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Ludek Cervenka

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Sarka Varcabova; Bruce D Hammock; Zuzana Huskova; Sung Hee Hwang; John D Imig; Kento Kitada; Herbert J Kramer; Ludek Cervenka
Antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats is mediated by suppression of the intrarenal renin-angiotensin system.
Zuzana Honetschlägerová; Zuzana Husková; Sung Hee Hwang; John D Imig; Kento Kitada; Libor Kopkan; Herbert kramer; Petr Kujal; Akira Nishiyama; Alexandra Sporková; Šárka Varcabová; Zdena Vernerová; Marcela Bürgelová; Bruce D Hammock; Ludek Cervenka
Antihypertensive and renoprotective actions of soluble epoxide hydrolase inhibition in ANG II-dependent malignant hypertension are abolished by pretreatment with L-NAME.
Jan Neckář; Ivan Netuka; Bohuslav Ošťádal; František Papoušek; Bruce D Hammock; Zuzana Husková; Sung Hee Hwang; John D Imig; František Kolář; Libor Kopkan; Herbert J Kramer; Jiří Malý; Ludek Cervenka
Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension.

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2013: Sarka Varcabova; Bruce D Hammock; Zuzana Huskova; Sung Hee Hwang; John D Imig; Kento Kitada; Herbert J Kramer; Ludek Cervenka
Antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats is mediated by suppression of the intrarenal renin-angiotensin system.
Clinical and experimental pharmacology & physiology 2013;40(4):273-81.
2013: Zuzana Honetschlägerová; Zuzana Husková; Sung Hee Hwang; John D Imig; Kento Kitada; Libor Kopkan; Herbert kramer; Petr Kujal; Akira Nishiyama; Alexandra Sporková; Šárka Varcabová; Zdena Vernerová; Marcela Bürgelová; Bruce D Hammock; Ludek Cervenka
Antihypertensive and renoprotective actions of soluble epoxide hydrolase inhibition in ANG II-dependent malignant hypertension are abolished by pretreatment with L-NAME.
Journal of hypertension 2013;31(2):321-32.
2012: Jan Neckář; Ivan Netuka; Bohuslav Ošťádal; František Papoušek; Bruce D Hammock; Zuzana Husková; Sung Hee Hwang; John D Imig; František Kolář; Libor Kopkan; Herbert J Kramer; Jiří Malý; Ludek Cervenka
Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension.
Clinical science (London, England : 1979) 2012;122(11):513-25.
2012: Libor Kopkan; Herbert kramer; Petr Kujal; Alexandra Sporková; Hsing-Ju Tsai; Zdena Vernerová; Alžběta Vojtíšková; Marcela Bürgelová; Bruce D Hammock; Zuzana Honetschlägerová; Zuzana Husková; Sung Hee Hwang; John D Imig; Šárka Varcabová; Ludek Cervenka
Soluble epoxide hydrolase inhibition exhibits antihypertensive actions independently of nitric oxide in mice with renovascular hypertension.
Kidney & blood pressure research 2012;35(6):595-607.
2012: Ivana Vaněčková; Zdeňka Vaňourková; Zdena Vernerová; Vera Certíková-Chábová; Zuzana Husková; Herbert kramer; Petr Kujal; Petra Skaroupková; Vladimír Tesař; Ludek Cervenka
Effects of combined endothelin A receptor and renin-angiotensin system blockade on the course of end-organ damage in 5/6 nephrectomized Ren-2 hypertensive rats.
Kidney & blood pressure research 2012;35(5):382-92.
2012: Vojtech Melenovsky; Petra Skaroupkova; Vera Torresova; Jan Benes; Libor Kopkan; Ludek Cervenka
The course of heart failure development and mortality in rats with volume overload due to aorto-caval fistula.
Kidney & blood pressure research 2012;35(3):167-73.
2011: Zuzana Honetschlägerová; Zuzana Husková; Sung H Hwang; John D Imig; Libor Kopkan; Herbert J Kramer; Petr Kujal; Alexandra Sporková; Vladimír Tesař; Zdena Vernerová; Vera Certíková Chábová; Bruce D Hammock; Ludek Cervenka
Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats.
