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Sjoerd van der burg

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Eveline M Dijkgraaf; Renske Goedemans; Moniek Heusinkveld; Veena Jha; Judith R Kroep; Johan W R Nortier; Bart Tummers; Lisa T C Vogelpoel; Marij J P Welters; Sjoerd H van der burg
Chemotherapy alters monocyte differentiation to favor generation of cancer-supporting m2 macrophages in the tumor microenvironment.
Dinja Oosterhoff; Sjoerd H van der burg; Thomas van Es; Yvette van Kooyk; Moniek Heusinkveld; Ilona Kosten; Malin Lindstedt; Sinéad M Lougheed; Sven C M Bruijns; Tanja D de Gruijl
Intradermal delivery of TLR agonists in a human explant skin model: preferential activation of migratory dendritic cells by polyribosinic-polyribocytidylic acid and peptidoglycans.
Helene Filbert; Cécile Gouttefangeas; Sylvia Janetzki; Christian H Ottensmeier; Bernhard Y Renard; Ugur Sahin; Sjoerd H van der burg; Marij J P Welters; Sebastian Attig; Nicole Bidmon; Cedrik Michael Britten
Serum-free freezing media support high cell quality and excellent ELISPOT assay performance across a wide variety of different assay protocols.

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2013: Eveline M Dijkgraaf; Renske Goedemans; Moniek Heusinkveld; Veena Jha; Judith R Kroep; Johan W R Nortier; Bart Tummers; Lisa T C Vogelpoel; Marij J P Welters; Sjoerd H van der burg
Chemotherapy alters monocyte differentiation to favor generation of cancer-supporting m2 macrophages in the tumor microenvironment.
Cancer research 2013;73(8):2480-92.
2013: Dinja Oosterhoff; Sjoerd H van der burg; Thomas van Es; Yvette van Kooyk; Moniek Heusinkveld; Ilona Kosten; Malin Lindstedt; Sinéad M Lougheed; Sven C M Bruijns; Tanja D de Gruijl
Intradermal delivery of TLR agonists in a human explant skin model: preferential activation of migratory dendritic cells by polyribosinic-polyribocytidylic acid and peptidoglycans.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(7):3338-45.
2013: Helene Filbert; Cécile Gouttefangeas; Sylvia Janetzki; Christian H Ottensmeier; Bernhard Y Renard; Ugur Sahin; Sjoerd H van der burg; Marij J P Welters; Sebastian Attig; Nicole Bidmon; Cedrik Michael Britten
Serum-free freezing media support high cell quality and excellent ELISPOT assay performance across a wide variety of different assay protocols.
Cancer immunology, immunotherapy : CII 2013;62(4):615-27.
2013: Eliane C M Zeestraten; Jan Wouter Drijfhout; Lorraine M Fathers; Hans Gelderblom; Rogier Jongen; Ellen Kapiteijn; Peter Kuppen; Hans W Nijman; Jaap Oostendorp; Sepideh Saadatmand; Frank M Speetjens; Linda F M Stynenbosch; Rob Valentijn; Cornelis J H van de Velde; Sjoerd H van der burg; Marij J P Welters; Cornelis J M Melief
Addition of interferon-α to the p53-SLP® vaccine results in increased production of interferon-γ in vaccinated colorectal cancer patients: a phase I/II clinical trial.
International journal of cancer. Journal international du cancer 2013;132(7):1581-91.
2013: Satwinder Kaur Singh; Bart Tummers; Els Verdegaal; Marij J P Welters; Cedrik Michael Britten; Kees L M C Franken; Raquel Gomez; Cécile Gouttefangeas; Karoline Laske; Christian H Ottensmeier; Ton N Schumacher; Sjoerd H van der burg
The development of standard samples with a defined number of antigen-specific T cells to harmonize T cell assays: a proof-of-principle study.
Cancer immunology, immunotherapy : CII 2013;62(3):489-501.
2013: Mariëtte I E Van Poelgeest; Marij J P Welters; Edith M G van Esch; EL van Persijn van Meerten; Dorien M A Berends-van der Meer; Lorraine M Fathers; Gert Jan Fleuren; Gemma G Kenter; Gijs Kerpershoek; Margriet J G Löwik; Cornelis J M Melief; Jaap Oostendorp; Linda F M Stynenbosch; Rob Valentijn; Muriel van den Hende; Sjoerd H van der burg
HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial.
Journal of translational medicine 2013;11():88.
2013: Long V Ly; Marjolein Sluijter; Sjoerd H van der burg; Martine J Jager; Thorbald van Hall
Effective cooperation of monoclonal antibody and peptide vaccine for the treatment of mouse melanoma.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(1):489-96.
2013: Margit H Lampen; Marjolein Sluijter; Jennifer M Tjon; Sjoerd H van der burg; Arnoud de Ru; Karin Dijkman; Annemieke Geluk; Chopie Hassan; Peter van Veelen; Thorbald van Hall
Alternative peptide repertoire of HLA-E reveals a binding motif that is strikingly similar to HLA-A2.
Molecular immunology 2013;53(1-2):126-31.
2012: Peter L Stern; Sjoerd H van der burg; Thomas R Broker; Alison Fiander; Ian N Hampson; Henry C Kitchener; Charles J Lacey; Mark H Einstein
Therapy of human papillomavirus-related disease.
Vaccine 2012;30 Suppl 5():F71-82.
2012: Satwinder Kaur Singh; Linda F M Stynenbosch; Marij J P Welters; Peter J K Kuppen; Cornelis J M Melief; Maaike Meyering; Tamara H Ramwadhdoebe; Anke Redeker; Sjoerd H van der burg
The simultaneous ex vivo detection of low-frequency antigen-specific CD4+ and CD8+ T-cell responses using overlapping peptide pools.
Cancer immunology, immunotherapy : CII 2012;61(11):1953-63.
2012: Peggy J de Vos van Steenwijk; Lorraine M Fathers; Gert Jan Fleuren; Bart W J Hellebrekers; Gemma G Kenter; Margriet J G Löwik; Cornelis J M Melief; Jaap Oostendorp; Tamara H Ramwadhdoebe; Rob Valentijn; Caroline E van der Minne; Mariëtte I E Van Poelgeest; Marij J P Welters; Dorien M A Berends-van der Meer; Sjoerd H van der burg
A placebo-controlled randomized HPV16 synthetic long-peptide vaccination study in women with high-grade cervical squamous intraepithelial lesions.
Cancer immunology, immunotherapy : CII 2012;61(9):1485-92.
2012: Renee Vermeij; Rinze Wolf; Jaap Oostendorp; Anna K L Reyners; Sjoerd H van der burg; Ate G J van der Zee; Joost Bart; Toos Daemen; Jan Wouter Drijfhout; Ineke L E Hamming; Harry Hollema; Baukje Nynke Hoogeboom; Ninke Leffers; Cornelis J Melief; Barbara H W Molmans; Hans W Nijman
Potentiation of a p53-SLP vaccine by cyclophosphamide in ovarian cancer: a single-arm phase II study.
International journal of cancer. Journal international du cancer 2012;131(5):E670-80.
2012: Cedrik Michael Britten; L H Butterfield; G Ferrari; Cécile Gouttefangeas; A Hoos; C Huber; Sylvia Janetzki; Michael Kalos; Hyam I Levitsky; Holden T Maecker; C J M Melief; J O'Donnell-Tormey; Kunle Odunsi; L J Old; T H M Ottenhoff; C Ottensmeier; G Pawelec; M Roederer; B O Roep; P Romero; Sjoerd H van der burg; S Walter; M M Davis
T cell assays and MIATA: the essential minimum for maximum impact.
Immunity 2012;37(1):1-2.
2012: M Heusinkveld; J C Jansen; A P M Langeveld; J W R Nortier; V T H B M Smit; R J P Briet; Hans Gelderblom; R Goedemans; A Gorter; Sjoerd H van der burg
Systemic and local human papillomavirus 16-specific T-cell immunity in patients with head and neck cancer.
International journal of cancer. Journal international du cancer 2012;131(2):E74-85.
