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Peter Jacobson

Research Profile

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Sweden

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Physiology

Genes & Molecular Sequences

Single Nucleotide Polymorphism

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Per-Arne Svensson; Magdalena Taube; Johanna C Andersson-Assarsson; philippe froguel; Maja Olsson; Maria J Pereira; Peter Jacobson
The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity, weight loss and resting metabolic rate.
Intawat Nookaew; Lars Sjöström; Per-Arne Svensson; Magdalena Taube; Andrew Walley; philippe froguel; Peter Jacobson; Margareta Jernås; Ingrid Larsson; Jens Nielsen; Johanna C Andersson-Assarsson; Lena M S Carlsson
Adipose tissue resting energy expenditure and expression of genes involved in mitochondrial function are higher in women than in men.
Adil Mardinoglu; Intawat Nookaew; Mathias Uhlen; Andrew J Walley; Rasmus Agren; Anna Asplund; Lena M Carlsson; philippe froguel; Peter Jacobson; Caroline Kampf; Jens Nielsen
Integration of clinical data with a genome-scale metabolic model of the human adipocyte.

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2013: Per-Arne Svensson; Magdalena Taube; Johanna C Andersson-Assarsson; philippe froguel; Maja Olsson; Maria J Pereira; Peter Jacobson
The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity, weight loss and resting metabolic rate.
Biochemical and biophysical research communications 2013;433(4):563-6.
2013: Intawat Nookaew; Lars Sjöström; Per-Arne Svensson; Magdalena Taube; Andrew Walley; philippe froguel; Peter Jacobson; Margareta Jernås; Ingrid Larsson; Jens Nielsen; Johanna C Andersson-Assarsson; Lena M S Carlsson
Adipose tissue resting energy expenditure and expression of genes involved in mitochondrial function are higher in women than in men.
The Journal of clinical endocrinology and metabolism 2013;98(2):E370-8.
2013: Adil Mardinoglu; Intawat Nookaew; Mathias Uhlen; Andrew J Walley; Rasmus Agren; Anna Asplund; Lena M Carlsson; philippe froguel; Peter Jacobson; Caroline Kampf; Jens Nielsen
Integration of clinical data with a genome-scale metabolic model of the human adipocyte.
Molecular systems biology 2013;9():649.
2012: Stefano Romeo; Kajsa Sjöholm; Lars Sjöström; Per-Arne Svensson; Peter Jacobson; Cristina Maglio; Markku Peltonen; Carlo Pirazzi; Maria Antonella Burza; Lena M S Carlsson
Cardiovascular events after bariatric surgery in obese subjects with type 2 diabetes.
Diabetes care 2012;35(12):2613-7.
2012: Maria Antonella Burza; Lena Mariana Susann Carlsson; Stefano Ginanni-Corradini; Peter Jacobson; Cristina Maglio; Rosellina Margherita Mancina; Tiziana Montalcini; Carlo Pirazzi; Martin Adiels; Marco Giorgio Baroni; Jan Borén; Kajsa Sjöholm; Lars Sjöström; Per-Arne Svensson; Stefano Romeo
PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2012;44(12):1037-41.
2012: Lena Carlsson; Peter Jacobson; Hans Lönroth; Cristina Maglio; Ingmar Näslund; Markku Peltonen; Carlo Pirazzi; Stefano Romeo; Kajsa Sjöholm; Elisabeth Sjöström; Sofie Ahlin; Åsa Anveden; Claude Bouchard; Björn Carlsson; Per-Arne Svensson; Hans Wedel; Lars Sjöström
Bariatric surgery and prevention of type 2 diabetes in Swedish obese subjects.
The New England journal of medicine 2012;367(8):695-704.
2012: Åsa Anveden; Andrew J Walley; Nasser Al-Daghri; Peter Arner; Lena M S Carlsson; philippe froguel; Peter Jacobson; Philip G McTernan; Niklas Mejhert; Vilborg Palsdottir; Kajsa Sjöholm; Lars Sjöström; Per-Arne Svensson
ITIH-5 expression in human adipose tissue is increased in obesity.
Obesity (Silver Spring, Md.) 2012;20(4):708-14.