Journal of hypertension 2011;29(8):1590-601.
2011: Vojtech Melenovsky; Olena Oliyarnyk; Frantisek Papousek; Jiri Petrak; David Sedmera; Petra Skaroupkova; Hynek Strnad; Cestmir Vlcek; Jan Benes; Jiri Benes; Ludmila Kazdova; Michal Kolar; Ludek Cervenka
Metabolic characterization of volume overload heart failure due to aorto-caval fistula in rats.
Molecular and cellular biochemistry 2011;354(1-2):83-96.
2011: Jan Benes; Ludmila Kazdova; Zdenek Drahota; Josef Houstek; Dasa Medrikova; Jan Kopecky; Nikola Kovarova; Marek Vrbacky; David Sedmera; Hynek Strnad; Michal Kolar; Jiri Petrak; Oldrich Benada; Petra Skaroupkova; Ludek Cervenka; Vojtech Melenovsky
Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats.
Clinical science (London, England : 1979) 2011;121(1):29-41.
2011: Alexandra Sporková; Sárka Varcabová; Bruce D Hammock; Zuzana Husková; Sung Hee Hwang; John D Imig; Libor Kopkan; Herbert J Kramer; Ludek Cervenka
Role of cytochrome P-450 metabolites in the regulation of renal function and blood pressure in 2-kidney 1-clip hypertensive rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2011;300(6):R1468-75.
2011: Jiri Petrak; Jana Pospisilova; Miroslava Sedinova; David Sedmera; Hynek Strnad; Ondrej Vit; Jan Benes; Ludek Cervenka; Petr Jedelsky; Michal Kolar; Lucie Lorkova; Vojtech Melenovsky
Proteomic and transcriptomic analysis of heart failure due to volume overload in a rat aorto-caval fistula model provides support for new potential therapeutic targets - monoamine oxidase A and transglutaminase 2.
Proteome science 2011;9(1):69.
2011: Ivana Vaněčková; Zuzana Husková; Zdeňka Vaňourková; Ludek Cervenka
Castration has antihypertensive and organoprotective effects in male but not in female heterozygous Ren-2 rats.
Kidney & blood pressure research 2011;34(1):46-52.
2011: Jiri Benes; Vojtech Melenovsky; Petra Skaroupkova; Jana Pospisilova; Jiri Petrak; Ludek Cervenka; David Sedmera
Myocardial morphological characteristics and proarrhythmic substrate in the rat model of heart failure due to chronic volume overload.
Anatomical record (Hoboken, N.J. : 2007) 2011;294(1):102-11.
2010: Petr Kujal; Věra Čertíková Chábová; Zdena Vernerová; Agnieszka Walkowska; Elzbieta Kompanowska-Jezierska; Janusz Sadowski; Zdeňka Vaňourková; Zuzana Husková; Martin Opočenský; Petra Skaroupková; Stanislava Schejbalová; Herbert J Kramer; Dan Rakušan; Jan Malý; Ivan Netuka; Ivana Vaněčková; Libor Kopkan; Ludek Cervenka
Similar renoprotection after renin-angiotensin-dependent and -independent antihypertensive therapy in 5/6-nephrectomized Ren-2 transgenic rats: are there blood pressure-independent effects?
Clinical and experimental pharmacology & physiology 2010;37(12):1159-69.
2010: Dan Rakusan; Petr Kujal; Herbert kramer; Zuzana Husková; Zdenka Vanourková; Zdena Vernerová; Iveta Mrázová; Monika Thumová; Ludek Cervenka; Ivana Vanecková
Persistent antihypertensive effect of aliskiren is accompanied by reduced proteinuria and normalization of glomerular area in Ren-2 transgenic rats.
American journal of physiology. Renal physiology 2010;299(4):F758-66.
2010: Libor Kopkan; Arthur Hess; Zuzana Husková; Ludek Cervenka; L Gabriel Navar; Dewan S A Majid
High-salt intake enhances superoxide activity in eNOS knockout mice leading to the development of salt sensitivity.
