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Richard Cerione

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Xu Peng; Marc A Antonyak; Joseph E Druso; Jun-Lin Guan; Yixin Jin; Qiong Lin; Yang Liu; Richard A Cerione
Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice.
Kristin F Wilson; Jon W Erickson; Marc A Antonyak; Richard A Cerione
Rho GTPases and their roles in cancer metabolism.
Tina Freisinger; Erwin Frey; Jared Johnson; Ben Klünder; Nikola Müller; Garwin Pichler; Gisela Beck; Charles Boone; Richard A Cerione; Michael Costanzo; Roland Wedlich-Söldner
Establishment of a robust single axis of cell polarity by coupling multiple positive feedback loops.

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2013: Xu Peng; Marc A Antonyak; Joseph E Druso; Jun-Lin Guan; Yixin Jin; Qiong Lin; Yang Liu; Richard A Cerione
Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice.
Protein & cell 2013;4(3):231-42.
2013: Kristin F Wilson; Jon W Erickson; Marc A Antonyak; Richard A Cerione
Rho GTPases and their roles in cancer metabolism.
Trends in molecular medicine 2013;19(2):74-82.
2013: Tina Freisinger; Erwin Frey; Jared Johnson; Ben Klünder; Nikola Müller; Garwin Pichler; Gisela Beck; Charles Boone; Richard A Cerione; Michael Costanzo; Roland Wedlich-Söldner
Establishment of a robust single axis of cell polarity by coupling multiple positive feedback loops.
Nature communications 2013;4():1807.
2012: Marc A Antonyak; Kristin F Wilson; Richard A Cerione
R(h)oads to microvesicles.
Small GTPases 2012;3(4):219-24.
2012: Sungsoo M Yoo; Marc A Antonyak; Richard A Cerione
The adaptor protein and Arf GTPase-activating protein Cat-1/Git-1 is required for cellular transformation.
The Journal of biological chemistry 2012;287(37):31462-70.
2012: Yeyun Zhou; Richard A Cerione; Jintang Du; Bin He; Hening Lin; Hongmin Zhang; Quan Hao
The bicyclic intermediate structure provides insights into the desuccinylation mechanism of human sirtuin 5 (SIRT5).
The Journal of biological chemistry 2012;287(34):28307-14.
2012: Shawn K Milano; Ryan Pereira; Marc A Antonyak; Woojin Kwon; Richard A Cerione
Characterization of a novel activated Ran GTPase mutant and its ability to induce cellular transformation.
The Journal of biological chemistry 2012;287(30):24955-66.
2012: William P Katt; Sekar Ramachandran; Jon W Erickson; Richard A Cerione
Dibenzophenanthridines as inhibitors of glutaminase C and cancer cell proliferation.
Molecular cancer therapeutics 2012;11(6):1269-78.
2012: Manuela Basso; Jill Berlin; Richard A Cerione; Sunghee Cho; Renee Haskew-Layton; Siiri Iismaa; Eunhee Kim; Brendan Ko; Sama F Sleiman; Dianna Willis; Li Xia; Marc A Antonyak; Rajiv R Ratan
Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(19):6561-9.
2012: Garima Singh; Sekar Ramachandran; Richard A Cerione
A constitutively active Gα subunit provides insights into the mechanism of G protein activation.
Biochemistry 2012;51(15):3232-40.
2012: Jared L Johnson; Jon W Erickson; Richard A Cerione
C-terminal di-arginine motif of Cdc42 protein is essential for binding to phosphatidylinositol 4,5-bisphosphate-containing membranes and inducing cellular transformation.
The Journal of biological chemistry 2012;287(8):5764-74.
2012: Jared Johnson; Richard A Cerione; Jon W Erickson
A quantitative fluorometric approach for measuring the interaction of RhoGDI with membranes and Rho GTPases.
Methods in molecular biology (Clifton, N.J.) 2012;827():107-19.
2011: Jintang Du; Quan Hao; Bin He; Hong Jiang; Saba Khan; Jungwoo Kim; Jun Huyn Kim; Johan Auwerx; Richard A Cerione; Wei Chen; Brian Hyun Choi; Xiaoyang Su; Jimin Woo; Jiu Jiu Yu; Sheng Zhang; Yeyun Zhou; Hening Lin
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.
Science (New York, N.Y.) 2011;334(6057):806-9.
2011: Lindsey K Boroughs; Marc A Antonyak; Jared L Johnson; Richard A Cerione
A unique role for heat shock protein 70 and its binding partner tissue transglutaminase in cancer cell migration.
The Journal of biological chemistry 2011;286(43):37094-107.
2011: Sekar Ramachandran; Richard A Cerione
A dominant-negative Galpha mutant that traps a stable rhodopsin-Galpha-GTP-betagamma complex.
The Journal of biological chemistry 2011;286(14):12702-11.
2011: Marc A Antonyak; Bo Li; Lindsey K Boroughs; Jared L Johnson; Joseph E Druso; Kirsten L Bryant; David Holowka; Richard A Cerione
Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(12):4852-7.
2011: Xin Wu; Sekar Ramachandran; Miao-Chong J Lin; Richard A Cerione; Jon W Erickson
A minimal Rac activation domain in the unconventional guanine nucleotide exchange factor Dock180.
Biochemistry 2011;50(6):1070-80.
