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Daniel Jun

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O Soukup; Gunnar Tobin; Daniel Jun; Kamil Kuca
The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors.
O Soukup; V Tambor; Daniel Jun; Z Kristofikova; D Ripova; Kamil Kuca
The interaction of standard oxime reactivators with hemicholinium-3 sensitive choline carriers.
Marie Trovaslet-Leroy; Laurent Verdier; Ladislav Novotny; Frédérique Renault; Daniel Rochu; Xavier Brazzolotto; Marie-Thérèse Froment; Emilie Gillon; Daniel Jun; Mélanie Loiodice; Patrick Masson; Jan Misik; Lucie Musilova; Florian Nachon
Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents.

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All Publications

2013: O Soukup; Gunnar Tobin; Daniel Jun; Kamil Kuca
The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors.
Archives of toxicology 2013;87(4):711-9.
2012: O Soukup; V Tambor; Daniel Jun; Z Kristofikova; D Ripova; Kamil Kuca
The interaction of standard oxime reactivators with hemicholinium-3 sensitive choline carriers.
Toxicology letters 2012;212(3):315-9.
2011: Marie Trovaslet-Leroy; Laurent Verdier; Ladislav Novotny; Frédérique Renault; Daniel Rochu; Xavier Brazzolotto; Marie-Thérèse Froment; Emilie Gillon; Daniel Jun; Mélanie Loiodice; Patrick Masson; Jan Misik; Lucie Musilova; Florian Nachon
Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents.
Toxicology letters 2011;206(1):14-23.
2011: O Soukup; A Adem; L Bratova; Josef Fusek; Daniel Jun; Kamil Kuca; U K Kumar; Jan Proska; Gunnar Tobin
The effect of oxime reactivators on muscarinic receptors: functional and binding examinations.
Environmental toxicology and pharmacology 2011;31(3):364-70.
2011: Daniel Jun; Kamil Musilek; Lucie Musilova; Kamil Kuca
In vitro ability of currently available oximes to reactivate organophosphate pesticide-inhibited human acetylcholinesterase and butyrylcholinesterase.
International journal of molecular sciences 2011;12(3):2077-87.
2011: O Soukup; Josef Fusek; Daniel Jun; M Kaniaková; J Krůšek; K Kuča; U K Kumar; M Oz; Gunnar Tobin
Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors.
Physiological research / Academia Scientiarum Bohemoslovaca 2011;60(4):679-86.
2010: Jiri Bajgar; Petr Hajek; Jana Karasova Zdarova; Jirí Kassa; Antonin Paseka; Dasa Slizova; Otakar Krs; Kamil Kuca; Daniel Jun; Josef Fusek; Lukas Capek
A comparison of tabun-inhibited rat brain acetylcholinesterase reactivation by three oximes (HI-6, obidoxime, and K048) in vivo detected by biochemical and histochemical techniques.
Journal of enzyme inhibition and medicinal chemistry 2010;25(6):790-7.
2010: Jiří Wiesner; Zdeněk Kříž; Kamil Kuča; Daniel Jun; Jaroslav Koča
Influence of the acetylcholinesterase active site protonation on omega loop and active site dynamics.
Journal of biomolecular structure & dynamics 2010;28(3):393-403.
2010: O Soukup; Z Kristofikova; Jan Proska; Gunnar Tobin; Jirí Patocka; Jan Marek; Daniel Jun; Josef Fusek; D Ripova; Kamil Kuca
Novel acetylcholinesterase reactivator K112 and its cholinergic properties.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2010;64(8):541-5.
2010: Daniel Jun; Lucie Musilová; Marek Link; Mélanie Loiodice; Florian Nachon; Daniel Rochu; Frédérique Renault; Patrick Masson
Preparation and characterization of methoxy polyethylene glycol-conjugated phosphotriesterase as a potential catalytic bioscavenger against organophosphate poisoning.
Chemico-biological interactions 2010;187(1-3):380-3.
2010: Zrinka Kovarik; Maja Katalinić; Dr Goran Sinko; Jiri Binder; Ondrej Holas; Young-Sik Jung; Lucie Musilova; Daniel Jun; Kamil Kuca
Pseudo-catalytic scavenging: searching for a suitable reactivator of phosphorylated butyrylcholinesterase.
Chemico-biological interactions 2010;187(1-3):167-71.