American journal of physiology. Renal physiology 2010;299(3):F656-63.
2010: Zuzana Husková; Zdenka Vanourková; Michaela Erbanová; Monika Thumová; Martin Opocenský; John J Mullins; Herbert kramer; Marcela Bürgelová; Ludek Cervenka
Inappropriately high circulating and intrarenal angiotensin II levels during dietary salt loading exacerbate hypertension in Cyp1a1-Ren-2 transgenic rats.
Journal of hypertension 2010;28(3):495-509.
2009: Marcela Bürgelová; Zdenka Vanourková; Monika Thumová; Pavel Dvorák; Martin Opocenský; Herbert kramer; Michal Zelízko; Jan Malý; Michael Bader; Ludek Cervenka
Impairment of the angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas axis contributes to the acceleration of two-kidney, one-clip Goldblatt hypertension.
Journal of hypertension 2009;27(10):1988-2000.
2009: Libor Kopkan; Zuzana Husková; Zdenka Vanourková; Monika Thumová; Petra Skaroupková; Jan Malý; Herbert kramer; Petr Dvorák; Ludek Cervenka
Reduction of oxidative stress does not attenuate the development of angiotensin II-dependent hypertension in Ren-2 transgenic rats.
Vascular pharmacology 2009;51(2-3):175-81.
2009: Zdenka Vanourková; Herbert kramer; Michaela Erbanová; Angela Bäcker; Ludek Cervenka; Zuzana Husková; Vera Certíková Chábová; Vladimír Tesar; Petr Dvorák; Jan Malý; Ivana Vanecková
Endothelin receptor blockade does not affect blood pressure or angiotensin II levels in CYP1A1-Ren-2 transgenic rats with acutely induced hypertension.
Vascular pharmacology 2009;50(5-6):194-9.
2009: Michaela Erbanová; Monika Thumová; Zuzana Husková; Ivana Vanecková; Zdenka Vanourková; John J Mullins; Herbert kramer; Marcela Bürgelová; Dan Rakusan; Ludek Cervenka
Impairment of the autoregulation of renal hemodynamics and of the pressure-natriuresis relationship precedes the development of hypertension in Cyp1a1-Ren-2 transgenic rats.
Journal of hypertension 2009;27(3):575-86.
2009: Zdena Vernerová; P Kujal; Herbert kramer; Angela Bäcker; Ludek Cervenka; Ivana Vanecková
End-organ damage in hypertensive transgenic Ren-2 rats: influence of early and late endothelin receptor blockade.
Physiological research / Academia Scientiarum Bohemoslovaca 2009;58 Suppl 2():S69-78.
2008: Ludek Cervenka; Ivana Vanecková; Zuzana Husková; Zdenka Vanourková; Michaela Erbanová; Monika Thumová; Petra Skaroupková; Martin Opocenský; Jan Malý; Vera Certíková Chábová; Vladimír Tesar; Marcela Bürgelová; Ondrej Viklický; Vladimír Teplan; Michal Zelízko; Herbert kramer; L Gabriel Navar
Pivotal role of angiotensin II receptor subtype 1A in the development of two-kidney, one-clip hypertension: study in angiotensin II receptor subtype 1A knockout mice.
Journal of hypertension 2008;26(7):1379-89.
2008: Zdena Vernerová; Herbert kramer; Angela Bäcker; Ludek Cervenka; Martin Opocenský; Zuzana Husková; Zdenka Vanourková; Václav Eis; Vera Certíková Chábová; Vladimír Tesar; Jan Malý; Ivana Vanecková
Late-onset endothelin receptor blockade in hypertensive heterozygous REN-2 transgenic rats.
Vascular pharmacology 2008;48(4-6):165-73.
2007: Libor Kopkan; Zuzana Husková; Zdenka Vanourková; Monika Thumová; Petra Skaroupková; Ludek Cervenka; Dewan S A Majid
Superoxide and its interaction with nitric oxide modulates renal function in prehypertensive Ren-2 transgenic rats.
Journal of hypertension 2007;25(11):2257-65.