2011: Ulrich Englich; Irina A Kriksunov; Richard A Cerione; Michael J Cook; Richard Gillilan; Sol M Gruner; Qingqui Huang; Chae Un Kim; William Miller; Soren Nielsen; David Schuller; Scott Smith; Doletha M E Szebenyi
Microcrystallography, high-pressure cryocooling and BioSAXS at MacCHESS.
Journal of synchrotron radiation 2011;18(1):70-3.
2010: Jon W Erickson; Richard A Cerione
Glutaminase: a hot spot for regulation of cancer cell metabolism?
Oncotarget 2010;1(8):734-40.
2010: Jian-Bin Wang; Jon W Erickson; Reina Fuji; Sekar Ramachandran; Ping Gao; Ramani Dinavahi; Kristin F Wilson; Andre L B Ambrosio; Sandra M G Dias; Chi Dang; Richard A Cerione
Targeting mitochondrial glutaminase activity inhibits oncogenic transformation.
Cancer cell 2010;18(3):207-19.
2010: Qiyu Feng; Dan Baird; Sungsoo Yoo; Marc Antonyak; Richard A Cerione
Phosphorylation of the cool-1/beta-Pix protein serves as a regulatory signal for the migration and invasive activity of Src-transformed cells.
The Journal of biological chemistry 2010;285(24):18806-16.
2010: Sandra Mg Dias; Richard A Cerione; Kristin F Wilson
Unloading RNAs in the cytoplasm: an "importin" task.
Nucleus (Austin, Tex.) 2010;1(2):139-43.
2010: Thi K Ly; Jianbin Wang; Ryan Pereira; Katherine S Rojas; Xu Peng; Qiyu Feng; Richard A Cerione; Kristin F Wilson
Activation of the Ran GTPase is subject to growth factor regulation and can give rise to cellular transformation.
The Journal of biological chemistry 2010;285(8):5815-26.
2010: Bo Li; Marc A Antonyak; Joseph E Druso; Le Cheng; Alexander Nikitin; Richard A Cerione
EGF potentiated oncogenesis requires a tissue transglutaminase-dependent signaling pathway leading to Src activation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(4):1408-13.
2009: Sandra M G Dias; Kristin F Wilson; Katherine S Rojas; Andre L B Ambrosio; Richard A Cerione
The molecular basis for the regulation of the cap-binding complex by the importins.
Nature structural & molecular biology 2009;16(9):930-7.
2009: Jared L Johnson; Jon W Erickson; Richard A Cerione
New insights into how the Rho guanine nucleotide dissociation inhibitor regulates the interaction of Cdc42 with membranes.
The Journal of biological chemistry 2009;284(35):23860-71.
2009: Marc A Antonyak; Richard A Cerione
Ras and the FAK paradox.
Molecular cell 2009;35(2):141-2.
2009: Marc A Antonyak; Bo Li; Andrew D Regan; Qiyu Feng; Stephanie S Dusaban; Richard A Cerione
Tissue transglutaminase is an essential participant in the epidermal growth factor-stimulated signaling pathway leading to cancer cell migration and invasion.
The Journal of biological chemistry 2009;284(27):17914-25.
2009: Makoto Endo; Marc A Antonyak; Richard A Cerione
Cdc42-mTOR signaling pathway controls Hes5 and Pax6 expression in retinoic acid-dependent neural differentiation.
The Journal of biological chemistry 2009;284(8):5107-18.
2008: Matthew J Phillips; Guillermo Calero; Britton Chan; Sekar Ramachandran; Richard A Cerione
Effector proteins exert an important influence on the signaling-active state of the small GTPase Cdc42.
The Journal of biological chemistry 2008;283(20):14153-64.
2008: Xu Peng; Xiaoyang Wu; Joseph E Druso; Huijun Wei; Ann Yong-Jin Park; Marc S Kraus; Ana Alcaraz; Ju Chen; Shu Chien; Richard A Cerione; Jun-Lin Guan
Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(18):6638-43.
2008: Jon W Erickson; Richard A Cerione
A new tool for G protein analysis.
ACS chemical biology 2008;3(1):24-6.
2008: Carol J DeRegis; Peter B Rahl; Gregory R Hoffman; Richard A Cerione; Ruth N Collins
Mutational analysis of betaCOP (Sec26p) identifies an appendage domain critical for function.
BMC cell biology 2008;9():3.
2007: Sunando Datta; Marc A Antonyak; Richard A Cerione
GTP-binding-defective forms of tissue transglutaminase trigger cell death.
Biochemistry 2007;46(51):14819-29.
2007: Sandra M G Dias; Richard A Cerione
X-ray crystal structures reveal two activated states for RhoC.
Biochemistry 2007;46(22):6547-58.
2007: Fergal P Casey; Daniel Baird; Qiyu Feng; Ryan N Gutenkunst; Joshua J Waterfall; Christopher R Myers; K S Brown; Richard A Cerione; James P Sethna
Optimal experimental design in an epidermal growth factor receptor signalling and down-regulation model.
IET systems biology 2007;1(3):190-202.
2006: Marc A Antonyak; Jaclyn M Jansen; Allison M Miller; Thi K Ly; Makoto Endo; Richard A Cerione
Two isoforms of tissue transglutaminase mediate opposing cellular fates.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(49):18609-14.
2006: Qiong Lin; Wannian Yang; Daniel Baird; Qiyu Feng; Richard A Cerione
Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42.
The Journal of biological chemistry 2006;281(46):35253-62.
2006: Sunando Datta; Marc A Antonyak; Richard A Cerione
Importance of Ca(2+)-dependent transamidation activity in the protection afforded by tissue transglutaminase against doxorubicin-induced apoptosis.
