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Vincenzo Cerundolo

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Peter J Jervis; John-Paul Jukes; Paolo Polzella; Justyna Wojno; Gurdyal S Besra; Vincenzo Cerundolo; Yoel R Garcia Diaz; Hemza Ghadbane; Liam R Cox
Design, synthesis, and functional activity of labeled CD1d glycolipid agonists.
Angus Stock; Giorgio Napolitani; Vincenzo Cerundolo
Intestinal DC in migrational imprinting of immune cells.
Lianne C Davis; Duncan Bloor-Young; Vincenzo Cerundolo; Ji-Li Chen; Grant C Churchill; Stuart J Conway; Anthony J Morgan; John Parrington; Eugene Shenderov; Charlotte M Snead; Megan N Stanton-Humphreys; Antony Galione
NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing.

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2013: Peter J Jervis; John-Paul Jukes; Paolo Polzella; Justyna Wojno; Gurdyal S Besra; Vincenzo Cerundolo; Yoel R Garcia Diaz; Hemza Ghadbane; Liam R Cox
Design, synthesis, and functional activity of labeled CD1d glycolipid agonists.
Bioconjugate chemistry 2013;24(4):586-94.
2013: Angus Stock; Giorgio Napolitani; Vincenzo Cerundolo
Intestinal DC in migrational imprinting of immune cells.
Immunology and cell biology 2013;91(3):240-9.
2012: Lianne C Davis; Duncan Bloor-Young; Vincenzo Cerundolo; Ji-Li Chen; Grant C Churchill; Stuart J Conway; Anthony J Morgan; John Parrington; Eugene Shenderov; Charlotte M Snead; Megan N Stanton-Humphreys; Antony Galione
NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing.
Current biology : CB 2012;22(24):2331-7.
2012: K M Silk; Suzanne M Watt; L Carpenter; Vincenzo Cerundolo; T J Davies; N Ichiryu; A J Leishman; Kathleen F Nolan; J D Silk; Paul J Fairchild
Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells.
Gene therapy 2012;19(10):1035-40.
2012: Stefan Porubsky; Mariolina Salio; Yogesh Singh; Anneliese O Speak; Rashad Zafarulla; Mahnaz Bonrouhi; Vincenzo Cerundolo; Julian Dyson; Richard Jennemann; Agnes Lehuen; Bruno Luckow; Ernst Malle; Johannes Müthing; Frances M Platt; Hermann-Josef Gröne
Globosides but not isoglobosides can impact the development of invariant NKT cells and their interaction with dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(6):3007-17.
2012: Peter J Jervis; John-Paul Jukes; Marie Moulis; Vincenzo Cerundolo; Liam R Cox; Hemza Ghadbane; Gurdyal S Besra
Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues.
Carbohydrate research 2012;356():152-62.
2012: Francis Mussai; Carmela De Santo; Vincenzo Cerundolo
Interaction between invariant NKT cells and myeloid-derived suppressor cells in cancer patients: evidence and therapeutic opportunities.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2012;35(6):449-59.
2012: Anneliese O Speak; Daniëlle te Vruchte; Natacha Veerapen; James E Wraith; Nicole M Yanjanin; Nick Platt; Forbes D Porter; Heiko Runz; Mariolina Salio; Dawn Shepherd; Louise Simmons; David A Smith; Michael Beck; Gurdyal S Besra; Vincenzo Cerundolo; Ralf Hartung; Christian J Hendriksz; Jackie Imrie; Robin H Lachmann; Eugen Mengel; Frances M Platt
Invariant natural killer T cells are not affected by lysosomal storage in patients with Niemann-Pick disease type C.
European journal of immunology 2012;42(7):1886-92.
2012: Justyna Wojno; Gurdyal S Besra; Vincenzo Cerundolo; Hemza Ghadbane; John-Paul Jukes; Dawn Shepherd; Liam R Cox
Amide analogues of CD1d agonists modulate iNKT-cell-mediated cytokine production.
ACS chemical biology 2012;7(5):847-55.
2012: Patricia Barral; Vincenzo Cerundolo; María Dolores Sánchez-Niño; Nico van Rooijen; Facundo D Batista
The location of splenic NKT cells favours their rapid activation by blood-borne antigen.
The EMBO journal 2012;31(10):2378-90.
2012: Philippe Robert; Milos Aleksic; Pierre Bongrand; Vincenzo Cerundolo; Omer Dushek; Philip van der Merwe
Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands.
Biophysical journal 2012;102(2):248-57.
2012: Pramod K Srivastava; Vincenzo Cerundolo; Alexander Knuth; James P Allison
An open invitation to the cancer immunology community.
Cancer immunity 2012;12():1.
2011: Shouxiong Huang; Emilie Layre; Cressida A Madigan; John D Altman; Vincenzo Cerundolo; Tan-Yun Cheng; John Shires; David C Young; D Branch Moody
Discovery of deoxyceramides and diacylglycerols as CD1b scaffold lipids among diverse groove-blocking lipids of the human CD1 system.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(48):19335-40.
2011: Jonathan Silk; Laura Vallius; C A Richard Boyd; Ioannis Karydis; Samira Lakhal; Robert Laynes; Cornelius Marcea; Vincenzo Cerundolo
IDO induces expression of a novel tryptophan transporter in mouse and human tumor cells.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(4):1617-25.
2011: Randip Kaur; Jili Chen; Amina Dawoodji; Vincenzo Cerundolo; Yoel R Garcia-Diaz; Justyna Wojno; Liam R Cox; Gurdyal S Besra; Behfar Moghaddam; Yvonne Perrie
Preparation, characterisation and entrapment of a non-glycosidic threitol ceramide into liposomes for presentation to invariant natural killer T cells.
Journal of pharmaceutical sciences 2011;100(7):2724-33.
2011: Bianca L Bozna; Paolo Polzella; Christian Rankl; Rong Zhu; Mariolina Salio; Dawn Shepherd; memed duman; Vincenzo Cerundolo; Peter Hinterdorfer
Binding strength and dynamics of invariant natural killer cell T cell receptor/CD1d-glycosphingolipid interaction on living cells by single molecule force spectroscopy.
The Journal of biological chemistry 2011;286(18):15973-9.
2011: Angus Stock; Sarah Booth; Vincenzo Cerundolo
Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans.
The Journal of experimental medicine 2011;208(4):761-73.
2011: Bo Pei; Anneliese O Speak; Dawn Shepherd; Terry D Butters; Vincenzo Cerundolo; Frances M Platt; Mitchell Kronenberg
Diverse endogenous antigens for mouse NKT cells: self-antigens that are not glycosphingolipids.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(3):1348-60.
2011: Jane C Stinchcombe; Maurizo Arico; Vincenzo Cerundolo; Daniela Pende; Mariolina Salio; Gillian M Griffiths
Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems.
BMC biology 2011;9():45.
2011: Omer Dushek; Yan-Chun Peng; Richard J Wheeler; Hao Zhang; Milos Aleksic; Vincenzo Cerundolo; Ji-Li Chen; Daniel Coombs; Shaun-Paul Cordoba; Tao Dong; Philip van der Merwe
Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation.
Science signaling 2011;4(176):ra39.
2011: Sarah Hutchinson; Stuart Sims; Geraldine O'Hara; Jonathan Silk; Uzi Gileadi; Vincenzo Cerundolo; Paul Klenerman
A dominant role for the immunoproteasome in CD8+ T cell responses to murine cytomegalovirus.
PloS one 2011;6(2):e14646.
2011: Natacha Veerapen; Faye Reddington; Mariolina Salio; Vincenzo Cerundolo; Gurdyal S Besra
Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation.
Bioorganic & medicinal chemistry 2011;19(1):221-8.
2010: Carmela De Santo; Ramon Arscott; Sarah Booth; Ioannis Karydis; Margaret Jones; Ruth Asher; Mariolina Salio; Mark Middleton; Vincenzo Cerundolo
Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A.
Nature immunology 2010;11(11):1039-46.
