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Peter Moerkerk

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Sarah Derks; Linda J W Bosch; Hanneke E C Niessen; Peter Moerkerk; Sandra M van den Bosch; Beatriz Carvalho; Sandra Mongera; J Willem Voncken; Gerrit A Meijer; Adriaan P de Bruïne; James G Herman; Manon van Engeland
Promoter CpG island hypermethylation- and H3K9me3 and H3K27me3-mediated epigenetic silencing targets the deleted in colon cancer (DCC) gene in colorectal carcinogenesis without affecting neighboring genes on chromosomal region 18q21.
Sarah Derks; Cindy Postma; Beatriz Carvalho; Sandra M van den Bosch; Peter Moerkerk; James G Herman; Matty P Weijenberg; Adriaan P de Bruïne; Gerrit A Meijer; Manon van Engeland
Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations.
Sarah Derks; Cindy Postma; Peter Moerkerk; Sandra M van den Bosch; Beatriz Carvalho; Mario A J A Hermsen; Walter Giaretti; James G Herman; Matty P Weijenberg; Adriaan P de Bruïne; Gerrit A Meijer; Manon van Engeland
Promoter methylation precedes chromosomal alterations in colorectal cancer development.

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All Publications

2009: Sarah Derks; Linda J W Bosch; Hanneke E C Niessen; Peter Moerkerk; Sandra M van den Bosch; Beatriz Carvalho; Sandra Mongera; J Willem Voncken; Gerrit A Meijer; Adriaan P de Bruïne; James G Herman; Manon van Engeland
Promoter CpG island hypermethylation- and H3K9me3 and H3K27me3-mediated epigenetic silencing targets the deleted in colon cancer (DCC) gene in colorectal carcinogenesis without affecting neighboring genes on chromosomal region 18q21.
Carcinogenesis 2009;30(6):1041-8.
2008: Sarah Derks; Cindy Postma; Beatriz Carvalho; Sandra M van den Bosch; Peter Moerkerk; James G Herman; Matty P Weijenberg; Adriaan P de Bruïne; Gerrit A Meijer; Manon van Engeland
Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations.
Carcinogenesis 2008;29(2):434-9.
2006: Sarah Derks; Cindy Postma; Peter Moerkerk; Sandra M van den Bosch; Beatriz Carvalho; Mario A J A Hermsen; Walter Giaretti; James G Herman; Matty P Weijenberg; Adriaan P de Bruïne; Gerrit A Meijer; Manon van Engeland
Promoter methylation precedes chromosomal alterations in colorectal cancer development.
Cellular oncology : the official journal of the International Society for Cellular Oncology 2006;28(5-6):247-57.
2002: Judy van Beijnum; Peter Moerkerk; Andrea J Gerbers; Adriaan P de Bruïne; Jan-Willem Arends; Hennie Hoogenboom; Simon E Hufton
Target validation for genomics using peptide-specific phage antibodies: a study of five gene products overexpressed in colorectal cancer.
International journal of cancer. Journal international du cancer 2002;101(2):118-27.
2002: Veerle A Somers; Ricardo J M G E Brandwijk; Ben Joosten; Peter Moerkerk; Jan-Willem Arends; Paul P C A Menheere; Wendy O Pieterse; Anke Claessen; Rik J Scheper; Hennie Hoogenboom; Simon E Hufton
A panel of candidate tumor antigens in colorectal cancer revealed by the serological selection of a phage displayed cDNA expression library.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(5):2772-80.
1999: Simon E Hufton; Peter Moerkerk; E V Meulemans; Adriaan P de Bruïne; Jan-Willem Arends; Hennie Hoogenboom
Phage display of cDNA repertoires: the pVI display system and its applications for the selection of immunogenic ligands.
Journal of immunological methods 1999;231(1-2):39-51.
1999: Simon E Hufton; Peter Moerkerk; Ricardo J M G E Brandwijk; Adriaan P de Bruïne; Jan-Willem Arends; Hennie Hoogenboom
A profile of differentially expressed genes in primary colorectal cancer using suppression subtractive hybridization.
FEBS letters 1999;463(1-2):77-82.
1998: Simon E Hufton; Peter Moerkerk; AP de Bruine; Jan-Willem Arends; Hennie Hoogenboom
Serological antigen selection of phage displayed colorectal tumour cDNA libraries.
Biochemical Society transactions 1998;26(1):S5.
1996: M Span; Peter Moerkerk; Anton F P M de Goeij; Jan-Willem Arends
A detailed analysis of K-ras point mutations in relation to tumor progression and survival in colorectal cancer patients.
International journal of cancer. Journal international du cancer 1996;69(3):241-5.