Biochemistry 2006;45(44):13163-74.
2006: Sekar Ramachandran; Richard A Cerione
How GPCRs hit the switch.
Nature structural & molecular biology 2006;13(9):756-7.
2006: Qiyu Feng; Daniel Baird; Xu Peng; Jianbin Wang; Thi Ly; Jun-Lin Guan; Richard A Cerione
Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth.
Nature cell biology 2006;8(9):945-56.
2006: Nancy Fidyk; Jian-Bin Wang; Richard A Cerione
Influencing cellular transformation by modulating the rates of GTP hydrolysis by Cdc42.
Biochemistry 2006;45(25):7750-62.
2006: Sharmistha Majumdar; Sekar Ramachandran; Richard A Cerione
New insights into the role of conserved, essential residues in the GTP binding/GTP hydrolytic cycle of large G proteins.
The Journal of biological chemistry 2006;281(14):9219-26.
2006: Joseph J Wakshlag; C J McNeill; Marc A Antonyak; Jason E Boehm; Reina N Fuji; Cheryl E Balkman; Marsha M Zgola; Richard A Cerione; Rodney L Page
Expression and activity of transglutaminase II in spontaneous tumours of dogs and cats.
Journal of comparative pathology 2006;134(2-3):202-10.
2006: Joseph J Wakshlag; Marc A Antonyak; Jason E Boehm; Karen Boehm; Richard A Cerione
Effects of tissue transglutaminase on beta -amyloid1-42-induced apoptosis.
The protein journal 2006;25(1):83-94.
2006: Qiong Lin; Wannian Yang; Richard A Cerione
Measurement of epidermal growth factor receptor turnover and effects of Cdc42.
Methods in enzymology 2006;406():614-25.
2006: Daniel Baird; Qiyu Feng; Richard A Cerione
Biochemical characterization of the Cool (Cloned-out-of-Library)/Pix (Pak-interactive exchange factor) proteins.
Methods in enzymology 2006;406():58-69.
2005: Ryan Pereira; Richard A Cerione
A switch 3 point mutation in the alpha subunit of transducin yields a unique dominant-negative inhibitor.
The Journal of biological chemistry 2005;280(42):35696-703.
2005: William J Smith; Brant Hamel; Marielle E Yohe; John Sondek; Richard A Cerione; Jason T Snyder
A Cdc42 mutant specifically activated by intersectin.
Biochemistry 2005;44(40):13282-90.
2005: Jian-Bin Wang; Wen Jin Wu; Richard A Cerione
Cdc42 and Ras cooperate to mediate cellular transformation by intersectin-L.
The Journal of biological chemistry 2005;280(24):22883-91.
2005: Daniel Baird; Qiyu Feng; Richard A Cerione
The Cool-2/alpha-Pix protein mediates a Cdc42-Rac signaling cascade.
Current biology : CB 2005;15(1):1-10.
2004: K S Brown; C C Hill; Guillermo Calero; Christopher R Myers; K H Lee; James P Sethna; Richard A Cerione
The statistical mechanics of complex signaling networks: nerve growth factor signaling.
Physical biology 2004;1(3-4):184-95.
2004: Marc A Antonyak; Allison M Miller; Jaclyn M Jansen; Jason E Boehm; Cheryl E Balkman; Joseph J Wakshlag; Rodney L Page; Richard A Cerione
Augmentation of tissue transglutaminase expression and activation by epidermal growth factor inhibit doxorubicin-induced apoptosis in human breast cancer cells.
The Journal of biological chemistry 2004;279(40):41461-7.
2004: Sharmistha Majumdar; Sekar Ramachandran; Richard A Cerione
Perturbing the linker regions of the alpha-subunit of transducin: a new class of constitutively active GTP-binding proteins.
The Journal of biological chemistry 2004;279(38):40137-45.
2004: Qiyu Feng; Daniel Baird; Richard A Cerione
Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/alpha-Pix.
The EMBO journal 2004;23(17):3492-504.
2004: Wannian Yang; Jaclyn M Jansen; Qiong Lin; Sabrina Canova; Richard A Cerione; Chandra Childress
Interaction of activated Cdc42-associated tyrosine kinase ACK2 with HSP90.
The Biochemical journal 2004;382(Pt 1):199-204.
2004: Sekar Ramachandran; Richard A Cerione
Stabilization of an intermediate activation state for transducin by a fluorescent GTP analogue.
Biochemistry 2004;43(27):8778-86.
2004: Lisa A Fortier; Molly M Deak; Stacy A Semevolos; Richard A Cerione
Insulin-like growth factor-I diminishes the activation status and expression of the small GTPase Cdc42 in articular chondrocytes.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2004;22(2):436-45.
2004: Richard A Cerione
Cdc42: new roads to travel.
Trends in cell biology 2004;14(3):127-32.
2004: Jon W Erickson; Richard A Cerione
Structural elements, mechanism, and evolutionary convergence of Rho protein-guanine nucleotide exchange factor complexes.
Biochemistry 2004;43(4):837-42.
2003: Shine Tu; Wen Jin Wu; Jiabin Wang; Richard A Cerione
Epidermal growth factor-dependent regulation of Cdc42 is mediated by the Src tyrosine kinase.
The Journal of biological chemistry 2003;278(49):49293-300.
2003: Wen Jin Wu; Shine Tu; Richard A Cerione
Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation.
Cell 2003;114(6):715-25.