2012: Marcel Marquez; Michel Marre; Andrew P Morris; François Pattou; Richard D Pearson; John R B Perry; Odile Poulain-Godefroy; Lars Sjöström; Sidonie Vivequin; Andrew J Walley; Loïc Yengo; Beverley Balkau; Lena M S Carlsson; Stéphane Cauchi; Guillaume Charpentier; Mario Falchi; philippe froguel; Stefan Gaget; Barbara Heude; Marlène Huyvaert; Peter Jacobson; Olivier Lantieri; Stéphane Lobbens
Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk.
Diabetes 2012;61(2):524-30.
2012: Lars Sjöström; Carl David Sjöström; Sofie Ahlin; Gerd Bergmark; Sven Dahlgren; Peter Jacobson; Hans Lönroth; Torsten Olbers; Claude Bouchard; Kristjan Karason; Markku Peltonen; Åsa Anveden; Ingmar Näslund; Jan Karlsson; Kristina Narbro; Per-Arne Svensson; Calle Bengtsson; Björn Carlsson; Hans Wedel; Anna-Karin Lindroos; Lena M S Carlsson
Bariatric surgery and long-term cardiovascular events.
JAMA : the journal of the American Medical Association 2012;307(1):56-65.
2012: Mark A Sarzynski; Lars Sjöström; Claude Bouchard; Björn Carlsson; Peter Jacobson; Tuomo Rankinen; Lena M S Carlsson
Changes in uric acid levels following bariatric surgery are not associated with SLC2A9 variants in the Swedish Obese Subjects Study.
PloS one 2012;7(12):e51658.
2012: Peter Hallersund; Peter Jacobson; Hans Lönroth; Ingmar Näslund; Torsten Olbers; Lars Sjöström; Ville Wallenius; Lena Carlsson; Lars Fändriks
Gastric bypass surgery is followed by lowered blood pressure and increased diuresis - long term results from the Swedish Obese Subjects (SOS) study.
PloS one 2012;7(11):e49696.
2012: philippe froguel; Rosa-Maria Guéant-Rodriguez; Bernard Herbeth; Peter Jacobson; Marjo-Riitta Jarvelin; Yann Labrune; Michel R Langlois; Cécile Lecoeur; Claudio Maffeis; David Meyre; Anita Morandi; Ndeye Coumba Ndiaye; Aimo Ruokonen; Gérard Siest; Lars Sjöström; Maria G Stathopoulou; Amélie Bonnefond; Leonardo Bottolo; Nabila Bouatia-Naji; Lena M S Carlsson; Aurélie Dechaume; George V Dedoussis; Joris R Delanghe; Said El Shamieh; Paul Elliott; Mario Falchi; Andrew Walley; Sophie Visvikis-Siest
A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels.
PloS one 2012;7(3):e32327.
2012: Stephen J Clark; Philippe Froguel; Peter Jacobson; Margareta Jernås; Lars Sjöström; Michel Marre; Sylvia Richardson; Lena M S Carlsson; Stéphane Cauchi; Mario Falchi; Timothy J Aitman; Hang Y Wong; Olivier Lantieri; Johanna C Andersson; Beverley Balkau; Bob Olsson; Andrew J Walley
Association of sirtuin 1 (SIRT1) gene SNPs and transcript expression levels with severe obesity.
Obesity (Silver Spring, Md.) 2012;20(1):178-85.
2012: A J Walley; M Falchi; E Petretto; C Lecoeur; L Bottolo; S Richardson; J C Andersson; Peter Jacobson; M Petteni; A Bonnefond; V Vatin; E Vaillant; M Jernas; Y S Park; L Sjostrom; T Aitman; D Balding; L M S Carlsson; P Froguel
Differential coexpression analysis of obesity-associated networks in human subcutaneous adipose tissue.
International journal of obesity (2005) 2012;36(1):137-47.
2011: Hariklia Eleftherohorinou; Julia S El-Sayed Moustafa; Johanna C Andersson-Assarsson; Alexandra I F Blakemore; Lena M S Carlsson; Lachlan Coin; philippe froguel; Peter Jacobson; Andrew J Walley; Robin G Walters; Mario Falchi
famCNV: copy number variant association for quantitative traits in families.
Bioinformatics (Oxford, England) 2011;27(13):1873-5.
2011: Mark A Sarzynski; Peter Jacobson; Tuomo Rankinen; Björn Carlsson; Lars Sjöström; Lena M S Carlsson; Claude Bouchard
Association of GWAS-based candidate genes with HDL-cholesterol levels before and after bariatric surgery in the Swedish obese subjects study.
The Journal of clinical endocrinology and metabolism 2011;96(6):E953-7.
2011: Mark A Sarzynski; Peter Jacobson; Tuomo Rankinen; B Carlsson; L Sjöström; Claude Bouchard; L M S Carlsson
Associations of markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases.
International journal of obesity (2005) 2011;35(5):676-83.