2010: Andreas Wadle; Axel Mischo; Sabine Strahl; Hiroyoshi Nishikawa; Gerhard Held; Frank Neumann; Beate Wullner; Eliane Fischer; Sascha Kleber; Julia Karbach; Elke Jager; Hiroshi Shiku; Kunle Odunsi; Protul A Shrikant; Alexander Knuth; Vincenzo Cerundolo; Christoph Renner
NY-ESO-1 protein glycosylated by yeast induces enhanced immune responses.
Yeast (Chichester, England) 2010;27(11):919-31.
2010: Sebastian Zeissig; Stephanie K Dougan; Duarte C Barral; Yvonne Junker; Zhangguo Chen; Arthur Kaser; Madelyn Ho; Hannah Mandel; Adam McIntyre; Susan M Kennedy; Gavin F Painter; Natacha Veerapen; Gurdyal S Besra; Vincenzo Cerundolo; Simon Yue; Sarah Beladi; Samuel M Behar; Xiuxu Chen; Jenny E Gumperz; Karine Breckpot; Anna Raper; Amanda Baer; Mark A Exley; Robert A Hegele; Marina Cuchel; Daniel J Rader; Nicholas O Davidson; Richard S Blumberg
Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function.
The Journal of clinical investigation 2010;120(8):2889-99.
2010: Sacha Gnjatic; Yanran Cao; Uta Reichelt; Emre F Yekebas; Christina Nölker; Andreas H Marx; Andreas Erbersdobler; Hiroyoshi Nishikawa; York Hildebrandt; Katrin Bartels; Christiane Horn; Tanja Stahl; Ivan Gout; Valeriy Filonenko; Khoon-Lin Ling; Vincenzo Cerundolo; Tim Luetkens; Gerd Ritter; Kay Friedrichs; Rudolf Leuwer; Susanna Hegewisch-Becker; Jakob R Izbicki; Carsten Bokemeyer; Lloyd J Old; Djordje Atanackovic
NY-CO-58/KIF2C is overexpressed in a variety of solid tumors and induces frequent T cell responses in patients with colorectal cancer.
International journal of cancer. Journal international du cancer 2010;127(2):381-93.
2010: Konstantina Nika; Cristiana Soldani; Mogjiborahman Salek; Wolfgang Paster; Adrian Gray; Ruth Etzensperger; Lars Fugger; Paolo Polzella; Vincenzo Cerundolo; Omer Dushek; Thomas Höfer; Antonella Viola; Oreste Acuto
Constitutively active Lck kinase in T cells drives antigen receptor signal transduction.
Immunity 2010;32(6):766-77.
2010: Lionel Franz Poulin; Mariolina Salio; Emmanuel Griessinger; Fernando Anjos-Afonso; Ligia Craciun; Ji-Li Chen; Anna M Keller; Olivier Joffre; Santiago Zelenay; Emma Nye; Alain Le Moine; Florence Faure; Vincent Donckier; David Sancho; Vincenzo Cerundolo; Dominique Bonnet; Caetano Reis e Sousa
Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells.
The Journal of experimental medicine 2010;207(6):1261-71.
2010: Vincenzo Cerundolo; Patricia Barral; Facundo D Batista
Synthetic iNKT cell-agonists as vaccine adjuvants--finding the balance.
Current opinion in immunology 2010;22(3):417-24.
2010: Patricia Barral; Paolo Polzella; Andreas Bruckbauer; Nico van Rooijen; Gurdyal S Besra; Vincenzo Cerundolo; Facundo D Batista
CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes.
Nature immunology 2010;11(4):303-12.
2010: Vincenzo Cerundolo; Mitch Kronenberg
The role of invariant NKT cells at the interface of innate and adaptive immunity.
Seminars in immunology 2010;22(2):59-60.
2010: Milos Aleksic; Omer Dushek; Hao Zhang; Eugene Shenderov; Ji-Li Chen; Vincenzo Cerundolo; Daniel Coombs; Philip van der Merwe
Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time.
Immunity 2010;32(2):163-74.
2010: Ji-Li Chen; Anthony J Morgan; Guillaume Stewart-Jones; Dawn Shepherd; Giovanna Bossi; Linda Wooldridge; Sarah L Hutchinson; Andrew K Sewell; Gillian M Griffiths; Philip van der Merwe; E Yvonne Jones; Antony Galione; Vincenzo Cerundolo
Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(4):1829-39.
2010: Ute F Röhrig; Loay Awad; Aurélien Grosdidier; Pierre Larrieu; Vincent Stroobant; Didier Colau; Vincenzo Cerundolo; Andrew J G Simpson; Pierre Vogel; Benoît J Van den Eynde; Vincent Zoete; Olivier Michielin
Rational design of indoleamine 2,3-dioxygenase inhibitors.
Journal of medicinal chemistry 2010;53(3):1172-89.
2010: Mariolina Salio; Jonathan Silk; Vincenzo Cerundolo
Recent advances in processing and presentation of CD1 bound lipid antigens.
Current opinion in immunology 2010;22(1):81-8.
2009: Mariolina Salio; Vincenzo Cerundolo
Linking inflammation to natural killer T cell activation.
PLoS biology 2009;7(10):e1000226.
2009: Jeffrey Ishizuka; Kristie Grebe; Eugene Shenderov; Bjoern Peters; Qiongyu Chen; Yanchun Peng; Lili Wang; Tao Dong; Valerie Pasquetto; Carla Oseroff; John Sidney; Heather Hickman; Vincenzo Cerundolo; Alessandro Sette; Jack R Bennink; Andrew McMichael; Jonathan W Yewdell
Quantitating T cell cross-reactivity for unrelated peptide antigens.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(7):4337-45.
2009: Victoria J Lawson; Diane Maurice; Jonathan Silk; Vincenzo Cerundolo; Kathleen Weston
Aberrant selection and function of invariant NKT cells in the absence of AP-1 transcription factor Fra-2.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(4):2575-84.
2009: Natacha Veerapen; Manfred Brigl; Salil Garg; Vincenzo Cerundolo; Liam R Cox; Michael B Brenner; Gurdyal S Besra
Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide.
Bioorganic & medicinal chemistry letters 2009;19(15):4288-91.
2009: Thierry Mallevaey; James P Scott-Browne; Jennifer L Matsuda; Mary H Young; Daniel G Pellicci; Onisha Patel; Meena Thakur; Lars Kjer-Nielsen; Stewart K Richardson; Vincenzo Cerundolo; Amy R Howell; James McCluskey; Dale I Godfrey; Jamie Rossjohn; Philippa Marrack; Laurent Gapin
T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoire.
Immunity 2009;31(1):60-71.
2009: Michael J Palmowski; Mathew Parker; Kaushik Choudhuri; Christopher Chiu; Margaret F C Callan; Philip van der Merwe; Vincenzo Cerundolo; Keith G Gould
A single-chain H-2Db molecule presenting an influenza virus nucleoprotein epitope shows enhanced ability at stimulating CD8+ T cell responses in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(8):4565-71.
2009: Guillaume Stewart-Jones; Andreas Wadle; Anja Hombach; Eugene Shenderov; Gerhard Held; Eliane Fischer; Sascha Kleber; Natko Nuber; Frank Stenner-Liewen; Stefan Bauer; Andrew McMichael; Alexander Knuth; Hinrich Abken; Andreas A Hombach; Vincenzo Cerundolo; E Yvonne Jones; Christoph Renner
Rational development of high-affinity T-cell receptor-like antibodies.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(14):5784-8.
2009: Gopal R Bommineni; Jonathan Silk; Mariolina Salio; Rengarajan Balamurugan; Dawn Shepherd; Gerd Ritter; Vincenzo Cerundolo; Richard R Schmidt
Nonglycosidic agonists of invariant NKT cells for use as vaccine adjuvants.
ChemMedChem 2009;4(2):171-5.
2009: Angus Stock; Vincenzo Cerundolo
Analysis of frequency and phenotype of antigen-specific T cells.
Methods in molecular biology (Clifton, N.J.) 2009;514():1-14.