2010: Daniel Jun; Petr Stodulka; Kamil Kuca; Bohuslav Dolezal
High-performance liquid chromatography analysis of by-products and intermediates arising during the synthesis of the acetylcholinesterase reactivator HI-6.
Journal of chromatographic science 2010;48(8):694-6.
2010: Ondrej Soukup; Gunnar Tobin; Uday Killi Kumar; Daniel Jun; Josef Fusek; Kamil Kuca
Characterization of the anticholinergic properties of obidoxime; functional examinations of the rat atria and the urinary bladder.
Toxicology mechanisms and methods 2010;20(7):428-33.
2010: Kamil Kuca; Kamil Musilek; Daniel Jun; Miroslav Pohanka; Kallol Kumar Ghosh; Martina Hrabinova
Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase.
Journal of enzyme inhibition and medicinal chemistry 2010;25(4):509-12.
2010: Kamil Kuca; Kamil Musilek; Kyung-Ae Oh; Jaroslav Pejchal; Miroslav Pohanka; Ondrej Soukup; Garp Yeol Yang; Jiri Cabal; Daniel Jun; Young-Sik Jung
Reactivation of VX-inhibited AChE by novel oximes having two oxygen atoms in the linker.
Environmental toxicology and pharmacology 2010;30(1):85-7.
2010: Jirí Wiesner; Zdenek Kríz; Kamil Kuca; Daniel Jun; Jaroslav Koca
Why acetylcholinesterase reactivators do not work in butyrylcholinesterase.
Journal of enzyme inhibition and medicinal chemistry 2010;25(3):318-22.
2010: Vlastimil Dohnal; Alena Jezkova; Lucie Pavlikova; Kamil Musilek; Daniel Jun; Kamil Kuca
Fluctuation in the ergosterol and deoxynivalenol content in barley and malt during malting process.
Analytical and bioanalytical chemistry 2010;397(1):109-14.
2010: Vit Koleckar; Lubomír Opletal; Katerina Macakova; Ludek Jahodar; Daniel Jun; Jiri Kunes; Kamil Kuca
New antioxidant flavonoid isolated from Leuzea carthamoides.
Journal of enzyme inhibition and medicinal chemistry 2010;25(1):143-5.
2010: Daniel Jun; Lucie Musilova; Miroslav Pohanka; Young-Sik Jung; Pavel Bostik; Kamil Kuca
Reactivation of human acetylcholinesterase and butyrylcholinesterase inhibited by leptophos-oxon with different oxime reactivators in vitro.
International journal of molecular sciences 2010;11(8):2856-63.
2010: Jan Korabecny; Kamil Musilek; Ondrej Holas; Eugenie Nepovimova; Daniel Jun; Filip Zemek; Veronika Opletalova; Jiri Patocka; Vlastimil Dohnal; Florian Nachon; Jana Hroudova; Zdenek Fisar; Kamil Kuca
Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment.
Molecules (Basel, Switzerland) 2010;15(12):8804-12.
2010: O Soukup; Gunnar Tobin; U K Kumar; J Binder; J Proska; Daniel Jun; Josef Fusek; Kamil Kuca
Interaction of nerve agent antidotes with cholinergic systems.
Current medicinal chemistry 2010;17(16):1708-18.
2009: Jana Zdarova Karasova; Jiri Bajgar; Daniel Jun; Ruzena Pavlikova; Kamil Kuca
Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX.
Neurotoxicity research 2009;16(4):356-60.
2009: Ondrej Soukup; Jan Proska; Jiri Binder; Jana Zdarova Karasova; Gunnar Tobin; Daniel Jun; Jan Marek; Kamil Musílek; Josef Fusek; Kamil Kuca
Methylacridinium and its cholinergic properties.
Neurotoxicity research 2009;16(4):372-7.
2009: Kamil Kuca; Jiri Cabal; Yung Sik Jung; Kamil Musilek; Ondrej Soukup; Daniel Jun; Miroslav Pohanka; Lucie Musilova; Jana Karasová; Ladislav Novotný; Martina Hrabinova
Reactivation of human brain homogenate cholinesterases inhibited by Tabun using newly developed oximes K117 and K127.
Basic & clinical pharmacology & toxicology 2009;105(3):207-10.
2009: Alena Veinlichova; Petra Jancova; Michal Siller; Pavel Anzenbacher; Kamil Kuca; Daniel Jun; Josef Fusek; Eva Anzenbacherova
Effect of acetylcholinesterase oxime-type reactivators K-48 and HI-6 on human liver microsomal cytochromes P450 in vitro.