2012: Edith M G van Esch; Ekaterina S. Jordanova; J Baptist M Z Trimbos; Sjoerd H van der burg; Marij J P Welters; Mariëtte I E van Poelgeest
Treatment failure in patients with HPV 16-induced vulvar intraepithelial neoplasia: understanding different clinical responses to immunotherapy.
Expert review of vaccines 2012;11(7):821-40.
2012: Marij J P Welters; Cedrik Michael Britten; Cécile Gouttefangeas; Anne Letsch; Christian H Ottensmeier; Tamara H Ramwadhdoebe; Sjoerd H van der burg
Harmonization of the intracellular cytokine staining assay.
Cancer immunology, immunotherapy : CII 2012;61(7):967-78.
2012: M Schrevel; Natalja T Ter Haar; J B M Z Trimbos; Sjoerd H van der burg; Gert Jan Fleuren; Arko Gorter; R Karim; Ekaterina S. Jordanova
CXCR7 expression is associated with disease-free and disease-specific survival in cervical cancer patients.
British journal of cancer 2012;106(9):1520-5.
2012: Sjoerd H van der burg
Immunotherapy of human papilloma virus induced disease.
The open virology journal 2012;6():257-63.
2012: Eveline M Dijkgraaf; Johan W R Nortier; Sjoerd H van der burg; Marij J P Welters; Judith R Kroep
Interleukin-6/interleukin-6 receptor pathway as a new therapy target in epithelial ovarian cancer.
Current pharmaceutical design 2012;18(25):3816-27.
2012: Thorbald van Hall; Sjoerd H van der burg
Mechanisms of peptide vaccination in mouse models: tolerance, immunity, and hyperreactivity.
Advances in immunology 2012;114():51-76.
2012: Ninke Leffers; Kees J Melief; Toos Daemen; Ineke E Hamming; Baukje Nynke Hoogeboom; Ute R Schulze; Sjoerd H van der burg; Ate G J van der Zee; Renee Vermeij; Rinze Wolf; Hans W Nijman
Long-term clinical and immunological effects of p53-SLP® vaccine in patients with ovarian cancer.
International journal of cancer. Journal international du cancer 2012;130(1):105-12.
2011: Sjoerd H van der burg; Marij J P Welters; Cedrik Michael Britten; Cécile Gouttefangeas; Sylvia Janetzki; Michael Kalos; Christian Ottensmeier; Pedro Romero; Axel Hoos
Harmonization of immune biomarker assays for clinical studies.
Science translational medicine 2011;3(108):108ps44.
2011: Cláudia C Oliveira; Bianca Querido; Marjolein Sluijter; Sjoerd H van der burg; Jens Derbinski; Thorbald van Hall
Peptide transporter TAP mediates between competing antigen sources generating distinct surface MHC class I peptide repertoires.
European journal of immunology 2011;41(11):3114-24.
2011: jan pander; Sjoerd H van der burg; Tahar van der Straaten; Renée Baak-Pablo; Hans Gelderblom; Henk-Jan Guchelaar; Moniek Heusinkveld; Ekaterina S. Jordanova; Hans Morreau; Thorbald van Hall
Activation of tumor-promoting type 2 macrophages by EGFR-targeting antibody cetuximab.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(17):5668-73.
2011: Moniek Heusinkveld; Tamara H Ramwadhdoebe; Peggy J de Vos van Steenwijk; Renske Goedemans; Arko Gorter; Thorbald van Hall; Marij J P Welters; Sjoerd H van der burg
M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(3):1157-65.
2011: Renee Vermeij; Toos Daemen; Geertruida H de Bock; Harry Hollema; Ninke Leffers; Ute Schulze; Klaske A ten Hoor; Sjoerd H van der burg; Ate G J van der Zee; Hans W Nijman
Tumor-infiltrating cytotoxic T lymphocytes as independent prognostic factor in epithelial ovarian cancer with wilms tumor protein 1 overexpression.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2011;34(6):516-23.
2011: Els Verdegaal; Marten Visser; John B A G Haanen; Ellen Kapiteijn; Johan W R Nortier; Tamara H Ramwadhdoebé; Sjoerd H van der burg; Caroline E van der Minne; Jeanne A Q M J van Steijn; Susanne Osanto
Successful treatment of metastatic melanoma by adoptive transfer of blood-derived polyclonal tumor-specific CD4+ and CD8+ T cells in combination with low-dose interferon-alpha.
Cancer immunology, immunotherapy : CII 2011;60(7):953-63.
2011: Marloes Gooden; Ekaterina S. Jordanova; Margit Lampen; Ninke Leffers; Hans Nijman; J Baptist Trimbos; Sjoerd H van der burg; Thorbald van Hall
HLA-E expression by gynecological cancers restrains tumor-infiltrating CD8⁺ T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(26):10656-61.
2011: Frank M Speetjens; Peter J K Kuppen; Cornelis J M Melief; Eliane C M Zeestraten; Sjoerd H van der burg
Colorectal cancer vaccines in clinical trials.
Expert review of vaccines 2011;10(6):899-921.
2011: Lisa H Butterfield; Madhav V Dhodapkar; Cedrik M Britten; Bernard A Fox; Leif Håkansson; Sylvia Janetzki; Yutaka Kawakami; Samir Khleif; Thomas-Oliver Kleen; Peter P Lee; Cristina Maccalli; Holden T Maecker; Vernon C Maino; Michele Maio; Anatoli Malyguine; Francesco Marincola; Giuseppe Masucci; A Karolina Palucka; Graham Pawelec; Douglas M Potter; Licia Rivoltini; Lupe G Salazar; Dolores J Schendel; Craig L Slingluff; Wenru Song; David F Stroncek; Hideaki Tahara; Magdalena Thurin; Giorgio Trinchieri; Sjoerd H van der burg; Theresa L Whiteside; JON WIGGINTON; Mary L Disis
Recommendations from the iSBTc-SITC/FDA/NCI Workshop on Immunotherapy Biomarkers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(10):3064-76.
2011: Sjoerd H van der burg; Cornelis J M Melief
Therapeutic vaccination against human papilloma virus induced malignancies.
Current opinion in immunology 2011;23(2):252-7.
2011: Sjoerd H van der burg; Ramon Arens; Cornelis J M Melief
Immunotherapy for persistent viral infections and associated disease.
Trends in immunology 2011;32(3):97-103.
2011: Moniek Heusinkveld; Marij J P Welters; Mariëtte I E Van Poelgeest; Jeanette M van der Hulst; Cornelis J M Melief; Gert Jan J Fleuren; Gemma G Kenter; Sjoerd H van der burg
The detection of circulating human papillomavirus-specific T cells is associated with improved survival of patients with deeply infiltrating tumors.
International journal of cancer. Journal international du cancer 2011;128(2):379-89.
2011: Moniek Heusinkveld; Sjoerd H van der burg
Identification and manipulation of tumor associated macrophages in human cancers.
Journal of translational medicine 2011;9():216.