2008: Carmela De Santo; Mariolina Salio; S Hajar Masri; Laurel Yong-Hwa Lee; Tao Dong; Anneliese O Speak; Stefan Porubsky; Sarah Booth; Natacha Veerapen; Gurdyal S Besra; Hermann-Josef Gröne; Frances M Platt; Maria Zambon; Vincenzo Cerundolo
Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans.
The Journal of clinical investigation 2008;118(12):4036-48.
2008: Stefan Porubsky; Bruno Luckow; Mahnaz Bonrouhi; A Speak; Vincenzo Cerundolo; Frances M Platt; Hermann-Josef Gröne
[Glycosphingolipids Gb3 and iGb3. In vivo roles in hemolytic-uremic syndrome and iNKT cell function].
Der Pathologe 2008;29 Suppl 2():297-302.
2008: Anneliese O Speak; Vincenzo Cerundolo; Frances M Platt
CD1d presentation of glycolipids.
Immunology and cell biology 2008;86(7):588-97.
2008: Patricia Barral; Julia Eckl-Dorna; Naomi E Harwood; Carmela De Santo; Mariolina Salio; Petr Illarionov; Gurdyal S Besra; Vincenzo Cerundolo; Facundo D Batista
B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(24):8345-50.
2008: Jonathan Silk; Mariolina Salio; Gopal R Bommineni; Dawn Shepherd; Uzi Gileadi; James Brown; S Hajar Masri; Paolo Polzella; Gerd Ritter; Gurdyal S Besra; E Yvonne Jones; Richard R Schmidt; Vincenzo Cerundolo
Cutting edge: nonglycosidic CD1d lipid ligands activate human and murine invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(10):6452-6.
2008: Galit Denkberg; Victoria S Stronge; Efrat Zahavi; Paola Pittoni; Ravit Oren; Dawn Shepherd; Mariolina Salio; Corinna McCarthy; Petr A Illarionov; Philip van der Merwe; Gurdyal S Besra; Paolo Dellabona; Giulia Casorati; Vincenzo Cerundolo; Yoram Reiter
Phage display-derived recombinant antibodies with TCR-like specificity against alpha-galactosylceramide and its analogues in complex with human CD1d molecules.
European journal of immunology 2008;38(3):829-40.
2008: Eleanor Barnes; M Salio; Vincenzo Cerundolo; L Francesco; Drew M Pardoll; Paul Klenerman; Andrea L Cox
Monocyte derived dendritic cells retain their functional capacity in patients following infection with hepatitis C virus.
Journal of viral hepatitis 2008;15(3):219-28.
2008: Mair Thomas; Jessica M Boname; Sarah Field; Sergey Nejentsev; Mariolina Salio; Vincenzo Cerundolo; Mark Wills; Paul J Lehner
Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(5):1656-61.
2008: Jonathan Silk; Mariolina Salio; James Brown; E Yvonne Jones; Vincenzo Cerundolo
Structural and functional aspects of lipid binding by CD1 molecules.
Annual review of cell and developmental biology 2008;24():369-95.
2008: Luciene Lopes; Marie Dewannieux; Uzi Gileadi; Ranbir Bailey; Yasuhiro Ikeda; Christopher Whittaker; Matthew P Collin; Vincenzo Cerundolo; Mizuki Tomihari; Kiyoshi Ariizumi; Mary K Collins
Immunization with a lentivector that targets tumor antigen expression to dendritic cells induces potent CD8+ and CD4+ T-cell responses.
Journal of virology 2008;82(1):86-95.
2007: Mariolina Salio; Anneliese O Speak; Dawn Shepherd; Paolo Polzella; Petr A Illarionov; Natacha Veerapen; Gurdyal S Besra; Frances M Platt; Vincenzo Cerundolo
Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(51):20490-5.
2007: Michael Koch; Simon Camp; Trevor Collen; David Avila; Jan Salomonsen; Hans-Joachim Wallny; Andrew van Hateren; Lawrence Hunt; Jansen P Jacob; Fiona Johnston; Denise Anne Marston; Iain Shaw; P Rod Dunbar; Vincenzo Cerundolo; E Yvonne Jones; Jim Kaufman
Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding.
Immunity 2007;27(6):885-99.
2007: Kate E Matthews; Jim S Qin; Jianping Yang; Ian F Hermans; Michael J Palmowski; Vincenzo Cerundolo; franca ronchese
Increasing the survival of dendritic cells in vivo does not replace the requirement for CD4+ T cell help during primary CD8+ T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):5738-47.
2007: E Yvonne Jones; Mariolina Salio; Vincenzo Cerundolo
T cell receptors get back to basics.
Nature immunology 2007;8(10):1033-5.
2007: Victoria S Stronge; Mariolina Salio; E Yvonne Jones; Vincenzo Cerundolo
A closer look at CD1d molecules: new horizons in studying NKT cells.
Trends in immunology 2007;28(10):455-62.
2007: Gerhard Held; Andreas Wadle; Nina Dauth; Guillaume Stewart-Jones; Christine Sturm; Markus Thiel; Carsten Zwick; Detlef Dieckmann; Gerold Schuler; Hennie Hoogenboom; Frédéric Lévy; Vincenzo Cerundolo; Michael Pfreundschuh; Christoph Renner
MHC-peptide-specific antibodies reveal inefficient presentation of an HLA-A*0201-restricted, Melan-A-derived peptide after active intracellular processing.
European journal of immunology 2007;37(7):2008-17.
2007: Corinna McCarthy; Dawn Shepherd; Sebastian Fleire; Victoria S Stronge; Michael Koch; Petr A Illarionov; Giovanna Bossi; Mariolina Salio; Galit Denkberg; Faye Reddington; Andrea Tarlton; Gopal R Bommineni; Richard R Schmidt; Yoram Reiter; Gillian M Griffiths; Philip van der Merwe; Gurdyal S Besra; E Yvonne Jones; Facundo D Batista; Vincenzo Cerundolo
The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation.
The Journal of experimental medicine 2007;204(5):1131-44.
2007: Linda Wooldridge; Anna Lissina; Jonathan Vernazza; Emma Gostick; Bruno Laugel; Sarah L Hutchinson; Mirza Fareed; P Rod Dunbar; Jonathan M Boulter; Meir Glick; Vincenzo Cerundolo; Hugo A van den Berg; David A Price; Andrew K Sewell
Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region.
European journal of immunology 2007;37(5):1323-33.
2007: Anneliese O Speak; Mariolina Salio; David C A Neville; Josette Fontaine; David A Priestman; Nick Platt; Tanya Heare; Terry D Butters; Raymond A Dwek; François Trottein; Mark A Exley; Vincenzo Cerundolo; Frances M Platt
Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(14):5971-6.
2007: Stefan Porubsky; Anneliese O Speak; Bruno Luckow; Vincenzo Cerundolo; Frances M Platt; Hermann-Josef Gröne
Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(14):5977-82.
2007: Khoon-Lin Ling; Nicolas Dulphy; Pru Bahl; Mariolina Salio; Kevin Maskell; Juan Piris; Bryan F Warren; Bruce D George; N J McC Mortensen; Vincenzo Cerundolo
Modulation of CD103 expression on human colon carcinoma-specific CTL.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):2908-15.
2007: Ian F Hermans; Jonathan Silk; Uzi Gileadi; S Hajar Masri; Dawn Shepherd; Kathryn J Farrand; Mariolina Salio; Vincenzo Cerundolo
Dendritic cell function can be modulated through cooperative actions of TLR ligands and invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):2721-9.
2007: Christopher Chiu; Adrian G Heaps; Vincenzo Cerundolo; Andrew J McMichael; Charles R M Bangham; Margaret F C Callan
Early acquisition of cytolytic function and transcriptional changes in a primary CD8+ T-cell response in vivo.
Blood 2007;109(3):1086-94.
2007: Khoon-Lin Ling; Sarah E Pratap; Gaynor J Bates; Baljit Singh; N J McC Mortensen; Bruce D George; Bryan F Warren; Juan Piris; Giovanna Roncador; Stephen B Fox; Alison H Banham; Vincenzo Cerundolo
Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients.
Cancer immunity 2007;7():7.
2006: Vincenzo Cerundolo; Henri de la Salle
Description of HLA class I- and CD8-deficient patients: Insights into the function of cytotoxic T lymphocytes and NK cells in host defense.