2003: Qiong Lin; Reina N Fuji; Wannian Yang; Richard A Cerione
RhoGDI is required for Cdc42-mediated cellular transformation.
Current biology : CB 2003;13(17):1469-79.
2003: Gregory R Hoffman; Peter B Rahl; Ruth N Collins; Richard A Cerione
Conserved structural motifs in intracellular trafficking pathways: structure of the gammaCOP appendage domain.
Molecular cell 2003;12(3):615-25.
2003: James A Flanders; Qiyu Feng; Shubha Bagrodia; Maria T Laux; Avinash Singavarapu; Richard A Cerione
The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins.
FEBS letters 2003;550(1-3):119-23.
2003: Marc A Antonyak; Conor J McNeill; Joseph J Wakshlag; Jason E Boehm; Richard A Cerione
Activation of the Ras-ERK pathway inhibits retinoic acid-induced stimulation of tissue transglutaminase expression in NIH3T3 cells.
The Journal of biological chemistry 2003;278(18):15859-66.
2003: William James Smith; Nicolas Nassar; Anthony Bretscher; Richard A Cerione; P Andrew Karplus
Structure of the active N-terminal domain of Ezrin. Conformational and mobility changes identify keystone interactions.
The Journal of biological chemistry 2003;278(7):4949-56.
2002: Nancy J Fidyk; Richard A Cerione
Understanding the catalytic mechanism of GTPase-activating proteins: demonstration of the importance of switch domain stabilization in the stimulation of GTP hydrolysis.
Biochemistry 2002;41(52):15644-53.
2002: Guillermo Calero; Kristin F Wilson; Thi Ly; Jorge L Rios-Steiner; Jon Clardy; Richard A Cerione
Structural basis of m7GpppG binding to the nuclear cap-binding protein complex.
Nature structural biology 2002;9(12):912-7.
2002: Mahasin Osman; James B Konopka; Richard A Cerione
Iqg1p links spatial and secretion landmarks to polarity and cytokinesis.
The Journal of cell biology 2002;159(4):601-11.
2002: Shine S Tu; Wen Jin Wu; Wannian Yang; Peri Nolbant; Klaus M Hahn; Richard A Cerione
Antiapoptotic Cdc42 mutants are potent activators of cellular transformation.
Biochemistry 2002;41(41):12350-8.
2002: William J Smith; Richard A Cerione
Crystallization and preliminary crystallographic analysis of the ezrin FERM domain.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 8):1359-61.
2002: Samira Daniel; Mitsuhiko Noda; Richard A Cerione; Geoffrey W G Sharp
A link between Cdc42 and syntaxin is involved in mastoparan-stimulated insulin release.
Biochemistry 2002;41(30):9663-71.
2002: Jason E Boehm; Ugra Singh; Carolyn Combs; Marc A Antonyak; Richard A Cerione
Tissue transglutaminase protects against apoptosis by modifying the tumor suppressor protein p110 Rb.
The Journal of biological chemistry 2002;277(23):20127-30.
2002: Marc A Antonyak; Jason E Boehm; Richard A Cerione
Phosphoinositide 3-kinase activity is required for retinoic acid-induced expression and activation of the tissue transglutaminase.
The Journal of biological chemistry 2002;277(17):14712-6.
2002: Qiong Lin; Charles G Lo; Richard A Cerione; Wannian Yang
The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation.
The Journal of biological chemistry 2002;277(12):10134-8.
2002: Shenping Liu; Richard A Cerione; Jon Clardy
Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2743-7.
2002: Gregory R Hoffman; Richard A Cerione
Signaling to the Rho GTPases: networking with the DH domain.
FEBS letters 2002;513(1):85-91.
2002: Qiyu Feng; John G Albeck; Richard A Cerione; Wannian Yang
Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases.
The Journal of biological chemistry 2002;277(7):5644-50.
2001: Wannian Yang; Qiong Lin; Jihe Zhao; Jun-Lin Guan; Richard A Cerione
The nonreceptor tyrosine kinase ACK2, a specific target for Cdc42 and a negative regulator of cell growth and focal adhesion complexes.
The Journal of biological chemistry 2001;276(47):43987-93.
2001: Marc A Antonyak; U S Singh; D A Lee; Jason E Boehm; C Combs; Marsha M Zgola; Rodney L Page; Richard A Cerione
Effects of tissue transglutaminase on retinoic acid-induced cellular differentiation and protection against apoptosis.
The Journal of biological chemistry 2001;276(36):33582-7.
2001: Shine Tu; Richard A Cerione
Cdc42 is a substrate for caspases and influences Fas-induced apoptosis.
The Journal of biological chemistry 2001;276(22):19656-63.
2001: Wannian Yang; C G Lo; T Dispenza; Richard A Cerione
The Cdc42 target ACK2 directly interacts with clathrin and influences clathrin assembly.
The Journal of biological chemistry 2001;276(20):17468-73.
2001: J W Erickson; Richard A Cerione
Multiple roles for Cdc42 in cell regulation.
Current opinion in cell biology 2001;13(2):153-7.
2001: Gregory R Hoffman; Richard A Cerione
Rac inserts its way into the immune response.
Nature immunology 2001;2(3):194-6.
2001: E Hong-Geller; David Holowka; R P Siraganian; Barbara Baird; Richard A Cerione
Activated Cdc42/Rac reconstitutes Fcepsilon RI-mediated Ca2+ mobilization and degranulation in mutant RBL mast cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(3):1154-9.