2007: Vera Certíková Chábová; Herbert kramer; Ivana Vanecková; Zdena Vernerová; Václav Eis; Vladimír Tesar; Petra Skaroupková; Monika Thumová; Stanislava Schejbalová; Zuzana Husková; Zdenka Vanourková; Alexander Kolský; John D Imig; Ludek Cervenka
Effects of chronic cytochrome P-450 inhibition on the course of hypertension and end-organ damage in Ren-2 transgenic rats.
Vascular pharmacology 2007;47(2-3):145-59.
2007: Ivana Vanecková; Libor Kopkan; Zuzana Husková; Zdenka Vanourková; Stanislava Schejbalová; Ludek Cervenka; Herbert kramer
AT1 receptor antisense therapy transiently lowers blood pressure in Ren-2 transgenic rats.
Vascular pharmacology 2007;47(1):63-7.
2007: Vera Certíková-Chábová; Herbert kramer; Ivana Vanecková; Monika Thumová; Petra Skaroupková; Vladimír Tesar; John R Falck; John D Imig; Ludek Cervenka
The roles of intrarenal 20-hydroxyeicosatetraenoic and epoxyeicosatrienoic acids in the regulation of renal function in hypertensive Ren-2 transgenic rats.
Kidney & blood pressure research 2007;30(5):335-46.
2007: Zuzana Husková; Herbert Kramer; Zdenka Vanourková; Monika Thumová; Jan Malý; Martin Opocenský; Petra Skaroupková; Alexander Kolský; Zdena Vernerová; Ludek Cervenka
Effects of dietary salt load and salt depletion on the course of hypertension and angiotensin II levels in male and female heterozygous Ren-2 transgenic rats.
Kidney & blood pressure research 2007;30(1):45-55.
2007: Ivana Vanecková; Libor Kopkan; Zuzana Husková; Zdenka Vanourková; Stanislava Schejbalová; Ludek Cervenka; Herbert kramer
Long-term prevention of hypertension and end-organ damage in Ren-2 transgenic rats is achieved only with persistent but not transient AT1 receptor blockade.
Kidney & blood pressure research 2007;30(1):38-44.
2006: Zdenka Vanourková; Herbert kramer; Zuzana Husková; Ivana Vanecková; Martin Opocenský; Vera Certíková Chábová; Vladimír Tesar; Petra Skaroupková; Monika Thumová; Michaela Dohnalová; John J Mullins; Ludek Cervenka
AT1 receptor blockade is superior to conventional triple therapy in protecting against end-organ damage in Cyp1a1-Ren-2 transgenic rats with inducible hypertension.
Journal of hypertension 2006;24(12):2465-72.
2006: Martin Opocenský; Herbert kramer; Angela Bäcker; Zdena Vernerová; Václav Eis; Ludek Cervenka; Vera Certíková-Chábová; Vladimír Tesar; Ivana Vanecková
Late-onset endothelin-A receptor blockade reduces podocyte injury in homozygous Ren-2 rats despite severe hypertension.
Hypertension 2006;48(5):965-71.
2006: Ivana Vanecková; Herbert kramer; Angela Bäcker; Stanislava Schejbalová; Zdena Vernerová; Václav Eis; Martin Opocenský; Petr Dvorák; Ludek Cervenka
Early-onset endothelin receptor blockade in hypertensive heterozygous Ren-2 rats.
Vascular pharmacology 2006;45(3):163-70.
2006: Zuzana Husková; Herbert kramer; Zdenka Vanourková; Ludek Cervenka
Effects of changes in sodium balance on plasma and kidney angiotensin II levels in anesthetized and conscious Ren-2 transgenic rats.
Journal of hypertension 2006;24(3):517-27.
2006: Zuzana Husková; Ivana Vanecková; Ludek Cervenka
[The renin-angiotensin system].
Ceskoslovenská fysiologie / Ústrední ústav biologický 2006;55(4):138-47.
2006: Zuzana Husková; Herbert kramer; Monika Thumová; Zdenka Vanourková; Marcela Bürgelová; Vladimír Teplan; Jan Malý; Ludek Cervenka
Effects of anesthesia on plasma and kidney ANG II levels in normotensive and ANG II-dependent hypertensive rats.
