Blackbourne; Matthew A Borgman; B Marin
The association of blood component use ratios with the survival of massively transfused trauma patients with and without severe brain injury.
The Journal of trauma 2011;71(2 Suppl 3):S343-52.
2011: Lisa M Brown; S Brundage; M Brunsvold; M Brunsvold; E M Bulger; Mariah S Call; Mitchell J Cohen; Stephen Cohn; Bryan Cotton; M A Croce; H M Cryer; M A De Moya; J C Duchesne; Richard P Dutton; E A Gonzalez; John R Hess; John Bradley Holcomb; R Ivatury; J Johannigamn; R Kozar; J MacLeod; M Margaret Knudson; N E McSwain; J W Meredith; J E Mickalek; P Miller; J P Minei; P Muskat; L M Napolitano; T C Nunez; A B Peitzman; J F Pittet; G J Pomper; M A Schreiber; J Sperry; Ronald M Stewart; B Tieu; A Tillou; G Vercruysse; C E Wade; M S Zenait; L Alarcon; G Beilman; K J Brasel; B Marin
A normal platelet count may not be enough: the impact of admission platelet count on mortality and transfusion in severely injured trauma patients.
The Journal of trauma 2011;71(2 Suppl 3):S337-42.
2011: Chitra N Sambasivan; Martin A Schreiber; K C Sihler; J Sperry; Ronald M Stewart; B Tieu; A Tillou; G Vercruysse; C E Wade; M S Zenait; Karen A Zink; N E McSwain; J W Meredith; Joel Michalek; P Miller; J P Minei; P Muskat; Prakash V Nair; L M Napolitano; T C Nunez; A B Peitzman; J F Pittet; G J Pomper; L Alarcon; G Beilman; K J Brasel; S Brundage; M Brunsvold; E M Bulger; M J Cohen; Stephen Cohn; Bryan Cotton; M A Croce; H M Cryer; M A De Moya; J C Duchesne; Richard P Dutton; E A Gonzalez; John R Hess; John Bradley Holcomb; R Ivatury; J Johannigamn; P Knudson; R Kozar; Nicholas R Kunio; J MacLeod; B Marin
High ratios of plasma and platelets to packed red blood cells do not affect mortality in nonmassively transfused patients.
The Journal of trauma 2011;71(2 Suppl 3):S329-36.
2011: John B Holcomb; R R Ivatury; J A Johannigamn; P Knudson; Rosemary A Kozar; R A Kozar; J B MacLeod; L H Alarcon; G J Beilman; K J Brasel; S I Brundage; M E Brunsvold; E M Bulger; M J Cohen; Stephen Cohn; Bryan Cotton; M A Croce; H M Cryer; M A DeMoya; Jing-Fei Dong; J C Duchesne; Richard P Dutton; John R Hess; John Bradley Holcomb; Nena Matijevic; N E McSwain; J W Meredith; J E Michalek; Joel Michalek; P R Miller; J P Minei; P C Muskat; L M Napolitano; T C Nunez; Shibani Pati; A B Peitzman; Jeremy G Perkins; J F Pittet; G J Pomper; M A Schreiber; K C Sihler; J L Sperry; Phillip C Spinella; R M Steward; B H Tieu; A Tillou; G A Vercruysse; Charles E Wade; C E Wade; Lee A Zarzabal; M S Zenati; B Marin
Increased platelet:RBC ratios are associated with improved survival after massive transfusion.
The Journal of trauma 2011;71(2 Suppl 3):S318-28.
