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Cyrille Cohen

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Chemicals & Drugs

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Stephanie L Goff; Laura A Johnson; Mary A Black; Hui Xu; Zhili Zheng; Cyrille Cohen; Richard A Morgan; STEVEN ROSENBERG; Steven A Feldman
Enhanced receptor expression and in vitro effector function of a murine-human hybrid MART-1-reactive T cell receptor following a rapid expansion.
Gil Bialer; Miryam Horovitz-Fried; Shlomo Ya'acobi; Richard A Morgan; Cyrille Cohen
Selected murine residues endow human TCR with enhanced tumor recognition.
P D Peng; Cyrille Cohen; S Yang; C Hsu; S Jones; Yangbing Zhao; Zhili Zheng; STEVEN ROSENBERG; Richard A Morgan
Efficient nonviral Sleeping Beauty transposon-based TCR gene transfer to peripheral blood lymphocytes confers antigen-specific antitumor reactivity.

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All Publications

2010: Stephanie L Goff; Laura A Johnson; Mary A Black; Hui Xu; Zhili Zheng; Cyrille Cohen; Richard A Morgan; STEVEN ROSENBERG; Steven A Feldman
Enhanced receptor expression and in vitro effector function of a murine-human hybrid MART-1-reactive T cell receptor following a rapid expansion.
Cancer immunology, immunotherapy : CII 2010;59(10):1551-60.
2010: Gil Bialer; Miryam Horovitz-Fried; Shlomo Ya'acobi; Richard A Morgan; Cyrille Cohen
Selected murine residues endow human TCR with enhanced tumor recognition.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(11):6232-41.
2009: P D Peng; Cyrille Cohen; S Yang; C Hsu; S Jones; Yangbing Zhao; Zhili Zheng; STEVEN ROSENBERG; Richard A Morgan
Efficient nonviral Sleeping Beauty transposon-based TCR gene transfer to peripheral blood lymphocytes confers antigen-specific antitumor reactivity.
Gene therapy 2009;16(8):1042-9.
2009: Stephanie Jones; Peter D Peng; Shicheng Yang; Cary Hsu; Cyrille Cohen; Yangbing Zhao; John Abad; Zhili Zheng; STEVEN ROSENBERG; Richard A Morgan
Lentiviral vector design for optimal T cell receptor gene expression in the transduction of peripheral blood lymphocytes and tumor-infiltrating lymphocytes.
Human gene therapy 2009;20(6):630-40.
2008: Marc R Theoret; Cyrille Cohen; Azam V Nahvi; Lien T Ngo; Kimberly B Suri; Daniel J Powell; Mark E Dudley; Richard A Morgan; STEVEN ROSENBERG
Relationship of p53 overexpression on cancers and recognition by anti-p53 T cell receptor-transduced T cells.
Human gene therapy 2008;19(11):1219-32.
2008: S Yang; Cyrille Cohen; P D Peng; Yangbing Zhao; L Cassard; Z Yu; Zhili Zheng; S Jones; Nicholas P Restifo; STEVEN ROSENBERG; Richard A Morgan
Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognition.
Gene therapy 2008;15(21):1411-23.
2008: John D Abad; Claudia Wrzensinski; Willem W Overwijk; Moniek A De Witte; Annelies Jorritsma; Cary Hsu; Luca Gattinoni; Cyrille Cohen; Chrystal M Paulos; Douglas Palmer; John B A G Haanen; Schumacher Ton; STEVEN ROSENBERG; Nicholas P Restifo; Richard A Morgan
T-cell receptor gene therapy of established tumors in a murine melanoma model.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2008;31(1):1-6.
2007: Cary Hsu; Stephanie A Jones; Cyrille Cohen; Zhili Zheng; Kimberly F Kerstann; Juhua Zhou; Paul F Robbins; Peter D Peng; Xinglei Shen; Theotonius J Gomes; Cynthia E Dunbar; David J Munroe; Claudia Stewart; Kenneth Cornetta; Danny Wangsa; Thomas Ried; STEVEN ROSENBERG; Richard A Morgan
Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene.