2000: Kristin F Wilson; W J Wu; Richard A Cerione
Cdc42 stimulates RNA splicing via the S6 kinase and a novel S6 kinase target, the nuclear cap-binding complex.
The Journal of biological chemistry 2000;275(48):37307-10.
2000: Gregory R Hoffman; Richard A Cerione
Flipping the switch: the structural basis for signaling through the CRIB motif.
Cell 2000;102(4):403-6.
2000: Stephanie J. Walker; Wen Jin Wu; Richard A Cerione; H Alex Brown
Activation of phospholipase D1 by Cdc42 requires the Rho insert region.
The Journal of biological chemistry 2000;275(21):15665-8.
2000: Kristin F Wilson; Richard A Cerione
Signal transduction and post-transcriptional gene expression.
Biological chemistry 2000;381(5-6):357-65.
2000: E Hong-Geller; Richard A Cerione
Cdc42 and Rac stimulate exocytosis of secretory granules by activating the IP(3)/calcium pathway in RBL-2H3 mast cells.
The Journal of cell biology 2000;148(3):481-94.
2000: Gregory R Hoffman; N Nassar; Richard A Cerione
Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI.
Cell 2000;100(3):345-56.
1999: TK Nomanbhoy; Richard A Cerione
Fluorescence assays of Cdc42 interactions with target/effector proteins.
Biochemistry 1999;38(48):15878-84.
1999: Shubha Bagrodia; Richard A Cerione
Pak to the future.
Trends in cell biology 1999;9(9):350-5.
1999: R Lin; Richard A Cerione; D Manor
Specific contributions of the small GTPases Rho, Rac, and Cdc42 to Dbl transformation.
The Journal of biological chemistry 1999;274(33):23633-41.
1999: Shubha Bagrodia; D Bailey; Z Lenard; M Hart; Jun-Lin Guan; R T Premont; S J Taylor; Richard A Cerione
A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins.
The Journal of biological chemistry 1999;274(32):22393-400.
1999: Wannian Yang; Richard A Cerione
Endocytosis: Is dynamin a 'blue collar' or 'white collar' worker?
Current biology : CB 1999;9(14):R511-4.
1999: L M Chen; Shubha Bagrodia; Richard A Cerione; Jorge E Galán
Requirement of p21-activated kinase (PAK) for Salmonella typhimurium-induced nuclear responses.
The Journal of experimental medicine 1999;189(9):1479-88.
1999: Wannian Yang; Qiong Lin; Jun-Lin Guan; Richard A Cerione
Activation of the Cdc42-associated tyrosine kinase-2 (ACK-2) by cell adhesion via integrin beta1.
The Journal of biological chemistry 1999;274(13):8524-30.
1999: Kristin F Wilson; Puri Fortes; U S Singh; M Ohno; Iain W Mattaj; Richard A Cerione
The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction.
The Journal of biological chemistry 1999;274(7):4166-73.
1999: TK Nomanbhoy; J W Erickson; Richard A Cerione
Kinetics of Cdc42 membrane extraction by Rho-GDI monitored by real-time fluorescence resonance energy transfer.
Biochemistry 1999;38(6):1744-50.
1999: A L Berger; Richard A Cerione; JW Erickson
Delineation of two functionally distinct gammaPDE binding sites on the bovine retinal cGMP phosphodiesterase by a mutant gammaPDE subunit.
Biochemistry 1999;38(4):1293-9.
1999: J A Glaven; Ian P Whitehead; Shubha Bagrodia; R Kay; Richard A Cerione
The Dbl-related protein, Lfc, localizes to microtubules and mediates the activation of Rac signaling pathways in cells.
The Journal of biological chemistry 1999;274(4):2279-85.
1998: N Nassar; Gregory R Hoffman; D Manor; J C Clardy; Richard A Cerione
Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP.
Nature structural biology 1998;5(12):1047-52.
1998: W Guo; Michael J Sutcliffe; Richard A Cerione; Robert E Oswald
Identification of the binding surface on Cdc42Hs for p21-activated kinase.
Biochemistry 1998;37(40):14030-7.
1998: Shubha Bagrodia; S J Taylor; K A Jordon; L Van Aelst; Richard A Cerione
A novel regulator of p21-activated kinases.
The Journal of biological chemistry 1998;273(37):23633-6.
1998: S J McCallum; J W Erickson; Richard A Cerione
Characterization of the association of the actin-binding protein, IQGAP, and activated Cdc42 with Golgi membranes.
The Journal of biological chemistry 1998;273(35):22537-44.
1998: Mahasin Osman; Richard A Cerione
Iqg1p, a yeast homologue of the mammalian IQGAPs, mediates cdc42p effects on the actin cytoskeleton.
The Journal of cell biology 1998;142(2):443-55.
1998: WJ Wu; R Lin; Richard A Cerione; D Manor
Transformation activity of Cdc42 requires a region unique to Rho-related proteins.
The Journal of biological chemistry 1998;273(27):16655-8.
1998: DA Leonard; R Lin; Richard A Cerione; D Manor
Biochemical studies of the mechanism of action of the Cdc42-GTPase-activating protein.
The Journal of biological chemistry 1998;273(26):16210-5.
1998: Gregory R Hoffman; N Nassar; R E Oswald; Richard A Cerione
Fluoride activation of the Rho family GTP-binding protein Cdc42Hs.
The Journal of biological chemistry 1998;273(8):4392-9.