2011: Bernard A Fox; Thomas F Gajewski; Jerome Galon; Jared A Gollob; Cécile Gouttefangeas; Fabio Grizzi; Michele Guida; Leif Håkansson; Kristen Hege; Ronald B Herberman; F Stephen Hodi; Axel Hoos; Christoph Huber; Patrick Hwu; Kohzoh Imai; Elizabeth M Jaffee; Sylvia Janetzki; Carl H June; Pawel Kalinski; Howard L Kaufman; Koji Kawakami; Yutaka Kawakami; Ulrich Keilholtz; Samir N Khleif; Rolf Kiessling; Beatrix Kotlan; Guido Kroemer; Rejean Lapointe; Hyam I Levitsky; Michael T Lotze; Cristina Maccalli; Michele Maio; Francesco M Marincola; Jens-Peter Marschner; Michael J Mastrangelo; Giuseppe Masucci; Ignacio Melero; Cornelius Melief; William Murphy; Brad Nelson; Andrea Nicolini; Michael I Nishimura; Jill O'Donnell-Tormey; Kunle Odunsi; Pamela S Ohashi; Lloyd J Old; Christian Ottensmeier; Michael Papamichail; Giorgio Parmiani; Graham Pawelec; Enrico Proietti; Shukui Qin; Robert Rees; Antoni Ribas; Ruggero Ridolfi; Gerd Ritter; Licia Rivoltini; Pedro J Romero; Mohamed L Salem; Dolores J Schendel; Rik J Scheper; Barbara Seliger; Padmanee Sharma; Hiroshi Shiku; Harpreet Singh-Jasuja; Wenru Song; Per Thor Straten; Hideaki Tahara; Zhigang Tian; Sjoerd H van der burg; Paul von Hoegen; Ena Wang; Marij Jp Welters; JON WIGGINTON; Hauke Winter; Tara Withington; Jedd D Wolchok; Weihua Xiao; Laurence Zitvogel; Heinz Zwierzina; Steinar Aamdal; James P Allison; Paolo Antonio Ascierto; Michael B Atkins; Jirina Bartunkova; Lothar Bergmann; Neil Berinstein; Cristina C Bonorino; Ernest Borden; Jonathan L Bramson; Cedrik M Britten; Lisa H Butterfield; Xuetao Cao; William E Carson; Alfred E Chang; Dainius Characiejus; A Raja Choudhury; George Coukos; Tanja de Gruijl; Robert O Dillman; Harry Dolstra; Glenn Dranoff; Lindy G Durrant; James H Finke; Mary L Disis
Defining the critical hurdles in cancer immunotherapy.
Journal of translational medicine 2011;9(1):214.
2011: Kirsten B J Scholten; Annelies W Turksma; Muriel van den Hende; Sjoerd H van der burg; Mirjam H M Heemskerk; Chris J L M Meijer; Janneke J Ruizendaal; Erik Hooijberg
Generating HPV specific T helper cells for the treatment of HPV induced malignancies using TCR gene transfer.
Journal of translational medicine 2011;9():147.
2011: R Vermeij; N Leffers; Sjoerd H van der burg; C J Melief; Toos Daemen; H W Nijman
Immunological and clinical effects of vaccines targeting p53-overexpressing malignancies.
Journal of biomedicine & biotechnology 2011;2011():702146.
2011: Rezaul Karim; Craig Meyers; Claude Backendorf; Kristina Ludigs; Rienk Offringa; Gert-Jan B van Ommen; Cornelis J M Melief; Sjoerd H van der burg; Judith M Boer
Human papillomavirus deregulates the response of a cellular network comprising of chemotactic and proinflammatory genes.
PloS one 2011;6(3):e17848.
2011: Cedrik Michael Britten; S Janetzki; Sjoerd H van der burg; Christoph Huber; M Kalos; Hyam I Levitsky; Holden T Maecker; C J M Melief; J O'Donnell-Tormey; K Odunsi; L J Old; Graham Pawelec; B O Roep; P Romero; A Hoos; M M Davis
Minimal information about T cell assays: the process of reaching the community of T cell immunologists in cancer and beyond.
Cancer immunology, immunotherapy : CII 2011;60(1):15-22.
2010: Margit H Lampen; Marieke C Verweij; Bianca Querido; Sjoerd H van der burg; Emmanuel J H J Wiertz; Thorbald van Hall
CD8+ T cell responses against TAP-inhibited cells are readily detected in the human population.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(11):6508-17.
2010: Long V Ly; Marjolein Sluijter; Mieke Versluis; Gre P M Luyten; Sjoerd H van der burg; Cornelis J M Melief; Martine J Jager; Marianne J van Stipdonk; Thorbald van Hall
Peptide vaccination after T-cell transfer causes massive clonal expansion, tumor eradication, and manageable cytokine storm.
Cancer research 2010;70(21):8339-46.
2010: Sytse J Piersma; Jeanette M van der Hulst; Kitty M C Kwappenberg; Renske Goedemans; Caroline E van der Minne; Sjoerd H van der burg
Influenza matrix 1-specific human CD4+ FOXP3+ and FOXP3(-) regulatory T cells can be detected long after viral clearance.
European journal of immunology 2010;40(11):3064-74.
2010: Muriel van den Hende; Anke Redeker; Kitty M C Kwappenberg; Kees L M C Franken; Jan Wouter Drijfhout; Jaap Oostendorp; Rob Valentijn; Loraine M Fathers; Marij J P Welters; Cornelis J M Melief; Gemma G Kenter; Sjoerd H van der burg; Rienk Offringa
Evaluation of immunological cross-reactivity between clade A9 high-risk human papillomavirus types on the basis of E6-Specific CD4+ memory T cell responses.
The Journal of infectious diseases 2010;202(8):1200-11.
2010: Z Moodie; L Price; C Gouttefangeas; A Mander; S Janetzki; M Löwer; M J P Welters; C Ottensmeier; Sjoerd H van der burg; Cedrik M Britten
Response definition criteria for ELISPOT assays revisited.
Cancer immunology, immunotherapy : CII 2010;59(10):1489-501.
2010: Minka van Dongen; Nigel D L Savage; Ekaterina S. Jordanova; Inge H Briaire-de Bruijn; Kimberley V Walburg; Tom H M Ottenhoff; Pancras C W Hogendoorn; Sjoerd H van der burg; Hans Gelderblom; Thorbald van Hall
Anti-inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor-treated gastrointestinal stromal tumors.
International journal of cancer. Journal international du cancer 2010;127(4):899-909.
2010: Marij J P Welters; Gemma G Kenter; Peggy J de Vos van Steenwijk; Margriet J G Löwik; Dorien M A Berends-van der Meer; Farah Essahsah; Linda F M Stynenbosch; Annelies P G Vloon; Tamara H Ramwadhdoebe; Sytse J Piersma; Jeanette M van der Hulst; Rob Valentijn; Lorraine M Fathers; Jan Wouter Drijfhout; Kees L M C Franken; Jaap Oostendorp; Gert Jan Fleuren; Cornelis J M Melief; Sjoerd H van der burg
Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(26):11895-9.
2010: Peggy J de Vos van Steenwijk; Moniek Heusinkveld; Tamara H Ramwadhdoebe; Margriet J Löwik; Jeanette M van der Hulst; Renske Goedemans; Sytse J Piersma; Gemma G Kenter; Sjoerd H van der burg
An unexpectedly large polyclonal repertoire of HPV-specific T cells is poised for action in patients with cervical cancer.
Cancer research 2010;70(7):2707-17.
2010: Ann Mander; C Gouttefangeas; Christian H Ottensmeier; M J P Welters; L Low; Sjoerd H van der burg; C M Britten
Serum is not required for ex vivo IFN-gamma ELISPOT: a collaborative study of different protocols from the European CIMT Immunoguiding Program.
Cancer immunology, immunotherapy : CII 2010;59(4):619-27.
2010: Sylvia Janetzki; L Price; C M Britten; Sjoerd H van der burg; J Caterini; J R Currier; G Ferrari; C Gouttefangeas; P Hayes; E Kaempgen; V Lennerz; K Nihlmark; V Souza; A Hoos
Performance of serum-supplemented and serum-free media in IFNgamma Elispot Assays for human T cells.
Cancer immunology, immunotherapy : CII 2010;59(4):609-18.
2010: Cláudia C Oliveira; Peter van Veelen; Bianca Querido; Arnoud de Ru; Marjolein Sluijter; Sandra Laban; Jan W Drijfhout; Sjoerd H van der burg; Rienk Offringa; Thorbald van Hall
The nonpolymorphic MHC Qa-1b mediates CD8+ T cell surveillance of antigen-processing defects.
The Journal of experimental medicine 2010;207(1):207-21.
2010: Yin Ling Woo; Muriel van den Hende; Jane C Sterling; Nicholas Coleman; Robin A F Crawford; Kitty M C Kwappenberg; Margaret A Stanley; Sjoerd H van der burg
A prospective study on the natural course of low-grade squamous intraepithelial lesions and the presence of HPV16 E2-, E6- and E7-specific T-cell responses.
International journal of cancer. Journal international du cancer 2010;126(1):133-41.
2009: Gemma G Kenter; Marij J P Welters; Rob Valentijn; Margriet J G Lowik; Dorien M A Berends-van der Meer; Annelies P G Vloon; Farah Essahsah; Lorraine M Fathers; Rienk Offringa; Jan Wouter Drijfhout; Amon R Wafelman; Jaap Oostendorp; Gert Jan Fleuren; Sjoerd H van der burg; Cornelis J M Melief
Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia.