Blood 2007;109(12):5168-77.
2007: Cyrille Cohen; Yong F Li; Mona El-Gamil; Paul F Robbins; STEVEN ROSENBERG; Richard A Morgan
Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond.
Cancer research 2007;67(8):3898-903.
2007: Yangbing Zhao; Maria R Parkhurst; Zhili Zheng; Cyrille Cohen; John P Riley; Luca Gattinoni; Nicholas P Restifo; STEVEN ROSENBERG; Richard A Morgan
Extrathymic generation of tumor-specific T cells from genetically engineered human hematopoietic stem cells via Notch signaling.
Cancer research 2007;67(6):2425-9.
2006: Dietmar Zehn; Cyrille Cohen; Yoram Reiter; Peter Walden
Efficiency of peptide presentation by dendritic cells compared with other cell types: implications for cross-priming.
International immunology 2006;18(12):1647-54.
2006: Laura A Johnson; Bianca Heemskerk; Daniel J Powell; Cyrille Cohen; Richard A Morgan; Mark E Dudley; Paul F Robbins; STEVEN ROSENBERG
Gene transfer of tumor-reactive TCR confers both high avidity and tumor reactivity to nonreactive peripheral blood mononuclear cells and tumor-infiltrating lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6548-59.
2006: Cyrille Cohen; Yangbing Zhao; Zhili Zheng; STEVEN ROSENBERG; Richard A Morgan
Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability.
Cancer research 2006;66(17):8878-86.
2006: Yangbing Zhao; Zhili Zheng; Cyrille Cohen; Luca Gattinoni; Douglas Palmer; Nicholas P Restifo; STEVEN ROSENBERG; Richard A Morgan
High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(1):151-9.
2005: Cyrille Cohen; Zhili Zheng; Regina Bray; Yangbing Zhao; Linda A Sherman; STEVEN ROSENBERG; Richard A Morgan
Recognition of fresh human tumor by human peripheral blood lymphocytes transduced with a bicistronic retroviral vector encoding a murine anti-p53 TCR.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5799-808.
2004: Gerhard Held; Mitsutoshi Matsuo; Malka Epel; Sacha Gnjatic; Gerd Ritter; Sang-Yull Lee; Tsin Yee Tai; Cyrille Cohen; Lloyd J Old; Michael Pfreundschuh; Yoram Reiter; Hennie Hoogenboom; Christoph Renner
Dissecting cytotoxic T cell responses towards the NY-ESO-1 protein by peptide/MHC-specific antibody fragments.
European journal of immunology 2004;34(10):2919-29.
2004: Helit Cohen; Yael Danin-Poleg; Cyrille Cohen; Eli Sprecher; Saurav Guha; Yechezkel Kashi
Mono-nucleotide repeats (MNRs): a neglected polymorphism for generating high density genetic maps in silico.
Human genetics 2004;115(3):213-20.
2004: Dietmar Zehn; Cyrille Cohen; Yoram Reiter; Peter Walden
Extended presentation of specific MHC-peptide complexes by mature dendritic cells compared to other types of antigen-presenting cells.
European journal of immunology 2004;34(6):1551-60.
2004: Yoshihisa Yamano; Cyrille Cohen; Norihiro Takenouchi; Yao Jiang Karen; Utano Tomaru; Hong-Chuan Li; Yoram Reiter; Steven Jacobson
Increased expression of human T lymphocyte virus type I (HTLV-I) Tax11-19 peptide-human histocompatibility leukocyte antigen A*201 complexes on CD4+ CD25+ T Cells detected by peptide-specific, major histocompatibility complex-restricted antibodies in patients with HTLV-I-associated neurologic disease.
The Journal of experimental medicine 2004;199(10):1367-77.
2003: William E Biddison; Richard V Turner; Susan J Gagnon; Avital Lev; Cyrille Cohen; Yoram Reiter
Tax and M1 peptide/HLA-A2-specific Fabs and T cell receptors recognize nonidentical structural features on peptide/HLA-A2 complexes.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):3064-74.