1998: U S Singh; Q Li; Richard A Cerione
Identification of the eukaryotic initiation factor 5A as a retinoic acid-stimulated cellular binding partner for tissue transglutaminase II.
The Journal of biological chemistry 1998;273(4):1946-50.
1998: TK Nomanbhoy; Richard A Cerione
Use of fluorescence spectroscopy to study the regulation of small G proteins.
Methods in molecular biology (Clifton, N.J.) 1998;84():237-47.
1997: Wannian Yang; Richard A Cerione
Cloning and characterization of a novel Cdc42-associated tyrosine kinase, ACK-2, from bovine brain.
The Journal of biological chemistry 1997;272(40):24819-24.
1997: R Lin; Shubha Bagrodia; Richard A Cerione; D Manor
A novel Cdc42Hs mutant induces cellular transformation.
Current biology : CB 1997;7(10):794-7.
1997: JW Erickson; Richard A Cerione; Matthew J Hart
Identification of an actin cytoskeletal complex that includes IQGAP and the Cdc42 GTPase.
The Journal of biological chemistry 1997;272(39):24443-7.
1997: Q Li; Richard A Cerione
Communication between switch II and switch III of the transducin alpha subunit is essential for target activation.
The Journal of biological chemistry 1997;272(35):21673-6.
1997: J L Feltham; V Dötsch; S Raza; D Manor; Richard A Cerione; M J Sutcliffe; G Wagner; R E Oswald
Definition of the switch surface in the solution structure of Cdc42Hs.
Biochemistry 1997;36(29):8755-66.
1997: Yuying Gosser; TK Nomanbhoy; B Aghazadeh; D Manor; C Combs; Richard A Cerione; Michael K Rosen
C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases.
Nature 1997;387(6635):814-9.
1997: D C Gamett; G Pearson; Richard A Cerione; I Friedberg
Secondary dimerization between members of the epidermal growth factor receptor family.
The Journal of biological chemistry 1997;272(18):12052-6.
1997: DA Leonard; R S Satoskar; WJ Wu; Shubha Bagrodia; Richard A Cerione; D Manor
Use of a fluorescence spectroscopic readout to characterize the interactions of Cdc42Hs with its target/effector, mPAK-3.
Biochemistry 1997;36(5):1173-80.
1997: A L Berger; Richard A Cerione; JW Erickson
Real time conformational changes in the retinal phosphodiesterase gamma subunit monitored by resonance energy transfer.
The Journal of biological chemistry 1997;272(5):2714-21.
1996: J A Glaven; Ian P Whitehead; T Nomanbhoy; R Kay; Richard A Cerione
Lfc and Lsc oncoproteins represent two new guanine nucleotide exchange factors for the Rho GTP-binding protein.
The Journal of biological chemistry 1996;271(44):27374-81.
1996: U S Singh; Richard A Cerione
Biochemical effects of retinoic acid on GTP-binding Protein/Transglutaminases in HeLa cells. Stimulation of GTP-binding and transglutaminase activity, membrane association, and phosphatidylinositol lipid turnover.
The Journal of biological chemistry 1996;271(44):27292-8.
1996: J W Erickson; C j Zhang; Richard A Kahn; T Evans; Richard A Cerione
Mammalian Cdc42 is a brefeldin A-sensitive component of the Golgi apparatus.
The Journal of biological chemistry 1996;271(43):26850-4.
1996: Y Zheng; J A Glaven; W J Wu; Richard A Cerione
Phosphatidylinositol 4,5-bisphosphate provides an alternative to guanine nucleotide exchange factors by stimulating the dissociation of GDP from Cdc42Hs.
The Journal of biological chemistry 1996;271(39):23815-9.
1996: Y Zheng; D Zangrilli; Richard A Cerione; A Eva
The pleckstrin homology domain mediates transformation by oncogenic dbl through specific intracellular targeting.
The Journal of biological chemistry 1996;271(32):19017-20.
1996: T K Nomanbhoy; Richard A Cerione
Characterization of the interaction between RhoGDI and Cdc42Hs using fluorescence spectroscopy.
The Journal of biological chemistry 1996;271(17):10004-9.
1996: T K Nomanbhoy; D A Leonard; D Manor; Richard A Cerione
Investigation of the GTP-binding/GTPase cycle of Cdc42Hs using extrinsic reporter group fluorescence.
Biochemistry 1996;35(14):4602-8.
1996: Richard A Cerione; Y Zheng
The Dbl family of oncogenes.
Current opinion in cell biology 1996;8(2):216-22.
1996: R Mittal; J W Erickson; Richard A Cerione
Uncoupling of GTP binding from target stimulation by a single mutation in the transducin alpha subunit.
Science (New York, N.Y.) 1996;271(5254):1413-6.
1995: U S Singh; J W Erickson; Richard A Cerione
Identification and biochemical characterization of an 80 kilodalton GTP-binding/transglutaminase from rabbit liver nuclei.
Biochemistry 1995;34(48):15863-71.
1995: Shubha Bagrodia; B Dérijard; R J Davis; Richard A Cerione
Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation.
The Journal of biological chemistry 1995;270(47):27995-8.
1995: Shubha Bagrodia; S J Taylor; C L Creasy; Jonathan Chernoff; Richard A Cerione
Identification of a mouse p21Cdc42/Rac activated kinase.
The Journal of biological chemistry 1995;270(39):22731-7.