2011: John Bradley Holcomb; R Ivatury; J Johannigamn; P Knudson; R Kozar; J MacLeod; L Alarcon; G Beilman; K J Brasel; S Brundage; M Brunsvold; E M Bulger; M J Cohen; Stephen Cohn; Bryan Cotton; M A Croce; H M Cryer; M A De Moya; J C Duchesne; Richard P Dutton; E A Gonzalez; John R Hess; N E McSwain; J W Meredith; J E Mickalek; P Miller; J P Minei; P Muskat; L M Napolitano; T C Nunez; A B Peitzman; J F Pittet; G J Pomper; M A Schreiber; K C Sihler; J Sperry; Ronald M Stewart; B Tieu; A Tillou; G Vercruysse; Charles E Wade; M S Zenait; B Marin
Defining present blood component transfusion practices in trauma patients: papers from the Trauma Outcomes Group.
The Journal of trauma 2011;71(2 Suppl 3):S315-7.
2011: Duane R Hospenthal; Joseph R Hsu; Kent E Kester; Gregory J Martin; Leon E Moores; Clinton K Murray; William T Obremskey; Kyle Petersen; Evan M Renz; Jeffrey R Saffle; Joseph S Solomkin; Deena E Sutter; David R Tribble; Joseph C Wenke; Timothy J Whitman; Andrew R Wiesen; Glenn W Wortmann; Romney C Andersen; R Bryan Bell; Jason H Calhoun; Leopoldo C Cancio; John M Cho; Kevin K Chung; Jon C Clasper; Marcus H Colyer; Nicholas G Conger; George P Costanzo; Helen K Crouch; Thomas K Curry; Laurie C D'Avignon; Warren C Dorlac; James R Dunne; Brian J Eastridge; James R Ficke; Mark E Fleming; Michael A Forgione; Andrew D Green; Robert G Hale; David K Hayes; John Bradley Holcomb
Guidelines for the prevention of infections associated with combat-related injuries: 2011 update: endorsed by the Infectious Diseases Society of America and the Surgical Infection Society.
The Journal of trauma 2011;71(2 Suppl 2):S210-34.
2011: Duane R Hospenthal; Joseph R Hsu; Kent E Kester; Gregory J Martin; Leon E Moores; Clinton K Murray; William T Obremskey; Kyle Petersen; Evan M Renz; Jeffrey R Saffle; Joseph S Solomkin; Deena E Sutter; David R Tribble; Joseph C Wenke; Timothy J Whitman; Andrew R Wiesen; Glenn W Wortmann; Romney C Andersen; R Bryan Bell; Jason H Calhoun; Leopoldo C Cancio; John M Cho; Kevin K Chung; Jon C Clasper; Marcus H Colyer; Nicholas G Conger; George P Costanzo; Helen K Crouch; Thomas K Curry; Laurie C D'Avignon; Warren C Dorlac; James R Dunne; Brian J Eastridge; James R Ficke; Mark E Fleming; Michael A Forgione; Andrew D Green; Robert G Hale; David K Hayes; John Bradley Holcomb
Executive summary: Guidelines for the prevention of infections associated with combat-related injuries: 2011 update: endorsed by the Infectious Diseases Society of America and the Surgical Infection Society.
The Journal of trauma 2011;71(2 Suppl 2):S202-9.
2011: John Bradley Holcomb
A novel and potentially unifying mechanism for shock induced early coagulopathy.
Annals of surgery 2011;254(2):201-2.
2011: John W Simmons; Christopher E White; Brian J Eastridge; John Bradley Holcomb; James E Mace; Jeremy G Perkins; Lorne H Blackbourne
Impact of improved combat casualty care on combat wounded undergoing exploratory laparotomy and massive transfusion.
The Journal of trauma 2011;71(1 Suppl):S82-6.
2011: Richard P Dutton; Carl J Hauser; John Bradley Holcomb; Ari Leppaniemi; Michael Parr; Bartholomew J Tortella; Jean-Louis Vincent; Gordon R Bernard; Kenneth D Boffard; Bertil Bouillon; Howard R Champion; Martin A Croce; Jeannett Dimsits
Recombinant activated factor VII safety in trauma patients: results from the CONTROL trial.
The Journal of trauma 2011;71(1):12-9.