The New England journal of medicine 2009;361(19):1838-47.
2009: Ninke Leffers; Annechien J A Lambeck; Marloes J M Gooden; Baukje Nynke Hoogeboom; Rinze Wolf; Ineke E Hamming; Bouke G Hepkema; Pax H B Willemse; Barbara H W Molmans; Harry Hollema; Jan Wouter Drijfhout; Willem J Sluiter; Rob Valentijn; Loraine M Fathers; Jaap Oostendorp; Ate G J van der Zee; Cornelis J Melief; Sjoerd H van der burg; Toos Daemen; Hans W Nijman
Immunization with a P53 synthetic long peptide vaccine induces P53-specific immune responses in ovarian cancer patients, a phase II trial.
International journal of cancer. Journal international du cancer 2009;125(9):2104-13.
2009: Rezaul Karim; Ekaterina S. Jordanova; Sytse J Piersma; Gemma G Kenter; Lieping Chen; Judith M Boer; Cornelis J M Melief; Sjoerd H van der burg
Tumor-expressed B7-H1 and B7-DC in relation to PD-1+ T-cell infiltration and survival of patients with cervical carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(20):6341-7.
2009: Jimmy J Weterings; Selina Khan; Gerbrand J van der Heden van Noort; Cornelis J M Melief; Herman S Overkleeft; Sjoerd H van der burg; Ferry Ossendorp; Gijsbert A van der Marel; Dmitri V Filippov
2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation.
Bioorganic & medicinal chemistry letters 2009;19(8):2249-51.
2009: Selina Khan; Jimmy J Weterings; Cedrik Michael Britten; Ana R de Jong; Dirk Graafland; Cornelis J M Melief; Sjoerd H van der burg; Gijs van der Marel; Herman S Overkleeft; Dmitri V Filippov; Ferry Ossendorp
Chirality of TLR-2 ligand Pam3CysSK4 in fully synthetic peptide conjugates critically influences the induction of specific CD8+ T-cells.
Molecular immunology 2009;46(6):1084-91.
2009: Frank M Speetjens; Peter J K Kuppen; Marij J P Welters; Farah Essahsah; Anne Marie E G Voet van den Brink; M Graziella Kallenberg Lantrua; Rob Valentijn; Jaap Oostendorp; Lorraine M Fathers; Hans W Nijman; Jan Wouter Drijfhout; Cornelis J H van de Velde; Cornelis J M Melief; Sjoerd H van der burg
Induction of p53-specific immunity by a p53 synthetic long peptide vaccine in patients treated for metastatic colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(3):1086-95.
2009: Sjoerd H van der burg; Joel Palefsky
Human Immunodeficiency Virus and Human Papilloma Virus - why HPV-induced lesions do not spontaneously resolve and why therapeutic vaccination can be successful.
Journal of translational medicine 2009;7():108.
2008: Y L Woo; Jane Carolyn Sterling; I Damay; Nicholas Coleman; R Crawford; Sjoerd H van der burg; Margaret Stanley
Characterising the local immune responses in cervical intraepithelial neoplasia: a cross-sectional and longitudinal analysis.
BJOG : an international journal of obstetrics and gynaecology 2008;115(13):1616-21; discussion 1621-2.
2008: Peggy J de Vos van Steenwijk; Sytse J Piersma; Marij J P Welters; Jeanette M van der Hulst; Gert Jan Fleuren; Bart W J Hellebrekers; Gemma G Kenter; Sjoerd H van der burg
Surgery followed by persistence of high-grade squamous intraepithelial lesions is associated with the induction of a dysfunctional HPV16-specific T-cell response.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(22):7188-95.
2008: Rinke Bos; Suzanne van Duikeren; Hans Morreau; Kees L M C Franken; Schumacher Ton; John B Haanen; Sjoerd H van der burg; Cornelis J M Melief; Rienk Offringa
Balancing between antitumor efficacy and autoimmune pathology in T-cell-mediated targeting of carcinoembryonic antigen.
Cancer research 2008;68(20):8446-55.
2008: Marij J P Welters; Sytse J Piersma; Sjoerd H van der burg
T-regulatory cells in tumour-specific vaccination strategies.
Expert opinion on biological therapy 2008;8(9):1365-79.
2008: Frank M Speetjens; Marjolein M Lauwen; Kees L M C Franken; Connie M Janssen-Van Rhijn; Suzanne van Duikeren; Sandra A Bres; Cornelis J H van de Velde; Cornelis J M Melief; Peter Kuppen; Sjoerd H van der burg; Hans Morreau; Rienk Offringa
Prediction of the immunogenic potential of frameshift-mutated antigens in microsatellite instable cancer.
International journal of cancer. Journal international du cancer 2008;123(4):838-45.
2008: Frank M Speetjens; Peter Kuppen; Hans Morreau; Sjoerd H van der burg
Immune response against frameshift-induced neopeptides in HNPCC patients and healthy HNPCC mutation carriers.
Gastroenterology 2008;135(2):711-2; author reply 712-3.
2008: Y L Woo; Jane Carolyn Sterling; R Crawford; Sjoerd H van der burg; Nicholas Coleman; Margaret Stanley
FOXP3 immunohistochemistry on formalin-fixed paraffin-embedded tissue: poor correlation between different antibodies.
Journal of clinical pathology 2008;61(8):969-71.
2008: Muriel van den Hende; Mariëtte I E Van Poelgeest; Jeanette M van der Hulst; J de Jong; Jan Wouter Drijfhout; Gert Jan Fleuren; Rob Valentijn; Amon R Wafelman; Gijs M Slappendel; Cornelis J M Melief; Rienk Offringa; Sjoerd H van der burg; Gemma G Kenter
Skin reactions to human papillomavirus (HPV) 16 specific antigens intradermally injected in healthy subjects and patients with cervical neoplasia.
International journal of cancer. Journal international du cancer 2008;123(1):146-52.
2008: Cornelis J M Melief; Sjoerd H van der burg
Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines.
Nature reviews. Cancer 2008;8(5):351-60.
2008: Sytse J Piersma; Marij J P Welters; Sjoerd H van der burg
Tumor-specific regulatory T cells in cancer patients.
Human immunology 2008;69(4-5):241-9.
2008: Ekaterina S. Jordanova; Arko Gorter; Ouissam Ayachi; Frans A Prins; Lindy G Durrant; Gemma G Kenter; Sjoerd H van der burg; Gert Jan Fleuren
Human leukocyte antigen class I, MHC class I chain-related molecule A, and CD8+/regulatory T-cell ratio: which variable determines survival of cervical cancer patients?
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(7):2028-35.
2008: Martijn Bijker; Susan J F van den Eeden; Kees L M C Franken; Cornelis J M Melief; Sjoerd H van der burg; Rienk Offringa
Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation.
European journal of immunology 2008;38(4):1033-42.
2008: Cedrik Michael Britten; Cécile Gouttefangeas; Marij J P Welters; Graham Pawelec; Sven Koch; C Ottensmeier; A Mander; S Walter; Annette Paschen; Jan Muller-Berghaus; I Haas; Andreas Mackensen; Tania Køllgaard; Per thor Straten; M Schmitt; K Giannopoulos; R Maier; Hendrik Veelken; Cristina Bertinetti; Abdo Konur; Christoph Huber; S Stevanović; Thomas Wölfel; Sjoerd H van der burg
The CIMT-monitoring panel: a two-step approach to harmonize the enumeration of antigen-specific CD8+ T lymphocytes by structural and functional assays.
Cancer immunology, immunotherapy : CII 2008;57(3):289-302.
2008: Cedrik Michael Britten; Sylvia Janetzki; Sjoerd H van der burg; Cécile Gouttefangeas; A Hoos
Toward the harmonization of immune monitoring in clinical trials: quo vadis?
Cancer immunology, immunotherapy : CII 2008;57(3):285-8.