1995: D C Gamett; T Greene; A R Wagreich; H H Kim; John G Koland; Richard A Cerione
Heregulin-stimulated signaling in rat pheochromocytoma cells. Evidence for ErbB3 interactions with Neu/ErbB2 and p85.
The Journal of biological chemistry 1995;270(32):19022-7.
1995: J W Erickson; R Mittal; Richard A Cerione
Use of resonance energy transfer to determine the proximity of the guanine nucleotide binding site of transducin relative to a conformationally-sensitive site on the gamma subunit of the cyclic GMP phosphodiesterase.
Biochemistry 1995;34(27):8693-700.
1995: Y Zheng; Michael F Olson; Alan Hall; Richard A Cerione; Deniz Toksoz
Direct involvement of the small GTP-binding protein Rho in lbc oncogene function.
The Journal of biological chemistry 1995;270(16):9031-4.
1995: J V Platko; D A Leonard; Chaker N Adra; Reuben J. Shaw; Richard A Cerione; B Lim
A single residue can modify target-binding affinity and activity of the functional domain of the Rho-subfamily GDP dissociation inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2974-8.
1995: Y Zheng; A Bender; Richard A Cerione
Interactions among proteins involved in bud-site selection and bud-site assembly in Saccharomyces cerevisiae.
The Journal of biological chemistry 1995;270(2):626-30.
1995: D A Leonard; Richard A Cerione
Solubilization of Cdc42Hs from membranes by Rho-GDP dissociation inhibitor.
Methods in enzymology 1995;256():98-105.
1995: Y Zheng; Matthew J Hart; Richard A Cerione
Guanine nucleotide exchange catalyzed by dbl oncogene product.
Methods in enzymology 1995;256():77-84.
1995: Richard A Cerione; D Leonard; Y Zheng
Purification of baculovirus-expressed Cdc42Hs.
Methods in enzymology 1995;256():11-5.
1994: J Peterson; Y Zheng; L Bender; A Myers; Richard A Cerione; A Bender
Interactions between the bud emergence proteins Bem1p and Bem2p and Rho-type GTPases in yeast.
The Journal of cell biology 1994;127(5):1395-406.
1994: D A Leonard; T Evans; M Hart; Richard A Cerione; D Manor
Investigation of the GTP-binding/GTPase cycle of Cdc42Hs using fluorescence spectroscopy.
Biochemistry 1994;33(40):12323-8.
1994: D C Gamett; Richard A Cerione
Oncogenically activated or ligand-stimulated neu kinase stimulates neurite outgrowth in PC12 cells.
FEBS letters 1994;351(3):335-9.
1994: R Mittal; Richard A Cerione; J W Erickson
Aluminum fluoride activation of bovine transducin induces two distinct conformational changes in the alpha subunit.
Biochemistry 1994;33(33):10178-84.
1994: P M Guy; J V Platko; Lewis C Cantley; Richard A Cerione; Kermit L Carraway
Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(17):8132-6.
1994: Y Zheng; Shubha Bagrodia; Richard A Cerione
Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85.
The Journal of biological chemistry 1994;269(29):18727-30.
1994: Mark X Sliwkowski; Gabriele Schaefer; Robert W Akita; Julie A Lofgren; VD Fitzpatrick; A Nuijens; B M Fendly; Richard A Cerione; R L Vandlen; Kermit L Carraway
Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin.
The Journal of biological chemistry 1994;269(20):14661-5.
1994: Kermit L Carraway; Mark X Sliwkowski; Robert W Akita; J V Platko; P M Guy; A Nuijens; A J Diamonti; R L Vandlen; Lewis C Cantley; Richard A Cerione
The erbB3 gene product is a receptor for heregulin.
The Journal of biological chemistry 1994;269(19):14303-6.
1994: W J Phillips; Richard A Cerione
A C-terminal peptide of bovine rhodopsin binds to the transducin alpha-subunit and facilitates its activation.
The Biochemical journal 1994;299 ( Pt 2)():351-7.
1994: Y Zheng; Richard A Cerione; A Bender
Control of the yeast bud-site assembly GTPase Cdc42. Catalysis of guanine nucleotide exchange by Cdc24 and stimulation of GTPase activity by Bem3.
The Journal of biological chemistry 1994;269(4):2369-72.
1994: Matthew J Hart; A Eva; D Zangrilli; S A Aaronson; T Evans; Richard A Cerione; Y Zheng
Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product.
The Journal of biological chemistry 1994;269(1):62-5.
1994: Richard A Cerione
Fluorescence assays for G-protein interactions.
Methods in enzymology 1994;237():409-23.
1993: Chaker N Adra; J Ko; D Leonard; L J Wirth; Richard A Cerione; B Lim
Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I.
Genes, chromosomes & cancer 1993;8(4):253-61.
1993: Y Zheng; Matthew J Hart; K Shinjo; T Evans; A Bender; Richard A Cerione
Biochemical comparisons of the Saccharomyces cerevisiae Bem2 and Bem3 proteins. Delineation of a limit Cdc42 GTPase-activating protein domain.
The Journal of biological chemistry 1993;268(33):24629-34.
1993: Kermit L Carraway; Richard A Cerione
Inhibition of epidermal growth factor receptor aggregation by an antibody directed against the epidermal growth factor receptor extracellular domain.
The Journal of biological chemistry 1993;268(32):23860-7.
1993: J W Erickson; Richard A Cerione
Regulation of the cGMP phosphodiesterase in bovine rod outer segments. Use of resonance energy transfer to distinguish between associative and dissociative activation mechanisms.