2003: Cyrille Cohen; Galit Denkberg; Avital Lev; Malka Epel; Yoram Reiter
Recombinant antibodies with MHC-restricted, peptide-specific, T-cell receptor-like specificity: new tools to study antigen presentation and TCR-peptide-MHC interactions.
Journal of molecular recognition : JMR 2003;16(5):324-32.
2003: Cyrille Cohen; Galit Denkberg; Yael S Schiffenbauer; Dina Segal; Ella Trubniykov; Gideon Berke; Yoram Reiter
Simultaneous monitoring of binding to and activation of tumor-specific T lymphocytes by peptide-MHC.
Journal of immunological methods 2003;277(1-2):39-52.
2003: Cyrille Cohen; Offra Sarig; Yoshihisa Yamano; Utano Tomaru; Steven Jacobson; Yoram Reiter
Direct phenotypic analysis of human MHC class I antigen presentation: visualization, quantitation, and in situ detection of human viral epitopes using peptide-specific, MHC-restricted human recombinant antibodies.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(8):4349-61.
2003: Cyrille Cohen; Galit Denkberg; Dina Segal; Yoram Reiter
Generation of recombinant immunotoxins for specific targeting of tumor-related peptides presented by MHC molecules.
Methods in molecular biology (Clifton, N.J.) 2003;207():269-82.
2002: Cyrille Cohen; Noa Hoffmann; Marganit Farago; Hennie Hoogenboom; Lea Eisenbach; Yoram Reiter
Direct detection and quantitation of a distinct T-cell epitope derived from tumor-specific epithelial cell-associated mucin using human recombinant antibodies endowed with the antigen-specific, major histocompatibility complex-restricted specificity of T cells.
Cancer research 2002;62(20):5835-44.
2002: Galit Denkberg; Cyrille Cohen; Avital Lev; Patrick Chames; Hennie Hoogenboom; Yoram Reiter
Direct visualization of distinct T cell epitopes derived from a melanoma tumor-associated antigen by using human recombinant antibodies with MHC- restricted T cell receptor-like specificity.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(14):9421-6.
2002: Rina Ulmansky; Cyrille Cohen; Fanny Szafer; Eli Moallem; Zvi G Fridlender; Yechezkel Kashi; Yaakov Naparstek
Resistance to adjuvant arthritis is due to protective antibodies against heat shock protein surface epitopes and the induction of IL-10 secretion.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6463-9.
2002: Avital Lev; Galit Denkberg; Cyrille Cohen; Maty Tzukerman; Karl Skorecki; Patrick Chames; Hennie Hoogenboom; Yoram Reiter
Isolation and characterization of human recombinant antibodies endowed with the antigen-specific, major histocompatibility complex-restricted specificity of T cells directed toward the widely expressed tumor T-cell epitopes of the telomerase catalytic subunit.
Cancer research 2002;62(11):3184-94.
2001: Galit Denkberg; Cyrille Cohen; Yoram Reiter
Critical role for CD8 in binding of MHC tetramers to TCR: CD8 antibodies block specific binding of human tumor-specific MHC-peptide tetramers to TCR.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):270-6.
2001: Revital Niv; Cyrille Cohen; Galit Denkberg; Dina Segal; Yoram Reiter
Antibody engineering for targeted therapy of cancer: recombinant Fv-immunotoxins.
Current pharmaceutical biotechnology 2001;2(1):19-46.
2000: Galit Denkberg; Cyrille Cohen; Dina Segal; A F Kirkin; Yoram Reiter
Recombinant human single-chain MHC-peptide complexes made from E. coli By in vitro refolding: functional single-chain MHC-peptide complexes and tetramers with tumor associated antigens.
European journal of immunology 2000;30(12):3522-32.
2000: Riva Gur-Arie; Cyrille Cohen; Y Eitan; Leora A Shelef; Eric M Hallerman; Yechezkel Kashi
Simple sequence repeats in Escherichia coli: abundance, distribution, composition, and polymorphism.
Genome research 2000;10(1):62-71.