2008: Max Corbett; Willy M J M Bogers; Jonathan Luke Heeney; Stefan Gerber; Christian Genin; Arnaud Didierlaurent; Herman Oostermeijer; Rob Dubbes; Gerco Braskamp; Stéphanie Lerondel; Carmen E Gomez; Mariano Esteban; Ralf Wagner; Ivanella Kondova; Petra Mooij; Sunita S Balla-Jhagjhoorsingh; Niels Beenhakker; Gerrit Koopman; Sjoerd H van der burg; Jean-Pierre Kraehenbuhl; Alain Le Pape
Aerosol immunization with NYVAC and MVA vectored vaccines is safe, simple, and immunogenic.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(6):2046-51.
2008: Sjoerd H van der burg
Therapeutic vaccines in cancer: moving from immunomonitoring to immunoguiding.
Expert review of vaccines 2008;7(1):1-5.
2008: Marjolein M Lauwen; Sander Zwaveling; Linda de Quartel; Sandra C Ferreira Mota; Janine A C Grashorn; Cornelis J M Melief; Sjoerd H van der burg; Rienk Offringa
Self-tolerance does not restrict the CD4+ T-helper response against the p53 tumor antigen.
Cancer research 2008;68(3):893-900.
2008: Sytse J Piersma; Marij J P Welters; Jeanette M van der Hulst; Judith N Kloth; Kitty M C Kwappenberg; Baptist J Trimbos; Cornelis J M Melief; Bart W J Hellebrekers; Gert Jan Fleuren; Gemma G Kenter; Rienk Offringa; Sjoerd H van der burg
Human papilloma virus specific T cells infiltrating cervical cancer and draining lymph nodes show remarkably frequent use of HLA-DQ and -DP as a restriction element.
International journal of cancer. Journal international du cancer 2008;122(3):486-94.
2008: Marij J P Welters; Gemma G Kenter; Sytse J Piersma; Annelies P G Vloon; Margriet J G Löwik; Dorien M A Berends-van der Meer; Jan Wouter Drijfhout; Rob Valentijn; Amon R Wafelman; Jaap Oostendorp; Gert Jan Fleuren; Rienk Offringa; Cornelis J M Melief; Sjoerd H van der burg
Induction of tumor-specific CD4+ and CD8+ T-cell immunity in cervical cancer patients by a human papillomavirus type 16 E6 and E7 long peptides vaccine.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(1):178-87.
2008: Gemma G Kenter; Marij J P Welters; Rob Valentijn; Margriet J G Lowik; Dorien M A Berends-van der Meer; Annelies P G Vloon; Jan Wouter Drijfhout; Amon R Wafelman; Jaap Oostendorp; Gert Jan Fleuren; Rienk Offringa; Sjoerd H van der burg; Cornelis J M Melief
Phase I immunotherapeutic trial with long peptides spanning the E6 and E7 sequences of high-risk human papillomavirus 16 in end-stage cervical cancer patients shows low toxicity and robust immunogenicity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(1):169-77.
2007: Marjon A de Boer; Ekaterina S. Jordanova; Mariëtte I E Van Poelgeest; Brendy E van den Akker; Sjoerd H van der burg; Gemma G Kenter; Gert Jan Fleuren
Circulating human papillomavirus type 16 specific T-cells are associated with HLA Class I expression on tumor cells, but not related to the amount of viral oncogene transcripts.
International journal of cancer. Journal international du cancer 2007;121(12):2711-5.
2007: Rinke Bos; Suzanne van Duikeren; Thorbald van Hall; Marjolein M Lauwen; Mark Parrington; Neil L Berinstein; Bryan McNeil; Cornelis J M Melief; Sjef Verbeek; Sjoerd H van der burg; Rienk Offringa
Characterization of antigen-specific immune responses induced by canarypox virus vaccines.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):6115-22.
2007: Martijn Bijker; Susan J F van den Eeden; Kees L M C Franken; Cornelis J M Melief; Rienk Offringa; Sjoerd H van der burg
CD8+ CTL priming by exact peptide epitopes in incomplete Freund's adjuvant induces a vanishing CTL response, whereas long peptides induce sustained CTL reactivity.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(8):5033-40.
2007: Martijn Bijker; Cornelis J M Melief; Rienk Offringa; Sjoerd H van der burg
Design and development of synthetic peptide vaccines: past, present and future.
Expert review of vaccines 2007;6(4):591-603.
2007: Annechien J A Lambeck; Ninke Leffers; Baukje Nynke Hoogeboom; Wim Sluiter; Ineke Hamming; Harry Klip; Klaske A ten Hoor; Martha Esajas; Magda van Oven; Jan Wouter Drijfhout; Inge Platteel; Rienk Offringa; Harry Hollema; Kees Melief; Sjoerd H van der burg; Ate van der Zee; Toos Daemen; Hans W Nijman
P53-specific T cell responses in patients with malignant and benign ovarian tumors: implications for p53 based immunotherapy.
International journal of cancer. Journal international du cancer 2007;121(3):606-14.
2007: Selina Khan; Martijn Bijker; Jimmy J Weterings; Hans J Tanke; Gosse J Adema; Thorbald van Hall; Jan Wouter Drijfhout; Cornelis J M Melief; Herman S Overkleeft; Gijsbert A van der Marel; Dmitri V Filippov; Sjoerd H van der burg; Ferry Ossendorp
Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells.
The Journal of biological chemistry 2007;282(29):21145-59.
2007: Sjoerd H van der burg; Sytse J Piersma; Annemieke de Jong; Jeanette M van der Hulst; Kitty M C Kwappenberg; Muriel van den Hende; Marij J P Welters; Jon van Rood; Gert Jan Fleuren; Cornelis J M Melief; Gemma G Kenter; Rienk Offringa
Association of cervical cancer with the presence of CD4+ regulatory T cells specific for human papillomavirus antigens.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(29):12087-92.
2007: Akash M Mehta; Ekaterina S. Jordanova; Tom van Wezel; Hae-Won Uh; Willem E Corver; Kitty M C Kwappenberg; Willem Verduijn; Gemma G Kenter; Sjoerd H van der burg; Gert Jan Fleuren
Genetic variation of antigen processing machinery components and association with cervical carcinoma.
Genes, chromosomes & cancer 2007;46(6):577-86.
2007: Stefanie Loeser; Karin Loser; Martijn Bijker; Manu Rangachari; Sjoerd H van der burg; Teiji Wada; Stefan Beissert; Cornelis J M Melief; Josef M Penninger
Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells.
The Journal of experimental medicine 2007;204(4):879-91.
2007: Marij J P Welters; Martijn Bijker; Susan J F van den Eeden; Kees L M C Franken; Cornelis J M Melief; Rienk Offringa; Sjoerd H van der burg
Multiple CD4 and CD8 T-cell activation parameters predict vaccine efficacy in vivo mediated by individual DC-activating agonists.
Vaccine 2007;25(8):1379-89.
2007: Sytse J Piersma; Ekaterina S. Jordanova; Mariëtte I E Van Poelgeest; Kitty M C Kwappenberg; Jeanette M van der Hulst; Jan Wouter Drijfhout; Cornelis J M Melief; Gemma G Kenter; Gert Jan Fleuren; Rienk Offringa; Sjoerd H van der burg
High number of intraepithelial CD8+ tumor-infiltrating lymphocytes is associated with the absence of lymph node metastases in patients with large early-stage cervical cancer.
Cancer research 2007;67(1):354-61.
2006: Sjoerd H van der burg; Martijn Bijker; Marij J P Welters; Rienk Offringa; Cornelis J M Melief
Improved peptide vaccine strategies, creating synthetic artificial infections to maximize immune efficacy.
Advanced drug delivery reviews 2006;58(8):916-30.
2006: Jimmy J Weterings; Selina Khan; Gerbrand J van der Heden; Jan Wouter Drijfhout; Cornelis J M Melief; Herman S Overkleeft; Sjoerd H van der burg; Ferry Ossendorp; Gijsbert A van der Marel; Dmitri V Filippov
Synthesis of 2-alkoxy-8-hydroxyadenylpeptides: towards synthetic epitope-based vaccines.
Bioorganic & medicinal chemistry letters 2006;16(12):3258-61.