Chemico-biological interactions 2009;180(3):449-53.
2009: Lucie Musilova; Kamil Kuca; Young-Sik Jung; Daniel Jun
In vitro oxime-assisted reactivation of paraoxon-inhibited human acetylcholinesterase and butyrylcholinesterase.
Clinical toxicology (Philadelphia, Pa.) 2009;47(6):545-50.
2009: Miroslav Pohanka; Daniel Jun; Kamil Kuca
In vitro reactivation of trichlorfon-inhibited butyrylcholinesterase using HI-6, obidoxime, pralidoxime and K048.
Journal of enzyme inhibition and medicinal chemistry 2009;24(3):680-3.
2009: Kamil Kuca; Lucie Musilova; Jiri Palecek; Vladimir Cirkva; Martin Paar; Kamil Musilek; Martina Hrabinova; Miroslav Pohanka; Jana Zdarova Karasova; Daniel Jun
Novel bisquaternary oximes--reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon.
Molecules (Basel, Switzerland) 2009;14(12):4915-21.
2009: Jiri Bajgar; Josef Fusek; Jiri Kassa; Kamil Kuca; Daniel Jun
Chemical aspects of pharmacological prophylaxis against nerve agent poisoning.
Current medicinal chemistry 2009;16(23):2977-86.
2009: Lubica Cibickova; Radomir Hyspler; Hyspler Radomir; Stanislav Micuda; Micuda Stanislav; Norbert Cibicek; Cibicek Norbert; Helena Zivna; Zivna Helena; Daniel Jun; Jun Daniel; Alena Ticha; Ticha Alena; Eva Brcakova; Brcakova Eva; Vladimir Palicka; Palicka Vladimir
The influence of simvastatin, atorvastatin and high-cholesterol diet on acetylcholinesterase activity, amyloid beta and cholesterol synthesis in rat brain.
Steroids 2009;74(1):13-9.
2008: Miroslav Pohanka; Daniel Jun; Kamil Kuca
Photometric microplate assay for estimation of the efficacy of paraoxon-inhibited acetylcholinesterase reactivation.
Journal of enzyme inhibition and medicinal chemistry 2008;23(6):781-4.
2008: Sarka Vesela; Kamil Kuca; Daniel Jun
Efficacy and dosing of antidotes applied to Daphnia intoxicated by nerve agent tabun.
Environmental toxicology and pharmacology 2008;26(3):283-9.
2008: Miroslav Pohanka; Daniel Jun; Kamil Kuca
Improvement of acetylcholinesterase-based assay for organophosphates in way of identification by reactivators.
Talanta 2008;77(1):451-4.
2008: Ondrej Soukup; Miroslav Pohanka; Gunnar Tobin; Daniel Jun; Josef Fusek; Kamil Musilek; Jan Marek; Jirí Kassa; Kamil Kuca
The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder.
Neuro endocrinology letters 2008;29(5):759-62.
2008: Daniel Jun; L Musilova; Kamil Kuca; J Kassa; Jiri Bajgar
Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro.
Chemico-biological interactions 2008;175(1-3):421-4.
2008: Jiri Bajgar; Josef Fusek; Jirí Kassa; Daniel Jun; Kamil Kuca; Petr Hajek
An attempt to assess functionally minimal acetylcholinesterase activity necessary for survival of rats intoxicated with nerve agents.
Chemico-biological interactions 2008;175(1-3):281-5.
2008: Kyung-Ae Oh; No-Joong Park; No-Sang Park; Kamil Kuca; Daniel Jun; Young-Sik Jung
Reactivation of DFP- and paraoxon-inhibited acetylcholinesterases by pyridinium oximes.
Chemico-biological interactions 2008;175(1-3):365-7.
2008: Jirí Kassa; Daniel Jun; Jana Karasova; Jiri Bajgar; Kamil Kuca
A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in soman, cyclosarin and tabun-poisoned rats.
Chemico-biological interactions 2008;175(1-3):425-7.
2008: Kamil Musilek; Jiri Kucera; Daniel Jun; Vlastimil Dohnal; Veronika Opletalova; Kamil Kuca
Monoquaternary pyridinium salts with modified side chain-synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase.
Bioorganic & medicinal chemistry 2008;16(17):8218-23.
2008: Jaroslav Pejchal; Jan Osterreicher; Kamil Kuca; Daniel Jun; Jiri Bajgar; Jiri Kassa
The influence of acetylcholinesterase reactivators on selected hepatic functions in rats.