Seminars in immunology 2006;18(6):330-6.
2006: Angelina J Mosley; Kiran Meekings; Corinna McCarthy; Dawn Shepherd; Vincenzo Cerundolo; Ralph Mazitschek; Yuetsu Tanaka; Graham P Taylor; Charles R M Bangham
Histone deacetylase inhibitors increase virus gene expression but decrease CD8+ cell antiviral function in HTLV-1 infection.
Blood 2006;108(12):3801-7.
2006: Stephan D Gadola; Jonathan Silk; Aruna Jeans; Petr A Illarionov; Mariolina Salio; Gurdyal S Besra; Raymond A Dwek; Terry D Butters; Frances M Platt; Vincenzo Cerundolo
Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases.
The Journal of experimental medicine 2006;203(10):2293-303.
2006: Michael J Palmowski; Uzi Gileadi; Mariolina Salio; Awen Gallimore; Maggie Millrain; Edward James; Caroline Addey; Diane Scott; Julian Dyson; Elizabeth Simpson; Vincenzo Cerundolo
Role of immunoproteasomes in cross-presentation.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(2):983-90.
2006: Marco A Purbhoo; Deborah H Sutton; Joanna E Brewer; Rebecca E Mullings; Maxine E Hill; Tara Mahon; Julia Karbach; Elke Jäger; Brian Cameron; Nikolai M Lissin; Paresh Vyas; Ji-Li Chen; Vincenzo Cerundolo; Bent K Jakobsen
Quantifying and imaging NY-ESO-1/LAGE-1-derived epitopes on tumor cells using high affinity T cell receptors.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7308-16.
2006: Yu Sin Lau; Afsie Sabokbar; Henk Giele; Vincenzo Cerundolo; W Hofstetter; Nicholas A Athanasou
Malignant melanoma and bone resorption.
British journal of cancer 2006;94(10):1496-503.
2006: Jiquan Zhang; Anna Raper; Noriko Sugita; Ravi Hingorani; Mariolina Salio; Michael J Palmowski; Vincenzo Cerundolo; Paul R Crocker
Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors.
Blood 2006;107(9):3600-8.
2006: Isabel Quiroga; Mariolina Salio; Dicken D H Koo; Lucia Cerundolo; Dawn Shepherd; Vincenzo Cerundolo; Susan V Fuggle
Expression of MHC class I-related Chain B (MICB) molecules on renal transplant biopsies.
Transplantation 2006;81(8):1196-203.
2006: Ioannis Kotsianidis; Jonathan Silk; Emmanouil Spanoudakis; Scott Patterson; Antonio Almeida; Richard R Schmidt; Costas Tsatalas; George Bourikas; Vincenzo Cerundolo; Irene A G Roberts; Anastasios Karadimitris
Regulation of hematopoiesis in vitro and in vivo by invariant NKT cells.
Blood 2006;107(8):3138-44.
2006: Stephan D Gadola; Michael Koch; Jon Marles-Wright; Nikolai M Lissin; Dawn Shepherd; Gediminas Matulis; Karl Harlos; Peter M Villiger; David I Stuart; Bent K Jakobsen; Vincenzo Cerundolo; E Yvonne Jones
Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors.
The Journal of experimental medicine 2006;203(3):699-710.
2006: Nan Chen; Corinna McCarthy; Hal Drakesmith; Demin Li; Vincenzo Cerundolo; Andrew J McMichael; Gavin Screaton; Xiao-Ning Xu
HIV-1 down-regulates the expression of CD1d via Nef.
European journal of immunology 2006;36(2):278-86.
2006: Kamel Ait-Tahar; Vincenzo Cerundolo; Alison H Banham; Christian S R Hatton; Tom J Blanchard; Rajko Kusec; Marion Becker; Geoffrey L Smith; Karen Pulford
B and CTL responses to the ALK protein in patients with ALK-positive ALCL.
International journal of cancer. Journal international du cancer 2006;118(3):688-95.
2005: Caroline L Smith; Mirza Fareed; Valerie Pasquetto; David C Tscharke; Michael J Palmowski; P Rod Dunbar; Alessandro Sette; Adrian L Harris; Vincenzo Cerundolo
Immunodominance of poxviral-specific CTL in a human trial of recombinant-modified vaccinia Ankara.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(12):8431-7.
2005: Lydie Trautmann; Marie Rimbert; Klara Echasserieau; Xavier Saulquin; Bérangère Neveu; Julie Dechanet; Vincenzo Cerundolo; Marc Bonneville
Selection of T cell clones expressing high-affinity public TCRs within Human cytomegalovirus-specific CD8 T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):6123-32.
2005: Valerie Pasquetto; Huynh-Hoa Bui; Rielle Giannino; Cindy Banh; Mirza Fareed; John Sidney; Carla Oseroff; David C Tscharke; Kari Irvine; Jack R Bennink; Bjoern Peters; Scott Southwood; Vincenzo Cerundolo; Howard Grey; jon yewdell; Alessandro Sette
HLA-A*0201, HLA-A*1101, and HLA-B*0702 transgenic mice recognize numerous poxvirus determinants from a wide variety of viral gene products.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):5504-15.
2005: Scott Patterson; Ioannis Kotsianidis; Antonio Almeida; Marianna Politou; Amin Rahemtulla; Bini Matthew; Richard R Schmidt; Vincenzo Cerundolo; Irene A G Roberts; Anastasios Karadimitris
Human invariant NKT cells are required for effective in vitro alloresponses.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):5087-94.
2005: Anita Milicic; David A Price; Peter Zimbwa; Bruce L Booth; Helen L Brown; Philippa J Easterbrook; Kara Olsen; Nicola Robinson; Uzi Gileadi; Andrew K Sewell; Vincenzo Cerundolo; Rodney E Phillips
CD8+ T cell epitope-flanking mutations disrupt proteasomal processing of HIV-1 Nef.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4618-26.
2005: Michael Koch; Victoria S Stronge; Dawn Shepherd; Stephan D Gadola; Bini Mathew; Gerd Ritter; Alan Fersht; Gurdyal S Besra; Richard R Schmidt; E Yvonne Jones; Vincenzo Cerundolo
The crystal structure of human CD1d with and without alpha-galactosylceramide.
Nature immunology 2005;6(8):819-26.
2005: Christian Maczek; Thomas G Berger; Beatrice Schuler-Thurner; Erwin S Schultz; Anett Hamann; P Rod Dunbar; Vincenzo Cerundolo; Alexander Steinkasserer; Gerold Schuler
Differences in phenotype and function between spontaneously occurring melan-A-, tyrosinase- and influenza matrix peptide-specific CTL in HLA-A*0201 melanoma patients.
International journal of cancer. Journal international du cancer 2005;115(3):450-5.
2005: Giovanna Roncador; Philip J Brown; Lorena Maestre; Sophie Hue; Jorge Luis Martínez-Torrecuadrada; Khoon-Lin Ling; Sarah Pratap; Christy Toms; Bridget C Fox; Vincenzo Cerundolo; Fiona Powrie; Alison H Banham
Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level.
European journal of immunology 2005;35(6):1681-91.
2005: Peter M Manders; Patricia J Hunter; Aino I Telaranta; James M Carr; Jennifer L Marshall; Marlene Carrasco; Yusuke Murakami; Michael J Palmowski; Vincenzo Cerundolo; Susan M Kaech; Rafi Ahmed; Douglas T Fearon
BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(21):7418-25.
2005: Mariolina Salio; Vincenzo Cerundolo
Viral immunity: cross-priming with the help of TLR3.
Current biology : CB 2005;15(9):R336-9.
2005: Ji-Li Chen; Guillaume Stewart-Jones; Giovanna Bossi; Nikolai M Lissin; Linda Wooldridge; Ed Man-Lik Choi; Gerhard Held; P Rod Dunbar; Robert M Esnouf; malkit sami; Jonathan M Boulter; Pierre J Rizkallah; Christoph Renner; Andrew Sewell; Philip van der Merwe; Bent K Jakobsen; Gillian Griffiths; E Yvonne Jones; Vincenzo Cerundolo
Structural and kinetic basis for heightened immunogenicity of T cell vaccines.