2011: M A Borgman; B Bouillon; John Bradley Holcomb; R Lefering; P C Spinella; C E Wade; L H Blackbourne; Marc Maegele
The effect of FFP:RBC ratio on morbidity and mortality in trauma patients based on transfusion prediction score.
Vox sanguinis 2011;101(1):44-54.
2011: Nena Matijevic; Yao-Wei W Wang; Vadim Kostousov; Charles E Wade; K Vinod Vijayan; John Bradley Holcomb
Decline in platelet microparticles contributes to reduced hemostatic potential of stored plasma.
Thrombosis research 2011;128(1):35-41.
2011: Chaojun Duan; Ernest A Gonzalez; John Bradley Holcomb; Rosemary A Kozar; Xianghua Liu; Shibani Pati; Charles E Wade; Weiwei Wang; Wenli Yang; Yanna Cao; Zhuchu Chen; Xiyun Deng; Tien C Ko
Increased transforming growth factor β contributes to deterioration of refrigerated fresh frozen plasma's effects in vitro on endothelial cells.
Shock (Augusta, Ga.) 2011;36(1):54-9.
2011: Quinton M Hatch; John Bradley Holcomb; Rosemary A Kozar; Lisa M Osterhout; Jeanette Podbielski; Charles E Wade; Asma Ashraf; Bryan Cotton
Current use of damage-control laparotomy, closure rates, and predictors of early fascial closure at the first take-back.
The Journal of trauma 2011;70(6):1429-36.
2011: Rosemary A Kozar; Zhanglong Peng; Rongzhen Zhang; John Bradley Holcomb; Shibani Pati; Pyong Park; Tien C Ko; Angel Paredes
Plasma restoration of endothelial glycocalyx in a rodent model of hemorrhagic shock.
Anesthesia and analgesia 2011;112(6):1289-95.
2011: John Bradley Holcomb
Reconstitution: reverse engineering.
The Journal of trauma 2011;70(5 Suppl):S65-7.
2011: Norman E McSwain; Todd E Rasmussen; Robert R Roussel; Martin A Schreiber; Steven R Shackford; Charles E Wade; Kenneth G Proctor; Frank K Butler; Howard R Champion; Brian J Eastridge; Timothy C Fabian; John Bradley Holcomb; David B Hoyt; Lorne H Blackbourne
State of the art of fluid resuscitation 2010: prehospital and immediate transition to the hospital.
The Journal of trauma 2011;70(5 Suppl):S2-10.
2011: Shibani Pati; John R Salsbury; Charles E Wade; Peter A Walker; Kathryn A Wataha; Jing Zhao; Yuhai Zhao; Lisa A Baer; John Adam Baumgartner; Charles S Cox; Pramod K Dash; Marie-Francoise Doursout; Michael H Gerber; Maria P Huby; Rosemary A Kozar; Phillip A Letourneau; Tyler D Menge; John Bradley Holcomb
Bone marrow derived mesenchymal stem cells inhibit inflammation and preserve vascular endothelial integrity in the lungs after hemorrhagic shock.
PloS one 2011;6(9):e25171.
2011: Ricky J Haywood-Watson; John Bradley Holcomb; Ernest A Gonzalez; Tyler Menge; Pyong Woo Park; Shibani Pati; Zhanglong Peng; WeiWei Wang; Ana Maria Zaske; Rosemary A Kozar
Modulation of syndecan-1 shedding after hemorrhagic shock and resuscitation.
PloS one 2011;6(8):e23530.
2011: Charles E Wade; Brian J Eastridge; John G McManus; José Salinas; John Bradley Holcomb
Admission hypo- or hyperthermia and survival after trauma in civilian and military environments.
International journal of emergency medicine 2011;4(1):35.
1988: M E Morison; John Bradley Holcomb
The MCV Crown-Down Technique: a modified alternative coronal-flaring approach for endodontics.
Virginia dental journal 1988;65(3):32-8.