Basic & clinical pharmacology & toxicology 2008;103(2):119-23.
2008: Frantisek Cervenka; Vit Koleckar; Zuzana Rehakova; Ludek Jahodar; Jiri Kunes; Lubomír Opletal; Radomir Hyspler; Daniel Jun; Kamil Kuca
Evaluation of natural substances from Evolvulus alsinoides L. with the purpose of determining their antioxidant potency.
Journal of enzyme inhibition and medicinal chemistry 2008;23(4):574-8.
2008: Sarka Vesela; Kamil Kuca; Daniel Jun
Daphnia intoxicated by nerve agent tabun can be treated using human antidotes.
Environmental toxicology and pharmacology 2008;25(3):329-33.
2008: Vit Koleckar; Katerina Kubikova; Zuzana Rehakova; Kamil Kuca; Daniel Jun; Ludek Jahodar; Lubomír Opletal
Condensed and hydrolysable tannins as antioxidants influencing the health.
Mini reviews in medicinal chemistry 2008;8(5):436-47.
2008: Jiri Patocka; Daniel Jun; Kamil Kuca
Possible role of hydroxylated metabolites of tacrine in drug toxicity and therapy of Alzheimer's disease.
Current drug metabolism 2008;9(4):332-5.
2008: Kamil Musilek; Josef Jampilek; Jiri Dohnal; Daniel Jun; Frank Gunn-Moore; Martin Dolezal; Kamil Kuca
RP-HPLC determination of the lipophilicity of bispyridinium reactivators of acetylcholinesterase bearing a but-2-ene connecting linker.
Analytical and bioanalytical chemistry 2008;391(1):367-72.
2008: Daniel Jun; Petr Stodulka; Kamil Kuca; Vit Koleckar; Bohuslav Dolezal; Peter Simon; Miroslav Veverka
TLC analysis of intermediates arising during the preparation of oxime HI-6 dimethanesulfonate.
Journal of chromatographic science 2008;46(4):316-9.
2008: Vit Koleckar; Lubomír Opletal; Eliska Brojerova; Zuzana Rehakova; Frantisek Cervenka; Katerina Kubikova; Kamil Kuca; Daniel Jun; Miroslav Polasek; Jiri Kunes; Ludek Jahodar
Evaluation of natural antioxidants of Leuzea carthamoides as a result of a screening study of 88 plant extracts from the European Asteraceae and Cichoriaceae.
Journal of enzyme inhibition and medicinal chemistry 2008;23(2):218-24.
2008: Petr Stodulka; Vit Koleckar; Daniel Jun; Kamil Kuca; Zuzana Rehakova; Katerina Kubikova; Ludek Jahodar; Jiri Kunes; Lubomír Opletal
High-performance liquid chromatography analysis of four Leuzea carthamoides flavonoids.
Journal of chromatographic science 2008;46(2):162-4.
2008: Kamil Musilek; Ondrej Holas; Kamil Kuca; Daniel Jun; Vlastimil Dohnal; Veronika Opletalova; Martin Dolezal
Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase.
Journal of enzyme inhibition and medicinal chemistry 2008;23(1):70-6.
2008: Kamil Kuca; Jiri Cabal; Daniel Jun; Vit Koleckar
In Vitro Comparison of Two Most Promising H-Oximes (HI-6 and HLö-7) and Currently Commercially Available Reactivators Pralidoxime and Obidoxime in Reactivation of Cyclosarin-Inhibited Human Cholinesterases.
Toxicology mechanisms and methods 2008;18(4):329-33.
2008: Zuzana Rehakova; Vit Koleckar; F Cervenka; L Jahodar; L Saso; Lubomír Opletal; Daniel Jun; Kamil Kuca
DPPH Radical Scavenging Activity of Several Naturally Occurring Coumarins and Their Synthesized Analogs Measured by the SIA Method.
Toxicology mechanisms and methods 2008;18(5):413-8.
2008: Miroslav Pohanka; Daniel Jun; Huba Kalasz; Kamil Kuca
Cholinesterase biosensor construction - a review.
Protein and peptide letters 2008;15(8):795-8.
2008: Vlastimil Dohnal; Alena Jezkova; Daniel Jun; Kamil Kuca
Metabolic pathways of T-2 toxin.
Current drug metabolism 2008;9(1):77-82.