The Journal of experimental medicine 2005;201(8):1243-55.
2005: Joelle Renneson; Mariolina Salio; Naima Mazouz; Michel Goldman; Arnaud Marchant; Vincenzo Cerundolo
Mature dendritic cells differentiated in the presence of interferon-beta and interleukin-3 prime functional antigen-specific CD8 T cells.
Clinical and experimental immunology 2005;139(3):468-75.
2005: Caroline L Smith; P Rod Dunbar; Mirza Fareed; Michael J Palmowski; Dawn Shepherd; Sarah Gilbert; Pierre Coulie; Joerg Schneider; Eric Hoffman; Robert Hawkins; Adrian L Harris; Vincenzo Cerundolo
Recombinant modified vaccinia Ankara primes functionally activated CTL specific for a melanoma tumor antigen epitope in melanoma patients with a high risk of disease recurrence.
International journal of cancer. Journal international du cancer 2005;113(2):259-66.
2004: Jonathan Silk; Ian F Hermans; Uzi Gileadi; Tsung Wen Chong; Dawn Shepherd; Mariolina Salio; Bini Mathew; Richard R Schmidt; Sarah Jane Lunt; Kaye J Williams; Ian J Stratford; Adrian L Harris; Vincenzo Cerundolo
Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy.
The Journal of clinical investigation 2004;114(12):1800-11.
2004: Mary K Collins; Vincenzo Cerundolo
Gene therapy meets vaccine development.
Trends in biotechnology 2004;22(12):623-6.
2004: Eleanor Barnes; Mariolina Salio; Vincenzo Cerundolo; Joanne Medlin; Shona Murphy; Geoffrey Dusheiko; Paul Klenerman
Impact of alpha interferon and ribavirin on the function of maturing dendritic cells.
Antimicrobial agents and chemotherapy 2004;48(9):3382-9.
2004: Daniel C Smith; Mariolina Salio; J Michael Lord; Lynne M Roberts; Vincenzo Cerundolo
Lack of dendritic cell maturation by the plant toxin ricin.
European journal of immunology 2004;34(8):2149-57.
2004: Gal Markel; Hagit Achdout; Gil Katz; Khoon-Lin Ling; Mariolina Salio; Raizy Gruda; Roi Gazit; Sa'ar Mizrahi; Jacob Hanna; Tsufit Gonen-Gross; Tal I Arnon; Niva Lieberman; Noam Stren; Boaz Nachmias; Richard S Blumberg; Guy Steuer; Hannah Blau; Vincenzo Cerundolo; Huda Mussaffi; Ofer Mandelboim
Biological function of the soluble CEACAM1 protein and implications in TAP2-deficient patients.
European journal of immunology 2004;34(8):2138-48.
2004: Gal Markel; Huda Mussaffi; Khoon-Lin Ling; Mariolina Salio; Stephan D Gadola; Guy Steuer; Hannah Blau; Hagit Achdout; María de Miguel; Tsufit Gonen-Gross; Jacob Hanna; Tal I Arnon; Udi Qimron; Ilan Volovitz; Lea Eisenbach; Richard S Blumberg; Angel Porgador; Vincenzo Cerundolo; Ofer Mandelboim
The mechanisms controlling NK cell autoreactivity in TAP2-deficient patients.
Blood 2004;103(5):1770-8.
2004: Mariolina Salio; Michael J Palmowski; Ann Atzberger; Ian F Hermans; Vincenzo Cerundolo
CpG-matured murine plasmacytoid dendritic cells are capable of in vivo priming of functional CD8 T cell responses to endogenous but not exogenous antigens.
The Journal of experimental medicine 2004;199(4):567-79.
2004: Thil Batuwangala; Dawn Shepherd; Stephan D Gadola; Kevin J C Gibson; Nathan R Zaccai; Alan Fersht; Gurdyal S Besra; Vincenzo Cerundolo; E Yvonne Jones
The crystal structure of human CD1b with a bound bacterial glycolipid.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2382-8.
2004: Laura Papagno; Celsa A Spina; Arnaud Marchant; Mariolina Salio; Nathalie Rufer; Susan Little; Tao Dong; Gillian Chesney; Anele Waters; Philippa Easterbrook; P Rod Dunbar; Dawn Shepherd; Vincenzo Cerundolo; Vincent Emery; Paul Griffiths; Christopher Conlon; Andrew J McMichael; Douglas D Richman; Sarah L Rowland-Jones; Victor Appay
Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection.
PLoS biology 2004;2(2):E20.
2004: Ian F Hermans; Jonathan Silk; Jianping Yang; Michael J Palmowski; Uzi Gileadi; Corinna McCarthy; Mariolina Salio; franca ronchese; Vincenzo Cerundolo
The VITAL assay: a versatile fluorometric technique for assessing CTL- and NKT-mediated cytotoxicity against multiple targets in vitro and in vivo.
Journal of immunological methods 2004;285(1):25-40.
2004: Michael J Palmowski; Luciene Lopes; Yasuhiro Ikeda; Mariolina Salio; Vincenzo Cerundolo; Mary K Collins
Intravenous injection of a lentiviral vector encoding NY-ESO-1 induces an effective CTL response.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(3):1582-7.
2004: Vincenzo Cerundolo; Ian F Hermans; Mariolina Salio
Dendritic cells: a journey from laboratory to clinic.
Nature immunology 2004;5(1):7-10.
2003: Linda Wooldridge; Sarah L Hutchinson; Ed Man-Lik Choi; Anna Lissina; Emma Jones; Mirza Fareed; P Rod Dunbar; David A Price; Vincenzo Cerundolo; Andrew K Sewell
Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6650-60.
2003: Ian F Hermans; Tsung Wen Chong; Michael J Palmowski; Adrian L Harris; Vincenzo Cerundolo
Synergistic effect of metronomic dosing of cyclophosphamide combined with specific antitumor immunotherapy in a murine melanoma model.
Cancer research 2003;63(23):8408-13.
2003: Mustapha Faroudi; Clemens Utzny; Mariolina Salio; Vincenzo Cerundolo; Martine Guiraud; Sabina Müller; Salvatore Valitutti
Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: manifestation of a dual activation threshold.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14145-50.
2003: Ian F Hermans; Jonathan Silk; Uzi Gileadi; Mariolina Salio; Bini Mathew; Gerd Ritter; Richard Schmidt; Adrian L Harris; Lloyd J Old; Vincenzo Cerundolo
NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(10):5140-7.
2003: Ed Man-Lik Choi; Ji-Li Chen; Linda Wooldridge; Mariolina Salio; Anna Lissina; Nikolai M Lissin; Ian F Hermans; Jonathan Silk; Mirza Fareed; Michael J Palmowski; P Rod Dunbar; Bent K Jakobsen; Andrew K Sewell; Vincenzo Cerundolo
High avidity antigen-specific CTL identified by CD8-independent tetramer staining.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(10):5116-23.
2003: Mariolina Salio; Nicolas Dulphy; Joelle Renneson; Mark Herbert; Andrew McMichael; Arnaud Marchant; Vincenzo Cerundolo
Efficient priming of antigen-specific cytotoxic T lymphocytes by human cord blood dendritic cells.
International immunology 2003;15(10):1265-73.
2003: Jun-Qi Yang; Avneesh K Singh; Michael T Wilson; Minoru Satoh; Aleksandar Stanic; Jang-June Park; Seokmann Hong; Stephan D Gadola; Akiei Mizutani; Srinivasa R Kakumanu; Westley H Reeves; Vincenzo Cerundolo; Sebastian JOYCE; Luc Van Kaer; Ram Raj Singh
Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):2142-53.
2003: Arnaud Marchant; Victor Appay; Marianne A B van der Sande; Nicolas Dulphy; Corinne Liesnard; Michael Kidd; Steve Kaye; Olubukola Ojuola; Geraldine M A Gillespie; Ana L Vargas Cuero; Vincenzo Cerundolo; Margaret F C Callan; Keith P W J McAdam; Sarah L Rowland-Jones; Catherine Donner; Andrew J McMichael; Hilton Whittle
Mature CD8(+) T lymphocyte response to viral infection during fetal life.