2006: Marieke Griffioen; Jan H. Kessler; Martina Borghi; Ronald A van Soest; Caroline E van der Minne; Jan Nouta; Sjoerd H van der burg; Jan Paul Medema; Peter I Schrier; J H Frederik Falkenburg; Susanne Osanto; Cornelis J M Melief
Detection and functional analysis of CD8+ T cells specific for PRAME: a target for T-cell therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(10):3130-6.
2006: Marij J P Welters; Pauline van der Logt; Susan J F van den Eeden; Kitty M C Kwappenberg; Jan Wouter Drijfhout; Gert Jan Fleuren; Gemma G Kenter; Cornelis J M Melief; Sjoerd H van der burg; Rienk Offringa
Detection of human papillomavirus type 18 E6 and E7-specific CD4+ T-helper 1 immunity in relation to health versus disease.
International journal of cancer. Journal international du cancer 2006;118(4):950-6.
2006: Mariëtte I E Van Poelgeest; Esther R Nijhuis; Kitty M C Kwappenberg; Ineke E Hamming; Jan Wouter Drijfhout; Gert Jan Fleuren; Ate G J van der Zee; Cornelis J M Melief; Gemma G Kenter; Hans W Nijman; Rienk Offringa; Sjoerd H van der burg
Distinct regulation and impact of type 1 T-cell immunity against HPV16 L1, E2 and E6 antigens during HPV16-induced cervical infection and neoplasia.
International journal of cancer. Journal international du cancer 2006;118(3):675-83.
2006: Federica Cavallo; Rienk Offringa; Sjoerd H van der burg; Guido Forni; Cornelis J M Melief
Vaccination for treatment and prevention of cancer in animal models.
Advances in immunology 2006;90():175-213.
2005: Andrea Vambutas; James A DeVoti; May Nouri; J W Drijfhout; Grayson Lipford; Vincent Bonagura; Sjoerd H van der burg; Cornelis J M Melief
Therapeutic vaccination with papillomavirus E6 and E7 long peptides results in the control of both established virus-induced lesions and latently infected sites in a pre-clinical cottontail rabbit papillomavirus model.
Vaccine 2005;23(45):5271-80.
2005: Hans W Nijman; Annechien J A Lambeck; Sjoerd H van der burg; Ate G J van der Zee; Toos Daemen
Immunologic aspect of ovarian cancer and p53 as tumor antigen.
Journal of translational medicine 2005;3():34.
2005: Mariëtte I E Van Poelgeest; Manon van Seters; Marc van Beurden; Kitty M C Kwappenberg; Claudia Heijmans-Antonissen; Jan Wouter Drijfhout; Cornelis J M Melief; Gemma G Kenter; Theo J M Helmerhorst; Rienk Offringa; Sjoerd H van der burg
Detection of human papillomavirus (HPV) 16-specific CD4+ T-cell immunity in patients with persistent HPV16-induced vulvar intraepithelial neoplasia in relation to clinical impact of imiquimod treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(14):5273-80.
2005: Y G L De Graaf; Daniel Schiefer; Anke Redeker; Bert Jan Vermeer; Jan Nico Bouwes Bavinck; Rein Willemze; Frank R de Gruijl; Sjoerd H van der burg
p53-specific serum antibodies are not associated with a history of skin carcinoma in renal transplant recipients and immunocompetent individuals.
Journal of dermatological science 2005;38(3):228-30.
2005: Maro H Sandel; Alisher R Dadabayev; Anand G Menon; Hans Morreau; Cornelis J M Melief; Rienk Offringa; Sjoerd H van der burg; Connie M Janssen-Van Rhijn; N Geeske Ensink; R A E M Tollenaar; Cornelis J H van de Velde; Peter Kuppen
Prognostic value of tumor-infiltrating dendritic cells in colorectal cancer: role of maturation status and intratumoral localization.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(7):2576-82.
2005: Annemieke de Jong; Jeanette M van der Hulst; Gemma G Kenter; Jan Wouter Drijfhout; Kees L M C Franken; Pieter Vermeij; Rienk Offringa; Sjoerd H van der burg; Cornelis J M Melief
Rapid enrichment of human papillomavirus (HPV)-specific polyclonal T cell populations for adoptive immunotherapy of cervical cancer.
International journal of cancer. Journal international du cancer 2005;114(2):274-82.
2004: Marij J P Welters; Dmitri V Filippov; Susan J F van den Eeden; Kees L M C Franken; Jan Nouta; Rob Valentijn; Gijsbert A van der Marel; Herman S Overkleeft; Grayson Lipford; Rienk Offringa; Cornelis J M Melief; Jacques H van Boom; Sjoerd H van der burg; Jan Wouter Drijfhout
Chemically synthesized protein as tumour-specific vaccine: immunogenicity and efficacy of synthetic HPV16 E7 in the TC-1 mouse tumour model.
Vaccine 2004;23(3):305-11.
2004: Alisher R Dadabayev; Maro H Sandel; Anand G Menon; Hans Morreau; Cornelis J M Melief; Rienk Offringa; Sjoerd H van der burg; Connie M Janssen-Van Rhijn; N Geeske Ensink; R A E M Tollenaar; Cornelis J H van de Velde; Peter Kuppen
Dendritic cells in colorectal cancer correlate with other tumor-infiltrating immune cells.
Cancer immunology, immunotherapy : CII 2004;53(11):978-86.
2004: Jan H. Kessler; Willemien E Benckhuijsen; Tuna Mutis; Cornelis J M Melief; Sjoerd H van der burg; Jan Wouter Drijfhout
Competition-based cellular peptide binding assay for HLA class I.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2004;Chapter 18():Unit 18.12.
2004: Annemieke de Jong; Mariëtte I E Van Poelgeest; Jeanette M van der Hulst; Jan Wouter Drijfhout; Gert Jan Fleuren; Cornelis J M Melief; Gemma G Kenter; Rienk Offringa; Sjoerd H van der burg
Human papillomavirus type 16-positive cervical cancer is associated with impaired CD4+ T-cell immunity against early antigens E2 and E6.
Cancer research 2004;64(15):5449-55.
2004: Lucy J C Smyth; Mariëtte I E Van Poelgeest; Emma J Davidson; Kitty M C Kwappenberg; Debbie Burt; Peter Sehr; Michael Pawlita; Stephen Man; Julian Hickling; Alison Fiander; Amanda Tristram; Henry C Kitchener; Rienk Offringa; Peter L Stern; Sjoerd H van der burg
Immunological responses in women with human papillomavirus type 16 (HPV-16)-associated anogenital intraepithelial neoplasia induced by heterologous prime-boost HPV-16 oncogene vaccination.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(9):2954-61.
2003: Arend Mulder; Chantal Eijsink; Marrie J Kardol; Marry E I Franke-van Dijk; Sjoerd H van der burg; Michel Kester; Ilias Doxiadis; Frans H J Claas
Identification, isolation, and culture of HLA-A2-specific B lymphocytes using MHC class I tetramers.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6599-603.
2003: Sjoerd H van der burg; Anand G Menon; Anke Redeker; Kees L M C Franken; Jan Wouter Drijfhout; R A E M Tollenaar; Henk H Hartgrink; Cornelis J H van de Velde; Peter Kuppen; Cornelis J M Melief; Rienk Offringa
Magnitude and polarization of P53-specific T-helper immunity in connection to leukocyte infiltration of colorectal tumors.
International journal of cancer. Journal international du cancer 2003;107(3):425-33.
2003: Peter J W Baldwin; Sjoerd H van der burg; Christopher M Boswell; Rienk Offringa; Julian Hickling; Jennifer Dobson; John St Clair Roberts; John A Latimer; Robin P Moseley; Nicholas Coleman; Margaret A Stanley; Jane C Sterling
Vaccinia-expressed human papillomavirus 16 and 18 e6 and e7 as a therapeutic vaccination for vulval and vaginal intraepithelial neoplasia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(14):5205-13.
2003: Anand G Menon; Peter Kuppen; Sjoerd H van der burg; Rienk Offringa; Marie-Claude Bonnet; Bert I J Harinck; R A E M Tollenaar; Anke Redeker; Hein Putter; Philippe Moingeon; Hans Morreau; Cornelis J M Melief; Cornelis J H van de Velde
Safety of intravenous administration of a canarypox virus encoding the human wild-type p53 gene in colorectal cancer patients.