2008: Vit Koleckar; Eliska Brojerova; Zuzana Rehakova; Katerina Kubikova; Frantisek Cervenka; Kamil Kuca; Daniel Jun; Miloslav Hronek; Veronika Opletalova; Lubomír Opletal
In vitro antiplatelet activity of flavonoids from Leuzea carthamoides.
Drug and chemical toxicology 2008;31(1):27-35.
2008: Daniel Jun; Kamil Kuca; Jan Picha; Vit Koleckar; Jan Marek
Potency of novel oximes to reactivate sarin inhibited human cholinesterases.
Drug and chemical toxicology 2008;31(1):1-9.
2007: Jiri Bajgar; Kamil Kuca; Daniel Jun; Lucie Bartosova; Josef Fusek
Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates/nerve agents.
Current drug metabolism 2007;8(8):803-9.
2007: Kamil Musilek; Daniel Jun; Jiri Cabal; Jirí Kassa; Frank Gunn-Moore; Kamil Kuca
Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203).
Journal of medicinal chemistry 2007;50(22):5514-8.
2007: Jirí Kassa; Daniel Jun; Kamil Kuca; Jiri Bajgar
Comparison of reactivating and therapeutic efficacy of two salts of the oxime HI-6 against tabun, soman and cyclosarin in rats.
Basic & clinical pharmacology & toxicology 2007;101(5):328-32.
2007: Kamil Musilek; Ondrej Holas; Daniel Jun; Vlastimil Dohnal; Frank Gunn-Moore; Veronika Opletalova; Martin Dolezal; Kamil Kuca
Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase.
Bioorganic & medicinal chemistry 2007;15(21):6733-41.
2007: Jiri Bajgar; Kamil Kuca; Josef Fusek; Jana Karasova; Jirí Kassa; Jiri Cabal; Daniel Jun; Vladimir Blaha
Inhibition of blood cholinesterases following intoxication with VX and its derivatives.
Journal of applied toxicology : JAT 2007;27(5):458-63.
2007: Kamil Musilek; Ondrej Holas; Kamil Kuca; Daniel Jun; Vlastimil Dohnal; Martin Dolezal
Synthesis of a novel series of non-symmetrical bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.
Journal of enzyme inhibition and medicinal chemistry 2007;22(4):425-32.
2007: Jirí Wiesner; Zdenek Kriz; Kamil Kuca; Daniel Jun; Jaroslav Koca
Acetylcholinesterases--the structural similarities and differences.
Journal of enzyme inhibition and medicinal chemistry 2007;22(4):417-24.
2007: Vlastimil Dohnal; A Jezková; Kamil Kuca; Daniel Jun
[T-2 toxin: occurrence and detection].
Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti 2007;56(4):174-7.
2007: Kamil Kuca; Daniel Jun; Jiri Cabal; Lucie Musilova
Bisquaternary oximes as reactivators of tabun-inhibited human brain cholinesterases: an in vitro study.
Basic & clinical pharmacology & toxicology 2007;101(1):25-8.
2007: Jirí Kassa; Daniel Jun; Kamil Kuca
A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun-poisoned rats.
Journal of enzyme inhibition and medicinal chemistry 2007;22(3):297-300.
2007: Kamil Kuca; Jiri Cabal; Daniel Jun; Martina Hrabinova
Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin.
Clinical toxicology (Philadelphia, Pa.) 2007;45(5):512-5.
2007: Kamil Musilek; Ondrej Holas; Kamil Kuca; Daniel Jun; Vlastimil Dohnal; Veronika Opletalova; Martin Dolezal
Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker--synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.
Bioorganic & medicinal chemistry letters 2007;17(11):3172-6.
2007: Jiri Bajgar; Josef Fusek; Kamil Kuca; Lucie Bartosova; Daniel Jun
Treatment of organophosphate intoxication using cholinesterase reactivators: facts and fiction.
Mini reviews in medicinal chemistry 2007;7(5):461-6.
2007: V Koleckár; E Brojerová; Lubomír Opletal; Daniel Jun; Kamil Kuca
[Antioxidants, free radicals, mechanism of action and application in the therapy of the sulfur mustard caused injury].
Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti 2007;56(2):73-6.
2007: Kamil Kuca; Jiri Cabal; Daniel Jun; Kamil Musilek
In vitro reactivation potency of acetylcholinesterase reactivators--K074 and K075--to reactivate tabun-inhibited human brain cholinesterases.