The Journal of clinical investigation 2003;111(11):1747-55.
2003: Stephan D Gadola; Anastasios Karadimitris; Nathan R Zaccai; Mariolina Salio; Nicolas Dulphy; Dawn Shepherd; E Yvonne Jones; Vincenzo Cerundolo
Generation of CD1 tetramers as a tool to monitor glycolipid-specific T cells.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2003;358(1433):875-7.
2003: Anna Wańkowicz-Kalińska; René M J G J van den Wijngaard; Bert J Tigges; Wiete Westerhof; Graham S Ogg; Vincenzo Cerundolo; Walter J Storkus; Pranab K Das
Immunopolarization of CD4+ and CD8+ T cells to Type-1-like is associated with melanocyte loss in human vitiligo.
Laboratory investigation; a journal of technical methods and pathology 2003;83(5):683-95.
2003: Emma Jones; David A Price; Michaela Dahm-Vicker; Vincenzo Cerundolo; Paul Klenerman; Awen Gallimore
The influence of macrophage inflammatory protein-1alpha on protective immunity mediated by antiviral cytotoxic T cells.
Immunology 2003;109(1):68-75.
2003: Mariolina Salio; Marina Cella; William Vermi; Fabio Facchetti; Michael J Palmowski; Caroline L Smith; Dawn Shepherd; Marco COLONna; Vincenzo Cerundolo
Plasmacytoid dendritic cells prime IFN-gamma-secreting melanoma-specific CD8 lymphocytes and are found in primary melanoma lesions.
European journal of immunology 2003;33(4):1052-62.
2003: Georg Lautscham; Tracey A Haigh; Sabine Mayrhofer; Graham Taylor; Debbie Croom-Carter; Alison M Leese; Stephan D Gadola; Vincenzo Cerundolo; Alan B Rickinson; Neil Blake
Identification of a TAP-independent, immunoproteasome-dependent CD8+ T-cell epitope in Epstein-Barr virus latent membrane protein 2.
Journal of virology 2003;77(4):2757-61.
2003: Michaela Lucas; Stephan D Gadola; Ute Meier; Neil T Young; Gillian Harcourt; Anastasios Karadimitris; Nikki Coumi; Dave Brown; Geoffrey Dusheiko; Vincenzo Cerundolo; Paul Klenerman
Frequency and phenotype of circulating Valpha24/Vbeta11 double-positive natural killer T cells during hepatitis C virus infection.
Journal of virology 2003;77(3):2251-7.
2002: Michael J Palmowski; Mariolina Salio; Rod P Dunbar; Vincenzo Cerundolo
The use of HLA class I tetramers to design a vaccination strategy for melanoma patients.
Immunological reviews 2002;188():155-63.
2002: Anna Katharina Simon; Awen Gallimore; Emma Jones; Birgit Sawitzki; Vincenzo Cerundolo; Gavin Screaton
Fas ligand breaks tolerance to self-antigens and induces tumor immunity mediated by antibodies.
Cancer cell 2002;2(4):315-22.
2002: Ed Man-Lik Choi; Michael J Palmowski; J Chen; Vincenzo Cerundolo
The use of chimeric A2K(b) tetramers to monitor HLA A2 immune responses in HLA A2 transgenic mice.
Journal of immunological methods 2002;268(1):35-41.
2002: Stephan D Gadola; Nathan R Zaccai; Karl Harlos; Dawn Shepherd; Julio C Castro-Palomino; Gerd Ritter; Richard R Schmidt; E Yvonne Jones; Vincenzo Cerundolo
Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains.
Nature immunology 2002;3(8):721-6.
2002: Daniel C Smith; Awen Gallimore; Emma Jones; Brenda Roberts; J Michael Lord; Emma D Deeks; Vincenzo Cerundolo; Lynne M Roberts
Exogenous peptides delivered by ricin require processing by signal peptidase for transporter associated with antigen processing-independent MHC class I-restricted presentation.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):99-107.
2002: Meir Glick; David A Price; Annelise Vuidepot; Torben B Andersen; Sarah L Hutchinson; Bruno Laugel; Andrew K Sewell; Jonathan M Boulter; P Rod Dunbar; Vincenzo Cerundolo; Annette Oxenius; John I Bell; W Graham Richards; Bent K Jakobsen
Novel CD8+ T cell antagonists based on beta 2-microglobulin.
The Journal of biological chemistry 2002;277(23):20840-6.
2002: Stephan D Gadola; Nicolas Dulphy; Mariolina Salio; Vincenzo Cerundolo
Valpha24-JalphaQ-independent, CD1d-restricted recognition of alpha-galactosylceramide by human CD4(+) and CD8alphabeta(+) T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(11):5514-20.
2002: Michael J Palmowski; Ed Man-Lik Choi; Ian F Hermans; Sarah Gilbert; Ji-Li Chen; Uzi Gileadi; Mariolina Salio; Aline Van Pel; Stephen Man; Eivor Bonin; Peter Liljestrom; P Rod Dunbar; Vincenzo Cerundolo
Competition between CTL narrows the immune response induced by prime-boost vaccination protocols.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4391-8.
2002: Paul Klenerman; Vincenzo Cerundolo; P Rod Dunbar
Tracking T cells with tetramers: new tales from new tools.
Nature reviews. Immunology 2002;2(4):263-72.
2002: Victor Appay; P Rod Dunbar; Margaret F C Callan; Paul Klenerman; Geraldine M A Gillespie; Laura Papagno; Graham S Ogg; Abigail King; Franziska Lechner; Celsa A Spina; Susan Little; Diane V Havlir; Douglas D Richman; Norbert H Gruener; Gerd R Pape; Anele Waters; Philippa Easterbrook; Mariolina Salio; Vincenzo Cerundolo; Andrew J McMichael; Sarah L Rowland-Jones
Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections.
Nature medicine 2002;8(4):379-85.
2002: Emma Jones; Michaela Dahm-Vicker; Anna Katharina Simon; Angharad Green; Fiona Powrie; Vincenzo Cerundolo; Awen Gallimore
Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice.
Cancer immunity 2002;2():1.
2002: Caroline L Smith; Nicolas Dulphy; Mariolina Salio; Vincenzo Cerundolo
Immunotherapy of colorectal cancer.
British medical bulletin 2002;64():181-200.
2002: Andrew K Sewell; Bruce L Booth; Vincenzo Cerundolo; Rodney E Phillips; David A Price
Differential processing of HLA A2-restricted HIV type 1 cytotoxic T lymphocyte epitopes.
Viral immunology 2002;15(1):193-6.
2001: M Evans; Leszek K Borysiewicz; AS Evans; Martin Rowe; Matthew Jones; Uzi Gileadi; Vincenzo Cerundolo; Stephen Man
Antigen processing defects in cervical carcinomas limit the presentation of a CTL epitope from human papillomavirus 16 E6.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(9):5420-8.
2001: J Hemelaar; F Bex; B Booth; Vincenzo Cerundolo; Andrew McMichael; S Daenke
Human T-cell leukemia virus type 1 Tax protein binds to assembled nuclear proteasomes and enhances their proteolytic activity.
Journal of virology 2001;75(22):11106-15.
2001: C Smith; Vincenzo Cerundolo
Immunotherapy of melanoma.
Immunology 2001;104(1):1-7.
2001: Mariolina Salio; Dawn Shepherd; P Rod Dunbar; Michael J Palmowski; K Murphy; L Wu; Vincenzo Cerundolo
Mature dendritic cells prime functionally superior melan-A-specific CD8+ lymphocytes as compared with nonprofessional APC.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1188-97.
2001: Anthony D Kelleher; Bruce L Booth; Andrew K Sewell; A Oxenius; Vincenzo Cerundolo; Andrew J McMichael; Rodney E Phillips; David A Price
Effects of retroviral protease inhibitors on proteasome function and processing of HIV-derived MHC class I-restricted cytotoxic T lymphocyte epitopes.