Cancer gene therapy 2003;10(7):509-17.
2003: Marij J P Welters; Annemieke de Jong; Susan J F van den Eeden; Jeanette M van der Hulst; Kitty M C Kwappenberg; Sabrin Hassane; Kees L M C Franken; Jan Wouter Drijfhout; Gert Jan Fleuren; Gemma G Kenter; Cornelis J M Melief; Rienk Offringa; Sjoerd H van der burg
Frequent display of human papillomavirus type 16 E6-specific memory t-Helper cells in the healthy population as witness of previous viral encounter.
Cancer research 2003;63(3):636-41.
2003: Jan H. Kessler; Bregje Mommaas; Tuna Mutis; Ivo Huijbers; Debby Vissers; Willemien Benckhuijsen; G M Th Schreuder; Rienk Offringa; Els Goulmy; Cornelis J M Melief; Sjoerd H van der burg; Jan Wouter Drijfhout
Competition-based cellular peptide binding assays for 13 prevalent HLA class I alleles using fluorescein-labeled synthetic peptides.
Human immunology 2003;64(2):245-55.
2003: R Offringa; A de Jong; René E M Toes; Sjoerd H van der burg; Cornelis J M Melief
Interplay between human papillomaviruses and dendritic cells.
Current topics in microbiology and immunology 2003;276():215-40.
2002: Sjoerd H van der burg; Annemieke de Jong; Marij J P Welters; Rienk Offringa; Cornelis J M Melief
The status of HPV16-specific T-cell reactivity in health and disease as a guide to HPV vaccine development.
Virus research 2002;89(2):275-84.
2002: Sander Zwaveling; Michel P M Vierboom; Sandra C Ferreira Mota; Jennifer A Hendriks; Marlies E Ooms; Roger P M Sutmuller; Kees L M C Franken; Hans W Nijman; Ferry Ossendorp; Sjoerd H van der burg; Rienk Offringa; Cornelis J M Melief
Antitumor efficacy of wild-type p53-specific CD4(+) T-helper cells.
Cancer research 2002;62(21):6187-93.
2002: Annemieke de Jong; T O'Neill; A Y Khan; Kitty M C Kwappenberg; S E Chisholm; N R Whittle; J A Dobson; L C Jack; J A St Clair Roberts; Rienk Offringa; Sjoerd H van der burg; Julian Hickling
Enhancement of human papillomavirus (HPV) type 16 E6 and E7-specific T-cell immunity in healthy volunteers through vaccination with TA-CIN, an HPV16 L2E7E6 fusion protein vaccine.
Vaccine 2002;20(29-30):3456-64.
2002: Cornelis J M Melief; Sjoerd H van der burg; René E M Toes; Ferry Ossendorp; Rienk Offringa
Effective therapeutic anticancer vaccines based on precision guiding of cytolytic T lymphocytes.
Immunological reviews 2002;188():177-82.
2002: Sander Zwaveling; Sandra C Ferreira Mota; Jan Nouta; Mark Johnson; Grayson Lipford; Rienk Offringa; Sjoerd H van der burg; Cornelis J M Melief
Established human papillomavirus type 16-expressing tumors are effectively eradicated following vaccination with long peptides.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):350-8.
2002: Sjoerd H van der burg; Anand G Menon; Anke Redeker; Marie-Claude Bonnet; Jan Wouter Drijfhout; R A E M Tollenaar; Cornelis J H van de Velde; Philippe Moingeon; Peter Kuppen; Rienk Offringa; Cornelis J M Melief
Induction of p53-specific immune responses in colorectal cancer patients receiving a recombinant ALVAC-p53 candidate vaccine.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(5):1019-27.
2002: Annemieke de Jong; Sjoerd H van der burg; Kitty M C Kwappenberg; Jeanette M van der Hulst; Kees L M C Franken; Annemieke Geluk; Krista E van Meijgaarden; Jan Wouter Drijfhout; Gemma G Kenter; Pieter Vermeij; Cornelis J M Melief; Rienk Offringa
Frequent detection of human papillomavirus 16 E2-specific T-helper immunity in healthy subjects.
Cancer research 2002;62(2):472-9.
2002: Sander Zwaveling; Sjoerd H van der burg; Anand G Menon; Cornelis J M Melief; Rienk Offringa
Immunotherapy of cancer through targeting of the p53 tumor antigen.
Archivum immunologiae et therapiae experimentalis 2002;50(5):297-305.
2001: Sjoerd H van der burg; Kitty M C Kwappenberg; T O'Neill; RM Brandt; Cornelis J M Melief; Julian Hickling; Rienk Offringa
Pre-clinical safety and efficacy of TA-CIN, a recombinant HPV16 L2E6E7 fusion protein vaccine, in homologous and heterologous prime-boost regimens.
Vaccine 2001;19(27):3652-60.
2001: Sjoerd H van der burg; Maaike E Ressing; Kitty M C Kwappenberg; Annemieke de Jong; K Straathof; J de Jong; Annemieke Geluk; Krista E van Meijgaarden; Kees L M C Franken; Tom H M Ottenhoff; Gert Jan Fleuren; Gemma G Kenter; Cornelis J M Melief; Rienk Offringa
Natural T-helper immunity against human papillomavirus type 16 (HPV16) E7-derived peptide epitopes in patients with HPV16-positive cervical lesions: identification of 3 human leukocyte antigen class II-restricted epitopes.
International journal of cancer. Journal international du cancer 2001;91(5):612-8.
2001: Lukas Heukamp; Sjoerd H van der burg; J W Drijfhout; Cornelis J M Melief; Joyce Taylor-Papadimitriou; Rienk Offringa
Identification of three non-VNTR MUC1-derived HLA-A*0201-restricted T-cell epitopes that induce protective anti-tumor immunity in HLA-A2/K(b)-transgenic mice.
International journal of cancer. Journal international du cancer 2001;91(3):385-92.
2001: Sjoerd H van der burg; K de Cock; Anand G Menon; Kees L M C Franken; M Palmen; Anke Redeker; Jan Wouter Drijfhout; Peter Kuppen; Cornelis J H van de Velde; L Erdile; R A E M Tollenaar; Cornelis J M Melief; Rienk Offringa
Long lasting p53-specific T cell memory responses in the absence of anti-p53 antibodies in patients with resected primary colorectal cancer.
European journal of immunology 2001;31(1):146-55.
2000: Rienk Offringa; Sjoerd H van der burg; Ferry Ossendorp; R E Toes; C J Melief
Design and evaluation of antigen-specific vaccination strategies against cancer.
Current opinion in immunology 2000;12(5):576-82.
2000: Ferry Ossendorp; René E M Toes; Rienk Offringa; Sjoerd H van der burg; Cornelis J M Melief
Importance of CD4(+) T helper cell responses in tumor immunity.
Immunology letters 2000;74(1):75-9.
2000: Rienk Offringa; Michel P M Vierboom; Sjoerd H van der burg; L Erdile; Cornelis J M Melief
p53: a potential target antigen for immunotherapy of cancer.
Annals of the New York Academy of Sciences 2000;910():223-33; discussion 233-6.
2000: Cornelis J M Melief; René E M Toes; Jan Paul Medema; Sjoerd H van der burg; Ferry Ossendorp; Rienk Offringa
Strategies for immunotherapy of cancer.
Advances in immunology 2000;75():235-82.
1999: Andreas Kammer; Sjoerd H van der burg; Benno Grabscheid; Isabelle P Hunziker; Kitty M C Kwappenberg; Jürg Reichen; Cornelis J M Melief; Andreas Cerny
Molecular mimicry of human cytochrome P450 by hepatitis C virus at the level of cytotoxic T cell recognition.
The Journal of experimental medicine 1999;190(2):169-76.