Kidney & blood pressure research 2006;29(2):74-83.
2005: Ivana Vanêcková; Herbert kramer; Angela Bäcker; Zdena Vernerová; Martin Opocensky; Ludek Cervenka
Early endothelin-A receptor blockade decreases blood pressure and ameliorates end-organ damage in homozygous Ren-2 rats.
Hypertension 2005;46(4):969-74.
2005: Libor Kopkan; Herbert kramer; Zuzana Husková; Zdenka Vanourková; Petra Skaroupková; Monika Thurmová; Ludek Cervenka
The role of intrarenal angiotensin II in the development of hypertension in Ren-2 transgenic rats.
Journal of hypertension 2005;23(8):1531-9.
2005: Marcela Bürgelová; Herbert kramer; Vladimír Teplan; Monika Thumová; Ludek Cervenka
Effects of angiotensin-(1-7) blockade on renal function in rats with enhanced intrarenal Ang II activity.
Kidney international 2005;67(4):1453-61.
2005: Ivana Vanecková; Herbert kramer; Jana Novotná; Ludmila Kazdová; Martin Opocenský; Michael Bader; Detlev Ganten; Ludek Cervenka
Roles of nitric oxide and oxidative stress in the regulation of blood pressure and renal function in prehypertensive Ren-2 transgenic rats.
Kidney & blood pressure research 2005;28(2):117-26.
2004: Libor Kopkan; Herbert kramer; Zuzana Husková; Zdenka Vanourková; Angela Bäcker; Michael Bader; Detlev Ganten; Ludek Cervenka
Plasma and kidney angiotensin II levels and renal functional responses to AT(1) receptor blockade in hypertensive Ren-2 transgenic rats.
Journal of hypertension 2004;22(4):819-25.
2004: Petr Dvorák; Herbert kramer; Angela Bäcker; Jan Malý; Libor Kopkan; Ivana Vanecková; Zdena Vernerová; Martin Opocenský; Vladimír Tesar; Michael Bader; Detlev Ganten; Jan Janda; Ludek Cervenka
Blockade of endothelin receptors attenuates end-organ damage in homozygous hypertensive ren-2 transgenic rats.
Kidney & blood pressure research 2004;27(4):248-58.
2004: Ivana Vanecková; Monika Cahová; Herbert kramer; Zuzana Husková; Petra Skaroupková; Radko Komers; Michael Bader; Detlev Ganten; Ludek Cervenka
Acute effects of cyclooxygenase-2 inhibition on renal function in heterozygous ren-2-transgenic rats on normal or low sodium intake.
Kidney & blood pressure research 2004;27(4):203-10.
2003: Ludek Cervenka; Ivana Vanecková; Jan Malý; Vladislav Horácek; Samir S El-Dahr
Genetic inactivation of the B2 receptor in mice worsens two-kidney, one-clip hypertension: role of NO and the AT2 receptor.
Journal of hypertension 2003;21(8):1531-8.
2002: Ludek Cervenka; Vladislav Horácek; Ivana Vanecková; Jaroslav A Hubácek; Michael I Oliverio; Thomas M Coffman; L Gabriel Navar
Essential role of AT1A receptor in the development of 2K1C hypertension.
Hypertension 2002;40(5):735-41.
2002: Ludek Cervenka; Herbert kramer; Jan Malý; Ivana Vanecková; Angela Bäcker; Dirk Bokemeyer; Michael Bader; Detlev Ganten; Kenneth D Mitchell
Role of nNOS in regulation of renal function in hypertensive Ren-2 transgenic rats.
Physiological research / Academia Scientiarum Bohemoslovaca 2002;51(6):571-80.
2002: Ivana Vanecková; Herbert kramer; Jan Malý; Angela Bäcker; Dirk Bokemeyer; Ludek Cervenka
Lack of a role of neuronal nitric oxide synthase in the regulation of the renal function in rats fed a low-sodium diet.
Kidney & blood pressure research 2002;25(4):224-31.