2011: Maja Olsson; Bob Olsson; Peter Jacobson; Dag Steinar Thelle; Johan Björkegren; Andrew Walley; philippe froguel; Lena Carlsson; Kajsa Sjöholm
Expression of the selenoprotein S (SELS) gene in subcutaneous adipose tissue and SELS genotype are associated with metabolic risk factors.
Metabolism: clinical and experimental 2011;60(1):114-20.
2010: Louise E Olofsson; Bob Olsson; Theodore C Lystig; Peter Jacobson; Margareta Jernås; Kajsa Sjöholm; Anders Gummesson; Lars Sjöström; Per Eriksson; Anders Hamsten; Laura P Hale; Dag Steinar Thelle; Björn Carlsson; Lena Carlsson
Preliminary report: Zn-alpha2-glycoprotein genotype and serum levels are associated with serum lipids.
Metabolism: clinical and experimental 2010;59(9):1316-8.
2010: Niels Vrang; David Meyre; Phillippe Froguel; Jacob Jelsing; Mads Tang-Christensen; Vincent Vatin; Jens D Mikkelsen; Kenneth Thirstrup; Leif K Larsen; Karina B Cullberg; Jan Fahrenkrug; Peter Jacobson; Lars Sjöström; Lena M S Carlsson; Yongjun Liu; Xiaogang Liu; Hong-Wen Deng; Philip J Larsen
The imprinted gene neuronatin is regulated by metabolic status and associated with obesity.
Obesity (Silver Spring, Md.) 2010;18(7):1289-96.
2010: R G Walters; S Jacquemont; A Valsesia; A J de Smith; D Martinet; J Andersson; M Falchi; F Chen; J Andrieux; S Lobbens; B Delobel; F Stutzmann; J S El-Sayed Moustafa; J-C Chèvre; C Lecoeur; V Vatin; S Bouquillon; Jessica Louise Buxton; O Boute; M Holder-Espinasse; J-M Cuisset; M-P Lemaitre; A-E Ambresin; A Brioschi; M Gaillard; V Giusti; F Fellmann; A Ferrarini; Nouchine Hadjikhani; D Campion; A Guilmatre; A Goldenberg; N Calmels; J-L Mandel; C Le Caignec; A David; B Isidor; M-P Cordier; S Dupuis-Girod; A Labalme; D Sanlaville; M Béri-Dexheimer; P Jonveaux; B Leheup; K Ounap; E G Bochukova; E Henning; J Keogh; R J Ellis; K D Macdermot; M M van Haelst; C Vincent-Delorme; G Plessis; R Touraine; A Philippe; V Malan; M Mathieu-Dramard; J Chiesa; B Blaumeiser; R F Kooy; R Caiazzo; M Pigeyre; B Balkau; R Sladek; S Bergmann; V Mooser; D Waterworth; A Reymond; P Vollenweider; G Waeber; A Kurg; P Palta; T Esko; A Metspalu; M Nelis; P Elliott; A-L Hartikainen; M I McCarthy; L Peltonen; L Carlsson; Peter Jacobson; L Sjöström; N Huang; M E Hurles; S O'Rahilly; I S Farooqi; K Männik; M-R Jarvelin; F Pattou; D Meyre; A J Walley; L J M Coin; A I F Blakemore; P Froguel; Jacques Beckmann
A new highly penetrant form of obesity due to deletions on chromosome 16p11.2.
Nature 2010;463(7281):671-5.
2009: Atsuhito Saiki; Maja Olsson; Margareta Jernås; Anders Gummesson; Philip G McTernan; Johanna Andersson; Peter Jacobson; Kajsa Sjöholm; Bob Olsson; Shigeo Yamamura; Andrew Walley; philippe froguel; Björn Carlsson; Lars Sjöström; Per-Arne Svensson; Lena Carlsson
Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss.
The Journal of clinical endocrinology and metabolism 2009;94(10):3987-94.
2009: Lars Sjöström; Anders Gummesson; Carl David Sjöström; Kristina Narbro; Markku Peltonen; Hans Wedel; Calle Bengtsson; Claude Bouchard; Björn Carlsson; Sven Dahlgren; Peter Jacobson; Kristjan Karason; Jan Karlsson; Bo Larsson; Anna Karin Lindroos; Hans Lönroth; Ingmar Näslund; Torsten Olbers; Kaj Stenlöf; Jarl S Torgerson; Lena Carlsson
Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial.
The lancet oncology 2009;10(7):653-62.
2009: Margareta Jernås; Bob Olsson; Peter Arner; Peter Jacobson; Lars Sjöström; Andrew Walley; philippe froguel; Philip G McTernan; Johan Hoffstedt; Lena Carlsson
Regulation of carboxylesterase 1 (CES1) in human adipose tissue.
Biochemical and biophysical research communications 2009;383(1):63-7.
2009: Lena Carlsson; Peter Jacobson; Andrew Walley; philippe froguel; Lars Sjöström; Per-Arne Svensson; Kajsa Sjöholm
ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease.