1999: Sjoerd H van der burg; Kitty M C Kwappenberg; Annemieke Geluk; M van der Kruk; Oscar Pontesilli; Egbert Hovenkamp; Kees L M C Franken; Krista E van Meijgaarden; Jan Wouter Drijfhout; Tom H M Ottenhoff; Cornelis J M Melief; Rienk Offringa
Identification of a conserved universal Th epitope in HIV-1 reverse transcriptase that is processed and presented to HIV-specific CD4+ T cells by at least four unrelated HLA-DR molecules.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):152-60.
1998: Michel Klein; Sjoerd H van der burg; Egbert Hovenkamp; AM Holwerda; Jan Wouter Drijfhout; Cornelis J M Melief; Frank Miedema
Characterization of HLA-B57-restricted human immunodeficiency virus type 1 Gag- and RT-specific cytotoxic T lymphocyte responses.
The Journal of general virology 1998;79 ( Pt 9)():2191-201.
1998: Michel Klein; Sjoerd H van der burg; Oscar Pontesilli; Frank Miedema
Cytotoxic T lymphocytes in HIV-1 infection: a killing paradox?
Immunology today 1998;19(7):317-24.
1997: S C Klein; Sjoerd H van der burg; L H Boer; C J Melief; W M Kast; Gijsbert C De Gast; bert bast
Targeting of cytotoxic T cells against leukemic B cells by bispecific antibody (aCD3 x aCD19) does not distract the T cell from its primary target.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(11):5545-9.
1997: Sjoerd H van der burg; Michel Klein; Oscar Pontesilli; AM Holwerda; Jan Wouter Drijfhout; W M Kast; Frank Miedema; Cornelis J M Melief
HIV-1 reverse transcriptase-specific CTL against conserved epitopes do not protect against progression to AIDS.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3648-54.
1997: MJ Visseren; Sjoerd H van der burg; Ellen I H van der Voort; RM Brandt; Peter I Schrier; P van der Bruggen; T Boon; Cornelis J M Melief; W Martin Kast
Identification of HLA-A*0201-restricted CTL epitopes encoded by the tumor-specific MAGE-2 gene product.
International journal of cancer. Journal international du cancer 1997;73(1):125-30.
1997: MJ Visseren; Sjoerd H van der burg; GE Hawes; Ellen I H van der Voort; Peter J van den Elsen; Cornelis J M Melief
Affinity, specificity and T-cell-receptor diversity of melanoma-specific CTL generated in vitro against a single tyrosinase epitope.
International journal of cancer. Journal international du cancer 1997;72(6):1122-8.
1997: E Ras; Sjoerd H van der burg; S T Zegveld; RM Brandt; Peter Kuppen; Rienk Offringa; S O Warnarr; C J van de Velde; Cornelis J M Melief
Identification of potential HLA-A *0201 restricted CTL epitopes derived from the epithelial cell adhesion molecule (Ep-CAM) and the carcinoembryonic antigen (CEA).
Human immunology 1997;53(1):81-9.
1997: Sjoerd H van der burg; MJ Visseren; R Offringa; C J Melief
Do epitopes derived from autoantigens display low affinity for MHC class I?
Immunology today 1997;18(2):97-8.
1997: A B Bakker; Sjoerd H van der burg; Richard Huijbens; J W Drijfhout; C J Melief; Gosse J Adema; Carl G Figdor
Analogues of CTL epitopes with improved MHC class-I binding capacity elicit anti-melanoma CTL recognizing the wild-type epitope.
International journal of cancer. Journal international du cancer 1997;70(3):302-9.
1996: M Röpke; J Hald; Per Guldberg; Jesper Zeuthen; L Nørgaard; Lars Fugger; Arne Svejgaard; Sjoerd H van der burg; H W Nijman; C J Melief; Mogens H Claesson
Spontaneous human squamous cell carcinomas are killed by a human cytotoxic T lymphocyte clone recognizing a wild-type p53-derived peptide.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14704-7.
1996: A van Elsas; Sjoerd H van der burg; C E van der Minne; M Borghi; J S Mourer; Cornelis J M Melief; Peter I Schrier
Peptide-pulsed dendritic cells induce tumoricidal cytotoxic T lymphocytes from healthy donors against stably HLA-A*0201-binding peptides from the Melan-A/MART-1 self antigen.
European journal of immunology 1996;26(8):1683-9.
1996: Sjoerd H van der burg; M J Visseren; RM Brandt; W Martin Kast; Cornelis J M Melief
Immunogenicity of peptides bound to MHC class I molecules depends on the MHC-peptide complex stability.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(9):3308-14.
1995: Sjoerd H van der burg; E Ras; Jan Wouter Drijfhout; Willemien Benckhuijsen; A J Bremers; Cornelis J M Melief; W Martin Kast
An HLA class I peptide-binding assay based on competition for binding to class I molecules on intact human B cells. Identification of conserved HIV-1 polymerase peptides binding to HLA-A*0301.
Human immunology 1995;44(4):189-98.
1995: J G Houbiers; Sjoerd H van der burg; L M G van de Watering; R A Tollenaar; Anneke Brand; Cornelis J H van de Velde; Cornelis J M Melief
Antibodies against p53 are associated with poor prognosis of colorectal cancer.
British journal of cancer 1995;72(3):637-41.
1995: M C Feltkamp; G R Vreugdenhil; Michel P M Vierboom; E Ras; Sjoerd H van der burg; Jan ter Schegget; Cornelis J M Melief; W Martin Kast
Cytotoxic T lymphocytes raised against a subdominant epitope offered as a synthetic peptide eradicate human papillomavirus type 16-induced tumors.
European journal of immunology 1995;25(9):2638-42.
1995: A J Bremers; Sjoerd H van der burg; Peter Kuppen; W Martin Kast; Cornelis J H van de Velde; C J Melief
The use of Epstein-Barr virus-transformed B lymphocyte cell lines in a peptide-reconstitution assay: identification of CEA-related HLA-A*0301-restricted potential cytotoxic T-lymphocyte epitopes.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1995;18(2):77-85.
1995: B E Ballieux; Sjoerd H van der burg; Chris Hagen; Fokko J van der Woude; C J Melief; Mohamed R Daha
Cell-mediated autoimmunity in patients with Wegener's granulomatosis (WG)
Clinical and experimental immunology 1995;100(2):186-93.
1995: Sjoerd H van der burg; Michel Klein; Cornelis J H van de Velde; W Martin Kast; Frank Miedema; Cornelis J M Melief
Induction of a primary human cytotoxic T-lymphocyte response against a novel conserved epitope in a functional sequence of HIV-1 reverse transcriptase.
AIDS (London, England) 1995;9(2):121-7.
1994: HW Nijman; Sjoerd H van der burg; Michel P M Vierboom; J G Houbiers; W Martin Kast; Cornelis J M Melief
p53, a potential target for tumor-directed T cells.
Immunology letters 1994;40(2):171-8.
1993: J G Houbiers; HW Nijman; Sjoerd H van der burg; Jan Wouter Drijfhout; Peter Kenemans; Cornelis J H van de Velde; Anneke Brand; F Momburg; W Martin Kast; Cornelis J M Melief
In vitro induction of human cytotoxic T lymphocyte responses against peptides of mutant and wild-type p53.
European journal of immunology 1993;23(9):2072-7.
1993: HW Nijman; J G Houbiers; Sjoerd H van der burg; Michel P M Vierboom; Peter Kenemans; W Martin Kast; Cornelis J M Melief
Characterization of cytotoxic T lymphocyte epitopes of a self-protein, p53, and a non-self-protein, influenza matrix: relationship between major histocompatibility complex peptide binding affinity and immune responsiveness to peptides.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1993;14(2):121-6.
1993: HW Nijman; J G Houbiers; Michel P M Vierboom; Sjoerd H van der burg; Jan Wouter Drijfhout; Joe D'Amaro; Peter Kenemans; Cornelis J M Melief; W Martin Kast
Identification of peptide sequences that potentially trigger HLA-A2.1-restricted cytotoxic T lymphocytes.
European journal of immunology 1993;23(6):1215-9.
1993: Pancras Hogendoorn; E B van Dorst; Sjoerd H van der burg; Jan A Bruijn; Mohamed R Daha; P J Hoedemaeker; Gert Jan Fleuren
Antigen size influences the type of glomerular pathology in chronic serum sickness.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1993;8(8):703-10.