Neurotoxicity research 2007;11(2):101-6.
2007: Jiri Bajgar; Petr Hajek; Dasa Slizova; Otakar Krs; Josef Fusek; Kamil Kuca; Daniel Jun; Lucie Bartosova; Vladimir Blaha
Changes of acetylcholinesterase activity in different rat brain areas following intoxication with nerve agents: biochemical and histochemical study.
Chemico-biological interactions 2007;165(1):14-21.
2007: Miroslav Pohanka; Kamil Kuca; Daniel Jun
Amperometric biosensor for pesticide methamidophos assay.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2007;50(4):239-41.
2007: Kamil Musílek; Kamil Kuca; Daniel Jun
Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX).
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2007;50(3):203-6.
2007: Kamil Kuca; Daniel Jun; Jiri Bajgar
Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications.
Current pharmaceutical design 2007;13(33):3445-52.
2007: Kamil Kuca; Jan Marek; Petr Stodulka; Kamil Musilek; Petra Hanusova; Martina Hrabinova; Daniel Jun
Preparation of benzalkonium salts differing in the length of a side alkyl chain.
Molecules (Basel, Switzerland) 2007;12(10):2341-7.
2007: Kamil Kuca; Kamil Musilek; Martin Paar; Daniel Jun; Petr Stodulka; Martina Hrabinova; Jan Marek
Targeted synthesis of 1-(4-hydroxyiminomethylpyridinium)-3-pyridiniumpropane dibromide--a new nerve agent reactivator.
Molecules (Basel, Switzerland) 2007;12(8):1964-72.
2007: Kamil Musilek; Kamil Kuca; Vlastimil Dohnal; Daniel Jun; Jan Marek; Vit Koleckar
Two step synthesis of a non-symmetric acetylcholinesterase reactivator.
Molecules (Basel, Switzerland) 2007;12(8):1755-61.
2007: Jiri Bajgar; Lucie Bartosova; Kamil Kuca; Daniel Jun; Josef Fusek
Changes of cholinesterase activities in the rat blood and brain after sarin intoxication pretreated with butyrylcholinesterase.
Drug and chemical toxicology 2007;30(4):351-9.
2007: Miroslav Pohanka; Daniel Jun; Kamil Kuca
Mycotoxin assays using biosensor technology: a review.
Drug and chemical toxicology 2007;30(3):253-61.
2007: Kamil Kuca; Daniel Jun; Jiri Bajgar
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro.
Drug and chemical toxicology 2007;30(1):31-40.
2007: L Cibicková; Vladimir Palicka; N Cibicek; E Cermáková; S Micuda; L Bartosová; Daniel Jun
Differential effects of statins and alendronate on cholinesterases in serum and brain of rats.
Physiological research / Academia Scientiarum Bohemoslovaca 2007;56(6):765-70.
2006: Kamil Kuca; Daniel Jun
Reactivation of sarin-inhibited pig brain acetylcholinesterase using oxime antidotes.
Journal of medical toxicology : official journal of the American College of Medical Toxicology 2006;2(4):141-6.
2006: Jiri Bajgar; Lucie Bartosova; Josef Fusek; Daniel Jun; Kamil Kuca
Equine butyrylcholinesterase protects rats against inhalation exposure to sublethal sarin concentrations.
Arhiv za higijenu rada i toksikologiju 2006;57(4):391-5.
2006: Veronika Racakova; Martina Hrabinova; Daniel Jun; Kamil Kuca
Substituted monoquaternary oximes as reactivators of cyclosarin--and chlorpyrifos--inhibited acetylcholinesterase.
Arhiv za higijenu rada i toksikologiju 2006;57(4):387-90.
2006: Kamil Kuca; Jiri Cabal; Daniel Jun; Jiri Bajgar; Martina Hrabinova
Potency of new structurally different oximes to reactivate cyclosarin-inhibited human brain acetylcholinesterases.
Journal of enzyme inhibition and medicinal chemistry 2006;21(6):663-6.
2006: Ana Lucić Vrdoljak; Maja Calić; Bozica Radić; Suzana Berend; Daniel Jun; Kamil Kuca; Zrinka Kovarik
Pretreatment with pyridinium oximes improves antidotal therapy against tabun poisoning.
Toxicology 2006;228(1):41-50.
2006: Kamil Musilek; Ondrej Holas; Kamil Kuca; Daniel Jun; Vlastimil Dohnal; Martin Dolezal
Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.