AIDS research and human retroviruses 2001;17(11):1063-6.
2001: Xiao-Ning Xu; Marco A Purbhoo; N Chen; Juthathip Mongkolsapaya; J H Cox; UC Meier; Sabrina Tafuro; P Rod Dunbar; Andrew K Sewell; Christopher Hourigan; Victor Appay; Vincenzo Cerundolo; S R Burrows; Andrew J McMichael; Gavin Screaton
A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha3 domain mutants of MHC class I/peptide complex.
Immunity 2001;14(5):591-602.
2001: Anastasios Karadimitris; Stephan D Gadola; M Altamirano; D Brown; A Woolfson; Paul Klenerman; J L Chen; Y Koezuka; Irene A G Roberts; David A Price; Geoffrey Dusheiko; César Milstein; Alan Fersht; Lucio Luzzatto; Vincenzo Cerundolo
Human CD1d-glycolipid tetramers generated by in vitro oxidative refolding chromatography.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3294-8.
2000: P Rod Dunbar; Caroline L Smith; D Chao; Mariolina Salio; Dawn Shepherd; Mirza Fareed; Martin Lipp; Antonio Lanzavecchia; F Sallusto; A Evans; R Russell-Jones; Adrian L Harris; Vincenzo Cerundolo
A shift in the phenotype of melan-A-specific CTL identifies melanoma patients with an active tumor-specific immune response.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6644-52.
2000: Beatrice Schuler-Thurner; Detlef Dieckmann; Petra Keikavoussi; Armin Bender; Christian Maczek; H Jonuleit; C Röder; Ina Haendle; W Leisgang; R Dunbar; Vincenzo Cerundolo; Peter von den Driesch; J Knop; Eva-B Bröcker; A Enk; Eckhart Kämpgen; Gerold Schuler
Mage-3 and influenza-matrix peptide-specific cytotoxic T cells are inducible in terminal stage HLA-A2.1+ melanoma patients by mature monocyte-derived dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(6):3492-6.
2000: Stephan D Gadola; HT Moins-Teisserenc; J Trowsdale; WL Gross; Vincenzo Cerundolo
TAP deficiency syndrome.
Clinical and experimental immunology 2000;121(2):173-8.
2000: Victor Appay; P Rod Dunbar; Vincenzo Cerundolo; Andrew McMichael; Lloyd Czaplewski; Sarah Rowland-Jones
RANTES activates antigen-specific cytotoxic T lymphocytes in a mitogen-like manner through cell surface aggregation.
International immunology 2000;12(8):1173-82.
2000: Ji-Li Chen; P Rod Dunbar; Uzi Gileadi; Elke Jäger; Sacha Gnjatic; Y Nagata; Elisabeth Stockert; Dennis Panicali; Y T Chen; A Knuth; Lloyd J Old; Vincenzo Cerundolo
Identification of NY-ESO-1 peptide analogues capable of improved stimulation of tumor-reactive CTL.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(2):948-55.
2000: Danila Valmori; Valérie Dutoit; Danielle Liénard; Ferdy Lejeune; Daniel Speiser; Donata Rimoldi; Vincenzo Cerundolo; Pierre-Yves Dietrich; Jean-Charles Cerottini; Pedro Romero
Tetramer-guided analysis of TCR beta-chain usage reveals a large repertoire of melan-A-specific CD8+ T cells in melanoma patients.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):533-8.
2000: Graham S Ogg; P Rod Dunbar; Vincenzo Cerundolo; Andrew J McMichael; Nick Lemoine; P Savage
Sensitization of tumour cells to lysis by virus-specific CTL using antibody-targeted MHC class I/peptide complexes.
British journal of cancer 2000;82(5):1058-62.
2000: Peter Tomasec; Veronique M Braud; Carole Rickards; MB Powell; Brian P McSharry; S Gadola; Vincenzo Cerundolo; Leszek K Borysiewicz; A J McMichael; Gavin W G Wilkinson
Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40.
Science (New York, N.Y.) 2000;287(5455):1031.
2000: Sarah J Youde; P R Dunbar; E M Evans; Alison Fiander; Leszek K Borysiewicz; Vincenzo Cerundolo; Stephen Man
Use of fluorogenic histocompatibility leukocyte antigen-A*0201/HPV 16 E7 peptide complexes to isolate rare human cytotoxic T-lymphocyte-recognizing endogenous human papillomavirus antigens.
Cancer research 2000;60(2):365-71.
2000: Danila Valmori; Frédéric Lévy; Isabelle Miconnet; Paul Zajac; Giulio C Spagnoli; Donata Rimoldi; Danielle Liénard; Vincenzo Cerundolo; Jean-Charles Cerottini; Pedro Romero
Induction of potent antitumor CTL responses by recombinant vaccinia encoding a melan-A peptide analogue.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):1125-31.
2000: Vincenzo Cerundolo
Use of major histocompatibility complex class I tetramers to monitor tumor-specific cytotoxic T lymphocyte response in melanoma patients.
Cancer chemotherapy and pharmacology 2000;46 Suppl():S83-5.
1999: Danila Valmori; Jean-François Fonteneau; Salvatore Valitutti; Nadine Gervois; R Dunbar; Danielle Liénard; Donata Rimoldi; Vincenzo Cerundolo; Francine Jotereau; Jean-Charles Cerottini; Daniel E Speiser; Pedro Romero
Optimal activation of tumor-reactive T cells by selected antigenic peptide analogues.
International immunology 1999;11(12):1971-80.
1999: Uzi Gileadi; HT Moins-Teisserenc; I Correa; Bruce L Booth; P Rod Dunbar; Andrew K Sewell; J Trowsdale; Rodney E Phillips; Vincenzo Cerundolo
Generation of an immunodominant CTL epitope is affected by proteasome subunit composition and stability of the antigenic protein.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(11):6045-52.
1999: HT Moins-Teisserenc; Stephan D Gadola; M Cella; P Rod Dunbar; A Exley; N Blake; C Baykal; J Lambert; Paul L Bigliardi; M Willemsen; M Jones; S Buechner; Marco COLONna; WL Gross; Vincenzo Cerundolo; C Baycal
Association of a syndrome resembling Wegener's granulomatosis with low surface expression of HLA class-I molecules.
Lancet 1999;354(9190):1598-603.
1999: JA Whelan; P Rod Dunbar; David A Price; Marco A Purbhoo; Franziska Lechner; Graham S Ogg; G Griffiths; Rodney E Phillips; Vincenzo Cerundolo; Andrew K Sewell
Specificity of CTL interactions with peptide-MHC class I tetrameric complexes is temperature dependent.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4342-8.
1999: Daniel E Speiser; Mikaël J Pittet; Danila Valmori; R Dunbar; Donata Rimoldi; Danielle Liénard; H Robson MacDonald; Jean-Charles Cerottini; Vincenzo Cerundolo; Pedro Romero
In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes.
The Journal of experimental medicine 1999;190(6):775-82.
1999: Mikaël J Pittet; Danila Valmori; P R Dunbar; Daniel E Speiser; Danielle Liénard; Ferdy Lejeune; Katharina Fleischhauer; Vincenzo Cerundolo; Jean-Charles Cerottini; Pedro Romero
High frequencies of naive Melan-A/MART-1-specific CD8(+) T cells in a large proportion of human histocompatibility leukocyte antigen (HLA)-A2 individuals.
The Journal of experimental medicine 1999;190(5):705-15.
1999: Danila Valmori; Mikaël J Pittet; C Vonarbourg; Donata Rimoldi; Danielle Liénard; Daniel Speiser; R Dunbar; Vincenzo Cerundolo; Jean-Charles Cerottini; Pedro Romero
Analysis of the cytolytic T lymphocyte response of melanoma patients to the naturally HLA-A*0201-associated tyrosinase peptide 368-376.
Cancer research 1999;59(16):4050-5.
1999: Uzi Gileadi; Awen Gallimore; P Van der Bruggen; Vincenzo Cerundolo
Effect of epitope flanking residues on the presentation of N-terminal cytotoxic T lymphocyte epitopes.