1996: J E de Vries; M van Driel; P Marx; Edith Van Der Linden; L de Bruin; Peter Moerkerk; Hein Verspaget; Fred T Bosman; J Ten Kate
Tumorigenic behaviour of c-Ha-ras oncogene transfected CaCo 2 cells is associated with increased proteolytic potency.
Anticancer research 1996;16(1):321-6.
1994: V A Somers; Peter Moerkerk; J J Murtagh; Frederik B J M Thunnissen
A rapid, reliable method for detection of known point mutations: point-EXACCT.
Nucleic acids research 1994;22(22):4840-1.
1994: Peter Moerkerk; Jan-Willem Arends; M van Driel; Adriaan P de Bruïne; Anton F P M de Goeij; J ten Kate
Type and number of Ki-ras point mutations relate to stage of human colorectal cancer.
Cancer research 1994;54(13):3376-8.
1994: A M Jonker; F W Dijkhuis; M J Hardonk; Peter Moerkerk; J Ten Kate; J Grond
Immunohistochemical study of hepatic fibrosis induced in rats by multiple galactosamine injections.
Hepatology (Baltimore, Md.) 1994;19(3):775-81.
1993: S H Korn; Peter Moerkerk; Anton F P M de Goeij
K-ras point mutations in routinely processed tissues: non-radioactive screening by single strand conformational polymorphism analysis.
Journal of clinical pathology 1993;46(7):621-3.
1993: Adriaan P de Bruïne; J E de Vries; Winand N M Dinjens; Peter Moerkerk; Edith Van Der Linden; M M Pijls; J ten Kate; Fred T Bosman
Human Caco-2 cells transfected with c-Ha-Ras as a model for endocrine differentiation in the large intestine.
Differentiation; research in biological diversity 1993;53(1):51-60.
1993: Adriaan P de Bruïne; Winand N M Dinjens; Edith Van Der Linden; M M Pijls; Peter Moerkerk; Fred T Bosman
Extracellular matrix components induce endocrine differentiation in vitro in NCI-H716 cells.
The American journal of pathology 1993;142(3):773-82.
1992: J E De Vries; F H Kornips; J Wiegant; Peter Moerkerk; N Senden; B Schutte; Joep P M Geraedts; Fred T Bosman; J Ten Kate
Chromosomal localization of transfected genes by a combination of hot banding and fluorescence in situ hybridization.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1992;40(7):1053-8.
1992: Adriaan P de Bruïne; Winand N M Dinjens; M M Pijls; E P vd Linden; M J Rousch; Peter Moerkerk; Anton F P M de Goeij; Fred T Bosman
NCI-H716 cells as a model for endocrine differentiation in colorectal cancer.
Virchows Archiv. B, Cell pathology including molecular pathology 1992;62(5):311-20.
1990: Peter Moerkerk; H J Kessels; J ten Kate; Anton F P M de Goeij; Fred T Bosman
Southern and dot blot analysis of DNA from formalin-fixed, paraffin-embedded tissue samples from colonic carcinomas.
Virchows Archiv. B, Cell pathology including molecular pathology 1990;58(5):351-5.
1989: C P Verstijnen; Jan-Willem Arends; Peter Moerkerk; M Pijls; B Kuypers-Engelen; Fred T Bosman
Colonic epithelium reactive monoclonal antibodies. Identification and immunohistochemical localization of the target epitopes.
Histochemistry 1989;92(5):397.
1988: C P Verstijnen; Jan-Willem Arends; Peter Moerkerk; B Schutte; Edith Van Der Linden; B Kuypers-Engelen; Fred T Bosman
Culturing and xenografting of primary colorectal carcinoma cells: comparison of in vitro, and in vivo model and primary tumor.
Anticancer research 1988;8(6):1193-200.
1987: C P Verstijnen; Jan-Willem Arends; Peter Moerkerk; Joep P M Geraedts; K Sekikawa; M P Uitendaal; Fred T Bosman
The establishment and characterization of two new cell lines derived from a single human colonic adenocarcinoma.
Virchows Archiv. B, Cell pathology including molecular pathology 1987;53(4):191-7.
1986: T Wiggers; Jan-Willem Arends; C Verstijnen; Peter Moerkerk; Fred T Bosman
Prognostic significance of CEA immunoreactivity patterns in large bowel carcinoma tissue.
British journal of cancer 1986;54(3):409-14.
1986: C P Verstijnen; Jan-Willem Arends; Peter Moerkerk; S Warnaar; J Hilgers; Fred T Bosman
CEA-specificity of CEA-reactive monoclonal antibodies. Immunochemical and immunocytochemical studies.
Anticancer research 1986;6(1):97-104.
1980: N Kuzumaki; J Hilgers; Peter Moerkerk; R Ber; B Asjö; F Wiener; G Klein
Restriction of C-type viral antigen in H-2/Fv-1 syngeneic mouse somatic cell hybrids.
Intervirology 1980;13(4):201-8.