Bioorganic & medicinal chemistry letters 2006;16(21):5673-6.
2006: Martina Hrabinova; Kamil Musilek; Daniel Jun; Kamil Kuca
New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin.
Journal of enzyme inhibition and medicinal chemistry 2006;21(5):515-9.
2006: Kyung-Ae Oh; Garp Yeol Yang; Daniel Jun; Kamil Kuca; Young-Sik Jung
Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)n OCH2 linkers between pyridinium rings and their reactivity against VX.
Bioorganic & medicinal chemistry letters 2006;16(18):4852-5.
2006: Jirí Kassa; Daniel Jun; Kamil Kuca
The reactivating and therapeutic efficacy of oximes to counteract Russian VX poisonings.
International journal of toxicology 2006;25(5):397-401.
2006: Jiri Bajgar; Josef Fusek; Lucie Bartosova; Daniel Jun; Kamil Kuca
Evaluation of reactivation test in anaesthetized dogs with experimental intoxication with nerve agents.
Journal of applied toxicology : JAT 2006;26(5):439-43.
2006: Kamil Kuca; Jiri Cabal; Jirí Kassa; Daniel Jun; Martina Hrabinova
In vitro potency of H oximes (HI-6, HLö-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase.
Journal of toxicology and environmental health. Part A 2006;69(15):1431-40.
2006: Lucie Bartosova; Kamil Kuca; Gabriela Kunesova; Daniel Jun
The acute toxicity of acetylcholinesterase reactivators in mice in relation to their structure.
Neurotoxicity research 2006;9(4):291-6.
2006: K Musílek; Kamil Kuca; Daniel Jun; Vlastimil Dohnal; T H Kim; Y S Jung; Martin Dolezal
[Synthesis of reactivators of phosphorylated acetylcholinesterase of bis-pyridiniumdialdoxime type with a 3-oxapentane connecting chain and their testing in vitro on a model of the enzyme inhibited by chlorpyrifos and methylchlorpyrifos].
Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti 2006;55(3):115-9.
2006: Daniel Jun; Kamil Kuca; Miloslav Hronek; Lubomír Opletal
Effect of some acetylcholinesterase reactivators on human platelet aggregation in vitro.
Journal of applied toxicology : JAT 2006;26(3):258-61.
2006: Kamil Kuca; Daniel Jun; Jiri Cabal; Martina Hrabinova; Lucie Bartosova; Veronika Opletalova
Russian VX: inhibition and reactivation of acetylcholinesterase compared with VX agent.
Basic & clinical pharmacology & toxicology 2006;98(4):389-94.
2006: Maja Calić; Ana Lucic Vrdoljak; Bozica Radić; Dubravko Jelić; Daniel Jun; Kamil Kuca; Zrinka Kovarik
In vitro and in vivo evaluation of pyridinium oximes: mode of interaction with acetylcholinesterase, effect on tabun- and soman-poisoned mice and their cytotoxicity.
Toxicology 2006;219(1-3):85-96.
2006: Kamil Musilek; Kamil Kuca; Daniel Jun; Vlastimil Dohnal; Martin Dolezal
Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase.
Bioorganic & medicinal chemistry letters 2006;16(3):622-7.
2006: Kamil Kuca; Jan Pícha; Daniel Jun
Reactivation potency of new group of acetylcholinesterase reactivators and their comparison with currently available oximes.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2006;49(4):233-5.
2006: Kamil Kuca; Jiri Cabal; Daniel Jun; Martina Hrabinova
In vitro evaluation of acetylcholinesterase reactivators as potential antidotes against tabun nerve agent poisonings.
Drug and chemical toxicology 2006;29(4):443-9.
2005: Daniel Jun; Kamil Kuca; Jiri Cabal; Lucie Bartosova; Gabriela Kunesova; Jirí Kassa
Comparison of ability of some oximes to reactivate sarin-inhibited brain acetylcholinesterase from different species.
Chemico-biological interactions 2005;157-158():385-7.
2005: Kamil Kuca; Lucie Bartosova; Jirí Kassa; Jiri Cabal; Jiri Bajgar; Gabriela Kunesova; Daniel Jun
Comparison of the potency of newly developed and currently available oximes to reactivate nerve agent-inhibited acetylcholinesterase in vitro and in vivo.
Chemico-biological interactions 2005;157-158():367-8.