The Journal of biological chemistry 1993;268(5):3328-33.
1992: D Leonard; Matthew J Hart; J V Platko; A Eva; W Henzel; T Evans; Richard A Cerione
The identification and characterization of a GDP-dissociation inhibitor (GDI) for the CDC42Hs protein.
The Journal of biological chemistry 1992;267(32):22860-8.
1992: Matthew J Hart; Y Maru; D Leonard; O N Witte; T Evans; Richard A Cerione
A GDP dissociation inhibitor that serves as a GTPase inhibitor for the Ras-like protein CDC42Hs.
Science (New York, N.Y.) 1992;258(5083):812-5.
1992: W J Phillips; S C Wong; Richard A Cerione
Rhodopsin/transducin interactions. II. Influence of the transducin-beta gamma subunit complex on the coupling of the transducin-alpha subunit to rhodopsin.
The Journal of biological chemistry 1992;267(24):17040-6.
1992: W J Phillips; Richard A Cerione
Rhodopsin/transducin interactions. I. Characterization of the binding of the transducin-beta gamma subunit complex to rhodopsin using fluorescence spectroscopy.
The Journal of biological chemistry 1992;267(24):17032-9.
1992: V Narasimhan; Owen P Hamill; Richard A Cerione
The effects of the normal and oncogenic forms of the neu tyrosine kinase, and the corresponding forms of an immunoglobulin E receptor/neu tyrosine kinase fusion protein, on Xenopus oocyte maturation.
FEBS letters 1992;303(2-3):164-8.
1991: Richard A Cerione
Reconstitution of receptor/GTP-binding protein interactions.
Biochimica et biophysica acta 1991;1071(4):473-501.
1991: Matthew J Hart; A Eva; T Evans; S A Aaronson; Richard A Cerione
Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product.
Nature 1991;354(6351):311-4.
1991: Matthew J Hart; K Shinjo; Alan Hall; T Evans; Richard A Cerione
Identification of the human platelet GTPase activating protein for the CDC42Hs protein.
The Journal of biological chemistry 1991;266(31):20840-8.
1991: J W Erickson; Richard A Cerione
Resonance energy transfer as a direct monitor of GTP-binding protein-effector interactions: activated alpha-transducin binding to the cGMP phosphodiesterase in the bovine phototransduction cascade.
Biochemistry 1991;30(29):7112-8.
1991: W J Phillips; Richard A Cerione
Labeling of the beta gamma subunit complex of transducin with an environmentally sensitive cysteine reagent. Use of fluorescence spectroscopy to monitor transducin subunit interactions.
The Journal of biological chemistry 1991;266(17):11017-24.
1990: K Shinjo; John G Koland; Matthew J Hart; V Narasimhan; D I Johnson; T Evans; Richard A Cerione
Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9853-7.
1990: Kermit L Carraway; J G Koland; Richard A Cerione
Location of the epidermal growth factor binding site on the EGF receptor. A resonance energy transfer study.
Biochemistry 1990;29(37):8741-7.
1990: John G Koland; Richard A Cerione
Activation of the EGF receptor tyrosine kinase by divalent metal ions: comparison of holoreceptor and isolated kinase domain properties.
Biochimica et biophysica acta 1990;1052(3):489-98.
1990: John G Koland; K M O'Brien; Richard A Cerione
Expression of epidermal growth factor receptor sequences as E. coli fusion proteins: applications in the study of tyrosine kinase function.
Biochemical and biophysical research communications 1990;166(1):90-100.
1989: W J Phillips; S Trukawinski; Richard A Cerione
An antibody-induced enhancement of the transducin-stimulated cyclic GMP phosphodiesterase activity.
The Journal of biological chemistry 1989;264(28):16679-88.
1989: S Kroll; W J Phillips; Richard A Cerione
The regulation of the cyclic GMP phosphodiesterase by the GDP-bound form of the alpha subunit of transducin.
The Journal of biological chemistry 1989;264(8):4490-7.
1988: W J Phillips; Richard A Cerione
The intrinsic fluorescence of the alpha subunit of transducin. Measurement of receptor-dependent guanine nucleotide exchange.
The Journal of biological chemistry 1988;263(30):15498-505.
1988: J Krupinski; R Rajaram; M Lakonishok; J L Benovic; Richard A Cerione
Insulin-dependent phosphorylation of GTP-binding proteins in phospholipid vesicles.
The Journal of biological chemistry 1988;263(25):12333-41.
1988: Richard A Cerione; S Kroll; R Rajaram; Cecilia G Unson; P Goldsmith; Allen Spiegel
An antibody directed against the carboxyl-terminal decapeptide of the alpha subunit of the retinal GTP-binding protein, transducin. Effects on transducin function.
The Journal of biological chemistry 1988;263(19):9345-52.
1988: W A Horne; M Abdel-Ghany; E Racker; G A Weiland; Robert E Oswald; Richard A Cerione
Functional reconstitution of skeletal muscle Ca2+ channels: separation of regulatory and channel components.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(11):3718-22.
1988: John G Koland; Richard A Cerione
Growth factor control of epidermal growth factor receptor kinase activity via an intramolecular mechanism.
The Journal of biological chemistry 1988;263(5):2230-7.
1986: W A Horne; G A Weiland; Robert E Oswald; Richard A Cerione
Rapid incorporation of the solubilized dihydropyridine receptor into phospholipid vesicles.
Biochimica et biophysica acta 1986;863(2):205-12.