European journal of immunology 1999;29(7):2213-22.
1999: K L Noakes; H T Teisserenc; J Michael Lord; P R Dunbar; Vincenzo Cerundolo; Lynne M Roberts
Exploiting retrograde transport of Shiga-like toxin 1 for the delivery of exogenous antigens into the MHC class I presentation pathway.
FEBS letters 1999;453(1-2):95-9.
1999: Andrew K Sewell; David A Price; H Teisserenc; Bruce L Booth; Uzi Gileadi; F M Flavin; J Trowsdale; Rodney E Phillips; Vincenzo Cerundolo
IFN-gamma exposes a cryptic cytotoxic T lymphocyte epitope in HIV-1 reverse transcriptase.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7075-9.
1999: P Rod Dunbar; Ji-Li Chen; D Chao; NA Rust; H Teisserenc; Graham S Ogg; P Romero; P Weynants; Vincenzo Cerundolo
Cutting edge: rapid cloning of tumor-specific CTL suitable for adoptive immunotherapy of melanoma.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):6959-62.
1999: Daniel E Speiser; Danila Valmori; Donata Rimoldi; Mikaël J Pittet; Danielle Liénard; Vincenzo Cerundolo; H Robson MacDonald; Jean-Charles Cerottini; Pedro Romero
CD28-negative cytolytic effector T cells frequently express NK receptors and are present at variable proportions in circulating lymphocytes from healthy donors and melanoma patients.
European journal of immunology 1999;29(6):1990-9.
1999: Danila Valmori; Mikaël J Pittet; Donata Rimoldi; Danielle Liénard; R Dunbar; Vincenzo Cerundolo; Ferdy Lejeune; Jean-Charles Cerottini; Pedro Romero
An antigen-targeted approach to adoptive transfer therapy of cancer.
Cancer research 1999;59(9):2167-73.
1999: Danila Valmori; Uzi Gileadi; Catherine Servis; P Rod Dunbar; Jean-Charles Cerottini; Pedro Romero; Vincenzo Cerundolo; Frédéric Lévy
Modulation of proteasomal activity required for the generation of a cytotoxic T lymphocyte-defined peptide derived from the tumor antigen MAGE-3.
The Journal of experimental medicine 1999;189(6):895-906.
1998: Pedro Romero; P R Dunbar; Danila Valmori; Mikaël J Pittet; G S Ogg; Donata Rimoldi; J L Chen; Danielle Liénard; Jean-Charles Cerottini; Vincenzo Cerundolo
Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytolytic T lymphocytes.
The Journal of experimental medicine 1998;188(9):1641-50.
1998: Neil T Young; NA Rust; Margaret J Dallman; Vincenzo Cerundolo; Peter J Morris; Ken I Welsh
Independent contributions of HLA epitopes and killer inhibitory receptor expression to the functional alloreactive specificity of natural killer cells.
Human immunology 1998;59(11):700-12.
1998: Neil T Young; Arend Mulder; Vincenzo Cerundolo; Frans H J Claas; Ken I Welsh
Expression of HLA class I antigens in transporter associated with antigen processing (TAP)-deficient mutant cell lines.
Tissue antigens 1998;52(4):368-73.
1998: Graham S Ogg; P Rod Dunbar; P Romero; J L Chen; Vincenzo Cerundolo
High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo.
The Journal of experimental medicine 1998;188(6):1203-8.
1998: Graham S Ogg; X Jin; Sebastian Bonhoeffer; P R Dunbar; M A Nowak; SP Monard; J P Segal; Yunzhen Cao; Sarah L Rowland-Jones; Vincenzo Cerundolo; Arlene Hurley; MH Markowitz; David D Ho; Douglas F Nixon; Andrew J McMichael
Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA.
Science (New York, N.Y.) 1998;279(5359):2103-6.
1998: P Rod Dunbar; Graham S Ogg; J Chen; NA Rust; P van der Bruggen; Vincenzo Cerundolo
Direct isolation, phenotyping and cloning of low-frequency antigen-specific cytotoxic T lymphocytes from peripheral blood.
Current biology : CB 1998;8(7):413-6.
1998: V M Braud; Andrew J McMichael; Vincenzo Cerundolo
Differential processing of influenza nucleoprotein in human and mouse cells.
European journal of immunology 1998;28(2):625-35.
1997: H Teisserenc; W Schmitt; Neil Blake; R Dunbar; Stephan D Gadola; WL Gross; A Exley; Vincenzo Cerundolo
A case of primary immunodeficiency due to a defect of the major histocompatibility gene complex class I processing and presentation pathway.
Immunology letters 1997;57(1-3):183-7.
1997: Vincenzo Cerundolo; AM Benham; Veronique M Braud; S Mukherjee; K Gould; B Macino; Jacques Neefjes; A Townsend
The proteasome-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells.
European journal of immunology 1997;27(1):336-41.
1995: Tim Elliott; A Willis; Vincenzo Cerundolo; A Townsend
Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum.
The Journal of experimental medicine 1995;181(4):1481-91.
1995: Vincenzo Cerundolo; A Kelly; T Elliott; J Trowsdale; A Townsend
Genes encoded in the major histocompatibility complex affecting the generation of peptides for TAP transport.
European journal of immunology 1995;25(2):554-62.
1993: J Elvin; C Potter; Tim Elliott; Vincenzo Cerundolo; A Townsend
A method to quantify binding of unlabeled peptides to class I MHC molecules and detect their allele specificity.
Journal of immunological methods 1993;158(2):161-71.
1992: Tim Elliott; Vincenzo Cerundolo; A Townsend
Short peptides assist the folding of free class I heavy chains in solution.
European journal of immunology 1992;22(12):3121-5.
1992: Vincenzo Cerundolo; Tim Elliott; J Elvin; J Bastin; A Townsend
Association of the human invariant chain with H-2 Db class I molecules.
European journal of immunology 1992;22(9):2243-8.
1992: Tim Elliott; J Elvin; Vincenzo Cerundolo; H Allen; A Townsend
Structural requirements for the peptide-induced conformational change of free major histocompatibility complex class I heavy chains.
European journal of immunology 1992;22(8):2085-91.
1992: Thomas Spies; Vincenzo Cerundolo; Marco COLONna; Peter Cresswell; A Townsend; R DeMars
Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer.
Nature 1992;355(6361):644-6.
1991: J Elvin; Vincenzo Cerundolo; Tim Elliott; A Townsend
A quantitative assay of peptide-dependent class I assembly.
European journal of immunology 1991;21(9):2025-31.
1991: Vincenzo Cerundolo; Tim Elliott; J Elvin; J Bastin; Hans-Georg Rammensee; A Townsend
The binding affinity and dissociation rates of peptides for class I major histocompatibility complex molecules.
European journal of immunology 1991;21(9):2069-75.
1991: Tim Elliott; Vincenzo Cerundolo; J Elvin; A Townsend
Peptide-induced conformational change of the class I heavy chain.
Nature 1991;351(6325):402-6.
1991: Vincenzo Cerundolo; A G Tse; R D Salter; P Parham; A Townsend
CD8 independence and specificity of cytotoxic T lymphocytes restricted by HLA-Aw68.1.
Proceedings. Biological sciences / The Royal Society 1991;244(1310):169-77.
1991: T J Elliott; Vincenzo Cerundolo; C Ohlen; H G Ljunggren; K Karre; A Townsend
Antigen presentation and the association of class-I molecules.
Acta biologica Hungarica 1991;42(1-3):213-29.
1990: T Elliott; A Townsend; Vincenzo Cerundolo
Antigen presentation. Naturally processed peptides.
Nature 1990;348(6298):195-7.
1990: A Townsend; Tim Elliott; Vincenzo Cerundolo; L Foster; B Barber; A Tse
Assembly of MHC class I molecules analyzed in vitro.
Cell 1990;62(2):285-95.
1990: Vincenzo Cerundolo; J Alexander; K Anderson; C Lamb; P Cresswell; Andrew McMichael; Frances Gotch; A Townsend
Presentation of viral antigen controlled by a gene in the major histocompatibility complex.
Nature 1990;345(6274):449-52.