2005: Kamil Kuca; Jiri Cabal; Daniel Jun; Jirí Kassa; Lucie Bartosová; Gabriela Kunesová; Vlastimil Dohnal
Strategy for the development of new acetylcholinesterase reactivators - antidotes used for treatment of nerve agent poisonings.
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2005;149(2):429-31.
2005: Vlastimil Dohnal; Kamil Kuca; Daniel Jun
What are artificial neural networks and what they can do?
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2005;149(2):221-4.
2005: Lucie Bartosova; Kamil Kuca; Daniel Jun; Gabriela Kunesova
Bispyridinium oximes as antidotal treatment of cyclosarin poisoning-in vitro and in vivo testing.
International journal of toxicology 2005;24(6):399-402.
2005: Kamil Kuca; Jiri Cabal; Kamil Musilek; Daniel Jun; Jiri Bajgar
Effective bisquaternary reactivators of tabun-inhibited AChE.
Journal of applied toxicology : JAT 2005;25(6):491-5.
2005: Kamil Musilek; Kamil Kuca; Daniel Jun; Vlastimil Dohnal; Martin Dolezal
Synthesis of a novel series of bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase.
Journal of enzyme inhibition and medicinal chemistry 2005;20(5):409-15.
2005: Jiri Cabal; Kamil Kuca; Daniel Jun; Jiri Bajgar; Martina Hrabinová
[A comparison of the efficacy of the reactivators of acetylcholinesterase inhibited with tabun].
Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti 2005;54(4):192-5.
2005: Vlastimil Dohnal; Kamil Kuca; Daniel Jun
[Methods of artificial intelligence: a new trend in pharmacy].
Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti 2005;54(4):163-7.
2005: Kamil Kuca; Jiri Cabal; Daniel Jun; Jirí Kassa; Lucie Bartosová; Gabriela Kunesová
In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions.
Journal of applied toxicology : JAT 2005;25(4):296-300.
2005: Kamil Kuca; Jiri Cabal; Jirí Kassa; Daniel Jun; Martina Hrabinová
Comparison of in vitro potency of oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain.
Journal of applied toxicology : JAT 2005;25(4):271-6.
2005: Tae-Hyuk Kim; Kamil Kuca; Daniel Jun; Young-Sik Jung
Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents.
Bioorganic & medicinal chemistry letters 2005;15(11):2914-7.
2005: Kamil Kuca; Lucie Bartosová; Daniel Jun; Jirí Patocka; Jiri Cabal; Jirí Kassa; Gabriela Kunesová
New quaternary pyridine aldoximes as casual antidotes against nerve agents intoxications.
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2005;149(1):75-82.
2005: Jiri Patockal; Daniel Jun; Kamil Kucal
In vitro inactivation of rat brain acetylcholinesterase by DSP-4 and its derivatives OS-21 and OS-23 and protective activity of tacrine (9-amino-1,2,3,4-tetrahydroacridine).
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2005;48(3-4):145-8.
2005: Kamil Kuca; Jiri Cabal; Jirí Kassa; Daniel Jun; Martina Hrabinová
A comparison of the potency of the oxime HLö-7 and currently used oximes (HI-6, pralidoxime, obidoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2005;48(2):81-6.
2004: Josef Jampílek; Martin Dolezal; J Kunes; P Víchová; Daniel Jun; Jirí Hanika; R O'Connor; M Clynes
Synthesis of (2E)-2-methyl-3-(4-([4-(quinolin-2-ylmethoxy)phenyl]sulfanyl)phenyl)prop-2-enoic acid (VUFB 20609) and 2-methyl-3-(4-([4-(quinolin-2-ylmethoxy)phenyl]sulfanyl)phenyl)propanoic acid (VUFB 20584) as potential antileukotrienic agents.
The Journal of pharmacy and pharmacology 2004;56(6):783-94.
2004: Jirí Patocka; Kamil Kuca; Daniel Jun
Acetylcholinesterase and butyrylcholinesterase--important enzymes of human body.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2004;47(4):215-28.
2004: Kamil Kuca; Jirí Patocka; Jiri Cabal; Daniel Jun
Reactivation of organophosphate-inhibited acetylcholinesterase by quaternary pyridinium aldoximes.
Neurotoxicity research 2004;6(7-8):565-70.
2003: V Opletalová; Ludek Jahodár; Daniel Jun; Lubomír Opletal
[Chalcones (1,3-diarylpropen-1-ones) and their analogs as potential therapeutic agents in cardiovascular system diseases].
Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti 2003;52(1):12-9.