Biochemical and biophysical research communications 2009;382(2):309-14.
2008: Michael Benzinou; John W M Creemers; Helene Choquet; Stephane Lobbens; Christian Dina; Emmanuelle Durand; Audrey Guerardel; Philippe Boutin; Beatrice Jouret; Barbara Heude; Beverley Balkau; Jean Tichet; Michel Marre; Natascha Potoczna; Fritz Horber; Catherine Le Stunff; Sebastien czernichow; Annelli Sandbaek; torsten lauritzen; Knut Borch-Johnsen; Gitte Andersen; Wieland Kiess; Antje Körner; Peter Kovacs; Peter Jacobson; Lena Carlsson; Andrew J Walley; Torben Jørgensen; Torben Hansen; Oluf Pedersen; David Meyre; philippe froguel
Common nonsynonymous variants in PCSK1 confer risk of obesity.
Nature genetics 2008;40(8):943-5.
2008: Jens Jordan; F L Greenway; L A Leiter; Z Li; Peter Jacobson; K Murphy; J Hill; L Kler; R P Aftring
Stimulation of cholecystokinin-A receptors with GI181771X does not cause weight loss in overweight or obese patients.
Clinical pharmacology and therapeutics 2008;83(2):281-7.
2007: Lars Sjöström; Kristina Narbro; Carl David Sjöström; Kristjan Karason; Bo Larsson; Hans Wedel; Theodore C Lystig; Marianne Sullivan; Claude Bouchard; Björn Carlsson; Calle Bengtsson; Sven Dahlgren; Anders Gummesson; Peter Jacobson; Jan Karlsson; Anna Karin Lindroos; Hans Lönroth; Ingmar Näslund; Torsten Olbers; Kaj Stenlöf; Jarl S Torgerson; Göran Agren; Lena Carlsson
Effects of bariatric surgery on mortality in Swedish obese subjects.
The New England journal of medicine 2007;357(8):741-52.
2007: Christian Dina; David Meyre; Sophie Gallina; Emmanuelle Durand; Antje Körner; Peter Jacobson; Lena Carlsson; Wieland Kiess; Vincent Vatin; Cécile Lecoeur; Jérôme Delplanque; Emmanuel Vaillant; François Pattou; Juan Ruiz; Jacques Weill; Claire Levy-Marchal; Fritz F Horber; Natascha Potoczna; Serge Hercberg; Catherine Le Stunff; Pierre Bougnères; Peter Kovacs; Michel Marre; Beverley Balkau; Stéphane Cauchi; Jean-Claude Chèvre; philippe froguel
Variation in FTO contributes to childhood obesity and severe adult obesity.
Nature genetics 2007;39(6):724-6.
2007: Peter Jacobson; Jarl S Torgerson; Lars Sjöström; Claude Bouchard
Spouse resemblance in body mass index: effects on adult obesity prevalence in the offspring generation.
American journal of epidemiology 2007;165(1):101-8.
2006: Peter Jacobson; Tuomo Rankinen; Angelo Tremblay; Louis Pérusse; Yvon C Chagnon; Claude Bouchard
Resting metabolic rate and respiratory quotient: results from a genome-wide scan in the Quebec Family Study.
The American journal of clinical nutrition 2006;84(6):1527-33.
2003: Olavi Ukkola; Eric Ravussin; Peter Jacobson; Lars Sjöström; Claude Bouchard
Mutations in the adiponectin gene in lean and obese subjects from the Swedish obese subjects cohort.
Metabolism: clinical and experimental 2003;52(7):881-4.
2002: Peter Jacobson; Olavi Ukkola; Tuomo Rankinen; Eric Snyder; Arthur S Leon; Dabeeru C Rao; James Skinner; Jack H Wilmore; Lars Lönn; George S Cowan; Lars Sjöström; Claude Bouchard
Melanocortin 4 receptor sequence variations are seldom a cause of human obesity: the Swedish Obese Subjects, the HERITAGE Family Study, and a Memphis cohort.
The Journal of clinical endocrinology and metabolism 2002;87(10):4442-6.
2002: Olavi Ukkola; Eric Ravussin; Peter Jacobson; Louis Pérusse; Tuomo Rankinen; Matthias H Tschöp; Mark L Heiman; Arthur S Leon; Dabeeru C Rao; James Skinner; Jack H Wilmore; Lars Sjöström; Claude Bouchard
Role of ghrelin polymorphisms in obesity based on three different studies.
Obesity research 2002;10(8):782-91.
2001: Olavi Ukkola; Eric Ravussin; Peter Jacobson; Eric Snyder; M Chagnon; Lars Sjöström; Claude Bouchard
Mutations in the preproghrelin/ghrelin gene associated with obesity in humans.
The Journal of clinical endocrinology and metabolism 2001;86(8):3996-9.