2002: Marcela Bürgelová; Herbert kramer; Vladimír Teplan; Gabriela Velicková; Stefan Vítko; Jirí Heller; Jan Malý; Ludek Cervenka
Intrarenal infusion of angiotensin-(1-7) modulates renal functional responses to exogenous angiotensin II in the rat.
Kidney & blood pressure research 2002;25(4):202-10.
2001: Ludek Cervenka; Herbert kramer; Jan Malý; Jirí Heller
Role of nNOS in regulation of renal function in angiotensin II-induced hypertension.
Hypertension 2001;38(2):280-5.
2001: Ludek Cervenka; J Maly; L Karasová; M Simová; Stefan Vítko; S Hellerová; Jirí Heller; Samir S El-Dahr
Angiotensin II-induced hypertension in bradykinin B2 receptor knockout mice.
Hypertension 2001;37(3):967-73.
2000: Ludek Cervenka; M Símová; Jan Malý; Jirí Heller
[Role of the kidney in long-term regulation of blood pressure and the development of hypertension].
Ceskoslovenská fysiologie / Ústrední ústav biologický 2000;49(3):116-33.
2000: Jirí Heller; Herbert kramer; Jan Malý; Ludek Cervenka; Vladislav Horácek
Effect of intrarenal infusion of angiotensin-(1-7) in the dog.
Kidney & blood pressure research 2000;23(2):89-94.
2000: L Gabriel Navar; Lisa M Harrison-Bernard; John D Imig; Ludek Cervenka; Kenneth D Mitchell
Renal responses to AT1 receptor blockade.
American journal of hypertension 2000;13(1 Pt 2):45S-54S.
1999: Ludek Cervenka; Kenneth D Mitchell; L Gabriel Navar
Renal function in mice: effects of volume expansion and angiotensin II.
Journal of the American Society of Nephrology : JASN 1999;10(12):2631-6.
1999: Ludek Cervenka; Kenneth D Mitchell; Michael I Oliverio; Thomas M Coffman; L Gabriel Navar
Renal function in the AT1A receptor knockout mouse during normal and volume-expanded conditions.
Kidney international 1999;56(5):1855-62.
1999: Ludek Cervenka; Lisa M Harrison-Bernard; Susana Dipp; G Primrose; John D Imig; Samir S El-Dahr
Early onset salt-sensitive hypertension in bradykinin B(2) receptor null mice.
Hypertension 1999;34(2):176-80.
1999: L Gabriel Navar; Lisa M Harrison-Bernard; John D Imig; Chi-Tarng Wang; Ludek Cervenka; Kenneth D Mitchell
Intrarenal angiotensin II generation and renal effects of AT1 receptor blockade.
Journal of the American Society of Nephrology : JASN 1999;10 Suppl 12():S266-72.
1999: Ludek Cervenka; Chi-Tarng Wang; Kenneth D Mitchell; L Gabriel Navar
Proximal tubular angiotensin II levels and renal functional responses to AT1 receptor blockade in nonclipped kidneys of Goldblatt hypertensive rats.
Hypertension 1999;33(1):102-7.
1999: Ludek Cervenka; L Gabriel Navar
Renal responses of the nonclipped kidney of two-kidney/one-clip Goldblatt hypertensive rats to type 1 angiotensin II receptor blockade with candesartan.
Journal of the American Society of Nephrology : JASN 1999;10 Suppl 11():S197-201.
1999: L Gabriel Navar; Lisa M Harrison-Bernard; Chi-Tarng Wang; Ludek Cervenka; Kenneth D Mitchell
Concentrations and actions of intraluminal angiotensin II.
Journal of the American Society of Nephrology : JASN 1999;10 Suppl 11():S189-95.
1998: Ludek Cervenka; Chi-Tarng Wang; L Gabriel Navar
Effects of acute AT1 receptor blockade by candesartan on arterial pressure and renal function in rats.
The American journal of physiology 1998;274(5 Pt 2):F940-5.
1995: Ludek Cervenka; J Heller
A comparison of the effect of feeding a low-protein diet and of pharmacological intervention on the course of ablation nephropathy in the rat.
Renal failure 1995;17(1):27-35.